| Document And Entity Information | Mar. 16, 2023 |
| Cover [Abstract] | |
| Document Type | 8-K |
| Amendment Flag | false |
| Document Period End Date | Mar. 16, 2023 |
| Entity Registrant Name | Pyxis Oncology, Inc. |
| Entity Central Index Key | 0001782223 |
| Entity Emerging Growth Company | true |
| Securities Act File Number | 001-40881 |
| Entity Incorporation, State or Country Code | DE |
| Entity Tax Identification Number | 83-1160910 |
| Entity Address, Address Line One | 150 Cambridgepark Drive |
| Entity Address, City or Town | Cambridge |
| Entity Address, State or Province | MA |
| Entity Address, Postal Zip Code | 02140 |
| City Area Code | 617- |
| Local Phone Number | 221-9059 |
| Entity Information, Former Legal or Registered Name | |
| Written Communications | false |
| Soliciting Material | false |
| Pre-commencement Tender Offer | false |
| Pre-commencement Issuer Tender Offer | false |
| Entity Ex Transition Period | true |
| Title of 12(b) Security | Common Stock, par value $0.001 per share |
| Trading Symbol | PYXS |
| Security Exchange Name | NASDAQ |
