NuCana (NCNA) 6-K NuCana Announces Appointment of Cyrille Leperlier to its Board of Directors

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM 6-K

REPORT OF FOREIGN ISSUER

PURSUANT TO RULE13a-16 OR15d-16

OF THE SECURITIES EXCHANGE ACT OF 1934

For the month of May 2018

(Commission FileNo. 001-38215)

NUCANA PLC

(Translation of registrant’s name into English)

3 Lochside Way

Edinburgh EH12 9DT

United Kingdom

(Address of registrant’s principal executive office)

Indicate by check mark whether the registrant files or will file annual reports under coverForm 20-F orForm 40-F.

Form 20-F  ☒                 Form40-F  ☐

Indicate by check mark if the registrant is submitting theForm 6-K in paper as permitted by RegulationS-T Rule 101 (b) (1):  ☐

Indicate by check mark if the registrant is submitting theForm 6-K in paper as permitted by RegulationS-T Rule 101 (b) (7):  ☐

Other Events

On May 21, 2018, NuCana plc (the “Company”) issued a press release announcing the appointment of Cyrille Leperlier to the Company’s Board of Directors. The press release is attached as Exhibit 99.1 and is incorporated by reference herein.

Exhibits

99.1 Press Release dated May 21, 2018

SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized.

NuCana plc
By:	/s/ Hugh S. Griffith
Name:	Hugh S. Griffith
Title:	Chief Executive Officer

Date: May 21, 2018