Exhibit 23.3
CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM
We hereby consent to the incorporation by reference in this Registration Statement on FormF-3 of Orchard Therapeutics plc of our report dated March 22, 2019relating to the financial statements, which appears in Orchard Therapeutics plc’s Annual Report on Form20-F for the year ended December 31, 2018. We also consent to the reference to us under the heading “Experts” in such Registration Statement.
/s/ PricewaterhouseCoopers LLP
Reading, United Kingdom
November 1, 2019