Dianthus Therapeutics (DNTH) 10-Q 9 May 19 2019 Q1 Quarterly report Financial data

Document and Entity Information

Document and Entity Information - shares	3 Months Ended
	Mar. 31, 2019	Apr. 30, 2019
Document Information [Line Items]
Document Type	10-Q
Amendment Flag	false
Document Period End Date	Mar. 31, 2019
Document Fiscal Year Focus	2019
Document Fiscal Period Focus	Q1
Trading Symbol	MGTA
Entity Registrant Name	MAGENTA THERAPEUTICS, INC.
Entity Central Index Key	0001690585
Current Fiscal Year End Date	--12-31
Entity Filer Category	Non-accelerated Filer
Entity Ex Transition Period	false
Entity Emerging Growth Company	true
Entity Small Business	true
Entity Common Stock, Shares Outstanding		33,653,362

Consolidated Balance Sheets

Consolidated Balance Sheets - USD ($) $ in Thousands	Mar. 31, 2019	Dec. 31, 2018
Current assets:
Cash and cash equivalents	$ 31,241	$ 58,345
Marketable securities	96,066	84,225
Prepaid expenses and other current assets	7,770	2,751
Total current assets	135,077	145,321
Restricted cash	1,780	1,780
Property and equipment, net	10,640	10,212
Deferred offering costs	195	0
Total assets	147,692	157,313
Current liabilities:
Accounts payable	3,010	3,492
Accrued expenses and other current liabilities	4,910	6,927
Total current liabilities	7,920	10,419
Deferred rent	5,769	1,246
Total liabilities	13,689	11,665
Commitments and contingencies (Note 7)
Stockholders' Equity:
Preferred stock, $0.001 par value; 10,000,000 shares authorized; no shares issued or outstanding
Common stock, $0.001 par value; 150,000,000 shares authorized; 34,406,781 shares and 34,327,554 shares issued and 33,581,975 shares and 33,305,033 shares outstanding as of March 31, 2019 and December 31, 2018, respectively	34	33
Additional paid-in capital	251,488	248,349
Accumulated other comprehensive income (loss)	41	(8)
Accumulated deficit	(117,560)	(102,726)
Total stockholders' equity	134,003	145,648
Total liabilities and stockholders' equity	$ 147,692	$ 157,313

Consolidated Balance Sheets (Pa

Consolidated Balance Sheets (Parenthetical) - $ / shares	Mar. 31, 2019	Dec. 31, 2018
Preferred stock, par value	$ 0.001	$ 0.001
Preferred stock, Shares authorized	10,000,000	10,000,000
Preferred stock, Shares issued	0	0
Preferred stock, Shares outstanding	0	0
Common stock, Par value	$ 0.001	$ 0.001
Common stock, shares authorized	150,000,000	150,000,000
Common stock, Shares issued	34,406,781	34,327,554
Common stock, Shares outstanding	33,581,975	33,305,033

Consolidated Statements of Oper

Consolidated Statements of Operations and Comprehensive Loss - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2019	Mar. 31, 2018
Revenue	$ 0	$ 0
Operating expenses:
Research and development	10,537	7,849
General and administrative	5,813	3,457
Total operating expenses	16,350	11,306
Loss from operations	(16,350)	(11,306)
Interest and other income, net	1,516	145
Net loss attributable to common stockholders	$ (14,834)	$ (11,161)
Net loss per share attributable to common stockholders, basic and diluted	$ (0.44)	$ (4.53)
Weighted average common shares outstanding, basic and diluted	33,422,278	2,466,353
Comprehensive loss:
Net loss	$ (14,834)	$ (11,161)
Other comprehensive income:
Unrealized gains (losses) on marketable securities	49
Total other comprehensive income	49
Total comprehensive loss	$ (14,785)	$ (11,161)

Consolidated Statements of Stoc

Consolidated Statements of Stockholders' Equity (Deficit) - USD ($) $ in Thousands	Total	Series A, B and C Redeemable Convertible Preferred Stock [Member]	Common Stock [Member]	Additional Paid-in Capital [Member]	Accumulated Other Comprehensive Income (Loss) [Member]	Accumulated Deficit [Member]
Beginning balance at Dec. 31, 2017		$ 92,439
Beginning balance at Dec. 31, 2017	$ (42,118)		$ 2	$ 3,091		$ (45,211)
Beginning balance, shares at Dec. 31, 2017		49,178,527
Beginning balance, shares at Dec. 31, 2017			2,351,247
Vesting of restricted stock			$ 1	(1)
Vesting of restricted stock, shares			269,032
Stock-based compensation expense	1,425			1,425
Net loss	(11,161)					(11,161)
Ending balance at Mar. 31, 2018		$ 92,439
Ending balance at Mar. 31, 2018	(51,854)		$ 3	4,515		(56,372)
Ending balance, shares at Mar. 31, 2018		49,178,527
Ending balance, shares at Mar. 31, 2018			2,620,279
Beginning balance at Dec. 31, 2017		$ 92,439
Beginning balance at Dec. 31, 2017	(42,118)		$ 2	3,091		(45,211)
Beginning balance, shares at Dec. 31, 2017		49,178,527
Beginning balance, shares at Dec. 31, 2017			2,351,247
Net loss	(57,500)
Ending balance at Dec. 31, 2018	145,648		$ 33	248,349	$ (8)	(102,726)
Ending balance, shares at Dec. 31, 2018			33,305,033
Vesting of restricted stock			$ 1	(1)
Vesting of restricted stock, shares			197,715
Issuance of common stock upon exercise of stock options	563			563
Issuance of common stock upon exercise of stock options, shares			79,227
Stock-based compensation expense	2,577			2,577
Unrealized loss on marketable securities	49				49
Net loss	(14,834)					(14,834)
Ending balance at Mar. 31, 2019	$ 134,003		$ 34	$ 251,488	$ 41	$ (117,560)
Ending balance, shares at Mar. 31, 2019			33,581,975

Consolidated Statements of Cash

Consolidated Statements of Cash Flows - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2019	Mar. 31, 2018
Cash flows from operating activities:
Net loss	$ (14,834)	$ (11,161)
Adjustments to reconcile net loss to net cash used in operating activities:
Stock-based compensation expense	2,577	1,425
Depreciation and amortization expense	423	147
Net accretion of discounts on marketable securities	(312)
Changes in operating assets and liabilities:
Prepaid expenses and other current assets	(5,019)	(60)
Accounts payable	(658)	1,206
Accrued expenses and other current liabilities	(1,636)	(1,161)
Deferred rent	4,523
Net cash used in operating activities	(14,936)	(9,604)
Cash flows from investing activities:
Purchases of property and equipment	(1,251)	(161)
Purchases of marketable securities	(18,980)
Maturities of marketable securities	7,500
Net cash used in investing activities	(12,731)	(161)
Cash flows from financing activities:
Payments of initial public offering costs		(166)
Payments of redeemable convertible preferred stock issuance costs		(9)
Proceeds from exercise of common stock options	563
Net cash provided by (used in) financing activities	563	(175)
Net decrease in cash, cash equivalents and restricted cash	(27,104)	(9,940)
Cash, cash equivalents and restricted cash at beginning of period	60,125	51,402
Cash, cash equivalents and restricted cash at end of period	33,021	41,462
Supplemental disclosure of non-cash investing and financing activities:
Purchase of property and equipment included in accounts payable and accrued expenses	1,138	85
Deferred offering and redeemable convertible preferred share issuance costs included in accounts payable or accrued expenses	$ 195	$ 1,221

Nature of the Business and Basi

Nature of the Business and Basis of Presentation	3 Months Ended
	Mar. 31, 2019
Nature of the Business and Basis of Presentation	1. Nature of the Business and Basis of Presentation Magenta Therapeutics, Inc. (the “Company”) is a clinical-stage biopharmaceutical company developing novel medicines to bring the curative power of stem cell transplant to more patients. The Company was incorporated under the laws of the State of Delaware in June 2015 as HSCTCo Therapeutics, Inc. In February 2016, the Company changed its name to Magenta Therapeutics, Inc. The Company is subject to risks and uncertainties common to early-stage companies in the biotechnology industry, including, but not limited to, development by competitors of new technological innovations, dependence on key personnel, protection of proprietary technology, compliance with government regulations and the ability to secure additional capital to fund operations. Product candidates currently under development will require significant additional research and development efforts, including extensive preclinical and clinical testing and regulatory approval prior to commercialization. These efforts require significant amounts of additional capital, adequate personnel and infrastructure and extensive compliance-reporting capabilities. Even if the Company’s drug development efforts are successful, it is uncertain when, if ever, the Company will realize significant revenue from product sales. On June 25, 2018, the Company completed its initial public offering (“IPO”) pursuant to which it issued and sold 6,666,667 shares of common stock at a public offering price of $15.00 per share, resulting in net proceeds of $89.9 million, after deducting underwriting discounts and commissions and other offering expenses. Upon the closing of the IPO, the Company’s outstanding redeemable convertible preferred stock automatically converted into shares of common stock. The Company has incurred recurring losses since inception, including net losses of $14.8 million and $57.5 million, respectively, for the three months ended March 31, 2019 and the year ended December 31, 2018. As of March 31, 2019, the Company had an accumulated deficit of $117.6 million. The Company expects to continue to generate operating losses for the foreseeable future. The Company expects that its cash, cash equivalents and marketable securities will be sufficient to fund its operating expenses and capital expenditure requirements through at least 12 months from the issuance date of these consolidated financial statements. The future viability of the Company beyond that point is dependent on its ability to raise additional capital to fund its operations. The Company expects its expenses to increase substantially in connection with ongoing activities, particularly as the Company advances its preclinical activities and clinical trials for its product candidates in development. Accordingly, the Company will need to obtain substantial additional funding in connection with continuing operations. If the Company is unable to raise capital when needed, or on attractive terms, it could be forced to delay, reduce or eliminate its research or drug development programs or any future commercialization efforts. Although management continues to pursue these plans, there is no assurance that the Company will be successful in obtaining sufficient funding on terms acceptable to the Company to fund continuing operations, if at all. The consolidated financial statements include the accounts of the Company and its wholly owned subsidiary. All intercompany balances and transactions have been eliminated. The consolidated financial statements have been prepared in accordance with accounting principles generally accepted in the United States of America (“GAAP”).

Summary of Significant Accounti

Summary of Significant Accounting Policies	3 Months Ended
	Mar. 31, 2019
Summary of Significant Accounting Policies	2. Summary of Significant Accounting Policies Use of Estimates The preparation of financial statements in conformity with GAAP requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities, the disclosure of contingent assets and liabilities at the date of the financial statements and the reported amounts of expenses during the reporting periods. Significant estimates and assumptions reflected in these financial statements include, but are not limited to, the accrual for research and development expenses and the valuation of stock-based awards. Estimates are periodically reviewed in light of changes in circumstances, facts and experience. Changes in estimates are recorded in the period in which they become known. Actual results could differ from those estimates. Unaudited Interim Financial Information The consolidated balance sheet at December 31, 2018 was derived from audited financial statements but does not include all disclosures required by GAAP. The accompanying unaudited consolidated financial statements as of March 31, 2019 and for the three months ended March 31, 2019 and 2018 have been prepared by the Company pursuant to the rules and regulations of the Securities and Exchange Commission (“SEC”) for interim financial statements. Certain information and footnote disclosures normally included in financial statements prepared in accordance with GAAP have been condensed or omitted pursuant to such rules and regulations. The Company believes, however, that the disclosures are adequate to make the information presented not misleading. These consolidated financial statements should be read in conjunction with the Company’s audited financial statements for the year ended December 31, 2018 included in the Company’s Annual Report on Form 10-K, Deferred Offering Costs The Company capitalizes certain legal, professional accounting and other third-party fees that are directly associated with in-process paid-in in-process Fair Value Measurements Certain assets and liabilities are carried at fair value under GAAP. Fair value is defined as the exchange price that would be received for an asset or paid to transfer a liability (an exit price) in the principal or most advantageous market for the asset or liability in an orderly transaction between market participants on the measurement date. Valuation techniques used to measure fair value must maximize the use of observable inputs and minimize the use of unobservable inputs. Financial assets and liabilities carried at fair value are to be classified and disclosed in one of the following three levels of the fair value hierarchy, of which the first two are considered observable and the last is considered unobservable: • Level 1—Quoted prices in active markets for identical assets or liabilities. • Level 2—Observable inputs (other than Level 1 quoted prices), such as quoted prices in active markets for similar assets or liabilities, quoted prices in markets that are not active for identical or similar assets or liabilities, or other inputs that are observable or can be corroborated by observable market data. • Level 3—Unobservable inputs that are supported by little or no market activity and that are significant to determining the fair value of the assets or liabilities, including pricing models, discounted cash flow methodologies and similar techniques. The Company’s cash equivalents and marketable securities are carried at fair value, determined according to the fair value hierarchy described above (see Note 3). The carrying values of the Company’s accounts payable and accrued expenses approximate their fair values due to the short-term nature of these assets and liabilities. Income Taxes The Company accounts for income taxes using the asset and liability method, which requires the recognition of deferred tax assets and liabilities for the expected future tax consequences of events that have been recognized in the consolidated financial statements or in the Company’s tax returns. Deferred taxes are determined based on the difference between the financial statement and tax basis of assets and liabilities using enacted tax rates in effect in the years in which the differences are expected to reverse. Changes in deferred tax assets and liabilities are recorded in the provision for income taxes. The Company assesses the likelihood that its deferred tax assets will be recovered from future taxable income and, to the extent it believes, based upon the weight of available evidence, that it is more likely than not that all or a portion of deferred tax assets will not be realized, a valuation allowance is established through a charge to income tax expense. Potential for recovery of deferred tax assets is evaluated by estimating the future taxable profits expected and considering prudent and feasible tax planning strategies. The Company accounts for uncertainty in income taxes recognized in its consolidated financial statements by applying a two-step more-likely-than-not Comprehensive Loss Comprehensive loss includes net loss as well as other changes in stockholders’ equity that result from transactions and economic events other than those with stockholders. For the three months ended March 31, 2019, the Company’s only element of other comprehensive loss was unrealized gains (losses) on marketable securities. For the three months ended March 31, 2018, there was no difference between net loss and comprehensive loss. Net Loss per Share Prior to the closing of its IPO, the Company followed the two-class two-class two-class Subsequent to the closing of its IPO, basic net income (loss) per common share is computed by dividing the net income (loss) by the weighted average number of shares of common stock outstanding for the period. Diluted net income (loss) per common share is computed by dividing net income (loss) by the weighted average number of common shares outstanding for the period, including potential dilutive common shares assuming the dilutive effect of outstanding stock options. For periods in which the Company has reported net losses, diluted net loss per common share is the same as basic net loss per common share, since dilutive common shares are not assumed to have been issued if their affect is anti-dilutive. In June 2018, upon the closing of the IPO, all outstanding shares of the Company’s redeemable convertible preferred stock automatically converted into 23,375,405 shares of the Company’s common stock. The Company reported a net loss attributable to common stockholders for the three months ended March 31, 2019 and 2018. Classification and Accretion of Redeemable Convertible Preferred Stock Prior to the conversion of the redeemable convertible preferred stock to common stock in connection with the IPO, the Company had classified redeemable convertible preferred stock outside of stockholders’ equity (deficit) because the shares contained certain redemption features that were not solely within the control of the Company. The Company immediately accreted the carrying value of its redeemable convertible preferred stock to redemption value at the end of each reporting period as if the end of the reporting period were the redemption date. Recently Adopted Accounting Pronouncements In June 2018, the Financing Accounting Standards Board (the “FASB”) issued Accounting Standards Update (“ASU”) No. 2018-07, Compensation – Stock Compensation (Topic 718), Improvements to Nonemployee Share-Based Payment Accounting 2018-07”). 2018-07 non-public 2018-07 No. 2014-09, Revenue from Contracts with Customers (Topic 606) 2018-07 non-employees 2018-07 non-employee non-employee Recently Issued Accounting Pronouncements In February 2016, the FASB issued ASU No. 2016-02, Leases 2016-02”). 2016-02 right-of-use non-public 2016-02 2018-11, Leases (Topic 842) Targeted Improvements 2016-02 2016-02

Fair Value of Financial Assets

Fair Value of Financial Assets	3 Months Ended
	Mar. 31, 2019
Fair Value of Financial Assets	3. Fair Value of Financial Assets As of March 31, 2019, marketable securities by security type consisted of (in thousands): Amortized Gross Gross Estimated United States Treasury Notes (due within one year) $ 79,690 $ 30 $ (1 ) $ 79,719 Agency Bonds (due within one year) 16,335 12 — 16,347 Total $ 96,025 $ 42 $ (1 ) $ 96,066 As of December 31, 2018, marketable securities by security type consisted of (in thousands): Amortized Gross Gross Estimated United States Treasury Notes (due within one year) $ 71,944 $ 5 $ (9 ) $ 71,940 Agency Bonds (due within one year) 12,289 1 (5 ) 12,285 Total $ 84,233 $ 6 $ (14 ) $ 84,225 The following tables present information about the Company’s financial assets measured at fair value on a recurring basis and indicate the level of the fair value hierarchy utilized to determine such fair values (in thousands): Fair Value Measurements at March 31, 2019 Level 1 Level 2 Level 3 Total Cash equivalents: Money market funds $ 31,189 $ — $ — $ 31,189 Marketable securities: United States Treasury Notes — 79,719 — 79,719 Agency Bonds — 16,347 — 16,347 Total $ 31,189 $ 96,066 $ — $ 127,255 Fair Value Measurements at December 31, 2018 Level 1 Level 2 Level 3 Total Cash equivalents: Money market funds $ 45,725 $ — $ — $ 45,725 United States Treasury Notes — 12,488 — 12,488 Marketable securities: United States Treasury Notes — 71,940 — 71,940 Agency Bonds — 12,285 — 12,285 Total $ 45,725 $ 96,713 $ — $ 142,438 During the three months ended March 31, 2019, there were no transfers between Level 1, Level 2 and Level 3.

Accrued Expenses and Other Curr

Accrued Expenses and Other Current Liabilities	3 Months Ended
	Mar. 31, 2019
Accrued Expenses and Other Current Liabilities	4. Accrued Expenses and Other Current Liabilities Accrued expenses and other current liabilities consisted of the following (in thousands): March 31, December 31, Accrued external research and development expenses $ 2,108 $ 2,619 Accrued payroll and related expenses 1,038 2,526 Accrued professional fees 740 787 Deferred rent, current portion 601 71 Accrued leasehold improvements 190 501 Accrued other 233 423 $ 4,910 $ 6,927

Stock-Based Awards

Stock-Based Awards	3 Months Ended
	Mar. 31, 2019
Stock-Based Awards	5. Stock-Based Awards The Company grants stock-based awards under its 2018 Stock Option and Incentive Plan (the “2018 Plan”). The Company also has outstanding stock options under its 2016 Stock Option and Grant Plan (the “2016 Plan”), but is no longer granting awards under this plan. As of March 31, 2019, 2,786,567 shares of common stock were available for issuance under the 2018 Plan. Grant of Stock Options During the three months ended March 31, 2019, the Company granted options to certain employees with service-based vesting for the purchase of 1,301,685 shares of common stock with a weighted average grant date fair value of $5.04 per share. Stock-Based Compensation Stock-based compensation expense was classified in the statements of operations and comprehensive loss as follows (in thousands): Three Months 2019 2018 Research and development expenses $ 1,256 $ 891 General and administrative expenses 1,321 534 $ 2,577 $ 1,425 As of March 31, 2019, total unrecognized compensation cost related to unvested share-based awards was $20.3 million, which is expected to be recognized over a weighted average period of 2.6 years. Prior to the adoption of ASU 2018-07 non-employees non-employee 2018-07, non-employees

Net Loss per Share

Net Loss per Share	3 Months Ended
	Mar. 31, 2019
Net Loss per Share	6. Net Loss per Share Basic and diluted net loss per share attributable to common stockholders was calculated as follows (in thousands, except share and per share amounts): Three Months Ended March 31, 2019 2018 Numerator: Net loss $ (14,834 ) $ (11,161 ) Net loss attributable to common stockholders $ (14,834 ) $ (11,161 ) Denominator: Weighted average common shares outstanding, basic and diluted 33,422,278 2,466,353 Net loss per share attributable to common stockholders, basic and diluted $ (0.44 ) $ (4.53 ) Common Stock Equivalents The following potential dilutive securities, presented based on amounts outstanding at each period end, have been excluded from the calculation of diluted net loss per share because including them would have had an anti-dilutive impact: March 31, 2019 2018 Stock options to purchase common stock 4,670,165 1,386,577 Unvested restricted common stock 824,806 1,828,188 Redeemable convertible preferred stock (as converted to common stock) — 19,032,066 5,494,971 22,246,831

Commitments and Contingencies

Commitments and Contingencies	3 Months Ended
	Mar. 31, 2019
Commitments and Contingencies	7. Commitments and Contingencies Leases In May 2018, the Company entered into a sublease for up to approximately 69,000 square feet of office and laboratory space in Cambridge, Massachusetts. The sublease was amended effective March 2019 to increase the lease payments over the lease term and to increase the sublandlord-funded tenant improvements. The sublease is subject and subordinate to a prime lease between the sublandlord and the prime landlord. The term of the sublease commenced in June 2018 and expires in February 2028. The sublandlord has the right to terminate the sublease after five years. The Company is also obligated to pay real estate taxes and other costs related to the premises, including costs of operations and management of the leased premises. In connection with the sublease, as amended, the sublandlord agreed to fund up to $5.5 million in tenant improvements to the leased facility and a receivable of $5.5 million and $0.7 million was included in prepaid expenses and other current assets at March 31, 2019 and December 31, 2018, respectively. The Company is required to maintain a cash balance of $1.8 million to secure a letter of credit associated with the sublease. This amount was classified as noncurrent restricted cash in the consolidated balance sheets at March 31, 2019 and December 31, 2018. The tenant improvement allowance and payment escalations specified in the sublease agreement are accrued or deferred as appropriate such that rent expense per square foot is recognized on a straight-line basis over the terms of occupancy. As of March 31, 2019 and December 31, 2018, the Company had long-term deferred rent of $5.8 million and $1.2 million, respectively, related to lease incentives and payment escalations. As of March 31, 2019 and December 31, 2018, the short-term portion of deferred rent of $0.6 million and $0.1 million, respectively, was included in accrued expenses and other current liabilities. The Company recorded rent expense of $1.5 million and $0.3 million during the three months ended March 31, 2019 and 2018, respectively. In the fourth quarter of 2018, with the landlord’s consent, the Company entered into two two-year sub-subleases sub-sublease As of March 31, 2019, the future minimum lease payments due under the noncancelable operating lease is as follows (in thousands): Remainder of 2019 (nine months) $ 4,169 2020 5,782 2021 6,072 2022 6,375 2023 6,734 Thereafter 32,000 $ 61,132 Collaboration Agreement In March 2018, the Company entered into a collaboration agreement with Heidelberg Pharma Research GmbH (“HDPR”) whereby the parties agreed to combine the Company’s stem cell platform with proprietary antibodies across up to four exclusive targets with HDPR’s proprietary Antibody Targeted Amanitin Conjugates platform. Under the agreement, the Company may pay upfront technology access fees, research exclusivity fees and payment for research support. Additionally, upon the exercise of certain license rights, the Company may be obligated to pay HDPR development, regulatory and commercial milestone payments of up to $83.5 million per target as well as royalties on net sales of products licensed under the agreement. During the three months ended March 31, 2019 and 2018, the Company recorded $0.4 million and $0.7 million, respectively, of research and development expense related to this agreement for upfront technology access fees, research exclusivity fees and research support. Intellectual Property Licenses In November 2016, the Company entered into a license agreement with the President and Fellows of Harvard College (“Harvard”) for an exclusive, worldwide, royalty-bearing license for certain technologies related to conditioning and mobilization. In consideration for these rights the Company paid Harvard an upfront fee of $0.1 million and reimbursed Harvard $0.3 million for costs incurred by Harvard related to the patented technology, which amounts were recorded as research and development expense during the year ended December 31, 2016. The Company also issued 385,063 shares of common stock in connection with the license agreement. The fair value of the shares of $0.3 million as of the issuance date was recorded as research and development expense during the year ended December 31, 2016. The Company is obligated to pay Harvard maintenance fees of less than $0.1 million annually through 2019 and $0.1 million annually thereafter and to reimburse qualified expenses related to the patents. The Company is also obligated to pay milestone payments of up to $7.4 million for the first two licensed products upon the achievement of certain development and regulatory milestones and to pay royalties on a product-by-product country-by-country In April 2017, the Company entered into a license agreement with Novartis International Pharmaceutical Ltd. (“Novartis”) to use and develop certain patent rights (the “Novartis License”). Under the Novartis License, the Company was granted an exclusive, worldwide, sublicensable license to research, develop and commercialize certain licensed products that contain Novartis compounds for the expansion of cord blood derived non-gene-edited/-modified product-by-product country-by-country The Company has agreements with third parties in the normal course of business, under which it can license certain developed technologies. If the Company exercises its rights to license the respective technologies, it may be subject to additional fees and milestone payments. During the three months ended March 31, 2019 and 2018, the Company did not exercise its rights to the license of certain developed technologies under these agreements. Indemnification Agreements In the ordinary course of business, the Company may provide indemnification of varying scope and terms to vendors, lessors, business partners and other parties with respect to certain matters including, but not limited to, losses arising out of breach of such agreements or from intellectual property infringement claims made by third parties. In addition, the Company has entered into indemnification agreements with members of its board of directors and senior management that will require the Company, among other things, to indemnify them against certain liabilities that may arise by reason of their status or service as directors or officers. The maximum potential amount of future payments the Company could be required to make under these indemnification agreements is, in many cases, unlimited. To date, the Company has not incurred any material costs as a result of such indemnifications. The Company is not aware of any claims under indemnification arrangements, and it has not accrued any liabilities related to such obligations in its consolidated financial statements as of March 31, 2019 and December 31, 2018. Legal Proceedings The Company is not currently a party to any material legal proceedings. At each reporting date, the Company evaluates whether or not a potential loss amount or a potential range of loss is probable and reasonably estimable under the provisions of the authoritative guidance that addresses accounting for contingencies. The Company expenses the costs related to its legal proceedings as they are incurred.

401(k) Savings Plan

401(k) Savings Plan	3 Months Ended
	Mar. 31, 2019
401(k) Savings Plan	8. 401(k) Savings Plan The Company has a 401(k) available for participating employees who meet certain eligibility requirements. Eligible employees may defer a portion of their salary as defined by the plan. Company contributions to the plan may be made at the discretion of the board of directors of the Company. To date, the Company has not made any contributions to the plan.

Related Parties

Related Parties	3 Months Ended
	Mar. 31, 2019
Related Parties	9. Related Parties Be The Match BioTherapies, LLC Effective March 2018, the President of Be The Match BioTherapies, LLC became a member of the Company’s board of directors. The Company has a collaboration agreement with Be The Match BioTherapies, LLC and a research agreement with an affiliated organization, Center for International Blood and Marrow Transplant Research. During the three months ended March 31, 2019 and 2018, the Company recorded less than $0.1 million and $0.2 million, respectively, to research and development expenses and less than $0.1 million during each of the three months ended March 31, 2019 and 2018 to general and administrative expenses and made payments of $0.4 million and $0.2 million, respectively, related to these agreements. As of March 31, 2019 and December 31, 2018, amounts on the balance sheet related to these agreements was less than $0.1 million and $0.4 million, respectively, which were included in accounts payable and accrued expenses and other current liabilities.

Subsequent Event

Subsequent Event	3 Months Ended
	Mar. 31, 2019
Subsequent Event	10. Subsequent Event In May 2019, the Company issued and sold 4,887,500 shares of its common stock, including the underwriters’ exercise in full of their option to purchase additional shares of common stock, in a follow-on

Summary of Significant Accoun_2

Summary of Significant Accounting Policies (Policies)	3 Months Ended
	Mar. 31, 2019
Use of Estimates	Use of Estimates The preparation of financial statements in conformity with GAAP requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities, the disclosure of contingent assets and liabilities at the date of the financial statements and the reported amounts of expenses during the reporting periods. Significant estimates and assumptions reflected in these financial statements include, but are not limited to, the accrual for research and development expenses and the valuation of stock-based awards. Estimates are periodically reviewed in light of changes in circumstances, facts and experience. Changes in estimates are recorded in the period in which they become known. Actual results could differ from those estimates.
Unaudited Interim Financial Information	Unaudited Interim Financial Information The consolidated balance sheet at December 31, 2018 was derived from audited financial statements but does not include all disclosures required by GAAP. The accompanying unaudited consolidated financial statements as of March 31, 2019 and for the three months ended March 31, 2019 and 2018 have been prepared by the Company pursuant to the rules and regulations of the Securities and Exchange Commission (“SEC”) for interim financial statements. Certain information and footnote disclosures normally included in financial statements prepared in accordance with GAAP have been condensed or omitted pursuant to such rules and regulations. The Company believes, however, that the disclosures are adequate to make the information presented not misleading. These consolidated financial statements should be read in conjunction with the Company’s audited financial statements for the year ended December 31, 2018 included in the Company’s Annual Report on Form 10-K,
Deferred Offering Costs	Deferred Offering Costs The Company capitalizes certain legal, professional accounting and other third-party fees that are directly associated with in-process paid-in in-process
Fair Value Measurements	Fair Value Measurements Certain assets and liabilities are carried at fair value under GAAP. Fair value is defined as the exchange price that would be received for an asset or paid to transfer a liability (an exit price) in the principal or most advantageous market for the asset or liability in an orderly transaction between market participants on the measurement date. Valuation techniques used to measure fair value must maximize the use of observable inputs and minimize the use of unobservable inputs. Financial assets and liabilities carried at fair value are to be classified and disclosed in one of the following three levels of the fair value hierarchy, of which the first two are considered observable and the last is considered unobservable: • Level 1—Quoted prices in active markets for identical assets or liabilities. • Level 2—Observable inputs (other than Level 1 quoted prices), such as quoted prices in active markets for similar assets or liabilities, quoted prices in markets that are not active for identical or similar assets or liabilities, or other inputs that are observable or can be corroborated by observable market data. • Level 3—Unobservable inputs that are supported by little or no market activity and that are significant to determining the fair value of the assets or liabilities, including pricing models, discounted cash flow methodologies and similar techniques. The Company’s cash equivalents and marketable securities are carried at fair value, determined according to the fair value hierarchy described above (see Note 3). The carrying values of the Company’s accounts payable and accrued expenses approximate their fair values due to the short-term nature of these assets and liabilities.
Income Taxes	Income Taxes The Company accounts for income taxes using the asset and liability method, which requires the recognition of deferred tax assets and liabilities for the expected future tax consequences of events that have been recognized in the consolidated financial statements or in the Company’s tax returns. Deferred taxes are determined based on the difference between the financial statement and tax basis of assets and liabilities using enacted tax rates in effect in the years in which the differences are expected to reverse. Changes in deferred tax assets and liabilities are recorded in the provision for income taxes. The Company assesses the likelihood that its deferred tax assets will be recovered from future taxable income and, to the extent it believes, based upon the weight of available evidence, that it is more likely than not that all or a portion of deferred tax assets will not be realized, a valuation allowance is established through a charge to income tax expense. Potential for recovery of deferred tax assets is evaluated by estimating the future taxable profits expected and considering prudent and feasible tax planning strategies. The Company accounts for uncertainty in income taxes recognized in its consolidated financial statements by applying a two-step more-likely-than-not
Comprehensive Loss	Comprehensive Loss Comprehensive loss includes net loss as well as other changes in stockholders’ equity that result from transactions and economic events other than those with stockholders. For the three months ended March 31, 2019, the Company’s only element of other comprehensive loss was unrealized gains (losses) on marketable securities. For the three months ended March 31, 2018, there was no difference between net loss and comprehensive loss.
Net Loss per Share	Net Loss per Share Prior to the closing of its IPO, the Company followed the two-class two-class two-class Subsequent to the closing of its IPO, basic net income (loss) per common share is computed by dividing the net income (loss) by the weighted average number of shares of common stock outstanding for the period. Diluted net income (loss) per common share is computed by dividing net income (loss) by the weighted average number of common shares outstanding for the period, including potential dilutive common shares assuming the dilutive effect of outstanding stock options. For periods in which the Company has reported net losses, diluted net loss per common share is the same as basic net loss per common share, since dilutive common shares are not assumed to have been issued if their affect is anti-dilutive. In June 2018, upon the closing of the IPO, all outstanding shares of the Company’s redeemable convertible preferred stock automatically converted into 23,375,405 shares of the Company’s common stock. The Company reported a net loss attributable to common stockholders for the three months ended March 31, 2019 and 2018.
Classification and Accretion of Redeemable Convertible Preferred Stock	Classification and Accretion of Redeemable Convertible Preferred Stock Prior to the conversion of the redeemable convertible preferred stock to common stock in connection with the IPO, the Company had classified redeemable convertible preferred stock outside of stockholders’ equity (deficit) because the shares contained certain redemption features that were not solely within the control of the Company. The Company immediately accreted the carrying value of its redeemable convertible preferred stock to redemption value at the end of each reporting period as if the end of the reporting period were the redemption date.
Recently Adopted Accounting Pronouncements and Recently Issued Accounting Pronouncements	Recently Adopted Accounting Pronouncements In June 2018, the Financing Accounting Standards Board (the “FASB”) issued Accounting Standards Update (“ASU”) No. 2018-07, Compensation – Stock Compensation (Topic 718), Improvements to Nonemployee Share-Based Payment Accounting 2018-07”). 2018-07 non-public 2018-07 No. 2014-09, Revenue from Contracts with Customers (Topic 606) 2018-07 non-employees 2018-07 non-employee non-employee Recently Issued Accounting Pronouncements In February 2016, the FASB issued ASU No. 2016-02, Leases 2016-02”). 2016-02 right-of-use non-public 2016-02 2018-11, Leases (Topic 842) Targeted Improvements 2016-02 2016-02

Fair Value of Financial Assets

Fair Value of Financial Assets (Tables)	3 Months Ended
	Mar. 31, 2019
Schedule of Marketable Securities by Security Type	As of March 31, 2019, marketable securities by security type consisted of (in thousands): Amortized Gross Gross Estimated United States Treasury Notes (due within one year) $ 79,690 $ 30 $ (1 ) $ 79,719 Agency Bonds (due within one year) 16,335 12 — 16,347 Total $ 96,025 $ 42 $ (1 ) $ 96,066 As of December 31, 2018, marketable securities by security type consisted of (in thousands): Amortized Gross Gross Estimated United States Treasury Notes (due within one year) $ 71,944 $ 5 $ (9 ) $ 71,940 Agency Bonds (due within one year) 12,289 1 (5 ) 12,285 Total $ 84,233 $ 6 $ (14 ) $ 84,225
Schedule of Financial Assets Measured at Fair Value on Recurring Basis	The following tables present information about the Company’s financial assets measured at fair value on a recurring basis and indicate the level of the fair value hierarchy utilized to determine such fair values (in thousands): Fair Value Measurements at March 31, 2019 Level 1 Level 2 Level 3 Total Cash equivalents: Money market funds $ 31,189 $ — $ — $ 31,189 Marketable securities: United States Treasury Notes — 79,719 — 79,719 Agency Bonds — 16,347 — 16,347 Total $ 31,189 $ 96,066 $ — $ 127,255 Fair Value Measurements at December 31, 2018 Level 1 Level 2 Level 3 Total Cash equivalents: Money market funds $ 45,725 $ — $ — $ 45,725 United States Treasury Notes — 12,488 — 12,488 Marketable securities: United States Treasury Notes — 71,940 — 71,940 Agency Bonds — 12,285 — 12,285 Total $ 45,725 $ 96,713 $ — $ 142,438

Accrued Expenses and Other Cu_2

Accrued Expenses and Other Current Liabilities (Tables)	3 Months Ended
	Mar. 31, 2019
Schedule of Accrued Expenses and Other Current Liabilities	Accrued expenses and other current liabilities consisted of the following (in thousands): March 31, December 31, Accrued external research and development expenses $ 2,108 $ 2,619 Accrued payroll and related expenses 1,038 2,526 Accrued professional fees 740 787 Deferred rent, current portion 601 71 Accrued leasehold improvements 190 501 Accrued other 233 423 $ 4,910 $ 6,927

Stock-Based Awards (Tables)

Stock-Based Awards (Tables)	3 Months Ended
	Mar. 31, 2019
Schedule of Stock Based Compensation Expense	Stock-based compensation expense was classified in the statements of operations and comprehensive loss as follows (in thousands): Three Months 2019 2018 Research and development expenses $ 1,256 $ 891 General and administrative expenses 1,321 534 $ 2,577 $ 1,425

Net Loss per Share (Tables)

Net Loss per Share (Tables)	3 Months Ended
	Mar. 31, 2019
Schedule of Basic and Diluted Net Loss Per Share Attributable to Common Stockholders	Basic and diluted net loss per share attributable to common stockholders was calculated as follows (in thousands, except share and per share amounts): Three Months Ended March 31, 2019 2018 Numerator: Net loss $ (14,834 ) $ (11,161 ) Net loss attributable to common stockholders $ (14,834 ) $ (11,161 ) Denominator: Weighted average common shares outstanding, basic and diluted 33,422,278 2,466,353 Net loss per share attributable to common stockholders, basic and diluted $ (0.44 ) $ (4.53 )
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share	The following potential dilutive securities, presented based on amounts outstanding at each period end, have been excluded from the calculation of diluted net loss per share because including them would have had an anti-dilutive impact: March 31, 2019 2018 Stock options to purchase common stock 4,670,165 1,386,577 Unvested restricted common stock 824,806 1,828,188 Redeemable convertible preferred stock (as converted to common stock) — 19,032,066 5,494,971 22,246,831

Commitments and Contingencies (

Commitments and Contingencies (Tables)	3 Months Ended
	Mar. 31, 2019
Schedule of Future Minimum Lease Payments Due Under Noncancelable Operating Lease	As of March 31, 2019, the future minimum lease payments due under the noncancelable operating lease is as follows (in thousands): Remainder of 2019 (nine months) $ 4,169 2020 5,782 2021 6,072 2022 6,375 2023 6,734 Thereafter 32,000 $ 61,132

Nature of the Business and Ba_2

Nature of the Business and Basis of Presentation - Additional Information (Detail) - USD ($) $ / shares in Units, $ in Thousands	Jun. 25, 2018	Mar. 31, 2019	Mar. 31, 2018	Dec. 31, 2018
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items]
Entity incorporation date		Jun. 30, 2015
Entity incorporation state name		State of Delaware
Net loss		$ (14,834)	$ (11,161)	$ (57,500)
Accumulated deficit		$ (117,560)		$ (102,726)
Common Stock [Member] | IPO [Member]
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items]
Stock issued, shares	6,666,667
Stock issued, price per shares	$ 15
Net proceeds from initial public offering	$ 89,900

Summary of Significant Accoun_3

Summary of Significant Accounting Policies - Additional Information (Detail) - USD ($) $ in Thousands	Mar. 31, 2019	Dec. 31, 2018	Jun. 25, 2018
Summary Of Significant Accounting Policies [Line Items]
Deferred offering costs	$ 195	$ 0
Redeemable convertible preferred stock converted into common stock shares			23,375,405

Fair Value of Financial Asset_2

Fair Value of Financial Assets - Schedule of Marketable Securities by Security Type (Detail) - USD ($) $ in Thousands	Mar. 31, 2019	Dec. 31, 2018
Marketable Securities [Line Items]
Amortized Cost	$ 96,025	$ 84,233
Gross Unrealized Gains	42	6
Gross Unrealized Losses	(1)	(14)
Estimated Fair Value	96,066	84,225
United States Treasury Notes [Member]
Marketable Securities [Line Items]
Amortized Cost	79,690	71,944
Gross Unrealized Gains	30	5
Gross Unrealized Losses	(1)	(9)
Estimated Fair Value	79,719	71,940
Agency Bonds [Member]
Marketable Securities [Line Items]
Amortized Cost	16,335	12,289
Gross Unrealized Gains	12	1
Gross Unrealized Losses		(5)
Estimated Fair Value	$ 16,347	$ 12,285

Fair Value of Financial Asset_3

Fair Value of Financial Assets - Schedule of Financial Assets Measured at Fair Value on Recurring Basis (Detail) - Fair Value on Recurring Basis [Member] - USD ($) $ in Thousands	Mar. 31, 2019	Dec. 31, 2018
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Financial Assets Measured at Fair Value on Recurring Basis	$ 127,255	$ 142,438
United States Treasury Notes [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Financial Assets Measured at Fair Value on Recurring Basis	79,719	71,940
Agency Bonds [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Financial Assets Measured at Fair Value on Recurring Basis	16,347	12,285
Money Market Funds [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Financial Assets Measured at Fair Value on Recurring Basis	31,189	45,725
United States Treasury Notes [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Financial Assets Measured at Fair Value on Recurring Basis		12,488
Level 1 [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Financial Assets Measured at Fair Value on Recurring Basis	31,189	45,725
Level 1 [Member] | Money Market Funds [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Financial Assets Measured at Fair Value on Recurring Basis	31,189	45,725
Level 2 [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Financial Assets Measured at Fair Value on Recurring Basis	96,066	96,713
Level 2 [Member] | United States Treasury Notes [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Financial Assets Measured at Fair Value on Recurring Basis	79,719	71,940
Level 2 [Member] | Agency Bonds [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Financial Assets Measured at Fair Value on Recurring Basis	$ 16,347	12,285
Level 2 [Member] | United States Treasury Notes [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Financial Assets Measured at Fair Value on Recurring Basis		$ 12,488

Fair Value of Financial Asset_4

Fair Value of Financial Assets - Additional Information (Detail)	3 Months Ended
	Mar. 31, 2019USD ($)
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Fair value, assets, level 1 to level 2 transfers, amount	$ 0
Fair value, assets, level 2 to level 1 transfers, amount	0
Fair value, measurement with unobservable inputs reconciliation, recurring basis, asset transfers into level 3	0
Fair value, measurement with unobservable inputs reconciliation, recurring basis, asset, transfers out of level 3	$ 0

Accrued Expenses and Other Cu_3

Accrued Expenses and Other Current Liabilities - Schedule of Accrued Expenses and Other Current Liabilities (Detail) - USD ($) $ in Thousands	Mar. 31, 2019	Dec. 31, 2018
Payables and Accruals [Abstract]
Accrued external research and development expenses	$ 2,108	$ 2,619
Accrued payroll and related expenses	1,038	2,526
Accrued professional fees	740	787
Deferred rent, current portion	601	71
Accrued leasehold improvements	190	501
Accrued other	233	423
Total	$ 4,910	$ 6,927

Stock-Based Awards - Additional

Stock-Based Awards - Additional Information (Detail) $ / shares in Units, $ in Millions	3 Months Ended
	Mar. 31, 2019USD ($)$ / sharesshares
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Total unrecognized stock-based compensation expense | $	$ 20.3
Period for recognition of unrecognized expense	2 years 7 months 6 days
Employees [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Share-based compensation arrangement by share-based payment award, options, grants in period, gross	1,301,685
Weighted average fair value of stock options granted | $ / shares	$ 5.04
2018 Stock Option and Incentive Plan [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Common stock available for issuance	2,786,567

Stock-Based Awards - Schedule o

Stock-Based Awards - Schedule of Stock Based Compensation Expense (Detail) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2019	Mar. 31, 2018
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items]
Stock based compensation expense	$ 2,577	$ 1,425
Research and Development Expenses [Member]
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items]
Stock based compensation expense	1,256	891
General and Administrative Expenses [Member]
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items]
Stock based compensation expense	$ 1,321	$ 534

Net Loss per Share - Schedule o

Net Loss per Share - Schedule of Basic and Diluted Net Loss Per Share Attributable to Common Stockholders (Detail) - USD ($) $ / shares in Units, $ in Thousands	3 Months Ended		12 Months Ended
	Mar. 31, 2019	Mar. 31, 2018	Dec. 31, 2018
Numerator:
Net loss	$ (14,834)	$ (11,161)	$ (57,500)
Net loss attributable to common stockholders	$ (14,834)	$ (11,161)
Denominator:
Weighted average common shares outstanding, basic and diluted	33,422,278	2,466,353
Net loss per share attributable to common stockholders, basic and diluted	$ (0.44)	$ (4.53)

Net Loss Per Share - Schedule_2

Net Loss Per Share - Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share (Detail) - shares	3 Months Ended
	Mar. 31, 2019	Mar. 31, 2018
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Anti-dilutive securities excluded from computation of earnings per share, amount	5,494,971	22,246,831
Redeemable Convertible Preferred Stock [Member]
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Anti-dilutive securities excluded from computation of earnings per share, amount		19,032,066
Stock Option [Member]
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Anti-dilutive securities excluded from computation of earnings per share, amount	4,670,165	1,386,577
Restricted Stock [Member]
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Anti-dilutive securities excluded from computation of earnings per share, amount	824,806	1,828,188

Commitments and Contingencies -

Commitments and Contingencies - Additional Information (Detail)	1 Months Ended			3 Months Ended			12 Months Ended
	May 31, 2018USD ($)ft²	Apr. 30, 2017USD ($)shares	Nov. 30, 2016USD ($)shares	Mar. 31, 2019USD ($)Milestoneshares	Dec. 31, 2018USD ($)ft²Subleaseshares	Mar. 31, 2018USD ($)	Dec. 31, 2017USD ($)	Dec. 31, 2016USD ($)
Other Commitments [Line Items]
Square feet of property subject to sublease | ft²	69,000
Sublease commencement period				2018-06
Sublease expiration period				2028-02
Property sublease, description				In May 2018, the Company entered into a sublease for up to approximately 69,000 square feet of office and laboratory space in Cambridge, Massachusetts. The sublease is subject and subordinate to a prime lease between the sublandlord and the prime landlord. The term of the sublease commenced in June 2018 and expires in February 2028. The sublandlord has the right to terminate the sublease after five years.
Sublease termination period	5 years
Long-term deferred rent				$ 5,769,000	$ 1,246,000
Deferred rent, current portion				601,000	$ 71,000
Rent expense				1,500,000		$ 300,000
Research and development expense				$ 10,537,000		7,849,000
Common stock issued | shares				34,406,781	34,327,554
Redeemable convertible preferred stock issued | shares				0	0
Prepaid Expenses and Other Current Assets [Member]
Other Commitments [Line Items]
Tenant improvement allowance				$ 5,500,000	$ 700,000
Maximum [Member] | Prepaid Expenses and Other Current Assets [Member]
Other Commitments [Line Items]
Tenant improvement allowance				$ 5,500,000
Sublease Agreement [Member]
Other Commitments [Line Items]
Square feet of property subject to sublease | ft²					27,000
Rental payments receivable					$ 4,500,000
Lease agreement maturity period					2 years
Number of Sub-sublease | Sublease					2
License Agreement with Novartis International Pharmaceutical Ltd. [Member]
Other Commitments [Line Items]
Fair value of shares as of issuance date							$ 9,300,000
Number of milestones met | Milestone				0
License Agreement with Novartis International Pharmaceutical Ltd. [Member] | Achievement of Clinical and Regulatory Milestones [Member] | Maximum [Member]
Other Commitments [Line Items]
Payment obligation		$ 177,000,000
License Agreement with Novartis International Pharmaceutical Ltd. [Member] | Achievement of Commercial Milestones [Member] | Maximum [Member]
Other Commitments [Line Items]
Payment obligation		$ 125,000,000
License Agreement with Novartis International Pharmaceutical Ltd. [Member] | Sales Revenue, Net [Member] | Product Concentration Risk [Member] | Maximum [Member]
Other Commitments [Line Items]
Maximum percentage of net sales of products licensed		20.00%
License Agreement with Novartis International Pharmaceutical Ltd. [Member] | Series A- Redeemable Convertible Preferred Stock [Member]
Other Commitments [Line Items]
Redeemable convertible preferred stock issued | shares		2,500,000
License Agreement with Novartis International Pharmaceutical Ltd. [Member] | Series B Redeemable Convertible Preferred Stock [Member]
Other Commitments [Line Items]
Redeemable convertible preferred stock issued | shares		643,550
Collaboration Agreement [Member]
Other Commitments [Line Items]
Research and development expense				$ 400,000		700,000
Collaboration Agreement [Member] | Development, Regulatory and Commercial Milestone [Member] | Maximum [Member]
Other Commitments [Line Items]
Payment obligation						$ 83,500,000
License Agreement With Harvard [Member]
Other Commitments [Line Items]
Research and development expense				$ 100,000
Payment of upfront fee			$ 100,000
Common stock issued | shares			385,063
Fair value of shares as of issuance date								$ 300,000
License Agreement With Harvard [Member] | Maintenance [Member] | Annually Through 2019 [Member] | Maximum [Member]
Other Commitments [Line Items]
Payment obligation			$ 100,000
License Agreement With Harvard [Member] | Maintenance [Member] | Annually Thereafter [Member]
Other Commitments [Line Items]
Payment obligation			100,000
License Agreement With Harvard [Member] | Achievement of Development and Regulatory Milestones [Member] | Maximum [Member]
Other Commitments [Line Items]
Payment obligation			7,400,000
License Agreement With Harvard [Member] | Patents [Member]
Other Commitments [Line Items]
Reimbursed costs			$ 300,000
Letter of Credit [Member]
Other Commitments [Line Items]
Cash balance to secure letter of credit associated with sublease	$ 1,800,000

Commitments and Contingencies_2

Commitments and Contingencies - Schedule of Future Minimum Lease Payments Due Under Noncancelable Operating Lease (Detail) $ in Thousands	Mar. 31, 2019USD ($)
Operating Leased Assets [Line Items]
Remainder of 2019 (nine months)	$ 4,169
2020	5,782
2021	6,072
2022	6,375
2023	6,734
Thereafter	32,000
Operating leases future minimum payments due	$ 61,132

Related Parties - Additional In

Related Parties - Additional Information (Detail) - Match Bio Therapies [Member] - USD ($)	3 Months Ended
	Mar. 31, 2019	Mar. 31, 2018
Related Party Transaction [Line Items]
Expenses paid to related party	$ 400,000	$ 200,000
Accounts Payable, Accrued Expenses and Other Current Liabilities [Member]
Related Party Transaction [Line Items]
Amounts owed to related party		400,000
Research and Development Expenses [Member]
Related Party Transaction [Line Items]
Research and development expense		200,000
Maximum [Member]
Related Party Transaction [Line Items]
Administrative expenses related party	100,000	$ 100,000
Maximum [Member] | Accounts Payable, Accrued Expenses and Other Current Liabilities [Member]
Related Party Transaction [Line Items]
Amounts owed to related party	100,000
Maximum [Member] | Research and Development Expenses [Member]
Related Party Transaction [Line Items]
Research and development expense	$ 100,000

Subsequent Event - Additional I

Subsequent Event - Additional Information (Detail) - USD ($) $ / shares in Units, $ in Millions	1 Months Ended
	May 31, 2019	Mar. 31, 2019	Dec. 31, 2018
Subsequent Event [Line Items]
Stock issued, shares		34,406,781	34,327,554
Stock issued, price per shares		$ 0.001	$ 0.001
Subsequent Event [Member]
Subsequent Event [Line Items]
Stock issued, shares	4,887,500
Stock issued, price per shares	$ 13.25
Net proceeds from common stock	$ 60.9