Ikarian Capital 13F-HR Quarterly holdings report by institutional manager

The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

OMB APPROVAL

OMB Number:		3235-0006
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COLUMN 1	COLUMN 2	COLUMN 3	COLUMN 4	COLUMN 5			COLUMN 6	COLUMN 7	COLUMN 8
			VALUE	SHRS OR	SH/	PUT/	INVESTMENT	OTHER	VOTING AUTHORITY
NAME OF ISSUER	TITLE OF CLASS	CUSIP	(x$1000)	PRN AMT	PRN	CALL	DISCRETION	MANAGER	SOLE	SHARED	NONE
ACADIA PHARMACEUTICALS INC	COM	004225108	1,129,200	60,000	SH		SOLE		60,000	0	0
ACHIEVE LIFE SCIENCES INC	COM	004468500	989,535	174,714	SH		SOLE		174,714	0	0
ACLARIS THERAPEUTICS INC	COM	00461U105	5,921,880	732,000	SH	Put	SOLE		732,000	0	0
ACLARIS THERAPEUTICS INC	COM	00461U105	4,767,437	589,300	SH	Call	SOLE		589,300	0	0
ACLARIS THERAPEUTICS INC	COM	00461U105	2,428,319	300,163	SH		SOLE		300,163	0	0
ACUMEN PHARMACEUTICALS INC	COM	00509G209	1,035,077	254,945	SH		SOLE		254,945	0	0
AEROVATE THERAPEUTICS INC	COM	008064107	3,936,094	195,146	SH		SOLE		195,146	0	0
AKERO THERAPEUTICS INC	COM	00973Y108	1,913,000	50,000	SH		SOLE		50,000	0	0
ALTIMMUNE INC	COM NEW	02155H200	4,545,784	1,077,200	SH	Put	SOLE		1,077,200	0	0
ALTIMMUNE INC	COM NEW	02155H200	3,792,092	898,600	SH	Call	SOLE		898,600	0	0
ALTIMMUNE INC	COM NEW	02155H200	2,858,206	677,300	SH		SOLE		677,300	0	0
AMYLYX PHARMACEUTICALS INC	COM	03237H101	293,400	10,000	SH		SOLE		10,000	0	0
AMYLYX PHARMACEUTICALS INC	COM	03237H101	4,401,000	150,000	SH	Call	SOLE		150,000	0	0
ANEBULO PHARMACEUTICALS INC	COM	034569103	462,360	156,203	SH		SOLE		156,203	0	0
APELLIS PHARMACEUTICALS INC	COM	03753U106	6,595,999	100,000	SH		SOLE		100,000	0	0
ARCUS BIOSCIENCES INC	COM	03969F109	4,195,200	230,000	SH		SOLE		230,000	0	0
ARDELYX INC	COM	039697107	2,772,572	578,825	SH		SOLE		578,825	0	0
ARK ETF TR	INNOVATION ETF	00214Q104	182,297	4,519	SH		SOLE		4,519	0	0
ARK ETF TR	GENOMIC REV ETF	00214Q302	1,397,112	46,462	SH		SOLE		46,462	0	0
ASLAN PHARMACEUTICALS LTD	SPON ADS NEW	04522R200	475,856	164,088	SH		SOLE		164,088	0	0
ASTRIA THERAPEUTICS INC	COM	04635X102	11,562,887	869,390	SH		SOLE		869,390	0	0
AUTOLUS THERAPEUTICS PLC	SPON ADS	05280R100	478,559	260,087	SH		SOLE		260,087	0	0
AXSOME THERAPEUTICS INC	COM	05464T104	9,252,000	150,000	SH	Call	SOLE		150,000	0	0
AXSOME THERAPEUTICS INC	COM	05464T104	9,252,000	150,000	SH	Put	SOLE		150,000	0	0
BELLICUM PHARMACEUTICALS INC	COM NEW	079481404	147,873	448,101	SH		SOLE		448,101	0	0
BELLUS HEALTH INC NEW	COM NEW	07987C204	6,374,405	885,334	SH		SOLE		885,334	0	0
BICYCLE THERAPEUTICS PLC	SPONSORED ADS	088786108	4,254,000	200,000	SH	Call	SOLE		200,000	0	0
BICYCLE THERAPEUTICS PLC	SPONSORED ADS	088786108	4,405,273	207,112	SH		SOLE		207,112	0	0
BIOGEN INC	COM	09062X103	267,465	962	SH		SOLE		962	0	0
BIOHAVEN LTD	COM	G1110E107	617,432	45,200	SH	Call	SOLE		45,200	0	0
BIOHAVEN LTD	COM	G1110E107	5,495,774	402,326	SH		SOLE		402,326	0	0
BIOMARIN PHARMACEUTICAL INC	COM	09061G101	4,862,000	50,000	SH		SOLE		50,000	0	0
BIOMEA FUSION INC	COM	09077A106	9,023,910	291,000	SH	Call	SOLE		291,000	0	0
BIOMEA FUSION INC	COM	09077A106	1,240,400	40,000	SH	Put	SOLE		40,000	0	0
BIOMEA FUSION INC	COM	09077A106	6,542,334	210,975	SH		SOLE		210,975	0	0
BIOVIE INC	CL A NEW	09074F207	2,816,332	348,556	SH		SOLE		348,556	0	0
BIOXCEL THERAPEUTICS INC	COM	09075P105	1,328,592	71,200	SH	Call	SOLE		71,200	0	0
BIOXCEL THERAPEUTICS INC	COM	09075P105	2,482,041	133,014	SH		SOLE		133,014	0	0
BLUEBIRD BIO INC	COM	09609G100	1,312,157	412,628	SH		SOLE		412,628	0	0
BRAINSTORM CELL THERAPEUTICS	COM NEW	10501E201	626,786	189,935	SH		SOLE		189,935	0	0
BRIDGEBIO PHARMA INC	COM	10806X102	9,112,368	549,600	SH	Call	SOLE		549,600	0	0
BRIDGEBIO PHARMA INC	COM	10806X102	9,859,894	594,686	SH		SOLE		594,686	0	0
CELLDEX THERAPEUTICS INC NEW	COM NEW	15117B202	3,815,932	106,057	SH		SOLE		106,057	0	0
CELLDEX THERAPEUTICS INC NEW	COM NEW	15117B202	3,957,800	110,000	SH	Put	SOLE		110,000	0	0
CHEMOMAB THERAPEUTICS LTD	SPONSORED ADS	16385C104	342,091	236,709	SH		SOLE		236,709	0	0
CHINOOK THERAPEUTICS INC	COM	16961L106	6,562,191	283,464	SH		SOLE		283,464	0	0
COGENT BIOSCIENCES INC	COM	19240Q201	677,246	62,766	SH		SOLE		62,766	0	0
CONNECT BIOPHARMA HLDGS LTD	ADS	207523101	219,479	219,501	SH		SOLE		219,501	0	0
CORBUS PHARMACEUTICALS HLDGS	COM NEW	21833P301	1,397,730	192,260	SH		SOLE		192,260	0	0
CYCLACEL PHARMACEUTICALS INC	COM	23254L603	10,999	275,000	SH		SOLE		275,000	0	0
CYTOKINETICS INC	COM NEW	23282W605	1,958,886	55,666	SH		SOLE		55,666	0	0
DECIPHERA PHARMACEUTICALS IN	COM	24344T101	2,696,179	174,510	SH		SOLE		174,510	0	0
DELCATH SYS INC	COM NEW	24661P807	1,078,601	360,569	SH		SOLE		360,569	0	0
ELEDON PHARMACEUTICALS INC	COM	28617K101	523,518	221,830	SH		SOLE		221,830	0	0
ERYTECH PHARMA	SPONSORED ADR	29604W108	252,111	248,426	SH		SOLE		248,426	0	0
ESPERION THERAPEUTICS INC NE	COM	29664W105	2,155,411	1,355,605	SH		SOLE		1,355,605	0	0
FINCH THERAPEUTICS GROUP INC	COM	31773D101	93,359	237,553	SH		SOLE		237,553	0	0
GENFIT S A	ADS	372279109	131,511	32,786	SH		SOLE		32,786	0	0
GOSSAMER BIO INC	COM	38341P102	7,686	6,100	SH		SOLE		6,100	0	0
IMMATICS N.V	SHS	N44445109	526,266	179,552	SH		SOLE		179,552	0	0
IMMUNIC INC	COM	4525EP101	968,500	650,000	SH		SOLE		650,000	0	0
IMMUNOGEN INC	COM	45253H101	409,344	106,600	SH	Call	SOLE		106,600	0	0
IMMUNOVANT INC	COM	45258J102	2,486,253	160,300	SH	Call	SOLE		160,300	0	0
IMMUNOVANT INC	COM	45258J102	12,010,913	774,398	SH		SOLE		774,398	0	0
INSMED INC	COM PAR $.01	457669307	8,269,250	485,000	SH		SOLE		485,000	0	0
INSMED INC	COM PAR $.01	457669307	3,410,000	200,000	SH	Call	SOLE		200,000	0	0
INTERCEPT PHARMACEUTICALS IN	COM	45845P108	1,144,236	85,200	SH		SOLE		85,200	0	0
INTRA-CELLULAR THERAPIES INC	COM	46116X101	20,577,000	380,000	SH	Call	SOLE		380,000	0	0
INVENTIVA SA	ADS	46124U107	999,202	292,599	SH		SOLE		292,599	0	0
IVERIC BIO INC	COM	46583P102	5,194,967	213,521	SH		SOLE		213,521	0	0
JASPER THERAPEUTICS INC	COM	471871103	2,038,579	1,126,287	SH		SOLE		1,126,287	0	0
KALVISTA PHARMACEUTICALS INC	COM	483497103	1,100,400	140,000	SH		SOLE		140,000	0	0
KARYOPHARM THERAPEUTICS INC	COM	48576U106	1,167,000	300,000	SH		SOLE		300,000	0	0
KEZAR LIFE SCIENCES INC	COM	49372L100	2,634,195	841,596	SH		SOLE		841,596	0	0
KODIAK SCIENCES INC	COM	50015M109	1,007,668	162,527	SH		SOLE		162,527	0	0
KRYSTAL BIOTECH INC	COM	501147102	824,618	10,300	SH	Put	SOLE		10,300	0	0
LYRA THERAPEUTICS INC	COM	55234L105	711,427	343,685	SH		SOLE		343,685	0	0
MACROGENICS INC	COM	556099109	1,792,500	250,000	SH		SOLE		250,000	0	0
MADRIGAL PHARMACEUTICALS INC	COM	558868105	18,170	75	SH		SOLE		75	0	0
MERCK & CO INC	COM	58933Y105	10,639,000	100,000	SH		SOLE		100,000	0	0
MERUS N V	COM	N5749R100	3,839,161	208,650	SH		SOLE		208,650	0	0
MILESTONE PHARMACEUTICALS IN	COM	59935V107	1,814,039	460,416	SH		SOLE		460,416	0	0
MIRATI THERAPEUTICS INC	COM	60468T105	1,230,658	33,100	SH		SOLE		33,100	0	0
MORPHIC HLDG INC	COM	61775R105	1,726,660	45,873	SH		SOLE		45,873	0	0
MORPHIC HLDG INC	COM	61775R105	8,032,376	213,400	SH	Call	SOLE		213,400	0	0
OCULAR THERAPEUTIX INC	COM	67576A100	1,054,000	200,000	SH		SOLE		200,000	0	0
POINT BIOPHARMA GLOBAL INC	COM	730541109	1,014,639	139,565	SH		SOLE		139,565	0	0
PROMETHEUS BIOSCIENCES INC	COM	74349U108	13,514,378	125,926	SH		SOLE		125,926	0	0
PROQR THRAPEUTICS N V	SHS EURO	N71542109	1,006,691	472,625	SH		SOLE		472,625	0	0
PROTAGONIST THERAPEUTICS INC	COM	74366E102	4,862,200	211,400	SH	Put	SOLE		211,400	0	0
PROTAGONIST THERAPEUTICS INC	COM	74366E102	4,862,200	211,400	SH	Call	SOLE		211,400	0	0
PROTARA THERAPEUTICS INC	COM STK	74365U107	584,859	188,664	SH		SOLE		188,664	0	0
PTC THERAPEUTICS INC	COM	69366J200	474,712	9,800	SH	Call	SOLE		9,800	0	0
REATA PHARMACEUTICALS INC	CL A	75615P103	9,092,000	100,000	SH	Call	SOLE		100,000	0	0
REATA PHARMACEUTICALS INC	CL A	75615P103	7,324,879	80,564	SH		SOLE		80,564	0	0
RELMADA THERAPEUTICS INC	COM	75955J402	148,010	65,491	SH		SOLE		65,491	0	0
RENEO PHARMACEUTICALS INC	COM	75974E103	931,798	155,819	SH		SOLE		155,819	0	0
ROCKET PHARMACEUTICALS INC	*W EXP 09/02/202	77313F114	59,985	367,112	SH		SOLE		367,112	0	0
ROIVANT SCIENCES LTD	SHS	G76279101	4,243,500	575,000	SH		SOLE		575,000	0	0
SAGE THERAPEUTICS INC	COM	78667J108	747,098	17,805	SH		SOLE		17,805	0	0
SAREPTA THERAPEUTICS INC	COM	803607100	28,310,282	205,400	SH	Call	SOLE		205,400	0	0
SAREPTA THERAPEUTICS INC	COM	803607100	37,393,279	271,300	SH	Put	SOLE		271,300	0	0
SAREPTA THERAPEUTICS INC	COM	803607100	1,147,297	8,324	SH		SOLE		8,324	0	0
SATSUMA PHARMACEUTICALS INC	COM	80405P107	95,037	136,059	SH		SOLE		136,059	0	0
SELECT SECTOR SPDR TR	SBI HEALTHCARE	81369Y209	3,556,137	27,469	SH		SOLE		27,469	0	0
SPDR SER TR	S&P BIOTECH	78464A870	7,621,000	100,000	SH	Put	SOLE		100,000	0	0
SPECTRUM PHARMACEUTICALS INC	COM	84763A108	132,735	176,980	SH		SOLE		176,980	0	0
SYNLOGIC INC	COM	87166L100	193,871	306,757	SH		SOLE		306,757	0	0
TERNS PHARMACEUTICALS INC	COM	880881107	8,540,677	721,341	SH		SOLE		721,341	0	0
TRACON PHARMACEUTICALS INC	COM NEW	89237H209	5,226,851	2,765,530	SH		SOLE		2,765,530	0	0
TYRA BIOSCIENCES INC	COM	90240B106	774,092	48,170	SH		SOLE		48,170	0	0
VAXCYTE INC	COM	92243G108	8,433,000	225,000	SH		SOLE		225,000	0	0
VENTYX BIOSCIENCES INC	COM	92332V107	2,177,501	65,000	SH		SOLE		65,000	0	0
VERONA PHARMA PLC	SPONSORED ADS	925050106	4,591,834	228,677	SH		SOLE		228,677	0	0
VIKING THERAPEUTICS INC	COM	92686J106	718,548	43,156	SH		SOLE		43,156	0	0
X4 PHARMACEUTICALS INC	COM	98420X103	303,745	349,133	SH		SOLE		349,133	0	0
XENON PHARMACEUTICALS INC	COM	98420N105	5,743,793	160,486	SH		SOLE		160,486	0	0