RiverVest Venture Fund IV SC 13D Xilio Therapeutics / RiverVest Venture Fund IV ownership change

RiverVest Venture Fund IV SC 13DXilio Therapeutics / RiverVest Venture Fund IV ownership change

SECURITIES AND EXCHANGE COMMISSION

WASHINGTON, DC 20549

SCHEDULE 13D

Under the Securities Exchange Act of 1934

XILIO THERAPEUTICS, INC.

(Name of Issuer)

Common Stock, par value $0.0001 per share

(Title of Class of Securities)

98422T100

(CUSIP Number)

Nancy A. Hong, Ph.D

101 S. Hanley Road, Suite 1850

St. Louis, MO 63105

(314) 726-6700

With copy to:

Gloria M. Skigen, Esq.

Holland & Knight LLP

One Stamford Plaza, 263 Tresser Boulevard, Suite 1400

Stamford, CT 06901

(203) 905-4526

(Name, Address and Telephone Number of Person Authorized to Receive Notices and Communications)

October 26, 2021

(Date of Event which Requires Filing of this Statement)

If the filing person has previously filed a statement on Schedule 13G to report the acquisition that is the subject of this Schedule 13D, and is filing this schedule because of §§240.13d-1(e), 240.13d-1(f) or 240.13d-1(g), check the following box: ☐

*	The remainder of this cover page shall be filled out for a reporting person’s initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter disclosures provided in a prior cover page.

The information required on the remainder of this cover page shall not be deemed to be “filed” for the purpose of Section 18 of the Securities Exchange Act of 1934 (“Act”) or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).


CUSIP No. 98422T100		13D		Page 2 of 13 Pages


1		NAME OF REPORTING PERSON I.R.S. IDENTIFICATION NO. (ENTITIES ONLY) RiverVest Venture Fund IV, L.P.
2		CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (a) ☐ (b) ☐
3		SEC USE ONLY
4		SOURCE OF FUNDS WC
5		CHECK IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e) ☐
6		CITIZENSHIP OR PLACE OF ORGANIZATION Delaware, USA

(1)

The percentage set forth in row (13) is based on the 26,666,008 outstanding shares of common stock, par value $0.0001 per share (“Common Stock”), of Xilio Therapeutics, Inc., a Delaware corporation (the “Issuer”), reported by the Issuer to be outstanding immediately after the Issuer’s initial public offering on the Issuer’s prospectus filed under Rule 424(b)(4), filed with the Securities and Exchange Commission (“SEC”) on October 22, 2021.


CUSIP No. 98422T100		13D		Page 3 of 13 Pages


1		NAME OF REPORTING PERSON I.R.S. IDENTIFICATION NO. (ENTITIES ONLY) RiverVest Venture Partners IV, L.P.
2		CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (a) ☐ (b) ☐
3		SEC USE ONLY
4		SOURCE OF FUNDS AF
5		CHECK IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e) ☐
6		CITIZENSHIP OR PLACE OF ORGANIZATION Delaware, USA

(2)	Represents 1,441,444 shares of Common Stock owned by RiverVest Venture Fund IV, L.P., a Delaware limited partnership (“RiverVest IV”). RiverVest Venture Partners IV, L.P., a Delaware limited partnership (“RiverVest Partners IV”), is the general partner of RiverVest IV.


CUSIP No. 98422T100		13D		Page 4 of 13 Pages


1		NAME OF REPORTING PERSON I.R.S. IDENTIFICATION NO. (ENTITIES ONLY) RiverVest Venture Partners IV, LLC
2		CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (a) ☐ (b) ☐
3		SEC USE ONLY
4		SOURCE OF FUNDS AF
5		CHECK IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e) ☐
6		CITIZENSHIP OR PLACE OF ORGANIZATION Delaware, USA

(3)	Represents 1,441,444 shares of Common Stock owned by RiverVest IV. RiverVest Venture Partners IV, LLC, a Delaware limited liability company, is the general partner of RiverVest Partners IV, which is the general partner of RiverVest IV.


CUSIP No. 98422T100		13D		Page 5 of 13 Pages


1		NAME OF REPORTING PERSON I.R.S. IDENTIFICATION NO. (ENTITIES ONLY) Niall O’Donnell, Ph.D.
2		CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (a) ☐ (b) ☐
3		SEC USE ONLY
4		SOURCE OF FUNDS AF
5		CHECK IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e) ☐
6		CITIZENSHIP OR PLACE OF ORGANIZATION USA

(4)	Represents 1,441,444 shares of Common Stock owned by RiverVest IV. Dr. O’Donnell is a member of RiverVest Venture Partners IV, LLC, which is the general partner of RiverVest Partners IV, which is the general partner of RiverVest IV.


CUSIP No. 98422T100		13D		Page 6 of 13 Pages


1		NAME OF REPORTING PERSON I.R.S. IDENTIFICATION NO. (ENTITIES ONLY) John P. McKearn, Ph.D
2		CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (a) ☐ (b) ☐
3		SEC USE ONLY
4		SOURCE OF FUNDS AF
5		CHECK IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e) ☐
6		CITIZENSHIP OR PLACE OF ORGANIZATION USA

(5)	Represents 1,441,444 shares of Common Stock owned by RiverVest IV. Dr. McKearn is a member of RiverVest Venture Partners IV, LLC, which is the general partner of RiverVest Partners IV, which is the general partner of RiverVest IV.


CUSIP No. 98422T100		13D		Page 7 of 13 Pages


1		NAME OF REPORTING PERSON I.R.S. IDENTIFICATION NO. (ENTITIES ONLY) Jay Schmelter
2		CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (a) ☐ (b) ☐
3		SEC USE ONLY
4		SOURCE OF FUNDS AF
5		CHECK IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e) ☐
6		CITIZENSHIP OR PLACE OF ORGANIZATION USA

(6)	Represents 1,441,444 shares of Common Stock owned by RiverVest IV. Mr. Schmelter is a member of RiverVest Venture Partners IV, LLC, which is the general partner of RiverVest Partners IV, which is the general partner of RiverVest IV.


CUSIP No. 98422T100		13D		Page 8 of 13 Pages

Item 1. Security and Issuer.

The title and class of securities to which this Statement on Schedule 13D (this “Statement”) relates is the common stock, par value $0.0001 per share (the “Common Stock”), of Xilio Therapeutics, Inc., a Delaware corporation (the “Issuer”). The address of the principal executive offices of the Issuer is 828 Winter Street, Suite 300, Waltham, Massachusetts 02451. Information given in response to each item shall be deemed incorporated by reference in all other items as applicable.

Item 2. Identity and Background.

(a)

Name of Person Filing (each a “Reporting Person” and collectively, the “Reporting Persons”)

RiverVest Venture Fund IV, L.P., a Delaware limited partnership

RiverVest Venture Partners IV, L.P., a Delaware limited partnership

RiverVest Venture Partners IV, LLC, a Delaware limited liability company

Niall O’Donnell, Ph.D

John P. McKearn, Ph.D

Jay Schmelter

RiverVest IV is referred to herein as the “Control Entity.” Each of RiverVest Partners IV and RiverVest Venture Partners IV, LLC are referred to herein as the “Managing Entities.” Messrs. O’Donnell, McKearn and Schmelter are referred to herein as the “Managers.”

(b)

Residence or Business Address

101 S. Hanley Road, Suite 1850, St. Louis, MO 63105.

(c)

Present Principal Occupation or Employment

The principal business of the Control Entity is making venture capital investments. The principal business of each of the Managing Entities is acting as the general partner or member (directly or indirectly) of the Control Entity. The principal business of the Manager is managing the Managing Entities and a number of affiliated partnerships and other entities with similar businesses.

(d)

During the last five years, none of the Reporting Persons has been convicted in a criminal proceeding (excluding traffic violations or similar misdemeanors).

(e)

During the last five years, none of the Reporting Persons has been named as a party to a civil proceeding of a judicial or administrative body of competent jurisdiction and as a result of such proceeding was or is subject to a judgment, decree or final order enjoining future violations of, or prohibiting or mandating activities subject to, federal or state securities laws or finding any violation with respect to such laws.

(f)

Each of the Reporting Persons who is a natural person is a citizen of the United States of America.

Item 3. Source and Amount of Funds or Other Consideration.

Prior to the Issuer’s initial public offering (the “IPO”) the Reporting Persons held the following securities of the Issuer:

RiverVest IV purchased an aggregate of 3,942,569 Series B preferred units (which converted into shares of Series B preferred stock of the issuer on a 1-to-1 basis upon the reorganization of the Issuer from a limited liability company to a corporation), 3,952,569 shares of Series B preferred stock of the Issuer (together with the Series B preferred units of the Issuer, the “Series B Preferred Stock”) and an aggregate of 3,413,582 shares of Series C preferred stock of the Issuer (“Series C Preferred Stock”) in a series of private placement transactions for an aggregate purchase price of $14,749,999.92.


CUSIP No. 98422T100		13D		Page 9 of 13 Pages

On October 15, 2021, the Issuer effected a 9.5-for-1 reverse stock split for each share of issued and outstanding Common Stock. On October 26, 2021, the Issuer completed the closing IPO. All shares of Series B Preferred Stock and Series C Preferred Stock issued and outstanding converted on a 1-for-9.5 basis into shares of Common Stock in connection with the IPO. In addition, concurrently with the closing of the IPO, RiverVest IV purchased an aggregate of 250,000 shares of Common Stock in the IPO at the IPO price of $16.00 per share.

The purchase price paid by the Control Entities for all of the shares described in this Item 3 came from the capital contributions of their general and limited partners.

Item 4. Purpose of the Transaction.

The Reporting Persons purchased the shares of Series B Preferred Stock and Series C Preferred Stock described above for investment purposes. Except as set forth in Item 6 below, none of the Reporting Persons has any present plans which relate to or would result in:

(a)

The acquisition by any person of additional securities of the Issuer, or the disposition of securities of the Issuer;

(b)

An extraordinary corporate transaction, such as a merger, reorganization or liquidation, involving the Issuer or any of its subsidiaries;

(c)

A sale or transfer of a material amount of assets of the Issuer or any of its subsidiaries;

(d)

Any change in the present board of directors or management of the Issuer, including any plans or proposals to change the number or term of directors or to fill any existing vacancies on the board;

(e)

Any material change in the present capitalization or dividend policy of the Issuer;

(f)

Any other material change in the Issuer’s business or corporate structure;

(g)

Changes in the Issuer’s charter, bylaws or instruments corresponding thereto or other actions which may impede the acquisition of control of the Issuer by any person;

(h)

Causing a class of securities of the Issuer to be delisted from a national securities exchange or to cease to be authorized to be quoted in an inter-dealer quotation system of a registered national securities association;

(i)

A class of equity securities of the Issuer becoming eligible for termination of registration pursuant to Section 12(g)(4) of the Securities Exchange Act of 1934, as amended (the “Act”); or

(j)

Any action similar to any of those enumerated above.


CUSIP No. 98422T100		13D		Page 10 of 13 Pages

However, each of the Reporting Persons reserve the right to propose or participate in future transactions which may result in one or more of such actions, including but not limited to, an extraordinary corporate transaction, such as a merger, reorganization or liquidation, sale of a material amount of assets of the Issuer or its subsidiaries, or other transactions which might have the effect of causing the Common Stock to become eligible for termination of registration under Section 12(g) of the Act. The Reporting Persons also retain the right to change their investment intent at any time, to acquire additional shares of Common Stock or other securities of the Issuer from time to time, or to sell or otherwise dispose of all or part of the Common Stock beneficially owned by them (or any shares of Common Stock into which such securities are converted) in any manner permitted by law. The Reporting Persons may engage from time to time in ordinary course transactions with financial institutions with respect to the securities described herein.

Item 5. Interest in Securities of the Issuer.

(a) and (b)


Entity or Individual	Shares Held Directly		Sole Voting Power		Shared Voting Power		Sole Dispositive Power		Shared Dispositive Power		Beneficial Ownership		Percentage of Class^(*)
RiverVest Venture Fund IV, L.P.		1,441,444		0		1,441,444		0		1,441,444		1,441,444		5.4	%
RiverVest Venture Partners IV, L.P.⁽¹⁾		0		0		1,441,444		0		1,441,444		1,441,444		5.4	%
RiverVest Venture Partners IV, LLC⁽²⁾		0		0		1,441,444		0		1,441,444		1,441,444		5.4	%
Niall O’Donnell, Ph.D⁽³⁾		0		0		1,441,444		0		1,441,444		1,441,444		5.4	%
John P. McKearn, Ph.D⁽⁴⁾		0		0		1,441,444		0		1,441,444		1,441,444		5.4	%
Jay Schmelter⁽⁵⁾		0		0		1,441,444		0		1,441,444		1,441,444		5.4	%

(*)	Based on the 26,666,008 outstanding shares of Common Stock of the Issuer, reported by the Issuer to be outstanding immediately after the IPO on the Issuer’s prospectus filed under Rule 424(b)(4), filed with the SEC on October 22, 2021.

(1)	RiverVest Partners IV is the general partner of RiverVest IV, and as a result, may be deemed to beneficially own the 1,441,444 shares of Common Stock owned by RiverVest IV.

(2)	RiverVest Venture Partners IV, LLC is the sole general partner of RiverVest Partners IV, which is the general partner of RiverVest IV, and as a result, may be deemed to beneficially own the 1,441,444 shares of Common Stock owned by RiverVest IV.

(3)

Dr. O’Donnell is a member of RiverVest Venture Partners IV, LLC, which is the sole general partner of RiverVest Partners IV. RiverVest Partners IV is the general partner of RiverVest IV. As a result, Dr. O’Donnell may be deemed to beneficially own the 1,441,444 shares of Common Stock owned by RiverVest IV.

(4)

Dr. McKearn is a member of RiverVest Venture Partners IV, LLC, which is the sole general partner of RiverVest Partners IV. RiverVest Partners IV is the general partner of RiverVest IV. As a result, Dr. McKearn may be deemed to beneficially own the 1,441,444 shares of Common Stock owned by RiverVest IV.

(5)

Mr. Schmelter is a member of RiverVest Venture Partners IV, LLC, which is the sole general partner of RiverVest Partners IV. RiverVest Partners IV is the general partner of RiverVest IV. As a result, Mr. Schmelter may be deemed to beneficially own the 1,441,444 shares of Common Stock owned by RiverVest IV.

By virtue of the relationships described herein, the Reporting Persons may be deemed to constitute a “group” for purposes of Section 13(d)(3) of the Act. The filing of this Statement shall not be construed as an admission that the Reporting Persons are a group, or have agreed to act as a group. Each Reporting Person expressly disclaims beneficial ownership of the securities reported herein, except to the extent such Reporting Person actually exercises voting or dispositive power with respect to such securities.


CUSIP No. 98422T100		13D		Page 11 of 13 Pages

(c)	Except as set forth herein, none of the Reporting Persons has effected any transactions in shares of the Issuer’s Common Stock during the last 60 days.

(d)	No other person is known to have the right to receive or the power to direct the receipt of dividends from, or any proceeds from the sale of, the shares of Common Stock beneficially owned by any of the Reporting Persons.

(e)	Not applicable.

Item 6. Contracts, Arrangements, Understandings or Relationships With Respect to Securities of the Issuer.

Registration Rights

The Issuer, RiverVest IV, and certain other investors are party to that certain amended and restated registration rights agreement (the “Registration Rights Agreement”), dated February 23, 2021, giving such parties the right to demand the registration of their shares of Common Stock (the “registerable securities”) under the Securities Act of 1933, as amended. Beginning 180 days after the completion of the IPO, the holders of a majority of the then-outstanding registrable securities have demand rights to request the registration on Form S-1 of their registrable securities, provided the anticipated aggregate offering price is at least $10.0 million. The Issuer is required to file up to two registration statements that are declared effective upon exercise of these demand registration rights. In addition, the holders of at least twenty-five percent (25%) then-outstanding registrable securities can request that the Issuer register all or part of their shares on Form S-3 if the Issuer is eligible to file a registration statement on Form S-3 and if the aggregate price to the public of the shares offered is at least $3.0 million. The stockholders may only require two registration statements on Form S-3 in a 12-month period. If the Issuer registers any of its securities for public sale, holders of then-outstanding registrable securities or their permitted transferees will have the right to include their registrable securities in such registration statement, subject to certain exclusions. All of these registration rights will expire, with respect to any particular holder, upon the earliest to occur of: (a) the closing of a merger or consolidation in which the Issuer constitutes a constituent party or a subsidiary of the Issuer is a constituent party and the Issuer issues shares of its capital stock pursuant to such merger or consolidation (subject to certain exceptions), or the sale, lease, transfer, exclusive license or other disposition by the Company of all or substantially all of its assets; (b) a stockholder holds less than 1% of the Issuer’s outstanding Common Stock or can sell all of its registrable securities under Rule 144A of the Securities Act during any 3-month period or (c) on the fifth anniversary of the consummation of the IPO.

This foregoing description of the Registration Rights Agreement is qualified in its entirety by reference to the Registration Rights Agreement, a copy of which is filed as Exhibit B hereto and is incorporated herein by reference.

Lock-up Agreement

The Issuer, along with its directors, executive officers and substantially all of its other stockholders, including RiverVest IV, have agreed with the underwriters for the IPO that they will not, subject to limited exceptions, during the period ending 180 days following the completion of the IPO, offer, pledge, sell, contract to sell, sell any option or contract to purchase, purchase any option or contract to sell, grant any option, right or warrant to purchase or otherwise transfer or dispose of, directly or indirectly, any of shares of the Issuer’s common stock beneficially owned (as such term is used in Rule 13d-3 of the Exchange Act) or any other securities so owned convertible into or exercisable or exchangeable for shares of the Issuer’s common stock, or make any public announcement of an intention to do any of the foregoing, or enter into any swap or any other arrangement that transfers to another, in whole or in part, any of the economic consequence of ownership of the securities.


CUSIP No. 98422T100		13D		Page 12 of 13 Pages

Item 7. Material to be Filed as Exhibits.


Exhibit A:		Joint Filing Agreement, dated November 5, 2021, by and among RiverVest Venture Fund IV, L.P., RiverVest Venture Partners IV, L.P., RiverVest Venture Partners IV, LLC, Niall O’Donnell, Ph.D, John McKearn, Ph.D and Jay Schmelter.

Exhibit B:		Amended and Restated Registration Rights Agreement, dated February 23, 2021 (incorporated by reference to Exhibit 10.01 to the Issuer’s Registration Statement on Form S-1 (Registration No. 333-259973), filed with the SEC on October 1, 2021).

Exhibit C:		Form of Lock-up Agreement (incorporated by reference to Exhibit A to that certain Underwriting Agreement between the Issuer and the Underwriters (as defined therein) filed as Exhibit 1.1 to the Issuer’s Registration Statement on Form S-1/A (Registration No. 333-259973), filed with the Commission on October 18, 2021).


CUSIP No. 98422T100		13D		Page 13 of 13 Pages

SIGNATURES

After reasonable inquiry and to the best of our knowledge and belief, the undersigned certify that the information set forth in this statement is true, complete and correct.

November 5, 2021


RiverVest Venture Fund IV, L.P.		RiverVest Venture Partners IV, L.P.

By:	RiverVest Venture Partners IV, L.P.,	By:	RiverVest Venture Partners IV, LLC,
	its general partner		its sole general partner
By:	RiverVest Venture Partners IV, LLC, its sole general partner

		By:	/s/ Jay Schmelter
			Name: Jay Schmelter Title: Member
By:	/s/ Jay Schmelter
	Name: Jay Schmelter
	Title: Member

RiverVest Venture Partners IV, LLC

By:	/s/ Jay Schmelter	/s/ Niall O’Donnell, Ph.D
	Name: Jay Schmelter	Niall O’Donnell, Ph.D
	Title: Member

		/s/ John P. McKearn, Ph.D
		John P. McKearn, Ph.D

		/s/ Jay Schmelter
		Jay Schmelter

[Signature Page of Schedule 13D]

NUMBER OF
SHARES
BENEFICIALLY
OWNED BY
EACH
REPORTING
PERSON
WITH

SOLE VOTING POWER

0

SHARED VOTING POWER

1,441,444

SOLE DISPOSITIVE POWER

0

SHARED DISPOSITIVE POWER

1,441,444