| Document and Entity Information | May 23, 2022 |
| Cover [Abstract] | |
| Document Type | 8-K |
| Amendment Flag | false |
| Document Period End Date | May 23, 2022 |
| Entity Registrant Name | ENTASIS THERAPEUTICS HOLDINGS INC. |
| Entity Incorporation, State or Country Code | DE |
| Entity File Number | 001-38670 |
| Entity Tax Identification Number | 82-4592913 |
| Entity Address, Address Line One | 35 Gatehouse Drive |
| Entity Address, City or Town | Waltham |
| Entity Address, State or Province | MA |
| Entity Address, Postal Zip Code | 02451 |
| City Area Code | 781 |
| Local Phone Number | 810-0120 |
| Written Communications | false |
| Soliciting Material | false |
| Pre-commencement Tender Offer | false |
| Pre-commencement Issuer Tender Offer | false |
| Entity Emerging Growth Company | true |
| Entity Ex Transition Period | true |
| Entity Central Index Key | 0001724344 |
| Title of 12(b) Security | Common Stock, par value $0.001 per share |
| Trading Symbol | ETTX |
| Security Exchange Name | NASDAQ |
