Document and Entity Information
Document and Entity Information - shares | 6 Months Ended | |
Jun. 30, 2020 | Aug. 05, 2020 | |
Cover [Abstract] | ||
Document Type | 10-Q | |
Amendment Flag | false | |
Document Period End Date | Jun. 30, 2020 | |
Document Fiscal Year Focus | 2020 | |
Document Fiscal Period Focus | Q2 | |
Trading Symbol | ARCT | |
Entity Registrant Name | ARCTURUS THERAPEUTICS HOLDINGS INC. | |
Entity Central Index Key | 0001768224 | |
Entity Current Reporting Status | Yes | |
Entity Interactive Data Current | Yes | |
Current Fiscal Year End Date | --12-31 | |
Entity Filer Category | Accelerated Filer | |
Entity Small Business | true | |
Entity Emerging Growth Company | false | |
Entity Shell Company | false | |
Title of 12(b) Security | Common Stock, par value $0.001 per share | |
Security Exchange Name | NASDAQ | |
Entity File Number | 001-38942 | |
Entity Incorporation, State or Country Code | DE | |
Entity Tax Identification Number | 32-0595345 | |
Entity Address, Address Line One | 10628 Science Center Drive | |
Entity Address, Address Line Two | Suite 250 | |
Entity Address, City or Town | San Diego | |
Entity Address, State or Province | CA | |
Entity Address, Postal Zip Code | 92121 | |
City Area Code | 858 | |
Local Phone Number | 900-2660 | |
Entity Common Stock, Shares Outstanding | 24,388,176 | |
Document Quarterly Report | true | |
Document Transition Report | false |
CONDENSED CONSOLIDATED BALANCE
CONDENSED CONSOLIDATED BALANCE SHEETS - USD ($) $ in Thousands | Jun. 30, 2020 | Dec. 31, 2019 |
Current assets: | ||
Cash and cash equivalents | $ 136,111 | $ 71,353 |
Accounts receivable | 2,829 | 2,179 |
Prepaid expenses and other current assets | 3,060 | 758 |
Total current assets | 142,000 | 74,290 |
Property and equipment, net | 2,610 | 2,349 |
Operating lease right-of-use asset, net | 5,218 | 5,134 |
Equity-method investment | 263 | |
Non-current restricted cash | 107 | 107 |
Total assets | 149,935 | 82,143 |
Current liabilities: | ||
Accounts payable | 4,395 | 5,793 |
Accrued liabilities | 11,883 | 7,134 |
Deferred revenue | 6,768 | 8,397 |
Total current liabilities | 23,046 | 21,324 |
Deferred revenue, net of current portion | 14,013 | 15,182 |
Long-term debt | 15,059 | 14,995 |
Operating lease liability, net of current portion | 4,394 | 4,850 |
Total liabilities | 56,512 | 56,351 |
Stockholders' equity | ||
Common stock: $0.001 par value; 30,000 shares authorized; 20,610 and 15,138 issued and outstanding at June 30, 2020 and December 31, 2019, respectively. | 21 | 15 |
Additional paid-in capital | 185,110 | 97,445 |
Accumulated deficit | (91,708) | (71,668) |
Total stockholders' equity | 93,423 | 25,792 |
Total liabilities and stockholders' equity | $ 149,935 | $ 82,143 |
CONDENSED CONSOLIDATED BALANC_2
CONDENSED CONSOLIDATED BALANCE SHEETS (Parenthetical) - $ / shares | Jun. 30, 2020 | Dec. 31, 2019 |
Statement Of Financial Position [Abstract] | ||
Common stock, par value | $ 0.001 | $ 0.001 |
Common stock, shares authorized | 30,000,000 | 30,000,000 |
Common stock, shares issued | 20,610,000 | 15,138,000 |
Common stock, shares outstanding | 20,610,000 | 15,138,000 |
CONDENSED CONSOLIDATED STATEMEN
CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS - USD ($) shares in Thousands, $ in Thousands | 3 Months Ended | 6 Months Ended | ||
Jun. 30, 2020 | Jun. 30, 2019 | Jun. 30, 2020 | Jun. 30, 2019 | |
Statement Of Income And Comprehensive Income [Abstract] | ||||
Collaboration revenue | $ 2,322 | $ 10,153 | $ 4,968 | $ 14,503 |
Operating expenses: | ||||
Research and development, net | 7,944 | 7,269 | 15,861 | 14,593 |
General and administrative | 4,420 | 3,456 | 8,611 | 6,990 |
Total operating expenses | 12,364 | 10,725 | 24,472 | 21,583 |
Loss from operations | (10,042) | (572) | (19,504) | (7,080) |
Loss from equity-method investment | (100) | (263) | (288) | |
Finance expense, net | (121) | (113) | (273) | (201) |
Net loss | $ (10,263) | $ (685) | $ (20,040) | $ (7,569) |
Net loss per share, basic and diluted | $ (0.55) | $ (0.07) | $ (1.20) | $ (0.74) |
Weighted-average shares outstanding, basic and diluted | 18,794 | 10,412 | 16,657 | 10,255 |
Comprehensive loss: | ||||
Net loss | $ (10,263) | $ (685) | $ (20,040) | $ (7,569) |
Comprehensive loss | $ (10,263) | $ (685) | $ (20,040) | $ (7,569) |
CONDENSED CONSOLIDATED STATEM_2
CONDENSED CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY - USD ($) shares in Thousands, $ in Thousands | Total | Ultragenyx [Member] | Cumulative Effect, Period of Adoption, Adjustment [Member] | Common Stock [Member] | Common Stock [Member]Ultragenyx [Member] | Additional Paid-In Capital [Member] | Additional Paid-In Capital [Member]Ultragenyx [Member] | Accumulated Deficit [Member] | Accumulated Deficit [Member]Cumulative Effect, Period of Adoption, Adjustment [Member] |
Balance at Dec. 31, 2018 | $ 13,642 | $ (803) | $ 214 | $ 58,302 | $ (44,874) | $ (803) | |||
Balance (in shares) at Dec. 31, 2018 | 10,762 | ||||||||
Accounting Standards Update [Extensible List] | us-gaap:AccountingStandardsUpdate201409Member | ||||||||
Net loss | $ (7,569) | (7,569) | |||||||
Treasury Stock (in shares) | (43) | ||||||||
Issuance of common stock upon exercise of stock options | 1 | 1 | |||||||
Issuance of common stock upon exercise of stock option (in shares) | 1 | ||||||||
Share-based compensation | 802 | 802 | |||||||
Redomiciliation share exchange | $ (203) | 203 | |||||||
Issuance of common stock to Ultragenyx and option, net of issuance costs | $ 15,545 | $ 2 | $ 15,543 | ||||||
Issuance of common stock to Ultragenyx and option, net of issuance costs (in shares) | 2,400 | ||||||||
Balance at Jun. 30, 2019 | 21,618 | $ 13 | 74,851 | (53,246) | |||||
Balance (in shares) at Jun. 30, 2019 | 13,120 | ||||||||
Balance at Mar. 31, 2019 | 6,354 | $ 214 | 58,701 | (52,561) | |||||
Balance (in shares) at Mar. 31, 2019 | 10,762 | ||||||||
Net loss | (685) | (685) | |||||||
Treasury Stock (in shares) | (43) | ||||||||
Issuance of common stock upon exercise of stock options | 1 | 1 | |||||||
Issuance of common stock upon exercise of stock option (in shares) | 1 | ||||||||
Share-based compensation | 403 | 403 | |||||||
Redomiciliation share exchange | $ (203) | 203 | |||||||
Issuance of common stock to Ultragenyx and option, net of issuance costs | 15,545 | $ 2 | 15,543 | ||||||
Issuance of common stock to Ultragenyx and option, net of issuance costs (in shares) | 2,400 | ||||||||
Balance at Jun. 30, 2019 | 21,618 | $ 13 | 74,851 | (53,246) | |||||
Balance (in shares) at Jun. 30, 2019 | 13,120 | ||||||||
Balance at Dec. 31, 2019 | 25,792 | $ 15 | 97,445 | (71,668) | |||||
Balance (in shares) at Dec. 31, 2019 | 15,138 | ||||||||
Net loss | (20,040) | (20,040) | |||||||
Issuance of common stock, net of issuance costs | 75,305 | $ 5 | 75,300 | ||||||
Issuance of common stock, net of issuance costs (in shares) | 4,735 | ||||||||
Issuance of common stock upon exercise of stock options | 816 | 816 | |||||||
Issuance of common stock upon exercise of stock option (in shares) | 137 | ||||||||
Share-based compensation | 1,950 | 1,950 | |||||||
Issuance of common stock to Ultragenyx and option, net of issuance costs | 9,600 | $ 1 | 9,599 | ||||||
Issuance of common stock to Ultragenyx and option, net of issuance costs (in shares) | 600 | ||||||||
Balance at Jun. 30, 2020 | 93,423 | $ 21 | 185,110 | (91,708) | |||||
Balance (in shares) at Jun. 30, 2020 | 20,610 | ||||||||
Balance at Mar. 31, 2020 | 16,982 | $ 15 | 98,412 | (81,445) | |||||
Balance (in shares) at Mar. 31, 2020 | 15,157 | ||||||||
Net loss | (10,263) | (10,263) | |||||||
Issuance of common stock, net of issuance costs | 75,305 | $ 5 | 75,300 | ||||||
Issuance of common stock, net of issuance costs (in shares) | 4,735 | ||||||||
Issuance of common stock upon exercise of stock options | 698 | 698 | |||||||
Issuance of common stock upon exercise of stock option (in shares) | 118 | ||||||||
Share-based compensation | 1,101 | 1,101 | |||||||
Issuance of common stock to Ultragenyx and option, net of issuance costs | $ 9,600 | $ 1 | $ 9,599 | ||||||
Issuance of common stock to Ultragenyx and option, net of issuance costs (in shares) | 600 | ||||||||
Balance at Jun. 30, 2020 | $ 93,423 | $ 21 | $ 185,110 | $ (91,708) | |||||
Balance (in shares) at Jun. 30, 2020 | 20,610 |
CONDENSED CONSOLIDATED STATEM_3
CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands | 6 Months Ended | |
Jun. 30, 2020 | Jun. 30, 2019 | |
OPERATING ACTIVITIES: | ||
Net loss | $ (20,040) | $ (7,569) |
Adjustments to reconcile net loss to net cash (used in) provided by operating activities: | ||
Depreciation and amortization | 394 | 349 |
Share-based compensation expense | 1,950 | 802 |
Loss from equity-method investment | 263 | 288 |
Other non-cash interest expense | 654 | 428 |
Changes in operating assets and liabilities | ||
Accounts receivable | (650) | (1,336) |
Prepaid expense and other assets | (2,302) | (1,043) |
Accounts payable | (1,442) | 773 |
Accrued liabilities | 3,619 | (1,536) |
Deferred revenue | (2,798) | 12,773 |
Net cash (used in) provided by operating activities | (20,352) | 3,929 |
INVESTING ACTIVITIES: | ||
Acquisition of property and equipment | (611) | (344) |
Net cash used in investing activities | (611) | (344) |
FINANCING ACTIVITIES: | ||
Proceeds from issuance of common stock, net of issuance costs | 75,305 | |
Proceeds from exercise of stock options | 816 | 1 |
Net cash provided by financing activities | 85,721 | 15,546 |
NET INCREASE IN CASH, CASH EQUIVALENTS AND RESTRICTED CASH | 64,758 | 19,131 |
Cash, cash equivalents and restricted cash at beginning of the period | 71,460 | 36,816 |
Cash, cash equivalents and restricted cash at end of the period | 136,218 | 55,947 |
Supplemental disclosure of cash flow information | ||
Cash paid for interest | 180 | 340 |
Non-cash investing activities | ||
Right-of-use asset obtained in exchange for lease liabilities | 674 | 5,868 |
Purchase of property and equipment in accounts payable | 44 | 16 |
Ultragenyx [Member] | ||
FINANCING ACTIVITIES: | ||
Proceeds from the issuance of common stock to Ultragenyx on option exercise | $ 9,600 | $ 15,545 |
Description of Business, Basis
Description of Business, Basis of Presentation and Summary of Significant Accounting Policies | 6 Months Ended |
Jun. 30, 2020 | |
Accounting Policies [Abstract] | |
Description of Business, Basis of Presentation and Summary of Significant Accounting Policies | Note 1. Description of Business, Basis of Presentation and Summary of Significant Accounting Policies Description of Business Arcturus Therapeutics Holdings Inc. (the “Company”) is a messenger RNA medicines company focused on significant opportunities within liver and respiratory rare diseases, and the development of infectious disease vaccines utilizing its Self-Transcribing and Replicating RNA (“STARR”) technology. In addition to the Company’s internal messenger RNA (“mRNA”) platform, its proprietary lipid nanoparticle delivery system, LUNAR, has the potential to enable multiple nucleic acid medicines. In April 2020, the Company became a clinical stage Company when it announced that its Investigational New Drug (“IND”) application for a Phase 1b study in patients with ornithine transcarbamylase (“OTC”) deficiency was deemed allowed to proceed by the U.S. Food and Drug Administration (“FDA”), and an additional Clinical Trial Application (“CTA”) for a Phase 1 study in healthy volunteers was approved by the New Zealand Medicines and Medical Devices Safety Authority. In March 2020, the Company was awarded a grant (the “Grant”) from the Singapore Economic Development Board to support the co-development of a potential COVID-19 vaccine with the Duke-NUS Medical School. The grant provides for up to S$14.0 million (approximately US$10 million using the exchange rate at the time the grant contract was entered into) in grants to support the development of the vaccine. A portion of the Grant will be paid by the Economic Development Board in advance and the remainder of the Grant will be paid to the Company upon the achievement of certain milestones related to the progress of the development of the vaccine, as set forth in the award agreement. The Company has agreed to pay Duke-NUS Medical School a royalty based on annual net sales of the vaccine in markets or jurisdictions outside of Singapore. In the Company and Duke-NUS Medical School announced that the CTA for COVID-19 vaccine candidate LUNAR-COV19 had been approved to proceed by the Singapore Health Sciences Authority ("HSA"). Basis of Presentation The financial statements for periods prior to June 17, 2019 Arcturus Therapeutics Ltd., Arcturus Therapeutics Ltd The accompanying condensed consolidated financial statements include the accounts of Arcturus Therapeutics Holdings Inc. and its subsidiaries and are unaudited. All intercompany accounts and transactions have been eliminated in consolidation. These condensed consolidated financial statements have been prepared in accordance with U.S. generally accepted accounting principles (“GAAP”) for interim financial information. Accordingly, they do not include all of the information and footnotes required by GAAP for complete financial statements. In management’s opinion, the accompanying condensed consolidated financial statements reflect all adjustments, consisting of normal recurring adjustments, considered necessary for a fair presentation of the results for the interim periods presented. Interim financial results are not necessarily indicative of results anticipated for the full year. These condensed consolidated financial statements should be read in conjunction with the audited financial statements and footnotes included in the Company’s Annual Report on Form 10-K for the year ended December 31, 2019. These condensed consolidated financial statements are prepared in accordance with GAAP, which requires management to make estimates and assumptions regarding the valuation of certain debt and equity instruments, the disclosure of contingent assets and liabilities at the date of the financial statements and Liquidity The Company’s activities since inception have consisted principally of performing research and development activities, general and administration activities, and raising capital. The Company’s activities are subject to significant risks and uncertainties, including failing to secure additional funding before the Company achieves sustainable revenues and profit from operations. The Company is a clinical-stage bioscience company that is dependent on obtaining external equity and debt financings to fund its operations. Historically, the Company’s primary sources of financing have been through the sale of its securities, through issuance of debt and through collaboration agreements. As mentioned above, the Company was recently awarded a grant from the Singapore Economic Development Board of up to approximately $10.0 million to support the co-development of a potential COVID-19 vaccine with the Duke-NUS Medical School, approximately $5.0 million of which was awarded during the quarter ended March 31, 2020 and subsequently received in April 2020. Additionally, in April 2020 the Company completed an underwritten public offering of 4,735,297 shares of common stock (including the underwriters’ overallotment option) at a price of $17.00 per share. The Company received net proceeds of approximately $75.5 million in the offering. In May 2020, Ultragenyx exercised its option to purchase 600,000 shares of the Company’s common stock at $16 per share. The Company received proceeds of $9.6 million as a result of the option exercise. In July 2020 the Company completed an additional underwritten public offering of 4,243,395 shares of common stock (including the underwriters’ overallotment option) at a price of $53.00 per share. The Company received net proceeds of approximately $186.3 million in the offering. Segment Information Operating segments are identified as components of an enterprise about which separate discrete financial information is available for evaluation by the chief operating decision-maker in making decisions regarding resource allocation and assessing performance. The Company and its chief operating decision-maker view the Company’s operations and manage its business in one operating segment, which is the research and development of medical applications for the Company’s nucleic acid-focused technology. Revenue Recognition Effective January 1, 2019, the Company adopted Accounting Standards Update (“ASU”) 2014-09, Revenue from Contracts with Customers (Topic 606) (“Topic 606”), The terms of the Company’s collaborative research and development agreements include license fees, upfront payments, milestone payments, and reimbursement for research and development activities, option exercise fees, and royalties on sales of commercialized products. Arrangements that include upfront payments are recorded as deferred revenue upon receipt or when due and may require deferral of revenue recognition to a future period until the Company performs obligations under these arrangements. The event-based milestone payments represent variable consideration, and the Company uses the most likely amount method to estimate this variable consideration because the Company will either receive the milestone payment or will not, which makes the potential milestone payment a binary event. The most likely amount method requires the Company to determine the likelihood of earning the milestone payment. Given the high degree of uncertainty around achievement of these milestones, the Company determines the milestone amounts to be fully constrained and does not recognize revenue until the uncertainty associated with these payments is resolved. The Company will recognize revenue from sales-based royalty payments when or as the sales occur. The Company will re-evaluate the transaction price in each reporting period as uncertain events are resolved and other changes in circumstances occur. A performance obligation is a promise in a contract to transfer a distinct good or service to the collaborative partner and is the unit of account in Topic 606. A contract’s transaction price is allocated to each distinct performance obligation based on relative standalone selling price and recognized as revenue when, or as, the performance obligation is satisfied. See “Note 2, Collaboration Revenue” Leases In February 2016, the FASB issued ASU 2016-02, Leases (Topic 842), which requires lessees to recognize most leases on the balance sheet as lease liabilities with corresponding right-of-use assets and to disclose key information about leasing arrangements. The Company adopted Topic 842 on its effective date in the first quarter of 2019 using a modified retrospective approach. The Company elected the available package of practical expedients upon adoption, which allowed it to carry forward historical assessments of whether existing agreements contained a lease and the classification of existing operating leases. See “Note 8, Commitments and Contingences” Research and Development, Net Research and development costs are expensed as incurred. These expenses result from the Company’s independent research and development efforts as well as efforts associated with collaboration arrangements. Research and development costs include salaries and personnel-related costs, consulting fees, fees paid for contract research and manufacturing services, the costs of laboratory supplies, equipment and facilities, preclinical studies and other external costs are shown net of any grants. Statement of Cash Flows The following table provides a reconciliation of cash and cash equivalents and restricted cash reported within the condensed consolidated balance sheet to the total of the same such amounts shown in the condensed consolidated statement of cash flows: (in thousands) June 30, 2020 June 30, 2019 Cash and cash equivalents $ 136,111 $ 55,840 Non-current restricted cash 107 107 Total cash, cash equivalents and restricted cash shown in the statement of cash flows $ 136,218 $ 55,947 Net Loss per Share Basic net loss per share is calculated by dividing the net loss by the weighted-average number of shares of common stock outstanding for the period, without consideration for common stock equivalents. Diluted net loss per share is calculated by dividing the net loss by the weighted-average number of shares of common stock and dilutive common stock equivalents outstanding for the period determined using the treas ury-stock method. Dilutive shares of common stock are comprised of stock options. No dividends were declared or paid during the reported periods. |
Collaboration Revenue
Collaboration Revenue | 6 Months Ended |
Jun. 30, 2020 | |
Collaboration Agreements [Abstract] | |
Collaboration Revenue | Note 2. Collaboration Revenue The Company has entered into license agreements and collaborative research and development arrangements with pharmaceutical and biotechnology companies. Under these arrangements, the Company is entitled to receive license fees, upfront payments, milestone payments if and when certain research and development milestones or technology transfer milestones are achieved, royalties on approved product sales and reimbursement for research and development activities. The Company’s costs of performing these services are included within research and development expenses. The Company’s milestone payments are typically defined by achievement of certain preclinical, clinical, and commercial success criteria. Preclinical milestones may include in vivo proof of concept in disease animal models, lead candidate identification, and completion of IND-enabling toxicology studies. Clinical milestones may, for example, include successful enrollment of the first patient in or completion of Phase I, II, and III clinical trials, and commercial milestones are often tiered based on net or aggregate sale amounts. The Company cannot guarantee the achievement of these milestones due to risks associated with preclinical and clinical activities required for development of nucleic acid medicine-based therapeutics. The following table presents changes during the six months ended June 30, 2020 in the balances of contract assets, including receivables from collaborative partners, and contract liabilities, including deferred revenue, as compared to what was disclosed in the Company’s 2019 Annual Report. (in thousands) Contract Assets BALANCE - December 31, 2019 $ 2,179 Additions for revenue recognized from billings 2,171 Deductions for cash collections (1,521 ) BALANCE – June 30, 2020 $ 2,829 (in thousands) Contract Liabilities BALANCE - December 31, 2019 $ 23,579 Additions for advanced billings 2,171 Deductions for promised services provided in current period (4,969 ) BALANCE – June 30, 2020 $ 20,781 The following table summarizes the Company’s collaboration revenues for the periods indicated (in thousands). For the Three Months Ended June 30, For the Six Months Ended June 30, (Dollars in thousands) 2020 2019 2020 2019 Collaboration Partner – Janssen $ 693 $ 622 $ 1,590 $ 1,135 Collaboration Partner – Ultragenyx 913 2,544 1,824 3,932 Collaboration Partner – CureVac 231 3,409 540 5,303 Collaboration Partner – Other 485 3,578 1,014 4,133 Total collaboration revenue $ 2,322 $ 10,153 $ 4,968 $ 14,503 The following paragraphs provide information regarding the nature and purpose of the Company’s most significant collaboration arrangements. Collaboration Partner – Janssen In October 2017, the Company entered into a research collaboration and license agreement with Janssen (the “2017 Agreement”). The 2017 Agreement allocated discovery, development, funding obligations, and ownership of related intellectual property among the Company and Janssen Pharmaceuticals, Inc. (“Janssen”). The Company received an upfront payment of $7.7 million and may receive preclinical, development and sales milestone payments of $56.5 million, as well as royalty payments on any future licensed product sales. Janssen began reimbursing the Company for research costs during the first quarter of 2019 upon the completion of the first of three research periods. Janssen may also pay option exercise fees within the $1.0 million to $5.0 million range per target. Janssen will pay royalties on annual net sales of licensed products in the low to mid-single digits range, subject to reduction on a country-by-country and licensed-product-by-licensed-product basis and subject to certain events, such as expiration of program patents. In addition, the 2017 Agreement includes an exclusivity period. In evaluating the 2017 Agreement in accordance with ASC Topic 606, the Company concluded that the contract counterparty, Janssen, is a customer. The Company identified the following promised goods/services as of the inception of the Agreement: (i) research services, (ii) license to use Arcturus technology and (iii) participation in the Joint Research Committee. The Company concluded that the promised goods/services are incapable of being distinct and consequently do not have any value on a standalone basis. Accordingly, they are determined to represent a single performance obligation. The Company concluded that Janssen’s options to select additional collaboration targets and to license rights to selected targets are not priced at a discount and therefore do not represent performance obligations for which the transaction price would be allocated. As of June 30, 2020, the remaining transaction price, consisting of upfront consideration received and budgeted reimbursable out-of-pocket costs, is expected to be recognized using an input method over the remaining research period of 27 months. None of the development and commercialization milestones were included in the transaction price, as all milestone amounts were not estimated to be met, are outside the control of the Company and contingent upon success in future clinical trials and the collaborator’s efforts. Any consideration related to sales-based royalties will be recognized when the related sales occur, provided that the reported sales are reliably measurable, and the Company has no remaining promised goods/services, as such sales were determined to relate predominantly to the license granted to Janssen and therefore have also been excluded from the transaction price. Total deferred revenue as of June 30, 2020 and December 31, 2019 for Janssen was $6.0 million and $5.9 million, respectively. Collaboration Partner – Ultragenyx In October 2015 the Company entered into a research collaboration and license agreement with Ultragenyx (the “Ultragenyx Agreement”), whereby Arcturus granted to Ultragenyx a co-exclusive license under Arcturus technology and shall be in effect only during the reserve target exclusivity term as discussed in the following paragraphs. This collaboration agreement was amended in 2017, 2018 and during the second quarter of 2019. During the initial phase of the collaboration, the Company will design and optimize therapeutics for certain rare disease targets. Ultragenyx has the option under the Ultragenyx Agreement to add additional rare disease targets during the collaborative development period. Additionally, during the collaborative development period, the Company will participate with Ultragenyx in a joint steering committee. The Ultragenyx Agreement also includes an initial exclusivity period with an option to extend this period. As part of the Ultragenyx Agreement and related amendments, Ultragenyx has paid $27.9 million in upfront fees, exclusivity extension fees and additional consideration. Ultragenyx also reimburses the Company for all internal and external development costs incurred. Pursuant to the Ultragenyx Agreement, Ultragenyx is required to make additional payments upon exercise of the Ultragenyx expansion option or exclusivity extension (if any) and if Ultragenyx achieves certain, clinical, regulatory and sales milestones, then the Company is eligible to receive royalty payments $0.5 million to $1.5 million. The current potential development, regulatory and commercial milestone payments for the existing development targets as of June 30, 2020 are $138.0 million. Ultragenyx will pay royalties as a single-digit percentage of net sales on a product-by-product and country-by-country basis during the applicable royalty term. As of June 30, 2020, Ultragenyx has not yet reached the clinical phase of the contract. On June 18, 2019, Arcturus and Ultragenyx amended the collaboration agreement for a third time (“Amendment 3”). As part of Amendment 3, the total number of targets was increased from 10 to 12, and reserve targets will be exclusively reserved for Ultragenyx with no fees for four years after execution of the amendment. An equity component was also added as part of Amendment 3 wherein Ultragenyx purchased 2.4 million shares of common stock at a premium price. Along with the equity purchase, Ultragenyx received an option to purchase 0.6 million additional shares of common stock at $16 per share (Note 6). In May 2020, the option was exercised. The consideration received from Ultragenyx as a result of Amendment 3 was equal to $30.0 million and was comprised of a $24.0 million common stock purchase and a $6.0 million upfront payment. Specifically for Amendment 3, management determined the transaction price to be $14.4 million. See further discussion below regarding determining the transaction price. Management determined the fair value of the premium received by using the opening stock price subsequent to execution of Amendment 3 and applying a lack of marketability discount as the shares received by Ultragenyx were initially restricted for up to two years. Pursuant to the terms of the equity purchase agreement between the Company and Ultragenyx, the transfer restrictions will terminate on November 20, 2020 as a result of the purchase of the 0.6 million option shares. In evaluating the Ultragenyx agreement in accordance with ASC Topic 606, the Company concluded that the contract counterparty, Ultragenyx, is a customer. The Company has identified the following promised goods/services as part of the initial agreement and subsequent amendments: (i) research services, (ii) license to use Arcturus technology, (iii) exclusivity and (iv) participation in the Joint Steering Committee. The Company concluded that the promised goods/services are incapable of being distinct and consequently do not have any value on a standalone basis. Accordingly, they are determined to represent a single performance obligation. The Company concluded that Ultragenyx’s options to extend exclusivity and options to select additional collaboration targets and to license rights to selected targets are not priced at a discount and therefore do not represent performance obligations for which the transaction price would be allocated. At June 30, 2020, the transaction price included the upfront consideration received, exclusivity extension payments and additional consideration received pursuant to Amendment 3. The Company recognizes the reimbursement of labor and expenses as costs are incurred and none of the development and commercialization milestones were included in the transaction price, as all milestone amounts were fully constrained. As part of its evaluation of the constraint, the Company considered numerous factors, including that the consideration is outside the control of the Company and contingent upon success in future clinical trials, approval from the Food and Drug Administration and the collaborator’s efforts. Any consideration related to sales-based royalties will be recognized when the related sales occur as they are constrained, provided that the reported sales are reliably measurable and the Company has no remaining promised goods/services, as such sales were determined to relate predominantly to the license granted to Ultragenyx and therefore have also been excluded from the transaction price. Amendment 3 was deemed a contract modification and accounted for as part of the original Ultragenyx Agreement and the Company recorded a cumulative catch-up adjustment of $1.1 million on the modification date. The transaction price will be recognized to revenue on a straight-line basis using an input method over the 4-year reserve target exclusivity period. The reserve target exclusivity period represents the timing over which promised goods/services Collaboration Partner – CureVac In January 2018, the Company entered into a Development and Option Agreement with CureVac, (the “Development and Option Agreement”). Under the terms of the Development and Option Agreement, the parties agreed to conduct joint preclinical development programs once CureVac makes a payment to pull down a target on the basis of which CureVac is granted options for taking a license on pre-agreed license terms to develop and commercialize certain products incorporating the Company’s patents and know-how related to delivery technology (the LUNAR platform) (the “Arcturus Delivery Technology”), and CureVac patents and know-how related to mRNA technology. Subject to certain restrictions, the parties will have an undivided one-half interest in the patents and know-how developed jointly by the parties during the course of the Development and Option Agreement. Pursuant to the terms of the Development and Option Agreement, CureVac will have a number of target options to co-develop from a reserved target list to enter into licenses under the Arcturus Delivery Technology with respect to the development, manufacture and commercialization of licensed products (which can include products identified for development by the Company, unless the Company is permitted by the terms of the Development and Option Agreement to place such products on a restricted list). A separate notice and fee will be required for each license agreement. If the target to which the license agreement relates is chosen by the parties for co-development under the Co-Development Agreement (as defined below and discussed in the following paragraph) the license agreement will terminate as such programs will be covered under the Co-Development Agreement discussed below, and therefore CureVac will be given a credit for any exercise fees, milestone payments already paid and all other payments made in relation to the license agreement towards future such payments incurred with respect to future licenses under the Arcturus Delivery Technology. Prior to expiration of the initial term of 8 years (which was subsequently amended, as discussed below), the Agreement also includes an option to extend the term on an annual basis for up to 3 years, subject to payment by CureVac to Arcturus of a non-refundable annual extension fee. The agreement included potential milestone payments for selected targets from CureVac to the Company. The current potential milestone payments for the remaining targets as of June 30, 2020 are $14.0 million for rare disease targets and $23.0 million for non-rare disease targets. CureVac will pay royalties as a percentage of net sales on a product-by-product and country-by-country basis during the applicable royalty term in the low single-digit range. As of June 30, 2020, CureVac has not yet reached the clinical phase of the contract. Pursuant to a May 2018 amendment to the Development and Option Agreement (as amended and restated on September 28, 2018), the Company increased the number of targets available to CureVac under the Development and Option Agreement and agreed upon the license forms to be executed upon selection of the targets by CureVac. Concurrently with the Development and Option Agreement, the Company entered into a Co-Development and Co-Commercialization Agreement (the “Co-Development Agreement”) which the Company considered a combined contract with the Development and Option Agreement for purposes of revenue recognition. However, on February 11, 2019, the Company announced the termination of the obligations of CureVac for the preclinical development of ARCT-810, effective as of August 4, 2019 and the re-assumption by the Company of the worldwide rights thereto. As a result, On July 26, 2019, the Company entered into an amendment (“CureVac Amendment”) to its Development and Option Agreement with CureVac (as amended, the “Development and Option Agreement”), pursuant to which the Company and CureVac agreed to shorten the time period during which CureVac may select potential targets to be licensed from the Company from eight years to four years, and to reduce the overall number of maximum targets to be reserved and licensed. In connection with the July 2019 CureVac Amendment, the Company and CureVac also entered into a Termination Agreement (the “Termination Agreement”) terminating the January 1, 2018 Co-Development Agreement between the Company and CureVac. Pursuant to the Termination Agreement CureVac agreed to make a one-time payment to Arcturus in the amount of $4.0 million, which was made in July 2019. In evaluating the CureVac Development and Option Agreement and Co-Development Agreement in accordance with ASC Topic 606, the Company concluded that the contract counterparty, CureVac, is a customer. The Company has identified the following promised goods/services as part of the initial agreement with CureVac and subsequent amendments: (i) research services, (ii) license to use Arcturus technology, (iii) exclusivity and (iv) participation in the Joint Steering Committee. The Company concluded that the promised goods/services are incapable of being distinct At June 30, 2020, the transaction price included the upfront consideration received. The Company recognizes the reimbursement of labor and expenses as costs are incurred and none of the development and commercialization milestones were included in the transaction price, as all milestone amounts were fully constrained. As part of its evaluation of the constraint, the Company considered numerous factors, including that receipt of the milestones is outside the control of the Company and contingent upon success in future clinical trials and the collaborator’s efforts. Any consideration related to sales-based royalties will be recognized when the related sales occur as they are constrained, provided that the reported sales are reliably measurable and the Company has no remaining promised goods/services, as such sales were determined to relate predominantly to the license granted to CureVac and therefore have also been excluded from the transaction price. For the three months ended June 30, 2020, no adjustments were made to the transaction price. The upfront consideration of $5.0 million was recorded as deferred revenue in the Company’s balance sheet upon receipt and is currently being recognized as revenue on a straight-line basis using an input method over the remaining 37 month contractual term as of June 30, 2020. As a result of Amendment 3, the Company recorded a cumulative catch up adjustment of $0.4 million on the modification date, July 26, 2019. Total deferred revenue as of June 30, 2020 and December 31, 2019 for CureVac was $2.8 million and $3.2 million, respectively. No adjustment was necessary upon adoption of Topic 606. Other Collaboration Revenue The remaining revenue from smaller collaboration agreements primarily relates to the agreements with Millennium Pharmaceuticals, Inc., a wholly owned subsidiary of Takeda Pharmaceutical Company Limited (“Takeda”) and Synthetic Genomics, Inc. (“SGI”). Under the agreement with Takeda, the Company recognized $0.5 million during the first two quarters of 2020 which relates to the amortization of an upfront payment for research and development activities. The current agreement with Takeda was entered into on March 18, 2019 and is expected to be completed by the end of 2020. Under the agreement with SGI, the Company recognized $0.3 million during the second quarter of 2020 related to sublicensed technology. |
Fair Value Measurements
Fair Value Measurements | 6 Months Ended |
Jun. 30, 2019 | |
Fair Value Disclosures [Abstract] | |
Fair Value Measurements | Note 3. Fair Value Measurements The Company establishes the fair value of its assets and liabilities using the price that would be received to sell an asset or paid to transfer a liability in an orderly transaction between market participants at the measurement date. The Company establishes a fair value hierarchy based on the inputs used to measure fair value. The three levels of the fair value hierarchy are as follows: Level 1: Quoted prices in active markets for identical assets or liabilities. Level 2: Inputs, other than the quoted prices in active markets, that are observable either directly or indirectly. Level 3: Unobservable inputs in which little or no market data exists and are therefore determined using estimates and assumptions developed by the Company, which reflect those that a market participant would use. The carrying value of cash, restricted cash, accounts receivable, accounts payable, and accrued liabilities approximate their respective fair values due to their relative short maturities. The carrying amounts of long-term debt for the amount drawn on the Company’s debt facility approximates fair value as the interest rate is variable and reflects current market rates. As of June 30, 2020 and December 31, 2019, all assets measured at fair value on a recurring basis consisted of cash equivalents, money market funds, which were classified within Level 1 of the fair value hierarchy. The fair value of these financial instruments was measured based on quoted prices. |
Balance Sheet Details
Balance Sheet Details | 6 Months Ended |
Jun. 30, 2020 | |
Balance Sheet Related Disclosures [Abstract] | |
Balance Sheet Details | Note 4 Property and equipment, net consisted of the following: (in thousands) June 30, 2020 December 31, 2019 Research equipment $ 4,282 $ 3,658 Computers and software 285 271 Office equipment and furniture 574 561 Leasehold improvements 44 40 Total 5,185 4,530 Less accumulated depreciation and amortization (2,575 ) (2,181 ) Property and equipment, net $ 2,610 $ 2,349 Depreciation and amortization expense was $0.2 million and $0.2 million Accrued liabilities consisted of the following as of June 30, 2020 and December 31, 2019: (in thousands) June 30, 2020 December 31, 2019 Accrued compensation $ 2,234 $ 1,608 Cystic Fibrosis Foundation Liability 3,010 1,949 Singapore Economic Development Board Liability 672 — Current portion of operating lease liability 1,337 827 Clinical Accruals 299 — Other accrued research and development expenses 4,331 2,750 Total $ 11,883 $ 7,134 |
Debt
Debt | 6 Months Ended |
Jun. 30, 2020 | |
Debt Disclosure [Abstract] | |
Debt | Note 5. Debt Long-term debt with Western Alliance Bank On October 12, 2018, the Company entered into a Loan and Security Agreement with Western Alliance Bank (the “Bank”), whereby the Company received $10.0 million under a long-term debt agreement (the “Loan”). The Loan is collateralized by all of the assets of the Company, excluding intellectual property, which is subject to a negative pledge. The Loan contains customary conditions of borrowing, events of default and covenants, including covenants that restrict the Company’s ability to dispose of assets, merge with or acquire other entities, incur indebtedness and make distributions to holders of the Company’s capital stock. In addition, the Company is required to maintain at least 100% of its consolidated, unrestricted cash, or $15.0 million, whichever is lower, with the Bank. On October 30, 2019, the Company and the Bank entered into a Third Amendment (the “Third Amendment”) to the Loan and Security Agreement dated as of October 12, 2018 (as amended, the “Loan Agreement”). Pursuant to the amendment, the Bank agreed to make a term loan to the Company on October 30, 2019, in the amount of $15.0 million (the “Term Loan”). The resulting net increase in the indebtedness of the Company was $5.0 million. The Term Loan bears interest at a floating rate ranging from 1.25% to 2.75% above the prime rate. The amendment further provides that the Term Loan has a maturity date of October 30, 2023. The Company shall make monthly payments of interest only until the interest-only end date of October 1, 2021. The Company paid a loan origination fee of $54,000 which was recorded as a debt discount along with the remaining loan origination fee from the Loan and is being accreted over the term of the Term Loan. In addition, the Company is required to pay a fee of $525,000 upon certain change of control events. The Term Loan may be prepaid in full at any time, provided that a prepayment fee is required to be paid by the Company upon prepayment. The prepayment fee ranges from 0.50% to 2.00% of the prepaid principal amount depending upon the date on which the prepayment is made. In connection with the Third Amendment, the Company guaranteed the obligations under the Loan Agreement and pledged substantially all of its assets as security under the Loan Agreement. The Term Loan also includes covenants which includes the Company’s submission of a clinical candidate for IND application made to the U.S. Food and Drug Administration by May 31, 2020 and have it accepted by June 30, 2020. This covenant has been satisfied. Upon maturity or prepayment (as previously discussed), the Company will be required to pay a 2% fee as a result of the FDA’s approval to proceed with the Company’s the LUNAR-OTC (ARCT-810) program based on its IND submission. Such fee is accreted to the debt balance using the effective interest method over the term of the Loan Agreement. Should an event of default occur, including the occurrence of a material adverse effect, the Company could be liable for immediate repayment of all obligations under the Loan Agreement. As of June 30, 2020, the Company was in compliance with all covenants under the Loan Agreement. Principal payments, including the final payment due at repayment, on the long-term debt for fiscal years 2021, 2022 and 2023 are $1.3 million, $7.5 million and $6.7 million, respectively, with no principal payments due in 2020. The Company recognized interest expense related to its long-term debt of $0.2 million and $0.5 million for the three and six months ended June 30, 2020, respectively, and $0.2 million and $0.4 million for the three and six months ended June 30, 2019, respectively. |
Stockholders' Equity
Stockholders' Equity | 6 Months Ended |
Jun. 30, 2020 | |
Stockholders Equity Note [Abstract] | |
Stockholders' Equity | Note 6. Stockholders’ Equity Restricted Common Shares In March 2013, the founders of the Company purchased 2,783,686 shares of common stock for $0.0068 per share. Of the shares purchased, 1,538,353 were subject to a repurchase option whereby the Company has an option for two months after date of termination of service to repurchase any or all of the unvested shares at the original purchase price per share. The repurchase option shall be deemed to be automatically exercised by the Company as of the end of the two-month period unless the Company notifies the purchaser that it does not intend to exercise its option. The shares will be vested (1) 25% after obtaining suitable siRNA license; (2) 25% after in vivo 622,667 Net Loss per Share Dilutive securities that were not included in the calculation of diluted net loss per share for the three and six months ended June 30, 2020 as they were anti-dilutive totaled 1,505,244 and 903,949, respectively, and 93,407 and 80,585 for the three and six months ended June 30, 2019, respectively. For the three and six months ended June 30, 2020 and 2019, the calculation of the weighted-average number of shares outstanding excludes unvested restricted shares of common stock of 311,333. |
Share-Based Compensation
Share-Based Compensation | 6 Months Ended |
Jun. 30, 2020 | |
Disclosure Of Compensation Related Costs Sharebased Payments [Abstract] | |
Share-Based Compensation | Note 7. Share-Based Compensation In June 2019, the Company adopted the 2019 Omnibus Equity Incentive Plan (“2019 Plan”), which was ratified by stockholders at the Company’s 2019 annual meeting. Under the 2019 Plan, the Company is authorized to issue up to a maximum of 2,600,000 shares of common stock pursuant to the exercise of incentive stock options or other awards provided for therein. In June 2020, the stockholders of the Company approved an increase to the number of shares authorized for use in making awards under the 2019 Plan by 3,150,000 shares to 5,750,000. Accordingly, as of June 30, 2020, a total of 2,616,340 shares remain available for future issuance under the 2019 Plan. In June 2020, the stockholders of the Company approved the 2020 Employee Stock Purchase Plan (“2020 Plan”) which provides for 600,000 shares of Company common stock reserved for future issuance. The first accumulation period under the 2020 Plan will commence in August 2020. Stock Options Share-based compensation expenses included in the Company’s condensed statements of operations and comprehensive loss for the three and six months ended June 30, 2020 and 2019 were: For the Three Months Ended June 30, For the Six Months Ended June 30, (in thousands) 2020 2019 2020 2019 Research and development $ 396 $ 157 $ 662 $ 308 General and administrative 705 246 1,288 494 Total $ 1,101 $ 403 $ 1,950 $ 802 |
Income Taxes
Income Taxes | 6 Months Ended |
Jun. 30, 2020 | |
Income Tax Disclosure [Abstract] | |
Income Taxes | Note 8. Income Taxes The Company is subject to taxation in the United States and various states. The Company computes its quarterly income tax provision by using a forecasted annual effective tax rate and adjusts for any discrete items arising during the quarter. The primary difference between the effective tax rate and the federal statutory tax rate relates to the valuation allowances on the Company’s net operating losses. No tax benefit was provided for losses incurred in the United States because those losses are offset by a full valuation allowance. For the three and six months ended June 30, 2020, the Company recorded income tax expense of $0 million. No tax benefit was provided for losses incurred in United States because those losses are offset by a full valuation allowance. On March 27, 2020, the United States enacted the Coronavirus Aid, Relief and Economic Security Act (CARES Act). The Cares Act is an emergency economic stimulus package that includes spending and tax breaks to strengthen the United States economy and fund a nationwide effort to curtail the effect of COVID-19. While the CARES Act provides sweeping tax changes in response to the COVID-19 pandemic, some of the more significant provisions which are expected to impact the Company’s financial statements include removal of certain limitations on utilization of net operating losses, increasing the loss carryback period for certain losses to five years, and increasing the ability to deduct interest expense, as well as amending certain provisions of the previously enacted Tax Cuts and Jobs Act. For the quarter ended March 31, 2020 the Company estimated that the impact of the CARES Act will be immaterial to its tax position. Due to the recent enactment of the CARES Act, the Company will continue to analyze the impact that the CARES Act will have in subsequent quarters on its financial position, results of operations or cash flows . |
Commitments and Contingencies
Commitments and Contingencies | 6 Months Ended |
Jun. 30, 2020 | |
Commitments And Contingencies Disclosure [Abstract] | |
Commitments and Contingencies | Note 9. Commitments and Contingencies COVID-19 Vaccine Development On March 4, 2020, the Company was awarded a grant (the “Grant”) from the Singapore Economic Development Board to support the co-development of a potential COVID-19 vaccine with the Duke-NUS Medical School. The Grant provides for up to S$14.0 million (approximately US$10.0 million using the March 2, 2020 exchange rate) in grants to support the development of the vaccine. A portion of the Grant will be paid by the Economic Development Board in advance and the remainder of the Grant will be paid to the Company upon the achievement of certain milestones related to the progress of the development of the vaccine, as set forth in the award agreement. The funds received will be recognized as contra research and development expense in proportion to the percentage covered by the Economic Development Board of the overall budget. The Company is liable for certain expenses during the program. For the three and six months ended June 30, 2020, the Company recognized $3.8 million and $4.3 million of contra expense, respectively, with $0.7 million remaining in accrued expenses. Cystic Fibrosis Foundation Agreement On August 1, 2019, the Company amended its Development Program Letter Agreement, dated May 16, 2017 and as amended July 13, 2018, with the Cystic Fibrosis Foundation (“CFF”). Pursuant to the amendment, (i) CFF increased the amount it will award to advance LUNAR-CF to $15.0 million from approximately $3.2 million, (ii) the Company will provide $5.0 million in matching funds for remaining budgeted costs and (iii) the related disbursement schedule from CFF to Arcturus was modified such that (a) $4.0 million was disbursed upon execution of the CFF Amendment, (b) $2.0 million will be disbursed within 30 days of the first day of each of January, April, July and October 2020 upon Arcturus invoicing CFF to meet project goals, and (c) the last payment of $3.0 million less the prior award previously paid out, equaling approximately $2.3 million, will be disbursed upon Arcturus Therapeutics, Inc. invoicing CFF to meet good manufacturing practices and opening an Investigational New Drug (“IND”) application. The funds received from CFF will be recognized as contra research and development expense in proportion to the percentage covered by CFF of the overall budget. For the three and six months ended June 30, 2020, the Company recognized $0.9 million and $2.9 million of contra expense, respectively, with $3.0 million remaining in accrued expenses. No contra research and development expense was recognized during the six months ended June 30, 2019. Leases In October 2017, the Company entered into a non-cancellable operating lease agreement for office space adjacent to its previously occupied headquarters. The commencement of the lease began in March 2018 and the lease extends for approximately 84 months from the commencement date with a remaining lease term through March 2025. Monthly rental payments are due under the lease and there are escalating rent payments during the term of the lease. The Company is also responsible for its proportional share of operating expenses of the building and common areas. In conjunction with the new lease, the Company received free rent for four months and received a tenant improvement allowance of $74,000. The lease may be extended for one five-year period at the then current market rate with annual escalations; however, the Company deemed the extension option not reasonably certain to be exercised and therefore excluded the option from the lease terms. The Company entered into an irrevocable standby letter of credit with the landlord for a security deposit of $96,000 upon executing the lease which is included (along with additional funds required to secure the letter of credit) in the balance of non-current restricted cash. In February 2020, the Company entered into a non-cancellable operating lease agreement for office space near its current headquarters. The lease extends for 13 months from the commencement date. In conjunction with the new lease, the Company received free rent for one month. The lease may be extended for one twelve-month period; however, the Company deemed the extension option not reasonably certain to be exercised and therefore excluded the option from the lease terms Operating lease right-of-use asset and liability on the condensed consolidated balance sheets represent the present value of remaining lease payments over the remaining lease terms. The Company does not allocate lease payments to non-lease components; therefore, payments for common-area-maintenance and administrative services are not included in the operating lease right-of-use asset and liability. The Company uses its incremental borrowing rate to calculate the present value of the lease payments, as the implicit rate in the lease is not readily determinable. As of June 30, 2020, the payments of the operating lease liability were as follows: (in thousands) Remaining Lease Payments 2020 (remaining) $ 992 2021 1,427 2022 1,349 2023 1,390 2024 1,432 Thereafter 314 Total remaining lease payments 6,904 Less: imputed interest (1,173 ) Total operating lease liabilities $ 5,731 Weighted-average remaining lease term 4.5 years Weighted-average discount rate 8.4 % Operating lease costs consist of the fixed lease payments included in operating lease liability and are recorded on a straight-line basis over the lease terms. Operating lease costs were $0.5 million and $0.9 million for the three and six months ended June 30, 2020, respectively, and $0.3 million and $0.6 million for the three and six months ended June 30, 2019, respectively. |
Related Party Transactions
Related Party Transactions | 6 Months Ended |
Jun. 30, 2020 | |
Related Party Transactions [Abstract] | |
Related Party Transactions | Note 10. Related Party Transactions Ultragenyx On June 17, 2019, Arcturus and Ultragenyx executed Amendment 3 to the Ultragenyx Agreement. Pursuant to the amended Ultragenyx Agreement, the Company also granted Ultragenyx a two-year option (the “Option”) to purchase up to 600,000 additional shares of common stock at a price of $16.00 per share (the “Additional Shares”). Ultragenyx exercised the Option in May 2020 . Equity-Method Investment In June 2018, the Company completed the sale of its intangible asset related to the ADAIR technology. Pursuant to the asset purchase agreement for ADAIR, the Company received a 30% ownership interest in the common stock of a privately held company in consideration for the sale of the ADAIR technology. The Company has no requirement to invest further in this private company. During the third quarter of 2019, the equity-method investee issued shares of its common stock at a share price greater than the initial investment which resulted in the Company recording a gain in its equity-method investment. The gain has been offset by additional losses incurred by the equity-method investee and calculated on a lag. For the three and six months ended June 30, 2020, the Company recorded losses of $0.1 million and $0.3 million, respectively. Subsequent to the equity-method investee issuing shares of its common stock, the Company’s ownership was reduced to 19%. As the Company continues to have the ability to exercise significant influence over the operating and financial policies of the investee, the Company will continue to account for the investment as an equity-method investment. |
Subsequent Events
Subsequent Events | 6 Months Ended |
Jun. 30, 2020 | |
Subsequent Events [Abstract] | |
Subsequent Events | Note 11. Subsequent Events Agreement with Israeli Ministry of Health On July 23, 2020, the Company announced a binding term sheet with the Israeli Ministry of Health to supply the Company’s COVID-19 vaccine candidate, LUNAR-COV19. The parties intend to finalize a comprehensive supply agreement within 30 days of the announcement. LUNAR-COV19 CTA acceptance See discussion of the LUNAR-COV19 CTA acceptance at Note 1. Underwritten Public Offering of Common Stock See discussion of underwritten public offering of common stock and full exercise of the underwriters’ overallotment option at Note 1. Chief Legal Officer On August 6, 2020, the Company announced the appointment of Lance Kurata as Chief Legal Officer, effective August 10, 2020. |
Description of Business, Basi_2
Description of Business, Basis of Presentation and Summary of Significant Accounting Policies (Policies) | 6 Months Ended |
Jun. 30, 2020 | |
Accounting Policies [Abstract] | |
Basis of Presentation | Basis of Presentation The financial statements for periods prior to June 17, 2019 Arcturus Therapeutics Ltd., Arcturus Therapeutics Ltd The accompanying condensed consolidated financial statements include the accounts of Arcturus Therapeutics Holdings Inc. and its subsidiaries and are unaudited. All intercompany accounts and transactions have been eliminated in consolidation. These condensed consolidated financial statements have been prepared in accordance with U.S. generally accepted accounting principles (“GAAP”) for interim financial information. Accordingly, they do not include all of the information and footnotes required by GAAP for complete financial statements. In management’s opinion, the accompanying condensed consolidated financial statements reflect all adjustments, consisting of normal recurring adjustments, considered necessary for a fair presentation of the results for the interim periods presented. Interim financial results are not necessarily indicative of results anticipated for the full year. These condensed consolidated financial statements should be read in conjunction with the audited financial statements and footnotes included in the Company’s Annual Report on Form 10-K for the year ended December 31, 2019. These condensed consolidated financial statements are prepared in accordance with GAAP, which requires management to make estimates and assumptions regarding the valuation of certain debt and equity instruments, the disclosure of contingent assets and liabilities at the date of the financial statements and |
Liquidity | Liquidity The Company’s activities since inception have consisted principally of performing research and development activities, general and administration activities, and raising capital. The Company’s activities are subject to significant risks and uncertainties, including failing to secure additional funding before the Company achieves sustainable revenues and profit from operations. The Company is a clinical-stage bioscience company that is dependent on obtaining external equity and debt financings to fund its operations. Historically, the Company’s primary sources of financing have been through the sale of its securities, through issuance of debt and through collaboration agreements. As mentioned above, the Company was recently awarded a grant from the Singapore Economic Development Board of up to approximately $10.0 million to support the co-development of a potential COVID-19 vaccine with the Duke-NUS Medical School, approximately $5.0 million of which was awarded during the quarter ended March 31, 2020 and subsequently received in April 2020. Additionally, in April 2020 the Company completed an underwritten public offering of 4,735,297 shares of common stock (including the underwriters’ overallotment option) at a price of $17.00 per share. The Company received net proceeds of approximately $75.5 million in the offering. In May 2020, Ultragenyx exercised its option to purchase 600,000 shares of the Company’s common stock at $16 per share. The Company received proceeds of $9.6 million as a result of the option exercise. In July 2020 the Company completed an additional underwritten public offering of 4,243,395 shares of common stock (including the underwriters’ overallotment option) at a price of $53.00 per share. The Company received net proceeds of approximately $186.3 million in the offering. |
Segment Information | Segment Information Operating segments are identified as components of an enterprise about which separate discrete financial information is available for evaluation by the chief operating decision-maker in making decisions regarding resource allocation and assessing performance. The Company and its chief operating decision-maker view the Company’s operations and manage its business in one operating segment, which is the research and development of medical applications for the Company’s nucleic acid-focused technology. |
Revenue Recognition | Revenue Recognition Effective January 1, 2019, the Company adopted Accounting Standards Update (“ASU”) 2014-09, Revenue from Contracts with Customers (Topic 606) (“Topic 606”), The terms of the Company’s collaborative research and development agreements include license fees, upfront payments, milestone payments, and reimbursement for research and development activities, option exercise fees, and royalties on sales of commercialized products. Arrangements that include upfront payments are recorded as deferred revenue upon receipt or when due and may require deferral of revenue recognition to a future period until the Company performs obligations under these arrangements. The event-based milestone payments represent variable consideration, and the Company uses the most likely amount method to estimate this variable consideration because the Company will either receive the milestone payment or will not, which makes the potential milestone payment a binary event. The most likely amount method requires the Company to determine the likelihood of earning the milestone payment. Given the high degree of uncertainty around achievement of these milestones, the Company determines the milestone amounts to be fully constrained and does not recognize revenue until the uncertainty associated with these payments is resolved. The Company will recognize revenue from sales-based royalty payments when or as the sales occur. The Company will re-evaluate the transaction price in each reporting period as uncertain events are resolved and other changes in circumstances occur. A performance obligation is a promise in a contract to transfer a distinct good or service to the collaborative partner and is the unit of account in Topic 606. A contract’s transaction price is allocated to each distinct performance obligation based on relative standalone selling price and recognized as revenue when, or as, the performance obligation is satisfied. See “Note 2, Collaboration Revenue” |
Leases | Leases In February 2016, the FASB issued ASU 2016-02, Leases (Topic 842), which requires lessees to recognize most leases on the balance sheet as lease liabilities with corresponding right-of-use assets and to disclose key information about leasing arrangements. The Company adopted Topic 842 on its effective date in the first quarter of 2019 using a modified retrospective approach. The Company elected the available package of practical expedients upon adoption, which allowed it to carry forward historical assessments of whether existing agreements contained a lease and the classification of existing operating leases. See “Note 8, Commitments and Contingences” |
Research and Development, Net | Research and Development, Net Research and development costs are expensed as incurred. These expenses result from the Company’s independent research and development efforts as well as efforts associated with collaboration arrangements. Research and development costs include salaries and personnel-related costs, consulting fees, fees paid for contract research and manufacturing services, the costs of laboratory supplies, equipment and facilities, preclinical studies and other external costs are shown net of any grants. |
Statement of Cash Flows | Statement of Cash Flows The following table provides a reconciliation of cash and cash equivalents and restricted cash reported within the condensed consolidated balance sheet to the total of the same such amounts shown in the condensed consolidated statement of cash flows: (in thousands) June 30, 2020 June 30, 2019 Cash and cash equivalents $ 136,111 $ 55,840 Non-current restricted cash 107 107 Total cash, cash equivalents and restricted cash shown in the statement of cash flows $ 136,218 $ 55,947 |
Net Loss per Share | Net Loss per Share Basic net loss per share is calculated by dividing the net loss by the weighted-average number of shares of common stock outstanding for the period, without consideration for common stock equivalents. Diluted net loss per share is calculated by dividing the net loss by the weighted-average number of shares of common stock and dilutive common stock equivalents outstanding for the period determined using the treas ury-stock method. Dilutive shares of common stock are comprised of stock options. No dividends were declared or paid during the reported periods. |
Description of Business, Basi_3
Description of Business, Basis of Presentation and Summary of Significant Accounting Policies (Tables) | 6 Months Ended |
Jun. 30, 2020 | |
Accounting Policies [Abstract] | |
Schedule of Cash and Cash Equivalents and Restricted Cash | The following table provides a reconciliation of cash and cash equivalents and restricted cash reported within the condensed consolidated balance sheet to the total of the same such amounts shown in the condensed consolidated statement of cash flows: (in thousands) June 30, 2020 June 30, 2019 Cash and cash equivalents $ 136,111 $ 55,840 Non-current restricted cash 107 107 Total cash, cash equivalents and restricted cash shown in the statement of cash flows $ 136,218 $ 55,947 |
Collaboration Revenue (Tables)
Collaboration Revenue (Tables) | 6 Months Ended |
Jun. 30, 2020 | |
Collaboration Agreements [Abstract] | |
Summary of Changes in Balances of Contract Assets and Contract Liability | The following table presents changes during the six months ended June 30, 2020 in the balances of contract assets, including receivables from collaborative partners, and contract liabilities, including deferred revenue, as compared to what was disclosed in the Company’s 2019 Annual Report. (in thousands) Contract Assets BALANCE - December 31, 2019 $ 2,179 Additions for revenue recognized from billings 2,171 Deductions for cash collections (1,521 ) BALANCE – June 30, 2020 $ 2,829 (in thousands) Contract Liabilities BALANCE - December 31, 2019 $ 23,579 Additions for advanced billings 2,171 Deductions for promised services provided in current period (4,969 ) BALANCE – June 30, 2020 $ 20,781 |
Summary of Collaboration Revenue | The following table summarizes the Company’s collaboration revenues for the periods indicated (in thousands). For the Three Months Ended June 30, For the Six Months Ended June 30, (Dollars in thousands) 2020 2019 2020 2019 Collaboration Partner – Janssen $ 693 $ 622 $ 1,590 $ 1,135 Collaboration Partner – Ultragenyx 913 2,544 1,824 3,932 Collaboration Partner – CureVac 231 3,409 540 5,303 Collaboration Partner – Other 485 3,578 1,014 4,133 Total collaboration revenue $ 2,322 $ 10,153 $ 4,968 $ 14,503 |
Balance Sheet Details (Tables)
Balance Sheet Details (Tables) | 6 Months Ended |
Jun. 30, 2020 | |
Balance Sheet Related Disclosures [Abstract] | |
Summary of Components of Property and Equipment, Net | Property and equipment, net consisted of the following: (in thousands) June 30, 2020 December 31, 2019 Research equipment $ 4,282 $ 3,658 Computers and software 285 271 Office equipment and furniture 574 561 Leasehold improvements 44 40 Total 5,185 4,530 Less accumulated depreciation and amortization (2,575 ) (2,181 ) Property and equipment, net $ 2,610 $ 2,349 |
Schedule of Accrued Liabilities | Accrued liabilities consisted of the following as of June 30, 2020 and December 31, 2019: (in thousands) June 30, 2020 December 31, 2019 Accrued compensation $ 2,234 $ 1,608 Cystic Fibrosis Foundation Liability 3,010 1,949 Singapore Economic Development Board Liability 672 — Current portion of operating lease liability 1,337 827 Clinical Accruals 299 — Other accrued research and development expenses 4,331 2,750 Total $ 11,883 $ 7,134 |
Share-Based Compensation (Table
Share-Based Compensation (Tables) | 6 Months Ended |
Jun. 30, 2020 | |
Disclosure Of Compensation Related Costs Sharebased Payments [Abstract] | |
Schedule of Share-based Compensation Expenses | Share-based compensation expenses included in the Company’s condensed statements of operations and comprehensive loss for the three and six months ended June 30, 2020 and 2019 were: For the Three Months Ended June 30, For the Six Months Ended June 30, (in thousands) 2020 2019 2020 2019 Research and development $ 396 $ 157 $ 662 $ 308 General and administrative 705 246 1,288 494 Total $ 1,101 $ 403 $ 1,950 $ 802 |
Commitments and Contingencies (
Commitments and Contingencies (Tables) | 6 Months Ended |
Jun. 30, 2020 | |
Commitments And Contingencies Disclosure [Abstract] | |
Payments of Operating Lease Liability | As of June 30, 2020, the payments of the operating lease liability were as follows: (in thousands) Remaining Lease Payments 2020 (remaining) $ 992 2021 1,427 2022 1,349 2023 1,390 2024 1,432 Thereafter 314 Total remaining lease payments 6,904 Less: imputed interest (1,173 ) Total operating lease liabilities $ 5,731 Weighted-average remaining lease term 4.5 years Weighted-average discount rate 8.4 % |
Description of Business, Basi_4
Description of Business, Basis of Presentation and Summary of Significant Accounting Policies (Details Textual) $ / shares in Units, $ in Millions | 1 Months Ended | 6 Months Ended | |||||||
Jul. 31, 2020USD ($)$ / sharesshares | May 31, 2020USD ($)$ / sharesshares | Apr. 30, 2020USD ($)shares | Jun. 30, 2020USD ($)Segmentshares | Jun. 30, 2019USD ($) | Apr. 20, 2020$ / shares | Mar. 04, 2020USD ($) | Mar. 04, 2020SGD ($) | Dec. 31, 2019shares | |
Summary Of Significant Accounting Policy [Line Items] | |||||||||
Grant received | $ 5,000,000 | ||||||||
Proceeds from issuance of common stock, net of issuance costs | $ 75,305,000 | ||||||||
Common stock, shares issued | shares | 20,610,000 | 15,138,000 | |||||||
Number of operating segment for research and development | Segment | 1 | ||||||||
Dividends declared or paid | $ 0 | $ 0 | |||||||
ASU 2014-09 [Member] | |||||||||
Summary Of Significant Accounting Policy [Line Items] | |||||||||
Change in accounting principle, accounting standards update, adopted | true | ||||||||
Change in accounting principle, accounting standards update, adoption date | Jan. 1, 2019 | ||||||||
ASU 2016-02 [Member] | |||||||||
Summary Of Significant Accounting Policy [Line Items] | |||||||||
Change in accounting principle, accounting standards update, adopted | true | ||||||||
Change in accounting principle, accounting standards update, adoption date | Mar. 31, 2019 | ||||||||
Ultragenyx [Member] | |||||||||
Summary Of Significant Accounting Policy [Line Items] | |||||||||
Common stock, price per share | $ / shares | $ 16 | ||||||||
Common stock, shares issued | shares | 600,000 | ||||||||
Proceeds from issuance of common stock on option exercise | $ 9,600,000 | $ 9,600,000 | $ 15,545,000 | ||||||
Underwritten Public Offering [Member] | |||||||||
Summary Of Significant Accounting Policy [Line Items] | |||||||||
Issuance of common stock, net of issuance costs (in shares) | shares | 4,735,297 | ||||||||
Common stock, price per share | $ / shares | $ 17 | ||||||||
Underwritten Public Offering [Member] | Subsequent Event [Member] | |||||||||
Summary Of Significant Accounting Policy [Line Items] | |||||||||
Issuance of common stock, net of issuance costs (in shares) | shares | 4,243,395 | ||||||||
Common stock, price per share | $ / shares | $ 53 | ||||||||
Proceeds from issuance of common stock, net of issuance costs | $ 186,300,000 | ||||||||
Minimum [Member] | Underwritten Public Offering [Member] | |||||||||
Summary Of Significant Accounting Policy [Line Items] | |||||||||
Proceeds from issuance of common stock, net of issuance costs | $ 75,500,000 | ||||||||
Singapore Economic Development Board [Member] | Maximum [Member] | |||||||||
Summary Of Significant Accounting Policy [Line Items] | |||||||||
Grant awarded | $ 10,000,000 | $ 14 |
Schedule of Cash and Cash Equiv
Schedule of Cash and Cash Equivalents and Restricted Cash (Details) - USD ($) $ in Thousands | Jun. 30, 2020 | Dec. 31, 2019 | Jun. 30, 2019 | Dec. 31, 2018 |
Accounting Policies [Abstract] | ||||
Cash and cash equivalents | $ 136,111 | $ 71,353 | $ 55,840 | |
Non-current restricted cash | 107 | 107 | 107 | |
Total cash, cash equivalents and restricted cash shown in the statement of cash flows | $ 136,218 | $ 71,460 | $ 55,947 | $ 36,816 |
Collaboration Revenue - Summary
Collaboration Revenue - Summary of Changes in Balances of Contract Assets and Contract Liability (Details) $ in Thousands | 6 Months Ended |
Jun. 30, 2020USD ($) | |
Collaboration Agreements [Abstract] | |
Contract Assets, Balance | $ 2,179 |
Contract Assets, Additions for revenue recognized from billings | 2,171 |
Contract Assets, Deductions for cash collections | (1,521) |
Contract Assets, Balance | 2,829 |
Contract Liabilities, Balance | 23,579 |
Contract Liabilities, Additions for advanced billings | 2,171 |
Contract Liabilities, Deductions for promised services provided in current period | (4,969) |
Contract Liabilities, Balance | $ 20,781 |
Collaboration Revenue - Summa_2
Collaboration Revenue - Summary of Collaboration Revenues (Details) - USD ($) $ in Thousands | 3 Months Ended | 6 Months Ended | ||
Jun. 30, 2020 | Jun. 30, 2019 | Jun. 30, 2020 | Jun. 30, 2019 | |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] | ||||
Total collaboration revenue | $ 2,322 | $ 10,153 | $ 4,968 | $ 14,503 |
Collaboration Partner - Janssen [Member] | ||||
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] | ||||
Total collaboration revenue | 693 | 622 | 1,590 | 1,135 |
Collaboration Partner - Ultragenyx [Member] | ||||
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] | ||||
Total collaboration revenue | 913 | 2,544 | 1,824 | 3,932 |
Collaboration Partner - CureVac [Member] | ||||
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] | ||||
Total collaboration revenue | 231 | 3,409 | 540 | 5,303 |
Collaboration Partner – Other [Member] | ||||
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] | ||||
Total collaboration revenue | $ 485 | $ 3,578 | $ 1,014 | $ 4,133 |
Collaboration Revenue (Details
Collaboration Revenue (Details Textual) | Jul. 26, 2019USD ($) | Jun. 18, 2019USD ($)Target$ / sharesshares | Jun. 17, 2019$ / sharesshares | Feb. 11, 2019 | Oct. 31, 2017USD ($) | Jun. 30, 2020USD ($)shares | Jun. 30, 2020USD ($)shares | Dec. 31, 2019USD ($)shares | Jun. 16, 2019Target |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] | |||||||||
Deferred revenue | $ 20,781,000 | $ 20,781,000 | $ 23,579,000 | ||||||
Purchase of common stock, shares | shares | 20,610,000 | 20,610,000 | 15,138,000 | ||||||
Research Collaboration And Exclusive License Agreement [Member] | Collaboration Partner Janssen [Member] | |||||||||
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] | |||||||||
Upfront payment received | $ 7,700,000 | ||||||||
Revenue recognition potential milestone revenue recognized | $ 56,500,000 | ||||||||
Research Collaboration And Exclusive License Agreement [Member] | Collaboration Partner Janssen [Member] | ASC 606 [Member] | |||||||||
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] | |||||||||
Remaining performance obligation | $ 0 | $ 0 | |||||||
Deferred revenue | $ 6,000,000 | 6,000,000 | $ 5,900,000 | ||||||
Research Collaboration And Exclusive License Agreement [Member] | Collaboration Partner - Ultragenyx [Member] | |||||||||
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] | |||||||||
Upfront payment received | $ 6,000,000 | 27,900,000 | |||||||
Revenue recognition potential milestone revenue recognized | $ 138,000,000 | ||||||||
Royalty payment term description | Ultragenyx will pay royalties as a single-digit percentage of net sales on a product-by-product and country-by-country basis during the applicable royalty term. | ||||||||
Number of targets | Target | 12 | 10 | |||||||
Purchase of common stock, shares | shares | 2,400,000 | 600,000 | 600,000 | ||||||
Purchase of additional shares of common stock | shares | 600,000 | 600,000 | |||||||
Purchase of additional shares of common stock price per share | $ / shares | $ 16 | $ 16 | |||||||
Consideration received | $ 30,000,000 | ||||||||
Consideration received for common stock purchase | 24,000,000 | ||||||||
Transaction price | $ 14,400,000 | ||||||||
Collaboration agreement transfer restrictions termination date. | Nov. 20, 2020 | ||||||||
Research Collaboration And Exclusive License Agreement [Member] | Collaboration Partner - Ultragenyx [Member] | ASC 606 [Member] | |||||||||
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] | |||||||||
Remaining performance obligation | $ 0 | $ 0 | |||||||
Deferred revenue | 10,900,000 | $ 10,900,000 | 12,700,000 | ||||||
Revenue, practical expedient description | The Company recognizes the reimbursement of labor and expenses as costs are incurred and none of the development and commercialization milestones were included in the transaction price, as all milestone amounts were fully constrained. | ||||||||
Cumulative catch up adjustment | $ 1,100,000 | ||||||||
Revenue recognition, reserve target exclusivity period | 4 years | ||||||||
mRNA Technology [Member] | Collaboration Partner - CureVac [Member] | |||||||||
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] | |||||||||
Royalty payment term description | CureVac will pay royalties as a percentage of net sales on a product-by-product and country-by-country basis during the applicable royalty term in the low single-digit range | ||||||||
Development and option agreement date | Jan. 31, 2018 | ||||||||
Expiration of initial term | 8 years | ||||||||
Option to extend initial term on an annual basis | 3 years | ||||||||
mRNA Technology [Member] | Collaboration Partner - CureVac [Member] | Rare Disease Targets [Member] | |||||||||
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] | |||||||||
Revenue recognition potential milestone revenue recognized | $ 14,000,000 | ||||||||
mRNA Technology [Member] | Collaboration Partner - CureVac [Member] | Non-Rare Disease Targets [Member] | |||||||||
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] | |||||||||
Revenue recognition potential milestone revenue recognized | 23,000,000 | ||||||||
mRNA Technology [Member] | Collaboration Partner - CureVac [Member] | ASC 606 [Member] | |||||||||
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] | |||||||||
Remaining performance obligation | 0 | 0 | |||||||
Deferred revenue | 2,800,000 | $ 2,800,000 | $ 3,200,000 | ||||||
Revenue, practical expedient description | The Company recognizes the reimbursement of labor and expenses as costs are incurred and none of the development and commercialization milestones were included in the transaction price, as all milestone amounts were fully constrained. | ||||||||
Adjustments to transaction price | $ 0 | ||||||||
Upfront fee received | $ 5,000,000 | ||||||||
Contractual term | 37 months | ||||||||
Cumulative catch up adjustment | $ 400,000 | ||||||||
mRNA Technology [Member] | Collaboration Partner CureVac Entered Into Co Development Agreement [Member] | |||||||||
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] | |||||||||
Collaboration agreement termination date | Feb. 11, 2019 | ||||||||
Percentage of global rights reassumed | 100.00% | ||||||||
Termination Agreement [Member] | Collaboration Partner CureVac Entered Into Co Development Agreement [Member] | |||||||||
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] | |||||||||
Collaboration agreement settlement obligation one-time settled amount | $ 4,000,000 | ||||||||
Other Collaboration Agreements [Member] | Takeda Pharmaceutical Company Limited [Member] | |||||||||
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] | |||||||||
Revenue related to amortization of upfront payment | 500,000 | ||||||||
Other Collaboration Agreements [Member] | Synthetic Genomics Inc. [Member] | |||||||||
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] | |||||||||
Sublicense revenue recognized | $ 300,000 | ||||||||
Minimum [Member] | Collaboration Partner CureVac Entered Into Co Development Agreement [Member] | |||||||||
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] | |||||||||
Potential target license term | 4 years | ||||||||
Minimum [Member] | Research Collaboration And Exclusive License Agreement [Member] | Collaboration Partner Janssen [Member] | |||||||||
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] | |||||||||
Option exercise revenue range per target | 1,000,000 | ||||||||
Minimum [Member] | Research Collaboration And Exclusive License Agreement [Member] | Collaboration Partner - Ultragenyx [Member] | |||||||||
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] | |||||||||
Option exercise revenue range per target | 500,000 | ||||||||
Maximum [Member] | Collaboration Partner CureVac Entered Into Co Development Agreement [Member] | |||||||||
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] | |||||||||
Potential target license term | 8 years | ||||||||
Maximum [Member] | Research Collaboration And Exclusive License Agreement [Member] | Collaboration Partner Janssen [Member] | |||||||||
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] | |||||||||
Option exercise revenue range per target | 5,000,000 | ||||||||
Maximum [Member] | Research Collaboration And Exclusive License Agreement [Member] | Collaboration Partner - Ultragenyx [Member] | |||||||||
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] | |||||||||
Option exercise revenue range per target | $ 1,500,000 | ||||||||
Lack of marketability discount restricted period | 2 years |
Collaboration Revenue (Detail_2
Collaboration Revenue (Details Textual 1) | Jun. 30, 2020 |
Research Collaboration And Exclusive License Agreement [Member] | Collaboration Partner Janssen [Member] | ASC 606 [Member] | Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction, Start Date: 2020-07-01 | |
Revenue Remaining Performance Obligation Expected Timing Of Satisfaction [Line Items] | |
Remaining research period | 27 months |
Balance Sheet Details - Summary
Balance Sheet Details - Summary of Components of Property and Equipment, Net (Details) - USD ($) $ in Thousands | Jun. 30, 2020 | Dec. 31, 2019 |
Property Plant And Equipment [Line Items] | ||
Property and equipment, gross | $ 5,185 | $ 4,530 |
Less accumulated depreciation and amortization | (2,575) | (2,181) |
Property and equipment, net | 2,610 | 2,349 |
Research equipment [Member] | ||
Property Plant And Equipment [Line Items] | ||
Property and equipment, gross | 4,282 | 3,658 |
Computer and software [Member] | ||
Property Plant And Equipment [Line Items] | ||
Property and equipment, gross | 285 | 271 |
Office equipment and furniture [Member] | ||
Property Plant And Equipment [Line Items] | ||
Property and equipment, gross | 574 | 561 |
Leasehold improvements [Member] | ||
Property Plant And Equipment [Line Items] | ||
Property and equipment, gross | $ 44 | $ 40 |
Balance Sheet Details (Details
Balance Sheet Details (Details Textual) - USD ($) $ in Thousands | 3 Months Ended | 6 Months Ended | ||
Jun. 30, 2020 | Jun. 30, 2019 | Jun. 30, 2020 | Jun. 30, 2019 | |
Balance Sheet Related Disclosures [Abstract] | ||||
Depreciation and amortization | $ 200 | $ 200 | $ 394 | $ 349 |
Balance Sheet Details - Schedul
Balance Sheet Details - Schedule of Accrued Liabilities (Details) - USD ($) $ in Thousands | Jun. 30, 2020 | Dec. 31, 2019 |
Accrued Liabilities Current [Abstract] | ||
Accrued compensation | $ 2,234 | $ 1,608 |
Cystic Fibrosis Foundation Liability | 3,010 | 1,949 |
Singapore Economic Development Board Liability | 672 | |
Current portion of operating lease liability | 1,337 | 827 |
Clinical Accruals | 299 | |
Other accrued research and development expenses | 4,331 | 2,750 |
Total | $ 11,883 | $ 7,134 |
Debt (Details Textual)
Debt (Details Textual) - USD ($) | Oct. 30, 2019 | Oct. 12, 2018 | Jun. 30, 2020 | Jun. 30, 2019 | Jun. 30, 2020 | Jun. 30, 2019 |
Debt Instrument [Line Items] | ||||||
Repayment of long-term debt for remainder of fiscal year | $ 0 | $ 0 | ||||
Repayment of long-term debt for year, 2021 | 1,300,000 | 1,300,000 | ||||
Repayment of long-term debt for year, 2022 | 7,500,000 | 7,500,000 | ||||
Repayment of long-term debt for year, 2023 | 6,700,000 | 6,700,000 | ||||
Interest expense related to long-term debt | $ 200,000 | $ 200,000 | $ 500,000 | $ 400,000 | ||
Loan and Security Agreement [Member] | Western Alliance Bank [Member] | Long-term Debt [Member] | ||||||
Debt Instrument [Line Items] | ||||||
Proceeds from long-term debt agreement | $ 10,000,000 | |||||
Debt instrument, collateral | The Loan is collateralized by all of the assets of the Company, excluding intellectual property, which is subject to a negative pledge. The Loan contains customary conditions of borrowing, events of default and covenants, including covenants that restrict the Company’s ability to dispose of assets, merge with or acquire other entities, incur indebtedness and make distributions to holders of the Company’s capital stock. In addition, the Company is required to maintain at least 100% of its consolidated, unrestricted cash, or $15.0 million, whichever is lower, with the Bank. | |||||
Debt instrument, collateral amount | $ 15,000,000 | |||||
Term loan | $ 15,000,000 | |||||
Net increase in indebtedness | $ 5,000,000 | |||||
Loan maturity date | Oct. 30, 2023 | |||||
Loan interest-only payment extended maturity date | Oct. 1, 2021 | |||||
Loan origination fee paid | 54,000 | |||||
Warrant fee payable | $ 525,000 | |||||
Prepayment fee percentage | 2.00% | |||||
Loan and Security Agreement [Member] | Western Alliance Bank [Member] | Long-term Debt [Member] | Minimum [Member] | ||||||
Debt Instrument [Line Items] | ||||||
Percentage required to be maintain in consolidated, unrestricted cash | 100.00% | |||||
Interest of the prime rate plus | 1.25% | |||||
Prepayment fee percentage | 0.50% | |||||
Loan and Security Agreement [Member] | Western Alliance Bank [Member] | Long-term Debt [Member] | Maximum [Member] | ||||||
Debt Instrument [Line Items] | ||||||
Interest of the prime rate plus | 2.75% | |||||
Prepayment fee percentage | 2.00% |
Stockholders' Equity (Details T
Stockholders' Equity (Details Textual) | 1 Months Ended | 3 Months Ended | 6 Months Ended | 12 Months Ended | ||||
Mar. 31, 2013$ / sharesshares | Jun. 30, 2020shares | Jun. 30, 2019shares | Jun. 30, 2020shares | Jun. 30, 2019shares | Dec. 31, 2017USD ($)Milestoneshares | Dec. 31, 2016Milestone | Dec. 31, 2014shares | |
Class Of Stock [Line Items] | ||||||||
Antidilutive securities excluded from computation of earnings per share | 1,505,244 | 93,407 | 903,949 | 80,585 | ||||
Unvested Restricted Ordinary Shares [Member] | ||||||||
Class Of Stock [Line Items] | ||||||||
Antidilutive securities excluded from computation of earnings per share | 311,333 | 311,333 | 311,333 | 311,333 | ||||
Restricted Common Shares [Member] | ||||||||
Class Of Stock [Line Items] | ||||||||
Stock issued during period | 2,783,686 | |||||||
Share price of stock issued | $ / shares | $ 0.0068 | |||||||
Shares subject to repurchase option | 1,538,353 | |||||||
Share based compensation arrangement by share based payment award period from termination date of employee or consultant for repurchase of shares | 2 months | |||||||
Number of milestones achieved | Milestone | 2 | 2 | ||||||
Common shares, unvested | 311,333 | 622,667 | 311,333 | 622,667 | 769,176 | |||
Accelerated ordinary shares vested | 146,510 | |||||||
Modification expense resulting from accelerated vesting of ordinary shares | $ | $ 1,495,000 | |||||||
Vested After Obtaining Suitable siRNA License [Member] | Restricted Common Shares [Member] | ||||||||
Class Of Stock [Line Items] | ||||||||
Shares vesting percentage | 25.00% | |||||||
Vested After in Vivo Proof-of-concept Achieved [Member] | Restricted Common Shares [Member] | ||||||||
Class Of Stock [Line Items] | ||||||||
Shares vesting percentage | 25.00% | |||||||
Vested After IND Application Completed [Member] | Restricted Common Shares [Member] | ||||||||
Class Of Stock [Line Items] | ||||||||
Shares vesting percentage | 25.00% | |||||||
Vested After in Human Efficacy Achieved [Member] | Restricted Common Shares [Member] | ||||||||
Class Of Stock [Line Items] | ||||||||
Shares vesting percentage | 25.00% |
Share-Based Compensation (Detai
Share-Based Compensation (Details Textual) - shares | Jun. 30, 2020 | Jun. 30, 2019 |
2019 Omnibus Equity Incentive Plan [Member] | Stock Option | ||
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] | ||
Common stock reserved for future issuance | 2,616,340 | |
2019 Omnibus Equity Incentive Plan [Member] | Minimum [Member] | ||
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] | ||
Share-based compensation number of shares authorized | 3,150,000 | |
2019 Omnibus Equity Incentive Plan [Member] | Maximum [Member] | ||
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] | ||
Share-based compensation number of shares authorized | 5,750,000 | 2,600,000 |
2020 Employee Stock Purchase Plan [Member] | Stock Option | ||
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] | ||
Common stock reserved for future issuance | 600,000 |
Share-Based Compensation (Det_2
Share-Based Compensation (Details 2) - USD ($) $ in Thousands | 3 Months Ended | 6 Months Ended | ||
Jun. 30, 2020 | Jun. 30, 2019 | Jun. 30, 2020 | Jun. 30, 2019 | |
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] | ||||
Share-based compensation expenses | $ 1,101 | $ 403 | $ 1,950 | $ 802 |
Research and Development [Member] | ||||
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] | ||||
Share-based compensation expenses | 396 | 157 | 662 | 308 |
General and Administrative [Member] | ||||
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] | ||||
Share-based compensation expenses | $ 705 | $ 246 | $ 1,288 | $ 494 |
Income Taxes (Details Textual)
Income Taxes (Details Textual) - USD ($) $ in Millions | 3 Months Ended | 6 Months Ended |
Jun. 30, 2020 | Jun. 30, 2020 | |
Income Tax Disclosure [Abstract] | ||
Income tax expense | $ 0 | $ 0 |
Commitments and Contingencies_2
Commitments and Contingencies (Details Textual) $ in Millions | Jul. 13, 2019USD ($) | Jul. 12, 2019USD ($) | Feb. 29, 2020 | Oct. 31, 2017USD ($) | Jun. 30, 2020USD ($) | Jun. 30, 2019USD ($) | Jun. 30, 2020USD ($) | Jun. 30, 2019USD ($) | Mar. 04, 2020USD ($) | Mar. 04, 2020SGD ($) |
Commitment And Contingencies [Line Items] | ||||||||||
Operating lease extended additional term | 13 months | |||||||||
Operating lease, remaining lease term | 4 years 6 months | 4 years 6 months | ||||||||
Lessee, operating lease, term of contract | 1 month | |||||||||
Lessee, operating leases, option to extend | The lease may be extended for one twelve-month period; | |||||||||
Operating lease costs | $ 500,000 | $ 300,000 | $ 900,000 | $ 600,000 | ||||||
COVID-19 Vaccine Development | ||||||||||
Commitment And Contingencies [Line Items] | ||||||||||
Contra research and development expense recognized | 3,800,000 | 4,300,000 | ||||||||
Contra expense remaining amount included in accrued expenses | 700,000 | 700,000 | ||||||||
Underlying Agreement [Member] | Cystic Fibrosis Foundation [Member] | ||||||||||
Commitment And Contingencies [Line Items] | ||||||||||
Contra expense remaining amount included in accrued expenses | 3,000,000 | 3,000,000 | ||||||||
Payments for matching funds for remaining budgeted costs | $ 5,000,000 | |||||||||
Disbursed amount upon execution of amendment | 4,000,000 | |||||||||
Final payment of disbursement amount | 3,000,000 | |||||||||
Disbursement payment upon achievement of required manufacturing practices and IND application | 2,300,000 | |||||||||
Contra expense included in research and development expense | $ 900,000 | $ 2,900,000 | $ 0 | |||||||
Underlying Agreement [Member] | Cystic Fibrosis Foundation [Member] | Disbursement Due January 2020 [Member] | ||||||||||
Commitment And Contingencies [Line Items] | ||||||||||
Disbursement amount payable upon achievement of project goal | 2,000,000 | |||||||||
Underlying Agreement [Member] | Cystic Fibrosis Foundation [Member] | Disbursement Due April 2020 [Member] | ||||||||||
Commitment And Contingencies [Line Items] | ||||||||||
Disbursement amount payable upon achievement of project goal | 2,000,000 | |||||||||
Underlying Agreement [Member] | Cystic Fibrosis Foundation [Member] | Disbursement Due July 2020 [Member] | ||||||||||
Commitment And Contingencies [Line Items] | ||||||||||
Disbursement amount payable upon achievement of project goal | 2,000,000 | |||||||||
Underlying Agreement [Member] | Cystic Fibrosis Foundation [Member] | Disbursement Due October 2020 [Member] | ||||||||||
Commitment And Contingencies [Line Items] | ||||||||||
Disbursement amount payable upon achievement of project goal | 2,000,000 | |||||||||
Underlying Agreement [Member] | LUNAR-CF [Member] | Cystic Fibrosis Foundation [Member] | ||||||||||
Commitment And Contingencies [Line Items] | ||||||||||
Payments for advance | $ 15,000,000 | $ 3,200,000 | ||||||||
October 2017 Lease Amendment [Member] | ||||||||||
Commitment And Contingencies [Line Items] | ||||||||||
Operating lease extended additional term | 84 months | |||||||||
Lessee, operating lease, term of contract | 4 months | |||||||||
Tenant improvement allowance | $ 74,000 | |||||||||
Lessee, operating leases, option to extend | The lease may be extended for one five-year period at the then current market rate with annual escalations; | |||||||||
Security deposit | $ 96,000 | |||||||||
Singapore Economic Development Board [Member] | Maximum [Member] | ||||||||||
Commitment And Contingencies [Line Items] | ||||||||||
Grant awarded | $ 10,000,000 | $ 14 | ||||||||
Singapore Economic Development Board [Member] | Maximum [Member] | COVID-19 Vaccine Development | ||||||||||
Commitment And Contingencies [Line Items] | ||||||||||
Grant awarded | $ 10,000,000 | $ 14 |
Commitments and Contingencies -
Commitments and Contingencies - Payments of Operating Lease Liability (Details) $ in Thousands | Jun. 30, 2020USD ($) |
Leases [Abstract] | |
2020 (remaining) | $ 992 |
2021 | 1,427 |
2022 | 1,349 |
2023 | 1,390 |
2024 | 1,432 |
Thereafter | 314 |
Total remaining lease payments | 6,904 |
Less: imputed interest | (1,173) |
Total operating lease liabilities | $ 5,731 |
Weighted-average remaining lease term | 4 years 6 months |
Weighted-average discount rate | 8.40% |
Related Party Transactions - Ul
Related Party Transactions - Ultragenyx (Details Textual) - USD ($) $ / shares in Units, $ in Thousands | Jun. 18, 2019 | Jun. 17, 2019 | Jun. 30, 2020 | Jun. 30, 2019 | Jun. 30, 2020 | Jun. 30, 2019 |
Related Party Transaction [Line Items] | ||||||
Collaboration revenue | $ 2,322 | $ 10,153 | $ 4,968 | $ 14,503 | ||
Collaboration Partner - Ultragenyx [Member] | ||||||
Related Party Transaction [Line Items] | ||||||
Collaboration revenue | 913 | 2,544 | $ 1,824 | 3,932 | ||
Research Collaboration And Exclusive License Agreement [Member] | Collaboration Partner - Ultragenyx [Member] | ||||||
Related Party Transaction [Line Items] | ||||||
Common stock shares restricted from selling period subsequent to issuance date | 2 years | |||||
Purchase of additional shares of common stock | 600,000 | 600,000 | ||||
Purchase of additional shares of common stock price per share | $ 16 | $ 16 | ||||
Ownership interest of common stock | 14.60% | |||||
Collaboration revenue | $ 900 | $ 2,500 | $ 1,800 | $ 3,900 |
Related Party Transactions - Eq
Related Party Transactions - Equity-Method Investment (Details Textual) - USD ($) $ in Thousands | 3 Months Ended | 6 Months Ended | ||
Jun. 30, 2020 | Jun. 30, 2020 | Jun. 30, 2019 | Jun. 30, 2018 | |
Related Party Transaction [Line Items] | ||||
Share of losses for investee | $ 100 | $ 263 | $ 288 | |
ADAIR Technology [Member] | ||||
Related Party Transaction [Line Items] | ||||
Equity method ownership percentage | 30.00% | |||
Share of losses for investee | $ 100 | $ 300 | ||
ADAIR Technology [Member] | Minimum [Member] | ||||
Related Party Transaction [Line Items] | ||||
Equity method ownership percentage | 19.00% | 19.00% |
Subsequent Events (Details Text
Subsequent Events (Details Textual) | Jul. 23, 2020 |
Subsequent Event [Member] | |
Subsequent Event [Line Items] | |
Number of days intend to finalize comprehensive supply agreement | 30 days |