Ikarian Capital 13F-HR/A Quarterly holdings report by institutional manager (amended)

The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

OMB APPROVAL

OMB Number:		3235-0006
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COLUMN 1	COLUMN 2	COLUMN 3	COLUMN 4	COLUMN 5			COLUMN 6	COLUMN 7	COLUMN 8
			VALUE	SHRS OR	SH/	PUT/	INVESTMENT	OTHER	VOTING AUTHORITY
NAME OF ISSUER	TITLE OF CLASS	CUSIP	(x$1000)	PRN AMT	PRN	CALL	DISCRETION	MANAGER	SOLE	SHARED	NONE
10X GENOMICS INC	CL A COM	88025U109	12,669	70,000	SH	Put	SOLE		70,000	0	0
AC IMMUNE SA	SHS	H00263105	911	119,803	SH		SOLE		119,803	0	0
ACADIA PHARMACEUTICALS INC	COM	004225108	14,921	578,300	SH	Put	SOLE		578,300	0	0
ACADIA PHARMACEUTICALS INC	COM	004225108	155	6,008	SH		SOLE		6,008	0	0
ACHIEVE LIFE SCIENCES INC	COM	004468500	3,291	284,151	SH		SOLE		284,151	0	0
ACLARIS THERAPEUTICS INC	COM	00461U105	4,742	188,200	SH		SOLE		188,200	0	0
ADC THERAPEUTICS SA	SHS	H0036K147	7,323	300,000	SH	Call	SOLE		300,000	0	0
ADICET BIO INC	COM	007002108	1,768	135,094	SH		SOLE		135,094	0	0
ADVISORSHARES TR	PURE US CANNABIS	00768Y453	6,360	150,000	SH	Call	SOLE		150,000	0	0
AERPIO PHARMACEUTICALS INC	COM	00810B105	3,420	2,651,093	SH		SOLE		2,651,093	0	0
AGENUS INC	COM NEW	00847G705	1,847	678,843	SH		SOLE		678,843	0	0
AGIOS PHARMACEUTICALS INC	COM	00847X104	6,456	125,000	SH	Call	SOLE		125,000	0	0
AILERON THERAPEUTICS INC	COM	00887A105	4,004	2,800,000	SH		SOLE		2,800,000	0	0
ALBIREO PHARMA INC	COM	01345P106	595	16,883	SH		SOLE		16,883	0	0
ALECTOR INC	COM	014442107	5,185	257,500	SH		SOLE		257,500	0	0
ALLAKOS INC	COM	01671P100	4,327	37,700	SH	Put	SOLE		37,700	0	0
ALLAKOS INC	COM	01671P100	4,935	43,000	SH	Call	SOLE		43,000	0	0
ALLAKOS INC	COM	01671P100	3,639	31,700	SH		SOLE		31,700	0	0
ALLOGENE THERAPEUTICS INC	COM	019770106	4,115	116,600	SH	Call	SOLE		116,600	0	0
ALLOVIR INC	COM	019818103	4,680	200,000	SH	Call	SOLE		200,000	0	0
ALPINE IMMUNE SCIENCES INC	COM	02083G100	3,230	304,739	SH		SOLE		304,739	0	0
ALTIMMUNE INC	COM NEW	02155H200	2,571	181,941	SH		SOLE		181,941	0	0
AMICUS THERAPEUTICS INC	COM	03152W109	3,373	341,500	SH		SOLE		341,500	0	0
ANAPTYSBIO INC	COM	032724106	207	9,553	SH		SOLE		9,553	0	0
ANAPTYSBIO INC	COM	032724106	3,925	182,100	SH	Call	SOLE		182,100	0	0
ANNOVIS BIO INC	COM	03615A108	5,395	193,368	SH		SOLE		193,368	0	0
APPLIED GENETIC TECHNOLOGIES	COM	03820J100	2,108	415,884	SH		SOLE		415,884	0	0
APTOSE BIOSCIENCES INC	COM NEW	03835T200	622	103,904	SH		SOLE		103,904	0	0
ARBUTUS BIOPHARMA CORP	COM	03879J100	383	115,000	SH		SOLE		115,000	0	0
ARCUS BIOSCIENCES INC	COM	03969F109	6,894	245,500	SH	Put	SOLE		245,500	0	0
ARDELYX INC	COM	039697107	6,821	1,030,436	SH		SOLE		1,030,436	0	0
ARENA PHARMACEUTICALS INC	COM NEW	040047607	10,408	150,000	SH	Call	SOLE		150,000	0	0
ARENA PHARMACEUTICALS INC	COM NEW	040047607	153	2,200	SH		SOLE		2,200	0	0
ARGENX SE	SPONSORED ADR	04016X101	7,407	26,900	SH	Call	SOLE		26,900	0	0
ARGENX SE	SPONSORED ADR	04016X101	9,500	34,500	SH	Put	SOLE		34,500	0	0
ARK ETF TR	GENOMIC REV ETF	00214Q302	178	2,000	SH		SOLE		2,000	0	0
ARK ETF TR	GENOMIC REV ETF	00214Q302	75,776	854,000	SH	Put	SOLE		854,000	0	0
ARK ETF TR	INNOVATION ETF	00214Q104	131,945	1,100,000	SH	Put	SOLE		1,100,000	0	0
ARVINAS INC	COM	04335A105	558	8,430	SH		SOLE		8,430	0	0
ASCENDIS PHARMA A/S	SPONSORED ADR	04351P101	8,001	62,090	SH		SOLE		62,090	0	0
ASCENDIS PHARMA A/S	SPONSORED ADR	04351P101	6,534	50,700	SH	Call	SOLE		50,700	0	0
ASLAN PHARMACEUTICALS LTD	ADS	04522R101	243	1,224,516	SH		SOLE		1,224,516	0	0
ASSEMBLY BIOSCIENCES INC	COM	045396108	334	72,468	SH		SOLE		72,468	0	0
ASTRAZENECA PLC	SPONSORED ADR	046353108	17,401	350,000	SH	Call	SOLE		350,000	0	0
ATYR PHARMA INC	COM NEW	002120202	1,336	300,000	SH		SOLE		300,000	0	0
AURINIA PHARMACEUTICALS INC	COM	05156V102	1,298	100,000	SH	Call	SOLE		100,000	0	0
AURIS MEDICAL HOLDING LTD	SHS	G07025201	1,605	461,522	SH		SOLE		461,522	0	0
AUTOLUS THERAPEUTICS PLC	SPON ADS	05280R100	7,196	1,256,048	SH		SOLE		1,256,048	0	0
BAUDAX BIO INC	COM	07160F107	129	100,000	SH		SOLE		100,000	0	0
BAUSCH HEALTH COS INC	COM	071734107	25,392	800,000	SH	Call	SOLE		800,000	0	0
BCLS ACQUISITION CORP	COM CL A	G0904B105	794	75,100	SH		SOLE		75,100	0	0
BCTG ACQUISITION CORP	COM	05492W103	3,340	300,250	SH		SOLE		300,250	0	0
BEAM THERAPEUTICS INC	COM	07373V105	28,813	360,000	SH	Put	SOLE		360,000	0	0
BEIGENE LTD	SPONSORED ADR	07725L102	55,867	160,500	SH	Put	SOLE		160,500	0	0
BEIGENE LTD	SPONSORED ADR	07725L102	3,655	10,500	SH	Call	SOLE		10,500	0	0
BELLICUM PHARMACEUTICALS INC	COM NEW	079481404	1,881	500,000	SH		SOLE		500,000	0	0
BELLUS HEALTH INC NEW	COM NEW	07987C204	1,537	400,000	SH		SOLE		400,000	0	0
BIOATLA INC	COM	09077B104	3,567	70,160	SH		SOLE		70,160	0	0
BIOGEN INC	COM	09062X103	1,594	5,700	SH		SOLE		5,700	0	0
BIOGEN INC	COM	09062X103	110,475	394,900	SH	Call	SOLE		394,900	0	0
BIOXCEL THERAPEUTICS INC	COM	09075P105	6,474	150,000	SH	Call	SOLE		150,000	0	0
BIOXCEL THERAPEUTICS INC	COM	09075P105	226	5,232	SH		SOLE		5,232	0	0
BLACK DIAMOND THERAPEUTICS I	COM	09203E105	3,735	153,941	SH		SOLE		153,941	0	0
BLUEBIRD BIO INC	COM	09609G100	3,203	106,200	SH	Call	SOLE		106,200	0	0
BLUEBIRD BIO INC	COM	09609G100	8	281	SH		SOLE		281	0	0
BLUEPRINT MEDICINES CORP	COM	09627Y109	11,667	120,000	SH	Put	SOLE		120,000	0	0
BOEING CO	COM	097023105	15,283	60,000	SH	Call	SOLE		60,000	0	0
BRAINSTORM CELL THERAPEUTICS	COM NEW	10501E201	1,122	293,200	SH		SOLE		293,200	0	0
C4 THERAPEUTICS INC	COM STK	12529R107	4,124	111,500	SH		SOLE		111,500	0	0
CABALETTA BIO INC	COM	12674W109	4,323	389,384	SH		SOLE		389,384	0	0
CARA THERAPEUTICS INC	COM	140755109	18,379	846,600	SH	Call	SOLE		846,600	0	0
CARA THERAPEUTICS INC	COM	140755109	12,125	558,524	SH		SOLE		558,524	0	0
CARDIFF ONCOLOGY INC	COM	14147L108	3,870	417,900	SH	Put	SOLE		417,900	0	0
CASI PHARMACEUTICALS INC	COM	14757U109	3,044	1,268,154	SH		SOLE		1,268,154	0	0
CATABASIS PHARMACEUTICALS IN	COM NEW	14875P206	2,464	852,998	SH		SOLE		852,998	0	0
CATALYST BIOSCIENCES INC	COM NEW	14888D208	2,929	581,200	SH		SOLE		581,200	0	0
CEL-SCI CORP	COM PAR NEW	150837607	1,627	106,900	SH	Call	SOLE		106,900	0	0
CELLDEX THERAPEUTICS INC NEW	COM NEW	15117B202	10,373	503,500	SH	Call	SOLE		503,500	0	0
CELLDEX THERAPEUTICS INC NEW	COM NEW	15117B202	12,284	596,290	SH		SOLE		596,290	0	0
CERECOR INC	COM	15671L109	2,710	897,330	SH		SOLE		897,330	0	0
CHARDAN HEALTHCR ACQSTN 2 CO	UNIT 99/99/9999	15957T206	4,399	400,000	SH		SOLE		400,000	0	0
CHARDAN HEALTHCR ACQSTN 2 CO	COM	15957T107	301	30,000	SH		SOLE		30,000	0	0
CHEMBIO DIAGNOSTICS INC	COM NEW	163572209	769	219,109	SH		SOLE		219,109	0	0
CHEMOCENTRYX INC	COM	16383L106	10,248	200,000	SH	Call	SOLE		200,000	0	0
CHEMOCENTRYX INC	COM	16383L106	26,235	512,000	SH	Put	SOLE		512,000	0	0
CHIASMA INC	COM	16706W102	1,909	610,299	SH		SOLE		610,299	0	0
CHIMERIX INC	COM	16934W106	1,446	150,000	SH	Call	SOLE		150,000	0	0
CHIMERIX INC	COM	16934W106	15,399	1,597,514	SH		SOLE		1,597,514	0	0
CLENE INC	COMMON STOCK	185634102	1,516	118,533	SH		SOLE		118,533	0	0
CLOVER HEALTH INVESTMENTS CO	COM CL A	18914F103	757	100,000	SH		SOLE		100,000	0	0
CLOVER HEALTH INVESTMENTS CO	COM CL A	18914F103	1,890	250,000	SH	Call	SOLE		250,000	0	0
CLOVIS ONCOLOGY INC	COM	189464100	4,771	679,473	SH		SOLE		679,473	0	0
COMPASS PATHWAYS PLC	SPONSORED ADS	20451W101	8,318	225,926	SH		SOLE		225,926	0	0
COMPUGEN LTD	ORD	M25722105	4	500	SH	Put	SOLE		500	0	0
CORBUS PHARMACEUTICALS HLDGS	COM	21833P103	1,899	964,100	SH		SOLE		964,100	0	0
CORVUS PHARMACEUTICALS INC	COM	221015100	307	100,000	SH		SOLE		100,000	0	0
CRISPR THERAPEUTICS AG	NAMEN AKT	H17182108	5,105	41,900	SH	Put	SOLE		41,900	0	0
CRISPR THERAPEUTICS AG	NAMEN AKT	H17182108	1,838	15,084	SH		SOLE		15,084	0	0
CRYOPORT INC	COM PAR $0.001	229050307	151	2,900	SH		SOLE		2,900	0	0
CULLINAN ONCOLOGY INC	COM	230031106	42	1,000	SH		SOLE		1,000	0	0
CUREVAC N V	COM	N2451R105	32,925	360,000	SH	Put	SOLE		360,000	0	0
CUREVAC N V	COM	N2451R105	9,145	100,000	SH	Call	SOLE		100,000	0	0
CURIS INC	COM NEW	231269200	1,132	100,000	SH	Call	SOLE		100,000	0	0
CURIS INC	COM NEW	231269200	13,815	1,220,356	SH		SOLE		1,220,356	0	0
CYCLACEL PHARMACEUTICALS INC	COM	23254L603	2,133	300,000	SH		SOLE		300,000	0	0
CYCLERION THERAPEUTICS INC	COM	23255M105	836	300,000	SH		SOLE		300,000	0	0
CYTOKINETICS INC	COM NEW	23282W605	2,954	127,000	SH		SOLE		127,000	0	0
DBV TECHNOLOGIES S A	SPONSORED ADR	23306J101	3,387	322,730	SH		SOLE		322,730	0	0
DELCATH SYS INC	COM NEW	24661P807	546	43,915	SH		SOLE		43,915	0	0
DIAMEDICA THERAPEUTICS INC	COM NEW	25253X207	3,797	415,000	SH		SOLE		415,000	0	0
ELEDON PHARMACEUTICALS INC	COM	28617K101	2,676	250,000	SH		SOLE		250,000	0	0
ESSA PHARMA INC	COM NEW	29668H708	7,694	264,868	SH		SOLE		264,868	0	0
EXACT SCIENCES CORP	COM	30063P105	27,015	205,000	SH	Put	SOLE		205,000	0	0
EYEPOINT PHARMACEUTICALS INC	COM NEW	30233G209	2,116	208,500	SH	Call	SOLE		208,500	0	0
EYEPOINT PHARMACEUTICALS INC	COM NEW	30233G209	1,221	120,135	SH		SOLE		120,135	0	0
FATE THERAPEUTICS INC	COM	31189P102	8,978	108,900	SH	Put	SOLE		108,900	0	0
FATE THERAPEUTICS INC	COM	31189P102	297	3,600	SH		SOLE		3,600	0	0
FIBROGEN INC	COM	31572Q808	10,412	300,000	SH	Put	SOLE		300,000	0	0
FINCH THERAPEUTICS GROUP INC	COM	31773D101	2,387	150,000	SH		SOLE		150,000	0	0
FRAZIER LIFESCIENCES ACQU CO	UNIT 12/09/2025	G3710A121	766	75,000	SH		SOLE		75,000	0	0
FREQUENCY THERAPEUTICS INC	COM	35803L108	958	100,800	SH	Put	SOLE		100,800	0	0
FREQUENCY THERAPEUTICS INC	COM	35803L108	1,900	200,000	SH	Call	SOLE		200,000	0	0
FREQUENCY THERAPEUTICS INC	COM	35803L108	536	56,479	SH		SOLE		56,479	0	0
FULCRUM THERAPEUTICS INC	COM	359616109	5,026	426,739	SH		SOLE		426,739	0	0
GALAPAGOS NV	SPON ADR	36315X101	7,709	100,000	SH	Call	SOLE		100,000	0	0
GALAPAGOS NV	SPON ADR	36315X101	15,513	200,000	SH		SOLE		200,000	0	0
GAMIDA CELL LTD	SHS	M47364100	1,102	136,142	SH		SOLE		136,142	0	0
GEMINI THERAPEUTICS INC	COM	36870G105	9,273	684,379	SH		SOLE		684,379	0	0
GENOCEA BIOSCIENCES INC	COM NEW	372427401	213	78,767	SH		SOLE		78,767	0	0
GILEAD SCIENCES INC	COM	375558103	28,668	443,600	SH	Call	SOLE		443,600	0	0
GOSSAMER BIO INC	COM	38341P102	2,775	300,000	SH	Call	SOLE		300,000	0	0
GOSSAMER BIO INC	COM	38341P102	9,697	1,048,383	SH		SOLE		1,048,383	0	0
GW PHARMACEUTICALS PLC	ADS	36197T103	25,833	119,100	SH	Put	SOLE		119,100	0	0
HARPOON THERAPEUTICS INC	COM	41358P106	5,619	268,600	SH		SOLE		268,600	0	0
HEALTH SCIENCES ACQ CORP 2	ORD SHS	G4411D109	2,246	200,000	SH		SOLE		200,000	0	0
HIGHCAPE CAP ACQUISITION COR	COM CL A	42984L105	3,099	260,000	SH		SOLE		260,000	0	0
HORIZON THERAPEUTICS PUB L	SHS	G46188101	58,186	632,200	SH	Call	SOLE		632,200	0	0
HORIZON THERAPEUTICS PUB L	SHS	G46188101	56	603	SH		SOLE		603	0	0
I MAB	SPONSORED ADS	44975P103	12,117	250,000	SH		SOLE		250,000	0	0
ICAD INC	COM NEW	44934S206	4,618	217,637	SH		SOLE		217,637	0	0
IGM BIOSCIENCES INC	COM	449585108	19,172	250,000	SH	Put	SOLE		250,000	0	0
IGM BIOSCIENCES INC	COM	449585108	23	300	SH		SOLE		300	0	0
IMMATICS N.V	SHS	N44445109	2,860	255,138	SH		SOLE		255,138	0	0
IMMUNOPRECISE ANTIBODIES LTD	COM NEW	45257F200	1,472	150,000	SH		SOLE		150,000	0	0
IMMUNOVANT INC	COM	45258J102	5,802	361,700	SH	Call	SOLE		361,700	0	0
IMMUNOVANT INC	COM	45258J102	3,895	242,800	SH	Put	SOLE		242,800	0	0
INCYTE CORP	COM	45337C102	1,870	23,012	SH		SOLE		23,012	0	0
INCYTE CORP	COM	45337C102	16,254	200,000	SH	Call	SOLE		200,000	0	0
INFLARX NV	COM	N44821101	2,729	699,750	SH		SOLE		699,750	0	0
INHIBRX INC	COM	45720L107	161	8,076	SH		SOLE		8,076	0	0
INMUNE BIO INC	COM	45782T105	2,775	233,576	SH		SOLE		233,576	0	0
INTERCEPT PHARMACEUTICALS IN	COM	45845P108	808	35,000	SH		SOLE		35,000	0	0
INTERCEPT PHARMACEUTICALS IN	COM	45845P108	2,308	100,000	SH	Call	SOLE		100,000	0	0
INTRA CELLULAR THERAPIES INC	COM	46116X101	2,545	75,000	SH	Put	SOLE		75,000	0	0
INTRA CELLULAR THERAPIES INC	COM	46116X101	7,125	210,000	SH	Call	SOLE		210,000	0	0
INTRA CELLULAR THERAPIES INC	COM	46116X101	11,231	330,989	SH		SOLE		330,989	0	0
INVENTIVA SA	ADS	46124U107	215	15,000	SH		SOLE		15,000	0	0
INVESCO QQQ TR	UNIT SER 1	46090E103	63,826	200,000	SH	Put	SOLE		200,000	0	0
INVITAE CORP	COM	46185L103	7,642	200,000	SH	Put	SOLE		200,000	0	0
IONIS PHARMACEUTICALS INC	COM	462222100	4,047	90,000	SH	Call	SOLE		90,000	0	0
IOVANCE BIOTHERAPEUTICS INC	COM	462260100	6,332	200,000	SH	Put	SOLE		200,000	0	0
ISHARES TR	20 YR TR BD ETF	464287432	54,180	400,000	SH	Call	SOLE		400,000	0	0
ISHARES TR	20 YR TR BD ETF	464287432	40,635	300,000	SH	Put	SOLE		300,000	0	0
ISHARES TR	PHLX SEMICND ETF	464287523	42,398	100,000	SH	Put	SOLE		100,000	0	0
ISHARES TR	RUSSELL 2000 ETF	464287655	99,422	450,000	SH	Put	SOLE		450,000	0	0
ISHARES TR	NASDAQ BIOTECH	464287556	37,640	250,000	SH	Call	SOLE		250,000	0	0
JAZZ PHARMACEUTICALS PLC	SHS USD	G50871105	16,437	100,000	SH	Call	SOLE		100,000	0	0
KADMON HLDGS INC	COM	48283N106	3,644	936,615	SH		SOLE		936,615	0	0
KALVISTA PHARMACEUTICALS INC	COM	483497103	7,629	296,965	SH		SOLE		296,965	0	0
KARYOPHARM THERAPEUTICS INC	COM	48576U106	9	791	SH		SOLE		791	0	0
KINIKSA PHARMACEUTICALS LTD	COM CL A	G5269C101	949	51,273	SH		SOLE		51,273	0	0
KINNATE BIOPHARMA INC	COM	49705R105	62	2,000	SH		SOLE		2,000	0	0
KURA ONCOLOGY INC	COM	50127T109	441	15,603	SH		SOLE		15,603	0	0
KURA ONCOLOGY INC	COM	50127T109	3,957	140,000	SH	Call	SOLE		140,000	0	0
LARIMAR THERAPEUTICS INC	COM	517125100	6,215	425,384	SH		SOLE		425,384	0	0
LEGEND BIOTECH CORP	SPONSORED ADS	52490G102	44	1,500	SH	Put	SOLE		1,500	0	0
LIFESCI ACQUISITION II CORP	COM	53229E103	5,196	512,450	SH		SOLE		512,450	0	0
LILLY ELI & CO	COM	532457108	23,352	125,000	SH		SOLE		125,000	0	0
LIQUIDIA CORPORATION	COM NEW	53635D202	2,560	951,400	SH		SOLE		951,400	0	0
LYRA THERAPEUTICS INC	COM	55234L105	9,048	780,728	SH		SOLE		780,728	0	0
MACROGENICS INC	COM	556099109	15,940	500,469	SH		SOLE		500,469	0	0
MACROGENICS INC	COM	556099109	6,371	200,000	SH	Call	SOLE		200,000	0	0
MADRIGAL PHARMACEUTICALS INC	COM	558868105	2,768	23,654	SH		SOLE		23,654	0	0
MEREO BIOPHARMA GROUP PLC	ADS	589492107	419	1,146,308	SH		SOLE		1,146,308	0	0
MERSANA THERAPEUTICS INC	COM	59045L106	3,237	200,000	SH	Call	SOLE		200,000	0	0
MERUS N V	COM	N5749R100	2,322	111,223	SH		SOLE		111,223	0	0
MILESTONE PHARMACEUTICALS IN	COM	59935V107	10,633	1,836,545	SH		SOLE		1,836,545	0	0
MILLENDO THERAPEUTICS INC	COM	60040X103	1,617	1,348,021	SH		SOLE		1,348,021	0	0
MIRATI THERAPEUTICS INC	COM	60468T105	16,188	94,500	SH	Call	SOLE		94,500	0	0
MIRATI THERAPEUTICS INC	COM	60468T105	27,751	162,000	SH	Put	SOLE		162,000	0	0
MODERNA INC	COM	60770K107	78,568	600,000	SH	Put	SOLE		600,000	0	0
MODERNA INC	COM	60770K107	13,094	100,000	SH	Call	SOLE		100,000	0	0
MORPHIC HLDG INC	COM	61775R105	3,160	49,925	SH		SOLE		49,925	0	0
MUSTANG BIO INC	COM	62818Q104	1,747	526,003	SH		SOLE		526,003	0	0
NEXTCURE INC	COM	65343E108	4,544	453,952	SH		SOLE		453,952	0	0
NOVAVAX INC	COM NEW	670002401	478	2,636	SH		SOLE		2,636	0	0
NOVAVAX INC	COM NEW	670002401	12,693	70,000	SH	Call	SOLE		70,000	0	0
NOVAVAX INC	COM NEW	670002401	35,483	195,700	SH	Put	SOLE		195,700	0	0
NUVATION BIO INC	COM CL A	67080N101	2,613	250,000	SH		SOLE		250,000	0	0
OCULAR THERAPEUTIX INC	COM	67576A100	6,885	419,573	SH		SOLE		419,573	0	0
OCULAR THERAPEUTIX INC	COM	67576A100	4,301	262,100	SH	Call	SOLE		262,100	0	0
OCUPHIRE PHARMA INC	COM	67577R102	693	119,551	SH		SOLE		119,551	0	0
ODONATE THERAPEUTICS INC	COM	676079106	4,571	1,336,412	SH		SOLE		1,336,412	0	0
ONCONOVA THERAPEUTICS INC	COM PAR	68232V405	1,144	1,145,426	SH		SOLE		1,145,426	0	0
ONCTERNAL THERAPEUTICS INC	COM	68236P107	3,831	460,323	SH		SOLE		460,323	0	0
ORCHARD THERAPEUTICS PLC	ADS	68570P101	1,815	250,000	SH		SOLE		250,000	0	0
OVID THERAPEUTICS INC	COM	690469101	4,522	1,124,872	SH		SOLE		1,124,872	0	0
PANBELA THERAPEUTICS INC	COM	69833Q100	1,363	345,013	SH		SOLE		345,013	0	0
PASSAGE BIO INC	COM	702712100	2,550	145,858	SH		SOLE		145,858	0	0
PDS BIOTECHNOLOGY CORP	COM	70465T107	1,745	383,373	SH		SOLE		383,373	0	0
PHATHOM PHARMACEUTICALS INC	COM	71722W107	3,757	100,000	SH		SOLE		100,000	0	0
PLIANT THERAPEUTICS INC	COM	729139105	4,275	108,700	SH	��	SOLE		108,700	0	0
POSEIDA THERAPEUTICS INC	COM	73730P108	820	85,837	SH		SOLE		85,837	0	0
PROTARA THERAPEUTICS INC	COM STK	74365U107	10,223	649,542	SH		SOLE		649,542	0	0
PROTHENA CORP PLC	SHS	G72800108	10,989	437,430	SH		SOLE		437,430	0	0
PUMA BIOTECHNOLOGY INC	COM	74587V107	533	54,901	SH		SOLE		54,901	0	0
RAPT THERAPEUTICS INC	COM	75382E109	5,550	250,000	SH	Call	SOLE		250,000	0	0
REATA PHARMACEUTICALS INC	CL A	75615P103	10,459	104,900	SH	Put	SOLE		104,900	0	0
REATA PHARMACEUTICALS INC	CL A	75615P103	60	600	SH		SOLE		600	0	0
REGULUS THERAPEUTICS INC	COM NEW	75915K200	1,943	1,245,989	SH		SOLE		1,245,989	0	0
RELMADA THERAPEUTICS INC	COM	75955J402	6,958	197,600	SH	Call	SOLE		197,600	0	0
RELMADA THERAPEUTICS INC	COM	75955J402	10,218	290,207	SH		SOLE		290,207	0	0
REVOLUTION MEDICINES INC	COM	76155X100	6,882	150,000	SH	Call	SOLE		150,000	0	0
ROCKET PHARMACEUTICALS INC	COM	77313F106	61	1,400	SH		SOLE		1,400	0	0
RUBIUS THERAPEUTICS INC	COM	78116T103	1,326	50,000	SH		SOLE		50,000	0	0
SAGE THERAPEUTICS INC	COM	78667J108	18,713	250,000	SH	Put	SOLE		250,000	0	0
SAGE THERAPEUTICS INC	COM	78667J108	7,805	104,300	SH	Call	SOLE		104,300	0	0
SAGE THERAPEUTICS INC	COM	78667J108	6,823	91,151	SH		SOLE		91,151	0	0
SAREPTA THERAPEUTICS INC	COM	803607100	10	134	SH		SOLE		134	0	0
SAREPTA THERAPEUTICS INC	COM	803607100	7,453	100,000	SH	Call	SOLE		100,000	0	0
SAREPTA THERAPEUTICS INC	COM	803607100	33,978	455,900	SH	Put	SOLE		455,900	0	0
SATSUMA PHARMACEUTICALS INC	COM	80405P107	3,997	676,294	SH		SOLE		676,294	0	0
SAVARA INC	COM	805111101	3,566	1,714,366	SH		SOLE		1,714,366	0	0
SCHOLAR ROCK HLDG CORP	COM	80706P103	3,397	67,059	SH		SOLE		67,059	0	0
SCHOLAR ROCK HLDG CORP	COM	80706P103	1,433	28,300	SH	Call	SOLE		28,300	0	0
SCHRODINGER INC	COM	80810D103	7,628	100,000	SH	Put	SOLE		100,000	0	0
SCPHARMACEUTICALS INC	COM	810648105	8,703	1,308,699	SH		SOLE		1,308,699	0	0
SEELOS THERAPEUTICS INC	COM	81577F109	3,585	718,284	SH		SOLE		718,284	0	0
SELECT SECTOR SPDR TR	SBI INT-INDS	81369Y704	49,226	500,000	SH	Call	SOLE		500,000	0	0
SELECT SECTOR SPDR TR	SBI INT-FINL	81369Y605	37,773	1,109,400	SH	Call	SOLE		1,109,400	0	0
SELECT SECTOR SPDR TR	SBI INT-UTILS	81369Y886	12,809	200,000	SH	Call	SOLE		200,000	0	0
SELLAS LIFE SCIENCES GROUP I	COM NEW	81642T209	410	48,053	SH		SOLE		48,053	0	0
SERES THERAPEUTICS INC	COM	81750R102	7,206	350,000	SH		SOLE		350,000	0	0
SERES THERAPEUTICS INC	COM	81750R102	16,061	780,000	SH	Call	SOLE		780,000	0	0
SHATTUCK LABS INC	COM	82024L103	5,566	190,330	SH		SOLE		190,330	0	0
SIERRA ONCOLOGY INC	COM NEW	82640U404	7,671	445,188	SH		SOLE		445,188	0	0
SOLENO THERAPEUTICS INC	COM NEW	834203200	155	122,462	SH		SOLE		122,462	0	0
SOLID BIOSCIENCES INC	COM	83422E105	131	23,617	SH		SOLE		23,617	0	0
SORRENTO THERAPEUTICS INC	COM NEW	83587F202	1,372	165,900	SH		SOLE		165,900	0	0
SPDR S&P 500 ETF TR	TR UNIT	78462F103	217,981	550,000	SH	Put	SOLE		550,000	0	0
SPDR SER TR	S&P BIOTECH	78464A870	128,866	950,000	SH	Put	SOLE		950,000	0	0
SPDR SER TR	S&P BIOTECH	78464A870	47,477	350,000	SH	Call	SOLE		350,000	0	0
STEALTH BIOTHERAPEUTICS CORP	SPONSORED ADS	85789A105	1,237	788,014	SH		SOLE		788,014	0	0
STOKE THERAPEUTICS INC	COM	86150R107	3,962	102,000	SH	Put	SOLE		102,000	0	0
STRONGBRIDGE BIOPHARMA PLC	SHS USD	G85347105	3,203	1,160,450	SH		SOLE		1,160,450	0	0
SUTRO BIOPHARMA INC	COM	869367102	4,553	200,000	SH	Call	SOLE		200,000	0	0
SUTRO BIOPHARMA INC	COM	869367102	3,081	135,360	SH		SOLE		135,360	0	0
SYNDAX PHARMACEUTICALS INC	COM	87164F105	914	40,913	SH		SOLE		40,913	0	0
SYNLOGIC INC	COM	87166L100	5,343	1,492,614	SH		SOLE		1,492,614	0	0
SYROS PHARMACEUTICALS INC	COM	87184Q107	748	100,000	SH		SOLE		100,000	0	0
TCR2 THERAPEUTICS INC	COM	87808K106	3,013	136,486	SH		SOLE		136,486	0	0
TELADOC HEALTH INC	COM	87918A105	1,181	6,500	SH	Put	SOLE		6,500	0	0
TG THERAPEUTICS INC	COM	88322Q108	4,820	100,000	SH	Put	SOLE		100,000	0	0
TRACON PHARMACEUTICALS INC	COM NEW	89237H209	22,360	2,716,840	SH		SOLE		2,716,840	0	0
TRANSLATE BIO INC	COM	89374L104	4,122	250,000	SH	Put	SOLE		250,000	0	0
TRICIDA INC	COM	89610F101	4,102	775,294	SH		SOLE		775,294	0	0
TRILLIUM THERAPEUTICS INC	COM NEW	89620X506	2,148	200,000	SH	Call	SOLE		200,000	0	0
TWIST BIOSCIENCE CORP	COM	90184D100	14,864	120,000	SH	Put	SOLE		120,000	0	0
ULTRAGENYX PHARMACEUTICAL IN	COM	90400D108	2,094	18,400	SH	Put	SOLE		18,400	0	0
UNITED THERAPEUTICS CORP DEL	COM	91307C102	17,562	105,000	SH	Call	SOLE		105,000	0	0
UNUM THERAPEUTICS INC	COM	19240Q201	367	41,762	SH		SOLE		41,762	0	0
VALLON PHARMACEUTICALS INC	COM	92023M101	649	140,000	SH		SOLE		140,000	0	0
VANECK VECTORS ETF TR	SEMICONDUCTOR ET	92189F676	24,354	100,000	SH	Put	SOLE		100,000	0	0
VASCULAR BIOGENICS LTD	COM	M96883109	1,601	800,811	SH		SOLE		800,811	0	0
VAXCYTE INC	COM	92243G108	9,897	501,110	SH		SOLE		501,110	0	0
VERASTEM INC	COM	92337C104	6,655	2,694,394	SH		SOLE		2,694,394	0	0
VERICEL CORP	COM	92346J108	439	7,900	SH	Call	SOLE		7,900	0	0
VERTEX PHARMACEUTICALS INC	COM	92532F100	42,977	200,000	SH	Put	SOLE		200,000	0	0
VIKING THERAPEUTICS INC	COM	92686J106	4,584	724,754	SH		SOLE		724,754	0	0
VINCERX PHARMA INC	COM NEW	92731L106	8,467	438,684	SH		SOLE		438,684	0	0
VIR BIOTECHNOLOGY INC	COM	92764N102	12,816	250,000	SH	Put	SOLE		250,000	0	0
VIRACTA THERAPEUTICS INC	COM	92765F108	1,439	155,599	SH		SOLE		155,599	0	0
VISTAGEN THERAPEUTICS INC	COM NEW	92840H202	6,147	2,885,952	SH		SOLE		2,885,952	0	0
WAVE LIFE SCIENCES LTD	SHS	Y95308105	1,403	250,000	SH	Call	SOLE		250,000	0	0
X4 PHARMACEUTICALS INC	COM	98420X103	10,639	1,235,678	SH		SOLE		1,235,678	0	0
X4 PHARMACEUTICALS INC - PIPE	COM	98420X103	11,876	1,379,310	SH		SOLE		1,379,310	0	0
XENON PHARMACEUTICALS INC	COM	98420N105	2,687	150,100	SH	Call	SOLE		150,100	0	0
XENON PHARMACEUTICALS INC	COM	98420N105	11,467	640,576	SH		SOLE		640,576	0	0
YUMANITY THERAPEUTICS INC	COM	98872L102	3,972	219,470	SH		SOLE		219,470	0	0
ZAI LAB LTD	ADR	98887Q104	2,249	17,000	SH		SOLE		17,000	0	0
ZOGENIX INC	COM NEW	98978L204	16,591	850,000	SH	Call	SOLE		850,000	0	0
ZOGENIX INC	COM NEW	98978L204	2,422	124,091	SH		SOLE		124,091	0	0