Odyssey Semiconductor (ODII) 8-K Changes in Registrant's Certifying Accountant

EXHIBIT 16.1

May 5, 2023

Securities and Exchange Commission

100 F Street, N.E.

Washington, DC 20549

Commissioners:

We have read the statements made by Odyssey Semiconductor Technologies, Inc. under Item 4.01 of its Form 8-K dated May 5, 2023.We agree with the statements concerning our Firm in such Form 8-K; we are not in a position to agree or disagree with other statements of Odyssey Semiconductor Technologies, Inc. contained therein.

Very truly yours,

/s/ Marcum LLP

Marcum LLP