ObsEva (OBSVF) 6-K Obseva Announces U.S. FDA Acceptance of New Drug Application for Linzagolix

Exhibit 99.2

Obseva Announces Appointment of Stephanie Brown to its Board of Directors

Ad hoc announcement pursuant to Art. 53 LR of the SIX Swiss Exchange

GENEVA, Switzerland November 22, 2021 – ObsEva SA (NASDAQ: OBSV; SIX: OBSN), a biopharmaceutical company developing and commercializing novel therapies to improve women’s reproductive health, today announced that Stephanie Brown has been selected to join its Board of Directors and will be proposed for election at the 2022 Annual General Meeting. In the meantime, and effective December 1, 2021, she will join the Board of Directors as an Observer. Ms. Brown brings valuable commercial expertise and industry insight to the Company. Jacky Vonderscher, Ph.D., has decided to step down from the Board effective 19 November 2021.

“It is a pleasure to welcome Stephanie, an esteemed industry leader, to our Board of Directors”, said Frank Verwiel, M.D., Chairman of the Board of Directors of ObsEva. “Stephanie has a strong track record for building and transforming businesses with successful outcomes, translating organizational vision, and enhancing operational capabilities. She has deep experience in product launches and has brought highly specialized, breakthrough therapeutics from clinic to commercialization across many indications. Her strategic agility and diverse background will be invaluable as we execute on our path forward, continue to pursue regulatory approvals and advance linzagolix towards commercialization—with the goal of ultimately offering more individualized treatment options for a broader range of women. I, along with ObsEva’s entire board and leadership team, look forward to working with Stephanie. We would also like to thank Jacky for his scientific guidance, leadership, vision, and significant contributions to the Company over the last eight years. We are grateful to have had the opportunity to work closely with Jacky and we wish him continued success.”

Ms. Brown added, “I am delighted to join ObsEva, whose positive data from the Phase 3 PRIMROSE study suggests linzagolix has the potential to combine strong efficacy, favorable tolerability and offer unique dosing options for uterine fibroids. If approved, linzagolix would be the first and only GnRH receptor antagonist with a low dose option to address the needs of women who cannot or do not want to take hormones. I am incredibly excited about the potential of bringing this differentiated treatment to market, and I look forward to working with ObsEva’s exceptional team to advance the company’s mission.”

Ms. Brown brings over 30 years of experience in executive leadership with broad commercial expertise and accomplishments in the bio-pharma industry. In her executive level roles, her responsibilities have included commercial assessments and recommendations for business development, product development and portfolio planning. Most recently, Ms. Brown served as Senior Vice President and Head of the Rare Diseases Franchise, North America at Ipsen Pharmaceuticals. In this role, she was responsible for driving strategy, execution, revenue and profit for the rare diseases portfolio. She built the rare diseases business unit with responsibility for commercialization of in-line and launch brands including direction of marketing, sales, patient services, and excellence operations, in addition to oversight of all

other key commercial functions at Ipsen. Prior to Ipsen, Ms. Brown was Vice President and US Head of Novartis’ Neuroscience Franchise with responsibility for commercial marketing, sales and operations, and had oversight of market access, patient services and medical affairs. Earlier in her career, Ms. Brown held various elevating leadership roles at Takeda Pharmaceuticals US, Biogen, Genentech and Merck. Ms. Brown has chaired and governed inter-company collaborations and has chaired, co-chaired and served on multiple executive US and global governance committees. She has extensive Board experience and is currently an active member of the Board of Directors of the Biotechnology Innovation Organization (BIO), a biotechnology industry association in the US. Ms. Brown earned a B.S. in Chemistry with Biology from Mount Allison University, Canada, and an MBA from Heriot-Watt University, Scotland.

About Obseva

Obseva is a biopharmaceutical company built to address some of the most challenging unmet needs in women’s health – an under-researched, under-invested field of medicine. With deep expertise in clinical development, Obseva is passionate about the pursuit of advances that benefit women and their health and the importance of delivering truly meaningful innovation in this space. Through strategic in-licensing and disciplined drug development, Obseva has established a late-stage clinical pipeline with development programs focused on new therapies for the treatment of uterine fibroids, endometriosis, and preterm labor. Obseva is listed on the Nasdaq Global Select Market and is traded under the ticker symbol “OBSV” and on the SIX Swiss Exchange where it is traded under the ticker symbol “OBSN”. For more information, please visit www.ObsEva.com.

Cautionary Note Regarding Forward-Looking Statements

Any statements contained in this press release that do not describe historical facts may constitute forward-looking statements as that term is defined in the Private Securities Litigation Reform Act of 1995. These statements may be identified by words such as “believe”, “expect”, “may”, “plan”, “potential”, “will”, and similar expressions, and are based on Obseva’s current beliefs and expectations. These forward-looking statements include expectations regarding the clinical development and potential therapeutic and clinical benefits of and commercialization plans for Obseva’s product candidates, expectations regarding regulatory and development milestones, including the potential timing of and Obseva’s ability to obtain and maintain regulatory approvals for its product candidates, and the results of interactions with regulatory authorities. These statements involve risks and uncertainties that could cause actual results to differ materially from those reflected in such statements. Risks and uncertainties that may cause actual results to differ materially include uncertainties inherent in the conduct of clinical trials and clinical development, including the risk that the results of earlier clinical trials may not be predictive of the results of later stage clinical trials, related interactions with regulators, Obseva’s reliance on third parties over which it may not always have full control, and the capabilities of such third parties; the impact of the ongoing novel coronavirus outbreak, and other risks and uncertainties that are described in the Risk Factors section of Obseva’s Annual Report on Form 20-F for the year ended December 31, 2020 filed with Securities and Exchange Commission (SEC) on March 5, 2021 and in the Report on Form 6-K filed with the SEC on November 4, 2021, and other filings ObsEva makes with the SEC. These documents are available on the Investors page of Obseva’s website at www.Obseva.com. Any forward-looking statements speak only as of the date of this press release and are based on information available to Obseva as of the date of this release, and Obseva assumes no obligation to, and does not intend to, update any forward-looking statements, whether as a result of new information, future events or otherwise.

For further information, please contact:

CEO Office contact

Shauna Dillon

Shauna.dillon@obseva.ch

+41 22 552 1550

Investor Contact

Joyce Allaire

jallaire@lifesciadvisors.com

+1 (617) 435-6602