POWER OF ATTORNEY
Know all by these present, that Takeda A/S, a stock limited company
incorporated under the laws of Denmark, and with business address at Dybendal
Alle 10, 2630 Taastrup, Denmark ("Takeda A/S") hereby constitutes and appoints
each of Paul Sundberg, Chad Diehl and Brett Budzinski, signing singly, as Takeda
A/S 's true and lawful attorney-in-fact to:
(1) prepare, execute in Takeda A/S's name and on Takeda A/S's behalf, and
submit to the U.S. Securities and Exchange Commission (the "SEC") a
Form ID, including amendments thereto, and any other documents
necessary or appropriate to obtain codes and passwords enabling Takeda
A/S to make electronic filings with the SEC of Reports required by
Sections 13 and 16(a) of the Securities Exchange Act of 1934 or any
rule or regulation of the SEC;
{2) prepare and file on behalf of Takeda A/S any and all reports, notices,
communications and other documents (including, but not limited to,
reports on Schedule 13D, Schedule 13G, Form 3, Form 4 and Form 5) that
Takeda A/S may be required to file with the SEC pursuant to the
Securities Act of 1933, as amended (together with the implementing
regulations thereto, the "Act") and the Securities Exchange Act of
1934, as amended (together with the implementing regulations thereto,
the "Exchange Act") (collectively, the "Reports") with respect to
Takeda A/S's ownership of, or transactions in, the securities of any
entity whose securities are beneficially owned {directly or
indirectly) by Takeda A/S {each an "Portfolio Company" and
collectively "Portfolio Companies");
(3) do and perform any and all acts for and on behalf of Takeda A/S which
may be necessary or desirable to complete and execute any such
Reports, complete and execute any amendment or amendments thereto, and
timely file such form with the SEC and any stock exchange or similar
authority;
(4) complete for and on behalf of Takeda A/S, execute in Takeda A/S's name
and on Takeda A/S's behalf, and submit to the requestor thereof, any
questionnaires, documents or other materials that are requested in
connection with any (i) equity or debt offering by a Portfolio Company
and (ii) exercise by Takeda A/S of voting or proxy rights in
connection with Takeda A/S's equity ownership of any Portfolio
Company; and
(5) take any other action of any type whatsoever in connection with the
foregoing which, in the opinion of such attorney-in-fact, may be of
benefit to, in the best interest of, or legally required by, Takeda
A/S, it being understood that the documents executed by such attorney-
in-fact on behalf of Takeda A/S pursuant to this Power of Attorney
shall be in such form and shall contain such terms and conditions as
such attorney-in-fact may approve in such attorney-in-fact's
discretion.
Takeda A/S hereby grants to each such attorney-in-fact full power and
authority to do and perform any and every act and thing whatsoever requisite,
necessary, or proper to be done in the exercise of any of the rights and powers
herein granted, as fully to all intents and purposes as Takeda A/S might or
could do if the legal representatives of Takeda A/S were personally present,
hereby ratifying and confirming all that such attorney-in-fact shall lawfully do
or cause to be done by virtue of this power of attorney and the rights and
powers herein granted. Takeda A/S acknowledges that the foregoing attorneys-in-
fact, in serving in such capacity at the request of Takeda A/S, are not assuming
nor relieving any of Takeda A/S's responsibilities to comply with Section 13 or
Section 16 of the Exchange Act. Takeda A/S acknowledges that none of the
foregoing attorneys-in-fact assume (i) any liability for Takeda A/S's
responsibility to comply with the requirements of the Act or the Exchange Act,
(ii) any liability of Takeda A/S for any failure to comply with such
requirements or (iii) any obligation or liability of Takeda A/S for profit
disgorgement under Section 16(b) of the Exchange Act.
This Power of Attorney shall remain in full force and effect until Takeda
A/S is no longer required to file any Reports with respect to Takeda A/S's
ownership of, or transactions in, the securities of Portfolio Companies, unless
earlier revoked by Takeda A/S at any time at its sole discretion. This Power of
Attorney shall expire as to any individual attorney-in-fact if such attorney-in-
fact ceases to serve as an employee of Takeda Pharmaceutical Company Limited
(Japan) or one of its subsidiaries.
[Signature page follows]
IN WITNESS WHEREOF, Takeda A/S has caused this Power of Attorney to become
effective as of the date set forth below.
TAKEDA A/S
By: /s/ Patrik Forsell
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Name: Patrik Forsell
Title: Managing Director
Date: 12/12 - 2017
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