Exhibit 23.1
CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM
We consent to the incorporation by reference in this Registration Statement onForm S-8 of our report dated February 19, 2019 relating to the financial statements of Kaleido Biosciences, Inc., which appears in Amendment No. 2 to Registration StatementNo. 333-229204 of Kaleido Biosciences, Inc.
/s/ Deloitte & Touche LLP
Boston, Massachusetts
March 8, 2019