| Cover | Dec. 15, 2022 |
| Document Type | 8-K |
| Amendment Flag | false |
| Document Period End Date | Dec. 15, 2022 |
| Current Fiscal Year End Date | --12-31 |
| Entity File Number | 001-38105 |
| Entity Registrant Name | 180 LIFE SCIENCES CORP. |
| Entity Central Index Key | 0001690080 |
| Entity Tax Identification Number | 90-1890354 |
| Entity Incorporation, State or Country Code | DE |
| Entity Address, Address Line One | 3000 El Camino Real |
| Entity Address, Address Line Two | Bldg |
| Entity Address, Address Line Three | Suite 200 |
| Entity Address, City or Town | Palo Alto |
| Entity Address, State or Province | CA |
| Entity Address, Postal Zip Code | 94306 |
| City Area Code | 650 |
| Local Phone Number | 507-0669 |
| Written Communications | false |
| Soliciting Material | false |
| Pre-commencement Tender Offer | false |
| Pre-commencement Issuer Tender Offer | false |
| Entity Emerging Growth Company | true |
| Elected Not To Use the Extended Transition Period | false |
| Common Stock, par value $0.0001 per share | |
| Title of 12(b) Security | Common Stock, par value $0.0001 per share |
| Trading Symbol | ATNF |
| Security Exchange Name | NASDAQ |
| Warrants to purchase shares of Common Stock | |
| Title of 12(b) Security | Warrants to purchase shares of Common Stock |
| Trading Symbol | ATNFW |
| Security Exchange Name | NASDAQ |
