Bellevue (BLVGF) 13F-HR Quarterly holdings report by institutional manager

The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

OMB APPROVAL

OMB Number:		3235-0006
Expires:	Oct 31, 2018
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COLUMN 1	COLUMN 2	COLUMN 3	COLUMN 4	COLUMN 5			COLUMN 6	COLUMN 7	COLUMN 8
			VALUE	SHRS OR	SH/	PUT/	INVESTMENT	OTHER	VOTING AUTHORITY
NAME OF ISSUER	TITLE OF CLASS	CUSIP	(x$1000)	PRN AMT	PRN	CALL	DISCRETION	MANAGER	SOLE	SHARED	NONE
10X GENOMICS INC	CL A COM	88025U109	11,570,912	308,311	SH		DFND	2	308,311	0	0
4D MOLECULAR THERAPEUTICS IN	COM	35104E100	500,202	15,700	SH		DFND	2	15,700	0	0
89BIO INC	COM	282559103	159,468	13,700	SH		DFND	2	13,700	0	0
ABBOTT LABS	COM	002824100	163,009,240	1,434,183	SH		DFND	2	1,434,183	0	0
ABBVIE INC	COM	00287Y109	5,024,685	27,593	SH		DFND	2	27,593	0	0
ACCOLADE INC	COM	00437E102	6,716,265	640,865	SH		DFND	2	640,865	0	0
ACCOLADE INC	COM	00437E102	43,635,042	4,163,649	SH		DFND	3	4,163,649	0	0
ADMA BIOLOGICS INC	COM	000899104	269,940	40,900	SH		DFND	2	40,900	0	0
AGILENT TECHNOLOGIES INC	COM	00846U101	78,575	540	SH		DFND	2	540	0	0
AGIOS PHARMACEUTICALS INC	COM	00847X104	175,440	6,000	SH		DFND	2	6,000	0	0
AGIOS PHARMACEUTICALS INC	COM	00847X104	116,960,000	4,000,000	SH		DFND	1,2	4,000,000	0	0
ALIGN TECHNOLOGY INC	COM	016255101	50,797,759	154,909	SH		DFND	2	154,909	0	0
ALKERMES PLC	SHS	G01767105	653,578	24,144	SH		DFND	2	24,144	0	0
ALNYLAM PHARMACEUTICALS INC	COM	02043Q107	1,282,879	8,584	SH		DFND	2	8,584	0	0
ALNYLAM PHARMACEUTICALS INC	COM	02043Q107	135,954,665	909,700	SH		DFND	1,2	909,700	0	0
ALPHABET INC	CAP STK CL C	02079K107	913,560	6,000	SH		DFND	2	6,000	0	0
AMGEN INC	COM	031162100	6,294,560	22,139	SH		DFND	2	22,139	0	0
AMNEAL PHARMACEUTICALS INC	COM STK CL A	03168L105	275,045	45,387	SH		DFND	2	45,387	0	0
ANNEXON INC	COM	03589W102	15,647,019	2,182,290	SH		DFND	1,2	2,182,290	0	0
APELLIS PHARMACEUTICALS INC	COM	03753U106	717,998	12,215	SH		DFND	2	12,215	0	0
APELLIS PHARMACEUTICALS INC	COM	03753U106	27,138,726	461,700	SH		DFND	3	461,700	0	0
APPLE INC	COM	037833100	377,256	2,200	SH		DFND	2	2,200	0	0
ARGENX SE	SPONSORED ADR	04016X101	16,148,820	41,016	SH		DFND	2	41,016	0	0
ARGENX SE	SPONSORED ADR	04016X101	303,164,400	770,000	SH		DFND	1,2	770,000	0	0
ARVINAS INC	COM	04335A105	445,824	10,800	SH		DFND	2	10,800	0	0
ARVINAS INC	COM	04335A105	98,246,400	2,380,000	SH		DFND	1,2	2,380,000	0	0
ASTRANA HEALTH INC	COM NEW	03763A207	430,649	10,256	SH		DFND	3	10,256	0	0
ASTRAZENECA PLC	SPONSORED ADR	046353108	1,571,800	23,200	SH		DFND	2	23,200	0	0
ATRICURE INC	COM	04963C209	13,609,178	447,376	SH		DFND	3	447,376	0	0
AUTOLUS THERAPEUTICS PLC	SPON ADS	05280R100	207,350	32,500	SH		DFND	2	32,500	0	0
AXSOME THERAPEUTICS INC	COM	05464T104	287,280	3,600	SH		DFND	2	3,600	0	0
AXSOME THERAPEUTICS INC	COM	05464T104	54,413,705	681,876	SH		DFND	3	681,876	0	0
BAIDU INC	SPON ADR REP A	056752108	210,560	2,000	SH		DFND	2	2,000	0	0
BAXTER INTL INC	COM	071813109	179,508	4,200	SH		DFND	2	4,200	0	0
BEAM THERAPEUTICS INC	COM	07373V105	39,420,718	1,193,121	SH		DFND	1,2	1,193,121	0	0
BECTON DICKINSON & CO	COM	075887109	102,864,965	415,700	SH		DFND	2	415,700	0	0
BEIGENE LTD	SPONSORED ADR	07725L102	3,898,646	24,929	SH		DFND	2	24,929	0	0
BICYCLE THERAPEUTICS PLC	SPONSORED ADS	088786108	311,250	12,500	SH		DFND	2	12,500	0	0
BIO RAD LABS INC	CL A	090572207	54,169,468	156,618	SH		DFND	3	156,618	0	0
BIOGEN INC	COM	09062X103	1,295,505	6,008	SH		DFND	2	6,008	0	0
BIOHAVEN LTD	COM	G1110E107	62,893,500	1,150,000	SH		DFND	1,2	1,150,000	0	0
BIOMARIN PHARMACEUTICAL INC	COM	09061G101	28,104,877	321,787	SH		DFND	2	321,787	0	0
BIOMEA FUSION INC	COM	09077A106	266,110	17,800	SH		DFND	2	17,800	0	0
BLACK DIAMOND THERAPEUTICS I	COM	09203E105	43,185,444	8,517,839	SH		DFND	1,2	8,517,839	0	0
BLUEPRINT MEDICINES CORP	COM	09627Y109	483,786	5,100	SH		DFND	2	5,100	0	0
BOSTON SCIENTIFIC CORP	COM	101137107	215,652,819	3,148,676	SH		DFND	2	3,148,676	0	0
BRIDGEBIO PHARMA INC	COM	10806X102	395,776	12,800	SH		DFND	2	12,800	0	0
BRISTOL-MYERS SQUIBB CO	COM	110122108	1,270,934	23,436	SH		DFND	2	23,436	0	0
C4 THERAPEUTICS INC	COM STK	12529R107	470,592	57,600	SH		DFND	2	57,600	0	0
CARDINAL HEALTH INC	COM	14149Y108	335,700	3,000	SH		DFND	2	3,000	0	0
CAREDX INC	COM	14167L103	41,661,124	3,934,006	SH		DFND	3	3,934,006	0	0
CASTLE BIOSCIENCES INC	COM	14843C105	27,024,883	1,220,085	SH		DFND	3	1,220,085	0	0
CELLDEX THERAPEUTICS INC NEW	COM NEW	15117B202	117,373,932	2,796,615	SH		DFND	1,2	2,796,615	0	0
CENCORA INC	COM	03073E105	31,954,157	131,504	SH		DFND	2	131,504	0	0
CENTENE CORP DEL	COM	15135B101	12,489,857	159,147	SH		DFND	2	159,147	0	0
CENTENE CORP DEL	COM	15135B101	16,006,231	203,953	SH		DFND	3	203,953	0	0
CERTARA INC	COM	15687V109	1,715,121	95,924	SH		DFND	2	95,924	0	0
CHARLES RIV LABS INTL INC	COM	159864107	525,643	1,940	SH		DFND	2	1,940	0	0
CHARLES RIV LABS INTL INC	COM	159864107	61,710,759	227,757	SH		DFND	3	227,757	0	0
COOPER COS INC	COM	216648501	40,317,465	397,373	SH		DFND	2	397,373	0	0
CRISPR THERAPEUTICS AG	NAMEN AKT	H17182108	678,192	9,950	SH		DFND	2	9,950	0	0
CRISPR THERAPEUTICS AG	NAMEN AKT	H17182108	41,577,600	610,000	SH		DFND	1,2	610,000	0	0
CVS HEALTH CORP	COM	126650100	1,759,984	22,066	SH		DFND	2	22,066	0	0
CYTOKINETICS INC	COM NEW	23282W605	1,096,520	15,640	SH		DFND	2	15,640	0	0
DANAHER CORPORATION	COM	235851102	21,533,855	86,232	SH		DFND	2	86,232	0	0
DEXCOM INC	COM	252131107	113,313,739	816,970	SH		DFND	2	816,970	0	0
DEXCOM INC	COM	252131107	56,066,285	404,227	SH		DFND	3	404,227	0	0
DOXIMITY INC	CL A	26622P107	3,876,789	144,065	SH		DFND	2	144,065	0	0
DR REDDYS LABS LTD	ADR	256135203	2,999,722	40,896	SH		DFND	2	40,896	0	0
DYNAVAX TECHNOLOGIES CORP	COM NEW	268158201	341,995	27,558	SH		DFND	2	27,558	0	0
EDWARDS LIFESCIENCES CORP	COM	28176E108	89,043,190	931,804	SH		DFND	2	931,804	0	0
EDWARDS LIFESCIENCES CORP	COM	28176E108	16,372,486	171,332	SH		DFND	3	171,332	0	0
ELEVANCE HEALTH INC	COM	036752103	28,752,524	55,449	SH		DFND	2	55,449	0	0
ELEVANCE HEALTH INC	COM	036752103	22,381,742	43,163	SH		DFND	3	43,163	0	0
ELI LILLY & CO	COM	532457108	45,094,451	57,965	SH		DFND	2	57,965	0	0
ENCOMPASS HEALTH CORP	COM	29261A100	1,237,048	14,980	SH		DFND	2	14,980	0	0
ESPERION THERAPEUTICS INC NE	COM	29664W105	26,650,092	9,944,064	SH		DFND	1,2	9,944,064	0	0
ESSA PHARMA INC	COM NEW	29668H708	84,900	10,000	SH		DFND	2	10,000	0	0
ESSA PHARMA INC	COM NEW	29668H708	66,897,660	7,879,583	SH		DFND	1,2	7,879,583	0	0
EVOLENT HEALTH INC	CL A	30050B101	10,659,898	325,096	SH		DFND	2	325,096	0	0
EVOLENT HEALTH INC	CL A	30050B101	37,970,820	1,158,000	SH		DFND	3	1,158,000	0	0
EXACT SCIENCES CORP	COM	30063P105	15,808,801	228,914	SH		DFND	2	228,914	0	0
EXACT SCIENCES CORP	COM	30063P105	62,817,805	909,612	SH		DFND	3	909,612	0	0
EXELIXIS INC	COM	30161Q104	75,936	3,200	SH		DFND	2	3,200	0	0
EXELIXIS INC	COM	30161Q104	45,087,000	1,900,000	SH		DFND	1,2	1,900,000	0	0
EXSCIENTIA PLC	ADS	30223G102	15,124	2,644	SH		DFND	2	2,644	0	0
FATE THERAPEUTICS INC	COM	31189P102	35,523,978	4,839,779	SH		DFND	1,2	4,839,779	0	0
GARMIN LTD	SHS	H2906T109	416,836	2,800	SH		DFND	2	2,800	0	0
GE HEALTHCARE TECHNOLOGIES I	COMMON STOCK	36266G107	46,566,829	512,230	SH		DFND	2	512,230	0	0
GENERATION BIO CO	COM	37148K100	15,716,610	3,861,575	SH		DFND	1,2	3,861,575	0	0
GILEAD SCIENCES INC	COM	375558103	2,439,591	33,305	SH		DFND	2	33,305	0	0
GLAUKOS CORP	COM	377322102	5,273,263	55,926	SH		DFND	2	55,926	0	0
GLOBUS MED INC	CL A	379577208	31,105,729	579,898	SH		DFND	2	579,898	0	0
HCA HEALTHCARE INC	COM	40412C101	53,265,742	159,703	SH		DFND	2	159,703	0	0
HOLOGIC INC	COM	436440101	22,605,983	289,969	SH		DFND	2	289,969	0	0
HUMANA INC	COM	444859102	32,543,139	93,860	SH		DFND	2	93,860	0	0
HUMANA INC	COM	444859102	14,451,636	41,681	SH		DFND	3	41,681	0	0
HUTCHMED CHINA LTD	SPONSORED ADS	44842L103	567,336	33,770	SH		DFND	2	33,770	0	0
HUTCHMED CHINA LTD	SPONSORED ADS	44842L103	18,830,482	1,120,862	SH		DFND	3	1,120,862	0	0
IDEAYA BIOSCIENCES INC	COM	45166A102	144,804	3,300	SH		DFND	2	3,300	0	0
IDEXX LABS INC	COM	45168D104	50,406,785	93,358	SH		DFND	2	93,358	0	0
ILLUMINA INC	COM	452327109	5,986,603	43,596	SH		DFND	2	43,596	0	0
IMMUNOCORE HLDGS PLC	ADS	45258D105	429,000	6,600	SH		DFND	2	6,600	0	0
IMMUNOCORE HLDGS PLC	ADS	45258D105	62,767,510	965,654	SH		DFND	1,2	965,654	0	0
INCYTE CORP	COM	45337C102	193,014	3,388	SH		DFND	2	3,388	0	0
INCYTE CORP	COM	45337C102	122,485,500	2,150,000	SH		DFND	1,2	2,150,000	0	0
INSMED INC	COM PAR $.01	457669307	545,313	20,100	SH		DFND	2	20,100	0	0
INSMED INC	COM PAR $.01	457669307	57,562,888	2,121,743	SH		DFND	3	2,121,743	0	0
INSPIRE MED SYS INC	COM	457730109	18,108,515	84,308	SH		DFND	2	84,308	0	0
INSPIRE MED SYS INC	COM	457730109	28,649,979	133,386	SH		DFND	3	133,386	0	0
INSULET CORP	COM	45784P101	50,362,119	293,828	SH		DFND	2	293,828	0	0
INTRA-CELLULAR THERAPIES INC	COM	46116X101	1,348,154	19,482	SH		DFND	2	19,482	0	0
INTRA-CELLULAR THERAPIES INC	COM	46116X101	193,760,000	2,800,000	SH		DFND	1,2	2,800,000	0	0
INTUITIVE SURGICAL INC	COM NEW	46120E602	244,021,186	611,444	SH		DFND	2	611,444	0	0
INTUITIVE SURGICAL INC	COM NEW	46120E602	28,232,425	70,742	SH		DFND	3	70,742	0	0
IONIS PHARMACEUTICALS INC	COM	462222100	1,712,932	39,514	SH		DFND	2	39,514	0	0
IONIS PHARMACEUTICALS INC	COM	462222100	358,071,000	8,260,000	SH		DFND	1,2	8,260,000	0	0
IONQ INC	COM	46222L108	11,059	1,107	SH		DFND	2	1,107	0	0
IQVIA HLDGS INC	COM	46266C105	2,108,091	8,336	SH		DFND	2	8,336	0	0
JOHNSON & JOHNSON	COM	478160104	1,015,580	6,420	SH		DFND	2	6,420	0	0
KRYSTAL BIOTECH INC	COM	501147102	855,843	4,810	SH		DFND	2	4,810	0	0
LABORATORY CORP AMER HLDGS	COM NEW	50540R409	32,332	148	SH		DFND	2	148	0	0
LEGEND BIOTECH CORP	SPONSORED ADS	52490G102	16,449,514	293,270	SH		DFND	2	293,270	0	0
MACROGENICS INC	COM	556099109	528,433	35,899	SH		DFND	2	35,899	0	0
MACROGENICS INC	COM	556099109	146,169,055	9,929,963	SH		DFND	1,2	9,929,963	0	0
MADRIGAL PHARMACEUTICALS INC	COM	558868105	283,062	1,060	SH		DFND	2	1,060	0	0
MCKESSON CORP	COM	58155Q103	4,830,039	8,997	SH		DFND	2	8,997	0	0
MEDTRONIC PLC	SHS	G5960L103	87,760,050	1,007,000	SH		DFND	2	1,007,000	0	0
MERCK & CO INC	COM	58933Y105	41,016,789	310,851	SH		DFND	2	310,851	0	0
MERUS N V	COM	N5749R100	441,294	9,800	SH		DFND	2	9,800	0	0
METTLER TOLEDO INTERNATIONAL	COM	592688105	43,933	33	SH		DFND	2	33	0	0
MICROSOFT CORP	COM	594918104	75,730	180	SH		DFND	2	180	0	0
MINERALYS THERAPEUTICS INC	COM	603170101	118,772	9,200	SH		DFND	2	9,200	0	0
MODERNA INC	COM	60770K107	1,181,644	11,089	SH		DFND	2	11,089	0	0
MODERNA INC	COM	60770K107	181,152,000	1,700,000	SH		DFND	1,2	1,700,000	0	0
MOLECULAR TEMPLATES INC	COM NEW	608550208	2,306,797	1,029,820	SH		DFND	1,2	1,029,820	0	0
MOLINA HEALTHCARE INC	COM	60855R100	41,034,933	99,883	SH		DFND	2	99,883	0	0
MOONLAKE IMMUNOTHERAPEUTICS	CLASS A ORD	61559X104	221,012	4,400	SH		DFND	2	4,400	0	0
NATERA INC	COM	632307104	24,678,835	269,832	SH		DFND	2	269,832	0	0
NEOGENOMICS INC	COM NEW	64049M209	14,871,513	946,025	SH		DFND	3	946,025	0	0
NEUROCRINE BIOSCIENCES INC	COM	64125C109	2,189,342	15,874	SH		DFND	2	15,874	0	0
NEUROCRINE BIOSCIENCES INC	COM	64125C109	281,356,800	2,040,000	SH		DFND	1,2	2,040,000	0	0
NEVRO CORP	COM	64157F103	1,952,793	135,235	SH		DFND	2	135,235	0	0
NVIDIA CORPORATION	COM	67066G104	87,645	97	SH		DFND	2	97	0	0
OMNIAB INC	COM	68218J103	62,092	11,456	SH		DFND	2	11,456	0	0
OMNICELL COM	COM	68213N109	6,879,924	235,372	SH		DFND	2	235,372	0	0
OPTION CARE HEALTH INC	COM NEW	68404L201	62,628,001	1,867,263	SH		DFND	3	1,867,263	0	0
ORACLE CORP	COM	68389X105	85,038	677	SH		DFND	2	677	0	0
OUTSET MED INC	COM	690145107	1,270,637	572,359	SH		DFND	2	572,359	0	0
PACIFIC BIOSCIENCES CALIF IN	COM	69404D108	7,101,694	1,893,785	SH		DFND	2	1,893,785	0	0
PACIFIC BIOSCIENCES CALIF IN	COM	69404D108	10,119,248	2,698,466	SH		DFND	3	2,698,466	0	0
PENUMBRA INC	COM	70975L107	40,430,842	181,158	SH		DFND	2	181,158	0	0
PFIZER INC	COM	717081103	938,894	33,834	SH		DFND	2	33,834	0	0
PHREESIA INC	COM	71944F106	10,609,150	443,341	SH		DFND	2	443,341	0	0
PRIVIA HEALTH GROUP INC	COM	74276R102	20,749,160	1,059,171	SH		DFND	2	1,059,171	0	0
PROCEPT BIOROBOTICS CORP	COM	74276L105	43,989,434	890,114	SH		DFND	2	890,114	0	0
PROTAGONIST THERAPEUTICS INC	COM	74366E102	553,894	19,146	SH		DFND	2	19,146	0	0
QUALCOMM INC	COM	747525103	87,528	517	SH		DFND	2	517	0	0
RECURSION PHARMACEUTICALS IN	CL A	75629V104	4,239,733	425,249	SH		DFND	2	425,249	0	0
REGENERON PHARMACEUTICALS	COM	75886F107	6,811,542	7,077	SH		DFND	2	7,077	0	0
REGENXBIO INC	COM	75901B107	252,840	12,000	SH		DFND	2	12,000	0	0
RELAY THERAPEUTICS INC	COM	75943R102	13,429	1,618	SH		DFND	2	1,618	0	0
RELAY THERAPEUTICS INC	COM	75943R102	49,177,500	5,925,000	SH		DFND	1,2	5,925,000	0	0
RESMED INC	COM	761152107	6,018,330	30,391	SH		DFND	2	30,391	0	0
REVOLUTION MEDICINES INC	COM	76155X100	866,987	26,900	SH		DFND	2	26,900	0	0
REVOLUTION MEDICINES INC	COM	76155X100	162,655,141	5,046,700	SH		DFND	1,2	5,046,700	0	0
RHYTHM PHARMACEUTICALS INC	COM	76243J105	541,625	12,500	SH		DFND	2	12,500	0	0
ROCKET PHARMACEUTICALS INC	COM	77313F106	530,718	19,700	SH		DFND	2	19,700	0	0
SAGE THERAPEUTICS INC	COM	78667J108	90,908	4,851	SH		DFND	2	4,851	0	0
SAGE THERAPEUTICS INC	COM	78667J108	83,593,387	4,460,693	SH		DFND	1,2	4,460,693	0	0
SAREPTA THERAPEUTICS INC	COM	803607100	453,110	3,500	SH		DFND	2	3,500	0	0
SAREPTA THERAPEUTICS INC	COM	803607100	32,108,799	248,021	SH		DFND	3	248,021	0	0
SCHOLAR ROCK HLDG CORP	COM	80706P103	576,809	32,478	SH		DFND	2	32,478	0	0
SCHOLAR ROCK HLDG CORP	COM	80706P103	37,877,196	2,132,725	SH		DFND	1,2	2,132,725	0	0
SHOCKWAVE MED INC	COM	82489T104	34,447,095	105,786	SH		DFND	2	105,786	0	0
SI-BONE INC	COM	825704109	18,661,080	1,139,956	SH		DFND	3	1,139,956	0	0
SILK RD MED INC	COM	82710M100	27,813,974	1,518,230	SH		DFND	3	1,518,230	0	0
SIMPLY GOOD FOODS CO	COM	82900L102	268,837	7,900	SH		DFND	2	7,900	0	0
SPDR S&P 500 ETF TR	TR UNIT	78462F103	3,483,646	6,660	SH		DFND	2	6,660	0	0
STERIS PLC	SHS USD	G8473T100	16,509,432	73,434	SH		DFND	2	73,434	0	0
STRUCTURE THERAPEUTICS INC	SPONSORED ADS	86366E106	325,736	7,600	SH		DFND	2	7,600	0	0
STRUCTURE THERAPEUTICS INC	SPONSORED ADS	86366E106	15,272,132	356,326	SH		DFND	3	356,326	0	0
STRYKER CORPORATION	COM	863667101	160,805,306	449,340	SH		DFND	2	449,340	0	0
TANDEM DIABETES CARE INC	COM NEW	875372203	71,949,154	2,031,888	SH		DFND	3	2,031,888	0	0
TELADOC HEALTH INC	COM	87918A105	4,119,250	272,798	SH		DFND	2	272,798	0	0
TENET HEALTHCARE CORP	COM NEW	88033G407	446,087	4,244	SH		DFND	2	4,244	0	0
TEVA PHARMACEUTICAL INDS LTD	SPONSORED ADS	881624209	2,006,625	142,213	SH		DFND	2	142,213	0	0
THE CIGNA GROUP	COM	125523100	28,926,268	79,645	SH		DFND	2	79,645	0	0
THERMO FISHER SCIENTIFIC INC	COM	883556102	23,222,827	39,956	SH		DFND	2	39,956	0	0
TRANSMEDICS GROUP INC	COM	89377M109	26,918,892	364,064	SH		DFND	2	364,064	0	0
UNITEDHEALTH GROUP INC	COM	91324P102	46,689,786	94,380	SH		DFND	2	94,380	0	0
UNITEDHEALTH GROUP INC	COM	91324P102	26,881,503	54,339	SH		DFND	3	54,339	0	0
VANECK ETF TRUST	GOLD MINERS ETF	92189F106	1,043,460	33,000	SH		DFND	2	33,000	0	0
VAXCYTE INC	COM	92243G108	904,698	13,244	SH		DFND	2	13,244	0	0
VEEVA SYS INC	CL A COM	922475108	38,981,147	168,247	SH		DFND	2	168,247	0	0
VERONA PHARMA PLC	SPONSORED ADS	925050106	201,125	12,500	SH		DFND	2	12,500	0	0
VERONA PHARMA PLC	SPONSORED ADS	925050106	18,130,132	1,126,795	SH		DFND	3	1,126,795	0	0
VERTEX PHARMACEUTICALS INC	COM	92532F100	37,098,388	88,750	SH		DFND	2	88,750	0	0
VERTEX PHARMACEUTICALS INC	COM	92532F100	242,445,800	580,000	SH		DFND	1,2	580,000	0	0
VERVE THERAPEUTICS INC	COM	92539P101	387,776	29,200	SH		DFND	2	29,200	0	0
VIATRIS INC	COM	92556V106	173,309	14,515	SH		DFND	2	14,515	0	0
VIKING THERAPEUTICS INC	COM	92686J106	442,800	5,400	SH		DFND	2	5,400	0	0
VIRIDIAN THERAPEUTICS INC	COM	92790C104	334,441	19,100	SH		DFND	2	19,100	0	0
WAVE LIFE SCIENCES LTD	SHS	Y95308105	25,262,806	4,094,458	SH		DFND	1,2	4,094,458	0	0
WEST PHARMACEUTICAL SVSC INC	COM	955306105	344,268	870	SH		DFND	2	870	0	0
XENON PHARMACEUTICALS INC	COM	98420N105	607,005	14,100	SH		DFND	2	14,100	0	0
ZIMMER BIOMET HOLDINGS INC	COM	98956P102	37,247,000	282,217	SH		DFND	2	282,217	0	0
ZOETIS INC	CL A	98978V103	1,270,767	7,510	SH		DFND	2	7,510	0	0