Bellevue (BLVGF) 13F-HR Quarterly holdings report by institutional manager

The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

OMB APPROVAL

OMB Number:		3235-0006
Expires:	Oct 31, 2018
Estimated average burden
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COLUMN 1	COLUMN 2	COLUMN 3	COLUMN 4	COLUMN 5			COLUMN 6	COLUMN 7	COLUMN 8
			VALUE	SHRS OR	SH/	PUT/	INVESTMENT	OTHER	VOTING AUTHORITY
NAME OF ISSUER	TITLE OF CLASS	CUSIP	(x$1000)	PRN AMT	PRN	CALL	DISCRETION	MANAGER	SOLE	SHARED	NONE
10X GENOMICS INC	CL A COM	88025U109	11,833,744	324,746	SH		DFND	2	324,746	0	0
ABBOTT LABS	COM	002824100	184,938,949	1,684,479	SH		DFND	2	1,684,479	0	0
ABBVIE INC	COM	00287Y109	2,618,082	16,200	SH		DFND	2	16,200	0	0
ACADIA HEALTHCARE CO IN	COM	00404A109	105,946	1,287	SH		DFND	2	1,287	0	0
ACCOLADE INC	COM	00437E102	4,948,457	635,232	SH		DFND	2	635,232	0	0
ACCOLADE INC	COM	00437E102	23,697,531	3,042,045	SH		DFND	3	3,042,045	0	0
ADAPTIVE BIOTECHNOLOGIES COR	COM	00650F109	22,615,401	2,960,131	SH		DFND	3	2,960,131	0	0
AGILENT TECHNOLOGIES INC	COM	00846U101	1,193,908	7,978	SH		DFND	2	7,978	0	0
AGIOS PHARMACEUTICALS INC	COM	00847X104	730,080	26,000	SH		DFND	2	26,000	0	0
AGIOS PHARMACEUTICALS INC	COM	00847X104	113,184,639	4,030,792	SH		DFND	1,2	4,030,792	0	0
AKERO THERAPEUTICS INC	COM	00973Y108	2,337,220	42,650	SH		DFND	2	42,650	0	0
ALIGN TECHNOLOGY INC	COM	016255101	16,702,015	79,194	SH		DFND	2	79,194	0	0
ALKERMES PLC	SHS	G01767105	1,580,865	35,500	SH		DFND	2	35,500	0	0
ALNYLAM PHARMACEUTICALS INC	COM	02043Q107	7,417,769	31,213	SH		DFND	2	31,213	0	0
ALNYLAM PHARMACEUTICALS INC	COM	02043Q107	211,508,500	890,000	SH		DFND	1,2	890,000	0	0
ALPHABET INC	CAP STK CL C	02079K107	532,380	6,000	SH		DFND	2	6,000	0	0
AMEDISYS INC	COM	023436108	6,360,234	76,134	SH		DFND	2	76,134	0	0
AMEDISYS INC	COM	023436108	44,892,558	537,378	SH		DFND	3	537,378	0	0
AMERICAN WELL CORP	CL A	03044L105	5,525,334	1,952,415	SH		DFND	2	1,952,415	0	0
AMERISOURCEBERGEN CORP	COM	03073E105	1,691,899	10,210	SH		DFND	2	10,210	0	0
AMGEN INC	COM	031162100	10,226,939	38,939	SH		DFND	2	38,939	0	0
APELLIS PHARMACEUTICALS INC	COM	03753U106	1,835,705	35,500	SH		DFND	2	35,500	0	0
APELLIS PHARMACEUTICALS INC	COM	03753U106	55,263,356	1,068,717	SH		DFND	3	1,068,717	0	0
ARCUS BIOSCIENCES INC	COM	03969F109	1,362,068	65,864	SH		DFND	2	65,864	0	0
ARGENX SE	SPONSORED ADR	04016X101	7,045,102	18,597	SH		DFND	2	18,597	0	0
ARGENX SE	SPONSORED ADR	04016X101	338,106,911	892,503	SH		DFND	1,2	892,503	0	0
ARROWHEAD PHARMACEUTICALS IN	COM	04280A100	863,928	21,300	SH		DFND	2	21,300	0	0
ARVINAS INC	COM	04335A105	478,940	14,000	SH		DFND	2	14,000	0	0
ARVINAS INC	COM	04335A105	73,086,655	2,136,412	SH		DFND	1,2	2,136,412	0	0
ASTRAZENECA PLC	SPONSORED ADR	046353108	4,648,252	68,500	SH		DFND	2	68,500	0	0
ATRICURE INC	COM	04963C209	28,585,557	644,109	SH		DFND	3	644,109	0	0
AURINIA PHARMACEUTICALS INC	COM	05156V102	5,574,001	1,290,278	SH		DFND	3	1,290,278	0	0
AVANTOR INC	COM	05352A100	9,946,487	471,621	SH		DFND	2	471,621	0	0
AXONICS INC	COM	05465P101	49,286,271	788,202	SH		DFND	2	788,202	0	0
AXONICS INC	COM	05465P101	69,924,735	1,118,259	SH		DFND	3	1,118,259	0	0
AXSOME THERAPEUTICS INC	COM	05464T104	58,850	763	SH		DFND	2	763	0	0
AXSOME THERAPEUTICS INC	COM	05464T104	33,620,581	435,895	SH		DFND	3	435,895	0	0
BAXTER INTL INC	COM	071813109	16,345,111	320,681	SH		DFND	2	320,681	0	0
BEAM THERAPEUTICS INC	COM	07373V105	140,796	3,600	SH		DFND	2	3,600	0	0
BEAM THERAPEUTICS INC	COM	07373V105	27,107,962	693,121	SH		DFND	1,2	693,121	0	0
BECTON DICKINSON & CO	COM	075887109	84,315,708	331,560	SH		DFND	2	331,560	0	0
BEIGENE LTD	SPONSORED ADR	07725L102	7,714,819	34,500	SH		DFND	2	34,500	0	0
BELLUS HEALTH INC	COM NEW	07987C204	369,119	44,905	SH		DFND	2	44,905	0	0
BERKELEY LTS INC	COM	084310101	1,031,838	385,014	SH		DFND	2	385,014	0	0
BICYCLE THERAPEUTICS PLC	SPONSORED ADS	088786108	2,077,920	70,200	SH		DFND	2	70,200	0	0
BIOGEN INC	COM	09062X103	7,865,636	28,404	SH		DFND	2	28,404	0	0
BIOMARIN PHARMACEUTICAL INC	COM	09061G101	6,280,291	60,685	SH		DFND	2	60,685	0	0
BIONTECH SE	SPONSORED ADS	09075V102	33,210,638	221,080	SH		DFND	2	221,080	0	0
BIO RAD LABS INC	CL A	090572207	46,740,827	111,158	SH		DFND	3	111,158	0	0
BLACK DIAMOND THERAPEUTICS I	COM	09203E105	41,400	23,000	SH		DFND	2	23,000	0	0
BLACK DIAMOND THERAPEUTICS I	COM	09203E105	9,680,110	5,377,839	SH		DFND	1,2	5,377,839	0	0
BOSTON SCIENTIFIC CORP	COM	101137107	180,588,293	3,902,924	SH		DFND	2	3,902,924	0	0
BRISTOL-MYERS SQUIBB CO	COM	110122108	3,615,847	50,255	SH		DFND	2	50,255	0	0
CARDINAL HEALTH INC	COM	14149Y108	814,822	10,600	SH		DFND	2	10,600	0	0
CAREDX INC	COM	14167L103	36,151,992	3,168,448	SH		DFND	3	3,168,448	0	0
CASTLE BIOSCIENCES INC	COM	14843C105	22,229,104	944,312	SH		DFND	3	944,312	0	0
CELLDEX THERAPEUTICS INC	COM NEW	15117B202	80,226,000	1,800,000	SH		DFND	1,2	1,800,000	0	0
CENTENE CORP DEL	COM	15135B101	56,878,692	693,558	SH		DFND	2	693,558	0	0
CHARLES RIV LABS INTL INC	COM	159864107	63,185,988	289,977	SH		DFND	3	289,977	0	0
CIGNA CORP NEW	COM	125523100	52,557,482	158,621	SH		DFND	2	158,621	0	0
COOPER COS INC	COM NEW	216648402	26,887,770	81,313	SH		DFND	2	81,313	0	0
CRISPR THERAPEUTICS AG	NAMEN AKT	H17182108	939,015	23,100	SH		DFND	2	23,100	0	0
CRISPR THERAPEUTICS AG	NAMEN AKT	H17182108	36,121,793	888,605	SH		DFND	1,2	888,605	0	0
CVS HEALTH CORP	COM	126650100	19,029,864	204,205	SH		DFND	2	204,205	0	0
CYTOKINETICS INC	COM NEW	23282W605	2,483,444	54,200	SH		DFND	2	54,200	0	0
DANAHER CORPORATION	COM	235851102	97,236,617	366,350	SH		DFND	2	366,350	0	0
DENALI THERAPEUTICS INC	COM	24823R105	862,110	31,000	SH		DFND	2	31,000	0	0
DESIGN THERAPEUTICS INC	COM	25056L103	357,879	34,881	SH		DFND	2	34,881	0	0
DEXCOM INC	COM	252131107	111,935,022	988,476	SH		DFND	2	988,476	0	0
DOLBY LABORATORIES INC	COM CL A	25659T107	112,864	1,600	SH		DFND	2	1,600	0	0
DOXIMITY INC	CL A	26622P107	15,054,311	448,579	SH		DFND	2	448,579	0	0
DR REDDYS LABS LTD	ADR	256135203	6,430,506	125,500	SH		DFND	2	125,500	0	0
EDWARDS LIFESCIENCES CORP	COM	28176E108	79,394,814	1,064,131	SH		DFND	2	1,064,131	0	0
ELEVANCE HEALTH INC	COM	036752103	41,733,187	81,356	SH		DFND	2	81,356	0	0
ELEVANCE HEALTH INC	COM	036752103	34,915,303	68,065	SH		DFND	3	68,065	0	0
LILLY ELI & CO	COM	532457108	4,044,361	11,055	SH		DFND	2	11,055	0	0
EQUINIX INC	COM	29444U700	26,201	40	SH		DFND	2	40	0	0
ESPERION THERAPEUTICS INC NE	COM	29664W105	848,526	136,200	SH		DFND	2	136,200	0	0
ESPERION THERAPEUTICS INC NE	COM	29664W105	26,129,019	4,194,064	SH		DFND	1,2	4,194,064	0	0
ESSA PHARMA INC	COM NEW	29668H708	47,880	19,000	SH		DFND	2	19,000	0	0
ESSA PHARMA INC	COM NEW	29668H708	19,856,549	7,879,583	SH		DFND	1,2	7,879,583	0	0
EVERTEC INC	COM	30040P103	23,929	739	SH		DFND	2	739	0	0
EVOLENT HEALTH INC	CL A	30050B101	12,413,410	442,073	SH		DFND	2	442,073	0	0
EVOLENT HEALTH INC	CL A	30050B101	43,287,566	1,541,580	SH		DFND	3	1,541,580	0	0
EXACT SCIENCES CORP	COM	30063P105	8,805,502	177,853	SH		DFND	2	177,853	0	0
EXACT SCIENCES CORP	COM	30063P105	56,152,361	1,134,162	SH		DFND	3	1,134,162	0	0
EXELIXIS INC	COM	30161Q104	304,760	19,000	SH		DFND	2	19,000	0	0
EXELIXIS INC	COM	30161Q104	42,578,180	2,654,500	SH		DFND	1,2	2,654,500	0	0
FATE THERAPEUTICS INC	COM	31189P102	216,935	21,500	SH		DFND	2	21,500	0	0
FATE THERAPEUTICS INC	COM	31189P102	48,833,370	4,839,779	SH		DFND	1,2	4,839,779	0	0
GENERATION BIO CO	COM	37148K100	74,670	19,000	SH		DFND	2	19,000	0	0
GENERATION BIO CO	COM	37148K100	14,180,540	3,608,280	SH		DFND	1,2	3,608,280	0	0
GILEAD SCIENCES INC	COM	375558103	11,189,947	130,343	SH		DFND	2	130,343	0	0
GLOBUS MED INC	CL A	379577208	50,516,969	680,180	SH		DFND	2	680,180	0	0
GRUPO AEROPORTUARIO DEL SURE	SPON ADR SER B	40051E202	157	135	SH		DFND	2	135	0	0
GUARDANT HEALTH INC	COM	40131M109	3,684,376	135,455	SH		DFND	2	135,455	0	0
HALOZYME THERAPEUTICS INC	COM	40637H109	46,242,630	812,700	SH		DFND	2	812,700	0	0
HARMONY BIOSCIENCES HLDGS IN	COM	413197104	32,850,179	596,192	SH		DFND	2	596,192	0	0
HCA HEALTHCARE INC	COM	40412C101	79,500,188	331,306	SH		DFND	2	331,306	0	0
HOLOGIC INC	COM	436440101	18,191,623	243,171	SH		DFND	2	243,171	0	0
HOMOLOGY MEDICINES INC	COM	438083107	2,044,378	1,622,522	SH		DFND	1,2	1,622,522	0	0
HORIZON THERAPEUTICS PUB L	SHS	G46188101	1,412,372	12,411	SH		DFND	2	12,411	0	0
HUMANA INC	COM	444859102	56,616,970	110,539	SH		DFND	2	110,539	0	0
HUTCHMED CHINA LTD	SPONSORED ADS	44842L103	284,255	17,800	SH		DFND	2	17,800	0	0
HUTCHMED CHINA LTD	SPONSORED ADS	44842L103	28,143,506	1,762,344	SH		DFND	3	1,762,344	0	0
IDEXX LABS INC	COM	45168D104	44,395,023	108,822	SH		DFND	2	108,822	0	0
ILLUMINA INC	COM	452327109	19,190,195	94,907	SH		DFND	2	94,907	0	0
INCYTE CORP	COM	45337C102	5,293,088	65,900	SH		DFND	2	65,900	0	0
INCYTE CORP	COM	45337C102	232,211,305	2,891,077	SH		DFND	1,2	2,891,077	0	0
INFOSYS LTD	SPONSORED ADR	456788108	20,607	1,130	SH		DFND	2	1,130	0	0
INHIBRX INC	COM	45720L107	731,808	29,700	SH		DFND	2	29,700	0	0
INSMED INC	COM PAR $.01	457669307	65,478,596	3,277,207	SH		DFND	3	3,277,207	0	0
INSPIRE MED SYS INC	COM	457730109	101,190,775	401,742	SH		DFND	2	401,742	0	0
INSULET CORP	COM	45784P101	101,794,174	345,780	SH		DFND	2	345,780	0	0
INTRA-CELLULAR THERAPIES INC	COM	46116X101	2,686,060	50,757	SH		DFND	2	50,757	0	0
INTRA-CELLULAR THERAPIES INC	COM	46116X101	174,185,069	3,291,479	SH		DFND	1,2	3,291,479	0	0
INTUITIVE SURGICAL INC	COM NEW	46120E602	224,526,168	846,151	SH		DFND	2	846,151	0	0
INTUITIVE SURGICAL INC	COM NEW	46120E602	29,436,602	110,935	SH		DFND	3	110,935	0	0
IONIS PHARMACEUTICALS INC	COM	462222100	4,113,153	108,900	SH		DFND	2	108,900	0	0
IONIS PHARMACEUTICALS INC	COM	462222100	363,913,950	9,635,000	SH		DFND	1,2	9,635,000	0	0
IPG PHOTONICS CORP	COM	44980X109	99,404	1,050	SH		DFND	2	1,050	0	0
IQVIA HLDGS INC	COM	46266C105	37,560,435	183,320	SH		DFND	2	183,320	0	0
ISHARES TR	MSCI CHINA ETF	46429B671	194,750	4,100	SH		DFND	2	4,100	0	0
IVERIC BIO INC	COM	46583P102	894,938	41,800	SH		DFND	2	41,800	0	0
JAZZ PHARMACEUTICALS PLC	SHS USD	G50871105	43,648,072	273,982	SH		DFND	2	273,982	0	0
JAZZ PHARMACEUTICALS PLC	SHS USD	G50871105	76,891,609	482,654	SH		DFND	3	482,654	0	0
JOHNSON & JOHNSON	COM	478160104	4,597,670	26,027	SH		DFND	2	26,027	0	0
JUMIA TECHNOLOGIES AG	SPONSORED ADS	48138M105	57,780	18,000	SH		DFND	2	18,000	0	0
KARUNA THERAPEUTICS INC	COM	48576A100	1,434,450	7,300	SH		DFND	2	7,300	0	0
KEZAR LIFE SCIENCES INC	COM	49372L100	218,240	31,000	SH		DFND	2	31,000	0	0
KEZAR LIFE SCIENCES INC	COM	49372L100	21,120,000	3,000,000	SH		DFND	1,2	3,000,000	0	0
KOSMOS ENERGY LTD	COM	500688106	2,024,388	318,300	SH		DFND	2	318,300	0	0
KRYSTAL BIOTECH INC	COM	501147102	1,449,726	18,300	SH		DFND	2	18,300	0	0
LABORATORY CORP AMER HLDGS	COM NEW	50540R409	784,148	3,330	SH		DFND	2	3,330	0	0
LEGEND BIOTECH CORP	SPONSORED ADS	52490G102	17,711,067	354,789	SH		DFND	2	354,789	0	0
MACROGENICS INC	COM	556099109	335,165	49,950	SH		DFND	2	49,950	0	0
MACROGENICS INC	COM	556099109	59,920,052	8,929,963	SH		DFND	1,2	8,929,963	0	0
MARKETAXESS HLDGS INC	COM	57060D108	184,625	662	SH		DFND	2	662	0	0
MCKESSON CORP	COM	58155Q103	1,095,350	2,920	SH		DFND	2	2,920	0	0
MEDTRONIC PLC	SHS	G5960L103	48,063,602	618,420	SH		DFND	2	618,420	0	0
MERCADOLIBRE INC	COM	58733R102	143,861	170	SH		DFND	2	170	0	0
MERCK & CO INC	COM	58933Y105	749,023	6,751	SH		DFND	2	6,751	0	0
MERSANA THERAPEUTICS INC	COM	59045L106	1,268,104	216,400	SH		DFND	2	216,400	0	0
MERSANA THERAPEUTICS INC	COM	59045L106	23,827,932	4,066,200	SH		DFND	1,2	4,066,200	0	0
MERUS N V	COM	N5749R100	706,979	45,700	SH		DFND	2	45,700	0	0
MODERNA INC	COM	60770K107	14,437,317	80,377	SH		DFND	2	80,377	0	0
MODERNA INC	COM	60770K107	269,780,439	1,501,951	SH		DFND	1,2	1,501,951	0	0
MOLECULAR TEMPLATES INC	COM	608550109	28,208	86,000	SH		DFND	2	86,000	0	0
MOLECULAR TEMPLATES INC	COM	608550109	3,670,977	11,192,003	SH		DFND	1,2	11,192,003	0	0
MOLINA HEALTHCARE INC	COM	60855R100	61,425,543	186,014	SH		DFND	2	186,014	0	0
MYOVANT SCIENCES LTD	COM	G637AM102	1,024,480	38,000	SH		DFND	2	38,000	0	0
MYOVANT SCIENCES LTD	COM	G637AM102	158,326,347	5,872,639	SH		DFND	1,2	5,872,639	0	0
NATERA INC	COM	632307104	6,982,028	173,812	SH		DFND	2	173,812	0	0
NEKTAR THERAPEUTICS	COM	640268108	33,448	14,800	SH		DFND	2	14,800	0	0
NEUROCRINE BIOSCIENCES INC	COM	64125C109	5,171,035	43,294	SH		DFND	2	43,294	0	0
NEUROCRINE BIOSCIENCES INC	COM	64125C109	326,071,200	2,730,000	SH		DFND	1,2	2,730,000	0	0
NEVRO CORP	COM	64157F103	10,329,066	260,835	SH		DFND	2	260,835	0	0
NOVOCURE LTD	ORD SHS	G6674U108	660,000	9,000	SH		DFND	2	9,000	0	0
OLINK HLDG AB	SPONSORED ADS	680710100	6,375,075	251,185	SH		DFND	2	251,185	0	0
OMNICELL COM	COM	68213N109	26,136,921	518,384	SH		DFND	2	518,384	0	0
OPTHEA LTD	SPONSORED ADS	68386J208	234,601	47,000	SH		DFND	2	47,000	0	0
OPTION CARE HEALTH INC	COM NEW	68404L201	73,131,398	2,430,422	SH		DFND	3	2,430,422	0	0
OUTSET MED INC	COM	690145107	25,999,578	1,006,955	SH		DFND	2	1,006,955	0	0
OUTSET MED INC	COM	690145107	47,424,214	1,836,724	SH		DFND	3	1,836,724	0	0
PACIFIC BIOSCIENCES CALIF IN	COM	69404D108	22,892,630	2,798,610	SH		DFND	2	2,798,610	0	0
PACIFIC BIOSCIENCES CALIF IN	COM	69404D108	30,104,977	3,680,315	SH		DFND	3	3,680,315	0	0
PENUMBRA INC	COM	70975L107	50,235,250	225,817	SH		DFND	2	225,817	0	0
PFIZER INC	COM	717081103	40,411,605	788,673	SH		DFND	2	788,673	0	0
PHREESIA INC	COM	71944F106	21,565,319	666,419	SH		DFND	2	666,419	0	0
PRIVIA HEALTH GROUP INC	COM	74276R102	20,454,125	900,666	SH		DFND	2	900,666	0	0
PROCEPT BIOROBOTICS CORP	COM	74276L105	30,802,616	741,517	SH		DFND	2	741,517	0	0
REGENERON PHARMACEUTICALS	COM	75886F107	11,311,520	15,678	SH		DFND	2	15,678	0	0
RELAY THERAPEUTICS INC	COM	75943R102	1,256,454	84,100	SH		DFND	2	84,100	0	0
RELAY THERAPEUTICS INC	COM	75943R102	61,563,557	4,120,720	SH		DFND	1,2	4,120,720	0	0
RESMED INC	COM	761152107	20,453,976	98,275	SH		DFND	2	98,275	0	0
REVOLUTION MEDICINES INC	COM	76155X100	1,848,432	77,600	SH		DFND	2	77,600	0	0
REVOLUTION MEDICINES INC	COM	76155X100	113,801,527	4,777,562	SH		DFND	1,2	4,777,562	0	0
ROCKET PHARMACEUTICALS INC	COM	77313F106	716,262	36,600	SH		DFND	2	36,600	0	0
SAGE THERAPEUTICS INC	COM	78667J108	724,660	19,000	SH		DFND	2	19,000	0	0
SAGE THERAPEUTICS INC	COM	78667J108	112,523,603	2,950,278	SH		DFND	1,2	2,950,278	0	0
SAREPTA THERAPEUTICS INC	COM	803607100	4,046,913	31,231	SH		DFND	2	31,231	0	0
SAREPTA THERAPEUTICS INC	COM	803607100	85,779,109	661,978	SH		DFND	3	661,978	0	0
SCHOLAR ROCK HLDG CORP	COM	80706P103	174,665	19,300	SH		DFND	2	19,300	0	0
SCHOLAR ROCK HLDG CORP	COM	80706P103	19,301,161	2,132,725	SH		DFND	1,2	2,132,725	0	0
SEAGEN INC	COM	81181C104	2,907,667	22,626	SH		DFND	2	22,626	0	0
SEER INC	COM CL A	81578P106	789,571	136,133	SH		DFND	2	136,133	0	0
SHOCKWAVE MED INC	COM	82489T104	50,912,326	247,616	SH		DFND	2	247,616	0	0
SIGHT SCIENCES INC	COM	82657M105	3,597,139	294,606	SH		DFND	2	294,606	0	0
SILK RD MED INC	COM	82710M100	53,511,841	1,012,523	SH		DFND	3	1,012,523	0	0
SPDR S&P 500 ETF TR	TR UNIT	78462F103	688,374	1,800	SH		DFND	2	1,800	0	0
SPDR SER TR	S&P OILGAS EXP	78468R556	529,932	3,900	SH		DFND	2	3,900	0	0
STRYKER CORPORATION	COM	863667101	120,346,291	492,234	SH		DFND	2	492,234	0	0
SUPERNUS PHARMACEUTICALS INC	COM	868459108	3,961,011	111,046	SH		DFND	2	111,046	0	0
TAIWAN SEMICONDUCTOR MFG LTD	SPONSORED ADS	874039100	1,249	770	SH		DFND	2	770	0	0
TANDEM DIABETES CARE INC	COM NEW	875372203	26,554,932	590,766	SH		DFND	2	590,766	0	0
TANDEM DIABETES CARE INC	COM NEW	875372203	53,970,746	1,200,684	SH		DFND	3	1,200,684	0	0
TELADOC HEALTH INC	COM	87918A105	9,230,264	390,286	SH		DFND	2	390,286	0	0
TELEFLEX INCORPORATED	COM	879369106	6,257,226	25,066	SH		DFND	2	25,066	0	0
THERMO FISHER SCIENTIFIC INC	COM	883556102	45,888,447	83,329	SH		DFND	2	83,329	0	0
TRANSMEDICS GROUP INC	COM	89377M109	42,096,620	682,058	SH		DFND	2	682,058	0	0
UNITED MICROELECTRONICS CORP	SPON ADR NEW	910873405	17,867	2,698	SH		DFND	2	2,698	0	0
UNITED THERAPEUTICS CORP DEL	COM	91307C102	58,955	212	SH		DFND	2	212	0	0
UNITEDHEALTH GROUP INC	COM	91324P102	76,235,643	143,792	SH		DFND	2	143,792	0	0
UNITEDHEALTH GROUP INC	COM	91324P102	42,680,550	80,502	SH		DFND	3	80,502	0	0
VANECK ETF TRUST	GOLD MINERS ETF	92189F106	527,344	18,400	SH		DFND	2	18,400	0	0
VANECK ETF TRUST	JUNIOR GOLD MINE	92189F791	178,250	5,000	SH		DFND	2	5,000	0	0
VEEVA SYS INC	CL A COM	922475108	30,058,155	186,257	SH		DFND	2	186,257	0	0
VERTEX PHARMACEUTICALS INC	COM	92532F100	12,773,606	44,233	SH		DFND	2	44,233	0	0
VERTEX PHARMACEUTICALS INC	COM	92532F100	35,020,928	121,272	SH		DFND	3	121,272	0	0
VERTEX PHARMACEUTICALS INC	COM	92532F100	268,716,432	930,523	SH		DFND	1,2	930,523	0	0
VIRIDIAN THERAPEUTICS INC	COM	92790C104	1,346,581	46,100	SH		DFND	2	46,100	0	0
WAVE LIFE SCIENCES LTD	SHS	Y95308105	31,461,206	4,494,458	SH		DFND	1,2	4,494,458	0	0
XENCOR INC	COM	98401F105	661,416	25,400	SH		DFND	2	25,400	0	0
ZAI LAB LTD	ADR	98887Q104	2,837,843	90,000	SH		DFND	2	90,000	0	0
ZIMMER BIOMET HOLDINGS INC	COM	98956P102	33,952,740	266,296	SH		DFND	2	266,296	0	0