Bellevue (BLVGF) 13F-HR Quarterly holdings report by institutional manager

The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

OMB APPROVAL

OMB Number:		3235-0006
Expires:	Oct 31, 2018
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hours per response:		23.8

COLUMN 1	COLUMN 2	COLUMN 3	COLUMN 4	COLUMN 5			COLUMN 6	COLUMN 7	COLUMN 8
			VALUE	SHRS OR	SH/	PUT/	INVESTMENT	OTHER	VOTING AUTHORITY
NAME OF ISSUER	TITLE OF CLASS	CUSIP	(x$1000)	PRN AMT	PRN	CALL	DISCRETION	MANAGER	SOLE	SHARED	NONE
10X GENOMICS INC	CL A COM	88025U109	18,117,579	324,746	SH		DFND	2	324,746	0	0
89BIO INC	COM	282559103	1,020,410	67,000	SH		DFND	2	67,000	0	0
ABBOTT LABS	COM	002824100	166,766,714	1,646,916	SH		DFND	2	1,646,916	0	0
ABBVIE INC	COM	00287Y109	2,737,339	17,176	SH		DFND	2	17,176	0	0
ACCOLADE INC	COM	00437E102	46,308,130	3,220,315	SH		DFND	3	3,220,315	0	0
ACCOLADE INC	COM	00437E102	11,812,969	821,486	SH		DFND	2	821,486	0	0
AGIOS PHARMACEUTICALS INC	COM	00847X104	91,880,000	4,000,000	SH		DFND	1,2	4,000,000	0	0
AGIOS PHARMACEUTICALS INC	COM	00847X104	310,095	13,500	SH		DFND	2	13,500	0	0
AKERO THERAPEUTICS INC	COM	00973Y108	998,586	26,100	SH		DFND	2	26,100	0	0
ALIGN TECHNOLOGY INC	COM	016255101	57,184,720	171,140	SH		DFND	2	171,140	0	0
ALKERMES PLC	SHS	G01767105	1,809,798	64,200	SH		DFND	2	64,200	0	0
ALNYLAM PHARMACEUTICALS INC	COM	02043Q107	171,273,600	855,000	SH		DFND	1,2	855,000	0	0
ALNYLAM PHARMACEUTICALS INC	COM	02043Q107	5,659,040	28,250	SH		DFND	2	28,250	0	0
ALPHABET INC	CAP STK CL C	02079K107	624,000	6,000	SH		DFND	2	6,000	0	0
AMEDISYS INC	COM	023436108	39,716,117	539,988	SH		DFND	3	539,988	0	0
AMEDISYS INC	COM	023436108	193,289	2,628	SH		DFND	2	2,628	0	0
AMERICAN WELL CORP	CL A	03044L105	3,450,740	1,462,178	SH		DFND	2	1,462,178	0	0
AMERISOURCEBERGEN CORP	COM	03073E105	2,547,350	15,910	SH		DFND	2	15,910	0	0
AMGEN INC	COM	031162100	9,275,222	38,367	SH		DFND	2	38,367	0	0
APELLIS PHARMACEUTICALS INC	COM	03753U106	70,833,257	1,073,882	SH		DFND	3	1,073,882	0	0
APELLIS PHARMACEUTICALS INC	COM	03753U106	2,341,580	35,500	SH		DFND	2	35,500	0	0
ARGENX SE	SPONSORED ADR	04016X101	324,889,760	872,000	SH		DFND	1,2	872,000	0	0
ARGENX SE	SPONSORED ADR	04016X101	5,561,874	14,928	SH		DFND	2	14,928	0	0
ARROWHEAD PHARMACEUTICALS IN	COM	04280A100	541,020	21,300	SH		DFND	2	21,300	0	0
ARVINAS INC	COM	04335A105	57,918,400	2,120,000	SH		DFND	1,2	2,120,000	0	0
ARVINAS INC	COM	04335A105	191,240	7,000	SH		DFND	2	7,000	0	0
ASTRAZENECA PLC	SPONSORED ADR	046353108	4,969,756	71,600	SH		DFND	2	71,600	0	0
ATRICURE INC	COM	04963C209	26,827,352	647,222	SH		DFND	3	647,222	0	0
AXONICS INC	COM	05465P101	61,306,835	1,123,659	SH		DFND	3	1,123,659	0	0
AXONICS INC	COM	05465P101	43,004,301	788,202	SH		DFND	2	788,202	0	0
AXSOME THERAPEUTICS INC	COM	05464T104	27,222,468	441,350	SH		DFND	3	441,350	0	0
BAXTER INTL INC	COM	071813109	11,097,784	273,614	SH		DFND	2	273,614	0	0
BEAM THERAPEUTICS INC	COM	07373V105	21,223,365	693,121	SH		DFND	1,2	693,121	0	0
BEAM THERAPEUTICS INC	COM	07373V105	70,426	2,300	SH		DFND	2	2,300	0	0
BECTON DICKINSON & CO	COM	075887109	86,154,564	348,043	SH		DFND	2	348,043	0	0
BEIGENE LTD	SPONSORED ADR	07725L102	12,551,390	58,235	SH		DFND	2	58,235	0	0
BICYCLE THERAPEUTICS PLC	SPONSORED ADS	088786108	1,131,564	53,200	SH		DFND	2	53,200	0	0
BIOGEN INC	COM	09062X103	6,868,453	24,704	SH		DFND	2	24,704	0	0
BIOMARIN PHARMACEUTICAL INC	COM	09061G101	4,710,792	48,445	SH		DFND	2	48,445	0	0
BIONTECH SE	SPONSORED ADS	09075V102	24,475,514	196,480	SH		DFND	2	196,480	0	0
BIO RAD LABS INC	CL A	090572207	54,483,256	113,739	SH		DFND	3	113,739	0	0
BLACK DIAMOND THERAPEUTICS I	COM	09203E105	10,164,116	5,377,839	SH		DFND	1,2	5,377,839	0	0
BLACK DIAMOND THERAPEUTICS I	COM	09203E105	34,020	18,000	SH		DFND	2	18,000	0	0
BOSTON SCIENTIFIC CORP	COM	101137107	172,082,137	3,439,579	SH		DFND	2	3,439,579	0	0
BRIDGEBIO PHARMA INC	COM	10806X102	1,369,508	82,600	SH		DFND	2	82,600	0	0
BRISTOL-MYERS SQUIBB CO	COM	110122108	103,688	1,496	SH		DFND	2	1,496	0	0
CARDINAL HEALTH INC	COM	14149Y108	800,300	10,600	SH		DFND	2	10,600	0	0
CAREDX INC	COM	14167L103	31,433,292	3,439,091	SH		DFND	3	3,439,091	0	0
CASTLE BIOSCIENCES INC	COM	14843C105	21,558,508	948,878	SH		DFND	3	948,878	0	0
CELLDEX THERAPEUTICS INC	COM NEW	15117B202	64,764,000	1,800,000	SH		DFND	1,2	1,800,000	0	0
CENTENE CORP DEL	COM	15135B101	34,723,845	549,341	SH		DFND	2	549,341	0	0
CHARLES RIV LABS INTL INC	COM	159864107	59,909,460	296,846	SH		DFND	3	296,846	0	0
CHARLES RIV LABS INTL INC	COM	159864107	1,130,192	5,600	SH		DFND	2	5,600	0	0
COOPER COS INC	COM NEW	216648402	30,359,022	81,313	SH		DFND	2	81,313	0	0
CRISPR THERAPEUTICS AG	NAMEN AKT	H17182108	39,802,400	880,000	SH		DFND	1,2	880,000	0	0
CRISPR THERAPEUTICS AG	NAMEN AKT	H17182108	895,554	19,800	SH		DFND	2	19,800	0	0
CVS HEALTH CORP	COM	126650100	1,695,308	22,814	SH		DFND	2	22,814	0	0
CYTOKINETICS INC	COM NEW	23282W605	1,907,298	54,200	SH		DFND	2	54,200	0	0
DANAHER CORPORATION	COM	235851102	85,036,028	337,391	SH		DFND	2	337,391	0	0
DENALI THERAPEUTICS INC	COM	24823R105	714,240	31,000	SH		DFND	2	31,000	0	0
DEXCOM INC	COM	252131107	87,725,078	755,079	SH		DFND	2	755,079	0	0
DOXIMITY INC	CL A	26622P107	14,524,988	448,579	SH		DFND	2	448,579	0	0
DR REDDYS LABS LTD	ADR	256135203	5,892,255	103,500	SH		DFND	2	103,500	0	0
EDWARDS LIFESCIENCES CORP	COM	28176E108	86,094,546	1,040,669	SH		DFND	2	1,040,669	0	0
ELEVANCE HEALTH INC	COM	036752103	25,559,458	55,587	SH		DFND	3	55,587	0	0
ELEVANCE HEALTH INC	COM	036752103	17,189,077	37,383	SH		DFND	2	37,383	0	0
LILLY ELI & CO	COM	532457108	3,696,573	10,764	SH		DFND	2	10,764	0	0
EQUINIX INC	COM	29444U700	28,842	40	SH		DFND	2	40	0	0
ESPERION THERAPEUTICS INC NE	COM	29664W105	6,668,562	4,194,064	SH		DFND	1,2	4,194,064	0	0
ESPERION THERAPEUTICS INC NE	COM	29664W105	22,578	14,200	SH		DFND	2	14,200	0	0
ESSA PHARMA INC	COM NEW	29668H708	23,402,362	7,879,583	SH		DFND	1,2	7,879,583	0	0
ESSA PHARMA INC	COM NEW	29668H708	56,430	19,000	SH		DFND	2	19,000	0	0
EVERTEC INC	COM	30040P103	24,941	739	SH		DFND	2	739	0	0
EVOLENT HEALTH INC	CL A	30050B101	58,003,499	1,787,473	SH		DFND	3	1,787,473	0	0
EVOLENT HEALTH INC	CL A	30050B101	13,099,221	403,674	SH		DFND	2	403,674	0	0
EXACT SCIENCES CORP	COM	30063P105	69,477,584	1,024,592	SH		DFND	3	1,024,592	0	0
EXACT SCIENCES CORP	COM	30063P105	13,592,515	200,450	SH		DFND	2	200,450	0	0
EXELIXIS INC	COM	30161Q104	50,466,000	2,600,000	SH		DFND	1,2	2,600,000	0	0
EXELIXIS INC	COM	30161Q104	174,690	9,000	SH		DFND	2	9,000	0	0
FATE THERAPEUTICS INC	COM	31189P102	27,586,740	4,839,779	SH		DFND	1,2	4,839,779	0	0
FATE THERAPEUTICS INC	COM	31189P102	91,200	16,000	SH		DFND	2	16,000	0	0
GENERATION BIO CO	COM	37148K100	15,515,604	3,608,280	SH		DFND	1,2	3,608,280	0	0
GENERATION BIO CO	COM	37148K100	51,600	12,000	SH		DFND	2	12,000	0	0
GILEAD SCIENCES INC	COM	375558103	8,326,537	100,356	SH		DFND	2	100,356	0	0
GLOBUS MED INC	CL A	379577208	36,682,613	647,645	SH		DFND	2	647,645	0	0
GRUPO AEROPORTUARIO DEL SURE	SPON ADR SER B	40051E202	41,373	135	SH		DFND	2	135	0	0
GUARDANT HEALTH INC	COM	40131M109	1,926,698	82,197	SH		DFND	2	82,197	0	0
HALOZYME THERAPEUTICS INC	COM	40637H109	28,352,256	742,400	SH		DFND	2	742,400	0	0
HARMONY BIOSCIENCES HLDGS IN	COM	413197104	19,526,202	598,046	SH		DFND	2	598,046	0	0
HCA HEALTHCARE INC	COM	40412C101	80,102,292	303,786	SH		DFND	2	303,786	0	0
HENRY SCHEIN INC	COM	806407102	85,046	1,043	SH		DFND	2	1,043	0	0
HOLOGIC INC	COM	436440101	23,413,975	290,136	SH		DFND	2	290,136	0	0
HUMANA INC	COM	444859102	33,287,992	68,570	SH		DFND	2	68,570	0	0
HUTCHMED CHINA LTD	SPONSORED ADS	44842L103	23,453,837	1,801,370	SH		DFND	3	1,801,370	0	0
HUTCHMED CHINA LTD	SPONSORED ADS	44842L103	333,312	25,600	SH		DFND	2	25,600	0	0
IDEXX LABS INC	COM	45168D104	55,472,874	110,928	SH		DFND	2	110,928	0	0
ILLUMINA INC	COM	452327109	23,082,215	99,257	SH		DFND	2	99,257	0	0
INCYTE CORP	COM	45337C102	202,356,000	2,800,000	SH		DFND	1,2	2,800,000	0	0
INCYTE CORP	COM	45337C102	2,926,935	40,500	SH		DFND	2	40,500	0	0
INFOSYS LTD	SPONSORED ADR	456788108	19,707	1,130	SH		DFND	2	1,130	0	0
INHIBRX INC	COM	45720L107	560,439	29,700	SH		DFND	2	29,700	0	0
INSMED INC	COM PAR $.01	457669307	56,147,389	3,293,102	SH		DFND	3	3,293,102	0	0
INSPIRE MED SYS INC	COM	457730109	88,260,307	377,068	SH		DFND	2	377,068	0	0
INSULET CORP	COM	45784P101	103,213,542	323,594	SH		DFND	2	323,594	0	0
INTRA-CELLULAR THERAPIES INC	COM	46116X101	174,092,250	3,215,000	SH		DFND	1,2	3,215,000	0	0
INTRA-CELLULAR THERAPIES INC	COM	46116X101	2,869,950	53,000	SH		DFND	2	53,000	0	0
INTUITIVE SURGICAL INC	COM NEW	46120E602	24,757,853	96,911	SH		DFND	3	96,911	0	0
INTUITIVE SURGICAL INC	COM NEW	46120E602	222,737,906	871,875	SH		DFND	2	871,875	0	0
IONIS PHARMACEUTICALS INC	COM	462222100	337,028,200	9,430,000	SH		DFND	1,2	9,430,000	0	0
IONIS PHARMACEUTICALS INC	COM	462222100	2,927,106	81,900	SH		DFND	2	81,900	0	0
IPG PHOTONICS CORP	COM	44980X109	129,476	1,050	SH		DFND	2	1,050	0	0
IQVIA HLDGS INC	COM	46266C105	34,304,149	172,478	SH		DFND	2	172,478	0	0
ISHARES TR	MSCI CHINA ETF	46429B671	204,549	4,100	SH		DFND	2	4,100	0	0
IVERIC BIO INC	COM	46583P102	1,287,057	52,900	SH		DFND	2	52,900	0	0
JAZZ PHARMACEUTICALS PLC	SHS USD	G50871105	45,431,807	310,475	SH		DFND	3	310,475	0	0
JAZZ PHARMACEUTICALS PLC	SHS USD	G50871105	37,955,368	259,382	SH		DFND	2	259,382	0	0
JOHNSON & JOHNSON	COM	478160104	3,550,275	22,905	SH		DFND	2	22,905	0	0
JUMIA TECHNOLOGIES AG	SPONSORED ADS	48138M105	59,220	18,000	SH		DFND	2	18,000	0	0
KARUNA THERAPEUTICS INC	COM	48576A100	1,325,972	7,300	SH		DFND	2	7,300	0	0
KEZAR LIFE SCIENCES INC	COM	49372L100	31,300	10,000	SH		DFND	2	10,000	0	0
KOSMOS ENERGY LTD	COM	500688106	2,368,152	318,300	SH		DFND	2	318,300	0	0
KRYSTAL BIOTECH INC	COM	501147102	1,465,098	18,300	SH		DFND	2	18,300	0	0
LABORATORY CORP AMER HLDGS	COM NEW	50540R409	1,603,187	6,988	SH		DFND	2	6,988	0	0
LEGEND BIOTECH CORP	SPONSORED ADS	52490G102	24,459,788	507,254	SH		DFND	2	507,254	0	0
MACROGENICS INC	COM	556099109	68,688,335	9,579,963	SH		DFND	1,2	9,579,963	0	0
MACROGENICS INC	COM	556099109	214,742	29,950	SH		DFND	2	29,950	0	0
MCKESSON CORP	COM	58155Q103	975,221	2,739	SH		DFND	2	2,739	0	0
MEDTRONIC PLC	SHS	G5960L103	99,100,926	1,229,235	SH		DFND	2	1,229,235	0	0
MERCK & CO INC	COM	58933Y105	752,709	7,075	SH		DFND	2	7,075	0	0
MERSANA THERAPEUTICS INC	COM	59045L106	17,219,745	4,189,719	SH		DFND	1,2	4,189,719	0	0
MERSANA THERAPEUTICS INC	COM	59045L106	451,689	109,900	SH		DFND	2	109,900	0	0
MERUS N V	COM	N5749R100	840,880	45,700	SH		DFND	2	45,700	0	0
MODERNA INC	COM	60770K107	226,530,500	1,475,000	SH		DFND	1,2	1,475,000	0	0
MODERNA INC	COM	60770K107	11,780,507	76,706	SH		DFND	2	76,706	0	0
MOLECULAR TEMPLATES INC	COM	608550109	4,251,842	11,192,003	SH		DFND	1,2	11,192,003	0	0
MOLECULAR TEMPLATES INC	COM	608550109	14,436	38,000	SH		DFND	2	38,000	0	0
MOLINA HEALTHCARE INC	COM	60855R100	38,146,481	142,609	SH		DFND	2	142,609	0	0
NATERA INC	COM	632307104	12,923,668	232,775	SH		DFND	2	232,775	0	0
NEUROCRINE BIOSCIENCES INC	COM	64125C109	262,159,800	2,590,000	SH		DFND	1,2	2,590,000	0	0
NEUROCRINE BIOSCIENCES INC	COM	64125C109	2,358,426	23,300	SH		DFND	2	23,300	0	0
NEVRO CORP	COM	64157F103	7,901,414	218,573	SH		DFND	2	218,573	0	0
OLINK HLDG AB	SPONSORED ADS	680710100	5,398,729	239,624	SH		DFND	2	239,624	0	0
OMNICELL COM	COM	68213N109	27,185,742	463,367	SH		DFND	2	463,367	0	0
OPTHEA LTD	SPONSORED ADS	68386J208	186,120	47,000	SH		DFND	2	47,000	0	0
OPTION CARE HEALTH INC	COM NEW	68404L201	77,588,217	2,442,185	SH		DFND	3	2,442,185	0	0
OUTSET MED INC	COM	690145107	34,956,394	1,899,804	SH		DFND	3	1,899,804	0	0
OUTSET MED INC	COM	690145107	18,527,972	1,006,955	SH		DFND	2	1,006,955	0	0
PACIFIC BIOSCIENCES CALIF IN	COM	69404D108	53,924,980	4,656,734	SH		DFND	3	4,656,734	0	0
PACIFIC BIOSCIENCES CALIF IN	COM	69404D108	27,437,328	2,369,372	SH		DFND	2	2,369,372	0	0
PENUMBRA INC	COM	70975L107	66,376,155	238,172	SH		DFND	2	238,172	0	0
PFIZER INC	COM	717081103	30,220,356	740,695	SH		DFND	2	740,695	0	0
PHREESIA INC	COM	71944F106	20,622,105	638,653	SH		DFND	2	638,653	0	0
PRIVIA HEALTH GROUP INC	COM	74276R102	27,683,001	1,002,644	SH		DFND	2	1,002,644	0	0
PROCEPT BIOROBOTICS CORP	COM	74276L105	21,059,083	741,517	SH		DFND	2	741,517	0	0
QUEST DIAGNOSTICS INC	COM	74834L100	123,088	870	SH		DFND	2	870	0	0
REGENERON PHARMACEUTICALS	COM	75886F107	12,584,698	15,316	SH		DFND	2	15,316	0	0
RELAY THERAPEUTICS INC	COM	75943R102	67,527,000	4,100,000	SH		DFND	1,2	4,100,000	0	0
RELAY THERAPEUTICS INC	COM	75943R102	1,195,722	72,600	SH		DFND	2	72,600	0	0
RESMED INC	COM	761152107	21,521,242	98,275	SH		DFND	2	98,275	0	0
REVOLUTION MEDICINES INC	COM	76155X100	101,260,500	4,675,000	SH		DFND	1,2	4,675,000	0	0
REVOLUTION MEDICINES INC	COM	76155X100	1,579,014	72,900	SH		DFND	2	72,900	0	0
ROCKET PHARMACEUTICALS INC	COM	77313F106	626,958	36,600	SH		DFND	2	36,600	0	0
SAGE THERAPEUTICS INC	COM	78667J108	129,236,800	3,080,000	SH		DFND	1,2	3,080,000	0	0
SAGE THERAPEUTICS INC	COM	78667J108	419,600	10,000	SH		DFND	2	10,000	0	0
SAREPTA THERAPEUTICS INC	COM	803607100	84,962,409	616,429	SH		DFND	3	616,429	0	0
SAREPTA THERAPEUTICS INC	COM	803607100	4,160,399	30,185	SH		DFND	2	30,185	0	0
SCHOLAR ROCK HLDG CORP	COM	80706P103	17,061,800	2,132,725	SH		DFND	1,2	2,132,725	0	0
SCHOLAR ROCK HLDG CORP	COM	80706P103	58,400	7,300	SH		DFND	2	7,300	0	0
SEAGEN INC	COM	81181C104	4,596,069	22,700	SH		DFND	2	22,700	0	0
SEER INC	COM CL A	81578P106	525,473	136,133	SH		DFND	2	136,133	0	0
SHOCKWAVE MED INC	COM	82489T104	61,010,758	281,376	SH		DFND	2	281,376	0	0
SIGHT SCIENCES INC	COM	82657M105	2,502,122	286,284	SH		DFND	2	286,284	0	0
SILK RD MED INC	COM	82710M100	41,858,887	1,069,739	SH		DFND	3	1,069,739	0	0
SPDR S&P 500 ETF TR	TR UNIT	78462F103	736,902	1,800	SH		DFND	2	1,800	0	0
SPDR SER TR	S&P OILGAS EXP	78468R556	497,601	3,900	SH		DFND	2	3,900	0	0
STRYKER CORPORATION	COM	863667101	138,388,434	484,774	SH		DFND	2	484,774	0	0
SUPERNUS PHARMACEUTICALS INC	COM	868459108	4,451,979	122,881	SH		DFND	2	122,881	0	0
TAIWAN SEMICONDUCTOR MFG LTD	SPONSORED ADS	874039100	71,625	770	SH		DFND	2	770	0	0
TANDEM DIABETES CARE INC	COM NEW	875372203	48,964,533	1,205,726	SH		DFND	3	1,205,726	0	0
TANDEM DIABETES CARE INC	COM NEW	875372203	23,880,183	588,037	SH		DFND	2	588,037	0	0
TELADOC HEALTH INC	COM	87918A105	11,207,474	432,721	SH		DFND	2	432,721	0	0
THE CIGNA GROUP	COM	125523100	13,664,722	53,476	SH		DFND	2	53,476	0	0
THERMO FISHER SCIENTIFIC INC	COM	883556102	49,759,751	86,333	SH		DFND	2	86,333	0	0
TRANSMEDICS GROUP INC	COM	89377M109	47,670,823	629,484	SH		DFND	2	629,484	0	0
UNITED MICROELECTRONICS CORP	SPON ADR NEW	910873405	23,634	2,698	SH		DFND	2	2,698	0	0
UNITEDHEALTH GROUP INC	COM	91324P102	38,293,968	81,030	SH		DFND	3	81,030	0	0
UNITEDHEALTH GROUP INC	COM	91324P102	53,771,763	113,781	SH		DFND	2	113,781	0	0
VANECK ETF TRUST	GOLD MINERS ETF	92189F106	1,067,550	33,000	SH		DFND	2	33,000	0	0
VANECK ETF TRUST	JUNIOR GOLD MINE	92189F791	197,500	5,000	SH		DFND	2	5,000	0	0
VEEVA SYS INC	CL A COM	922475108	48,334,013	262,985	SH		DFND	2	262,985	0	0
VENTYX BIOSCIENCES INC	COM	92332V107	854,250	25,500	SH		DFND	2	25,500	0	0
VERONA PHARMA PLC	SPONSORED ADS	925050106	4,632,115	230,683	SH		DFND	3	230,683	0	0
VERONA PHARMA PLC	SPONSORED ADS	925050106	642,560	32,000	SH		DFND	2	32,000	0	0
VERTEX PHARMACEUTICALS INC	COM	92532F100	284,508,210	903,000	SH		DFND	1,2	903,000	0	0
VERTEX PHARMACEUTICALS INC	COM	92532F100	63,288,426	200,871	SH		DFND	3	200,871	0	0
VERTEX PHARMACEUTICALS INC	COM	92532F100	13,177,488	41,824	SH		DFND	2	41,824	0	0
VIRIDIAN THERAPEUTICS INC	COM	92790C104	1,172,784	46,100	SH		DFND	2	46,100	0	0
WAVE LIFE SCIENCES LTD	SHS	Y95308105	19,461,003	4,494,458	SH		DFND	1,2	4,494,458	0	0
XENCOR INC	COM	98401F105	708,406	25,400	SH		DFND	2	25,400	0	0
ZAI LAB LTD	ADR	98887Q104	5,301,644	159,400	SH		DFND	2	159,400	0	0
ZIMMER BIOMET HOLDINGS INC	COM	98956P102	34,272,884	265,270	SH		DFND	2	265,270	0	0
ZOETIS INC	CL A	98978V103	228,522	1,373	SH		DFND	2	1,373	0	0