The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||||||
UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
10X GENOMICS INC | CL A COM | 88025U109 | 7,238 | 254,134 | SH | DFND | 2 | 254,134 | 0 | 0 | |
ABBOTT LABS | COM | 002824100 | 151,899 | 1,569,851 | SH | DFND | 2 | 1,569,851 | 0 | 0 | |
ABBVIE INC | COM | 00287Y109 | 2,281 | 16,997 | SH | DFND | 2 | 16,997 | 0 | 0 | |
ABIOMED INC | COM | 003654100 | 40,867 | 166,355 | SH | DFND | 2 | 166,355 | 0 | 0 | |
ACADIA HEALTHCARE COMPANY IN | COM | 00404A109 | 71 | 906 | SH | DFND | 2 | 906 | 0 | 0 | |
ACCOLADE INC | COM | 00437E102 | 33,536 | 2,936,638 | SH | DFND | 3 | 2,936,638 | 0 | 0 | |
ACCOLADE INC | COM | 00437E102 | 7,254 | 635,232 | SH | DFND | 2 | 635,232 | 0 | 0 | |
ADAPTIVE BIOTECHNOLOGIES | COM | 00650F109 | 23,351 | 3,279,620 | SH | DFND | 3 | 3,279,620 | 0 | 0 | |
AGILENT TECHNOLOGIES INC | COM | 00846U101 | 1,049 | 8,627 | SH | DFND | 2 | 8,627 | 0 | 0 | |
AGIOS PHARMACEUTICALS INC | COM | 00847X104 | 113,991 | 4,030,792 | SH | DFND | 1,2 | 4,030,792 | 0 | 0 | |
AGIOS PHARMACEUTICALS INC | COM | 00847X104 | 792 | 28,000 | SH | DFND | 2 | 28,000 | 0 | 0 | |
AKERO THERAPEUTICS INC | COM | 00973Y108 | 1,418 | 41,634 | SH | DFND | 2 | 41,634 | 0 | 0 | |
ALIGN TECHNOLOGY INC | COM | 016255101 | 15,521 | 74,939 | SH | DFND | 2 | 74,939 | 0 | 0 | |
ALNYLAM PHARMACEUTICALS INC | COM | 02043Q107 | 184,147 | 920,000 | SH | DFND | 1,2 | 920,000 | 0 | 0 | |
ALNYLAM PHARMACEUTICALS INC | COM | 02043Q107 | 7,358 | 36,762 | SH | DFND | 2 | 36,762 | 0 | 0 | |
ALPHABET INC | CAP STK CL C | 02079K107 | 577 | 6,000 | SH | DFND | 2 | 6,000 | 0 | 0 | |
AMEDISYS INC | COM | 023436108 | 50,602 | 522,800 | SH | DFND | 3 | 522,800 | 0 | 0 | |
AMEDISYS INC | COM | 023436108 | 7,369 | 76,134 | SH | DFND | 2 | 76,134 | 0 | 0 | |
AMERICAN WELL CORP | CL A | 03044L105 | 6,353 | 1,769,703 | SH | DFND | 2 | 1,769,703 | 0 | 0 | |
AMERISOURCEBERGEN CORP | COM | 03073E105 | 1,612 | 11,910 | SH | DFND | 2 | 11,910 | 0 | 0 | |
AMGEN INC | COM | 031162100 | 10,187 | 45,196 | SH | DFND | 2 | 45,196 | 0 | 0 | |
APELLIS PHARMACEUTICALS INC | COM | 03753U106 | 66,384 | 971,944 | SH | DFND | 3 | 971,944 | 0 | 0 | |
APELLIS PHARMACEUTICALS INC | COM | 03753U106 | 2,425 | 35,500 | SH | DFND | 2 | 35,500 | 0 | 0 | |
ARCUS BIOSCIENCES INC | COM | 03969F109 | 2,184 | 83,500 | SH | DFND | 2 | 83,500 | 0 | 0 | |
ARGENX SE | SPONSORED ADR | 04016X101 | 322,168 | 892,503 | SH | DFND | 1,2 | 892,503 | 0 | 0 | |
ARGENX SE | SPONSORED ADR | 04016X101 | 9,690 | 26,843 | SH | DFND | 2 | 26,843 | 0 | 0 | |
ARVINAS INC | COM | 04335A105 | 95,049 | 2,136,412 | SH | DFND | 1,2 | 2,136,412 | 0 | 0 | |
ARVINAS INC | COM | 04335A105 | 2,418 | 54,350 | SH | DFND | 2 | 54,350 | 0 | 0 | |
ASTRAZENECA PLC | SPONSORED ADR | 046353108 | 2,457 | 44,400 | SH | DFND | 2 | 44,400 | 0 | 0 | |
ATRICURE INC | COM | 04963C209 | 25,120 | 642,447 | SH | DFND | 3 | 642,447 | 0 | 0 | |
AURINIA PHARMACEUTICALS INC | COM | 05156V102 | 21,405 | 2,846,457 | SH | DFND | 3 | 2,846,457 | 0 | 0 | |
AVALARA INC | COM | 05338G106 | 119 | 1,300 | SH | DFND | 2 | 1,300 | 0 | 0 | |
AVANTOR INC | COM | 05352A100 | 9,859 | 503,007 | SH | DFND | 2 | 503,007 | 0 | 0 | |
AXONICS INC | COM | 05465P101 | 81,956 | 1,163,490 | SH | DFND | 3 | 1,163,490 | 0 | 0 | |
AXONICS INC | COM | 05465P101 | 72,533 | 1,029,710 | SH | DFND | 2 | 1,029,710 | 0 | 0 | |
AXSOME THERAPEUTICS INC | COM | 05464T104 | 22,155 | 496,524 | SH | DFND | 3 | 496,524 | 0 | 0 | |
BAXTER INTL INC | COM | 071813109 | 17,211 | 319,548 | SH | DFND | 2 | 319,548 | 0 | 0 | |
BEAM THERAPEUTICS INC | COM | 07373V105 | 27,065 | 568,121 | SH | DFND | 1,2 | 568,121 | 0 | 0 | |
BEAM THERAPEUTICS INC | COM | 07373V105 | 172 | 3,600 | SH | DFND | 2 | 3,600 | 0 | 0 | |
BECTON DICKINSON & CO | COM | 075887109 | 74,612 | 334,838 | SH | DFND | 2 | 334,838 | 0 | 0 | |
BEIGENE LTD | SPONSORED ADR | 07725L102 | 940 | 7,000 | SH | DFND | 2 | 7,000 | 0 | 0 | |
BERKELEY LTS INC | COM | 084310101 | 1,101 | 385,014 | SH | DFND | 2 | 385,014 | 0 | 0 | |
BICYCLE THERAPEUTICS PLC | SPONSORED ADS | 088786108 | 2,282 | 98,100 | SH | DFND | 2 | 98,100 | 0 | 0 | |
BIOGEN INC | COM | 09062X103 | 7,672 | 28,735 | SH | DFND | 2 | 28,735 | 0 | 0 | |
BIOMARIN PHARMACEUTICAL INC | COM | 09061G101 | 4,535 | 53,493 | SH | DFND | 2 | 53,493 | 0 | 0 | |
BIONTECH SE | SPONSORED ADS | 09075V102 | 20,715 | 153,580 | SH | DFND | 2 | 153,580 | 0 | 0 | |
BIO RAD LABS INC | CL A | 090572207 | 42,472 | 101,818 | SH | DFND | 3 | 101,818 | 0 | 0 | |
BLACK DIAMOND THERAPEUTICS I | COM | 09203E105 | 7,933 | 4,694,113 | SH | DFND | 1,2 | 4,694,113 | 0 | 0 | |
BLACK DIAMOND THERAPEUTICS I | COM | 09203E105 | 39 | 23,000 | SH | DFND | 2 | 23,000 | 0 | 0 | |
BOSTON SCIENTIFIC CORP | COM | 101137107 | 147,331 | 3,804,047 | SH | DFND | 2 | 3,804,047 | 0 | 0 | |
BRISTOL-MYERS SQUIBB CO | COM | 110122108 | 502 | 7,062 | SH | DFND | 2 | 7,062 | 0 | 0 | |
CARDINAL HEALTH INC | COM | 14149Y108 | 61 | 918 | SH | DFND | 2 | 918 | 0 | 0 | |
CAREDX INC | COM | 14167L103 | 44,277 | 2,601,446 | SH | DFND | 3 | 2,601,446 | 0 | 0 | |
CARIBOU BIOSCIENCES INC | COM | 142038108 | 699 | 66,300 | SH | DFND | 2 | 66,300 | 0 | 0 | |
CASTLE BIOSCIENCES INC | COM | 14843C105 | 24,564 | 941,871 | SH | DFND | 3 | 941,871 | 0 | 0 | |
CATALENT INC | COM | 148806102 | 34 | 473 | SH | DFND | 2 | 473 | 0 | 0 | |
CELLDEX THERAPEUTICS INC | COM NEW | 15117B202 | 50,598 | 1,800,000 | SH | DFND | 1,2 | 1,800,000 | 0 | 0 | |
CENTENE CORP DEL | COM | 15135B101 | 41,118 | 528,440 | SH | DFND | 2 | 528,440 | 0 | 0 | |
CHARLES RIV LABS INC | COM | 159864107 | 51,757 | 262,993 | SH | DFND | 3 | 262,993 | 0 | 0 | |
CIGNA CORP NEW | COM | 125523100 | 52,359 | 188,701 | SH | DFND | 2 | 188,701 | 0 | 0 | |
COOPER COS INC | COM NEW | 216648402 | 21,459 | 81,313 | SH | DFND | 2 | 81,313 | 0 | 0 | |
CRISPR THERAPEUTICS AG | NAMEN AKT | H17182108 | 58,070 | 888,605 | SH | DFND | 1,2 | 888,605 | 0 | 0 | |
CRISPR THERAPEUTICS AG | NAMEN AKT | H17182108 | 2,594 | 39,700 | SH | DFND | 2 | 39,700 | 0 | 0 | |
CVS HEALTH CORP | COM | 126650100 | 21,469 | 225,114 | SH | DFND | 2 | 225,114 | 0 | 0 | |
CYTOKINETICS INC | COM NEW | 23282W605 | 3,450 | 71,200 | SH | DFND | 2 | 71,200 | 0 | 0 | |
DANAHER CORPORATION | COM | 235851102 | 94,905 | 367,435 | SH | DFND | 2 | 367,435 | 0 | 0 | |
DENALI THERAPEUTICS INC | COM | 24823R105 | 951 | 31,000 | SH | DFND | 2 | 31,000 | 0 | 0 | |
DESIGN THERAPEUTICS INC | COM | 25056L103 | 583 | 34,881 | SH | DFND | 2 | 34,881 | 0 | 0 | |
DEXCOM INC | COM | 252131107 | 69,301 | 860,460 | SH | DFND | 2 | 860,460 | 0 | 0 | |
DOLBY LABORATORIES INC | COM CL A | 25659T107 | 104 | 1,600 | SH | DFND | 2 | 1,600 | 0 | 0 | |
DOXIMITY INC | CL A | 26622P107 | 5,846 | 193,439 | SH | DFND | 2 | 193,439 | 0 | 0 | |
DR. REDDYS LABS LTD | ADR | 256135203 | 664 | 12,400 | SH | DFND | 2 | 12,400 | 0 | 0 | |
EDWARDS LIFESCIENCES CORP | COM | 28176E108 | 84,755 | 1,025,715 | SH | DFND | 2 | 1,025,715 | 0 | 0 | |
ELEVANCE HEALTH INC | COM | 036752103 | 45,647 | 100,492 | SH | DFND | 3 | 100,492 | 0 | 0 | |
ELEVANCE HEALTH INC | COM | 036752103 | 46,332 | 102,000 | SH | DFND | 2 | 102,000 | 0 | 0 | |
ELI LILLY & CO | COM | 532457108 | 3,069 | 9,490 | SH | DFND | 2 | 9,490 | 0 | 0 | |
ENVISTA HOLDINGS CORP | COM | 29415F104 | 27 | 822 | SH | DFND | 2 | 822 | 0 | 0 | |
EQUINIX INC | COM | 29444U700 | 23 | 40 | SH | DFND | 2 | 40 | 0 | 0 | |
ESPERION THERAPEUTICS INC | COM | 29664W105 | 28,100 | 4,194,064 | SH | DFND | 1,2 | 4,194,064 | 0 | 0 | |
ESPERION THERAPEUTICS INC | COM | 29664W105 | 209 | 31,200 | SH | DFND | 2 | 31,200 | 0 | 0 | |
ESSA PHARMA INC | COM NEW | 29668H708 | 10,701 | 5,879,583 | SH | DFND | 1,2 | 5,879,583 | 0 | 0 | |
ESSA PHARMA INC | COM NEW | 29668H708 | 35 | 19,000 | SH | DFND | 2 | 19,000 | 0 | 0 | |
ESTEE LAUDER COMPANIES | CL A | 518439104 | 291 | 1,348 | SH | DFND | 2 | 1,348 | 0 | 0 | |
EVERTEC INC | COM | 30040P103 | 23 | 739 | SH | DFND | 2 | 739 | 0 | 0 | |
EVOLENT HEALTH INC | CL A | 30050B101 | 38,618 | 1,074,816 | SH | DFND | 3 | 1,074,816 | 0 | 0 | |
EVOLENT HEALTH INC | CL A | 30050B101 | 28,537 | 794,239 | SH | DFND | 2 | 794,239 | 0 | 0 | |
EXACT SCIENCES CORP | COM | 30063P105 | 36,702 | 1,129,653 | SH | DFND | 3 | 1,129,653 | 0 | 0 | |
EXELIXIS INC | COM | 30161Q104 | 41,623 | 2,654,500 | SH | DFND | 1,2 | 2,654,500 | 0 | 0 | |
EXELIXIS INC | COM | 30161Q104 | 298 | 19,000 | SH | DFND | 2 | 19,000 | 0 | 0 | |
FATE THERAPEUTICS INC | COM | 31189P102 | 81,988 | 3,658,536 | SH | DFND | 1,2 | 3,658,536 | 0 | 0 | |
FATE THERAPEUTICS INC | COM | 31189P102 | 1,962 | 87,550 | SH | DFND | 2 | 87,550 | 0 | 0 | |
GENERATION BIO CO | COM | 37148K100 | 19,160 | 3,608,280 | SH | DFND | 1,2 | 3,608,280 | 0 | 0 | |
GENERATION BIO CO | COM | 37148K100 | 101 | 19,000 | SH | DFND | 2 | 19,000 | 0 | 0 | |
GILEAD SCIENCES INC | COM | 375558103 | 6,037 | 97,854 | SH | DFND | 2 | 97,854 | 0 | 0 | |
GLOBUS MEDICAL INC | CL A | 379577208 | 38,551 | 647,163 | SH | DFND | 2 | 647,163 | 0 | 0 | |
GRUPO AEROPORTUARIO DEL SURE | SPON ADR SER B | 40051E202 | 27 | 135 | SH | DFND | 2 | 135 | 0 | 0 | |
GUARDANT HEALTH INC | COM | 40131M109 | 3,342 | 62,083 | SH | DFND | 2 | 62,083 | 0 | 0 | |
HALOZYME THERAPEUTICS INC | COM | 40637H109 | 36,792 | 930,500 | SH | DFND | 2 | 930,500 | 0 | 0 | |
HARMONY BIOSCIENCES HOLDINGS | COM | 413197104 | 29,107 | 657,188 | SH | DFND | 2 | 657,188 | 0 | 0 | |
HCA HEALTHCARE INC | COM | 40412C101 | 52,525 | 285,789 | SH | DFND | 2 | 285,789 | 0 | 0 | |
HOLOGIC INC | COM | 436440101 | 16,221 | 251,412 | SH | DFND | 2 | 251,412 | 0 | 0 | |
HOMOLOGY MEDICINES INC | COM | 438083107 | 2,612 | 1,622,522 | SH | DFND | 1,2 | 1,622,522 | 0 | 0 | |
HORIZON THERAPEUTICS PUB L | SHS | G46188101 | 18,681 | 301,850 | SH | DFND | 2 | 301,850 | 0 | 0 | |
HUMANA INC | COM | 444859102 | 65,115 | 134,206 | SH | DFND | 2 | 134,206 | 0 | 0 | |
HUTCHMED CHINA LTD | SPONSORED ADS | 44842L103 | 15,947 | 1,758,075 | SH | DFND | 3 | 1,758,075 | 0 | 0 | |
IDEXX LABORATORIES INC | COM | 45168D104 | 35,454 | 108,822 | SH | DFND | 2 | 108,822 | 0 | 0 | |
ILLUMINA INC | COM | 452327109 | 16,394 | 85,927 | SH | DFND | 2 | 85,927 | 0 | 0 | |
INCYTE CORP | COM | 45337C102 | 179,333 | 2,691,077 | SH | DFND | 1,2 | 2,691,077 | 0 | 0 | |
INCYTE CORP | COM | 45337C102 | 3,545 | 53,200 | SH | DFND | 2 | 53,200 | 0 | 0 | |
INFOSYS LTD | SPONSORED ADR | 456788108 | 20 | 1,130 | SH | DFND | 2 | 1,130 | 0 | 0 | |
INHIBRX INC | COM | 45720L107 | 781 | 43,500 | SH | DFND | 2 | 43,500 | 0 | 0 | |
INSMED INC | COM PAR $.01 | 457669307 | 69,245 | 3,214,704 | SH | DFND | 3 | 3,214,704 | 0 | 0 | |
INSPIRE MEDICAL SYSTEMS INC | COM | 457730109 | 71,262 | 401,768 | SH | DFND | 2 | 401,768 | 0 | 0 | |
INSULET CORP | COM | 45784P101 | 85,785 | 373,953 | SH | DFND | 2 | 373,953 | 0 | 0 | |
INTELLIA THERAPEUTICS INC | COM | 45826J105 | 1,706 | 30,478 | SH | DFND | 2 | 30,478 | 0 | 0 | |
INTRA-CELLULAR THERAPIES INC | COM | 46116X101 | 153,153 | 3,291,479 | SH | DFND | 1,2 | 3,291,479 | 0 | 0 | |
INTRA-CELLULAR THERAPIES INC | COM | 46116X101 | 1,759 | 37,800 | SH | DFND | 2 | 37,800 | 0 | 0 | |
INTUITIVE SURGICAL INC | COM NEW | 46120E602 | 32,583 | 173,831 | SH | DFND | 3 | 173,831 | 0 | 0 | |
INTUITIVE SURGICAL INC | COM NEW | 46120E602 | 135,755 | 724,261 | SH | DFND | 2 | 724,261 | 0 | 0 | |
IONIS PHARMACEUTICALS INC | COM | 462222100 | 408,243 | 9,230,000 | SH | DFND | 1,2 | 9,230,000 | 0 | 0 | |
IONIS PHARMACEUTICALS INC | COM | 462222100 | 10,323 | 233,400 | SH | DFND | 2 | 233,400 | 0 | 0 | |
IPG PHOTONICS CORP | COM | 44980X109 | 89 | 1,050 | SH | DFND | 2 | 1,050 | 0 | 0 | |
IQVIA HOLDINGS INC | COM | 46266C105 | 29,024 | 160,227 | SH | DFND | 2 | 160,227 | 0 | 0 | |
ISHARES TR | MSCI CHINA ETF | 46429B671 | 174 | 4,100 | SH | DFND | 2 | 4,100 | 0 | 0 | |
JAZZ PHARMACEUTICALS PLC | SHS USD | G50871105 | 75,984 | 570,063 | SH | DFND | 3 | 570,063 | 0 | 0 | |
JAZZ PHARMACEUTICALS PLC | SHS USD | G50871105 | 33,826 | 253,776 | SH | DFND | 2 | 253,776 | 0 | 0 | |
JOHNSON & JOHNSON | COM | 478160104 | 5,010 | 30,671 | SH | DFND | 2 | 30,671 | 0 | 0 | |
JUMIA TECHNOLOGIES AG | SPONSORED ADS | 48138M105 | 105 | 18,000 | SH | DFND | 2 | 18,000 | 0 | 0 | |
KEZAR LIFE SCIENCES INC | COM | 49372L100 | 25,830 | 3,000,000 | SH | DFND | 1,2 | 3,000,000 | 0 | 0 | |
KEZAR LIFE SCIENCES INC | COM | 49372L100 | 267 | 31,000 | SH | DFND | 2 | 31,000 | 0 | 0 | |
KOSMOS ENERGY LTD | COM | 500688106 | 1,646 | 318,300 | SH | DFND | 2 | 318,300 | 0 | 0 | |
KRYSTAL BIOTECH INC | COM | 501147102 | 1,276 | 18,300 | SH | DFND | 2 | 18,300 | 0 | 0 | |
LABORATORY CRP OF AMER HLDGS | COM NEW | 50540R409 | 799 | 3,900 | SH | DFND | 2 | 3,900 | 0 | 0 | |
LEGEND BIOTECH CORP | SPONSORED ADS | 52490G102 | 25,519 | 625,461 | SH | DFND | 2 | 625,461 | 0 | 0 | |
MACROGENICS INC | COM | 556099109 | 25,173 | 7,275,564 | SH | DFND | 1,2 | 7,275,564 | 0 | 0 | |
MACROGENICS INC | COM | 556099109 | 173 | 49,950 | SH | DFND | 2 | 49,950 | 0 | 0 | |
MARKETAXESS HOLDINGS INC | COM | 57060D108 | 147 | 662 | SH | DFND | 2 | 662 | 0 | 0 | |
MCKESSON CORP | COM | 58155Q103 | 999 | 2,938 | SH | DFND | 2 | 2,938 | 0 | 0 | |
MEDTRONIC PLC | SHS | G5960L103 | 49,736 | 615,926 | SH | DFND | 2 | 615,926 | 0 | 0 | |
MERCADOLIBRE INC | COM | 58733R102 | 141 | 170 | SH | DFND | 2 | 170 | 0 | 0 | |
MERCK & CO. INC. | COM | 58933Y105 | 417 | 4,844 | SH | DFND | 2 | 4,844 | 0 | 0 | |
MERSANA THERAPEUTICS INC | COM | 59045L106 | 26,136 | 3,866,200 | SH | DFND | 1,2 | 3,866,200 | 0 | 0 | |
MERSANA THERAPEUTICS INC | COM | 59045L106 | 1,463 | 216,400 | SH | DFND | 2 | 216,400 | 0 | 0 | |
MERUS NV | COM | N5749R100 | 509 | 25,400 | SH | DFND | 2 | 25,400 | 0 | 0 | |
MODERNA INC | COM | 60770K107 | 177,606 | 1,501,951 | SH | DFND | 1,2 | 1,501,951 | 0 | 0 | |
MODERNA INC | COM | 60770K107 | 6,841 | 57,850 | SH | DFND | 2 | 57,850 | 0 | 0 | |
MOLECULAR TEMPLATES INC | COM | 608550109 | 8,391 | 11,192,003 | SH | DFND | 1,2 | 11,192,003 | 0 | 0 | |
MOLECULAR TEMPLATES INC | COM | 608550109 | 64 | 86,000 | SH | DFND | 2 | 86,000 | 0 | 0 | |
MOLINA HEALTHCARE INC | COM | 60855R100 | 79,356 | 240,590 | SH | DFND | 2 | 240,590 | 0 | 0 | |
MYOVANT SCIENCES LTD | COM | G637AM102 | 105,473 | 5,872,639 | SH | DFND | 1,2 | 5,872,639 | 0 | 0 | |
MYOVANT SCIENCES LTD | COM | G637AM102 | 718 | 40,000 | SH | DFND | 2 | 40,000 | 0 | 0 | |
NEKTAR THERAPEUTICS | COM | 640268108 | 47 | 14,800 | SH | DFND | 2 | 14,800 | 0 | 0 | |
NEUROCRINE BIOSCIENCES INC | COM | 64125C109 | 297,222 | 2,798,437 | SH | DFND | 1,2 | 2,798,437 | 0 | 0 | |
NEUROCRINE BIOSCIENCES INC | COM | 64125C109 | 6,023 | 56,709 | SH | DFND | 2 | 56,709 | 0 | 0 | |
NEUROPACE INC | COM | 641288105 | 1,456 | 388,368 | SH | DFND | 2 | 388,368 | 0 | 0 | |
NEVRO CORP | COM | 64157F103 | 12,155 | 260,835 | SH | DFND | 2 | 260,835 | 0 | 0 | |
OLINK HOLDING AB | SPONSORED ADS | 680710100 | 2,799 | 230,522 | SH | DFND | 2 | 230,522 | 0 | 0 | |
OMNICELL INC | COM | 68213N109 | 36,055 | 414,284 | SH | DFND | 2 | 414,284 | 0 | 0 | |
OPTHEA LTD | SPONSORED ADS | 68386J208 | 283 | 47,000 | SH | DFND | 2 | 47,000 | 0 | 0 | |
OPTION CARE HEALTH INC | COM NEW | 68404L201 | 82,740 | 2,629,172 | SH | DFND | 3 | 2,629,172 | 0 | 0 | |
OUTSET MEDICAL INC | COM | 690145107 | 27,200 | 1,707,475 | SH | DFND | 3 | 1,707,475 | 0 | 0 | |
OUTSET MEDICAL INC | COM | 690145107 | 11,310 | 709,981 | SH | DFND | 2 | 709,981 | 0 | 0 | |
PACIFIC BIOSCIENCES OF CALIF | COM | 69404D108 | 17,360 | 2,990,461 | SH | DFND | 3 | 2,990,461 | 0 | 0 | |
PACIFIC BIOSCIENCES OF CALIF | COM | 69404D108 | 14,217 | 2,449,090 | SH | DFND | 2 | 2,449,090 | 0 | 0 | |
PENUMBRA INC | COM | 70975L107 | 35,981 | 189,774 | SH | DFND | 2 | 189,774 | 0 | 0 | |
PFIZER INC | COM | 717081103 | 33,577 | 767,300 | SH | DFND | 2 | 767,300 | 0 | 0 | |
PHREESIA INC | COM | 71944F106 | 16,980 | 666,419 | SH | DFND | 2 | 666,419 | 0 | 0 | |
PRIVIA HEALTH GROUP INC | COM | 74276R102 | 17,542 | 515,030 | SH | DFND | 2 | 515,030 | 0 | 0 | |
PROCEPT BIOROBOTICS CORP | COM | 74276L105 | 24,431 | 589,262 | SH | DFND | 2 | 589,262 | 0 | 0 | |
PULMONX CORP | COM | 745848101 | 2,888 | 173,336 | SH | DFND | 2 | 173,336 | 0 | 0 | |
REGENERON PHARMACEUTICALS | COM | 75886F107 | 11,979 | 17,389 | SH | DFND | 2 | 17,389 | 0 | 0 | |
RELAY THERAPEUTICS INC | COM | 75943R102 | 92,181 | 4,120,720 | SH | DFND | 1,2 | 4,120,720 | 0 | 0 | |
RELAY THERAPEUTICS INC | COM | 75943R102 | 1,881 | 84,100 | SH | DFND | 2 | 84,100 | 0 | 0 | |
RELMADA THERAPEUTICS INC | COM | 75955J402 | 1,969 | 53,187 | SH | DFND | 2 | 53,187 | 0 | 0 | |
REPLIGEN CORP | COM | 759916109 | 1,235 | 6,600 | SH | DFND | 2 | 6,600 | 0 | 0 | |
RESMED INC | COM | 761152107 | 18,471 | 84,612 | SH | DFND | 2 | 84,612 | 0 | 0 | |
REVOLUTION MEDICINES INC | COM | 76155X100 | 90,763 | 4,602,562 | SH | DFND | 1,2 | 4,602,562 | 0 | 0 | |
REVOLUTION MEDICINES INC | COM | 76155X100 | 1,530 | 77,600 | SH | DFND | 2 | 77,600 | 0 | 0 | |
SAGE THERAPEUTICS INC | COM | 78667J108 | 115,533 | 2,950,278 | SH | DFND | 1,2 | 2,950,278 | 0 | 0 | |
SAGE THERAPEUTICS INC | COM | 78667J108 | 799 | 20,400 | SH | DFND | 2 | 20,400 | 0 | 0 | |
SAREPTA THERAPEUTICS INC | COM | 803607100 | 80,860 | 731,504 | SH | DFND | 3 | 731,504 | 0 | 0 | |
SAREPTA THERAPEUTICS INC | COM | 803607100 | 2,697 | 24,394 | SH | DFND | 2 | 24,394 | 0 | 0 | |
SCHOLAR ROCK HOLDING CORP | COM | 80706P103 | 14,780 | 2,132,725 | SH | DFND | 1,2 | 2,132,725 | 0 | 0 | |
SCHOLAR ROCK HOLDING CORP | COM | 80706P103 | 134 | 19,300 | SH | DFND | 2 | 19,300 | 0 | 0 | |
SEAGEN INC | COM | 81181C104 | 5,874 | 42,926 | SH | DFND | 2 | 42,926 | 0 | 0 | |
SEER INC | COM CL A | 81578P106 | 1,054 | 136,133 | SH | DFND | 2 | 136,133 | 0 | 0 | |
SHOCKWAVE MEDICAL INC | COM | 82489T104 | 76,784 | 276,132 | SH | DFND | 2 | 276,132 | 0 | 0 | |
SIGHT SCIENCES INC | COM | 82657M105 | 1,871 | 294,606 | SH | DFND | 2 | 294,606 | 0 | 0 | |
SILK ROAD MEDICAL INC | COM | 82710M100 | 47,131 | 1,047,356 | SH | DFND | 3 | 1,047,356 | 0 | 0 | |
SKYWORKS SOLUTIONS INC | COM | 83088M102 | 179 | 2,100 | SH | DFND | 2 | 2,100 | 0 | 0 | |
SPDR S&P 500 ETF TRUST | TR UNIT | 78462F103 | 643 | 1,800 | SH | DFND | 2 | 1,800 | 0 | 0 | |
SPDR S&P SER TR | S&P OILGAS EXP | 78468R556 | 486 | 3,900 | SH | DFND | 2 | 3,900 | 0 | 0 | |
STRYKER CORPORATION | COM | 863667101 | 96,598 | 476,932 | SH | DFND | 2 | 476,932 | 0 | 0 | |
SUPERNUS PHARMACEUTICALS INC | COM | 868459108 | 4,038 | 119,278 | SH | DFND | 2 | 119,278 | 0 | 0 | |
TAIWAN SEMICONDUCTOR MFG LTD | SPONSORED ADS | 874039100 | 53 | 770 | SH | DFND | 2 | 770 | 0 | 0 | |
TANDEM DIABETES CARE INC | COM NEW | 875372203 | 49,785 | 1,040,448 | SH | DFND | 3 | 1,040,448 | 0 | 0 | |
TANDEM DIABETES CARE INC | COM NEW | 875372203 | 25,148 | 525,567 | SH | DFND | 2 | 525,567 | 0 | 0 | |
TELADOC HEALTH INC | COM | 87918A105 | 9,894 | 390,286 | SH | DFND | 2 | 390,286 | 0 | 0 | |
TELEFLEX INC | COM | 879369106 | 6,342 | 31,480 | SH | DFND | 2 | 31,480 | 0 | 0 | |
THERMO FISHER SCIENTIFIC INC | COM | 883556102 | 36,591 | 72,144 | SH | DFND | 2 | 72,144 | 0 | 0 | |
TRANSMEDICS GROUP INC | COM | 89377M109 | 27,290 | 653,814 | SH | DFND | 2 | 653,814 | 0 | 0 | |
UNITED MICROELECTRONICS CORP | SPON ADR NEW | 910873405 | 15 | 2,698 | SH | DFND | 2 | 2,698 | 0 | 0 | |
UNITED THERAPEUTICS CORP | COM | 91307C102 | 63 | 301 | SH | DFND | 2 | 301 | 0 | 0 | |
UNITEDHEALTH GROUP INC | COM | 91324P102 | 66,442 | 131,557 | SH | DFND | 3 | 131,557 | 0 | 0 | |
UNITEDHEALTH GROUP INC | COM | 91324P102 | 83,431 | 165,197 | SH | DFND | 2 | 165,197 | 0 | 0 | |
VANECK ETF TRUST | GOLD MINERS ETF | 92189F106 | 323 | 13,400 | SH | DFND | 2 | 13,400 | 0 | 0 | |
VANECK ETF TRUST | JUNIOR GOLD MINE | 92189F791 | 147 | 5,000 | SH | DFND | 2 | 5,000 | 0 | 0 | |
VEEVA SYSTEMS INC | CL A COM | 922475108 | 25,984 | 157,591 | SH | DFND | 2 | 157,591 | 0 | 0 | |
VERTEX PHARMACEUTICALS INC | COM | 92532F100 | 275,214 | 950,523 | SH | DFND | 1,2 | 950,523 | 0 | 0 | |
VERTEX PHARMACEUTICALS INC | COM | 92532F100 | 35,020 | 120,952 | SH | DFND | 3 | 120,952 | 0 | 0 | |
VERTEX PHARMACEUTICALS INC | COM | 92532F100 | 25,089 | 86,651 | SH | DFND | 2 | 86,651 | 0 | 0 | |
VIRIDIAN THERAPEUTICS INC | COM | 92790C104 | 946 | 46,100 | SH | DFND | 2 | 46,100 | 0 | 0 | |
WAVE LIFE SCIENCES LTD | SHS | Y95308105 | 16,225 | 4,494,458 | SH | DFND | 1,2 | 4,494,458 | 0 | 0 | |
XENCOR INC | COM | 98401F105 | 660 | 25,400 | SH | DFND | 2 | 25,400 | 0 | 0 | |
ZAI LAB LTD | ADR | 98887Q104 | 1,278 | 36,600 | SH | DFND | 2 | 36,600 | 0 | 0 | |
ZIMMER BIOMET HOLDINGS INC | COM | 98956P102 | 27,734 | 265,270 | SH | DFND | 2 | 265,270 | 0 | 0 | |
ZOETIS INC | CL A | 98978V103 | 36 | 246 | SH | DFND | 2 | 246 | 0 | 0 |