1 | Names of Reporting Persons
Foresite Capital Fund IV, L.P. |
2 | Check the appropriate box if a member of a Group (see
instructions)

(a) 
(b) |
3 | Sec Use Only |
4 | Citizenship or Place of Organization
DELAWARE |
Number of Shares Beneficially Owned by Each
Reporting Person With: | 5 | Sole Voting Power
8,325,000.00 | 6 | Shared Voting Power
0.00 | 7 | Sole Dispositive Power
8,325,000.00 | 8 | Shared Dispositive Power
0.00 |
|
9 | Aggregate Amount Beneficially Owned by Each Reporting
Person
8,325,000.00 |
10 | Check box if the aggregate amount in row (9) excludes
certain shares (See Instructions)
 |
11 | Percent of class represented by amount in row (9)
2.9 % |
12 | Type of Reporting Person (See Instructions)
PN |
Comment for Type of Reporting Person:
Note to Row 5: 8,325,000 shares, except that Foresite Capital Management IV, LLC ("FCM IV"), the general partner of Foresite Capital Fund IV, L.P. ("FCF IV"), may be deemed to have sole power to vote these shares, and James Tananbaum ("Tananbaum"), the managing member of FCM IV, may be deemed to have sole power to vote these shares.
Note to row 6: See response to row 5.
Note to Row 7: 8,325,000 shares, except that FCM IV, the general partner of FCF IV, may be deemed to have sole power to dispose of these shares, and Tananbaum, the managing member of FCM IV, may be deemed to have sole power to dispose of these shares.
Note to row 8: See response to row 7.
Note to Row 11: This percentage is calculated based upon 292,161,656 Common Stock outstanding of Lyell Immunopharma, Inc. (the "Issuer") as of November 26, 2024, as set forth in the Issuer's prospectus on Form 424(b)(5) filed with the Securities and Exchange Commission on December 9, 2024.
1 | Names of Reporting Persons
Foresite Capital Management IV, LLC |
2 | Check the appropriate box if a member of a Group (see
instructions)

(a) 
(b) |
3 | Sec Use Only |
4 | Citizenship or Place of Organization
DELAWARE |
Number of Shares Beneficially Owned by Each
Reporting Person With: | 5 | Sole Voting Power
8,325,000.00 | 6 | Shared Voting Power
0.00 | 7 | Sole Dispositive Power
8,325,000.00 | 8 | Shared Dispositive Power
0.00 |
|
9 | Aggregate Amount Beneficially Owned by Each Reporting
Person
8,325,000.00 |
10 | Check box if the aggregate amount in row (9) excludes
certain shares (See Instructions)
 |
11 | Percent of class represented by amount in row (9)
2.9 % |
12 | Type of Reporting Person (See Instructions)
OO |
Comment for Type of Reporting Person:
Note to Row 5: 8,325,000 shares, all of which are directly owned by FCF IV. FCM IV, the general partner of FCF IV, may be deemed to have sole power to vote these shares, and Tananbaum, the managing member of FCM IV, may be deemed to have sole power to vote these shares.
Note to row 6: See response to row 5.
Note to Row 7: 8,325,000 shares, all of which are directly owned by FCF IV. FCM IV, the general partner of FCF IV, may be deemed to have sole power to dispose of these shares, and Tananbaum, the managing member of FCM IV, may be deemed to have sole power to dispose of these shares.
Note to row 8: See response to row 7.
Note to Row 11: This percentage is calculated based upon 292,161,656 Common Stock outstanding of the Issuer as of November 26, 2024, as set forth in the Issuer's prospectus on Form 424(b)(5) filed with the Securities and Exchange Commission on December 9, 2024.
1 | Names of Reporting Persons
Foresite Capital Fund V, L.P. |
2 | Check the appropriate box if a member of a Group (see
instructions)

(a) 
(b) |
3 | Sec Use Only |
4 | Citizenship or Place of Organization
DELAWARE |
Number of Shares Beneficially Owned by Each
Reporting Person With: | 5 | Sole Voting Power
8,133,047.00 | 6 | Shared Voting Power
0.00 | 7 | Sole Dispositive Power
8,133,047.00 | 8 | Shared Dispositive Power
0.00 |
|
9 | Aggregate Amount Beneficially Owned by Each Reporting
Person
8,133,047.00 |
10 | Check box if the aggregate amount in row (9) excludes
certain shares (See Instructions)
 |
11 | Percent of class represented by amount in row (9)
2.8 % |
12 | Type of Reporting Person (See Instructions)
PN |
Comment for Type of Reporting Person:
Note to Row 5: 8,133,047 shares, except that Foresite Capital Management V, LLC ("FCM V"), the general partner of Foresite Capital Fund V, L.P. ("FCF V"), may be deemed to have sole power to vote these shares, and Tananbaum, the managing member of FCM V, may be deemed to have sole power to vote these shares.
Note to row 6: See response to row 5.
Note to Row 7: 8,133,047 shares, except that FCM V, the general partner of FCF V, may be deemed to have sole power to dispose of these shares, and Tananbaum, the managing member of FCM V, may be deemed to have sole power to dispose of these shares.
Note to row 8: See response to row 7.
Note to Row 11: This percentage is calculated based upon 292,161,656 Common Stock outstanding of the Issuer as of November 26, 2024, as set forth in the Issuer's prospectus on Form 424(b)(5) filed with the Securities and Exchange Commission on December 9, 2024.
1 | Names of Reporting Persons
Foresite Capital Management V, LLC |
2 | Check the appropriate box if a member of a Group (see
instructions)

(a) 
(b) |
3 | Sec Use Only |
4 | Citizenship or Place of Organization
DELAWARE |
Number of Shares Beneficially Owned by Each
Reporting Person With: | 5 | Sole Voting Power
8,133,047.00 | 6 | Shared Voting Power
0.00 | 7 | Sole Dispositive Power
8,133,047.00 | 8 | Shared Dispositive Power
0.00 |
|
9 | Aggregate Amount Beneficially Owned by Each Reporting
Person
8,133,047.00 |
10 | Check box if the aggregate amount in row (9) excludes
certain shares (See Instructions)
 |
11 | Percent of class represented by amount in row (9)
2.8 % |
12 | Type of Reporting Person (See Instructions)
OO |
Comment for Type of Reporting Person:
Note to Row 5: 8,133,047 shares, all of which are directly owned by FCF V. FCM V, the general partner of FCF V, may be deemed to have sole power to vote these shares, and Tananbaum, the managing member of FCM V, may be deemed to have sole power to vote these shares.
Note to row 6: See response to row 5.
Note to Row 7: 8,133,047 shares, all of which are directly owned by FCF V. FCM V, the general partner of FCF V, may be deemed to have sole power to dispose of these shares, and Tananbaum, the managing member of FCM V, may be deemed to have sole power to dispose of these shares.
Note to row 8: See response to row 7.
Note to Row 11: This percentage is calculated based upon 292,161,656 Common Stock outstanding of the Issuer as of November 26, 2024, as set forth in the Issuer's prospectus on Form 424(b)(5) filed with the Securities and Exchange Commission on December 9, 2024.
1 | Names of Reporting Persons
Foresite Capital Opportunity Fund V, L.P. |
2 | Check the appropriate box if a member of a Group (see
instructions)

(a) 
(b) |
3 | Sec Use Only |
4 | Citizenship or Place of Organization
DELAWARE |
Number of Shares Beneficially Owned by Each
Reporting Person With: | 5 | Sole Voting Power
3,020,846.00 | 6 | Shared Voting Power
0.00 | 7 | Sole Dispositive Power
3,020,846.00 | 8 | Shared Dispositive Power
0.00 |
|
9 | Aggregate Amount Beneficially Owned by Each Reporting
Person
3,020,846.00 |
10 | Check box if the aggregate amount in row (9) excludes
certain shares (See Instructions)
 |
11 | Percent of class represented by amount in row (9)
1.0 % |
12 | Type of Reporting Person (See Instructions)
PN |
Comment for Type of Reporting Person:
Note to Row 5: 3,020,846 shares, except that Foresite Capital Opportunity Management V, LLC ("FCM Opp V"), the general partner of Foresite Capital Opportunity Fund V, L.P. ("FCF Opp V"), may be deemed to have sole power to vote these shares, and Tananbaum, the managing member of FCM Opp V, may be deemed to have sole power to vote these shares.
Note to row 6: See response to row 5.
Note to Row 7: 3,020,846 shares, except that FCM Opp V, the general partner of FCF Opp V, may be deemed to have sole power to dispose of these shares, and Tananbaum, the managing member of FCM Opp V, may be deemed to have sole power to dispose of these shares.
Note to row 8: See response to row 7.
Note to Row 11: This percentage is calculated based upon 292,161,656 Common Stock outstanding of the Issuer as of November 26, 2024, as set forth in the Issuer's prospectus on Form 424(b)(5) filed with the Securities and Exchange Commission on December 9, 2024.
1 | Names of Reporting Persons
Foresite Capital Opportunity Management V, LLC |
2 | Check the appropriate box if a member of a Group (see
instructions)

(a) 
(b) |
3 | Sec Use Only |
4 | Citizenship or Place of Organization
DELAWARE |
Number of Shares Beneficially Owned by Each
Reporting Person With: | 5 | Sole Voting Power
3,020,846.00 | 6 | Shared Voting Power
0.00 | 7 | Sole Dispositive Power
3,020,846.00 | 8 | Shared Dispositive Power
0.00 |
|
9 | Aggregate Amount Beneficially Owned by Each Reporting
Person
3,020,846.00 |
10 | Check box if the aggregate amount in row (9) excludes
certain shares (See Instructions)
 |
11 | Percent of class represented by amount in row (9)
1.0 % |
12 | Type of Reporting Person (See Instructions)
OO |
Comment for Type of Reporting Person:
Note to Row 5: 3,020,846 shares, all of which are directly owned by FCF Opp V. FCM Opp V, the general partner of FCF Opp V, may be deemed to have sole power to vote these shares, and Tananbaum, the managing member of FCM Opp V, may be deemed to have sole power to vote these shares.
Note to row 6: See response to row 5.
Note to Row 7: 3,020,846 shares, all of which are directly owned by FCF Opp V. FCM Opp V, the general partner of FCF Opp V, may be deemed to have sole power to dispose of these shares, and Tananbaum, the managing member of FCM Opp V, may be deemed to have sole power to dispose of these shares.
Note to row 8: See response to row 7.
Note to Row 11: This percentage is calculated based upon 292,161,656 Common Stock outstanding of the Issuer as of November 26, 2024, as set forth in the Issuer's prospectus on Form 424(b)(5) filed with the Securities and Exchange Commission on December 9, 2024.
1 | Names of Reporting Persons
James Tananbaum |
2 | Check the appropriate box if a member of a Group (see
instructions)

(a) 
(b) |
3 | Sec Use Only |
4 | Citizenship or Place of Organization
UNITED STATES |
Number of Shares Beneficially Owned by Each
Reporting Person With: | 5 | Sole Voting Power
19,478,893.00 | 6 | Shared Voting Power
0.00 | 7 | Sole Dispositive Power
19,478,893.00 | 8 | Shared Dispositive Power
0.00 |
|
9 | Aggregate Amount Beneficially Owned by Each Reporting
Person
19,478,893.00 |
10 | Check box if the aggregate amount in row (9) excludes
certain shares (See Instructions)
 |
11 | Percent of class represented by amount in row (9)
6.7 % |
12 | Type of Reporting Person (See Instructions)
IN |
Comment for Type of Reporting Person:
Note to Row 5: 19,478,893 shares, of which 8,325,000 shares are directly owned by FCF IV, 8,133,047 shares are directly owned by FCF V and 3,020,846 shares are directly owned by FCF Opp V. Tananbaum is the managing member of each of FCM IV, which is the general partner of FCF IV, FCM V, which is the general partner of FCF V and FCM Opp V, which is the general partner of FCF Opp V. Tananbaum may be deemed to have sole power to vote these shares.
Note to row 6: See response to row 5.
Note to Row 7: 19,478,893 shares, of which 8,325,000 shares are directly owned by FCF IV, 8,133,047 shares are directly owned by FCF V and 3,020,846 shares are directly owned by FCF Opp V. Tananbaum is the managing member of each of FCM IV, which is the general partner of FCF IV, FCM V, which is the general partner of FCF V and FCM Opp V, which is the general partner of FCF Opp V. Tananbaum may be deemed to have sole power to dispose of these shares.
Note to row 8: See response to row 7.
Note to Row 11: This percentage is calculated based upon 292,161,656 Common Stock outstanding of the Issuer as of November 26, 2024, as set forth in the Issuer's prospectus on Form 424(b)(5) filed with the Securities and Exchange Commission on December 9, 2024.