COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 |
| | | VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY |
NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
10X GENOMICS INC | CL A COM | 88025U109 | 6,364,873 | 281,881 | SH | | DFND | 2 | 281,881 | 0 | 0 |
ABBOTT LABS | COM | 002824100 | 174,884,841 | 1,533,943 | SH | | DFND | 2 | 1,533,943 | 0 | 0 |
ABBOTT LABS | COM | 002824100 | 23,941,530 | 209,995 | SH | | DFND | 3 | 209,995 | 0 | 0 |
ABBVIE INC | COM | 00287Y109 | 8,469,127 | 42,886 | SH | | DFND | 2 | 42,886 | 0 | 0 |
ACCOLADE INC | COM | 00437E102 | 2,467,330 | 640,865 | SH | | DFND | 2 | 640,865 | 0 | 0 |
ADMA BIOLOGICS INC | COM | 000899104 | 517,741 | 25,900 | SH | | DFND | 2 | 25,900 | 0 | 0 |
AGILENT TECHNOLOGIES INC | COM | 00846U101 | 114,181 | 769 | SH | | DFND | 2 | 769 | 0 | 0 |
AGIOS PHARMACEUTICALS INC | COM | 00847X104 | 165,986,703 | 3,735,915 | SH | | DFND | 1,2 | 3,735,915 | 0 | 0 |
ALIGN TECHNOLOGY INC | COM | 016255101 | 36,621,063 | 143,996 | SH | | DFND | 2 | 143,996 | 0 | 0 |
ALNYLAM PHARMACEUTICALS INC | COM | 02043Q107 | 2,501,398 | 9,095 | SH | | DFND | 2 | 9,095 | 0 | 0 |
ALNYLAM PHARMACEUTICALS INC | COM | 02043Q107 | 220,024,000 | 800,000 | SH | | DFND | 1,2 | 800,000 | 0 | 0 |
ALPHABET INC | CAP STK CL C | 02079K107 | 1,003,140 | 6,000 | SH | | DFND | 2 | 6,000 | 0 | 0 |
ALTIMMUNE INC | COM NEW | 02155H200 | 5,302,872 | 863,660 | SH | | DFND | 3 | 863,660 | 0 | 0 |
AMGEN INC | COM | 031162100 | 8,104,226 | 25,152 | SH | | DFND | 2 | 25,152 | 0 | 0 |
AMNEAL PHARMACEUTICALS INC | COM STK CL A | 03168L105 | 635,764 | 76,414 | SH | | DFND | 2 | 76,414 | 0 | 0 |
ANNEXON INC | COM | 03589W102 | 30,531,157 | 5,157,290 | SH | | DFND | 1,2 | 5,157,290 | 0 | 0 |
APELLIS PHARMACEUTICALS INC | COM | 03753U106 | 549,287 | 19,046 | SH | | DFND | 2 | 19,046 | 0 | 0 |
ARCELLX INC | COMMON STOCK | 03940C100 | 334,040 | 4,000 | SH | | DFND | 2 | 4,000 | 0 | 0 |
ARCUTIS BIOTHERAPEUTICS INC | COM | 03969K108 | 367,350 | 39,500 | SH | | DFND | 2 | 39,500 | 0 | 0 |
ARGENX SE | SPONSORED ADR | 04016X101 | 1,533,544 | 2,829 | SH | | DFND | 2 | 2,829 | 0 | 0 |
ARGENX SE | SPONSORED ADR | 04016X101 | 341,510,400 | 630,000 | SH | | DFND | 1,2 | 630,000 | 0 | 0 |
ARVINAS INC | COM | 04335A105 | 162,558 | 6,600 | SH | | DFND | 2 | 6,600 | 0 | 0 |
ARVINAS INC | COM | 04335A105 | 58,619,400 | 2,380,000 | SH | | DFND | 1,2 | 2,380,000 | 0 | 0 |
ASTRANA HEALTH INC | COM NEW | 03763A207 | 14,727,305 | 254,182 | SH | | DFND | 3 | 254,182 | 0 | 0 |
ASTRAZENECA PLC | SPONSORED ADR | 046353108 | 2,609,985 | 33,500 | SH | | DFND | 2 | 33,500 | 0 | 0 |
AUTOLUS THERAPEUTICS PLC | SPON ADS | 05280R100 | 150,645 | 41,500 | SH | | DFND | 2 | 41,500 | 0 | 0 |
AXSOME THERAPEUTICS INC | COM | 05464T104 | 341,506 | 3,800 | SH | | DFND | 2 | 3,800 | 0 | 0 |
AXSOME THERAPEUTICS INC | COM | 05464T104 | 32,657,050 | 363,381 | SH | | DFND | 3 | 363,381 | 0 | 0 |
BAIDU INC | SPON ADR REP A | 056752108 | 210,580 | 2,000 | SH | | DFND | 2 | 2,000 | 0 | 0 |
BEAM THERAPEUTICS INC | COM | 07373V105 | 37,193,965 | 1,518,121 | SH | | DFND | 1,2 | 1,518,121 | 0 | 0 |
BECTON DICKINSON & CO | COM | 075887109 | 81,403,316 | 337,633 | SH | | DFND | 2 | 337,633 | 0 | 0 |
BEIGENE LTD | SPONSORED ADR | 07725L102 | 13,185,248 | 58,729 | SH | | DFND | 2 | 58,729 | 0 | 0 |
BIO RAD LABS INC | CL A | 090572207 | 15,441,202 | 46,151 | SH | | DFND | 3 | 46,151 | 0 | 0 |
BIOGEN INC | COM | 09062X103 | 510,575 | 2,634 | SH | | DFND | 2 | 2,634 | 0 | 0 |
BIOHAVEN LTD | COM | G1110E107 | 101,981,424 | 2,040,853 | SH | | DFND | 1,2 | 2,040,853 | 0 | 0 |
BIOMARIN PHARMACEUTICAL INC | COM | 09061G101 | 3,266,447 | 46,471 | SH | | DFND | 2 | 46,471 | 0 | 0 |
BIOMARIN PHARMACEUTICAL INC | COM | 09061G101 | 19,997,856 | 284,505 | SH | | DFND | 3 | 284,505 | 0 | 0 |
BIONTECH SE | SPONSORED ADS | 09075V102 | 1,035,793 | 8,721 | SH | | DFND | 2 | 8,721 | 0 | 0 |
BLACK DIAMOND THERAPEUTICS I | COM | 09203E105 | 37,052,600 | 8,517,839 | SH | | DFND | 1,2 | 8,517,839 | 0 | 0 |
BLUEPRINT MEDICINES CORP | COM | 09627Y109 | 296,000 | 3,200 | SH | | DFND | 2 | 3,200 | 0 | 0 |
BOSTON SCIENTIFIC CORP | COM | 101137107 | 205,544,389 | 2,452,797 | SH | | DFND | 2 | 2,452,797 | 0 | 0 |
BRIDGEBIO PHARMA INC | COM | 10806X102 | 264,784 | 10,400 | SH | | DFND | 2 | 10,400 | 0 | 0 |
BRISTOL-MYERS SQUIBB CO | COM | 110122108 | 1,905,326 | 36,825 | SH | | DFND | 2 | 36,825 | 0 | 0 |
CARDINAL HEALTH INC | COM | 14149Y108 | 3,340,356 | 30,224 | SH | | DFND | 2 | 30,224 | 0 | 0 |
CAREDX INC | COM | 14167L103 | 516,555 | 16,543 | SH | | DFND | 2 | 16,543 | 0 | 0 |
CAREDX INC | COM | 14167L103 | 97,700,308 | 3,128,913 | SH | | DFND | 3 | 3,128,913 | 0 | 0 |
CASTLE BIOSCIENCES INC | COM | 14843C105 | 35,993,096 | 1,262,030 | SH | | DFND | 3 | 1,262,030 | 0 | 0 |
CELLDEX THERAPEUTICS INC NEW | COM NEW | 15117B202 | 104,404,194 | 3,071,615 | SH | | DFND | 1,2 | 3,071,615 | 0 | 0 |
CENCORA INC | COM | 03073E105 | 16,217,689 | 72,053 | SH | | DFND | 2 | 72,053 | 0 | 0 |
CENTENE CORP DEL | COM | 15135B101 | 6,527,378 | 86,708 | SH | | DFND | 2 | 86,708 | 0 | 0 |
CERTARA INC | COM | 15687V109 | 1,123,270 | 95,924 | SH | | DFND | 2 | 95,924 | 0 | 0 |
CHARLES RIV LABS INTL INC | COM | 159864107 | 14,401,462 | 73,115 | SH | | DFND | 3 | 73,115 | 0 | 0 |
COOPER COS INC | COM | 216648501 | 43,846,137 | 397,373 | SH | | DFND | 2 | 397,373 | 0 | 0 |
CRISPR THERAPEUTICS AG | NAMEN AKT | H17182108 | 28,657,800 | 610,000 | SH | | DFND | 1,2 | 610,000 | 0 | 0 |
CVS HEALTH CORP | COM | 126650100 | 1,387,510 | 22,066 | SH | | DFND | 2 | 22,066 | 0 | 0 |
CYTOKINETICS INC | COM NEW | 23282W605 | 577,685 | 10,941 | SH | | DFND | 2 | 10,941 | 0 | 0 |
DANAHER CORPORATION | COM | 235851102 | 23,270,274 | 83,700 | SH | | DFND | 2 | 83,700 | 0 | 0 |
DANAHER CORPORATION | COM | 235851102 | 6,085,858 | 21,890 | SH | | DFND | 3 | 21,890 | 0 | 0 |
DENALI THERAPEUTICS INC | COM | 24823R105 | 457,341 | 15,700 | SH | | DFND | 2 | 15,700 | 0 | 0 |
DEXCOM INC | COM | 252131107 | 53,873,813 | 803,607 | SH | | DFND | 2 | 803,607 | 0 | 0 |
DEXCOM INC | COM | 252131107 | 14,308,414 | 213,431 | SH | | DFND | 3 | 213,431 | 0 | 0 |
DOXIMITY INC | CL A | 26622P107 | 1,266,144 | 29,060 | SH | | DFND | 2 | 29,060 | 0 | 0 |
DR REDDYS LABS LTD | ADR | 256135203 | 1,636,273 | 20,595 | SH | | DFND | 2 | 20,595 | 0 | 0 |
EDGEWISE THERAPEUTICS INC | COM | 28036F105 | 38,138,115 | 1,428,929 | SH | | DFND | 1,2 | 1,428,929 | 0 | 0 |
EDWARDS LIFESCIENCES CORP | COM | 28176E108 | 54,983,594 | 833,211 | SH | | DFND | 2 | 833,211 | 0 | 0 |
EDWARDS LIFESCIENCES CORP | COM | 28176E108 | 19,854,081 | 300,865 | SH | | DFND | 3 | 300,865 | 0 | 0 |
ELEVANCE HEALTH INC | COM | 036752103 | 26,988,520 | 51,901 | SH | | DFND | 2 | 51,901 | 0 | 0 |
ELEVANCE HEALTH INC | COM | 036752103 | 19,462,040 | 37,427 | SH | | DFND | 3 | 37,427 | 0 | 0 |
ELI LILLY & CO | COM | 532457108 | 39,199,301 | 44,246 | SH | | DFND | 2 | 44,246 | 0 | 0 |
ENCOMPASS HEALTH CORP | COM | 29261A100 | 1,858,677 | 19,233 | SH | | DFND | 2 | 19,233 | 0 | 0 |
ESPERION THERAPEUTICS INC NE | COM | 29664W105 | 16,407,706 | 9,944,064 | SH | | DFND | 1,2 | 9,944,064 | 0 | 0 |
ESSA PHARMA INC | COM NEW | 29668H708 | 47,750,273 | 7,879,583 | SH | | DFND | 1,2 | 7,879,583 | 0 | 0 |
EVOLENT HEALTH INC | CL A | 30050B101 | 8,528,089 | 301,559 | SH | | DFND | 2 | 301,559 | 0 | 0 |
EVOLENT HEALTH INC | CL A | 30050B101 | 66,980,925 | 2,368,491 | SH | | DFND | 3 | 2,368,491 | 0 | 0 |
EXACT SCIENCES CORP | COM | 30063P105 | 22,897,244 | 336,131 | SH | | DFND | 2 | 336,131 | 0 | 0 |
EXACT SCIENCES CORP | COM | 30063P105 | 75,840,312 | 1,113,334 | SH | | DFND | 3 | 1,113,334 | 0 | 0 |
EXELIXIS INC | COM | 30161Q104 | 41,520,000 | 1,600,000 | SH | | DFND | 1,2 | 1,600,000 | 0 | 0 |
FATE THERAPEUTICS INC | COM | 31189P102 | 16,939,227 | 4,839,779 | SH | | DFND | 1,2 | 4,839,779 | 0 | 0 |
GARMIN LTD | SHS | H2906T109 | 184,832 | 1,050 | SH | | DFND | 2 | 1,050 | 0 | 0 |
GE HEALTHCARE TECHNOLOGIES I | COMMON STOCK | 36266G107 | 49,925,103 | 531,967 | SH | | DFND | 2 | 531,967 | 0 | 0 |
GENERATION BIO CO | COM | 37148K100 | 9,679,574 | 3,918,856 | SH | | DFND | 1,2 | 3,918,856 | 0 | 0 |
GILEAD SCIENCES INC | COM | 375558103 | 3,858,904 | 46,027 | SH | | DFND | 2 | 46,027 | 0 | 0 |
GLAUKOS CORP | COM | 377322102 | 8,205,425 | 62,983 | SH | | DFND | 2 | 62,983 | 0 | 0 |
GLOBUS MED INC | CL A | 379577208 | 33,609,349 | 469,798 | SH | | DFND | 2 | 469,798 | 0 | 0 |
HCA HEALTHCARE INC | COM | 40412C101 | 46,546,396 | 114,525 | SH | | DFND | 2 | 114,525 | 0 | 0 |
HOLOGIC INC | COM | 436440101 | 20,191,001 | 247,864 | SH | | DFND | 2 | 247,864 | 0 | 0 |
HUMANA INC | COM | 444859102 | 9,008,086 | 28,440 | SH | | DFND | 2 | 28,440 | 0 | 0 |
HUTCHMED CHINA LTD | SPONSORED ADS | 44842L103 | 469,013 | 24,015 | SH | | DFND | 2 | 24,015 | 0 | 0 |
IDEAYA BIOSCIENCES INC | COM | 45166A102 | 228,096 | 7,200 | SH | | DFND | 2 | 7,200 | 0 | 0 |
IDEXX LABS INC | COM | 45168D104 | 46,115,976 | 91,279 | SH | | DFND | 2 | 91,279 | 0 | 0 |
ILLUMINA INC | COM | 452327109 | 5,894,010 | 45,196 | SH | | DFND | 2 | 45,196 | 0 | 0 |
IMMUNOCORE HLDGS PLC | ADS | 45258D105 | 37,526,094 | 1,205,464 | SH | | DFND | 1,2 | 1,205,464 | 0 | 0 |
INCYTE CORP | COM | 45337C102 | 36,421 | 551 | SH | | DFND | 2 | 551 | 0 | 0 |
INCYTE CORP | COM | 45337C102 | 142,115,000 | 2,150,000 | SH | | DFND | 1,2 | 2,150,000 | 0 | 0 |
INSMED INC | COM PAR $.01 | 457669307 | 569,400 | 7,800 | SH | | DFND | 2 | 7,800 | 0 | 0 |
INSMED INC | COM PAR $.01 | 457669307 | 37,787,282 | 517,634 | SH | | DFND | 3 | 517,634 | 0 | 0 |
INSPIRE MED SYS INC | COM | 457730109 | 6,003,106 | 28,444 | SH | | DFND | 2 | 28,444 | 0 | 0 |
INSPIRE MED SYS INC | COM | 457730109 | 35,168,528 | 166,636 | SH | | DFND | 3 | 166,636 | 0 | 0 |
INSULET CORP | COM | 45784P101 | 98,099,237 | 421,479 | SH | | DFND | 2 | 421,479 | 0 | 0 |
INTRA-CELLULAR THERAPIES INC | COM | 46116X101 | 1,143,428 | 15,627 | SH | | DFND | 2 | 15,627 | 0 | 0 |
INTRA-CELLULAR THERAPIES INC | COM | 46116X101 | 180,729,900 | 2,470,000 | SH | | DFND | 1,2 | 2,470,000 | 0 | 0 |
INTUITIVE SURGICAL INC | COM NEW | 46120E602 | 217,091,230 | 441,898 | SH | | DFND | 2 | 441,898 | 0 | 0 |
INTUITIVE SURGICAL INC | COM NEW | 46120E602 | 26,959,424 | 54,877 | SH | | DFND | 3 | 54,877 | 0 | 0 |
IONIS PHARMACEUTICALS INC | COM | 462222100 | 977,464 | 24,400 | SH | | DFND | 2 | 24,400 | 0 | 0 |
IONIS PHARMACEUTICALS INC | COM | 462222100 | 314,471,000 | 7,850,000 | SH | | DFND | 1,2 | 7,850,000 | 0 | 0 |
IQVIA HLDGS INC | COM | 46266C105 | 20,326,339 | 85,776 | SH | | DFND | 2 | 85,776 | 0 | 0 |
IQVIA HLDGS INC | COM | 46266C105 | 10,438,765 | 44,051 | SH | | DFND | 3 | 44,051 | 0 | 0 |
JOHNSON & JOHNSON | COM | 478160104 | 8,304,279 | 51,242 | SH | | DFND | 2 | 51,242 | 0 | 0 |
KRYSTAL BIOTECH INC | COM | 501147102 | 869,921 | 4,779 | SH | | DFND | 2 | 4,779 | 0 | 0 |
KURA ONCOLOGY INC | COM | 50127T109 | 265,744 | 13,600 | SH | | DFND | 2 | 13,600 | 0 | 0 |
LABCORP HOLDINGS INC | COM SHS | 504922105 | 46,037 | 206 | SH | | DFND | 2 | 206 | 0 | 0 |
LEGEND BIOTECH CORP | SPONSORED ADS | 52490G102 | 8,241,900 | 169,134 | SH | | DFND | 2 | 169,134 | 0 | 0 |
MACROGENICS INC | COM | 556099109 | 32,669,578 | 9,929,963 | SH | | DFND | 1,2 | 9,929,963 | 0 | 0 |
MADRIGAL PHARMACEUTICALS INC | COM | 558868105 | 233,442 | 1,100 | SH | | DFND | 2 | 1,100 | 0 | 0 |
MCKESSON CORP | COM | 58155Q103 | 17,671,560 | 35,742 | SH | | DFND | 2 | 35,742 | 0 | 0 |
MEDTRONIC PLC | SHS | G5960L103 | 90,807,229 | 1,008,633 | SH | | DFND | 2 | 1,008,633 | 0 | 0 |
MERCK & CO INC | COM | 58933Y105 | 4,795,979 | 42,233 | SH | | DFND | 2 | 42,233 | 0 | 0 |
MERUS N V | COM | N5749R100 | 399,680 | 8,000 | SH | | DFND | 2 | 8,000 | 0 | 0 |
METTLER TOLEDO INTERNATIONAL | COM | 592688105 | 61,488 | 41 | SH | | DFND | 2 | 41 | 0 | 0 |
MICROSOFT CORP | COM | 594918104 | 83,478 | 194 | SH | | DFND | 2 | 194 | 0 | 0 |
MINERALYS THERAPEUTICS INC | COM | 603170101 | 199,803 | 16,499 | SH | | DFND | 2 | 16,499 | 0 | 0 |
MODERNA INC | COM | 60770K107 | 55,870 | 836 | SH | | DFND | 2 | 836 | 0 | 0 |
MODERNA INC | COM | 60770K107 | 106,928,000 | 1,600,000 | SH | | DFND | 1,2 | 1,600,000 | 0 | 0 |
MOLECULAR TEMPLATES INC | COM NEW | 608550208 | 1,798,147 | 1,279,820 | SH | | DFND | 1,2 | 1,279,820 | 0 | 0 |
MOLINA HEALTHCARE INC | COM | 60855R100 | 23,279,163 | 67,562 | SH | | DFND | 2 | 67,562 | 0 | 0 |
MOONLAKE IMMUNOTHERAPEUTICS | CLASS A ORD | 61559X104 | 221,848 | 4,400 | SH | | DFND | 2 | 4,400 | 0 | 0 |
NATERA INC | COM | 632307104 | 17,577,370 | 138,459 | SH | | DFND | 2 | 138,459 | 0 | 0 |
NEOGENOMICS INC | COM NEW | 64049M209 | 23,786,027 | 1,612,612 | SH | | DFND | 3 | 1,612,612 | 0 | 0 |
NEUROCRINE BIOSCIENCES INC | COM | 64125C109 | 437,836 | 3,800 | SH | | DFND | 2 | 3,800 | 0 | 0 |
NEUROCRINE BIOSCIENCES INC | COM | 64125C109 | 214,309,200 | 1,860,000 | SH | | DFND | 1,2 | 1,860,000 | 0 | 0 |
NEWAMSTERDAM PHARMA COMPANY | ORDINARY SHARES | N62509109 | 127,820 | 7,700 | SH | | DFND | 2 | 7,700 | 0 | 0 |
NIKE INC | CL B | 654106103 | 309,400 | 3,500 | SH | | DFND | 2 | 3,500 | 0 | 0 |
NURIX THERAPEUTICS INC | COM | 67080M103 | 179,760 | 8,000 | SH | | DFND | 2 | 8,000 | 0 | 0 |
NVIDIA CORPORATION | COM | 67066G104 | 86,951 | 716 | SH | | DFND | 2 | 716 | 0 | 0 |
OMNIAB INC | COM | 68218J103 | 48,459 | 11,456 | SH | | DFND | 2 | 11,456 | 0 | 0 |
OMNICELL COM | COM | 68213N109 | 8,620,330 | 197,714 | SH | | DFND | 2 | 197,714 | 0 | 0 |
OPTION CARE HEALTH INC | COM NEW | 68404L201 | 51,797,681 | 1,654,878 | SH | | DFND | 3 | 1,654,878 | 0 | 0 |
ORACLE CORP | COM | 68389X105 | 106,330 | 624 | SH | | DFND | 2 | 624 | 0 | 0 |
PENUMBRA INC | COM | 70975L107 | 52,985,034 | 272,683 | SH | | DFND | 2 | 272,683 | 0 | 0 |
PFIZER INC | COM | 717081103 | 4,082,711 | 141,075 | SH | | DFND | 2 | 141,075 | 0 | 0 |
PHREESIA INC | COM | 71944F106 | 9,626,633 | 422,406 | SH | | DFND | 2 | 422,406 | 0 | 0 |
PRIVIA HEALTH GROUP INC | COM | 74276R102 | 19,287,504 | 1,059,171 | SH | | DFND | 2 | 1,059,171 | 0 | 0 |
PROCEPT BIOROBOTICS CORP | COM | 74276L105 | 49,088,803 | 612,691 | SH | | DFND | 2 | 612,691 | 0 | 0 |
PROTAGONIST THERAPEUTICS INC | COM | 74366E102 | 555,570 | 12,346 | SH | | DFND | 2 | 12,346 | 0 | 0 |
QUALCOMM INC | COM | 747525103 | 72,611 | 427 | SH | | DFND | 2 | 427 | 0 | 0 |
RECURSION PHARMACEUTICALS IN | CL A | 75629V104 | 2,589,086 | 392,881 | SH | | DFND | 2 | 392,881 | 0 | 0 |
REGENERON PHARMACEUTICALS | COM | 75886F107 | 28,148,002 | 26,776 | SH | | DFND | 2 | 26,776 | 0 | 0 |
RELAY THERAPEUTICS INC | COM | 75943R102 | 15,463 | 2,184 | SH | | DFND | 2 | 2,184 | 0 | 0 |
RELAY THERAPEUTICS INC | COM | 75943R102 | 52,215,000 | 7,375,000 | SH | | DFND | 1,2 | 7,375,000 | 0 | 0 |
RESMED INC | COM | 761152107 | 39,090,447 | 160,128 | SH | | DFND | 2 | 160,128 | 0 | 0 |
REVOLUTION MEDICINES INC | COM | 76155X100 | 571,410 | 12,600 | SH | | DFND | 2 | 12,600 | 0 | 0 |
REVOLUTION MEDICINES INC | COM | 76155X100 | 220,344,766 | 4,858,760 | SH | | DFND | 1,2 | 4,858,760 | 0 | 0 |
RHYTHM PHARMACEUTICALS INC | COM | 76243J105 | 822,523 | 15,700 | SH | | DFND | 2 | 15,700 | 0 | 0 |
ROCKET PHARMACEUTICALS INC | COM | 77313F106 | 171,771 | 9,300 | SH | | DFND | 2 | 9,300 | 0 | 0 |
SAGE THERAPEUTICS INC | COM | 78667J108 | 32,206,203 | 4,460,693 | SH | | DFND | 1,2 | 4,460,693 | 0 | 0 |
SANOFI | SPONSORED ADR | 80105N105 | 870,732 | 15,109 | SH | | DFND | 2 | 15,109 | 0 | 0 |
SAREPTA THERAPEUTICS INC | COM | 803607100 | 287,247 | 2,300 | SH | | DFND | 2 | 2,300 | 0 | 0 |
SAREPTA THERAPEUTICS INC | COM | 803607100 | 42,718,375 | 342,048 | SH | | DFND | 3 | 342,048 | 0 | 0 |
SCHOLAR ROCK HLDG CORP | COM | 80706P103 | 228,109 | 28,478 | SH | | DFND | 2 | 28,478 | 0 | 0 |
SCHOLAR ROCK HLDG CORP | COM | 80706P103 | 17,083,127 | 2,132,725 | SH | | DFND | 1,2 | 2,132,725 | 0 | 0 |
SI-BONE INC | COM | 825704109 | 20,188,644 | 1,444,109 | SH | | DFND | 3 | 1,444,109 | 0 | 0 |
STERIS PLC | SHS USD | G8473T100 | 22,139,536 | 91,282 | SH | | DFND | 2 | 91,282 | 0 | 0 |
STRUCTURE THERAPEUTICS INC | SPONSORD ADS | 86366E106 | 852,475 | 19,423 | SH | | DFND | 2 | 19,423 | 0 | 0 |
STRUCTURE THERAPEUTICS INC | SPONSORD ADS | 86366E106 | 26,787,603 | 610,335 | SH | | DFND | 3 | 610,335 | 0 | 0 |
STRYKER CORPORATION | COM | 863667101 | 190,242,045 | 526,607 | SH | | DFND | 2 | 526,607 | 0 | 0 |
SUMMIT THERAPEUTICS INC | COM | 86627T108 | 1,403,659 | 64,094 | SH | | DFND | 2 | 64,094 | 0 | 0 |
SUMMIT THERAPEUTICS INC | CALL | 86627T908 | 219,000 | 10,000 | SH | Call | DFND | 2 | 100 | 0 | 0 |
TANDEM DIABETES CARE INC | COM NEW | 875372203 | 93,302 | 2,200 | SH | | DFND | 2 | 2,200 | 0 | 0 |
TANDEM DIABETES CARE INC | COM NEW | 875372203 | 78,402,985 | 1,848,691 | SH | | DFND | 3 | 1,848,691 | 0 | 0 |
TEMPUS AI INC | CL A | 88023B103 | 29,206 | 516 | SH | | DFND | 2 | 516 | 0 | 0 |
TENET HEALTHCARE CORP | COM NEW | 88033G407 | 934,875 | 5,625 | SH | | DFND | 2 | 5,625 | 0 | 0 |
TERNS PHARMACEUTICALS INC | COM | 880881107 | 200,160 | 24,000 | SH | | DFND | 2 | 24,000 | 0 | 0 |
TERNS PHARMACEUTICALS INC | COM | 880881107 | 8,491,246 | 1,018,135 | SH | | DFND | 3 | 1,018,135 | 0 | 0 |
TEVA PHARMACEUTICAL INDS LTD | SPONSORED ADS | 881624209 | 1,276,194 | 70,821 | SH | | DFND | 2 | 70,821 | 0 | 0 |
THE CIGNA GROUP | COM | 125523100 | 41,020,921 | 118,407 | SH | | DFND | 2 | 118,407 | 0 | 0 |
THERMO FISHER SCIENTIFIC INC | COM | 883556102 | 26,630,676 | 43,052 | SH | | DFND | 2 | 43,052 | 0 | 0 |
THERMO FISHER SCIENTIFIC INC | COM | 883556102 | 6,538,903 | 10,571 | SH | | DFND | 3 | 10,571 | 0 | 0 |
TRANSMEDICS GROUP INC | COM | 89377M109 | 26,665,508 | 169,844 | SH | | DFND | 2 | 169,844 | 0 | 0 |
TRAVERE THERAPEUTICS INC | COM | 89422G107 | 433,690 | 31,000 | SH | | DFND | 2 | 31,000 | 0 | 0 |
ULTRAGENYX PHARMACEUTICAL IN | COM | 90400D108 | 222,200 | 4,000 | SH | | DFND | 2 | 4,000 | 0 | 0 |
UNITEDHEALTH GROUP INC | COM | 91324P102 | 70,809,425 | 121,108 | SH | | DFND | 2 | 121,108 | 0 | 0 |
UNITEDHEALTH GROUP INC | COM | 91324P102 | 61,065,149 | 104,442 | SH | | DFND | 3 | 104,442 | 0 | 0 |
VAXCYTE INC | COM | 92243G108 | 1,369,069 | 11,981 | SH | | DFND | 2 | 11,981 | 0 | 0 |
VEEVA SYS INC | CL A COM | 922475108 | 34,316,263 | 163,512 | SH | | DFND | 2 | 163,512 | 0 | 0 |
VERACYTE INC | COM | 92337F107 | 122,544 | 3,600 | SH | | DFND | 2 | 3,600 | 0 | 0 |
VERONA PHARMA PLC | SPONSORED ADS | 925050106 | 457,443 | 15,900 | SH | | DFND | 2 | 15,900 | 0 | 0 |
VERONA PHARMA PLC | SPONSORED ADS | 925050106 | 34,643,654 | 1,204,159 | SH | | DFND | 3 | 1,204,159 | 0 | 0 |
VERTEX PHARMACEUTICALS INC | COM | 92532F100 | 28,558,702 | 61,406 | SH | | DFND | 2 | 61,406 | 0 | 0 |
VERTEX PHARMACEUTICALS INC | COM | 92532F100 | 237,190,800 | 510,000 | SH | | DFND | 1,2 | 510,000 | 0 | 0 |
VIATRIS INC | COM | 92556V106 | 456,076 | 39,283 | SH | | DFND | 2 | 39,283 | 0 | 0 |
VIKING THERAPEUTICS INC | COM | 92686J106 | 1,024,292 | 16,179 | SH | | DFND | 2 | 16,179 | 0 | 0 |
WAVE LIFE SCIENCES LTD | SHS | Y95308105 | 33,574,556 | 4,094,458 | SH | | DFND | 1,2 | 4,094,458 | 0 | 0 |
WAYSTAR HLDG CORP | COM | 946784105 | 4,189,134 | 150,202 | SH | | DFND | 2 | 150,202 | 0 | 0 |
XENON PHARMACEUTICALS INC | COM | 98420N105 | 322,834 | 8,200 | SH | | DFND | 2 | 8,200 | 0 | 0 |
ZIMMER BIOMET HOLDINGS INC | COM | 98956P102 | 46,721,300 | 432,805 | SH | | DFND | 2 | 432,805 | 0 | 0 |
ZOETIS INC | CL A | 98978V103 | 1,032,388 | 5,284 | SH | | DFND | 2 | 5,284 | 0 | 0 |