Ikarian Capital 13F-HR Quarterly holdings report by institutional manager

The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

OMB APPROVAL

OMB Number:		3235-0006
Expires:	Oct 31, 2018
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COLUMN 1	COLUMN 2	COLUMN 3	COLUMN 4	COLUMN 5			COLUMN 6	COLUMN 7	COLUMN 8
			VALUE	SHRS OR	SH/	PUT/	INVESTMENT	OTHER	VOTING AUTHORITY
NAME OF ISSUER	TITLE OF CLASS	CUSIP	(x$1000)	PRN AMT	PRN	CALL	DISCRETION	MANAGER	SOLE	SHARED	NONE
2SEVENTY BIO INC	COMMON STOCK	901384107	1	99	SH		SOLE		99	0	0
AADI BIOSCIENCE INC	COM	00032Q104	3,536	208,368	SH		SOLE		208,368	0	0
ACADIA PHARMACEUTICALS INC	COM	004225108	46	1,882	SH		SOLE		1,882	0	0
ACLARIS THERAPEUTICS INC	COM	00461U105	208	12,124	SH		SOLE		12,124	0	0
ADICET BIO INC	COM	007002108	1,241	62,100	SH	Call	SOLE		62,100	0	0
ADICET BIO INC	COM	007002108	10,132	507,348	SH		SOLE		507,348	0	0
AGENUS INC	COM NEW	00847G705	267	108,933	SH		SOLE		108,933	0	0
AILERON THERAPEUTICS INC	COM	00887A105	1,487	2,902,086	SH		SOLE		2,902,086	0	0
AKEBIA THERAPEUTICS INC	COM	00972D105	860	1,200,000	SH	Put	SOLE		1,200,000	0	0
AKEBIA THERAPEUTICS INC	COM	00972D105	575	800,000	SH	Call	SOLE		800,000	0	0
ALDEYRA THERAPEUTICS INC	COM	01438T106	1,667	375,000	SH		SOLE		375,000	0	0
ALNYLAM PHARMACEUTICALS INC	COM	02043Q107	201	1,237	SH		SOLE		1,237	0	0
ALNYLAM PHARMACEUTICALS INC	COM	02043Q107	19,235	117,800	SH	Put	SOLE		117,800	0	0
ALNYLAM PHARMACEUTICALS INC	COM	02043Q107	22,077	135,200	SH	Call	SOLE		135,200	0	0
ALTAMIRA THERAPEUTICS LTD	SHS	G0360L100	351	320,010	SH		SOLE		320,010	0	0
AMGEN INC	COM	031162100	4,837	20,000	SH		SOLE		20,000	0	0
AMGEN INC	COM	031162100	24,182	100,000	SH	Call	SOLE		100,000	0	0
AMRYT PHARMA PLC	SPONSORED ADS	03217L106	70	37,248	SH		SOLE		37,248	0	0
AMYLYX PHARMACEUTICALS INC	COM	03237H101	5,097	396,654	SH		SOLE		396,654	0	0
AMYLYX PHARMACEUTICALS INC	COM	03237H101	3,213	250,000	SH	Call	SOLE		250,000	0	0
ANEBULO PHARMACEUTICALS INC	COM	034569103	1,225	181,199	SH		SOLE		181,199	0	0
APELLIS PHARMACEUTICALS INC	COM	03753U106	8,896	175,100	SH	Call	SOLE		175,100	0	0
APPLIED GENETIC TECHNOLOGIES	COM	03820J100	440	412,293	SH		SOLE		412,293	0	0
APTOSE BIOSCIENCES INC	COM NEW	03835T200	147	106,952	SH		SOLE		106,952	0	0
ARCUS BIOSCIENCES INC	COM	03969F109	4,734	150,000	SH	Call	SOLE		150,000	0	0
ASCENDIS PHARMA A/S	SPONSORED ADR	04351P101	1,028	8,763	SH		SOLE		8,763	0	0
ASLAN PHARMACEUTICALS LTD	ADS	04522R101	192	970,747	SH		SOLE		970,747	0	0
ASSEMBLY BIOSCIENCES INC	COM	045396108	468	227,076	SH		SOLE		227,076	0	0
ASTRIA THERAPEUTICS INC	COM	04635X102	619	92,223	SH		SOLE		92,223	0	0
ATHENEX INC	COM	04685N103	68	80,039	SH		SOLE		80,039	0	0
ATHIRA PHARMA INC	COM	04746L104	2,700	200,000	SH	Put	SOLE		200,000	0	0
ATHIRA PHARMA INC	COM	04746L104	10,587	784,200	SH	Call	SOLE		784,200	0	0
ATYR PHARMA INC	COM NEW	002120202	197	37,017	SH		SOLE		37,017	0	0
AURINIA PHARMACEUTICALS INC	COM	05156V102	1,077	87,071	SH		SOLE		87,071	0	0
AUTOLUS THERAPEUTICS PLC	SPON ADS	05280R100	1,552	372,217	SH		SOLE		372,217	0	0
AVALO THERAPEUTICS INC	COM	05338F108	554	764,271	SH		SOLE		764,271	0	0
AYALA PHARMACEUTICALS INC	COM	05465V108	2,819	708,383	SH		SOLE		708,383	0	0
BAUDAX BIO INC	COM NEW	07160F206	4	2,966	SH		SOLE		2,966	0	0
BCLS ACQUISITION CORP	COM CL A	G0904B105	762	77,274	SH		SOLE		77,274	0	0
BELLICUM PHARMACEUTICALS INC	COM NEW	079481404	1,131	523,348	SH		SOLE		523,348	0	0
BELLUS HEALTH INC NEW	COM NEW	07987C204	6,283	913,327	SH		SOLE		913,327	0	0
BICYCLE THERAPEUTICS PLC	SPONSORED ADS	088786108	11,617	264,700	SH	Call	SOLE		264,700	0	0
BICYCLE THERAPEUTICS PLC	SPONSORED ADS	088786108	4,677	106,600	SH	Put	SOLE		106,600	0	0
BICYCLE THERAPEUTICS PLC	SPONSORED ADS	088786108	21,009	478,784	SH		SOLE		478,784	0	0
BIOGEN INC	COM	09062X103	23,629	112,200	SH	Call	SOLE		112,200	0	0
BIOGEN INC	COM	09062X103	237	1,122	SH		SOLE		1,122	0	0
BIOHAVEN PHARMACTL HLDG CO L	COM	G11196105	7,114	60,000	SH		SOLE		60,000	0	0
BIOMARIN PHARMACEUTICAL INC	COM	09061G101	3,856	50,000	SH		SOLE		50,000	0	0
BIOMARIN PHARMACEUTICAL INC	COM	09061G101	24,192	313,800	SH	Call	SOLE		313,800	0	0
BIOXCEL THERAPEUTICS INC	COM	09075P105	113	5,428	SH		SOLE		5,428	0	0
BLACK DIAMOND THERAPEUTICS I	COM	09203E105	441	159,390	SH		SOLE		159,390	0	0
BLUEBIRD BIO INC	COM	09609G100	1	306	SH		SOLE		306	0	0
BLUEPRINT MEDICINES CORP	COM	09627Y109	4,088	64,000	SH	Call	SOLE		64,000	0	0
BRAINSTORM CELL THERAPEUTICS	COM NEW	10501E201	1,022	304,161	SH		SOLE		304,161	0	0
BRIGHT MINDS BIOSCIENCES INC	COM	10919W108	161	105,958	SH		SOLE		105,958	0	0
CABALETTA BIO INC	COM	12674W109	2,070	1,020,070	SH		SOLE		1,020,070	0	0
CABALETTA BIO INC	COM	12674W109	912	449,000	SH	Call	SOLE		449,000	0	0
CASI PHARMACEUTICALS INC	COM	14757U109	1,067	1,320,155	SH		SOLE		1,320,155	0	0
CATALYST BIOSCIENCES INC	COM NEW	14888D208	314	476,625	SH		SOLE		476,625	0	0
CELLDEX THERAPEUTICS INC NEW	COM NEW	15117B202	18,323	537,958	SH		SOLE		537,958	0	0
CELLDEX THERAPEUTICS INC NEW	COM NEW	15117B202	11,718	344,100	SH	Call	SOLE		344,100	0	0
CELLDEX THERAPEUTICS INC NEW	COM NEW	15117B202	20,282	595,500	SH	Put	SOLE		595,500	0	0
CHEMOMAB THERAPEUTICS LTD	SPONSORED ADS	16385C104	1,292	268,104	SH		SOLE		268,104	0	0
CHIMERIX INC	COM	16934W106	3,852	841,203	SH		SOLE		841,203	0	0
CLENE INC	COMMON STOCK	185634102	2,026	514,283	SH		SOLE		514,283	0	0
CLOVIS ONCOLOGY INC	COM	189464100	1,561	772,339	SH		SOLE		772,339	0	0
CODIAK BIOSCIENCES INC	COM	192010106	328	52,177	SH		SOLE		52,177	0	0
COMPASS THERAPEUTICS INC	COM	20454B104	100	74,171	SH		SOLE		74,171	0	0
CONNECT BIOPHARMA HLDGS LTD	ADS	207523101	2,047	677,859	SH		SOLE		677,859	0	0
CORBUS PHARMACEUTICALS HLDGS	COM	21833P103	530	997,627	SH		SOLE		997,627	0	0
CORVUS PHARMACEUTICALS INC	COM	221015100	837	510,126	SH		SOLE		510,126	0	0
CYCLACEL PHARMACEUTICALS INC	COM	23254L603	319	104,741	SH		SOLE		104,741	0	0
CYCLERION THERAPEUTICS INC	COM	23255M105	585	527,462	SH		SOLE		527,462	0	0
DBV TECHNOLOGIES S A	SPONSORED ADR	23306J101	1,047	316,939	SH		SOLE		316,939	0	0
DIAMEDICA THERAPEUTICS INC	COM NEW	25253X207	553	221,252	SH		SOLE		221,252	0	0
ELEDON PHARMACEUTICALS INC	COM	28617K101	1,429	362,537	SH		SOLE		362,537	0	0
ENVERIC BIOSCIENCES INC	COM NEW	29405E109	141	423,834	SH		SOLE		423,834	0	0
EYEPOINT PHARMACEUTICALS INC	COM NEW	30233G209	274	22,552	SH		SOLE		22,552	0	0
FATE THERAPEUTICS INC	COM	31189P102	374	9,640	SH		SOLE		9,640	0	0
FINCH THERAPEUTICS GROUP INC	COM	31773D101	1,662	330,523	SH		SOLE		330,523	0	0
GALAPAGOS NV	SPON ADR	36315X101	5,413	86,865	SH		SOLE		86,865	0	0
GAMIDA CELL LTD	SHS	M47364100	135	32,689	SH		SOLE		32,689	0	0
GEMINI THERAPEUTICS INC	COM	36870G105	615	443,096	SH		SOLE		443,096	0	0
GENOCEA BIOSCIENCES INC	COM NEW	372427401	259	206,336	SH		SOLE		206,336	0	0
GILEAD SCIENCES INC	COM	375558103	10,779	181,300	SH	Put	SOLE		181,300	0	0
GILEAD SCIENCES INC	COM	375558103	10,779	181,300	SH	Call	SOLE		181,300	0	0
GLOBAL BLOOD THERAPEUTICS IN	COM	37890U108	1,732	49,997	SH		SOLE		49,997	0	0
GOSSAMER BIO INC	COM	38341P102	1,836	211,600	SH	Call	SOLE		211,600	0	0
GOSSAMER BIO INC	COM	38341P102	6,730	775,315	SH		SOLE		775,315	0	0
GOSSAMER BIO INC	COM	38341P102	129	14,900	SH	Put	SOLE		14,900	0	0
HARPOON THERAPEUTICS INC	COM	41358P106	582	117,009	SH		SOLE		117,009	0	0
HEPION PHARMACEUTICALS INC	COM	426897104	751	582,137	SH		SOLE		582,137	0	0
HORIZON THERAPEUTICS PUB L	SHS	G46188101	16,633	158,100	SH	Call	SOLE		158,100	0	0
HORIZON THERAPEUTICS PUB L	SHS	G46188101	11,585	110,116	SH		SOLE		110,116	0	0
IGM BIOSCIENCES INC	COM	449585108	43	1,587	SH		SOLE		1,587	0	0
IMMATICS N.V	SHS	N44445109	6,243	781,388	SH		SOLE		781,388	0	0
IMMUNIC INC	COM	4525EP101	696	61,500	SH	Put	SOLE		61,500	0	0
IMMUNOPRECISE ANTIBODIES LTD	COM NEW	45257F200	399	77,650	SH		SOLE		77,650	0	0
INFLARX NV	COM	N44821101	639	349,468	SH		SOLE		349,468	0	0
INHIBRX INC	COM	45720L107	1,911	85,800	SH	Call	SOLE		85,800	0	0
INHIBRX INC	COM	45720L107	3,516	157,842	SH		SOLE		157,842	0	0
INTELLIA THERAPEUTICS INC	COM	45826J105	3,445	47,408	SH		SOLE		47,408	0	0
INTERCEPT PHARMACEUTICALS IN	COM	45845P108	572	35,149	SH		SOLE		35,149	0	0
INVENTIVA SA	ADS	46124U107	178	15,579	SH		SOLE		15,579	0	0
IVERIC BIO INC	COM	46583P102	825	49,099	SH		SOLE		49,099	0	0
KALVISTA PHARMACEUTICALS INC	COM	483497103	586	39,730	SH		SOLE		39,730	0	0
KARUNA THERAPEUTICS INC	COM	48576A100	6,340	50,000	SH		SOLE		50,000	0	0
KARYOPHARM THERAPEUTICS INC	COM	48576U106	6	830	SH		SOLE		830	0	0
KEZAR LIFE SCIENCES INC	COM	49372L100	18,001	1,083,116	SH		SOLE		1,083,116	0	0
KEZAR LIFE SCIENCES INC	COM	49372L100	4,666	280,800	SH	Call	SOLE		280,800	0	0
KINNATE BIOPHARMA INC	COM	49705R105	22	1,990	SH		SOLE		1,990	0	0
KODIAK SCIENCES INC	COM	50015M109	565	73,100	SH	Put	SOLE		73,100	0	0
KODIAK SCIENCES INC	COM	50015M109	199	25,700	SH	Call	SOLE		25,700	0	0
KODIAK SCIENCES INC	COM	50015M109	526	68,100	SH		SOLE		68,100	0	0
KYMERA THERAPEUTICS INC	COM	501575104	2,117	50,000	SH		SOLE		50,000	0	0
LARIMAR THERAPEUTICS INC	COM	517125100	209	51,606	SH		SOLE		51,606	0	0
LIQUIDIA CORPORATION	COM NEW	53635D202	1,751	243,904	SH		SOLE		243,904	0	0
LYRA THERAPEUTICS INC	COM	55234L105	1,698	422,338	SH		SOLE		422,338	0	0
MACROGENICS INC	COM	556099109	1,446	164,119	SH		SOLE		164,119	0	0
MAXCYTE INC	COM	57777K106	964	137,958	SH		SOLE		137,958	0	0
MEREO BIOPHARMA GROUP PLC	ADS	589492107	318	915,856	SH		SOLE		915,856	0	0
MERUS N V	COM	N5749R100	1,420	53,703	SH		SOLE		53,703	0	0
MILESTONE PHARMACEUTICALS IN	COM	59935V107	12,383	1,928,752	SH		SOLE		1,928,752	0	0
MIND MEDICINE MINDMED INC	COM SUB VTG	60255C109	118	105,958	SH		SOLE		105,958	0	0
MUSTANG BIO INC	COM	62818Q104	551	546,824	SH		SOLE		546,824	0	0
MYMD PHARMACEUTICALS INC	COM	62856X102	612	131,389	SH		SOLE		131,389	0	0
NEKTAR THERAPEUTICS	COM	640268108	722	133,900	SH	Call	SOLE		133,900	0	0
NEUROCRINE BIOSCIENCES INC	COM	64125C109	40,277	429,600	SH	Call	SOLE		429,600	0	0
NEUROSENSE THERAPEUTICS LTD	ORDINARY SHARES	M74240108	397	100,000	SH		SOLE		100,000	0	0
NEXTCURE INC	COM	65343E108	686	141,058	SH		SOLE		141,058	0	0
NOVAVAX INC	COM NEW	670002401	100	1,362	SH		SOLE		1,362	0	0
NUVATION BIO INC	COM CL A	67080N101	1,122	213,310	SH		SOLE		213,310	0	0
OCULAR THERAPEUTIX INC	COM	67576A100	147	29,644	SH		SOLE		29,644	0	0
OCUPHIRE PHARMA INC	COM	67577R102	401	124,021	SH		SOLE		124,021	0	0
ONCONOVA THERAPEUTICS INC	COM NEW	68232V801	35	18,975	SH		SOLE		18,975	0	0
ONCTERNAL THERAPEUTICS INC	COM	68236P107	292	210,182	SH		SOLE		210,182	0	0
ORCHARD THERAPEUTICS PLC	ADS	68570P101	110	155,606	SH		SOLE		155,606	0	0
OTONOMY INC	COM	68906L105	525	218,538	SH		SOLE		218,538	0	0
OVID THERAPEUTICS INC	COM	690469101	2,319	738,372	SH		SOLE		738,372	0	0
PANBELA THERAPEUTICS INC	COM	69833Q100	750	355,959	SH		SOLE		355,959	0	0
PARDES BIOSCIENCES INC	COM	69945Q105	2,338	323,934	SH		SOLE		323,934	0	0
PASSAGE BIO INC	COM	702712100	223	71,856	SH		SOLE		71,856	0	0
PDS BIOTECHNOLOGY CORP	COM	70465T107	22	3,672	SH		SOLE		3,672	0	0
PFIZER INC	COM	717081103	4,142	80,000	SH		SOLE		80,000	0	0
PHATHOM PHARMACEUTICALS INC	COM	71722W107	1,069	78,550	SH		SOLE		78,550	0	0
PLIANT THERAPEUTICS INC	COM	729139105	636	90,805	SH		SOLE		90,805	0	0
PMV PHARMACEUTICALS INC	COM	69353Y103	2,082	100,000	SH	Call	SOLE		100,000	0	0
PMV PHARMACEUTICALS INC	COM	69353Y103	2,082	100,000	SH	Put	SOLE		100,000	0	0
PROTAGONIST THERAPEUTICS INC	COM	74366E102	3,806	160,700	SH	Call	SOLE		160,700	0	0
PROTARA THERAPEUTICS INC	COM STK	74365U107	1,515	296,426	SH		SOLE		296,426	0	0
PUMA BIOTECHNOLOGY INC	COM	74587V107	144	49,843	SH		SOLE		49,843	0	0
QUANTUM SI INC	COM CL A	74765K105	736	157,363	SH		SOLE		157,363	0	0
REATA PHARMACEUTICALS INC	CL A	75615P103	502	15,300	SH	Call	SOLE		15,300	0	0
REATA PHARMACEUTICALS INC	CL A	75615P103	2,846	86,905	SH		SOLE		86,905	0	0
REATA PHARMACEUTICALS INC	CL A	75615P103	21,281	649,600	SH	Put	SOLE		649,600	0	0
REGULUS THERAPEUTICS INC	COM NEW	75915K200	384	1,289,130	SH		SOLE		1,289,130	0	0
RELMADA THERAPEUTICS INC	COM	75955J402	588	21,801	SH		SOLE		21,801	0	0
RENEO PHARMACEUTICALS INC	COM	75974E103	546	185,597	SH		SOLE		185,597	0	0
RENOVACOR INC	COM	75989E106	1,456	343,283	SH		SOLE		343,283	0	0
RIGEL PHARMACEUTICALS INC	COM NEW	766559603	6,390	2,137,128	SH		SOLE		2,137,128	0	0
SAGE THERAPEUTICS INC	COM	78667J108	8,275	250,000	SH	Call	SOLE		250,000	0	0
SAGE THERAPEUTICS INC	COM	78667J108	8,272	249,907	SH		SOLE		249,907	0	0
SATSUMA PHARMACEUTICALS INC	COM	80405P107	2,482	653,448	SH		SOLE		653,448	0	0
SAVARA INC	COM	805111101	2,126	1,622,552	SH		SOLE		1,622,552	0	0
SCPHARMACEUTICALS INC	COM	810648105	5,510	970,098	SH		SOLE		970,098	0	0
SEELOS THERAPEUTICS INC	COM	81577F109	215	257,883	SH		SOLE		257,883	0	0
SERES THERAPEUTICS INC	COM	81750R102	5,986	840,624	SH		SOLE		840,624	0	0
SIERRA ONCOLOGY INC	COM NEW	82640U404	6,983	217,915	SH		SOLE		217,915	0	0
SOLENO THERAPEUTICS INC	COM NEW	834203200	29	128,454	SH		SOLE		128,454	0	0
SOLID BIOSCIENCES INC	COM	83422E105	625	521,155	SH		SOLE		521,155	0	0
SPDR SER TR	S&P BIOTECH	78464A870	84,092	935,600	SH	Call	SOLE		935,600	0	0
STEALTH BIOTHERAPEUTICS CORP	SPONSORED ADS	85789A105	350	501,836	SH		SOLE		501,836	0	0
SYNAPTOGENIX INC	COM NEW	87167T201	1,186	153,226	SH		SOLE		153,226	0	0
SYNLOGIC INC	COM	87166L100	1,248	519,775	SH		SOLE		519,775	0	0
TANGO THERAPEUTICS INC	COM	87583X109	42	5,456	SH		SOLE		5,456	0	0
TEMPEST THERAPEUTICS INC	COM	87978U108	210	61,827	SH		SOLE		61,827	0	0
TENAX THERAPEUTICS INC	COM NEW	88032L209	596	735,097	SH		SOLE		735,097	0	0
TG THERAPEUTICS INC	COM	88322Q108	21	2,292	SH		SOLE		2,292	0	0
TRACON PHARMACEUTICALS INC	COM NEW	89237H209	7,477	2,843,232	SH		SOLE		2,843,232	0	0
TRICIDA INC	COM	89610F101	764	92,900	SH	Put	SOLE		92,900	0	0
UNITED THERAPEUTICS CORP DEL	COM	91307C102	17,942	100,000	SH	Call	SOLE		100,000	0	0
VALLON PHARMACEUTICALS INC	COM	92023M101	380	201,758	SH		SOLE		201,758	0	0
VASCULAR BIOGENICS LTD	COM	M96883109	1,404	830,747	SH		SOLE		830,747	0	0
VAXCYTE INC	COM	92243G108	7,630	315,991	SH		SOLE		315,991	0	0
VERASTEM INC	COM	92337C104	956	678,023	SH		SOLE		678,023	0	0
VERTEX PHARMACEUTICALS INC	COM	92532F100	6,524	25,000	SH		SOLE		25,000	0	0
VIKING THERAPEUTICS INC	COM	92686J106	1,596	532,429	SH		SOLE		532,429	0	0
VISTAGEN THERAPEUTICS INC	COM NEW	92840H202	633	511,186	SH		SOLE		511,186	0	0
VTV THERAPEUTICS INC	CL A	918385105	536	742,980	SH		SOLE		742,980	0	0
WAVE LIFE SCIENCES LTD	SHS	Y95308105	2,095	1,048,039	SH		SOLE		1,048,039	0	0
X4 PHARMACEUTICALS INC	COM	98420X103	2,402	1,372,022	SH		SOLE		1,372,022	0	0
XENON PHARMACEUTICALS INC	COM	98420N105	7,320	239,441	SH		SOLE		239,441	0	0
YUMANITY THERAPEUTICS INC	COM	98872L102	355	236,284	SH		SOLE		236,284	0	0
ZAI LAB LTD	ADR	98887Q104	376	81,843	SH		SOLE		81,843	0	0
ZAI LAB LTD	ADR	98887Q104	2,336	53,100	SH	Call	SOLE		53,100	0	0
ZENTALIS PHARMACEUTICALS INC	COM	98943L107	9,329	202,203	SH		SOLE		202,203	0	0