CYCELRION THERAPEUTICS, INC.
301 Binney Street
Cambridge, MA 02142
August 12, 2020
By EDGAR
Securities and Exchange Commission
Division of Corporation Finance
100 F Street, N.E.
Washington, D.C. 20549
Attention: Margaret Schwartz
| Re: | Cyclerion Therapeutics, Inc. (the “Company”) | ||
| Registration Statement on Form S-3 | |||
| File No. 333-242334 | |||
Ladies and Gentlemen:
Pursuant to Rule 461 under the Securities Act of 1933, as amended, the Company hereby requests acceleration of the effective date of the above referenced Registration Statement to 4:00 p.m., Eastern time, on August 14, 2020, or as soon thereafter as practicable, or at such other time as the Company or its outside counsel, Hughes Hubbard & Reed LLP, request by telephone that such Registration Statement be declared effective.
Please contact Gary J. Simon, of Hughes Hubbard & Reed LLP, special counsel to the Company, at (212) 837-6770, as soon as the Registration Statement has been declared effective, or if you have any other questions or concerns regarding this matter.
| Very truly yours, | |||
| CYCLERION THERAPEUTICS, INC. | |||
| By: | /s/ William I. Huyett | ||
| Name: | William I. Huyett | ||
| Title: | Chief Financial Officer | ||
| cc: Hughes Hubbard & Reed LLP | |||
