INmune Bio (INMB) 10-Q 3 Nov 21 2021 Q3 Quarterly report Financial data

Document And Entity Information

Document And Entity Information - shares	9 Months Ended
	Sep. 30, 2021	Nov. 03, 2021
Document Information Line Items
Entity Registrant Name	INMUNE BIO INC.
Trading Symbol	INMB
Document Type	10-Q
Current Fiscal Year End Date	--12-31
Entity Common Stock, Shares Outstanding		17,843,303
Amendment Flag	false
Entity Central Index Key	0001711754
Entity Current Reporting Status	Yes
Entity Filer Category	Non-accelerated Filer
Document Period End Date	Sep. 30, 2021
Document Fiscal Year Focus	2021
Document Fiscal Period Focus	Q3
Entity Small Business	true
Entity Emerging Growth Company	true
Entity Shell Company	false
Entity Ex Transition Period	false
Document Quarterly Report	true
Document Transition Report	false
Entity Incorporation, State or Country Code	NV
Entity Tax Identification Number	47-5205835
Entity Address, Address Line One	225 NE Mizner Blvd
Entity Address, Address Line Two	Suite 640
Entity Address, City or Town	Boca Raton
Entity Address, State or Province	FL
Entity Address, Postal Zip Code	33432
City Area Code	858
Local Phone Number	964-3720
Entity Interactive Data Current	Yes
Title of 12(b) Security	Common Stock, par value $0.001 per share
Security Exchange Name	NASDAQ
Entity File Number	001-38793

Condensed Consolidated Balance

Condensed Consolidated Balance Sheets (Unaudited) - USD ($) $ in Thousands	Sep. 30, 2021	Dec. 31, 2020
CURRENT ASSETS
Cash and cash equivalents	$ 84,471	$ 21,967
Research and development tax credit receivable	4,958	1,686
Other tax receivable	188	113
Prepaid expenses	1,300	220
Prepaid expenses – related party	14
TOTAL CURRENT ASSETS	90,931	23,986
Operating lease – right of use asset – related party	128	156
Other assets	99
Acquired in-process research and development intangible assets	16,514	16,514
TOTAL ASSETS	107,672	40,656
CURRENT LIABILITIES
Accounts payable and accrued liabilities	4,221	1,518
Accounts payable and accrued liabilities – related parties	10	34
Deferred liabilities	541	190
Operating lease, current liability – related party	38	34
TOTAL CURRENT LIABILITIES	4,810	1,776
Long-term debt, less debt discount	14,401
Long-term operating lease liability – related party	95	126
Accrued liabilities – long-term	111
TOTAL LIABILITIES	19,417	1,902
COMMITMENTS AND CONTINGENCIES (Note 10)
STOCKHOLDERS’ EQUITY
Preferred stock, $0.001 par value, 10,000,000 shares authorized, 0 shares issued and outstanding
Common stock, $0.001 par value, 200,000,000 shares authorized, 17,843,303 and 13,481,283 shares issued and outstanding, respectively	18	13
Additional paid-in capital	142,399	72,105
Accumulated other comprehensive (loss) income	(118)	11
Accumulated deficit	(54,044)	(33,375)
TOTAL STOCKHOLDERS’ EQUITY	88,255	38,754
TOTAL LIABILITIES AND STOCKHOLDERS’ EQUITY	$ 107,672	$ 40,656

Condensed Consolidated Balanc_2

Condensed Consolidated Balance Sheets (Unaudited) (Parentheticals) - $ / shares	Sep. 30, 2021	Dec. 31, 2020
Statement of Financial Position [Abstract]
Preferred stock par value (in Dollars per share)	$ 0.001	$ 0.001
Preferred stock, shares authorized	10,000,000	10,000,000
Preferred stock, shares issued	0	0
Preferred stock, shares outstanding	0	0
Common stock par value (in Dollars per share)	$ 0.001	$ 0.001
Common stock, shares authorized	200,000,000	200,000,000
Common stock, shares issued	17,843,303	13,481,283
Common stock, shares outstanding	17,843,303	13,481,283

Condensed Consolidated Statemen

Condensed Consolidated Statements of Operations and Comprehensive Loss (Unaudited) - USD ($)	3 Months Ended		9 Months Ended
	Sep. 30, 2021	Sep. 30, 2020	Sep. 30, 2021	Sep. 30, 2020
Income Statement [Abstract]
REVENUE	$ 14,000		$ 18,000
OPERATING EXPENSES
General and administrative	2,515,000	2,457,000	6,666,000	4,960,000
Research and development	6,520,000	2,363,000	13,475,000	4,059,000
Total operating expenses	9,035,000	4,820,000	20,141,000	9,019,000
LOSS FROM OPERATIONS	(9,021,000)	(4,820,000)	(20,123,000)	(9,019,000)
OTHER (EXPENSE) INCOME	(437,000)	103,000	(546,000)	124,000
NET LOSS	$ (9,458,000)	$ (4,717,000)	$ (20,669,000)	$ (8,895,000)
Net loss per common share – basic and diluted (in Dollars per share)	$ (0.55)	$ (0.36)	$ (1.33)	$ (0.77)
Weighted average common shares outstanding - basic and diluted (in Shares)	17,329,379	12,926,539	15,553,344	11,496,753
COMPREHENSIVE LOSS
Net loss	$ (9,458,000)	$ (4,717,000)	$ (20,669,000)	$ (8,895,000)
Other comprehensive loss - foreign currency translation	(68,000)	(47,000)	(129,000)	(29,000)
Total comprehensive loss	$ (9,526,000)	$ (4,764,000)	$ (20,798,000)	$ (8,924,000)

Condensed Consolidated Statem_2

Condensed Consolidated Statement of Changes in Stockholders’ Equity (Unaudited) - USD ($) $ in Thousands	Common Stock	Additional Paid-In Capital	Accumulated Other Comprehensive Income (Loss)	Accumulated Deficit	Common Stock Issuable	Total
Balance at Dec. 31, 2019	$ 11	$ 44,834	$ (9)	$ (21,276)	$ 50	$ 23,610
Balance (in Shares) at Dec. 31, 2019	10,770,948
Issuance of common stock and warrants for cash, net		1,003				1,003
Issuance of common stock and warrants for cash, net (in Shares)	196,000
Acquisition and retirement of common stock		(1,012)				(1,012)
Acquisition and retirement of common stock (in Shares)	(220,000)
Capital contribution		216				216
Stock-based compensation		682				682
Gain on foreign currency translation			(21)			(21)
Net loss				(2,070)		(2,070)
Balance at Mar. 31, 2020	$ 11	45,723	(30)	(23,346)	50	22,408
Balance (in Shares) at Mar. 31, 2020	10,746,948
Issuance of common stock for cash		664				664
Issuance of common stock for cash (in Shares)	150,682
Stock-based compensation		681				681
Gain on foreign currency translation			39			39
Net loss				(2,108)		(2,108)
Balance at Jun. 30, 2020	$ 11	47,068	9	(25,454)	50	21,684
Balance (in Shares) at Jun. 30, 2020	10,897,630
Issuance of common stock for cash	$ 2	23,238				23,240
Issuance of common stock for cash (in Shares)	2,527,918
Cashless exercise of warrants
Cashless exercise of warrants (in Shares)	2,400
Stock-based compensation		1,046				1,046
Stock-based compensation (in Shares)	20,000
Gain on foreign currency translation			(47)			(47)
Net loss				(4,717)		(4,717)
Balance at Sep. 30, 2020	$ 13	71,352	(38)	(30,171)	$ 50	41,206
Balance (in Shares) at Sep. 30, 2020	13,447,948
Balance at Dec. 31, 2020	$ 13	72,105	11	(33,375)		38,754
Balance (in Shares) at Dec. 31, 2020	13,481,283
Issuance of common stock for cash	$ 2	28,444				28,446
Issuance of common stock for cash (in Shares)	1,439,480
Exercise of warrants for cash		18				18
Exercise of warrants for cash (in Shares)	11,875
Stock-based compensation		899				899
Gain on foreign currency translation			1			1
Net loss				(4,556)		(4,556)
Balance at Mar. 31, 2021	$ 15	101,466	12	(37,931)		63,562
Balance (in Shares) at Mar. 31, 2021	14,932,638
Stock-based compensation		769				769
Settlement of Xencor warrant for cash and common stock		(15,000)				(15,000)
Settlement of Xencor warrant for cash and common stock (in Shares)	192,533
Warrants issued to lenders as debt inducement		619				619
Gain on foreign currency translation			(62)			(62)
Net loss				(6,655)		(6,655)
Balance at Jun. 30, 2021	$ 15	87,854	(50)	(44,586)		43,233
Balance (in Shares) at Jun. 30, 2021	15,125,171
Issuance of common stock for cash	$ 3	51,804				51,807
Issuance of common stock for cash (in Shares)	2,531,374
Cashless exercise of warrants
Cashless exercise of warrants (in Shares)	3,758
Exercise of stock options		1,135				1,135
Exercise of stock options (in Shares)	183,000
Stock-based compensation		1,606				1,606
Gain on foreign currency translation			(68)			(68)
Net loss				(9,458)		(9,458)
Balance at Sep. 30, 2021	$ 18	$ 142,399	$ (118)	$ (54,044)		$ 88,255
Balance (in Shares) at Sep. 30, 2021	17,843,303

Condensed Consolidated Statem_3

Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($) $ in Thousands	9 Months Ended
	Sep. 30, 2021	Sep. 30, 2020
CASH FLOWS FROM OPERATING ACTIVITIES:
Net loss	$ (20,669)	$ (8,895)
Adjustments to reconcile net loss to net cash used in operating activities:
Stock-based compensation	3,274	2,409
Accretion of debt discount	69
Changes in operating assets and liabilities:
Research and development tax credit receivable	(3,272)	(897)
Other tax receivable	(75)	(67)
Prepaid expenses	(1,080)	(119)
Prepaid expenses – related party	(14)	26
Other assets	(99)
Accounts payable and accrued liabilities	2,703	788
Accounts payable and accrued liabilities – related parties	(24)	(65)
Deferred liabilities	351	254
Accrued liabilities – long term	111
Operating lease liability – related party	1	15
Net cash used in operating activities	(18,724)	(6,551)
CASH FLOWS FROM INVESTING ACTIVITIES:
Cash paid to Xencor to settle warrant for acquired research and development intangible assets	(15,000)
Net cash used in investing activities	(15,000)
CASH FLOWS FROM FINANCING ACTIVITIES:
Net proceeds from the issuance of debt	14,951
Net proceeds from sale of common stock	80,253	24,907
Net proceeds from exercise of stock options	1,135
Net proceeds from the exercise of warrants	18
Purchase of common stock		(1,012)
Net cash provided by financing activities	96,357	23,895
Impact on cash from foreign currency translation	(129)	(29)
NET INCREASE IN CASH	62,504	17,315
CASH AND CASH EQUIVALENTS AT BEGINNING OF PERIOD	21,967	6,996
CASH AND CASH EQUIVALENTS AT END OF PERIOD	84,471	24,311
SUPPLEMENTAL DISCLOSURE OF CASH FLOWS INFORMATION:
Cash paid for income taxes
Cash paid for interest expense	265
NONCASH INVESTING AND FINANCING ACTIVITIES:
Common stock issued to Xencor to settle warrant issued for acquired research and development intangible assets	3,300
Warrants issued to lenders as debt inducement	619
Capital contribution		$ 216

Organization and Description of

Organization and Description of Business	9 Months Ended
	Sep. 30, 2021
Accounting Policies [Abstract]
ORGANIZATION AND DESCRIPTION OF BUSINESS	NOTE 1 INmune Bio, Inc. (the “Company” or “INmune Bio”) was organized in the State of Nevada on September 25, 2015, and is a clinical stage biotechnology pharmaceutical company focused on developing and commercializing its product candidates to treat diseases where the innate immune system is not functioning normally and contributing to the patient’s disease. INmune Bio has two product platforms. The DN-TNF product platform utilizes dominant-negative technology to selectively neutralize soluble TNF, a key driver of innate immune dysfunction and mechanistic target of many diseases. DN-TNF is currently being developed for Alzheimer’s and treatment resistant depression (XPro595) and cancer (INB03). The Natural Killer Cell Priming Platform includes INKmune aimed at priming the patient’s NK cells to eliminate minimal residual disease in patients with cancer. INmune Bio’s product platforms utilize a precision medicine approach for the treatment of a wide variety of hematologic malignancies, solid tumors and chronic inflammation.

Liquidity

Liquidity	9 Months Ended
	Sep. 30, 2021
Liquidity Disclosure [Abstract]
LIQUIDITY	NOTE 2 As of September 30, 2021, the Company had an accumulated deficit of approximately $54.0 million and experienced losses since its inception. Losses have principally occurred as a result of non-cash stock-based compensation expense and the substantial resources required for research and development of the Company’s products, which included the general and administrative expenses associated with its organization and product development as well as the lack of sources of revenues until such time as the Company’s products are commercialized. To meet its current and future obligations the Company has taken the following steps to capitalize the business and achieve its business plan: ● During July 2021, the Company completed a registered direct public offering in which it sold 1,818,182 shares of common stock to investors for estimated net proceeds of $36.9 million. ● During June 2021, the Company entered into a loan and security agreement and drew down a $15.0 million term loan. ● During March 2021, the Company entered into a sales agreement with BTIG, LLC (“BTIG”), as sales agent, to establish an At-The-Market (“ATM”) offering program of up to $45 million of common stock (the “2021 ATM”), subject to certain limitations on the amount of common stock that may be offered and sold by the Company set forth in the sales agreement. The Company is required to pay BTIG a commission of 3% of the gross proceeds from the sale of shares. The Company has sold 713,192 shares of its common stock at an average price of $21.73 through the 2021 ATM for net proceeds of $14.9 million. ● During April 2020, the Company entered into a sales agreement with BTIG, as sales agent, to establish an ATM offering program to sell up to $10.0 million of the Company’s common stock (the “2020 ATM”). In August 2020, the sales agreement was amended whereby the aggregate offering was increased from $10.0 million to $30.0 million. From April 2020 through December 2020, the Company sold 178,600 shares of common stock at an average price of $5.45 per share for net proceeds of approximately $0.8 million. During the nine months ended September 30, 2021, the Company sold in aggregate 1,439,480 shares on common stock at an average price of $20.17 per share for net proceeds of $28.4 million. As of September 30, 2021, sales of our common stock pursuant to the 2020 ATM have been completed. Although it is difficult to predict the Company’s liquidity requirements, as of September 30, 2021, and based upon the Company’s current operating plan, the Company believes that it will have sufficient cash to meet its projected operating requirements for at least the next 12 months following the filing date of this Quarterly Report on Form 10-Q based on the balance of cash available as of September 30, 2021. The Company anticipates that it will continue to incur net losses for the foreseeable future as it continues the development of its clinical drug candidates and preclinical programs and incurs additional costs associated with being a public company.

Summary of Significant Accounti

Summary of Significant Accounting Policies	9 Months Ended
	Sep. 30, 2021
Accounting Policies [Abstract]
SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES	NOTE 3 Basis of Presentation The accompanying financial statements are presented in U.S. dollars and have been prepared in accordance with accounting principles generally accepted in the United States of America (“US GAAP”), and pursuant to the accounting and disclosure rules and regulations of the U.S. Securities and Exchange Commission (“SEC”). The consolidated financial statements include the accounts of INmune Bio, Inc. and its subsidiaries. Intercompany transactions and balances have been eliminated. In the opinion of management, the interim financial information includes all normal recurring adjustments necessary for a fair statement of the results for the interim periods. Risks and Uncertainties The Company is subject to risks and uncertainties as a result of the COVID-19 pandemic. The extent of the impact of the COVID-19 pandemic on the Company’s business is highly uncertain and difficult to predict. Also, economies worldwide have also been negatively impacted by the COVID-19 pandemic, however policymakers around the globe have responded with fiscal policy actions to support the healthcare industry and economy as a whole. The magnitude and overall effectiveness of these actions remain uncertain. In addition, the Company’s clinical trials have been affected by and may continue to be affected by the COVID-19 pandemic. Clinical site initiation and patient enrollment have and may continue to be delayed due to prioritization of hospital resources toward the COVID-19 pandemic. Some patients have not and others may not be able to comply with clinical trial protocols if quarantines impede patient movement or interrupt healthcare services. Similarly, the ability to recruit and retain patients and principal investigators and site staff who, as healthcare providers, may have heightened exposure to COVID-19, may adversely impact the Company’s clinical trial operations. The severity of the impact of the COVID-19 pandemic on the Company’s business will depend on a number of factors, including, but not limited to, the duration and severity of the pandemic and the extent and severity of the impact on the Company’s service providers, suppliers, contract research organizations (“CROs”) and the Company’s clinical trials, all of which are uncertain and cannot be predicted. As of the date of issuance of Company’s financial statements, the extent to which the COVID-19 pandemic may materially impact the Company’s financial condition, liquidity or results of operations is uncertain. Use of Estimates Preparing financial statements in conformity with US GAAP requires management to make estimates and assumptions that affect the reported amounts of assets, liabilities, revenue, and expenses. The Company’s significant estimates and assumptions include the valuation of stock-based compensation instruments, and the net realizable value of research and development tax credit receivables. Actual results and outcomes may differ from management’s estimates and assumptions. Cash and Cash Equivalents The Company considers all short-term, highly liquid investments with an original maturity at the date of purchase of three months or less to be cash equivalents. The Company maintains cash balances that may be uninsured or in deposit accounts that exceed Federal Deposit Insurance Corporation limits. The Company maintains its cash deposits with major financial institutions. Research and Development Tax Incentive Receivable The Company, through its wholly-owned subsidiary in Australia (“AUS”), participates in the Australian research and development tax incentive program, such that a percentage of our qualifying research and development expenditures are reimbursed by the Australian government, and such incentives are reflected as a reduction of research and development expense. The Australian research and development tax incentive is recognized when there is reasonable assurance that the incentive will be received, the relevant expenditure has been incurred and the amount of the consideration can be reliably measured. At each period end, management estimates the reimbursement available to the Company based on available information at the time. The Company, through its wholly-owned subsidiary in the United Kingdom (“UK”), participates in the research and development program provided by the United Kingdom tax relief program, such that a percentage of our qualifying research and development expenditures are reimbursed by the United Kingdom government, and such incentives are reflected as a reduction of research and development expense. The United Kingdom research and development tax incentive is recognized when there is reasonable assurance that the incentive will be received, the relevant expenditure has been incurred and the amount of the consideration can be reliably measured. At each period end, management estimates the reimbursement available to the Company based on available information at the time. Intangible Assets The Company capitalizes costs incurred in connection with in-process research and development purchased from others if the asset has alternative uses and such uses are not restricted under applicable license agreements; patent applications (principally legal fees), patent purchases, and trademarks related to its cell line as intangible assets. Acquired in-process research and development costs that do not have alternative uses are expensed as incurred. Amortization is initiated for acquired in-process research and development intangible assets when their useful lives have been determined. These acquired in-process research and development intangible assets are tested at least annually or when a triggering event occurs that could indicate a potential impairment. Basic and Diluted Loss per Share Basic loss per share is computed by dividing net loss available to common shareholders by the weighted average number of outstanding common shares during the period. Diluted loss per share gives effect to all dilutive potential common shares outstanding during the period. Dilutive loss per share excludes all potential common shares if their effect is anti-dilutive. For all periods presented, there is no difference in the number of shares used to calculate basic and diluted shares outstanding due to the Company’s net loss position. At September 30, 2021 and 2020, the Company had potentially issuable shares as follows: September 30, 2021 2020 Stock options 4,082,000 3,457,000 Warrants 93,866 1,955,922 Total 4,175,866 5,412,922 Revenue Recognition The Company recognizes revenue when the customer obtains control of promised goods or services, in an amount that reflects the consideration the Company expects to receive in exchange for those goods or services. The Company recognizes revenue following the five-step model prescribed under ASC Topic 606: (1) identify contract(s) with a customer; (2) identify the performance obligations in the contract; (3) determine the transaction price; (4) allocate the transaction price to the performance obligations in the contract; and (5) recognize revenues when (or as) the Company satisfies the performance obligations. The Company records the expenses related to revenue in research and development expense, in the periods such expenses were incurred. The Company records deferred revenues when cash payments are received or due in advance of performance, including amounts which are refundable. Stock-Based Compensation The Company utilizes the Black-Scholes option pricing model to estimate the fair value of stock option awards at the date of grant, which requires the input of highly subjective assumptions, including expected volatility and expected life. Changes in these inputs and assumptions can materially affect the measure of estimated fair value of our share-based compensation. These assumptions are subjective and generally require significant analysis and judgment to develop. When estimating fair value, some of the assumptions will be based on, or determined from, external data and other assumptions may be derived from our historical experience with stock-based payment arrangements. The appropriate weight to place on historical experience is a matter of judgment, based on relevant facts and circumstances. The Company accounts for forfeitures of stock options as they occur. Research and Development Research and development (“R&D”) costs are expensed as incurred. Research and development credits are recorded by the Company as a reduction of research and development costs. Major components of research and development costs include cash compensation, stock-based compensation, costs of preclinical studies, clinical trials and related clinical manufacturing, costs of drug development, costs of materials and supplies, facilities cost, overhead costs, regulatory and compliance costs, and fees paid to consultants and other entities that conduct certain research and development activities on the Company’s behalf. The Company recognizes grants as contra research and development expense in the consolidated statement of operations on a systematic basis over the periods in which the entity recognizes as expenses the related costs for which the grants are intended to compensate. Income Taxes The Company follows the liability method of accounting for income taxes. Under this method, deferred income tax assets and liabilities are recognized for the estimated tax consequences attributable to differences between the financial statement carrying values and their respective income tax basis (temporary differences). The effect on deferred income tax assets and liabilities of a change in tax rates is recognized in income in the period that includes the enactment date. Foreign Currency Translation The Company’s financial statements are presented in the U.S. dollar (“$”), which is the Company’s reporting currency, while its functional currencies are the U.S. Dollar for its U.S. based operations, British Pound (“GBP”) for its United Kingdom-based operations and Australian Dollars (“AUD”) for its Australian-based operations. All assets and liabilities are translated at the exchange rate on the balance sheet date, stockholders’ equity is translated at historical rates and statement of operations items are translated at the weighted average exchange rate for the period. The resulting translation adjustments are reported under other comprehensive income. Gains and losses resulting from the translations of foreign currency transactions and balances are reflected in the statement of operations and comprehensive income (loss). Recently Adopted Accounting Pronouncements There were various accounting standards and interpretations issued recently, none of which are expected to a have a material impact on the Company´s consolidated financial position, operations or cash flows. Subsequent Events The Company evaluates events that have occurred after the balance sheet date of September 30, 2021, through the date which the financial statements are issued.

Research and Development Activi

Research and Development Activity	9 Months Ended
	Sep. 30, 2021
Research and Development [Abstract]
RESEARCH AND DEVELOPMENT ACTIVITY	NOTE 4 According to UK tax law, the Company is allowed an R&D tax credit that reduces a company’s tax bill in the UK for expenses incurred in R&D subject to certain requirements. The Company’s UK subsidiary submits R&D tax credit requests annually for research and development expenses incurred. At September 30, 2021 and December 31, 2020, the Company recorded a research and development tax credit receivable in the amount of $2,942,000 and $833,000, respectively. During the nine months ended September 30, 2021 and 2020, the Company received $0 of R&D tax credit reimbursements from the UK. The UK subsidiary expects to receive R&D tax credit reimbursements during the fourth quarter of 2021. According to AUS tax law, the Company is allowed an R&D tax credit that reduces a company’s tax bill in AUS for expenses incurred in R&D subject to certain requirements. The Company’s Australian subsidiary submits R&D tax credit requests annually for research and development expenses incurred. At September 30, 2021 and December 31, 2020, the Company recorded a research and development tax credit receivable of $2,016,000 and $853,000, respectively, for R&D expenses incurred in Australia. During the nine months ended September 30, 2021 and 2020, the Company received $0 and $0.2 million, respectively, of R&D tax credit reimbursements from Australia. The Australian subsidiary received an R&D tax reimbursement of approximately $1.3 million during October 2021. Xencor, Inc. License Agreement On October 3, 2017, the Company entered into a license agreement (“Xencor License Agreement”) with Xencor, Inc. (“Xencor”), which has discovered and developed a proprietary biological molecule that inhibits soluble tumor necrosis factor. During June 2021, the Company entered into the First Amendment to License Agreement. Pursuant to the license agreement, Xencor granted the Company an exclusive worldwide, royalty-bearing license in licensed patent rights, licensed know-how and licensed materials (as defined in the license agreement) to make, develop, use, sell and import any pharmaceutical product that comprises, contains, or incorporates Xencor’s proprietary protein known as “XPro1595” that inhibits soluble tumor necrosis factor (or all modifications, formulations and variants of the licensed protein that specifically bind soluble tumor necrosis factor) alone or in combination with one or more active ingredients, in any dosage or formulation (“Licensed Products”). The Company believes the protein has numerous medical applications. Such additional alternative applications of the technology are available under the Xencor License Agreement. In connection with the Xencor License Agreement, the Company paid Xencor a one-time non-creditable and non-refundable fee of $100,000 and issued Xencor 1,585,000 shares of the Company’s common stock with a fair value of $12,221,000. In addition, the Company issued Xencor fully vested warrants with a fair value of $4,193,000 to purchase an additional number of shares of common stock equal to 10% of the fully diluted company shares immediately following such purchase. The aggregate purchase price for the full exercise of the option was $10,000,000. The Company recorded $16,514,000 for the acquisition of intangible assets for the in-process research and development as the fair value of the cash, stock and warrants on the date of the License Agreement acquisition in accordance with Accounting Standards Codification 730 – Research and Development The Company also agreed to pay Xencor a royalty on Net Sales of all Licensed Products in a given calendar year, which are payable on a country-by- country and licensed product by licensed product basis until the date that is the later of (a) the expiration of the last to expire valid claim covering such Licensed Product in such country or (b) ten years following the first sale to a third party of the licensed product in such country. Under the Xencor License Agreement, the Company also agreed to pay Xencor a percentage of any sublicensing revenue that it receives. On June 10, 2021, the Company and Xencor entered into an Option Cancellation Agreement whereby Xencor terminated its warrant to purchase 10% of the fully diluted shares of the Company in exchange for a cash payment of $15,000,000 and 192,533 shares of the Company’s common stock with a fair value of $3,300,000 based on the market price of the common stock as of June 10, 2021, which the Company issued in June 2021. The Company filed a registration statement covering the resale of these shares during September 2021 and agreed to keep the registration statement continuously effective until all such shares cease to be outstanding or otherwise cease to be registrable securities as defined in the Option Cancellation Agreement. The Company charged the cash consideration paid to Xencor to enter into the Option Cancellation Agreement to equity as the fair value of the warrant immediately prior to the Option Cancellation Agreement was greater than the consideration paid to Xencor. INKmune License Agreement On October 29, 2015, the Company entered into an exclusive license agreement (the “INKmune License Agreement”) with Immune Ventures, LLC (“Immune Ventures”). Pursuant to the INKmune License Agreement, the Company was granted exclusive worldwide rights to the patents, including rights to incorporate any improvements or additions to the patents that may be developed in the future. In consideration for the patent rights, the Company agreed to the following milestone payments: (in thousands) Each Phase I initiation $ 25 Each Phase II initiation $ 250 Each Phase III initiation $ 350 Each NDA/EMA filing $ 1,000 Each NDA/EMA awarded $ 9,000 During July 2021, the Company initiated a Phase I clinical trial using INKmune and the Company paid Immune Ventures a $25,000 milestone payment. In addition, the Company agreed to pay Immune Ventures a royalty of 1% of net sales during the life of each patent granted to the Company. RJ Tesi, the Company’s President and a member of our Board of Directors, David Moss, its Chief Financial Officer and Treasurer and Mark Lowdell, its Chief Scientific Officer, are the owners of Immune Ventures. As of September 30, 2021, no sales had occurred under this license. The term of the agreement began on October 29, 2015 and, if not terminated sooner pursuant to the agreement, ends on a country-by-country basis on the date of the expiration of the last to expire patent rights where patent rights exists. Upon the termination of the agreement, we shall have a fully paid up, perpetual, royalty-free license without further obligation to Immune Ventures. The agreement can be terminated by Immune Ventures if, after 60 days from the Company’s receipt of notice that the Company has not made a payment under the agreement, and the Company still does not make this payment. On July 20, 2018, the parties amended the agreement under which the Company was required achieve milestones pursuant to the agreement. On October 30, 2020, the parties executed an additional amendment to the agreement under which the Company is required to achieve the following milestones: Initiation of Phase II clinical trials or equivalent by October 29, 2023 Initiation of Phase III clinical trials or equivalent by October 29, 2025 Filing of NDA or equivalent by October 29, 2026 or equivalent If the Company doesn’t achieve the above milestones, it is required to negotiate in good faith with Immune Ventures to determine how it can either remedy the failure or achieve an alternate development. If the Company fails to make any required efforts, or if the efforts do not remedy the situation within 60 days of written notice by Immune Ventures, then Immune Ventures may provide notice to terminate the license or convert it to a non-exclusive license. University of Pittsburg License Agreement On October 3, 2017, the Company entered into an Assignment and Assumption Agreement with Immune Ventures related to intellectual property licensed from the University of Pittsburgh. Pursuant to the Assignment and Assumption Agreement (“Assignment Agreement”), Immune Ventures assigned all of its rights, obligations and liabilities under an Exclusive License Agreement between the University of Pittsburgh – Of the Commonwealth System of Higher Education (“Licensor”) and Immune Ventures to INmune Bio (“Licensee”), (the “PITT Agreement”). Consideration under the PITT Agreement includes: (i) annual maintenance fees, (ii) royalty payments based on the sale of products making use of the licensed technology, and (iii) milestone payments. Annual maintenance fees under the PITT Agreement include the following: (in thousands) June 26 of each year 2021-2022 $ 5 June 26 of each year 2023-2024 $ 10 June 26 of each year 2025 until first commercial sale $ 25 Upon first commercial sale of a product making use of the licensed technology under the PITT Agreement, the Licensee is required to pay royalties equal to 2.5% of Net Sales each calendar quarter. Moreover, under the PITT Agreement the Licensee is required to make milestone payments as follows: (in thousands) Each Phase I initiation $ 50 Each Phase III initiation $ 500 First commercial sale of product making use of licensed technology $ 1,250 The Company had no amounts owed pursuant to the PITT Agreement as of September 30, 2021. The PITT Agreement expires upon the earlier of: (i) expiration of the last claim of the Patent Rights (as defined in the PITT Agreement) forming the subject matter of the PITT Agreement; or (ii) the date that is 20 years from the effective date of the agreement (June 26, 2037). The Licensee may terminate the PITT Agreement upon 3 months prior written notice provided all payments under the license are current. The Licensor may terminate the PITT Agreement upon written notice if: (i) Licensee defaults as to performance of material obligations which have not been cured within 60 days after receiving written notice; or (ii) Licensee ceases to carry out its business, becomes bankrupt or insolvent, applies for or consents to the appointment of a trustee, receiver or liquidator of its assets or seeks relief under any law for the aid of debtors. University College London License Agreement – MSC On July 19, 2019, the Company entered into license agreement with UCL Business PLC (“UCLB”) with a ten (10) year term. Pursuant to the license agreement, the Company acquired an exclusive license (and a right to sub-license) to the technology and know-how relating to an isolation and commercial scale expansion methodology of GMP grade human umbilical cord mesenchymal stem/stromal cells (“MSC”). During July 2021, the Company terminated its license agreement with UCLB.

Lease

Lease	9 Months Ended
	Sep. 30, 2021
Leases [Abstract]
LEASE	NOTE 5 In May 2019, the Company signed a sublease agreement with a related party for office space in La Jolla, California. The lease has a 61-month term, which corresponds to the lease term of the lessor. The lessor is CTI Clinical Trial & Consulting Services (“CTI”). CTI is majority-owned by a member of the Company’s Board of Directors. The lessor may extend its lease for an additional 5 years, and, if it does, the Company may also extend its sublease for 5 years. The Company did not include the option to extend in the calculation of the lease liabilities as such extension is not reasonably certain to occur. Variable lease costs for the Company’s lease consists of operating expenses for the spaces. In September 2021, the Company signed a lease for office space in Boca Raton, Florida. See Note 10. Below is a summary of the Company’s right-of-use assets and liabilities as of September 30, 2021: (in thousands, except years and rate) Right-of-use asset – related party $ 128 Operating lease, current liability – related party $ 38 Long-term operating lease liability – related party 95 Total lease liability $ 133 Weighted-average remaining lease term 2.8 years Weighted-average discount rate 10.00 %

Related Party Transactions

Related Party Transactions	9 Months Ended
	Sep. 30, 2021
Related Party Transactions [Abstract]
RELATED PARTY TRANSACTIONS	NOTE 6 UCL At September 30, 2021 and December 31, 2020, the Company owed UCL Consultants Limited (“UCL”) $10,000 and $34,000, respectively, in connection with medical research performed on behalf of the Company. At September 30, 2021 and December 31, 2020, the Company recorded prepaid expenses of $14,000 and $0, respectively, for medical research to be performed on behalf of the Company by UCL. During the nine months ended September 30, 2021 and 2020, the Company paid UCL $176,000 and $335,000, respectively, for medical research performed on behalf of the Company. UCL is a wholly owned subsidiary of the University of London. The Company’s Chief Scientific and Manufacturing Officer is a professor at the University of London. CTI During the nine months ended September 30, 2021 and 2020, the Company paid CTI $0 and $127,000, respectively, for medical research performed on behalf of the Company. During the nine months ended September 30, 2020, the Company recorded a capital contribution of $216,000 for the forgiveness of certain accounts payable due to CTI. The Company had no amounts payable to CTI as of September 30, 2021 and December 31, 2020.

Debt

Debt	9 Months Ended
	Sep. 30, 2021
Debt Disclosure [Abstract]
DEBT	NOTE 7 On June 10, 2021, the Company entered into a Loan and Security Agreement (the “Term Loan”) with Silicon Valley Bank and SVB Innovation Credit Fund VIII, L.P., together (the “Lenders”). The Term Loan provides for a $15.0 million term loan, of which the Company borrowed the entire amount on June 10, 2021, and is secured by the Company’s assets. The Term Loan also provides for the Company to request an additional $5.0 million term loan from the Lenders, which may be granted or denied at the sole discretion of the Lenders. The Company paid the Lenders $47,000 to access the term loan, which has been included as a component of the debt discount and is amortized to interest expense over the term of the loan. The term loan and debt discount are as follows as of September 30, 2021: (in thousands) Term Loan $ 15,000 Less: debt discount and financing costs, net (599 ) Less: current portion - Long-term debt $ 14,401 For the three and nine months ended September 30, 2021 the Company recognized interest expense of $0.4 million and $0.5 million, respectively, related to the Term Loan. The term loan repayment schedule provided for interest only payments beginning on July 1, 2021, and continuing for 12 months, followed by monthly principal and interest payments, starting on July 1, 2022 and continuing through the maturity date of January 1, 2025. During August, the Lenders extended the interest-only period for one year due to the Company achieving an equity milestone as fully defined in the Term Loan The Term Loan includes a final payment fee equal to 6.5% of the original principal amount borrowed payable on the earlier of the repayment of the loan in full and the maturity date. The Company has the option to prepay the outstanding balance of the term loans in full, subject to a prepayment premium of (i) 3% of the original principal amount borrowed for any prepayment on or prior to the first anniversary of the loan, (ii) 2% of the original principal amount borrowed for any prepayment after the first anniversary and on or before the second anniversary of the loan or (iii) 1% of the original principal amount borrowed for any prepayment after the second anniversary of the loan but before the maturity date. The expected repayment of the $15.0 million Term loan principal is as follows as of September 30, 2021: (in thousands, except years) 2021 $ - 2022 - 2023 5,833 2024 9,167 Total debt $ 15,000 Upon the occurrence of certain events, including but not limited to the Company’s failure to satisfy its payment obligations under the Term Loan, the breach of certain of its other covenants under the Term Loan, or the occurrence of a material adverse change, the Lenders will have the right, among other remedies, to declare all principal and interest immediately due and payable, and will have the right to receive the final payment fee and, if the payment of principal and interest is due prior to maturity, the applicable prepayment fee.

Stockholders' Equity

Stockholders' Equity	9 Months Ended
	Sep. 30, 2021
Stockholders' Equity Note [Abstract]
STOCKHOLDERS’ EQUITY	NOTE 8 Lincoln Park On May 15, 2019, the Company entered into both a securities purchase agreement and registration rights agreement with Lincoln Park Capital Fund, LLC (“Lincoln Park”). Under the terms and subject to the conditions of the securities purchase agreement, the Company had the right to sell to Lincoln Park, and Lincoln Park was obligated to purchase, up to $20.0 million in shares of the Company’s common stock, subject to certain limitations, over the 24-month period that commenced on May 15, 2019. During the nine months ended September 30, 2020, the Company issued 196,000 shares of its common stock to Lincoln Park for approximately $1.0 million of cash. During April 2021, the Company terminated the securities purchase agreement with Lincoln Park. Purchase and retirement of common stock During January 2020, the Company purchased and cancelled 220,000 shares of its common stock from a shareholder in exchange for approximately $1.0 million of cash. Underwritten Stock Offering During July 2020, the Company completed an underwritten public offering in which it sold 2,500,000 shares of common stock at a public offering price of $10.00 per share. The 2,500,000 shares sold included the full exercise of the underwriters’ option to purchase 326,086 shares at a price of $10.00 per share. Aggregate net proceeds from the underwritten public offering were $23.1 million, net of $1.9 million in underwriting discounts and commissions and offering expenses. Common Stock – At the Market Offering During the nine months ended September 30, 2020, we issued and sold 178,600 shares of common stock at an average price of $5.45 per share under the 2020 ATM program. The aggregate net proceeds were approximately $0.8 million after BTIG’s commission and other offering expenses. During the nine months ended September 30, 2021, the Company sold 1,439,480 shares of its common stock at an average price of $20.17 per share under the 2020 ATM program. The aggregate net proceeds were approximately $28.4 million after BTIG’s commission and other offering expenses. During the nine months ended September 30, 2021, the Company sold 713,192 shares of its common stock at an average price of $21.73 per share under the 2021 ATM program. The aggregate net proceeds were approximately $14.9 million after BTIG’s commission and other offering expenses. Registered Direct Offering During July 2021, the Company completed a registered direct offering whereby the Company sold 1,818,182 shares of its common stock to investors for net proceeds of $36.9 million. Common Stock Issued for Services During July 2020, the Company granted a consultant 50,000 fully vested warrants with a 5-year term, of which 25,000 warrants had an exercise price of $5.50 per share and 25,000 warrants had an exercise price of $10.00 per share. The fair value of these warrants was $356,874 based on the Black-Scholes Option Pricing Model and was recorded within general and administrative expense. The assumptions used for these warrants consist of the exercise prices, expected dividends of 0%, expected volatility of 111.67% based on the trading history of similar companies, risk-free rate of 0.30% based on the applicable US Treasury bill rate and an expected life of 5.0 years. During July 2020, the Company issued the consultant 20,000 shares of common stock and cancelled the 50,000 warrants. The 20,000 shares were issued from the Company’s 2019 Incentive Stock Plan and had a fair value of approximately $230,000 based on the market value of the Company’s common stock on the grant date. The Company accounted for the exchange of the warrants for shares of common stock as a modification and recorded no additional expense in connection with the exchange as the fair value of warrants exceeded the fair value of the shares issued. Issuance of shares to Xencor On June 10, 2021, the Company and Xencor entered into an Option Cancellation Agreement whereby the Company issued 192,533 shares of its common stock to Xencor (See Note 4). Stock options During January 2021, the Company granted certain employees and directors options to purchase 198,549 shares of its common stock pursuant to the 2017 and 2019 Incentive Stock Plans. The stock options have a fair value of approximately $4.2 million that was calculated using the Black-Scholes option-pricing model. Variables used in the Black-Scholes option-pricing model include: (1) discount rate of 0.78% based on the applicable US Treasury bill rate (2) expected life of 6.0 - 6.25 years, (3) expected volatility of approximately 113% - 114% based on the trading history of similar companies, and (4) zero expected dividends. During June 2021, the Company granted certain employees and directors options to purchase 236,451 shares of its common stock pursuant to the 2021 Incentive Stock Plan. The stock options have a fair value of approximately $3.3 million that was calculated using the Black-Scholes option-pricing model. Variables used in the Black-Scholes option-pricing model include: (1) discount rate of 1.23% based on the applicable US Treasury bill rate (2) expected life of 6.0 - 6.25 years, (3) expected volatility of approximately 107% - 108% based on the trading history of similar companies, and (4) zero expected dividends. During July, August and September 2021, the Company granted certain employees and consultants options to purchase in aggregate 373,000 shares of its common stock pursuant to the 2021 Incentive Stock Plan. The stock options have a fair value of approximately $6.3 million that was calculated using the Black-Scholes option-pricing model. Variables used in the Black-Scholes option-pricing model include: (1) discount rate of 0.96% - 1.31% based on the applicable US Treasury bill rate (2) expected life of 6.0 – 10.0 years, (3) expected volatility of approximately 105% - 109% based on the trading history of similar companies, and (4) zero expected dividends. The following table summarizes stock option activity during the nine months ended September 30, 2021: (in thousands, except share and per share amounts) Number Shares Weighted- Exercise Price Weighted- Remaining Contractual Term (years) Aggregate Intrinsic Value Outstanding at January 1, 2021 3,457,000 $ 5.82 8.05 $ 39,405 Options granted 808,000 $ 20.73 10.00 - Options exercised (183,000 ) $ 6.21 - - Options cancelled - $ - - - Outstanding at September 30, 2021 4,082,000 $ 8.65 7.44 $ 45,171 Exercisable at September 30, 2021 2,578,000 $ 6.49 7.09 $ 33,395 During the nine months ended September 30, 2021 and 2020, the Company recognized stock-based compensation expense of approximately $3.3 million and $2.1 million, respectively, related to the vesting of stock options. As of September 30, 2021, there was approximately $14.6 million of total unrecognized compensation cost related to non-vested stock options which is expected to be recognized over a weighted-average period of 2.73 years. Warrants The Company issued 45,386 warrants to the Company’s lenders upon obtaining its loan in June 2021. The warrants have a 10-year term and an exercise price of $14.05. The warrants have a fair value of approximately $0.6 million that was calculated using the Black-Scholes option-pricing model. Variables used in the Black-Scholes option-pricing model include: (1) discount rate of 1.45% based on the applicable US Treasury bill rate (2) expected life of 10.0 years, (3) expected volatility of approximately 103% based on the trading history of similar companies, and (4) zero expected dividends. At September 30, 2021, the intrinsic value of these warrants is $244,000. In connection with the Company’s initial public offering in February 2019, the Company issued warrants to the placement agents to purchase the Company’s common stock at an exercise price of $9.60 per common share, which warrants are exercisable until December 19, 2023. During the nine months ended September 30, 2021, 6,147 of these warrants were exercised on a cashless basis in exchange for 3,758 shares of common stock. At September 30, 2021, 28,688 of these warrants are outstanding and the intrinsic value is $282,000. On June 30, 2017, the Company issued fully vested warrants to purchase 31,667 shares of the Company’s common stock to a third party in conjunction with the common stock sold for cash. The warrants have a $1.50 exercise price and expire on June 30, 2022. During the nine months ended September 30, 2021, 11,875 of these warrants were exercised for cash proceeds of $18,000. At September 30, 2021, 19,792 of these warrants are outstanding, with an intrinsic value of $355,000. Stock-based Compensation by Class of Expense The following summarizes the components of stock-based compensation expense in the consolidated statements of operations for the three and nine months ended September 30, 2021 and 2020 respectively: (in thousands) Three Months Three Months Nine Months Nine Months Research and development $ 705 $ 146 $ 1,090 $ 423 General and administrative 901 900 2,184 1,986 Total $ 1,606 $ 1,046 $ 3,274 $ 2,409 Shareholder Rights Agreement On December 30, 2020, the Board of Directors (the “Board”) of the Company approved and adopted a Rights Agreement, dated as of December 30, 2020, by and between the Company and VStock Transfer, LLC, as rights agent, pursuant to which the Board declared a dividend of one preferred share purchase right (each, a “Right”) for each outstanding share of the Company’s common stock held by stockholders as of the close of business on January 11, 2021. When exercisable, each right initially would represent the right to purchase from the Company one one-thousandth of a share of a newly designated series of preferred stock, Series A Junior Participating Preferred Stock, par value $0.001 per share, of the Company, at an exercise price of $300.00 per one one-thousandth of a Series A Junior Participating Preferred Share, subject to adjustment. Subject to various exceptions, the Rights become exercisable in the event any person (excluding certain exempted or grandfathered persons) becomes the beneficial owner of twenty percent or more of the Company’s common stock without the approval of the Board. The Rights are scheduled to expire on December 30, 2021.

Collaborative Agreements

Collaborative Agreements	9 Months Ended
	Sep. 30, 2021
Organization, Consolidation and Presentation of Financial Statements [Abstract]
COLLABORATIVE AGREEMENTS	NOTE 9 During 2020, the Company was awarded a $0.5 million grant from the Amyotrophic Lateral Sclerosis (“ALS”) Association to fund a study of the efficacy of XPro1595 to reverse ALS in vitro and to fund a study of the efficacy of XPro1595 to protect against ALS model phenotypes in vivo. During the nine months ended September 30, 2021 and 2020, the Company received $0.1 million and $0.3 million, respectively, of cash proceeds pursuant to this grant which the Company recorded as deferred liabilities. The Company offsets costs incurred related to this research against the grants. As of September 30, 2021 and December 31, 2020, the Company recorded approximately $0.2 million and $0.1 million, respectively, as deferred liabilities in the consolidated balance sheet related to the ALS grant. During September 2020, the Company was awarded a grant of up to $2.9 million from the National Institutes of Health (“NIH”). The grant will support a Phase 2 study of XPro1595 in patients with treatment resistant depression. As of September 30, 2021, the Company has not received any proceeds pursuant to this grant.

Commitments and Contingencies

Commitments and Contingencies	9 Months Ended
	Sep. 30, 2021
Commitments and Contingencies Disclosure [Abstract]
COMMITMENTS AND CONTINGENCIES	NOTE 10 Lease In May 2019, the Company signed a sublease agreement with a related party for office space in La Jolla, California. The lease has a 61-month term, which corresponds to the lease term of the lessor. The lessor is CTI. During September 2021, the Company signed a lease agreement with a third party for office space in Boca Raton, Florida. The lease agreement has a 64-month term and will commence during the fourth quarter of 2021. Future minimum payments pursuant to the leases are as follows: (in thousands, except years) 2021 $ 23 2022 157 2023 237 2024 220 2025 193 Thereafter 216 Total $ 1,046 During the three and nine months ended September 30, 2021, the Company recognized $19,000 and $45,000, respectively, in operating lease expense, which is included in general and administrative expenses in the Company’s consolidated statement of operations. Litigation The Company is subject to claims and suits that arise from time to time in the ordinary course of our business. Although management currently believes that resolving claims against the Company, individually or in aggregate, will not have a material adverse impact in the Company’s consolidated financial statements, these matters are subject to inherent uncertainties and management’s view of these matters may change in the future.

Accounting Policies, by Policy

Accounting Policies, by Policy (Policies)	9 Months Ended
	Sep. 30, 2021
Accounting Policies [Abstract]
Basis of Presentation	Basis of Presentation The accompanying financial statements are presented in U.S. dollars and have been prepared in accordance with accounting principles generally accepted in the United States of America (“US GAAP”), and pursuant to the accounting and disclosure rules and regulations of the U.S. Securities and Exchange Commission (“SEC”). The consolidated financial statements include the accounts of INmune Bio, Inc. and its subsidiaries. Intercompany transactions and balances have been eliminated. In the opinion of management, the interim financial information includes all normal recurring adjustments necessary for a fair statement of the results for the interim periods.
Risks and Uncertainties	Risks and Uncertainties The Company is subject to risks and uncertainties as a result of the COVID-19 pandemic. The extent of the impact of the COVID-19 pandemic on the Company’s business is highly uncertain and difficult to predict. Also, economies worldwide have also been negatively impacted by the COVID-19 pandemic, however policymakers around the globe have responded with fiscal policy actions to support the healthcare industry and economy as a whole. The magnitude and overall effectiveness of these actions remain uncertain. In addition, the Company’s clinical trials have been affected by and may continue to be affected by the COVID-19 pandemic. Clinical site initiation and patient enrollment have and may continue to be delayed due to prioritization of hospital resources toward the COVID-19 pandemic. Some patients have not and others may not be able to comply with clinical trial protocols if quarantines impede patient movement or interrupt healthcare services. Similarly, the ability to recruit and retain patients and principal investigators and site staff who, as healthcare providers, may have heightened exposure to COVID-19, may adversely impact the Company’s clinical trial operations. The severity of the impact of the COVID-19 pandemic on the Company’s business will depend on a number of factors, including, but not limited to, the duration and severity of the pandemic and the extent and severity of the impact on the Company’s service providers, suppliers, contract research organizations (“CROs”) and the Company’s clinical trials, all of which are uncertain and cannot be predicted. As of the date of issuance of Company’s financial statements, the extent to which the COVID-19 pandemic may materially impact the Company’s financial condition, liquidity or results of operations is uncertain.
Use of Estimates	Use of Estimates Preparing financial statements in conformity with US GAAP requires management to make estimates and assumptions that affect the reported amounts of assets, liabilities, revenue, and expenses. The Company’s significant estimates and assumptions include the valuation of stock-based compensation instruments, and the net realizable value of research and development tax credit receivables. Actual results and outcomes may differ from management’s estimates and assumptions.
Cash and Cash Equivalents	Cash and Cash Equivalents The Company considers all short-term, highly liquid investments with an original maturity at the date of purchase of three months or less to be cash equivalents. The Company maintains cash balances that may be uninsured or in deposit accounts that exceed Federal Deposit Insurance Corporation limits. The Company maintains its cash deposits with major financial institutions.
Research and Development Tax Incentive Receivable	Research and Development Tax Incentive Receivable The Company, through its wholly-owned subsidiary in Australia (“AUS”), participates in the Australian research and development tax incentive program, such that a percentage of our qualifying research and development expenditures are reimbursed by the Australian government, and such incentives are reflected as a reduction of research and development expense. The Australian research and development tax incentive is recognized when there is reasonable assurance that the incentive will be received, the relevant expenditure has been incurred and the amount of the consideration can be reliably measured. At each period end, management estimates the reimbursement available to the Company based on available information at the time. The Company, through its wholly-owned subsidiary in the United Kingdom (“UK”), participates in the research and development program provided by the United Kingdom tax relief program, such that a percentage of our qualifying research and development expenditures are reimbursed by the United Kingdom government, and such incentives are reflected as a reduction of research and development expense. The United Kingdom research and development tax incentive is recognized when there is reasonable assurance that the incentive will be received, the relevant expenditure has been incurred and the amount of the consideration can be reliably measured. At each period end, management estimates the reimbursement available to the Company based on available information at the time.
Intangible Assets	Intangible Assets The Company capitalizes costs incurred in connection with in-process research and development purchased from others if the asset has alternative uses and such uses are not restricted under applicable license agreements; patent applications (principally legal fees), patent purchases, and trademarks related to its cell line as intangible assets. Acquired in-process research and development costs that do not have alternative uses are expensed as incurred. Amortization is initiated for acquired in-process research and development intangible assets when their useful lives have been determined. These acquired in-process research and development intangible assets are tested at least annually or when a triggering event occurs that could indicate a potential impairment.
Basic and Diluted Loss per Share	Basic and Diluted Loss per Share Basic loss per share is computed by dividing net loss available to common shareholders by the weighted average number of outstanding common shares during the period. Diluted loss per share gives effect to all dilutive potential common shares outstanding during the period. Dilutive loss per share excludes all potential common shares if their effect is anti-dilutive. For all periods presented, there is no difference in the number of shares used to calculate basic and diluted shares outstanding due to the Company’s net loss position. At September 30, 2021 and 2020, the Company had potentially issuable shares as follows: September 30, 2021 2020 Stock options 4,082,000 3,457,000 Warrants 93,866 1,955,922 Total 4,175,866 5,412,922
Revenue Recognition	Revenue Recognition The Company recognizes revenue when the customer obtains control of promised goods or services, in an amount that reflects the consideration the Company expects to receive in exchange for those goods or services. The Company recognizes revenue following the five-step model prescribed under ASC Topic 606: (1) identify contract(s) with a customer; (2) identify the performance obligations in the contract; (3) determine the transaction price; (4) allocate the transaction price to the performance obligations in the contract; and (5) recognize revenues when (or as) the Company satisfies the performance obligations. The Company records the expenses related to revenue in research and development expense, in the periods such expenses were incurred. The Company records deferred revenues when cash payments are received or due in advance of performance, including amounts which are refundable.
Stock-Based Compensation	Stock-Based Compensation The Company utilizes the Black-Scholes option pricing model to estimate the fair value of stock option awards at the date of grant, which requires the input of highly subjective assumptions, including expected volatility and expected life. Changes in these inputs and assumptions can materially affect the measure of estimated fair value of our share-based compensation. These assumptions are subjective and generally require significant analysis and judgment to develop. When estimating fair value, some of the assumptions will be based on, or determined from, external data and other assumptions may be derived from our historical experience with stock-based payment arrangements. The appropriate weight to place on historical experience is a matter of judgment, based on relevant facts and circumstances. The Company accounts for forfeitures of stock options as they occur.
Research and Development	Research and Development Research and development (“R&D”) costs are expensed as incurred. Research and development credits are recorded by the Company as a reduction of research and development costs. Major components of research and development costs include cash compensation, stock-based compensation, costs of preclinical studies, clinical trials and related clinical manufacturing, costs of drug development, costs of materials and supplies, facilities cost, overhead costs, regulatory and compliance costs, and fees paid to consultants and other entities that conduct certain research and development activities on the Company’s behalf. The Company recognizes grants as contra research and development expense in the consolidated statement of operations on a systematic basis over the periods in which the entity recognizes as expenses the related costs for which the grants are intended to compensate.
Income Taxes	Income Taxes The Company follows the liability method of accounting for income taxes. Under this method, deferred income tax assets and liabilities are recognized for the estimated tax consequences attributable to differences between the financial statement carrying values and their respective income tax basis (temporary differences). The effect on deferred income tax assets and liabilities of a change in tax rates is recognized in income in the period that includes the enactment date.
Foreign Currency Translation	Foreign Currency Translation The Company’s financial statements are presented in the U.S. dollar (“$”), which is the Company’s reporting currency, while its functional currencies are the U.S. Dollar for its U.S. based operations, British Pound (“GBP”) for its United Kingdom-based operations and Australian Dollars (“AUD”) for its Australian-based operations. All assets and liabilities are translated at the exchange rate on the balance sheet date, stockholders’ equity is translated at historical rates and statement of operations items are translated at the weighted average exchange rate for the period. The resulting translation adjustments are reported under other comprehensive income. Gains and losses resulting from the translations of foreign currency transactions and balances are reflected in the statement of operations and comprehensive income (loss).
Recently Adopted Accounting Pronouncements	Recently Adopted Accounting Pronouncements There were various accounting standards and interpretations issued recently, none of which are expected to a have a material impact on the Company´s consolidated financial position, operations or cash flows.
Subsequent Events	Subsequent Events The Company evaluates events that have occurred after the balance sheet date of September 30, 2021, through the date which the financial statements are issued.

Summary of Significant Accoun_2

Summary of Significant Accounting Policies (Tables)	9 Months Ended
	Sep. 30, 2021
Accounting Policies [Abstract]
Schedule of potentially issuable shares	September 30, 2021 2020 Stock options 4,082,000 3,457,000 Warrants 93,866 1,955,922 Total 4,175,866 5,412,922

Research and Development Acti_2

Research and Development Activity (Tables)	9 Months Ended
	Sep. 30, 2021
Research and Development [Abstract]
Schedule of milestone payments in consideration for the patent rights	Each Phase I initiation $ 25 Each Phase II initiation $ 250 Each Phase III initiation $ 350 Each NDA/EMA filing $ 1,000 Each NDA/EMA awarded $ 9,000
Schedule of consideration of annual maintenance fees under the PITT agreement	June 26 of each year 2021-2022 $ 5 June 26 of each year 2023-2024 $ 10 June 26 of each year 2025 until first commercial sale $ 25
Schedule of licensee is required to make milestone payments	Each Phase I initiation $ 50 Each Phase III initiation $ 500 First commercial sale of product making use of licensed technology $ 1,250

Lease (Tables)

Lease (Tables)	9 Months Ended
	Sep. 30, 2021
Leases [Abstract]
Schedule of right-of-use assets and liabilities for operating lease	Right-of-use asset – related party $ 128 Operating lease, current liability – related party $ 38 Long-term operating lease liability – related party 95 Total lease liability $ 133 Weighted-average remaining lease term 2.8 years Weighted-average discount rate 10.00 %

Debt (Tables)

Debt (Tables)	9 Months Ended
	Sep. 30, 2021
Debt Disclosure [Abstract]
Schedule of term loan and debt discount	Term Loan $ 15,000 Less: debt discount and financing costs, net (599 ) Less: current portion - Long-term debt $ 14,401
Schedule of repayment term loan principal	2021 $ - 2022 - 2023 5,833 2024 9,167 Total debt $ 15,000

Stockholders' Equity (Tables)

Stockholders' Equity (Tables)	9 Months Ended
	Sep. 30, 2021
Stockholders' Equity Note [Abstract]
Schedule of stock option activity	(in thousands, except share and per share amounts) Number Shares Weighted- Exercise Price Weighted- Remaining Contractual Term (years) Aggregate Intrinsic Value Outstanding at January 1, 2021 3,457,000 $ 5.82 8.05 $ 39,405 Options granted 808,000 $ 20.73 10.00 - Options exercised (183,000 ) $ 6.21 - - Options cancelled - $ - - - Outstanding at September 30, 2021 4,082,000 $ 8.65 7.44 $ 45,171 Exercisable at September 30, 2021 2,578,000 $ 6.49 7.09 $ 33,395
Schedule of stock-based compensation expense	(in thousands) Three Months Three Months Nine Months Nine Months Research and development $ 705 $ 146 $ 1,090 $ 423 General and administrative 901 900 2,184 1,986 Total $ 1,606 $ 1,046 $ 3,274 $ 2,409

Commitments and Contingencies (

Commitments and Contingencies (Tables)	9 Months Ended
	Sep. 30, 2021
Commitments and Contingencies Disclosure [Abstract]
Schedule of future minimum payments pursuant to the lease	2021 $ 23 2022 157 2023 237 2024 220 2025 193 Thereafter 216 Total $ 1,046

Liquidity (Details)

Liquidity (Details) - USD ($) $ / shares in Units, $ in Millions	1 Months Ended						9 Months Ended
	Jul. 31, 2021	Jun. 30, 2021	Mar. 31, 2021	Aug. 31, 2020	Jul. 31, 2020	Apr. 30, 2020	Sep. 30, 2021	Dec. 31, 2020	Sep. 30, 2020
Liquidity (Details) [Line Items]
Accumulated deficit							$ 54
Sale of common stock shares (in Shares)	1,818,182		713,192		2,500,000				178,600
Offering program common stock value			$ 45
Term loan		$ 15
Gross proceeds from the sale of shares, percentage			3.00%
Average price per share (in Dollars per share)			$ 21.73
Net proceeds from common stock			$ 14.9
Sales Agreement [Member]
Liquidity (Details) [Line Items]
Sale of common stock shares (in Shares)							1,439,480	178,600
Average price per share (in Dollars per share)							$ 20.17	$ 5.45
Net proceeds from common stock								$ 0.8
Net proceeds							$ 28.4
Sales Agreement [Member] | Minimum [Member]
Liquidity (Details) [Line Items]
Aggregate offering price				$ 10
Sales Agreement [Member] | Maximum [Member]
Liquidity (Details) [Line Items]
Aggregate offering price				$ 30
Public Offering [Member]
Liquidity (Details) [Line Items]
Sale of common stock shares (in Shares)	1,818,182
Offering program common stock value	$ 36.9
ATM Offering Program [Member]
Liquidity (Details) [Line Items]
Offering program common stock value						$ 10

Summary of Significant Accoun_3

Summary of Significant Accounting Policies (Details) - Schedule of potentially issuable shares - shares	9 Months Ended
	Sep. 30, 2021	Sep. 30, 2020
Summary of Significant Accounting Policies (Details) - Schedule of potentially issuable shares [Line Items]
Total	4,175,866	5,412,922
Warrants [Member]
Summary of Significant Accounting Policies (Details) - Schedule of potentially issuable shares [Line Items]
Total	93,866	1,955,922
Stock options [Member]
Summary of Significant Accounting Policies (Details) - Schedule of potentially issuable shares [Line Items]
Total	4,082,000	3,457,000

Research and Development Acti_3

Research and Development Activity (Details) - USD ($)	Jun. 10, 2021	Oct. 31, 2021	Jul. 31, 2021	Jul. 19, 2019	Sep. 30, 2021	Sep. 30, 2020	Dec. 31, 2020
Research and Development Activity (Details) [Line Items]
Common stock issued (in Shares)	192,533				17,843,303		13,481,283
Common stock equal to fully diluted shares to purchase with fair value	10.00%
Cash payment	$ 15,000,000
Stock issued	$ 3,300,000
Business agreement term, description				On July 19, 2019, the Company entered into license agreement with UCL Business PLC (“UCLB”) with a ten (10) year term.
Xencor, Inc. License Agreement [Member]
Research and Development Activity (Details) [Line Items]
Non refundable fee					$ 100,000
Common stock issued (in Shares)					1,585,000
Common stock with fair value on discounted cash flow					$ 12,221,000
Fair value of warrants					$ 4,193,000
Common stock equal to fully diluted shares to purchase with fair value					10.00%
Aggregate purchase price for exercise of option pro-rated for any partial exercise					$ 10,000,000
In-process research and development					$ 16,514,000
Immune Ventures [Member]
Research and Development Activity (Details) [Line Items]
Milestone payment			$ 25,000
Agreement expiry period, description					The PITT Agreement expires upon the earlier of: (i) expiration of the last claim of the Patent Rights (as defined in the PITT Agreement) forming the subject matter of the PITT Agreement; or (ii) the date that is 20 years from the effective date of the agreement (June 26, 2037).
Immune Ventures [Member]
Research and Development Activity (Details) [Line Items]
Percentage of licensor royalty patent grant					1.00%
University of Pittsburg License Agreement [Member]
Research and Development Activity (Details) [Line Items]
Percentage of net sales to pay royalties					2.50%
United Kingdom [Member] | Research and Development Expense [Member]
Research and Development Activity (Details) [Line Items]
Research and development tax credit receivable					$ 2,942,000		$ 833,000
Reimbursements of research and development tax credit					0
Australia [Member]
Research and Development Activity (Details) [Line Items]
Reimbursements of research and development tax credit						$ 200,000
Australia [Member] | Subsidiaries [Member]
Research and Development Activity (Details) [Line Items]
Tax reimbursement		$ 1,300,000
Australia [Member] | Research and Development Expense [Member]
Research and Development Activity (Details) [Line Items]
Research and development tax credit receivable					2,016,000		$ 853,000
Reimbursements of research and development tax credit					$ 0

Research and Development Acti_4

Research and Development Activity (Details) - Schedule of milestone payments in consideration for the patent rights - Inkmune License Agreement [Member] - Patents [Member] - Immune Ventures LLc [Member] $ in Thousands	9 Months Ended
	Sep. 30, 2021USD ($)
Each Phase I initiation [Member]
Research and Development Activity (Details) - Schedule of milestone payments in consideration for the patent rights [Line Items]
Payment method of milestone payments	$ 25
Each Phase II initiation [Member]
Research and Development Activity (Details) - Schedule of milestone payments in consideration for the patent rights [Line Items]
Payment method of milestone payments	250
Each Phase III initiation [Member]
Research and Development Activity (Details) - Schedule of milestone payments in consideration for the patent rights [Line Items]
Payment method of milestone payments	350
Each NDA/EMA filing [Member]
Research and Development Activity (Details) - Schedule of milestone payments in consideration for the patent rights [Line Items]
Payment method of milestone payments	1,000
Each NDA/EMA awarded [Member]
Research and Development Activity (Details) - Schedule of milestone payments in consideration for the patent rights [Line Items]
Payment method of milestone payments	$ 9,000

Research and Development Acti_5

Research and Development Activity (Details) - Schedule of consideration of annual maintenance fees under the PITT agreement - University of Pittsburg License Agreement [Member] - Annual Maintenance Fees [Member] $ in Thousands	Sep. 30, 2021USD ($)
June 26 of each year 2021-2022 [Member]
Research and Development Activity (Details) - Schedule of consideration of annual maintenance fees under the PITT agreement [Line Items]
Annual maintenance fees until first commercial sale	$ 5
June 26 of each year 2023-2024 [Member]
Research and Development Activity (Details) - Schedule of consideration of annual maintenance fees under the PITT agreement [Line Items]
Annual maintenance fees until first commercial sale	10
June 26 of each year 2025 until first commercial sale [Member]
Research and Development Activity (Details) - Schedule of consideration of annual maintenance fees under the PITT agreement [Line Items]
Annual maintenance fees until first commercial sale	$ 25

Research and Development Acti_6

Research and Development Activity (Details) - Schedule of licensee is required to make milestone payments - Immune Ventures to Inmune Bio [Member] $ in Thousands	9 Months Ended
	Sep. 30, 2021USD ($)
Each Phase I initiation [Member]
Research and Development Activity (Details) - Schedule of licensee is required to make milestone payments [Line Items]
Payment method of milestone payments	$ 50
Each Phase III initiation [Member]
Research and Development Activity (Details) - Schedule of licensee is required to make milestone payments [Line Items]
Payment method of milestone payments	500
First commercial sale of product making use of licensed technology [Member]
Research and Development Activity (Details) - Schedule of licensee is required to make milestone payments [Line Items]
Payment method of milestone payments	$ 1,250

Lease (Details)

Lease (Details)	1 Months Ended
	May 31, 2019	Sep. 30, 2021
Disclosure Text Block [Abstract]
Lease term	61 months	64 months
Description of extend lease term	The lessor may extend its lease for an additional 5 years, and, if it does, the Company may also extend its sublease for 5 years.

Lease (Details) - Schedule of r

Lease (Details) - Schedule of right-of-use assets and liabilities for operating lease - USD ($) $ in Thousands	Sep. 30, 2021	Dec. 31, 2020
Schedule of right-of-use assets and liabilities for operating lease [Abstract]
Right-of-use asset – related party	$ 128	$ 156
Operating lease, current liability – related party	38	34
Long-term operating lease liability – related party	95	$ 126
Total lease liability	$ 133
Weighted-average remaining lease term	2 years 9 months 18 days
Weighted-average discount rate	10.00%

Related Party Transactions (Det

Related Party Transactions (Details) - USD ($)	9 Months Ended
	Sep. 30, 2021	Sep. 30, 2020	Dec. 31, 2020
UCL Consultants Limited [Member]
Related Party Transactions (Details) [Line Items]
Amount of company owed to UCL Consultants Limited	$ 10,000		$ 34,000
Prepaid expenses	14,000		$ 0
Payment for medical research performed expense	176,000	$ 335,000
Clinical Trial and Consulting Services [Member]
Related Party Transactions (Details) [Line Items]
Payment for medical research performed expense	0	$ 127,000
Capital contribution	$ 216,000

Debt (Details)

Debt (Details) - USD ($)	3 Months Ended	9 Months Ended
	Sep. 30, 2021	Sep. 30, 2021	Jun. 10, 2021
Debt (Details) [Line Items]
Term loan from lenders (in Dollars)			$ 15,000,000
Term loan additional from lenders (in Dollars)			$ 5,000,000
Payment to Lenders (in Dollars)		$ 47,000
Interest expense recognized (in Dollars)	$ 400,000	$ 500,000
Description of loan repayment in terms		The term loan repayment schedule provided for interest only payments beginning on July 1, 2021, and continuing for 12 months, followed by monthly principal and interest payments, starting on July 1, 2022 and continuing through the maturity date of January 1, 2025.
Interest rate	7.75%	7.75%
Original principal amount borrowed for prepayment percentage		3.00%
Original principal amount borrowed for prepayment percentage before second loan		2.00%
Original principal amount borrowed for prepayment percentage before maturity date		1.00%
Term loan repayment (in Dollars)	$ 15,000,000	$ 15,000,000
The Wall Street Journal plus [Member]
Debt (Details) [Line Items]
Prime rate, percentage		4.50%
Interest rate	7.75%	7.75%
Amount borrowed, percentage	6.50%	6.50%

Debt (Details) - Schedule of te

Debt (Details) - Schedule of term loan and debt discount $ in Thousands	Sep. 30, 2021USD ($)
Schedule of term loan and debt discount [Abstract]
Term Loan	$ 15,000
Less: debt discount and financing costs, net	(599)
Less: current portion
Long-term debt	$ 14,401

Debt (Details) - Schedule of re

Debt (Details) - Schedule of repayment term loan principal $ in Thousands	Sep. 30, 2021USD ($)
Schedule of repayment term loan principal [Abstract]
2021
2022
2023	5,833
2024	9,167
Total debt	$ 15,000

Stockholders' Equity (Details)

Stockholders' Equity (Details) - USD ($)	May 15, 2019	Sep. 30, 2021	Aug. 31, 2021	Jul. 31, 2021	Jun. 30, 2021	Mar. 31, 2021	Jan. 31, 2021	Dec. 30, 2020	Jul. 31, 2020	Jan. 31, 2020	Jun. 30, 2017	Sep. 30, 2021	Sep. 30, 2020	Sep. 30, 2021	Sep. 30, 2020	Jun. 10, 2021	Feb. 28, 2019
Stockholders' Equity (Details) [Line Items]
Number of common stock sold (in Shares)				1,818,182		713,192			2,500,000						178,600
Amount of sale						$ 45,000,000
Public offering price, per share (in Dollars per share)									$ 10
Shares issued (in Shares)																192,533
Purchase price, per share (in Dollars per share)						$ 21.73
Aggregate net proceeds				$ 36,900,000											$ 800,000
Price per share (in Dollars per share)													$ 5.45		$ 5.45
Warrants exercised (in Shares)									25,000
Expected life									5 years
Exercise price, per share (in Dollars per share)									$ 10
General and administrative expense									$ 356,874			$ 2,515,000	$ 2,457,000	$ 6,666,000	$ 4,960,000
Expected dividend, percentage									0.00%
Expected volatility rate									111.67%
Risk free rate									0.30%
Common stock issued (in Shares)									20,000					3,758
Cancelled the warrants (in Shares)									50,000
Purchase of shares (in Shares)		373,000	373,000	373,000	236,451							373,000		373,000
Aggregated fair value of stock options		$ 6,300,000	$ 6,300,000	$ 6,300,000	$ 3,300,000							$ 6,300,000		$ 6,300,000
Discount rate					1.23%		0.78%
Minimum volatility rate							113.00%
Maximum volatility rate							114.00%
Expected dividends		0	$ 0	$ 0	$ 0		$ 0
Stock-based compensation expense														3,300,000	$ 2,100,000
Unrecognized compensation cost		14,600,000										14,600,000		$ 14,600,000
Weighted-average period														2 years 8 months 23 days
Intrinsic value of warrants		$ 244,000										$ 244,000		$ 244,000
Warrant, description														In connection with the Company’s initial public offering in February 2019, the Company issued warrants to the placement agents to purchase the Company’s common stock at an exercise price of $9.60 per common share, which warrants are exercisable until December 19, 2023.
Warrants exercised (in Shares)		6,147										6,147		6,147
Shareholder rights agreement, description								the Company one one-thousandth of a share of a newly designated series of preferred stock, Series A Junior Participating Preferred Stock, par value $0.001 per share, of the Company, at an exercise price of $300.00 per one one-thousandth of a Series A Junior Participating Preferred Share, subject to adjustment. Subject to various exceptions, the Rights become exercisable in the event any person (excluding certain exempted or grandfathered persons) becomes the beneficial owner of twenty percent or more of the Company’s common stock without the approval of the Board.
Lincoln Park [Member]
Stockholders' Equity (Details) [Line Items]
Description of sale of stock	Under the terms and subject to the conditions of the securities purchase agreement, the Company had the right to sell to Lincoln Park, and Lincoln Park was obligated to purchase, up to $20.0 million in shares of the Company’s common stock, subject to certain limitations, over the 24-month period that commenced on May 15, 2019.
Employees and directors [Member]
Stockholders' Equity (Details) [Line Items]
Purchase of shares (in Shares)							198,549
Aggregated fair value of stock options							$ 4,200,000
Underwriters' Option [Member]
Stockholders' Equity (Details) [Line Items]
Number of common stock sold (in Shares)									2,500,000
Shares issued (in Shares)									326,086
Purchase price, per share (in Dollars per share)									$ 10
Aggregate net proceeds									$ 23,100,000
Underwriting discounts									$ 1,900,000
2020 ATM Program [Member]
Stockholders' Equity (Details) [Line Items]
Number of common stock sold (in Shares)														1,439,480
Price per share (in Dollars per share)		$ 20.17										$ 20.17		$ 20.17
BTIG's Commission [Member]
Stockholders' Equity (Details) [Line Items]
Aggregate net proceeds														$ 14,900,000
2021 ATM Program [Member]
Stockholders' Equity (Details) [Line Items]
Number of common stock sold (in Shares)														713,192
Price per share (in Dollars per share)		$ 21.73										$ 21.73		$ 21.73
Warrant [Member]
Stockholders' Equity (Details) [Line Items]
Warrants exercised (in Shares)									25,000
Exercise price, per share (in Dollars per share)									$ 5.5
Minimum [Member]
Stockholders' Equity (Details) [Line Items]
Expected life		6 years	6 years	6 years	6 years		6 years
Discount rate		0.96%	0.96%	0.96%
Minimum volatility rate		105.00%	105.00%	105.00%	107.00%
Maximum [Member]
Stockholders' Equity (Details) [Line Items]
Expected life		10 years	10 years	10 years	6 years 3 months		6 years 3 months
Discount rate		1.31%	1.31%	1.31%
Maximum volatility rate		109.00%	109.00%	109.00%	108.00%
2019 Incentive Stock Plan [Member]
Stockholders' Equity (Details) [Line Items]
Common stock issued (in Shares)									20,000
Market value of the common stock									$ 230,000
Common Stock [Member]
Stockholders' Equity (Details) [Line Items]
Number of common stock sold (in Shares)										220,000
Amount of sale										$ 1,000,000
Common Stock [Member] | Lincoln Park [Member]
Stockholders' Equity (Details) [Line Items]
Sale of value	$ 20,000,000
Issuance of shares (in Shares)															196,000
Issuance of value															$ 1,000,000
Common Stock [Member] | BTIG's Commission [Member]
Stockholders' Equity (Details) [Line Items]
Aggregate net proceeds														$ 28,400,000
Common Stock [Member] | Warrant [Member]
Stockholders' Equity (Details) [Line Items]
Warrants exercised (in Shares)									50,000
Expected life									5 years
Warrant [Member]
Stockholders' Equity (Details) [Line Items]
Number of common stock sold (in Shares)											31,667
Warrants exercised (in Shares)		11,875										11,875		11,875
Expected life					10 years
Expected volatility rate					103.00%
Aggregated fair value of stock options					$ 600,000
Discount rate					1.45%
Expected dividends					$ 0
Warrants issued (in Shares)					45,386
Exercise price (in Dollars per share)					$ 14.05						$ 1.5						$ 9.6
Warrants are outstanding (in Shares)		28,688										28,688		28,688
Warrants intrinsic value		$ 282,000										$ 282,000		$ 282,000
Expiration date											Jun. 30, 2022
Cash proceeds														$ 18,000
Warrants are outstanding (in Shares)		19,792										19,792		19,792
Warrant [Member] | Common Stock [Member]
Stockholders' Equity (Details) [Line Items]
Warrants intrinsic value		$ 355,000										$ 355,000		$ 355,000

Stockholders' Equity (Details)

Stockholders' Equity (Details) - Schedule of stock option activity $ / shares in Units, $ in Thousands	9 Months Ended
	Sep. 30, 2021USD ($)$ / sharesshares
Schedule of stock option activity [Abstract]
Number of shares, Outstanding, Beginning balance (in Shares) | shares	3,457,000
Weighted- average Exercise Price, Outstanding, Beginning balance	$ 5.82
Weighted-average Remaining Contractual Term (years), Outstanding, Beginning balance	8 years 18 days
Aggregate Intrinsic Value, Outstanding, Beginning balance (in Dollars) | $	$ 39,405
Number of shares, Options granted (in Shares) | shares	808,000
Weighted- average Exercise Price, Options granted	$ 20.73
Weighted- average Remaining Contractual Term (years), Options granted	10 years
Aggregate Intrinsic Value, Options granted
Number of shares, Options exercised (in Shares) | shares	(183,000)
Weighted- average Exercise Price, Options exercised	$ 6.21
Weighted- average Remaining Contractual Term (years), Options exercised
Aggregate Intrinsic Value, Options exercised (in Dollars) | $
Number of shares, Options cancelled (in Shares) | shares
Weighted- average Exercise Price, Options cancelled
Weighted- average Remaining Contractual Term (years), Options cancelled
Aggregate Intrinsic Value, Options cancelled (in Dollars) | $
Number of shares, Outstanding, Ending balance (in Shares) | shares	4,082,000
Weighted- average Exercise Price, Outstanding, Ending balance	$ 8.65
Weighted-average Remaining Contractual Term (years), Outstanding, Ending balance	7 years 5 months 8 days
Aggregate Intrinsic Value, Outstanding, Ending balance (in Dollars) | $	$ 45,171
Number of shares, Exercisable, Ending balance (in Shares) | shares	2,578,000
Weighted- average Exercise Price, Exercisable, Ending balance	$ 6.49
Weighted-average Remaining Contractual Term (years), Exercisable, Ending balance	7 years 1 month 2 days
Aggregate Intrinsic Value, Exercisable, Ending balance (in Dollars) | $	$ 33,395

Stockholders' Equity (Details_2

Stockholders' Equity (Details) - Schedule of stock-based compensation expense - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2021	Sep. 30, 2020	Sep. 30, 2021	Sep. 30, 2020
Research and development [Member]
Stockholders' Equity (Details) - Schedule of stock-based compensation expense [Line Items]
Total	$ 705	$ 146	$ 1,090	$ 423
General and administrative [Member]
Stockholders' Equity (Details) - Schedule of stock-based compensation expense [Line Items]
Total	901	900	2,184	1,986
Total [Member]
Stockholders' Equity (Details) - Schedule of stock-based compensation expense [Line Items]
Total	$ 1,606	$ 1,046	$ 3,274	$ 2,409

Collaborative Agreements (Detai

Collaborative Agreements (Details) - USD ($) $ in Thousands	1 Months Ended
	Dec. 31, 2020	Sep. 30, 2020	Sep. 30, 2021
Collaborative Agreements (Details) [Line Items]
Grand award,description	During 2020, the Company was awarded a $0.5 million grant from the Amyotrophic Lateral Sclerosis (“ALS”) Association to fund a study of the efficacy of XPro1595 to reverse ALS in vitro and to fund a study of the efficacy of XPro1595 to protect against ALS model phenotypes in vivo.	the Company was awarded a grant of up to $2.9 million from the National Institutes of Health (“NIH”). The grant will support a Phase 2 study of XPro1595 in patients with treatment resistant depression. As of September 30, 2021, the Company has not received any proceeds pursuant to this grant.
Grants received		$ 300	$ 100
Deferred liabilities	$ 190		541
ALS [Member]
Collaborative Agreements (Details) [Line Items]
Deferred liabilities	$ 100		$ 200

Commitments and Contingencies_2

Commitments and Contingencies (Details) - USD ($)	3 Months Ended	9 Months Ended
	Sep. 30, 2021	Sep. 30, 2021	May 31, 2019
Commitments and Contingencies Disclosure [Abstract]
Lease term	64 months	64 months	61 months
Operating lease expense	$ 19,000	$ 45,000

Commitments and Contingencies_3

Commitments and Contingencies (Details) - Schedule of future minimum payments pursuant to the lease $ in Thousands	Sep. 30, 2021USD ($)
Schedule of future minimum payments pursuant to the lease [Abstract]
2021	$ 23
2022	157
2023	237
2024	220
2025	193
Thereafter	216
Total	$ 1,046