| Document and Entity Information | May 30, 2023 |
| Cover [Abstract] | |
| Amendment Flag | false |
| Entity Central Index Key | 0001694665 |
| Document Type | 8-K |
| Document Period End Date | May 30, 2023 |
| Entity Registrant Name | EVELO BIOSCIENCES, INC. |
| Entity Incorporation State Country Code | DE |
| Entity File Number | 001-38473 |
| Entity Tax Identification Number | 46-5594527 |
| Entity Address, Address Line One | 620 Memorial Drive |
| Entity Address, City or Town | Cambridge |
| Entity Address, State or Province | MA |
| Entity Address, Postal Zip Code | 02139 |
| City Area Code | (617) |
| Local Phone Number | 577-0300 |
| Written Communications | false |
| Soliciting Material | false |
| Pre Commencement Tender Offer | false |
| Pre Commencement Issuer Tender Offer | false |
| Security 12b Title | Common Stock, $0.001 par value per share |
| Trading Symbol | EVLO |
| Security Exchange Name | NASDAQ |
| Entity Emerging Growth Company | true |
| Entity Ex Transition Period | false |
