Exhibit 31.3
CERTIFICATION OF PERIODIC REPORT UNDER SECTION 302 OF
THE SARBANES-OXLEY ACT OF 2002
I, Ryan J. Watts, certify that:
| 1. | I have reviewed this Amendment No. 1 to the Annual Report onForm 10-K of Denali Therapeutics Inc.; and |
| 2. | Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report. |
Date: July 13, 2018
| /s/ Ryan J. Watts |
| Ryan J. Watts, Ph.D. |
| President and Chief Executive Officer |
