The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||||||
| UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| 4D MOLECULAR THERAPEUTICS IN | COM | 35104E100 | 421 | 39 | SH | SOLE | 39 | 0 | 0 | ||
| ABEONA THERAPEUTICS INC | COM NEW | 00289Y206 | 3,688,308 | 583,593 | SH | SOLE | 583,593 | 0 | 0 | ||
| ACELYRIN INC | COM | 00445A100 | 3,337,975 | 677,074 | SH | SOLE | 677,074 | 0 | 0 | ||
| ACHILLES THERAPEUTICS PLC | SPONSORED ADS | 00449L102 | 1,472,045 | 1,443,181 | SH | SOLE | 1,443,181 | 0 | 0 | ||
| ACUMEN PHARMACEUTICALS INC | COM | 00509G209 | 660,759 | 266,435 | SH | SOLE | 266,435 | 0 | 0 | ||
| AEON BIOPHARMA INC | CL A | 00791X100 | 270,876 | 257,977 | SH | SOLE | 257,977 | 0 | 0 | ||
| AEROVATE THERAPEUTICS INC | COM | 008064107 | 769,046 | 367,965 | SH | SOLE | 367,965 | 0 | 0 | ||
| AKERO THERAPEUTICS INC | COM | 00973Y108 | 5,706,441 | 198,900 | SH | Put | SOLE | 198,900 | 0 | 0 | |
| ALLAKOS INC | COM | 01671P100 | 635,352 | 972,675 | SH | SOLE | 972,675 | 0 | 0 | ||
| ALNYLAM PHARMACEUTICALS INC | COM | 02043Q107 | 2,404,038 | 8,741 | SH | SOLE | 8,741 | 0 | 0 | ||
| ALTO NEUROSCIENCE INC | COM SHS | 02157Q109 | 5,148,000 | 450,000 | SH | Put | SOLE | 450,000 | 0 | 0 | |
| ALTO NEUROSCIENCE INC | COM SHS | 02157Q109 | 4,930,640 | 431,000 | SH | Call | SOLE | 431,000 | 0 | 0 | |
| AMGEN INC | COM | 031162100 | 47,042,660 | 146,000 | SH | Call | SOLE | 146,000 | 0 | 0 | |
| AMGEN INC | COM | 031162100 | 4,285,394 | 13,300 | SH | SOLE | 13,300 | 0 | 0 | ||
| AMYLYX PHARMACEUTICALS INC | COM | 03237H101 | 889,546 | 274,551 | SH | SOLE | 274,551 | 0 | 0 | ||
| ANAPTYSBIO INC | COM | 032724106 | 13,544,050 | 404,300 | SH | Put | SOLE | 404,300 | 0 | 0 | |
| ANAPTYSBIO INC | COM | 032724106 | 11,725,000 | 350,000 | SH | Call | SOLE | 350,000 | 0 | 0 | |
| ANEBULO PHARMACEUTICALS INC | COM | 034569103 | 304,675 | 157,862 | SH | SOLE | 157,862 | 0 | 0 | ||
| APELLIS PHARMACEUTICALS INC | COM | 03753U106 | 5,768,000 | 200,000 | SH | Put | SOLE | 200,000 | 0 | 0 | |
| APELLIS PHARMACEUTICALS INC | COM | 03753U106 | 4,326,000 | 150,000 | SH | Call | SOLE | 150,000 | 0 | 0 | |
| APOGEE THERAPEUTICS INC | COM | 03770N101 | 293,700 | 5,000 | SH | Call | SOLE | 5,000 | 0 | 0 | |
| ARCUS BIOSCIENCES INC | COM | 03969F109 | 1,738,473 | 113,700 | SH | Call | SOLE | 113,700 | 0 | 0 | |
| ARCUS BIOSCIENCES INC | COM | 03969F109 | 11,375,760 | 744,000 | SH | SOLE | 744,000 | 0 | 0 | ||
| AVALO THERAPEUTICS INC | COM NEW | 05338F306 | 9,218,411 | 970,359 | SH | SOLE | 970,359 | 0 | 0 | ||
| BEIGENE LTD | SPONSORED ADR | 07725L102 | 6,690,398 | 29,800 | SH | Call | SOLE | 29,800 | 0 | 0 | |
| BEIGENE LTD | SPONSORED ADR | 07725L102 | 1,641,345 | 88,167 | SH | SOLE | 88,167 | 0 | 0 | ||
| BIOHAVEN LTD | COM | G1110E107 | 16,270,232 | 325,600 | SH | Put | SOLE | 325,600 | 0 | 0 | |
| BIOMEA FUSION INC | COM | 09077A106 | 535,300 | 53,000 | SH | Put | SOLE | 53,000 | 0 | 0 | |
| BIOMX INC | COM NEW | 09090D301 | 910,860 | 893,000 | SH | SOLE | 893,000 | 0 | 0 | ||
| BLACK DIAMOND THERAPEUTICS I | COM | 09203E105 | 4,132,500 | 950,000 | SH | Put | SOLE | 950,000 | 0 | 0 | |
| BLACK DIAMOND THERAPEUTICS I | COM | 09203E105 | 3,045,000 | 700,000 | SH | Call | SOLE | 700,000 | 0 | 0 | |
| BLUEPRINT MEDICINES CORP | COM | 09627Y109 | 7,862,501 | 85,000 | SH | SOLE | 85,000 | 0 | 0 | ||
| BRIDGEBIO PHARMA INC | COM | 10806X102 | 7,271,706 | 285,613 | SH | SOLE | 285,613 | 0 | 0 | ||
| CAPRICOR THERAPEUTICS INC | COM NEW | 14070B309 | 4,563,000 | 300,000 | SH | Put | SOLE | 300,000 | 0 | 0 | |
| CAPRICOR THERAPEUTICS INC | COM NEW | 14070B309 | 4,563,000 | 300,000 | SH | Call | SOLE | 300,000 | 0 | 0 | |
| CAPRICOR THERAPEUTICS INC | COM NEW | 14070B309 | 4,563,000 | 300,000 | SH | SOLE | 300,000 | 0 | 0 | ||
| CARTESIAN THERAPEUTICS INC | COM NEW | 816212302 | 841,352 | 52,193 | SH | SOLE | 52,193 | 0 | 0 | ||
| CATALYST PHARMACEUTICALS INC | COM | 14888U101 | 8,306,858 | 417,850 | SH | SOLE | 417,850 | 0 | 0 | ||
| CELLDEX THERAPEUTICS INC NEW | COM NEW | 15117B202 | 10,383,945 | 305,500 | SH | Put | SOLE | 305,500 | 0 | 0 | |
| CELLDEX THERAPEUTICS INC NEW | COM NEW | 15117B202 | 10,383,945 | 305,500 | SH | Call | SOLE | 305,500 | 0 | 0 | |
| CERVOMED INC | COM | 15713L109 | 2,954,237 | 202,345 | SH | SOLE | 202,345 | 0 | 0 | ||
| CHEMOMAB THERAPEUTICS LTD | SPONSORED ADS | 16385C104 | 335,025 | 213,392 | SH | SOLE | 213,392 | 0 | 0 | ||
| COMPASS PATHWAYS PLC | SPONSORED ADS | 20451W101 | 1,278,320 | 202,908 | SH | SOLE | 202,908 | 0 | 0 | ||
| CORBUS PHARMACEUTICALS HLDGS | COM NEW | 21833P301 | 4,808,853 | 233,100 | SH | Put | SOLE | 233,100 | 0 | 0 | |
| CORBUS PHARMACEUTICALS HLDGS | COM NEW | 21833P301 | 2,223,914 | 107,800 | SH | Call | SOLE | 107,800 | 0 | 0 | |
| CORBUS PHARMACEUTICALS HLDGS | COM NEW | 21833P301 | 5,873,670 | 284,715 | SH | SOLE | 284,715 | 0 | 0 | ||
| CORVUS PHARMACEUTICALS INC | COM | 221015100 | 1,152,624 | 218,300 | SH | Call | SOLE | 218,300 | 0 | 0 | |
| CRINETICS PHARMACEUTICALS IN | COM | 22663K107 | 21,815,255 | 426,913 | SH | SOLE | 426,913 | 0 | 0 | ||
| CYBIN INC | COM NEW | 23256X407 | 3,264,364 | 367,195 | SH | SOLE | 367,195 | 0 | 0 | ||
| CYTOKINETICS INC | COM NEW | 23282W605 | 2,761,440 | 52,300 | SH | Call | SOLE | 52,300 | 0 | 0 | |
| CYTOKINETICS INC | COM NEW | 23282W605 | 8,983,761 | 170,147 | SH | SOLE | 170,147 | 0 | 0 | ||
| CYTOMX THERAPEUTICS INC | COM | 23284F105 | 10,529 | 8,924 | SH | SOLE | 8,924 | 0 | 0 | ||
| DELCATH SYS INC | COM NEW | 24661P807 | 906,340 | 100,370 | SH | SOLE | 100,370 | 0 | 0 | ||
| DYNE THERAPEUTICS INC | COM | 26818M108 | 4,777,360 | 133,000 | SH | Put | SOLE | 133,000 | 0 | 0 | |
| ELEVATION ONCOLOGY INC | COM | 28623U101 | 413,984 | 690,089 | SH | SOLE | 690,089 | 0 | 0 | ||
| ELIEM THERAPEUTICS INC | COM | 28658R106 | 891,258 | 175,100 | SH | SOLE | 175,100 | 0 | 0 | ||
| ENLIVEN THERAPEUTICS INC | COM | 29337E102 | 12,758,915 | 499,566 | SH | SOLE | 499,566 | 0 | 0 | ||
| EVOLUS INC | COM | 30052C107 | 4,184,120 | 258,279 | SH | SOLE | 258,279 | 0 | 0 | ||
| FULCRUM THERAPEUTICS INC | COM | 359616109 | 81,396 | 22,800 | SH | Put | SOLE | 22,800 | 0 | 0 | |
| FULCRUM THERAPEUTICS INC | COM | 359616109 | 1,509,396 | 422,800 | SH | Call | SOLE | 422,800 | 0 | 0 | |
| FULCRUM THERAPEUTICS INC | COM | 359616109 | 267,750 | 75,000 | SH | SOLE | 75,000 | 0 | 0 | ||
| GALECTIN THERAPEUTICS INC | COM NEW | 363225202 | 1,375,000 | 500,000 | SH | Put | SOLE | 500,000 | 0 | 0 | |
| GALECTIN THERAPEUTICS INC | COM NEW | 363225202 | 1,375,000 | 500,000 | SH | Call | SOLE | 500,000 | 0 | 0 | |
| HOOKIPA PHARMA INC | COM NEW | 43906K209 | 228,227 | 53,076 | SH | SOLE | 53,076 | 0 | 0 | ||
| IBIO INC | CON NEW | 451033708 | 1,332,000 | 600,000 | SH | SOLE | 600,000 | 0 | 0 | ||
| IMMATICS N.V | SHS | N44445109 | 563,825 | 49,415 | SH | SOLE | 49,415 | 0 | 0 | ||
| IMMUNIC INC | COM | 4525EP101 | 814,268 | 493,496 | SH | SOLE | 493,496 | 0 | 0 | ||
| IMMUNOVANT INC | COM | 45258J102 | 14,255,000 | 500,000 | SH | Call | SOLE | 500,000 | 0 | 0 | |
| INFLARX NV | COM | N44821101 | 1,078,630 | 704,987 | SH | SOLE | 704,987 | 0 | 0 | ||
| INHIBRX BIOSCIENCES INC | COM | 45720N103 | 659,646 | 42,123 | SH | SOLE | 42,123 | 0 | 0 | ||
| INSMED INC | COM PAR $.01 | 457669307 | 11,302,955 | 154,835 | SH | SOLE | 154,835 | 0 | 0 | ||
| ITEOS THERAPEUTICS INC | COM | 46565G104 | 802,241 | 78,574 | SH | SOLE | 78,574 | 0 | 0 | ||
| JANUX THERAPEUTICS INC | COM | 47103J105 | 16,591,036 | 365,200 | SH | Put | SOLE | 365,200 | 0 | 0 | |
| JASPER THERAPEUTICS INC | COM NEW | 471871202 | 1,037,842 | 55,175 | SH | SOLE | 55,175 | 0 | 0 | ||
| KARYOPHARM THERAPEUTICS INC | COM | 48576U106 | 339,764 | 409,355 | SH | SOLE | 409,355 | 0 | 0 | ||
| KEZAR LIFE SCIENCES INC | COM | 49372L100 | 826,544 | 1,068,992 | SH | SOLE | 1,068,992 | 0 | 0 | ||
| KODIAK SCIENCES INC | COM | 50015M109 | 1,243,890 | 476,586 | SH | SOLE | 476,586 | 0 | 0 | ||
| LARIMAR THERAPEUTICS INC | COM | 517125100 | 383,358 | 58,528 | SH | SOLE | 58,528 | 0 | 0 | ||
| LENZ THERAPEUTICS INC | COM | 52635N103 | 4,855,139 | 204,513 | SH | SOLE | 204,513 | 0 | 0 | ||
| LEXEO THERAPEUTICS INC | COM | 52886X107 | 2,325,233 | 257,216 | SH | SOLE | 257,216 | 0 | 0 | ||
| LYELL IMMUNOPHARMA INC | COM | 55083R104 | 725,971 | 526,066 | SH | SOLE | 526,066 | 0 | 0 | ||
| LYRA THERAPEUTICS INC | COM | 55234L105 | 271,606 | 1,056,829 | SH | SOLE | 1,056,829 | 0 | 0 | ||
| MACROGENICS INC | COM | 556099109 | 263,460 | 80,079 | SH | SOLE | 80,079 | 0 | 0 | ||
| MADRIGAL PHARMACEUTICALS INC | COM | 558868105 | 4,987,170 | 23,500 | SH | Put | SOLE | 23,500 | 0 | 0 | |
| MARINUS PHARMACEUTICALS INC | COM NEW | 56854Q200 | 1,242,831 | 706,154 | SH | SOLE | 706,154 | 0 | 0 | ||
| MILESTONE PHARMACEUTICALS IN | COM | 59935V107 | 708,349 | 466,019 | SH | SOLE | 466,019 | 0 | 0 | ||
| MIND MEDICINE MINDMED INC | COM NEW | 60255C885 | 355,516 | 62,481 | SH | SOLE | 62,481 | 0 | 0 | ||
| MINERALYS THERAPEUTICS INC | COM | 603170101 | 2,179,800 | 180,000 | SH | SOLE | 180,000 | 0 | 0 | ||
| MONTE ROSA THERAPEUTICS INC | COM | 61225M102 | 1,651,443 | 311,593 | SH | SOLE | 311,593 | 0 | 0 | ||
| NEKTAR THERAPEUTICS | COM | 640268108 | 1,706,126 | 1,312,405 | SH | SOLE | 1,312,405 | 0 | 0 | ||
| NEUMORA THERAPEUTICS INC. | COM | 640979100 | 5,284,000 | 400,000 | SH | Put | SOLE | 400,000 | 0 | 0 | |
| NEUMORA THERAPEUTICS INC. | COM | 640979100 | 5,284,000 | 400,000 | SH | Call | SOLE | 400,000 | 0 | 0 | |
| NEWAMSTERDAM PHARMA COMPANY | ORDINARY SHARES | N62509109 | 483,060 | 29,100 | SH | Call | SOLE | 29,100 | 0 | 0 | |
| NURIX THERAPEUTICS INC | COM | 67080M103 | 5,842,200 | 260,000 | SH | SOLE | 260,000 | 0 | 0 | ||
| NUVALENT INC | COM | 670703107 | 5,343,947 | 52,238 | SH | SOLE | 52,238 | 0 | 0 | ||
| NUVATION BIO INC | COM CL A | 67080N101 | 190,716 | 83,282 | SH | SOLE | 83,282 | 0 | 0 | ||
| NYXOAH S A | SHS | B6S7WD106 | 484,175 | 50,699 | SH | SOLE | 50,699 | 0 | 0 | ||
| OLEMA PHARMACEUTICALS INC | COM | 68062P106 | 1,098,479 | 92,000 | SH | SOLE | 92,000 | 0 | 0 | ||
| PERSPECTIVE THERAPEUTICS INC | COM NEW | 46489V302 | 1,029,285 | 77,100 | SH | Put | SOLE | 77,100 | 0 | 0 | |
| PROQR THRAPEUTICS N V | SHS EURO | N71542109 | 880,121 | 483,583 | SH | SOLE | 483,583 | 0 | 0 | ||
| PROTARA THERAPEUTICS INC | COM STK | 74365U107 | 284,953 | 155,712 | SH | SOLE | 155,712 | 0 | 0 | ||
| PROTHENA CORP PLC | SHS | G72800108 | 197,414 | 11,800 | SH | Put | SOLE | 11,800 | 0 | 0 | |
| PROTHENA CORP PLC | SHS | G72800108 | 197,414 | 11,800 | SH | Call | SOLE | 11,800 | 0 | 0 | |
| PYXIS ONCOLOGY INC | COMMON STOCK | 747324101 | 1,316,062 | 358,600 | SH | Call | SOLE | 358,600 | 0 | 0 | |
| PYXIS ONCOLOGY INC | COMMON STOCK | 747324101 | 3,513,688 | 957,408 | SH | SOLE | 957,408 | 0 | 0 | ||
| RAPT THERAPEUTICS INC | COM | 75382E109 | 310,796 | 154,625 | SH | SOLE | 154,625 | 0 | 0 | ||
| RELAY THERAPEUTICS INC | COM | 75943R102 | 4,908,918 | 693,350 | SH | SOLE | 693,350 | 0 | 0 | ||
| RELMADA THERAPEUTICS INC | COM | 75955J402 | 130,795 | 40,369 | SH | SOLE | 40,369 | 0 | 0 | ||
| RENEO PHARMACEUTICALS INC | COM | 75974E103 | 1,743,635 | 1,025,668 | SH | SOLE | 1,025,668 | 0 | 0 | ||
| REZOLUTE INC | COM NEW | 76200L309 | 4,303,066 | 887,230 | SH | SOLE | 887,230 | 0 | 0 | ||
| ROCKET PHARMACEUTICALS INC | COM | 77313F106 | 3,640,363 | 197,096 | SH | SOLE | 197,096 | 0 | 0 | ||
| ROIVANT SCIENCES LTD | SHS | G76279101 | 1,161,028 | 100,609 | SH | SOLE | 100,609 | 0 | 0 | ||
| SAGIMET BIOSCIENCES INC | COM SER A | 786700104 | 1,073,555 | 387,565 | SH | SOLE | 387,565 | 0 | 0 | ||
| SANA BIOTECHNOLOGY INC | COM | 799566104 | 2,704,000 | 650,000 | SH | Put | SOLE | 650,000 | 0 | 0 | |
| SANA BIOTECHNOLOGY INC | COM | 799566104 | 2,704,000 | 650,000 | SH | Call | SOLE | 650,000 | 0 | 0 | |
| SAREPTA THERAPEUTICS INC | COM | 803607100 | 6,766,041 | 54,176 | SH | SOLE | 54,176 | 0 | 0 | ||
| SCHOLAR ROCK HLDG CORP | COM | 80706P103 | 1,618,821 | 202,100 | SH | Put | SOLE | 202,100 | 0 | 0 | |
| SCHOLAR ROCK HLDG CORP | COM | 80706P103 | 1,618,821 | 202,100 | SH | Call | SOLE | 202,100 | 0 | 0 | |
| SENSEI BIOTHERAPEUTICS INC | COM | 81728A108 | 388,700 | 650,000 | SH | SOLE | 650,000 | 0 | 0 | ||
| SILENCE THERAPEUTICS PLC | ADS | 82686Q101 | 3,374,286 | 587,343 | SH | SOLE | 587,343 | 0 | 0 | ||
| SOLENO THERAPEUTICS INC | COM | 834203309 | 5,553,900 | 110,000 | SH | Call | SOLE | 110,000 | 0 | 0 | |
| SOLENO THERAPEUTICS INC | COM | 834203309 | 11,180,355 | 221,437 | SH | SOLE | 221,437 | 0 | 0 | ||
| SOLID BIOSCIENCES INC | COM NEW | 83422E204 | 2,091,000 | 300,000 | SH | Call | SOLE | 300,000 | 0 | 0 | |
| SPDR SER TR | S&P BIOTECH | 78464A870 | 49,400,000 | 500,000 | SH | Put | SOLE | 500,000 | 0 | 0 | |
| SPRINGWORKS THERAPEUTICS INC | COM | 85205L107 | 1,403,352 | 43,800 | SH | Call | SOLE | 43,800 | 0 | 0 | |
| SPYRE THERAPEUTICS INC | COM NEW | 00773J202 | 8,889,085 | 302,247 | SH | SOLE | 302,247 | 0 | 0 | ||
| STOKE THERAPEUTICS INC | COM | 86150R107 | 83,768 | 6,816 | SH | SOLE | 6,816 | 0 | 0 | ||
| STRUCTURE THERAPEUTICS INC | SPONSORED ADS | 86366E106 | 5,056,129 | 115,200 | SH | SOLE | 115,200 | 0 | 0 | ||
| SYNLOGIC INC | COM NEW | 87166L209 | 30,468 | 20,448 | SH | SOLE | 20,448 | 0 | 0 | ||
| TARSUS PHARMACEUTICALS INC | COM | 87650L103 | 33,885,812 | 1,030,277 | SH | SOLE | 1,030,277 | 0 | 0 | ||
| TECTONIC THERAPEUTIC INC | COM | 878972108 | 8,094,495 | 267,145 | SH | SOLE | 267,145 | 0 | 0 | ||
| TEMPEST THERAPEUTICS INC | COM | 87978U108 | 147,840 | 105,600 | SH | SOLE | 105,600 | 0 | 0 | ||
| TERNS PHARMACEUTICALS INC | COM | 880881107 | 2,572,865 | 308,497 | SH | SOLE | 308,497 | 0 | 0 | ||
| TOURMALINE BIO INC | COM | 89157D105 | 2,789,099 | 108,483 | SH | SOLE | 108,483 | 0 | 0 | ||
| ULTRAGENYX PHARMACEUTICAL IN | COM | 90400D108 | 9,943,450 | 179,000 | SH | SOLE | 179,000 | 0 | 0 | ||
| VENTYX BIOSCIENCES INC | COM | 92332V107 | 419,970 | 192,647 | SH | SOLE | 192,647 | 0 | 0 | ||
| VERTEX PHARMACEUTICALS INC | COM | 92532F100 | 46,508,000 | 100,000 | SH | Put | SOLE | 100,000 | 0 | 0 | |
| VERTEX PHARMACEUTICALS INC | COM | 92532F100 | 46,508,000 | 100,000 | SH | Call | SOLE | 100,000 | 0 | 0 | |
| VERU INC | COM | 92536C103 | 727,767 | 946,382 | SH | SOLE | 946,382 | 0 | 0 | ||
| VERVE THERAPEUTICS INC | COM | 92539P101 | 822,800 | 170,000 | SH | SOLE | 170,000 | 0 | 0 | ||
| VIRIDIAN THERAPEUTICS INC | COM | 92790C104 | 4,550,000 | 200,000 | SH | Call | SOLE | 200,000 | 0 | 0 | |
| VIRIDIAN THERAPEUTICS INC | COM | 92790C104 | 11,374,478 | 499,977 | SH | SOLE | 499,977 | 0 | 0 | ||
| VOYAGER THERAPEUTICS INC | COM | 92915B106 | 326,763 | 55,857 | SH | SOLE | 55,857 | 0 | 0 | ||
| WAVE LIFE SCIENCES LTD | SHS | Y95308105 | 4,462,973 | 544,265 | SH | SOLE | 544,265 | 0 | 0 | ||
| XENON PHARMACEUTICALS INC | COM | 98420N105 | 4,219,953 | 107,187 | SH | SOLE | 107,187 | 0 | 0 | ||
