Consent of Independent Registered Public Accounting Firm
We consent to the reference to our firm under the caption "Experts" in this Post-Effective Amendment No. 1 to the Registration Statement (Form S-4 No. 333-223255) and related Prospectus of Nautilus Holdco, Inc. for the registration of common stock and to the incorporation by reference therein of our reports dated March 7, 2018, with respect to the financial statements of Idera Pharmaceuticals, Inc. and the effectiveness of internal control over financial reporting of Idera Pharmaceuticals, Inc., included in its Annual Report (Form 10-K) for the year ended December 31, 2017, filed with the Securities and Exchange Commission.
| /s/ Ernst & Young LLP Philadelphia, Pennsylvania May 16, 2018 |
