Ikarian Capital 13F-HR Quarterly holdings report by institutional manager

The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

OMB APPROVAL

OMB Number:		3235-0006
Expires:	Oct 31, 2018
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COLUMN 1	COLUMN 2	COLUMN 3	COLUMN 4	COLUMN 5			COLUMN 6	COLUMN 7	COLUMN 8
			VALUE	SHRS OR	SH/	PUT/	INVESTMENT	OTHER	VOTING AUTHORITY
NAME OF ISSUER	TITLE OF CLASS	CUSIP	(x$1000)	PRN AMT	PRN	CALL	DISCRETION	MANAGER	SOLE	SHARED	NONE
AADI BIOSCIENCE INC	COM	00032Q104	1,274	412,343	SH		SOLE		412,343	0	0
ADICET BIO INC	COM	007002108	2,091	143,214	SH		SOLE		143,214	0	0
AILERON THERAPEUTICS INC	COM	00887A105	752	2,892,316	SH		SOLE		2,892,316	0	0
ALDEYRA THERAPEUTICS INC	COM	01438T106	1,496	375,000	SH		SOLE		375,000	0	0
ALNYLAM PHARMACEUTICALS INC	COM	02043Q107	42,486	291,300	SH	Call	SOLE		291,300	0	0
ALNYLAM PHARMACEUTICALS INC	COM	02043Q107	8,931	61,237	SH		SOLE		61,237	0	0
ALNYLAM PHARMACEUTICALS INC	COM	02043Q107	5,820	39,900	SH	Put	SOLE		39,900	0	0
ALTAMIRA THERAPEUTICS LTD	SHS	G0360L100	36	75,000	SH		SOLE		75,000	0	0
ALTIMMUNE INC	COM NEW	02155H200	3,553	303,600	SH	Call	SOLE		303,600	0	0
ALTIMMUNE INC	COM NEW	02155H200	10,499	897,359	SH		SOLE		897,359	0	0
AMGEN INC	COM	031162100	24,330	100,000	SH	Call	SOLE		100,000	0	0
AMYLYX PHARMACEUTICALS INC	COM	03237H101	6,757	350,800	SH	Call	SOLE		350,800	0	0
AMYLYX PHARMACEUTICALS INC	COM	03237H101	4,750	246,554	SH		SOLE		246,554	0	0
ANEBULO PHARMACEUTICALS INC	COM	034569103	942	181,199	SH		SOLE		181,199	0	0
APELLIS PHARMACEUTICALS INC	COM	03753U106	5,572	123,200	SH	Call	SOLE		123,200	0	0
APELLIS PHARMACEUTICALS INC	COM	03753U106	1,894	41,900	SH		SOLE		41,900	0	0
ARCUS BIOSCIENCES INC	COM	03969F109	1,266	50,000	SH	Put	SOLE		50,000	0	0
ARCUS BIOSCIENCES INC	COM	03969F109	588	23,200	SH	Call	SOLE		23,200	0	0
ARDELYX INC	COM	039697107	991	1,680,552	SH		SOLE		1,680,552	0	0
ASLAN PHARMACEUTICALS LTD	ADS	04522R101	185	970,747	SH		SOLE		970,747	0	0
ASTRIA THERAPEUTICS INC	COM	04635X102	1,776	592,123	SH		SOLE		592,123	0	0
ATHIRA PHARMA INC	COM	04746L104	2,393	784,200	SH	Call	SOLE		784,200	0	0
ATHIRA PHARMA INC	COM	04746L104	609	199,500	SH	Put	SOLE		199,500	0	0
AUTOLUS THERAPEUTICS PLC	SPON ADS	05280R100	912	322,217	SH		SOLE		322,217	0	0
AXSOME THERAPEUTICS INC	COM	05464T104	19,151	500,000	SH	Put	SOLE		500,000	0	0
AXSOME THERAPEUTICS INC	COM	05464T104	13,404	350,000	SH	Call	SOLE		350,000	0	0
AYALA PHARMACEUTICALS INC	COM	05465V108	759	697,316	SH		SOLE		697,316	0	0
BAUDAX BIO INC	COM NEW	07160F206	3	2,966	SH		SOLE		2,966	0	0
BELLICUM PHARMACEUTICALS INC	COM NEW	079481404	617	523,348	SH		SOLE		523,348	0	0
BELLUS HEALTH INC NEW	COM NEW	07987C204	924	100,000	SH	Call	SOLE		100,000	0	0
BELLUS HEALTH INC NEW	COM NEW	07987C204	9,409	1,018,327	SH		SOLE		1,018,327	0	0
BIOGEN INC	COM	09062X103	22,880	112,200	SH	Call	SOLE		112,200	0	0
BIOGEN INC	COM	09062X103	228	1,122	SH		SOLE		1,122	0	0
BIOMARIN PHARMACEUTICAL INC	COM	09061G101	8,843	106,700	SH	Call	SOLE		106,700	0	0
BIOMARIN PHARMACEUTICAL INC	COM	09061G101	4,972	60,000	SH		SOLE		60,000	0	0
BLUEPRINT MEDICINES CORP	COM	09627Y109	3,232	64,000	SH	Call	SOLE		64,000	0	0
BRAINSTORM CELL THERAPEUTICS	COM NEW	10501E201	698	253,432	SH		SOLE		253,432	0	0
BRIDGEBIO PHARMA INC	COM	10806X102	1,817	200,000	SH	Call	SOLE		200,000	0	0
BRIGHT MINDS BIOSCIENCES INC	COM	10919W108	86	105,958	SH		SOLE		105,958	0	0
CABALETTA BIO INC	COM	12674W109	1,000	944,431	SH		SOLE		944,431	0	0
CASI PHARMACEUTICALS INC	COM NEW	14757U208	378	132,014	SH		SOLE		132,014	0	0
CELLDEX THERAPEUTICS INC NEW	COM NEW	15117B202	16,628	616,700	SH	Put	SOLE		616,700	0	0
CELLDEX THERAPEUTICS INC NEW	COM NEW	15117B202	14,504	537,958	SH		SOLE		537,958	0	0
CELLDEX THERAPEUTICS INC NEW	COM NEW	15117B202	13,656	506,500	SH	Call	SOLE		506,500	0	0
CHEMOMAB THERAPEUTICS LTD	SPONSORED ADS	16385C104	992	268,104	SH		SOLE		268,104	0	0
CHIMERIX INC	COM	16934W106	917	441,203	SH		SOLE		441,203	0	0
CHINOOK THERAPEUTICS INC	COM	16961L106	0	332,295	SH		SOLE		332,295	0	0
CLENE INC	COMMON STOCK	185634102	177	70,000	SH		SOLE		70,000	0	0
CLOVIS ONCOLOGY INC	COM	189464100	761	422,339	SH		SOLE		422,339	0	0
COGENT BIOSCIENCES INC	COM	19240Q201	2,256	250,000	SH		SOLE		250,000	0	0
CONNECT BIOPHARMA HLDGS LTD	ADS	207523101	591	677,859	SH		SOLE		677,859	0	0
CONTRAFECT CORP	COM NEW	212326300	615	200,000	SH	Put	SOLE		200,000	0	0
CORBUS PHARMACEUTICALS HLDGS	COM	21833P103	217	862,527	SH		SOLE		862,527	0	0
CYCLACEL PHARMACEUTICALS INC	COM	23254L603	113	104,741	SH		SOLE		104,741	0	0
DBV TECHNOLOGIES S A	SPONSORED ADR	23306J101	1,401	316,939	SH		SOLE		316,939	0	0
ELEDON PHARMACEUTICALS INC	COM	28617K101	884	362,537	SH		SOLE		362,537	0	0
ENVERIC BIOSCIENCES INC	COM NEW	29405E109	48	223,834	SH		SOLE		223,834	0	0
ESPERION THERAPEUTICS INC NE	COM	29664W105	13,067	2,054,602	SH		SOLE		2,054,602	0	0
EVOLUS INC	COM	30052C107	529	45,516	SH		SOLE		45,516	0	0
FINCH THERAPEUTICS GROUP INC	COM	31773D101	938	330,523	SH		SOLE		330,523	0	0
FULCRUM THERAPEUTICS INC	COM	359616109	893	182,200	SH	Call	SOLE		182,200	0	0
GALAPAGOS NV	SPON ADR	36315X101	4,830	86,865	SH		SOLE		86,865	0	0
GEMINI THERAPEUTICS INC	COM	36870G105	749	443,096	SH		SOLE		443,096	0	0
GOSSAMER BIO INC	COM	38341P102	8,373	1,000,387	SH		SOLE		1,000,387	0	0
GOSSAMER BIO INC	COM	38341P102	2,800	334,500	SH	Call	SOLE		334,500	0	0
HARMONY BIOSCIENCES HLDGS IN	COM	413197104	4,196	86,035	SH		SOLE		86,035	0	0
HEPION PHARMACEUTICALS INC	COM	426897104	235	410,189	SH		SOLE		410,189	0	0
HORIZON THERAPEUTICS PUB L	SHS	G46188101	12,771	160,116	SH		SOLE		160,116	0	0
HORIZON THERAPEUTICS PUB L	SHS	G46188101	7,976	100,000	SH	Call	SOLE		100,000	0	0
IMMATICS N.V	SHS	N44445109	1,369	157,190	SH		SOLE		157,190	0	0
IMMUNIC INC	COM	4525EP101	214	61,500	SH		SOLE		61,500	0	0
IMMUNIC INC	COM	4525EP101	213	61,500	SH	Put	SOLE		61,500	0	0
IMMUNOPRECISE ANTIBODIES LTD	COM NEW	45257F200	237	61,433	SH		SOLE		61,433	0	0
INHIBRX INC	COM	45720L107	561	49,372	SH		SOLE		49,372	0	0
INSMED INC	COM PAR $.01	457669307	2,465	125,000	SH		SOLE		125,000	0	0
INTERCEPT PHARMACEUTICALS IN	COM	45845P108	1,449	105,000	SH		SOLE		105,000	0	0
INTERCEPT PHARMACEUTICALS IN	COM	45845P108	4,832	350,000	SH	Call	SOLE		350,000	0	0
INVENTIVA SA	ADS	46124U107	93	15,579	SH		SOLE		15,579	0	0
ITEOS THERAPEUTICS INC	COM	46565G104	2,061	100,000	SH	Call	SOLE		100,000	0	0
IVERIC BIO INC	COM	46583P102	2,351	244,400	SH	Call	SOLE		244,400	0	0
IVERIC BIO INC	COM	46583P102	473	49,099	SH		SOLE		49,099	0	0
KARUNA THERAPEUTICS INC	COM	48576A100	12,652	100,000	SH	Put	SOLE		100,000	0	0
KARUNA THERAPEUTICS INC	COM	48576A100	12,651	100,000	SH		SOLE		100,000	0	0
KEZAR LIFE SCIENCES INC	COM	49372L100	8,894	1,075,300	SH	Call	SOLE		1,075,300	0	0
KEZAR LIFE SCIENCES INC	COM	49372L100	11,645	1,408,116	SH		SOLE		1,408,116	0	0
KRANESHARES TR	CSI CHI INTERNET	500767306	3,277	100,000	SH		SOLE		100,000	0	0
LANTHEUS HLDGS INC	COM	516544103	6,602	100,000	SH	Call	SOLE		100,000	0	0
LARIMAR THERAPEUTICS INC	COM	517125100	100	51,606	SH		SOLE		51,606	0	0
LYRA THERAPEUTICS INC	COM	55234L105	1,963	347,338	SH		SOLE		347,338	0	0
MEREO BIOPHARMA GROUP PLC	ADS	589492107	199	615,856	SH		SOLE		615,856	0	0
MERUS N V	COM	N5749R100	1,216	53,703	SH		SOLE		53,703	0	0
MILESTONE PHARMACEUTICALS IN	COM	59935V107	1,261	212,400	SH	Call	SOLE		212,400	0	0
MILESTONE PHARMACEUTICALS IN	COM	59935V107	8,194	1,379,422	SH		SOLE		1,379,422	0	0
MIND MEDICINE MINDMED INC	COM SUB VTG	60255C109	68	105,958	SH		SOLE		105,958	0	0
MUSTANG BIO INC	COM	62818Q104	145	246,824	SH		SOLE		246,824	0	0
MYMD PHARMACEUTICALS INC	COM	62856X102	176	81,089	SH		SOLE		81,089	0	0
NEUROCRINE BIOSCIENCES INC	COM	64125C109	3,763	38,600	SH		SOLE		38,600	0	0
NEXTCURE INC	COM	65343E108	336	71,435	SH		SOLE		71,435	0	0
OTONOMY INC	COM	68906L105	0	180	SH		SOLE		180	0	0
OVID THERAPEUTICS INC	COM	690469101	59	26,831	SH		SOLE		26,831	0	0
PARDES BIOSCIENCES INC	COM	69945Q105	687	223,934	SH		SOLE		223,934	0	0
PFIZER INC	COM	717081103	4,194	80,000	SH		SOLE		80,000	0	0
PRAXIS PRECISION MEDICINES I	COM	74006W108	263	107,200	SH	Call	SOLE		107,200	0	0
PROTARA THERAPEUTICS INC	COM STK	74365U107	756	257,853	SH		SOLE		257,853	0	0
REATA PHARMACEUTICALS INC	CL A	75615P103	632	20,805	SH		SOLE		20,805	0	0
REATA PHARMACEUTICALS INC	CL A	75615P103	4,923	162,000	SH	Call	SOLE		162,000	0	0
REGULUS THERAPEUTICS INC	COM	75915K309	217	105,341	SH		SOLE		105,341	0	0
RELMADA THERAPEUTICS INC	COM	75955J402	5,698	300,000	SH	Call	SOLE		300,000	0	0
RELMADA THERAPEUTICS INC	COM	75955J402	5,362	282,300	SH	Put	SOLE		282,300	0	0
RENEO PHARMACEUTICALS INC	COM	75974E103	491	185,597	SH		SOLE		185,597	0	0
RENOVACOR INC	COM	75989E106	595	293,283	SH		SOLE		293,283	0	0
RIGEL PHARMACEUTICALS INC	COM NEW	766559603	794	702,773	SH		SOLE		702,773	0	0
SAGE THERAPEUTICS INC	COM	78667J108	8,075	250,000	SH	Call	SOLE		250,000	0	0
SAREPTA THERAPEUTICS INC	COM	803607100	7,495	100,000	SH	Call	SOLE		100,000	0	0
SAREPTA THERAPEUTICS INC	COM	803607100	1,874	25,000	SH		SOLE		25,000	0	0
SATSUMA PHARMACEUTICALS INC	COM	80405P107	2,704	653,448	SH		SOLE		653,448	0	0
SCPHARMACEUTICALS INC	COM	810648105	4,261	884,008	SH		SOLE		884,008	0	0
SERES THERAPEUTICS INC	COM	81750R102	1,854	540,624	SH		SOLE		540,624	0	0
SPDR SER TR	S&P BIOTECH	78464A870	25,994	350,000	SH	Put	SOLE		350,000	0	0
STEALTH BIOTHERAPEUTICS CORP	SPONSORED ADS	85789A105	127	501,836	SH		SOLE		501,836	0	0
SYNAPTOGENIX INC	COM NEW	87167T201	614	121,191	SH		SOLE		121,191	0	0
SYNLOGIC INC	COM	87166L100	545	474,360	SH		SOLE		474,360	0	0
TEMPEST THERAPEUTICS INC	COM	87978U108	132	61,827	SH		SOLE		61,827	0	0
TERNS PHARMACEUTICALS INC	COM	880881107	1,736	700,000	SH		SOLE		700,000	0	0
TRACON PHARMACEUTICALS INC	COM NEW	89237H209	5,577	2,788,853	SH		SOLE		2,788,853	0	0
TRICIDA INC	COM	89610F101	899	92,900	SH	Put	SOLE		92,900	0	0
UNITED THERAPEUTICS CORP DEL	COM	91307C102	9,426	40,000	SH		SOLE		40,000	0	0
VASCULAR BIOGENICS LTD	COM	M96883109	1,337	830,007	SH		SOLE		830,007	0	0
VAXCYTE INC	COM	92243G108	4,918	225,991	SH		SOLE		225,991	0	0
VERASTEM INC	COM	92337C104	265	228,023	SH		SOLE		228,023	0	0
VERONA PHARMA PLC	SPONSORED ADS	925050106	200	300,000	SH		SOLE		300,000	0	0
VERTEX PHARMACEUTICALS INC	COM	92532F100	11,271	40,000	SH		SOLE		40,000	0	0
VIKING THERAPEUTICS INC	COM	92686J106	2,414	835,275	SH		SOLE		835,275	0	0
VIRIDIAN THERAPEUTICS INC	COM	92790C104	3,472	300,000	SH	Call	SOLE		300,000	0	0
WAVE LIFE SCIENCES LTD	SHS	Y95308105	318	98,039	SH		SOLE		98,039	0	0
X4 PHARMACEUTICALS INC	COM	98420X103	1,621	1,679,748	SH		SOLE		1,679,748	0	0
XENON PHARMACEUTICALS INC	COM	98420N105	7,283	239,441	SH		SOLE		239,441	0	0
YUMANITY THERAPEUTICS INC	COM	98872L102	190	104,392	SH		SOLE		104,392	0	0
ZAI LAB LTD	ADR	98887Q104	278	81,843	SH		SOLE		81,843	0	0