SENESTECH, INC.
November 14, 2016
VIA EDGAR AND ELECTRONIC MAIL
United States Securities and Exchange Commission (the “Commission”)
Division of Corporation Finance
100 F. Street, N.E.
Mail Stop 3561
Washington, D.C. 20549
| Attn.: | Ms. Anne Nguyen Parker Assistant Director |
| Office of Transportation and Leisure |
Re: SenesTech, Inc. (the “Company”)
Registration Statement on Form S-1, Amendment No. 4
File No. 333-213736
Ladies and Gentlemen:
In accordance with Rule 461 under the Securities Act of 1933, as amended, the undersigned respectfully requests that the effective date for the Registration Statement referred to above be accelerated so that it will be declared effective at 4:30 p.m., Eastern time on Monday, November 14, 2016, or as soon thereafter as is practicable.
The Company hereby acknowledges that:
| · | should the Commission or the staff, acting pursuant to delegated authority, declare the filing effective, it does not foreclose the Commission from taking any action with respect to the filing; |
| · | the action of the Commission or the staff, acting pursuant to delegated authority, in declaring the filing effective, does not relieve the Company from its full responsibility for the adequacy and accuracy of the disclosure in the filing; and |
| · | the Company may not assert staff comments and the declaration of effectiveness as a defense in any proceeding initiated by the Commission or any person under the federal securities laws of the United States. |
| Very truly yours, | ||
| SENESTECH, INC. | ||
| By: | /s/ Loretta P. Mayer Ph.D. | |
| Name: Loretta P. Mayer Ph.D. | ||
| Title: Chief Executive Officer | ||
