Exhibit 5.1

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February 18, 2025 Solid Biosciences Inc. 500 Rutherford Avenue, 3rd Floor | | +1 617 526 6000 (t) +1 617 526 5000 (f) wilmerhale.com |
Charlestown, Massachusetts 02129
RE: Prospectus Supplement to Registration Statement on Form S-3
Ladies and Gentlemen:
This opinion is furnished to you in connection with (i) the Registration Statement on Form S-3 (File No. 333-277871) (the “Registration Statement”) filed by Solid Biosciences Inc., a Delaware corporation (the “Company”), with the Securities and Exchange Commission (the “Commission”) under the Securities Act of 1933, as amended (the “Securities Act”), for the registration of, among other things, shares of the Company’s common stock, $0.001 par value per share (the “Common Stock”), which may be issued from time to time on a delayed or continuous basis pursuant to Rule 415 under the Securities Act at an initial aggregate offering price not to exceed $300,000,000, as set forth in the Registration Statement, the base prospectus contained therein (the “Base Prospectus”) and any amendments or supplements thereto; and (ii) the prospectus supplement, dated February 18, 2025 (the “Prospectus Supplement” and, together with the Base Prospectus, the “Prospectus”), relating to the issuance and sale by the Company pursuant to the Registration Statement of (a) up to 35,739,810 shares of Common Stock, (the “Shares”) and (b) pre-funded warrants (the “Warrants”) to purchase up to 13,888,340 shares of Common Stock (the “Warrant Shares”). The Shares and the Warrants are collectively referred to herein as the “Securities.”
The Securities are to be issued and sold by the Company pursuant to the underwriting agreement, dated as of February 18, 2025 (the “Underwriting Agreement”), by and among the Company and the several underwriters named on Schedule 1 thereto, for whom Jefferies LLC and Leerink Partners LLC are acting as representatives, the form of which is filed as Exhibit 1.1 to the Company’s Current Report on Form 8-K, filed on the date hereof.
We are acting as counsel for the Company in connection with the issue and sale by the Company of the Securities. We have examined and relied upon a signed copy of the Registration Statement and the Prospectus, each as filed with the Commission. We have also examined and relied upon the Underwriting Agreement, the form of Warrant, minutes of meetings of the stockholders and the Board of Directors of the Company, including the committees thereof, as provided to us by the Company, the Certificate of Incorporation and Bylaws of the Company, each as restated and/or amended to date, and such other documents as we have deemed necessary for purposes of rendering the opinions hereinafter set forth.
