Exhibit 23.1
CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM
We hereby consent to the incorporation by reference in this Registration Statement onForm S-8 of Orchard Therapeutics plc of our report dated March 22, 2019relating to the financial statements, which appears in Orchard Therapeutics plc’s Annual Report on Form20-F for the year ended December 31, 2018.
/s/ PricewaterhouseCoopers LLP
Reading, United Kingdom
March 22, 2019
