COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 |
| | | VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY |
NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
10X GENOMICS INC | CL A COM | 88025U109 | 16,405,961 | 293,173 | SH | | DFND | 2 | 293,173 | 0 | 0 |
89BIO INC | COM | 282559103 | 225,634 | 20,200 | SH | | DFND | 2 | 20,200 | 0 | 0 |
ABBOTT LABS | COM | 002824100 | 169,029,656 | 1,535,656 | SH | | DFND | 2 | 1,535,656 | 0 | 0 |
ABBVIE INC | COM | 00287Y109 | 1,042,483 | 6,727 | SH | | DFND | 2 | 6,727 | 0 | 0 |
ACCOLADE INC | COM | 00437E102 | 7,318,882 | 609,399 | SH | | DFND | 2 | 609,399 | 0 | 0 |
ACCOLADE INC | COM | 00437E102 | 46,815,040 | 3,898,005 | SH | | DFND | 3 | 3,898,005 | 0 | 0 |
AGILENT TECHNOLOGIES INC | COM | 00846U101 | 50,468 | 363 | SH | | DFND | 2 | 363 | 0 | 0 |
AGIOS PHARMACEUTICALS INC | COM | 00847X104 | 244,970 | 11,000 | SH | | DFND | 2 | 11,000 | 0 | 0 |
AGIOS PHARMACEUTICALS INC | COM | 00847X104 | 89,080,000 | 4,000,000 | SH | | DFND | 1,2 | 4,000,000 | 0 | 0 |
ALIGN TECHNOLOGY INC | COM | 016255101 | 43,677,518 | 159,407 | SH | | DFND | 2 | 159,407 | 0 | 0 |
ALKERMES PLC | SHS | G01767105 | 1,445,587 | 52,112 | SH | | DFND | 2 | 52,112 | 0 | 0 |
ALNYLAM PHARMACEUTICALS INC | COM | 02043Q107 | 4,903,541 | 25,618 | SH | | DFND | 2 | 25,618 | 0 | 0 |
ALNYLAM PHARMACEUTICALS INC | COM | 02043Q107 | 164,555,177 | 859,700 | SH | | DFND | 1,2 | 859,700 | 0 | 0 |
ALPHABET INC | CAP STK CL C | 02079K107 | 845,580 | 6,000 | SH | | DFND | 2 | 6,000 | 0 | 0 |
AMGEN INC | COM | 031162100 | 9,851,724 | 34,205 | SH | | DFND | 2 | 34,205 | 0 | 0 |
AMNEAL PHARMACEUTICALS INC | COM STK CL A | 03168L105 | 154,603 | 25,470 | SH | | DFND | 2 | 25,470 | 0 | 0 |
APELLIS PHARMACEUTICALS INC | COM | 03753U106 | 1,203,186 | 20,100 | SH | | DFND | 2 | 20,100 | 0 | 0 |
APELLIS PHARMACEUTICALS INC | COM | 03753U106 | 47,989,762 | 801,700 | SH | | DFND | 3 | 801,700 | 0 | 0 |
ARGENX SE | SPONSORED ADR | 04016X101 | 16,820,284 | 44,208 | SH | | DFND | 2 | 44,208 | 0 | 0 |
ARGENX SE | SPONSORED ADR | 04016X101 | 313,854,750 | 825,000 | SH | | DFND | 1,2 | 825,000 | 0 | 0 |
ARVINAS INC | COM | 04335A105 | 543,312 | 13,200 | SH | | DFND | 2 | 13,200 | 0 | 0 |
ARVINAS INC | COM | 04335A105 | 102,674,896 | 2,494,531 | SH | | DFND | 1,2 | 2,494,531 | 0 | 0 |
ASTRAZENECA PLC | SPONSORED ADR | 046353108 | 3,475,260 | 51,600 | SH | | DFND | 2 | 51,600 | 0 | 0 |
ATRICURE INC | COM | 04963C209 | 29,190,244 | 817,883 | SH | | DFND | 3 | 817,883 | 0 | 0 |
AUTOLUS THERAPEUTICS PLC | SPON ADS | 05280R100 | 322,000 | 50,000 | SH | | DFND | 2 | 50,000 | 0 | 0 |
AXONICS INC | COM | 05465P101 | 50,297,771 | 808,256 | SH | | DFND | 2 | 808,256 | 0 | 0 |
AXONICS INC | COM | 05465P101 | 63,780,087 | 1,024,909 | SH | | DFND | 3 | 1,024,909 | 0 | 0 |
AXSOME THERAPEUTICS INC | COM | 05464T104 | 50,569,257 | 635,372 | SH | | DFND | 3 | 635,372 | 0 | 0 |
BEAM THERAPEUTICS INC | COM | 07373V105 | 46,274 | 1,700 | SH | | DFND | 2 | 1,700 | 0 | 0 |
BEAM THERAPEUTICS INC | COM | 07373V105 | 18,866,754 | 693,121 | SH | | DFND | 1,2 | 693,121 | 0 | 0 |
BECTON DICKINSON & CO | COM | 075887109 | 94,622,620 | 388,068 | SH | | DFND | 2 | 388,068 | 0 | 0 |
BEIGENE LTD | SPONSORED ADR | 07725L102 | 5,211,752 | 28,600 | SH | | DFND | 2 | 28,600 | 0 | 0 |
BICYCLE THERAPEUTICS PLC | SPONSORED ADS | 088786108 | 361,600 | 20,000 | SH | | DFND | 2 | 20,000 | 0 | 0 |
BIOGEN INC | COM | 09062X103 | 2,195,663 | 8,485 | SH | | DFND | 2 | 8,485 | 0 | 0 |
BIOHAVEN LTD | COM | G1110E107 | 46,010,000 | 1,075,000 | SH | | DFND | 1,2 | 1,075,000 | 0 | 0 |
BIOMARIN PHARMACEUTICAL INC | COM | 09061G101 | 31,411,322 | 325,776 | SH | | DFND | 2 | 325,776 | 0 | 0 |
BIOMEA FUSION INC | COM | 09077A106 | 363,000 | 25,000 | SH | | DFND | 2 | 25,000 | 0 | 0 |
BIO RAD LABS INC | CL A | 090572207 | 45,574,955 | 141,147 | SH | | DFND | 3 | 141,147 | 0 | 0 |
BLACK DIAMOND THERAPEUTICS I | COM | 09203E105 | 50,580 | 18,000 | SH | | DFND | 2 | 18,000 | 0 | 0 |
BLACK DIAMOND THERAPEUTICS I | COM | 09203E105 | 23,935,128 | 8,517,839 | SH | | DFND | 1,2 | 8,517,839 | 0 | 0 |
BOSTON SCIENTIFIC CORP | COM | 101137107 | 183,292,559 | 3,170,603 | SH | | DFND | 2 | 3,170,603 | 0 | 0 |
BRIDGEBIO PHARMA INC | COM | 10806X102 | 1,344,321 | 33,300 | SH | | DFND | 2 | 33,300 | 0 | 0 |
C4 THERAPEUTICS INC | COM STK | 12529R107 | 350,300 | 62,000 | SH | | DFND | 2 | 62,000 | 0 | 0 |
CARDINAL HEALTH INC | COM | 14149Y108 | 352,800 | 3,500 | SH | | DFND | 2 | 3,500 | 0 | 0 |
CAREDX INC | COM | 14167L103 | 47,457,504 | 3,954,792 | SH | | DFND | 3 | 3,954,792 | 0 | 0 |
CASTLE BIOSCIENCES INC | COM | 14843C105 | 26,594,717 | 1,232,378 | SH | | DFND | 3 | 1,232,378 | 0 | 0 |
CELLDEX THERAPEUTICS INC NEW | COM NEW | 15117B202 | 95,830,299 | 2,416,296 | SH | | DFND | 1,2 | 2,416,296 | 0 | 0 |
CENCORA INC | COM | 03073E105 | 25,903,758 | 126,126 | SH | | DFND | 2 | 126,126 | 0 | 0 |
CENTENE CORP DEL | COM | 15135B101 | 13,314,684 | 179,419 | SH | | DFND | 2 | 179,419 | 0 | 0 |
CENTENE CORP DEL | COM | 15135B101 | 19,475,227 | 262,434 | SH | | DFND | 3 | 262,434 | 0 | 0 |
CERTARA INC | COM | 15687V109 | 1,604,472 | 91,215 | SH | | DFND | 2 | 91,215 | 0 | 0 |
CHARLES RIV LABS INTL INC | COM | 159864107 | 51,477,518 | 217,756 | SH | | DFND | 3 | 217,756 | 0 | 0 |
COOPER COS INC | COM NEW | 216648402 | 32,559,842 | 86,037 | SH | | DFND | 2 | 86,037 | 0 | 0 |
CRISPR THERAPEUTICS AG | NAMEN AKT | H17182108 | 1,277,040 | 20,400 | SH | | DFND | 2 | 20,400 | 0 | 0 |
CRISPR THERAPEUTICS AG | NAMEN AKT | H17182108 | 55,088,000 | 880,000 | SH | | DFND | 1,2 | 880,000 | 0 | 0 |
CVS HEALTH CORP | COM | 126650100 | 2,487,477 | 31,503 | SH | | DFND | 2 | 31,503 | 0 | 0 |
CYTOKINETICS INC | COM NEW | 23282W605 | 1,577,961 | 18,900 | SH | | DFND | 2 | 18,900 | 0 | 0 |
DANAHER CORPORATION | COM | 235851102 | 19,504,275 | 84,310 | SH | | DFND | 2 | 84,310 | 0 | 0 |
DAVITA INC | COM | 23918K108 | 398,088 | 3,800 | SH | | DFND | 2 | 3,800 | 0 | 0 |
DEXCOM INC | COM | 252131107 | 101,577,592 | 818,580 | SH | | DFND | 2 | 818,580 | 0 | 0 |
DEXCOM INC | COM | 252131107 | 11,914,253 | 96,013 | SH | | DFND | 3 | 96,013 | 0 | 0 |
DOXIMITY INC | CL A | 26622P107 | 7,403,541 | 264,035 | SH | | DFND | 2 | 264,035 | 0 | 0 |
DR REDDYS LABS LTD | ADR | 256135203 | 4,237,422 | 60,900 | SH | | DFND | 2 | 60,900 | 0 | 0 |
DYNAVAX TECHNOLOGIES CORP | COM NEW | 268158201 | 603,936 | 43,200 | SH | | DFND | 2 | 43,200 | 0 | 0 |
EDWARDS LIFESCIENCES CORP | COM | 28176E108 | 77,698,598 | 1,018,998 | SH | | DFND | 2 | 1,018,998 | 0 | 0 |
ELEVANCE HEALTH INC | COM | 036752103 | 27,505,623 | 58,329 | SH | | DFND | 2 | 58,329 | 0 | 0 |
ELEVANCE HEALTH INC | COM | 036752103 | 23,322,886 | 49,459 | SH | | DFND | 3 | 49,459 | 0 | 0 |
ELI LILLY & CO | COM | 532457108 | 32,767,099 | 56,212 | SH | | DFND | 2 | 56,212 | 0 | 0 |
ENCOMPASS HEALTH CORP | COM | 29261A100 | 793,968 | 11,900 | SH | | DFND | 2 | 11,900 | 0 | 0 |
ESPERION THERAPEUTICS INC NE | COM | 29664W105 | 30,498 | 10,200 | SH | | DFND | 2 | 10,200 | 0 | 0 |
ESPERION THERAPEUTICS INC NE | COM | 29664W105 | 12,540,251 | 4,194,064 | SH | | DFND | 1,2 | 4,194,064 | 0 | 0 |
ESSA PHARMA INC | COM NEW | 29668H708 | 125,400 | 19,000 | SH | | DFND | 2 | 19,000 | 0 | 0 |
ESSA PHARMA INC | COM NEW | 29668H708 | 52,005,248 | 7,879,583 | SH | | DFND | 1,2 | 7,879,583 | 0 | 0 |
EVOLENT HEALTH INC | CL A | 30050B101 | 10,210,696 | 309,134 | SH | | DFND | 2 | 309,134 | 0 | 0 |
EVOLENT HEALTH INC | CL A | 30050B101 | 68,301,350 | 2,067,858 | SH | | DFND | 3 | 2,067,858 | 0 | 0 |
EXACT SCIENCES CORP | COM | 30063P105 | 15,933,590 | 215,377 | SH | | DFND | 2 | 215,377 | 0 | 0 |
EXACT SCIENCES CORP | COM | 30063P105 | 61,581,618 | 832,409 | SH | | DFND | 3 | 832,409 | 0 | 0 |
EXELIXIS INC | COM | 30161Q104 | 2,593,319 | 108,100 | SH | | DFND | 2 | 108,100 | 0 | 0 |
EXELIXIS INC | COM | 30161Q104 | 47,980,000 | 2,000,000 | SH | | DFND | 1,2 | 2,000,000 | 0 | 0 |
EXSCIENTIA PLC | COM | 30223G102 | 11,314 | 1,765 | SH | | DFND | 2 | 1,765 | 0 | 0 |
FATE THERAPEUTICS INC | COM | 31189P102 | 44,132 | 11,800 | SH | | DFND | 2 | 11,800 | 0 | 0 |
FATE THERAPEUTICS INC | COM | 31189P102 | 18,100,773 | 4,839,779 | SH | | DFND | 1,2 | 4,839,779 | 0 | 0 |
GE HEALTHCARE TECHNOLOGIES I | COMMON STOCK | 36266G107 | 41,380,427 | 535,184 | SH | | DFND | 2 | 535,184 | 0 | 0 |
GENERATION BIO CO | COM | 37148K100 | 14,520 | 8,800 | SH | | DFND | 2 | 8,800 | 0 | 0 |
GENERATION BIO CO | COM | 37148K100 | 5,953,662 | 3,608,280 | SH | | DFND | 1,2 | 3,608,280 | 0 | 0 |
GILEAD SCIENCES INC | COM | 375558103 | 4,156,218 | 51,305 | SH | | DFND | 2 | 51,305 | 0 | 0 |
GLOBUS MED INC | CL A | 379577208 | 32,388,170 | 607,772 | SH | | DFND | 2 | 607,772 | 0 | 0 |
HCA HEALTHCARE INC | COM | 40412C101 | 41,191,541 | 152,178 | SH | | DFND | 2 | 152,178 | 0 | 0 |
HOLOGIC INC | COM | 436440101 | 20,710,783 | 289,864 | SH | | DFND | 2 | 289,864 | 0 | 0 |
HUMANA INC | COM | 444859102 | 45,997,086 | 100,472 | SH | | DFND | 2 | 100,472 | 0 | 0 |
HUTCHMED CHINA LTD | SPONSORED ADS | 44842L103 | 1,045,506 | 58,000 | SH | | DFND | 2 | 58,000 | 0 | 0 |
HUTCHMED CHINA LTD | SPONSORED ADS | 44842L103 | 19,343,856 | 1,073,111 | SH | | DFND | 3 | 1,073,111 | 0 | 0 |
IDEXX LABS INC | COM | 45168D104 | 52,235,756 | 94,110 | SH | | DFND | 2 | 94,110 | 0 | 0 |
ILLUMINA INC | COM | 452327109 | 6,264,825 | 44,993 | SH | | DFND | 2 | 44,993 | 0 | 0 |
IMMUNOCORE HLDGS PLC | ADS | 45258D105 | 710,528 | 10,400 | SH | | DFND | 2 | 10,400 | 0 | 0 |
IMMUNOCORE HLDGS PLC | ADS | 45258D105 | 65,973,481 | 965,654 | SH | | DFND | 1,2 | 965,654 | 0 | 0 |
INCYTE CORP | COM | 45337C102 | 421,886 | 6,719 | SH | | DFND | 2 | 6,719 | 0 | 0 |
INCYTE CORP | COM | 45337C102 | 134,998,500 | 2,150,000 | SH | | DFND | 1,2 | 2,150,000 | 0 | 0 |
INHIBRX INC | COM | 45720L107 | 934,800 | 24,600 | SH | | DFND | 2 | 24,600 | 0 | 0 |
INSMED INC | COM PAR $.01 | 457669307 | 1,196,214 | 38,600 | SH | | DFND | 2 | 38,600 | 0 | 0 |
INSMED INC | COM PAR $.01 | 457669307 | 69,800,574 | 2,252,358 | SH | | DFND | 3 | 2,252,358 | 0 | 0 |
INSPIRE MED SYS INC | COM | 457730109 | 18,445,405 | 90,672 | SH | | DFND | 2 | 90,672 | 0 | 0 |
INSPIRE MED SYS INC | COM | 457730109 | 25,414,103 | 124,928 | SH | | DFND | 3 | 124,928 | 0 | 0 |
INSULET CORP | COM | 45784P101 | 62,902,502 | 289,900 | SH | | DFND | 2 | 289,900 | 0 | 0 |
INTRA-CELLULAR THERAPIES INC | COM | 46116X101 | 1,890,768 | 26,400 | SH | | DFND | 2 | 26,400 | 0 | 0 |
INTRA-CELLULAR THERAPIES INC | COM | 46116X101 | 217,724,800 | 3,040,000 | SH | | DFND | 1,2 | 3,040,000 | 0 | 0 |
INTUITIVE SURGICAL INC | COM NEW | 46120E602 | 234,521,876 | 695,168 | SH | | DFND | 2 | 695,168 | 0 | 0 |
INTUITIVE SURGICAL INC | COM NEW | 46120E602 | 46,175,475 | 136,873 | SH | | DFND | 3 | 136,873 | 0 | 0 |
IONIS PHARMACEUTICALS INC | COM | 462222100 | 6,272,502 | 123,987 | SH | | DFND | 2 | 123,987 | 0 | 0 |
IONIS PHARMACEUTICALS INC | COM | 462222100 | 434,568,100 | 8,590,000 | SH | | DFND | 1,2 | 8,590,000 | 0 | 0 |
IONQ INC | COM | 46222L108 | 9,181 | 741 | SH | | DFND | 2 | 741 | 0 | 0 |
IQVIA HLGS INC | COM | 46266C105 | 1,911,199 | 8,260 | SH | | DFND | 2 | 8,260 | 0 | 0 |
ISHARES TR | MSCI CHINA ETF | 46429B671 | 167,034 | 4,100 | SH | | DFND | 2 | 4,100 | 0 | 0 |
JOHNSON & JOHNSON | COM | 478160104 | 4,432,607 | 28,280 | SH | | DFND | 2 | 28,280 | 0 | 0 |
KARUNA THERAPEUTICS INC | COM | 48576A100 | 1,930,711 | 6,100 | SH | | DFND | 2 | 6,100 | 0 | 0 |
KOSMOS ENERGY LTD | COM | 500688106 | 1,721,115 | 256,500 | SH | | DFND | 2 | 256,500 | 0 | 0 |
KRYSTAL BIOTECH INC | COM | 501147102 | 992,480 | 8,000 | SH | | DFND | 2 | 8,000 | 0 | 0 |
LABORATORY CORP AMER HLDGS | COM NEW | 50540R409 | 1,611,259 | 7,089 | SH | �� | DFND | 2 | 7,089 | 0 | 0 |
LEGEND BIOTECH CORP | SPONSORED ADS | 52490G102 | 12,139,538 | 201,754 | SH | | DFND | 2 | 201,754 | 0 | 0 |
LIFE TIME GROUP HOLDINGS INC | COMMON STOCK | 53190C102 | 380,016 | 25,200 | SH | | DFND | 2 | 25,200 | 0 | 0 |
LULULEMON ATHLETICA INC | COM | 550021109 | 393,693 | 770 | SH | | DFND | 2 | 770 | 0 | 0 |
MACROGENICS INC | COM | 556099109 | 224,627 | 23,350 | SH | | DFND | 2 | 23,350 | 0 | 0 |
MACROGENICS INC | COM | 556099109 | 95,526,244 | 9,929,963 | SH | | DFND | 1,2 | 9,929,963 | 0 | 0 |
MCKESSON CORP | COM | 58155Q103 | 2,246,842 | 4,853 | SH | | DFND | 2 | 4,853 | 0 | 0 |
MEDTRONIC PLC | SHS | G5960L103 | 79,972,197 | 970,772 | SH | | DFND | 2 | 970,772 | 0 | 0 |
MERCK & CO INC | COM | 58933Y105 | 31,638,258 | 290,206 | SH | | DFND | 2 | 290,206 | 0 | 0 |
MERUS N V | COM | N5749R100 | 624,250 | 22,700 | SH | | DFND | 2 | 22,700 | 0 | 0 |
METTLER TOLEDO INTERNATIONAL | COM | 592688105 | 30,324 | 25 | SH | | DFND | 2 | 25 | 0 | 0 |
MICROSOFT CORP | COM | 594918104 | 45,877 | 122 | SH | | DFND | 2 | 122 | 0 | 0 |
MODERNA INC | COM | 60770K107 | 1,724,960 | 17,345 | SH | | DFND | 2 | 17,345 | 0 | 0 |
MODERNA INC | COM | 60770K107 | 188,067,409 | 1,891,075 | SH | | DFND | 1,2 | 1,891,075 | 0 | 0 |
MOLECULAR TEMPLATES INC | COM NEW | 608550208 | 3,841,229 | 1,029,820 | SH | | DFND | 1,2 | 1,029,820 | 0 | 0 |
MOLINA HEALTHCARE INC | COM | 60855R100 | 33,051,194 | 91,476 | SH | | DFND | 2 | 91,476 | 0 | 0 |
NATERA INC | COM | 632307104 | 16,072,422 | 256,584 | SH | | DFND | 2 | 256,584 | 0 | 0 |
NEUROCRINE BIOSCIENCES INC | COM | 64125C109 | 2,701,080 | 20,500 | SH | | DFND | 2 | 20,500 | 0 | 0 |
NEUROCRINE BIOSCIENCES INC | COM | 64125C109 | 317,541,600 | 2,410,000 | SH | | DFND | 1,2 | 2,410,000 | 0 | 0 |
NEVRO CORP | COM | 64157F103 | 4,246,412 | 197,324 | SH | | DFND | 2 | 197,324 | 0 | 0 |
NIKE INC | CL B | 654106103 | 369,138 | 3,400 | SH | | DFND | 2 | 3,400 | 0 | 0 |
NVIDIA CORPORATION | COM | 67066G104 | 49,027 | 99 | SH | | DFND | 2 | 99 | 0 | 0 |
OMNICELL INC | COM | 68213N109 | 8,422,196 | 223,816 | SH | | DFND | 2 | 223,816 | 0 | 0 |
OPTION CARE HEALTH INC | COM NEW | 68404L201 | 65,318,408 | 1,938,807 | SH | | DFND | 3 | 1,938,807 | 0 | 0 |
ORACLE CORP | COM | 68389X105 | 47,865 | 454 | SH | | DFND | 2 | 454 | 0 | 0 |
OUTSET MEDICAL INC | COM | 690145107 | 2,944,425 | 544,256 | SH | | DFND | 2 | 544,256 | 0 | 0 |
OUTSET MEDICAL INC | COM | 690145107 | 6,577,900 | 1,215,878 | SH | | DFND | 3 | 1,215,878 | 0 | 0 |
PACIFIC BIOSCIENCES CALIF IN | COM | 69404D108 | 18,150,540 | 1,850,208 | SH | | DFND | 2 | 1,850,208 | 0 | 0 |
PACIFIC BIOSCIENCES CALIF IN | COM | 69404D108 | 53,630,485 | 5,466,920 | SH | | DFND | 3 | 5,466,920 | 0 | 0 |
PENUMBRA INC | COM | 70975L107 | 51,074,191 | 203,046 | SH | | DFND | 2 | 203,046 | 0 | 0 |
PFIZER INC | COM | 717081103 | 658,370 | 22,868 | SH | | DFND | 2 | 22,868 | 0 | 0 |
PHREESIA INC | COM | 71944F106 | 9,759,415 | 421,573 | SH | | DFND | 2 | 421,573 | 0 | 0 |
PRIVIA HEALTH GROUP INC | COM | 74276R102 | 24,220,559 | 1,051,696 | SH | | DFND | 2 | 1,051,696 | 0 | 0 |
PROCEPT BIOROBOTICS CORP | COM | 74276L105 | 37,104,851 | 885,346 | SH | | DFND | 2 | 885,346 | 0 | 0 |
PROTAGONIST THERAPEUTICS INC | COM | 74366E102 | 687,900 | 30,000 | SH | | DFND | 2 | 30,000 | 0 | 0 |
QUALCOMM INC | COM | 747525103 | 50,187 | 347 | SH | | DFND | 2 | 347 | 0 | 0 |
RECURSION PHARMACEUTICALS IN | CL A | 75629V104 | 1,721,132 | 174,557 | SH | | DFND | 2 | 174,557 | 0 | 0 |
REGENERON PHARMACEUTICALS | COM | 75886F107 | 9,405,608 | 10,709 | SH | | DFND | 2 | 10,709 | 0 | 0 |
RELAY THERAPEUTICS INC | COM | 75943R102 | 122,013 | 11,082 | SH | | DFND | 2 | 11,082 | 0 | 0 |
RELAY THERAPEUTICS INC | COM | 75943R102 | 65,234,250 | 5,925,000 | SH | | DFND | 1,2 | 5,925,000 | 0 | 0 |
RESMED INC | COM | 761152107 | 5,215,646 | 30,320 | SH | | DFND | 2 | 30,320 | 0 | 0 |
REVOLUTION MEDICINES INC | COM | 76155X100 | 1,270,524 | 44,300 | SH | | DFND | 2 | 44,300 | 0 | 0 |
REVOLUTION MEDICINES INC | COM | 76155X100 | 144,739,356 | 5,046,700 | SH | | DFND | 1,2 | 5,046,700 | 0 | 0 |
RHYTHM PHARMACEUTICALS INC | COM | 76243J105 | 1,510,988 | 32,869 | SH | | DFND | 2 | 32,869 | 0 | 0 |
ROCKET PHARMACEUTICALS INC | COM | 77313F106 | 629,370 | 21,000 | SH | | DFND | 2 | 21,000 | 0 | 0 |
SAGE THERAPEUTICS INC | COM | 78667J108 | 180,966 | 8,351 | SH | | DFND | 2 | 8,351 | 0 | 0 |
SAGE THERAPEUTICS INC | COM | 78667J108 | 75,953,350 | 3,505,000 | SH | | DFND | 1,2 | 3,505,000 | 0 | 0 |
SAREPTA THERAPEUTICS INC | COM | 803607100 | 540,008 | 5,600 | SH | | DFND | 2 | 5,600 | 0 | 0 |
SAREPTA THERAPEUTICS INC | COM | 803607100 | 22,341,481 | 231,686 | SH | | DFND | 3 | 231,686 | 0 | 0 |
SCHOLAR ROCK HLDG CORP | COM | 80706P103 | 680,560 | 36,200 | SH | | DFND | 2 | 36,200 | 0 | 0 |
SCHOLAR ROCK HLDG CORP | COM | 80706P103 | 40,095,230 | 2,132,725 | SH | | DFND | 1,2 | 2,132,725 | 0 | 0 |
SHOCKWAVE MED INC | COM | 82489T104 | 23,783,794 | 124,810 | SH | | DFND | 2 | 124,810 | 0 | 0 |
SI-BONE INC | COM | 825704109 | 2,627,948 | 125,200 | SH | | DFND | 3 | 125,200 | 0 | 0 |
SILK RD MED INC | COM | 82710M100 | 17,615,818 | 1,435,682 | SH | | DFND | 3 | 1,435,682 | 0 | 0 |
SPDR S&P 500 ETF TR | TR UNIT | 78462F103 | 1,235,806 | 2,600 | SH | | DFND | 2 | 2,600 | 0 | 0 |
SPDR SER TR | S&P OILGAS EXP | 78468R556 | 533,949 | 3,900 | SH | | DFND | 2 | 3,900 | 0 | 0 |
STRUCTURE THERAPEUTICS INC | SPONSORED ADS | 86366E106 | 501,348 | 12,300 | SH | | DFND | 2 | 12,300 | 0 | 0 |
STRYKER CORPORATION | COM | 863667101 | 139,465,709 | 465,724 | SH | | DFND | 2 | 465,724 | 0 | 0 |
SUPERNUS PHARMACEUTICALS INC | COM | 868459108 | 436,994 | 15,100 | SH | | DFND | 2 | 15,100 | 0 | 0 |
TANDEM DIABETES CARE INC | COM NEW | 875372203 | 58,932,737 | 1,992,317 | SH | | DFND | 3 | 1,992,317 | 0 | 0 |
TELADOC HEALTH INC | COM | 87918A105 | 5,590,156 | 259,404 | SH | | DFND | 2 | 259,404 | 0 | 0 |
TENET HEALTHCARE CORP | COM NEW | 88033G407 | 109,350 | 1,447 | SH | | DFND | 2 | 1,447 | 0 | 0 |
THE CIGNA GROUP | COM | 125523100 | 26,492,342 | 88,470 | SH | | DFND | 2 | 88,470 | 0 | 0 |
THERMO FISHER SCIENTIFIC INC | COM | 883556102 | 18,759,180 | 35,342 | SH | | DFND | 2 | 35,342 | 0 | 0 |
TRANSMEDICS GROUP INC | COM | 89377M109 | 40,955,988 | 518,890 | SH | | DFND | 2 | 518,890 | 0 | 0 |
UNITEDHEALTH GROUP INC | COM | 91324P102 | 46,428,336 | 88,188 | SH | | DFND | 2 | 88,188 | 0 | 0 |
UNITEDHEALTH GROUP INC | COM | 91324P102 | 26,304,547 | 49,964 | SH | | DFND | 3 | 49,964 | 0 | 0 |
VANECK ETF TRUST | GOLD MINERS ETF | 92189F106 | 1,023,330 | 33,000 | SH | | DFND | 2 | 33,000 | 0 | 0 |
VANECK ETF TRUST | JUNIOR GOLD MINE | 92189F791 | 189,550 | 5,000 | SH | | DFND | 2 | 5,000 | 0 | 0 |
VAXCYTE INC | COM | 92243G108 | 992,240 | 15,800 | SH | | DFND | 2 | 15,800 | 0 | 0 |
VEEVA SYS INC | CL A COM | 922475108 | 37,543,903 | 195,013 | SH | | DFND | 2 | 195,013 | 0 | 0 |
VERONA PHARMA PLC | SPONSORED ADS | 925050106 | 755,440 | 38,000 | SH | | DFND | 2 | 38,000 | 0 | 0 |
VERONA PHARMA PLC | SPONSORED ADS | 925050106 | 15,943,680 | 801,996 | SH | | DFND | 3 | 801,996 | 0 | 0 |
VERTEX PHARMACEUTICALS INC | COM | 92532F100 | 39,220,127 | 96,390 | SH | | DFND | 2 | 96,390 | 0 | 0 |
VERTEX PHARMACEUTICALS INC | COM | 92532F100 | 260,409,600 | 640,000 | SH | | DFND | 1,2 | 640,000 | 0 | 0 |
VERVE THERAPEUTICS INC | COM | 92539P101 | 543,660 | 39,000 | SH | | DFND | 2 | 39,000 | 0 | 0 |
VIATRIS INC | COM | 92556V106 | 194,972 | 18,003 | SH | | DFND | 2 | 18,003 | 0 | 0 |
VIKING THERAPEUTICS INC | COM | 92686J106 | 325,675 | 17,500 | SH | | DFND | 2 | 17,500 | 0 | 0 |
VIRIDIAN THERAPEUTICS INC | COM | 92790C104 | 653,400 | 30,000 | SH | | DFND | 2 | 30,000 | 0 | 0 |
WAVE LIFE SCIENCES LTD | SHS | Y95308105 | 22,697,013 | 4,494,458 | SH | | DFND | 1,2 | 4,494,458 | 0 | 0 |
WW INTL INC | COM | 98262P101 | 350,000 | 40,000 | SH | | DFND | 2 | 40,000 | 0 | 0 |
XENON PHARMACEUTICALS INC | COM | 98420N105 | 1,013,320 | 22,000 | SH | | DFND | 2 | 22,000 | 0 | 0 |
ZAI LAB LTD | ADR | 98887Q104 | 3,714,332 | 135,000 | SH | | DFND | 2 | 135,000 | 0 | 0 |
ZIMMER BIOMET HOLDINGS INC | COM | 98956P102 | 34,208,410 | 281,088 | SH | | DFND | 2 | 281,088 | 0 | 0 |
ZOETIS INC | CL A | 98978V103 | 1,142,772 | 5,790 | SH | | DFND | 2 | 5,790 | 0 | 0 |