Consent of Independent Registered Public Accounting Firm
We consent to the reference to our firm under the caption "Experts" and to the use of our dual-dated report dated March 4, 2019 and April 9, 2019 in the Registration Statement (Form S-1) and related Prospectus of Cyclerion Therapeutics, Inc. dated April 18, 2019.
/s/ Ernst & Young LLP
Boston, Massachusetts
April 18, 2019
