| Cover | Feb. 24, 2022 |
| Cover [Abstract] | |
| Document Type | 8-K |
| Document Period End Date | Feb. 24, 2022 |
| Entity Registrant Name | ZENTALIS PHARMACEUTICALS, INC. |
| Entity Incorporation, State or Country Code | DE |
| Entity File Number | 001-39263 |
| Entity Tax Identification Number | 82-3607803 |
| Entity Address, Address Line One | 1359 Broadway |
| Entity Address, Address Line Two | Suite 1710 |
| Entity Address, City or Town | New York |
| Entity Address, State or Province | NY |
| Entity Address, Postal Zip Code | 10018 |
| City Area Code | 212) |
| Local Phone Number | 433-3791 |
| Written Communications | false |
| Soliciting Material | false |
| Pre-commencement Tender Offer | false |
| Pre-commencement Issuer Tender Offer | false |
| Title of 12(b) Security | Common Stock, $0.001 par value per share |
| Trading Symbol | ZNTL |
| Security Exchange Name | NASDAQ |
| Entity Emerging Growth Company | false |
| Entity Central Index Key | 0001725160 |
| Amendment Flag | false |
