Ikarian Capital 13F-HR Quarterly holdings report by institutional manager

The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

OMB APPROVAL

OMB Number:		3235-0006
Expires:	Oct 31, 2018
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COLUMN 1	COLUMN 2	COLUMN 3	COLUMN 4	COLUMN 5			COLUMN 6	COLUMN 7	COLUMN 8
			VALUE	SHRS OR	SH/	PUT/	INVESTMENT	OTHER	VOTING AUTHORITY
NAME OF ISSUER	TITLE OF CLASS	CUSIP	(x$1000)	PRN AMT	PRN	CALL	DISCRETION	MANAGER	SOLE	SHARED	NONE
2SEVENTY BIO INC	COMMON STOCK	901384107	2	93	SH		SOLE		93	0	0
AADI BIOSCIENCE INC	COM	00032Q104	4,744	196,408	SH		SOLE		196,408	0	0
ACADIA PHARMACEUTICALS INC	COM	004225108	42	1,765	SH		SOLE		1,765	0	0
ACLARIS THERAPEUTICS INC	COM	00461U105	156	10,785	SH		SOLE		10,785	0	0
ADICET BIO INC	COM	007002108	3,498	200,000	SH	Call	SOLE		200,000	0	0
ADICET BIO INC	COM	007002108	8,350	477,418	SH		SOLE		477,418	0	0
AGENUS INC	COM NEW	00847G705	332	103,192	SH		SOLE		103,192	0	0
AILERON THERAPEUTICS INC	COM	00887A105	1,556	2,763,583	SH		SOLE		2,763,583	0	0
ALLAKOS INC	COM	01671P100	2,135	218,000	SH	Call	SOLE		218,000	0	0
ALLAKOS INC	COM	01671P100	366	37,400	SH	Put	SOLE		37,400	0	0
ALNYLAM PHARMACEUTICALS INC	COM	02043Q107	204	1,195	SH		SOLE		1,195	0	0
ALNYLAM PHARMACEUTICALS INC	COM	02043Q107	30,237	178,300	SH	Call	SOLE		178,300	0	0
ALTAMIRA THERAPEUTICS LTD	SHS	G0360L100	553	304,791	SH		SOLE		304,791	0	0
AMICUS THERAPEUTICS INC	COM	03152W109	1,896	164,174	SH		SOLE		164,174	0	0
AMRYT PHARMA PLC	SPONSORED ADS	03217L106	72	34,131	SH		SOLE		34,131	0	0
ANEBULO PHARMACEUTICALS INC	COM	034569103	1,071	172,309	SH		SOLE		172,309	0	0
APELLIS PHARMACEUTICALS INC	COM	03753U106	9,455	200,000	SH	Call	SOLE		200,000	0	0
APPLIED GENETIC TECHNOLOGIES	COM	03820J100	742	390,394	SH		SOLE		390,394	0	0
APTOSE BIOSCIENCES INC	COM NEW	03835T200	138	102,089	SH		SOLE		102,089	0	0
ARCUS BIOSCIENCES INC	COM	03969F109	5,044	124,600	SH	Put	SOLE		124,600	0	0
ARENA PHARMACEUTICALS INC	COM NEW	040047607	2,072	22,300	SH	Call	SOLE		22,300	0	0
ARENA PHARMACEUTICALS INC	COM NEW	040047607	200	2,161	SH		SOLE		2,161	0	0
ASCENDIS PHARMA A/S	SPONSORED ADR	04351P101	1,130	8,400	SH		SOLE		8,400	0	0
ASLAN PHARMACEUTICALS LTD	ADS	04522R101	187	917,348	SH		SOLE		917,348	0	0
ASSEMBLY BIOSCIENCES INC	COM	045396108	501	214,861	SH		SOLE		214,861	0	0
ASTRIA THERAPEUTICS INC	COM	04635X102	473	87,580	SH		SOLE		87,580	0	0
ATEA PHARMACEUTICALS INC	COM	04683R106	1,043	116,600	SH	Call	SOLE		116,600	0	0
ATHENEX INC	COM	04685N103	103	76,139	SH		SOLE		76,139	0	0
ATHIRA PHARMA INC	COM	04746L104	11,207	860,000	SH	Call	SOLE		860,000	0	0
ATYR PHARMA INC	COM NEW	002120202	262	35,048	SH		SOLE		35,048	0	0
AURINIA PHARMACEUTICALS INC	COM	05156V102	1,883	82,335	SH		SOLE		82,335	0	0
AUTOLUS THERAPEUTICS PLC	SPON ADS	05280R100	2,827	544,819	SH		SOLE		544,819	0	0
AVALO THERAPEUTICS INC	COM	05338F108	1,223	718,705	SH		SOLE		718,705	0	0
AYALA PHARMACEUTICALS INC	COM	05465V108	5,696	669,271	SH		SOLE		669,271	0	0
BAUDAX BIO INC	COM	07160F107	21	95,059	SH		SOLE		95,059	0	0
BCLS ACQUISITION CORP	COM CL A	G0904B105	728	73,789	SH		SOLE		73,789	0	0
BELLICUM PHARMACEUTICALS INC	COM NEW	079481404	739	496,756	SH		SOLE		496,756	0	0
BELLUS HEALTH INC NEW	COM NEW	07987C204	402	50,000	SH		SOLE		50,000	0	0
BICYCLE THERAPEUTICS PLC	SPONSORED ADS	088786108	37,321	613,126	SH		SOLE		613,126	0	0
BIOGEN INC	COM	09062X103	7,087	29,533	SH		SOLE		29,533	0	0
BIOMARIN PHARMACEUTICAL INC	COM	09061G101	8,836	100,000	SH	Call	SOLE		100,000	0	0
BIOXCEL THERAPEUTICS INC	COM	09075P105	104	5,167	SH		SOLE		5,167	0	0
BLACK DIAMOND THERAPEUTICS I	COM	09203E105	801	150,484	SH		SOLE		150,484	0	0
BLUEBIRD BIO INC	COM	09609G100	2	287	SH		SOLE		287	0	0
BRAINSTORM CELL THERAPEUTICS	COM NEW	10501E201	1,159	289,550	SH		SOLE		289,550	0	0
BRIDGEBIO PHARMA INC	COM	10806X102	25	1,500	SH		SOLE		1,500	0	0
BRIDGEBIO PHARMA INC	COM	10806X102	15,173	909,700	SH	Put	SOLE		909,700	0	0
BRIDGEBIO PHARMA INC	COM	10806X102	1,668	100,000	SH	Call	SOLE		100,000	0	0
BRIGHT MINDS BIOSCIENCES INC	COM	10919W108	317	100,000	SH		SOLE		100,000	0	0
CABALETTA BIO INC	COM	12674W109	3,678	970,398	SH		SOLE		970,398	0	0
CABALETTA BIO INC	COM	12674W109	1,603	423,000	SH	Call	SOLE		423,000	0	0
CASI PHARMACEUTICALS INC	COM	14757U109	978	1,223,067	SH		SOLE		1,223,067	0	0
CATALYST BIOSCIENCES INC	COM NEW	14888D208	416	454,346	SH		SOLE		454,346	0	0
CELLDEX THERAPEUTICS INC NEW	COM NEW	15117B202	17,433	451,200	SH	Put	SOLE		451,200	0	0
CELLDEX THERAPEUTICS INC NEW	COM NEW	15117B202	16,198	419,216	SH		SOLE		419,216	0	0
CELLDEX THERAPEUTICS INC NEW	COM NEW	15117B202	22,946	593,800	SH	Call	SOLE		593,800	0	0
CHEMOMAB THERAPEUTICS LTD	SPONSORED ADS	16385C104	1,829	265,264	SH		SOLE		265,264	0	0
CHIMERIX INC	COM	16934W106	5,114	795,410	SH		SOLE		795,410	0	0
CLENE INC	COMMON STOCK	185634102	2,006	489,321	SH		SOLE		489,321	0	0
CLOVIS ONCOLOGY INC	COM	189464100	3,016	1,112,669	SH		SOLE		1,112,669	0	0
CODIAK BIOSCIENCES INC	COM	192010106	554	49,680	SH		SOLE		49,680	0	0
COMPASS THERAPEUTICS INC	COM	20454B104	222	70,000	SH		SOLE		70,000	0	0
CONNECT BIOPHARMA HLDGS LTD	ADS	207523101	1,350	262,237	SH		SOLE		262,237	0	0
CORBUS PHARMACEUTICALS HLDGS	COM	21833P103	584	948,526	SH		SOLE		948,526	0	0
CORVUS PHARMACEUTICALS INC	COM	221015100	1,163	482,610	SH		SOLE		482,610	0	0
CYCLACEL PHARMACEUTICALS INC	COM	23254L603	385	99,422	SH		SOLE		99,422	0	0
CYCLERION THERAPEUTICS INC	COM	23255M105	866	502,627	SH		SOLE		502,627	0	0
DBV TECHNOLOGIES S A	SPONSORED ADR	23306J101	1,078	310,110	SH		SOLE		310,110	0	0
DECIPHERA PHARMACEUTICALS IN	COM	24344T101	291	29,800	SH	Call	SOLE		29,800	0	0
DECIPHERA PHARMACEUTICALS IN	COM	24344T101	8	800	SH	Put	SOLE		800	0	0
DIAMEDICA THERAPEUTICS INC	COM NEW	25253X207	779	209,082	SH		SOLE		209,082	0	0
ELEDON PHARMACEUTICALS INC	COM	28617K101	1,519	344,578	SH		SOLE		344,578	0	0
ENVERIC BIOSCIENCES INC	COM NEW	29405E109	372	400,000	SH		SOLE		400,000	0	0
EYEPOINT PHARMACEUTICALS INC	COM NEW	30233G209	262	21,427	SH		SOLE		21,427	0	0
FATE THERAPEUTICS INC	COM	31189P102	528	9,038	SH		SOLE		9,038	0	0
FINCH THERAPEUTICS GROUP INC	COM	31773D101	3,148	315,732	SH		SOLE		315,732	0	0
FRAZIER LIFESCIENCES ACQU CO	UNIT 12/09/2025	G3710A121	9	941	SH		SOLE		941	0	0
GALAPAGOS NV	SPON ADR	36315X101	4,861	86,865	SH		SOLE		86,865	0	0
GAMIDA CELL LTD	SHS	M47364100	79	31,029	SH		SOLE		31,029	0	0
GEMINI THERAPEUTICS INC	COM	36870G105	1,225	421,050	SH		SOLE		421,050	0	0
GENOCEA BIOSCIENCES INC	COM NEW	372427401	228	196,821	SH		SOLE		196,821	0	0
GLOBAL BLOOD THERAPEUTICS IN	COM	37890U108	4,803	164,082	SH		SOLE		164,082	0	0
GOSSAMER BIO INC	COM	38341P102	2,262	200,000	SH	Call	SOLE		200,000	0	0
GOSSAMER BIO INC	COM	38341P102	13,199	1,166,933	SH		SOLE		1,166,933	0	0
HARPOON THERAPEUTICS INC	COM	41358P106	840	111,292	SH		SOLE		111,292	0	0
HEPION PHARMACEUTICALS INC	COM	426897104	630	553,273	SH		SOLE		553,273	0	0
HORIZON THERAPEUTICS PUB L	SHS	G46188101	8,153	75,661	SH		SOLE		75,661	0	0
HORIZON THERAPEUTICS PUB L	SHS	G46188101	26,607	246,900	SH	Call	SOLE		246,900	0	0
IGM BIOSCIENCES INC	COM	449585108	44	1,500	SH		SOLE		1,500	0	0
IMMATICS N.V	SHS	N44445109	9,913	737,546	SH		SOLE		737,546	0	0
IMMUNOPRECISE ANTIBODIES LTD	COM NEW	45257F200	395	73,882	SH		SOLE		73,882	0	0
INFLARX NV	COM	N44821101	1,577	331,048	SH		SOLE		331,048	0	0
INHIBRX INC	COM	45720L107	3,529	80,800	SH	Call	SOLE		80,800	0	0
INHIBRX INC	COM	45720L107	6,542	149,850	SH		SOLE		149,850	0	0
INTERCEPT PHARMACEUTICALS IN	COM	45845P108	18	1,100	SH	Put	SOLE		1,100	0	0
INTERCEPT PHARMACEUTICALS IN	COM	45845P108	562	34,565	SH		SOLE		34,565	0	0
INVENTIVA SA	ADS	46124U107	197	14,748	SH		SOLE		14,748	0	0
IOVANCE BIOTHERAPEUTICS INC	COM	462260100	3,294	172,521	SH		SOLE		172,521	0	0
IOVANCE BIOTHERAPEUTICS INC	COM	462260100	3,742	196,000	SH	Put	SOLE		196,000	0	0
ISHARES TR	ISHARES BIOTECH	464287556	3,666	24,022	SH		SOLE		24,022	0	0
IVERIC BIO INC	COM	46583P102	778	46,519	SH		SOLE		46,519	0	0
KALVISTA PHARMACEUTICALS INC	COM	483497103	484	36,576	SH		SOLE		36,576	0	0
KARYOPHARM THERAPEUTICS INC	COM	48576U106	5	785	SH		SOLE		785	0	0
KEZAR LIFE SCIENCES INC	COM	49372L100	17,069	1,020,917	SH		SOLE		1,020,917	0	0
KEZAR LIFE SCIENCES INC	COM	49372L100	2,830	169,300	SH	Call	SOLE		169,300	0	0
KINNATE BIOPHARMA INC	COM	49705R105	35	1,990	SH		SOLE		1,990	0	0
KODIAK SCIENCES INC	COM	50015M109	14,235	167,900	SH	Call	SOLE		167,900	0	0
LARIMAR THERAPEUTICS INC	COM	517125100	510	47,193	SH		SOLE		47,193	0	0
LIQUIDIA CORPORATION	COM NEW	53635D202	1,583	325,445	SH		SOLE		325,445	0	0
LYRA THERAPEUTICS INC	COM	55234L105	1,719	394,536	SH		SOLE		394,536	0	0
MACROGENICS INC	COM	556099109	2,506	156,047	SH		SOLE		156,047	0	0
MADRIGAL PHARMACEUTICALS INC	COM	558868105	2,008	23,700	SH		SOLE		23,700	0	0
MAXCYTE INC	COM	57777K106	1,325	130,000	SH		SOLE		130,000	0	0
MEREO BIOPHARMA GROUP PLC	ADS	589492107	307	853,680	SH		SOLE		853,680	0	0
MERUS N V	COM	N5749R100	1,619	50,907	SH		SOLE		50,907	0	0
MILESTONE PHARMACEUTICALS IN	COM	59935V107	11,464	1,750,043	SH		SOLE		1,750,043	0	0
MIND MEDICINE MINDMED INC	COM SUB VTG	60255C109	138	100,000	SH		SOLE		100,000	0	0
MIRATI THERAPEUTICS INC	COM	60468T105	191	1,300	SH	Put	SOLE		1,300	0	0
MUSTANG BIO INC	COM	62818Q104	840	506,033	SH		SOLE		506,033	0	0
MYMD PHARMACEUTICALS INC	COM	62856X102	751	124,000	SH		SOLE		124,000	0	0
NEKTAR THERAPEUTICS	COM	640268108	3,378	250,000	SH	Call	SOLE		250,000	0	0
NEXTCURE INC	COM	65343E108	804	134,055	SH		SOLE		134,055	0	0
NOVAVAX INC	COM NEW	670002401	183	1,283	SH		SOLE		1,283	0	0
NUVATION BIO INC	COM CL A	67080N101	1,700	200,000	SH		SOLE		200,000	0	0
OCULAR THERAPEUTIX INC	COM	67576A100	191	27,551	SH		SOLE		27,551	0	0
OCUPHIRE PHARMA INC	COM	67577R102	442	118,063	SH		SOLE		118,063	0	0
ODONATE THERAPEUTICS INC	COM	676079106	1,810	1,340,631	SH		SOLE		1,340,631	0	0
ONCONOVA THERAPEUTICS INC	COM NEW	68232V801	37	15,063	SH		SOLE		15,063	0	0
ONCTERNAL THERAPEUTICS INC	COM	68236P107	451	199,180	SH		SOLE		199,180	0	0
ORCHARD THERAPEUTICS PLC	ADS	68570P101	195	148,131	SH		SOLE		148,131	0	0
OTONOMY INC	COM	68906L105	433	208,306	SH		SOLE		208,306	0	0
OVID THERAPEUTICS INC	COM	690469101	2,264	705,082	SH		SOLE		705,082	0	0
PANBELA THERAPEUTICS INC	COM	69833Q100	592	338,382	SH		SOLE		338,382	0	0
PARDES BIOSCIENCES INC	COM	69945Q105	6,547	400,000	SH		SOLE		400,000	0	0
PASSAGE BIO INC	COM	702712100	431	67,849	SH		SOLE		67,849	0	0
PDS BIOTECHNOLOGY CORP	COM	70465T107	28	3,495	SH		SOLE		3,495	0	0
PHATHOM PHARMACEUTICALS INC	COM	71722W107	1,467	74,560	SH		SOLE		74,560	0	0
PLIANT THERAPEUTICS INC	COM	729139105	1,170	86,712	SH		SOLE		86,712	0	0
PROTAGONIST THERAPEUTICS INC	COM	74366E102	4,341	126,900	SH	Call	SOLE		126,900	0	0
PROTARA THERAPEUTICS INC	COM STK	74365U107	1,885	279,256	SH		SOLE		279,256	0	0
PUMA BIOTECHNOLOGY INC	COM	74587V107	152	49,843	SH		SOLE		49,843	0	0
QUANTUM SI INC	COM CL A	74765K105	1,136	144,406	SH		SOLE		144,406	0	0
RAFAEL HLDGS INC	COM CL B	75062E106	370	72,515	SH		SOLE		72,515	0	0
RAFAEL HLDGS INC	COM CL B	75062E106	510	100,000	SH	Put	SOLE		100,000	0	0
REATA PHARMACEUTICALS INC	CL A	75615P103	2,637	100,000	SH	Put	SOLE		100,000	0	0
REATA PHARMACEUTICALS INC	CL A	75615P103	5,274	200,000	SH	Call	SOLE		200,000	0	0
REGULUS THERAPEUTICS INC	COM NEW	75915K200	388	1,228,416	SH		SOLE		1,228,416	0	0
RELMADA THERAPEUTICS INC	COM	75955J402	467	20,743	SH		SOLE		20,743	0	0
RENEO PHARMACEUTICALS INC	COM	75974E103	1,497	175,000	SH		SOLE		175,000	0	0
RENOVACOR INC	COM	75989E106	2,641	342,902	SH		SOLE		342,902	0	0
RIGEL PHARMACEUTICALS INC	COM NEW	766559603	1,164	439,356	SH		SOLE		439,356	0	0
SAGE THERAPEUTICS INC	COM	78667J108	192	4,500	SH	Call	SOLE		4,500	0	0
SAREPTA THERAPEUTICS INC	COM	803607100	35,962	399,400	SH	Call	SOLE		399,400	0	0
SATSUMA PHARMACEUTICALS INC	COM	80405P107	2,831	629,384	SH		SOLE		629,384	0	0
SAVARA INC	COM	805111101	1,910	1,539,691	SH		SOLE		1,539,691	0	0
SCPHARMACEUTICALS INC	COM	810648105	4,525	901,362	SH		SOLE		901,362	0	0
SEELOS THERAPEUTICS INC	COM	81577F109	398	244,171	SH		SOLE		244,171	0	0
SERES THERAPEUTICS INC	COM	81750R102	6,630	795,903	SH		SOLE		795,903	0	0
SIERRA ONCOLOGY INC	COM NEW	82640U404	12,370	569,029	SH		SOLE		569,029	0	0
SOLENO THERAPEUTICS INC	COM NEW	834203200	50	121,694	SH		SOLE		121,694	0	0
SOLID BIOSCIENCES INC	COM	83422E105	911	521,155	SH		SOLE		521,155	0	0
SPDR SER TR	S&P BIOTECH	78464A870	10,345	92,400	SH	Call	SOLE		92,400	0	0
SPDR SER TR	S&P BIOTECH	78464A870	60,727	542,400	SH	Put	SOLE		542,400	0	0
STEALTH BIOTHERAPEUTICS CORP	SPONSORED ADS	85789A105	397	478,561	SH		SOLE		478,561	0	0
SYNAPTOGENIX INC	COM NEW	87167T201	1,239	145,629	SH		SOLE		145,629	0	0
SYNLOGIC INC	COM	87166L100	1,171	483,818	SH		SOLE		483,818	0	0
TANGO THERAPEUTICS INC	COM	87583X109	56	5,180	SH		SOLE		5,180	0	0
TEMPEST THERAPEUTICS INC	COM	87978U108	310	58,803	SH		SOLE		58,803	0	0
TENAX THERAPEUTICS INC	COM NEW	88032L209	722	694,195	SH		SOLE		694,195	0	0
TG THERAPEUTICS INC	COM	88322Q108	1,914	100,739	SH		SOLE		100,739	0	0
TG THERAPEUTICS INC	COM	88322Q108	1,873	98,600	SH	Put	SOLE		98,600	0	0
TRACON PHARMACEUTICALS INC	COM NEW	89237H209	7,454	2,691,110	SH		SOLE		2,691,110	0	0
VALLON PHARMACEUTICALS INC	COM	92023M101	1,184	198,085	SH		SOLE		198,085	0	0
VASCULAR BIOGENICS LTD	COM	M96883109	1,558	790,838	SH		SOLE		790,838	0	0
VAXCYTE INC	COM	92243G108	7,021	295,111	SH		SOLE		295,111	0	0
VERASTEM INC	COM	92337C104	1,308	637,371	SH		SOLE		637,371	0	0
VIKING THERAPEUTICS INC	COM	92686J106	2,303	500,642	SH		SOLE		500,642	0	0
VISTAGEN THERAPEUTICS INC	COM NEW	92840H202	927	475,693	SH		SOLE		475,693	0	0
VTV THERAPEUTICS INC	CL A	918385105	697	700,000	SH		SOLE		700,000	0	0
WAVE LIFE SCIENCES LTD	SHS	Y95308105	3,119	993,481	SH		SOLE		993,481	0	0
X4 PHARMACEUTICALS INC	COM	98420X103	5,186	2,264,491	SH		SOLE		2,264,491	0	0
XENON PHARMACEUTICALS INC	COM	98420N105	5,597	179,138	SH		SOLE		179,138	0	0
YUMANITY THERAPEUTICS INC	COM	98872L102	678	228,761	SH		SOLE		228,761	0	0
ZAI LAB LTD	ADR	98887Q104	603	9,600	SH	Call	SOLE		9,600	0	0
ZENTALIS PHARMACEUTICALS INC	COM	98943L107	16,067	191,140	SH		SOLE		191,140	0	0
ZOGENIX INC	COM NEW	98978L204	9,594	590,400	SH	Call	SOLE		590,400	0	0