Document and Entity Information
Document and Entity Information - shares | 3 Months Ended | |
Mar. 31, 2020 | May 04, 2020 | |
Cover [Abstract] | ||
Document Type | 10-Q | |
Amendment Flag | false | |
Document Period End Date | Mar. 31, 2020 | |
Document Fiscal Year Focus | 2020 | |
Document Fiscal Period Focus | Q1 | |
Entity Registrant Name | 89bio, Inc. | |
Entity Central Index Key | 0001785173 | |
Entity Current Reporting Status | Yes | |
Entity Interactive Data Current | Yes | |
Current Fiscal Year End Date | --12-31 | |
Entity Filer Category | Non-accelerated Filer | |
Entity Common Stock, Shares Outstanding | 13,793,858 | |
Entity Shell Company | false | |
Entity Small Business | true | |
Entity Emerging Growth Company | true | |
Entity Ex Transition Period | false | |
Title of 12(b) Security | Common stock, par value $0.001 per share | |
Trading Symbol | ETNB | |
Security Exchange Name | NASDAQ | |
Entity File Number | 001-39122 | |
Entity Incorporation, State or Country Code | DE | |
Entity Tax Identification Number | 36-4946844 | |
Entity Address, Address Line One | 142 Sansome Street | |
Entity Address, Address Line Two | Second Floor | |
Entity Address, City or Town | San Francisco | |
Entity Address, State or Province | CA | |
Entity Address, Postal Zip Code | 94104 | |
City Area Code | 415 | |
Local Phone Number | 500-4614 | |
Document Quarterly Report | true | |
Document Transition Report | false |
Condensed Consolidated Balance
Condensed Consolidated Balance Sheets (Unaudited) - USD ($) $ in Thousands | Mar. 31, 2020 | Dec. 31, 2019 |
Current assets: | ||
Cash and cash equivalents | $ 85,532 | $ 93,335 |
Restricted cash | 24 | 25 |
Prepaid and other current assets | 1,857 | 1,966 |
Total current assets | 87,413 | 95,326 |
Property and equipment, net | 204 | 155 |
Other assets | 72 | 72 |
Total assets | 87,689 | 95,553 |
Current liabilities: | ||
Accounts payable | 4,055 | 989 |
Accrued expenses | 3,732 | 4,620 |
Total current liabilities | 7,787 | 5,609 |
Commitments and contingencies (Note 5) | ||
Stockholders’ equity: | ||
Common stock | 14 | 14 |
Additional paid-in capital | 164,028 | 163,526 |
Accumulated deficit | (84,140) | (73,596) |
Total stockholders’ equity | 79,902 | 89,944 |
Total liabilities and stockholders’ equity | $ 87,689 | $ 95,553 |
Condensed Consolidated Statemen
Condensed Consolidated Statements of Operations and Comprehensive Loss (Unaudited) - USD ($) $ in Thousands | 3 Months Ended | |
Mar. 31, 2020 | Mar. 31, 2019 | |
Operating expenses: | ||
Research and development | $ 7,778 | $ 4,309 |
General and administrative | 2,924 | 523 |
Total operating expenses | 10,702 | 4,832 |
Loss from operations | 10,702 | 4,832 |
Other income, net | (157) | (416) |
Net loss before tax | 10,545 | 4,416 |
Income tax (benefit) expense | (1) | 23 |
Net loss and comprehensive loss | $ 10,544 | $ 4,439 |
Net loss per share, basic and diluted | $ 0.76 | $ 7.26 |
Weighted-average shares used to compute net loss per share, basic and diluted | 13,789,786 | 611,226 |
Condensed Consolidated Statem_2
Condensed Consolidated Statements of Convertible Preferred Stock, and Stockholders' Equity (Deficit) (Unaudited) - USD ($) $ in Thousands | Total | Common Stock | Additional Paid-in Capital | Accumulated Deficit | Convertible Preferred Stock |
Beginning balance at Dec. 31, 2018 | $ (16,057) | $ 1 | $ 118 | $ (16,176) | |
Beginning balance, shares at Dec. 31, 2018 | 24,000,000 | ||||
Beginning balance at Dec. 31, 2018 | $ 23,073 | ||||
Beginning balance, shares at Dec. 31, 2018 | 611,226 | ||||
Share-based compensation | 35 | 35 | 0 | ||
Net loss and comprehensive loss | (4,439) | 0 | (4,439) | ||
Ending balance at Mar. 31, 2019 | (20,461) | $ 1 | 153 | (20,615) | |
Ending balance, shares at Mar. 31, 2019 | 24,000,000 | ||||
Ending balance at Mar. 31, 2019 | $ 23,073 | ||||
Ending balance, shares at Mar. 31, 2019 | 611,226 | ||||
Beginning balance at Dec. 31, 2019 | $ 89,944 | $ 14 | 163,526 | (73,596) | |
Beginning balance, shares at Dec. 31, 2019 | 0 | 0 | |||
Beginning balance at Dec. 31, 2019 | $ 0 | ||||
Beginning balance, shares at Dec. 31, 2019 | 13,788,982 | ||||
Issuance of common stock upon exercise of stock options | $ 9 | $ 0 | 9 | 0 | |
Issuance of common stock upon exercise of stock options, shares | 4,876 | 4,876 | |||
Share-based compensation | $ 493 | 493 | 0 | ||
Net loss and comprehensive loss | (10,544) | 0 | (10,544) | ||
Ending balance at Mar. 31, 2020 | $ 79,902 | $ 14 | $ 164,028 | $ (84,140) | |
Ending balance, shares at Mar. 31, 2020 | 0 | 0 | |||
Ending balance at Mar. 31, 2020 | $ 0 | ||||
Ending balance, shares at Mar. 31, 2020 | 13,793,858 |
Condensed Consolidated Statem_3
Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($) $ in Thousands | 3 Months Ended | |
Mar. 31, 2020 | Mar. 31, 2019 | |
Cash flows from operating activities: | ||
Net loss | $ (10,544) | $ (4,439) |
Adjustments to reconcile net loss to net cash used in operating activities: | ||
Depreciation | 12 | 3 |
Share-based compensation | 493 | 35 |
Deferred tax assets | (19) | |
Revaluation of convertible preferred stock liability | (437) | |
Changes in operating assets and liabilities: | ||
Prepaids and other current assets | 109 | (82) |
Accounts payable | 3,066 | (427) |
Accrued expenses | (888) | 1,199 |
Net cash used in operating activities | (7,752) | (4,167) |
Cash flows from investing activities: | ||
Purchases of property and equipment | (61) | (2) |
Net cash used in investing activities | (61) | (2) |
Cash flows from financing activities: | ||
Proceeds from issuance of common stock upon exercise of stock options | 9 | |
Net cash provided by financing activities | 9 | |
Net decrease in cash and cash equivalents, and restricted cash | (7,804) | (4,169) |
Cash and cash equivalents, and restricted cash at beginning of period | 93,360 | 11,257 |
Cash and cash equivalents, and restricted cash at end of period | 85,556 | 7,088 |
Components of cash and cash equivalents, and restricted cash: | ||
Cash and cash equivalents | 85,532 | 7,064 |
Restricted cash | 24 | 24 |
Cash and cash equivalents, and restricted cash at end of period | 85,556 | $ 7,088 |
Noncash investing and financing activities: | ||
Property and equipment purchases included in accounts payable and accrued expenses | $ 54 |
Organization and Basis of Prese
Organization and Basis of Presentation | 3 Months Ended |
Mar. 31, 2020 | |
Organization Consolidation And Presentation Of Financial Statements [Abstract] | |
Organization and Basis of Presentation | 1. Organization and Basis of Presentation Description of Business 89bio, Inc. (“89bio” or the “Company”) is a clinical-stage biopharmaceutical company focused on the development and commercialization of innovative therapies for the treatment of liver and cardio-metabolic diseases. The Company’s lead product candidate, BIO89-100, a specifically engineered glycoPEGylated analog of fibroblast growth factor 21, is currently being developed for the treatment of nonalcoholic steatohepatitis. 89bio, Inc. was formed as a Delaware corporation on June 28, 2019, for the purpose of completing an initial public offering (“IPO”) and related transactions in order to carry on the business of 89Bio Ltd., which was incorporated in Israel in January 2018. The Company completed an internal reorganization transaction in September 2019, pursuant to which 89Bio Ltd. became a wholly owned subsidiary of 89bio, Inc. (the “Reorganization”). As part of the Reorganization, all of the equity holders of 89Bio Ltd. exchanged 100% of the equity of 89Bio Ltd. for 100% of the equity of 89bio, Inc. The Reorganization was considered a transaction between entities under common control. Initial Public Offering On November 13, 2019, 89bio, Inc. completed the IPO, pursuant to which it issued and sold an aggregate of 6,100,390 shares of common stock (inclusive of 795,703 shares pursuant to the underwriters’ option to purchase additional shares) at the IPO price of $16.00 per share, resulting in net proceeds of $87.7 million after deducting underwriting discounts and commissions of $6.8 million and other offering expenses of $3.1 million. Upon the closing of the IPO, the Company’s outstanding convertible preferred stock automatically converted into 7,077,366 shares of common stock of 89bio, Inc. based on a proportional adjustment to the conversion ratio of the convertible preferred stock on a 1-for-6.217 basis. Liquidity The accompanying condensed consolidated financial statements have been prepared assuming the Company will continue as a going concern, which contemplates the realization of assets and liquidation of liabilities in the normal course of business. To date, the Company has not generated revenues from its activities and has incurred substantial operating losses. Management expects the Company to continue to generate substantial operating losses for the foreseeable future until it completes development of its products and seeks regulatory approvals to market such products. The Company had cash and cash equivalents of $85.5 million as of March 31, 2020. Management expects to continue to fund its operations primarily through utilization of its current financial resources and through additional raises of capital. The Company intends to raise such capital through the issuance of additional equity financing and/or debt financing. However, if such financing is not available at adequate levels, the Company will need to reevaluate its operating plan and may be required to delay the development of its products. The Company expects that its cash and cash equivalents as of March 31, 2020 will be sufficient to fund operating expenses and capital expenditure requirements for a period of at least one year from the date these unaudited condensed consolidated financial statements are filed with the Securities and Exchange Commission (“SEC”). |
Summary of Significant Accounti
Summary of Significant Accounting Policies | 3 Months Ended |
Mar. 31, 2020 | |
Accounting Policies [Abstract] | |
Summary of Significant Accounting Policies | 2. Summary of Significant Accounting Policies Unaudited Condensed Consolidated Financial Statements The accompanying interim unaudited condensed consolidated financial statements have been prepared in accordance with generally accepted accounting principles in the United States (“U.S. GAAP”) and applicable rules and regulations of the SEC regarding interim financial reporting. The accompanying interim condensed consolidated financial statements are unaudited. The interim unaudited condensed consolidated financial statements have been prepared on the same basis as the audited consolidated financial statements as of and for the year ended December 31, 2019 and, in the opinion of management, reflect all adjustments, which include only normal recurring adjustments, necessary to present fairly the Company’s consolidated financial position, results of operations and comprehensive loss, and cash flows. The results of operations for the three months ended March 31, 2020 are not necessarily indicative of the results to be expected for the year ending December 31, 2020 or for any other future annual or interim period. The condensed consolidated balance sheet as of December 31, 2019 was derived from the audited financial statements as of that date. These condensed consolidated financial statements should be read in conjunction with the Company’s audited consolidated financial statements included in the Annual Report on Form 10-K for the year ended December 31, 2019, which was filed with the SEC on March 18, 2020. Principles of Consolidation The accompanying condensed consolidated financial statements include the accounts of the Company and its wholly owned subsidiaries. All intercompany balances and transactions have been eliminated in consolidation. Use of Estimates The preparation of consolidated financial statements in conformity with U.S. GAAP requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities and disclosure of contingent assets and liabilities as of the date of the consolidated financial statements and the reported amounts of expenses during the reporting period. Significant estimates and assumptions made in the accompanying condensed consolidated financial statements include but are not limited to the fair value of stock options, the convertible preferred stock liability and certain accruals. The Company evaluates its estimates and assumptions on an ongoing basis using historical experience and other factors and adjusts those estimates and assumptions when facts and circumstances dictate. Actual results could differ from those estimates. Fair Value Measurements Financial assets and liabilities are recorded at fair value on a recurring basis in the balance sheets. The carrying values of Company’s financial assets and liabilities, including cash and cash equivalents, restricted cash, prepaid and other current assets, accounts payable, and accrued expenses approximate their fair values due to the short-term maturity of these instruments. Fair value is defined as the price that would be received to sell an asset or paid to transfer a liability (an exit price) in an orderly transaction between market participants at the reporting date. Assets and liabilities recorded at fair value are categorized based upon the level of judgment associated with the inputs used to measure their fair value. Hierarchical levels are directly related to the amount of subjectivity with the inputs to the valuation of these assets or liabilities as follows: Level 1 —Observable inputs such as unadjusted, quoted prices in active markets for identical assets or liabilities at the measurement date; Level 2 —Inputs (other than quoted prices included in Level 1) are either directly or indirectly observable inputs for similar assets or liabilities. These include quoted prices for identical or similar assets or liabilities in active markets and quoted prices for identical or similar assets or liabilities in markets that are not active; Level 3 —Unobservable inputs that are supported by little or no market activity and that are significant to the fair value of the assets or liabilities. Convertible Preferred Stock Liability The freestanding instruments related to the commitment by the Series A convertible preferred stockholders to purchase and by the Company to sell its Series A convertible preferred stock in subsequent closings, contingent upon the achievement of certain developmental milestones and approval by the board of directors, at a fixed price per stock, were considered a liability (or an asset), measured at fair value as the shares underlying the rights contained liquidation preferences upon certain “deemed liquidation events” that were not solely within the Company’s control and which were considered in-substance contingent redemption features. The instruments were subject to revaluation at each balance sheet date until settlement or extinguishment, with revaluations recognized as either a component of other income, net in the condensed consolidated statements of operations and comprehensive loss, or additional paid-in capital in the condensed consolidated balance sheets. Upon the completion of the Company’s IPO, the remaining shares of convertible preferred stock that were previously issuable under the third closing were no longer issuable. Accordingly, the preferred stock liability was extinguished and because the transaction occurred between related parties, the resulting $25.6 million was accounted for as a capital contribution by the preferred stockholders. Risk and Uncertainties In December 2019, a novel strain of coronavirus, SARS-CoV-2, causing a disease referred to as COVID-19, was reported to have surfaced in Wuhan, China. Since then, COVID-19 has spread to other countries, including the United States, and has been declared a pandemic by the World Health Organization. If COVID-19 continues to spread in the United States and worldwide, the Company may experience disruptions that could negatively impact its ability to recruit and onboard new employees and productivity, disrupt the business and delay preclinical and clinical programs and timelines, the magnitude of which will depend, in part, on the length and severity of restrictions and limitations on the Company’s ability to conduct business in the ordinary course. At this point, the extent to which COVID-19 may impact the Company’s operating results and financial condition is uncertain. Recently Adopted Accounting Pronouncement In August 2018, the FASB issued ASU No. 2018-13, Disclosure Framework – Changes to the Disclosure Requirements for Fair Value Measurement Recent Accounting Pronouncements In February 2016, the FASB issued ASU 2016-02— Leases In December 2019, the FASB issued ASU 2019-12, Income Taxes (Topic 740): Simplifying the Accounting for Income Taxes |
Fair Value Measurements
Fair Value Measurements | 3 Months Ended |
Mar. 31, 2020 | |
Fair Value Disclosures [Abstract] | |
Fair Value Measurements | 3. Fair Value Measurements The Company’s convertible preferred stock liability represented a Level 3 financial liability measured at fair value on a recurring basis prior to its extinguishment as of December 31, 2019. Accordingly, there was no Level 3 financial liability as of March 31, 2020. For the three months ended March 31, 2019, changes in the fair value of the Company’s Level 3 financial liability were measured on a recurring basis as follows (in thousands): Three Months Ended March 31, 2019 Beginning balance $ 1,671 Revaluation of convertible preferred stock liability recorded in other income, net (437 ) Ending balance $ 1,234 The Company’s convertible preferred stock liability resulted from the initial sale of Series A convertible preferred stock where the investors committed to purchase additional shares of Series A convertible preferred stock in subsequent closings, contingent upon the achievement by the Company of certain development milestones and approval by the board of directors. The investors’ commitment to purchase and the Company’s commitment to sell shares of Series A convertible preferred stock represented a freestanding instrument accounted for at fair value and re-measured at each reporting date. The Company estimated the fair value of this commitment using the Black-Scholes option-pricing model using the following assumptions: Three Months Ended March 31, 2019 Stock price $ 0.99 Exercise price $ 1.00 Expected term (years) 0.24-2.25 Expected volatility 72.0 % Risk-free interest rate 2.3-2.4 % |
Consolidated Balance Sheet Comp
Consolidated Balance Sheet Components | 3 Months Ended |
Mar. 31, 2020 | |
Balance Sheet Related Disclosures [Abstract] | |
Consolidated Balance Sheet Components | 4. Consolidated Balance Sheet Components Accrued Expenses Accrued expenses consist of the following (in thousands): March 31, December 31, 2020 2019 Accrued research and development expense $ 2,169 $ 2,326 Accrued employee and related expenses 730 1,396 Accrued professional and legal fees 552 573 Accrued other 281 325 Total accrued expenses $ 3,732 $ 4,620 |
Commitments and Contingencies
Commitments and Contingencies | 3 Months Ended |
Mar. 31, 2020 | |
Commitments And Contingencies Disclosure [Abstract] | |
Commitments and Contingencies | 5. Commitments and Contingencies Leases Future minimum Remainder of 2020 $ 161 2021 216 2022 8 Total future minimum annual payments $ 385 Rent expense was $60,000 and $27,000 for the three months ended March 31, 2020 and 2019, respectively. Asset Transfer and License Agreement with Teva Pharmaceutical Industries Ltd In April 2018, the Company concurrently entered into two Asset Transfer and License Agreements (the “Teva Agreements”) with Teva Pharmaceutical Industries Ltd (“Teva”) under which it acquired certain patents and intellectual property relating to two programs: (1) Teva’s glycoPEGylated FGF21 program, including the compound TEV-47948 (BIO89-100), a glycoPEGylated long-acting FGF21 and (2) Teva’s development program of small molecule inhibitors of Fatty Acid Synthase. Pursuant to the Teva Agreements, the Company paid Teva an initial nonrefundable upfront payment of $6.0 million and the Company could be obligated to pay Teva up to $67.5 million under each program, for a total of $135.0 million, upon the achievement of certain clinical development and commercial milestones. In addition, the Company is obligated to pay Teva tiered royalties at percentages in the low-to-mid single-digits on worldwide net sales on all products containing the Teva compounds. The Teva Agreements can be terminated (i) by the Company without cause, after the first anniversary of the effective date, upon 120 days’ written notice to Teva, (ii) by either party, if the other party materially breaches any of its obligations under the Agreements and fails to cure such breach within 60 days after receiving notice thereof, or (iii) by either party, if a bankruptcy petition is filed against the other party and is not dismissed within 60 days. In addition, Teva can also terminate the agreement related to the Company’s glycoPEGylated FGF21 program in the event the Company, or any of its affiliates or sublicensees, challenges any of the Teva patents licensed to the Company, and the challenge is not withdrawn within 30 days of written notice from Teva. The Company accounted for the acquisition of technology as an asset acquisition because it did not meet the definition of a business. The Company recorded the total consideration transferred to Teva as research and development expense in the condensed consolidated statements of operations and comprehensive loss because the acquired technology represented in-process research and development and had no alternative future use. During the three months ended March 31, 2020 and 2019, there were no license payment expenses related to the Teva Agreements. |
Convertible Preferred Stock
Convertible Preferred Stock | 3 Months Ended |
Mar. 31, 2020 | |
Temporary Equity Disclosure [Abstract] | |
Convertible Preferred Stock | 6. Convertible Preferred Stock In April 2018, the Company entered into the Series A Share Purchase Agreement (the “Series A SPA”), pursuant to which the investors committed to invest an aggregate amount of up to $60.0 million for the issuance of shares of Series A convertible preferred stock at a price of $1.00 per share. The initial closing occurred on April 16, 2018, and the Company issued 14,900,000 shares of Series A convertible preferred stock at a price per share of $1.00 for net cash proceeds of $14.7 million. In addition, a convertible note in the amount of $100,000 that was outstanding and automatically convertible in the Company’s next equity financing, converted into 100,000 shares of Series A convertible preferred stock upon the initial closing of the Series A financing. The investors also committed to purchase 15,000,000 and 30,000,000 shares of Series A convertible preferred stock at a price of $1.00 per share in second and third closings, respectively, contingent upon the achievement by the Company of certain development milestones and approval by the board of directors. The investors’ commitment to purchase and the Company’s commitment to sell shares of Series A convertible preferred stock represent a freestanding instrument accounted for at fair value and re-measured at each reporting date. For the three months ended March 31, 2020 and 2019, the Company recorded a gain of $0 and $437,000, respectively, for the revaluation of the convertible preferred stock liability within other income, net in the condensed consolidated statements of operations and comprehensive loss. In December 2018 and in June 2019, the Company and the Series A convertible preferred stockholders agreed to issue 9,000,000 and 20,000,000 shares of Series A convertible preferred stock at a price of $1.00 per share, respectively, related to the second and third closings. Aggregate net proceeds of $9.0 million were received in December 2018 and $20.0 million were received in June and July 2019. On October 25, 2019, the Company and the Series A preferred stockholders amended the Series A SPA, and the parties agreed that the Series A SPA would terminate upon consummation of the Company’s IPO. Upon the completion of the Company’s IPO on November 13, 2019, the remaining 16,000,000 shares of convertible preferred stock that were previously issuable under the third closing were no longer issuable. Accordingly, the preferred stock liability was extinguished and because the transaction occurred between related parties, the resulting $25.6 million was accounted for as a capital contribution by the preferred stockholders. Additionally, immediately prior to the completion of the Company’s IPO, all outstanding shares of convertible preferred stock automatically converted into 7,077,366 shares of common stock and the related carrying value was reclassified to common stock and additional paid-in capital. Accordingly, there were no shares of convertible preferred stock outstanding as of March 31, 2020 and December 31, 2019. |
Share-Based Compensation
Share-Based Compensation | 3 Months Ended |
Mar. 31, 2020 | |
Disclosure Of Compensation Related Costs Sharebased Payments [Abstract] | |
Share-Based Compensation | 7. Share-Based Compensation Equity Incentive Plans In 2018, the Company’s board of directors adopted the 89Bio Ltd. 2018 Equity Incentive Plan (the “2018 Plan”). In connection with the Reorganization, in September 2019, the Company’s board of directors approved the 2019 Equity Incentive Plan (the “2019 Plan”), which became effective on September 17, 2019. From and after the effective date of the 2019 Plan, the Company will no longer be making any future awards under the 2018 Plan. The Company initially reserved 2,844,193 shares of common stock for issuance under the 2019 Plan. In addition, the number of shares of common stock reserved for issuance under the 2019 Plan will automatically increase on the first day of January for a period of up to ten years, commencing on January 1, 2020, in an amount equal to 4% of the total number of shares of the Company’s capital stock outstanding on the immediately preceding December 31, or a lesser number of shares determined by the Company’s board of directors. As of March 31, 2020, there were 1,676,191 shares of common stock available for issuance as future option grants under the 2019 Plan. Employee Stock Purchase Plan (ESPP) In October 2019, the Company adopted the 2019 Employee Stock Purchase Plan (“ESPP”), which became effective following the date of the IPO. The Company initially reserved 225,188 shares of common stock for purchase under the ESPP. The number of shares of common stock reserved for issuance under the ESPP will automatically increase on the first day of January for a period of up to ten years, in an amount equal to 1% of the total number of shares of the Company’s common stock outstanding on the immediately preceding December 31, or a lesser number of shares determined by the Company’s board of directors. Purchases will be accomplished through the participation of discrete offering periods. Each offering will be no more than 27 months long. For each offering period, ESPP participants will purchase shares of common stock at a price per share equal to 85% of the lesser of the fair market value of the Company’s common stock on (1) the first trading day of the applicable offering period or (2) the last trading day of each purchase period the applicable offering period. The first six month offering period pursuant to the ESPP commenced on January 1, 2020. Total share-based compensation related to the ESPP for the three months ended March 31, 2020 was $13,000. As of March 31, 2020, 363,078 shares of common stock were available for issuance under the ESPP. The Company recorded share-based compensation for the periods indicated as follows (in thousands): Three Months Ended March 31, 2020 2019 Research and development $ 192 $ 7 General and administrative 301 28 Total share-based compensation $ 493 $ 35 The fair value of option awards granted for the periods indicated was estimated at the date of grant using a Black-Scholes option-pricing model with the following assumptions: Three Months Ended March 31, 2020 2019 Stock Options Expected term (years) 6.00-6.11 6.11 Expected volatility 86.4-87.5 % 61.8 % Risk-free interest rate 0.5-1.5 % 2.5-2.6 % Expected dividend — — The following table summarizes stock option activity for the three months ended March 31, 2020: Weighted Weighted Average Average Remaining Aggregate Number of Exercise Contractual Intrinsic Options Price Term Value (In years) (In thousands) Balance outstanding as of December 31, 2019 1,320,243 $ 3.34 9.23 $ 30,353 Granted 439,800 31.66 Exercised (4,876 ) 1.93 Cancelled (40,482 ) 2.87 Balance outstanding as of March 31, 2020 1,714,685 10.62 9.21 $ 28,115 Exercisable as of March 31, 2020 299,571 $ 2.00 8.69 $ 6,850 |
Net Loss Per Share
Net Loss Per Share | 3 Months Ended |
Mar. 31, 2020 | |
Earnings Per Share [Abstract] | |
Net Loss Per Share | 8. Net Loss Per Share Basic net loss per share is computed by dividing net loss by the weighted-average number of common shares outstanding for the period. Since the Company was in a loss position for all periods presented, diluted net loss per share is the same as basic net loss per share for all periods as the inclusion of all potential shares of common stock outstanding would have been anti-dilutive. The following outstanding potentially dilutive common stock equivalents have been excluded from the calculation of diluted net loss per share for the periods presented due to their anti-dilutive effect: Three Months Ended March 31, 2020 2019 Stock options to purchase common stock 1,714,685 734,569 Employee stock purchase plan 1,735 — Convertible preferred stock, as converted — 3,860,383 Total 1,716,420 4,594,952 |
Related Party Transactions
Related Party Transactions | 3 Months Ended |
Mar. 31, 2020 | |
Related Party Transactions [Abstract] | |
Related Party Transactions | 9. Related Party Transactions The Company incurred $4,000 and $33,000 in professional consulting services expense related to certain members of the board of directors for the three months ended March 31, 2020 and 2019, respectively, which is recorded within research and development expenses in the Company’s condensed consolidated statements of operations and comprehensive loss. The related party liability balance was $0 as of March 31, 2020 and $11,000 as of December 31, 2019, respectively, which is recorded within accounts payable and accrued expenses in the Company’s condensed consolidated balance sheets. The Company and the Series A preferred stockholders amended the Series A SPA on October 25, 2019, and the parties agreed that the Series A SPA would terminate upon consummation of the Company’s IPO. Upon the completion of the Company’s IPO on November 13, 2019, the remaining 16,000,000 shares of convertible preferred stock that were issuable were no longer issuable. Accordingly, the preferred stock liability was extinguished and because the transaction occurred between related parties, the resulting $25.6 million was accounted for as a capital contribution by the preferred stockholders and recorded as part of additional paid-in capital in the condensed consolidated balance sheets (see Note 6). |
Subsequent Event
Subsequent Event | 3 Months Ended |
Mar. 31, 2020 | |
Subsequent Events [Abstract] | |
Subsequent Event | 10. Subsequent Event On April 7, 2020, the Company and certain of its subsidiaries entered into a Loan and Security Agreement (the “Loan Agreement”) with the lenders referred to therein (the “Lenders”), and Silicon Valley Bank, as collateral agent. The Loan Agreement provides for (i) a secured term A loan facility (the “Term A Loan Facility”) of up to $10.0 million and (ii) a secured term B loan facility (the “Term B Loan Facility”) of up to $5.0 million that is available upon the Company satisfying certain milestones. The Term A Loan Facility matures on November 1, 2022; provided, that if the Term B Loan Facility is funded, the facilities instead mature on September 1, 2023. The loan will bear interest at the greater of (i) 4.50% and (ii) the sum of (a) the Prime Rate as reported in The Wall Street Journal plus (b) 1.25%. In addition, under the Loan Agreement, the Company agreed to issue the Lenders warrants to purchase shares of the Company’s common stock. On April 7, 2020, warrants to purchase 25,000 shares of the Company’s common stock were issued with a warrant exercise price of $22.06 per share. Additional warrants exercisable for 8,333 shares of common stock will be issued in connection with the Term B Loan Facility, if funded. |
Summary of Significant Accoun_2
Summary of Significant Accounting Policies (Policies) | 3 Months Ended |
Mar. 31, 2020 | |
Accounting Policies [Abstract] | |
Unaudited Condensed Consolidated Financial Statements | Unaudited Condensed Consolidated Financial Statements The accompanying interim unaudited condensed consolidated financial statements have been prepared in accordance with generally accepted accounting principles in the United States (“U.S. GAAP”) and applicable rules and regulations of the SEC regarding interim financial reporting. The accompanying interim condensed consolidated financial statements are unaudited. The interim unaudited condensed consolidated financial statements have been prepared on the same basis as the audited consolidated financial statements as of and for the year ended December 31, 2019 and, in the opinion of management, reflect all adjustments, which include only normal recurring adjustments, necessary to present fairly the Company’s consolidated financial position, results of operations and comprehensive loss, and cash flows. The results of operations for the three months ended March 31, 2020 are not necessarily indicative of the results to be expected for the year ending December 31, 2020 or for any other future annual or interim period. The condensed consolidated balance sheet as of December 31, 2019 was derived from the audited financial statements as of that date. These condensed consolidated financial statements should be read in conjunction with the Company’s audited consolidated financial statements included in the Annual Report on Form 10-K for the year ended December 31, 2019, which was filed with the SEC on March 18, 2020. |
Principles of Consolidation | Principles of Consolidation The accompanying condensed consolidated financial statements include the accounts of the Company and its wholly owned subsidiaries. All intercompany balances and transactions have been eliminated in consolidation. |
Use of Estimates | Use of Estimates The preparation of consolidated financial statements in conformity with U.S. GAAP requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities and disclosure of contingent assets and liabilities as of the date of the consolidated financial statements and the reported amounts of expenses during the reporting period. Significant estimates and assumptions made in the accompanying condensed consolidated financial statements include but are not limited to the fair value of stock options, the convertible preferred stock liability and certain accruals. The Company evaluates its estimates and assumptions on an ongoing basis using historical experience and other factors and adjusts those estimates and assumptions when facts and circumstances dictate. Actual results could differ from those estimates. |
Fair Value Measurements | Fair Value Measurements Financial assets and liabilities are recorded at fair value on a recurring basis in the balance sheets. The carrying values of Company’s financial assets and liabilities, including cash and cash equivalents, restricted cash, prepaid and other current assets, accounts payable, and accrued expenses approximate their fair values due to the short-term maturity of these instruments. Fair value is defined as the price that would be received to sell an asset or paid to transfer a liability (an exit price) in an orderly transaction between market participants at the reporting date. Assets and liabilities recorded at fair value are categorized based upon the level of judgment associated with the inputs used to measure their fair value. Hierarchical levels are directly related to the amount of subjectivity with the inputs to the valuation of these assets or liabilities as follows: Level 1 —Observable inputs such as unadjusted, quoted prices in active markets for identical assets or liabilities at the measurement date; Level 2 —Inputs (other than quoted prices included in Level 1) are either directly or indirectly observable inputs for similar assets or liabilities. These include quoted prices for identical or similar assets or liabilities in active markets and quoted prices for identical or similar assets or liabilities in markets that are not active; Level 3 —Unobservable inputs that are supported by little or no market activity and that are significant to the fair value of the assets or liabilities. |
Convertible Preferred Stock Liability | Convertible Preferred Stock Liability The freestanding instruments related to the commitment by the Series A convertible preferred stockholders to purchase and by the Company to sell its Series A convertible preferred stock in subsequent closings, contingent upon the achievement of certain developmental milestones and approval by the board of directors, at a fixed price per stock, were considered a liability (or an asset), measured at fair value as the shares underlying the rights contained liquidation preferences upon certain “deemed liquidation events” that were not solely within the Company’s control and which were considered in-substance contingent redemption features. The instruments were subject to revaluation at each balance sheet date until settlement or extinguishment, with revaluations recognized as either a component of other income, net in the condensed consolidated statements of operations and comprehensive loss, or additional paid-in capital in the condensed consolidated balance sheets. Upon the completion of the Company’s IPO, the remaining shares of convertible preferred stock that were previously issuable under the third closing were no longer issuable. Accordingly, the preferred stock liability was extinguished and because the transaction occurred between related parties, the resulting $25.6 million was accounted for as a capital contribution by the preferred stockholders. |
Risk and Uncertainties | Risk and Uncertainties In December 2019, a novel strain of coronavirus, SARS-CoV-2, causing a disease referred to as COVID-19, was reported to have surfaced in Wuhan, China. Since then, COVID-19 has spread to other countries, including the United States, and has been declared a pandemic by the World Health Organization. If COVID-19 continues to spread in the United States and worldwide, the Company may experience disruptions that could negatively impact its ability to recruit and onboard new employees and productivity, disrupt the business and delay preclinical and clinical programs and timelines, the magnitude of which will depend, in part, on the length and severity of restrictions and limitations on the Company’s ability to conduct business in the ordinary course. At this point, the extent to which COVID-19 may impact the Company’s operating results and financial condition is uncertain. |
Recently Adopted Accounting Pronouncement | Recently Adopted Accounting Pronouncement In August 2018, the FASB issued ASU No. 2018-13, Disclosure Framework – Changes to the Disclosure Requirements for Fair Value Measurement |
Recent Accounting Pronouncements | Recent Accounting Pronouncements In February 2016, the FASB issued ASU 2016-02— Leases In December 2019, the FASB issued ASU 2019-12, Income Taxes (Topic 740): Simplifying the Accounting for Income Taxes |
Fair Value Measurements (Tables
Fair Value Measurements (Tables) | 3 Months Ended |
Mar. 31, 2020 | |
Fair Value Disclosures [Abstract] | |
Summary of Changes in Fair Value of Level 3 Liability | For the three months ended March 31, 2019, changes in the fair value of the Company’s Level 3 financial liability were measured on a recurring basis as follows (in thousands): Three Months Ended March 31, 2019 Beginning balance $ 1,671 Revaluation of convertible preferred stock liability recorded in other income, net (437 ) Ending balance $ 1,234 |
Summary of Fair Value Assumptions | The Company estimated the fair value of this commitment using the Black-Scholes option-pricing model using the following assumptions: Three Months Ended March 31, 2019 Stock price $ 0.99 Exercise price $ 1.00 Expected term (years) 0.24-2.25 Expected volatility 72.0 % Risk-free interest rate 2.3-2.4 % |
Consolidated Balance Sheet Co_2
Consolidated Balance Sheet Components (Tables) | 3 Months Ended |
Mar. 31, 2020 | |
Balance Sheet Related Disclosures [Abstract] | |
Schedule of Accrued Expenses | Accrued expenses consist of the following (in thousands): March 31, December 31, 2020 2019 Accrued research and development expense $ 2,169 $ 2,326 Accrued employee and related expenses 730 1,396 Accrued professional and legal fees 552 573 Accrued other 281 325 Total accrued expenses $ 3,732 $ 4,620 |
Commitments and Contingencies (
Commitments and Contingencies (Tables) | 3 Months Ended |
Mar. 31, 2020 | |
Commitments And Contingencies Disclosure [Abstract] | |
Schedule of Future Minimum Lease Payments Under Non-cancellable Operating Lease Obligations | Future minimum Remainder of 2020 $ 161 2021 216 2022 8 Total future minimum annual payments $ 385 |
Share-Based Compensation (Table
Share-Based Compensation (Tables) | 3 Months Ended |
Mar. 31, 2020 | |
Disclosure Of Compensation Related Costs Sharebased Payments [Abstract] | |
Summary of Share-Based Compensation | The Company recorded share-based compensation for the periods indicated as follows (in thousands): Three Months Ended March 31, 2020 2019 Research and development $ 192 $ 7 General and administrative 301 28 Total share-based compensation $ 493 $ 35 |
Summary of Estimated Fair Value of Option Awards Granted Using Black-Scholes Option-Pricing Model | The fair value of option awards granted for the periods indicated was estimated at the date of grant using a Black-Scholes option-pricing model with the following assumptions: Three Months Ended March 31, 2020 2019 Stock Options Expected term (years) 6.00-6.11 6.11 Expected volatility 86.4-87.5 % 61.8 % Risk-free interest rate 0.5-1.5 % 2.5-2.6 % Expected dividend — — |
Summary of Stock Option Activity | The following table summarizes stock option activity for the three months ended March 31, 2020: Weighted Weighted Average Average Remaining Aggregate Number of Exercise Contractual Intrinsic Options Price Term Value (In years) (In thousands) Balance outstanding as of December 31, 2019 1,320,243 $ 3.34 9.23 $ 30,353 Granted 439,800 31.66 Exercised (4,876 ) 1.93 Cancelled (40,482 ) 2.87 Balance outstanding as of March 31, 2020 1,714,685 10.62 9.21 $ 28,115 Exercisable as of March 31, 2020 299,571 $ 2.00 8.69 $ 6,850 |
Net Loss Per Share (Tables)
Net Loss Per Share (Tables) | 3 Months Ended |
Mar. 31, 2020 | |
Earnings Per Share [Abstract] | |
Schedule of Outstanding Potentially Dilutive Securities Excluded From Calculation of Diluted Net Loss | The following outstanding potentially dilutive common stock equivalents have been excluded from the calculation of diluted net loss per share for the periods presented due to their anti-dilutive effect: Three Months Ended March 31, 2020 2019 Stock options to purchase common stock 1,714,685 734,569 Employee stock purchase plan 1,735 — Convertible preferred stock, as converted — 3,860,383 Total 1,716,420 4,594,952 |
Organization and Basis of Pre_2
Organization and Basis of Presentation - Additional Information (Details) $ / shares in Units, $ in Thousands | Nov. 13, 2019USD ($)$ / sharesshares | Mar. 31, 2020USD ($) | Dec. 31, 2019USD ($) | Mar. 31, 2019USD ($) |
Subsidiary Sale Of Stock [Line Items] | ||||
Date of incorporation | Jun. 28, 2019 | |||
Reorganization exchange of equity percentage of ordinary shares exchanged | 100.00% | |||
Reorganization exchange of equity percentage of common stock issued upon exchange | 100.00% | |||
Reverse stock split conversion ratio | 0.160849 | |||
Cash and cash equivalents | $ 85,532 | $ 93,335 | $ 7,064 | |
Common Stock | ||||
Subsidiary Sale Of Stock [Line Items] | ||||
Convertible preferred stock automatically converted into common stock | shares | 7,077,366 | |||
IPO | Common Stock | ||||
Subsidiary Sale Of Stock [Line Items] | ||||
Shares issued and sold | shares | 6,100,390 | |||
IPO price per share | $ / shares | $ 16 | |||
Proceeds from issuance of common stock, net of underwriters discount and commissions | $ 87,700 | |||
Payment of underwriting discounts, commissions | 6,800 | |||
Other offering expenses | $ 3,100 | |||
Underwriters option | Common Stock | ||||
Subsidiary Sale Of Stock [Line Items] | ||||
Shares issued and sold | shares | 795,703 |
Summary of Significant Accoun_3
Summary of Significant Accounting Policies - Additional Information (Details) $ in Millions | Nov. 13, 2019USD ($) |
Accounting Policies [Abstract] | |
Capital contribution related to extinguishment of preferred stock liability | $ 25.6 |
Fair Value Measurements - Addit
Fair Value Measurements - Additional Information (Details) | Mar. 31, 2020USD ($) |
Level 3 | |
Fair Value Liabilities Measured On Recurring Basis Unobservable Input Reconciliation [Line Items] | |
Fair value measurement, financial liability | $ 0 |
Fair Value Measurements - Summa
Fair Value Measurements - Summary of Changes in Fair Value of Level 3 Liability (Details) - Recurring - Level 3 $ in Thousands | 3 Months Ended |
Mar. 31, 2019USD ($) | |
Fair Value Liabilities Measured On Recurring Basis Unobservable Input Reconciliation [Line Items] | |
Beginning balance | $ 1,671 |
Revaluation of convertible preferred stock liability recorded in other income, net | (437) |
Ending balance | $ 1,234 |
Fair Value Measurements - Sum_2
Fair Value Measurements - Summary of Fair Value Assumptions (Details) - Convertible Preferred Stock Liability - Black Scholes Option Pricing Model | 3 Months Ended |
Mar. 31, 2019$ / shares | |
Stock Price | |
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis Valuation Techniques [Line Items] | |
Fair Measurement Input | 0.99 |
Exercise Price | |
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis Valuation Techniques [Line Items] | |
Fair Measurement Input | 1 |
Expected Term (Years) | Minimum | |
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis Valuation Techniques [Line Items] | |
Fair Measurement Input | 2 months 26 days |
Expected Term (Years) | Maximum | |
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis Valuation Techniques [Line Items] | |
Fair Measurement Input | 2 years 3 months |
Expected Volatility | |
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis Valuation Techniques [Line Items] | |
Fair Measurement Input | 72 |
Risk-free Interest Rate | Minimum | |
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis Valuation Techniques [Line Items] | |
Fair Measurement Input | 2.3 |
Risk-free Interest Rate | Maximum | |
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis Valuation Techniques [Line Items] | |
Fair Measurement Input | 2.4 |
Consolidated Balance Sheet Co_3
Consolidated Balance Sheet Components - Schedule of Accrued Expenses (Details) - USD ($) $ in Thousands | Mar. 31, 2020 | Dec. 31, 2019 |
Payables And Accruals [Abstract] | ||
Accrued research and development expense | $ 2,169 | $ 2,326 |
Accrued employee and related expenses | 730 | 1,396 |
Accrued professional and legal fees | 552 | 573 |
Accrued other | 281 | 325 |
Total accrued expenses | $ 3,732 | $ 4,620 |
Commitments and Contingencies -
Commitments and Contingencies - Schedule of Future Minimum Lease Payments Under Non-cancellable Operating Lease Obligations (Details) $ in Thousands | Mar. 31, 2020USD ($) |
Commitments And Contingencies Disclosure [Abstract] | |
Remainder of 2020 | $ 161 |
2021 | 216 |
2022 | 8 |
Total future minimum annual payments | $ 385 |
Commitments and Contingencies_2
Commitments and Contingencies - Additional Information (Details) - USD ($) | 1 Months Ended | 3 Months Ended | |
Apr. 30, 2018 | Mar. 31, 2020 | Mar. 31, 2019 | |
Loss Contingencies [Line Items] | |||
Operating leases, rent expense | $ 60,000 | $ 27,000 | |
Teva Agreements | |||
Loss Contingencies [Line Items] | |||
Nonrefundable upfront payment | $ 6,000,000 | ||
Payment upon achievement of certain clinical and commercial milestones | 135,000,000 | ||
Asset transfer and license agreement, termination period after written notice | 120 days | ||
Asset transfer and license agreement, termination period notice of breach | 60 days | ||
Asset transfer and license agreement termination notice period if bankruptcy petition filed | 60 days | ||
Teva Agreements | Research and Development Expenses | |||
Loss Contingencies [Line Items] | |||
Up-front license payment | $ 0 | $ 0 | |
Teva Agreements | Teva’s GlycoPEGylated FGF21 Program | |||
Loss Contingencies [Line Items] | |||
Payment upon achievement of certain clinical and commercial milestones | 67,500,000 | ||
Teva Agreements | Teva’s Development Program | |||
Loss Contingencies [Line Items] | |||
Payment upon achievement of certain clinical and commercial milestones | $ 67,500,000 |
Convertible Preferred Stock - A
Convertible Preferred Stock - Additional Information (Details) - USD ($) | Nov. 13, 2019 | Apr. 16, 2018 | Dec. 31, 2018 | Jul. 31, 2019 | Mar. 31, 2020 | Mar. 31, 2019 | Dec. 31, 2019 | Jun. 30, 2019 | Apr. 30, 2018 |
Temporary Equity [Line Items] | |||||||||
Capital contribution related to extinguishment of preferred stock liability | $ 25,600,000 | ||||||||
Convertible preferred stock outstanding | 0 | 0 | |||||||
Common Stock | |||||||||
Temporary Equity [Line Items] | |||||||||
Convertible preferred stock automatically converted into common stock | 7,077,366 | ||||||||
Series A Convertible Preferred Stock | |||||||||
Temporary Equity [Line Items] | |||||||||
Number of shares committed to purchase, no longer issuable | 16,000,000 | ||||||||
Series A Share Purchase Agreement | |||||||||
Temporary Equity [Line Items] | |||||||||
Convertible note outstanding amount converted into shares | 100,000 | ||||||||
Series A Share Purchase Agreement | Series A Convertible Preferred Stock | |||||||||
Temporary Equity [Line Items] | |||||||||
Per share price of issuance of shares | $ 1 | ||||||||
Convertible note outstanding amount converted into shares | 100,000 | ||||||||
Series A Share Purchase Agreement | Series A Convertible Preferred Stock | Other Income, Net | |||||||||
Temporary Equity [Line Items] | |||||||||
Gain recorded for revaluation of convertible preferred stock liability | $ 0 | $ 437,000 | |||||||
Series A Share Purchase Agreement | Series A Convertible Preferred Stock | Initial Closing | |||||||||
Temporary Equity [Line Items] | |||||||||
Per share price of issuance of shares | $ 1 | ||||||||
Shares issued | 14,900,000 | ||||||||
Net cash proceeds | $ 14,700,000 | ||||||||
Series A Share Purchase Agreement | Series A Convertible Preferred Stock | Second Closing | |||||||||
Temporary Equity [Line Items] | |||||||||
Per share price of issuance of shares | $ 1 | $ 1 | |||||||
Shares issued | 9,000,000 | ||||||||
Net cash proceeds | $ 9,000,000 | ||||||||
Number of shares committed to purchase | 15,000,000 | ||||||||
Series A Share Purchase Agreement | Series A Convertible Preferred Stock | Third Closing | |||||||||
Temporary Equity [Line Items] | |||||||||
Per share price of issuance of shares | $ 1 | $ 1 | |||||||
Shares issued | 20,000,000 | ||||||||
Net cash proceeds | $ 20,000,000 | ||||||||
Number of shares committed to purchase | 30,000,000 | ||||||||
Series A Share Purchase Agreement | Series A Convertible Preferred Stock | Maximum | |||||||||
Temporary Equity [Line Items] | |||||||||
Total amount of preferred shares issuable by the entity | $ 60,000,000 |
Share-Based Compensation - Addi
Share-Based Compensation - Additional Information (Details) - USD ($) | 1 Months Ended | 3 Months Ended | ||
Oct. 31, 2019 | Sep. 30, 2019 | Mar. 31, 2020 | Mar. 31, 2019 | |
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] | ||||
Total share-based compensation | $ 493,000 | $ 35,000 | ||
Employee Stock Purchase Plan | ||||
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] | ||||
Number of common shares issuable under the plan (in shares) | 225,188 | |||
Percentage of increase in number of shares of capital stock issued and outstanding | 1.00% | |||
Percent of purchase shares of common stock | 85.00% | |||
First offering period | 6 months | |||
Commencement date of first six month offering period | Jan. 1, 2020 | |||
Total share-based compensation | $ 13,000 | |||
Number of shares of common stock available for issuance under ESPP | 363,078 | |||
2019 Plan | ||||
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] | ||||
Number of common shares issuable under the plan (in shares) | 2,844,193 | |||
Percentage of increase in number of shares of capital stock issued and outstanding | 4.00% | |||
Common stock reserved and available for issuance as future option grants | 1,676,191 | |||
Maximum | Employee Stock Purchase Plan | ||||
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] | ||||
Period for increase in number of shares of common stock reserved for issuance | 10 years | |||
Maximum | 2019 Plan | ||||
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] | ||||
Period for increase in number of shares of common stock reserved for issuance | 10 years |
Share-Based Compensation - Summ
Share-Based Compensation - Summary of Share-Based Compensation (Details) - USD ($) $ in Thousands | 3 Months Ended | |
Mar. 31, 2020 | Mar. 31, 2019 | |
Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Line Items] | ||
Share-based compensation | $ 493 | $ 35 |
Research and Development | ||
Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Line Items] | ||
Share-based compensation | 192 | 7 |
General and Administrative | ||
Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Line Items] | ||
Share-based compensation | $ 301 | $ 28 |
Share-Based Compensation - Su_2
Share-Based Compensation - Summary of Estimated Fair Value of Option Awards Granted Using Black-Scholes Option-Pricing Model (Details) - Stock Options | 3 Months Ended | |
Mar. 31, 2020 | Mar. 31, 2019 | |
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] | ||
Expected term (years) | 6 years 1 month 9 days | |
Expected volatility, minimum | 86.40% | |
Expected volatility, maximum | 87.50% | |
Risk-free interest rate, minimum | 0.50% | 2.50% |
Risk-free interest rate, maximum | 1.50% | 2.60% |
Expected volatility | 61.80% | |
Minimum | ||
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] | ||
Expected term (years) | 6 years | |
Maximum | ||
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] | ||
Expected term (years) | 6 years 1 month 9 days |
Share-Based Compensation - Su_3
Share-Based Compensation - Summary of Stock Option Activity (Details) - USD ($) $ / shares in Units, $ in Thousands | 3 Months Ended | 12 Months Ended |
Mar. 31, 2020 | Dec. 31, 2019 | |
Number of Options | ||
Outstanding, Beginning Balance | 1,320,243 | |
Granted | 439,800 | |
Exercised | (4,876) | |
Cancelled | (40,482) | |
Outstanding, Ending Balance | 1,714,685 | 1,320,243 |
Exercisable as of March 31, 2020 | 299,571 | |
Weighted Average Exercise Price | ||
Weighted Average Exercise Price Outstanding, Beginning Balance | $ 3.34 | |
Weighted Average Exercise Price, Granted | 31.66 | |
Weighted Average Exercise Price, Exercised | 1.93 | |
Weighted Average Exercise Price, Cancelled | 2.87 | |
Weighted Average Exercise Price Outstanding, Ending Balance | 10.62 | $ 3.34 |
Weighted Average Exercise Price, Exercisable as of March 31, 2020 | $ 2 | |
Weighted Average Remaining Contractual Term (In years) | ||
Weighted Average Remaining Contractual Term (In years), Outstanding | 9 years 2 months 15 days | 9 years 2 months 23 days |
Weighted Average Remaining Contractual Term (In years), Exercisable as of March 31, 2020 | 8 years 8 months 8 days | |
Aggregate Intrinsic Value | ||
Aggregate Intrinsic Value Outstanding | $ 28,115 | $ 30,353 |
Aggregate Intrinsic Value, Exercisable as of March 31, 2020 | $ 6,850 |
Net Loss Per Share - Schedule o
Net Loss Per Share - Schedule of Outstanding Potentially Dilutive Securities Excluded From Calculation of Diluted Net Loss (Details) - shares | 3 Months Ended | |
Mar. 31, 2020 | Mar. 31, 2019 | |
Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items] | ||
Antidilutive common stock equivalents excluded from calculation of diluted net loss per share | 1,716,420 | 4,594,952 |
Stock Options to Purchase Common Stock | ||
Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items] | ||
Antidilutive common stock equivalents excluded from calculation of diluted net loss per share | 1,714,685 | 734,569 |
Convertible Preferred Stock, as Converted | ||
Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items] | ||
Antidilutive common stock equivalents excluded from calculation of diluted net loss per share | 3,860,383 | |
Employee Stock Purchase Plan | ||
Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items] | ||
Antidilutive common stock equivalents excluded from calculation of diluted net loss per share | 1,735 |
Related Party Transactions - Ad
Related Party Transactions - Additional Information (Details) - USD ($) | Nov. 13, 2019 | Mar. 31, 2020 | Mar. 31, 2019 | Dec. 31, 2019 |
Related Party Transaction [Line Items] | ||||
Outstanding liability to related party | $ 0 | $ 11,000 | ||
Capital contribution | $ 25,600,000 | |||
Series A Convertible Preferred Stock | ||||
Related Party Transaction [Line Items] | ||||
Number of shares committed to purchase, no longer issuable | 16,000,000 | |||
Additional Paid-in Capital | ||||
Related Party Transaction [Line Items] | ||||
Capital contribution | $ 25,600,000 | |||
Board of Directors | ||||
Related Party Transaction [Line Items] | ||||
Professional services expense | $ 4,000 | $ 33,000 |
Subsequent Event - Additional I
Subsequent Event - Additional Information (Details) - Loan Agreement - Subsequent Event | Apr. 07, 2020USD ($)$ / sharesshares |
Subsequent Event [Line Items] | |
Credit facility maturity date | Sep. 1, 2023 |
Line of credit facility, description | On April 7, 2020, the Company and certain of its subsidiaries entered into a Loan and Security Agreement (the “Loan Agreement”) with the lenders referred to therein (the “Lenders”), and Silicon Valley Bank, as collateral agent. The Loan Agreement provides for (i) a secured term A loan facility (the “Term A Loan Facility”) of up to $10.0 million and (ii) a secured term B loan facility (the “Term B Loan Facility”) of up to $5.0 million that is available upon the Company satisfying certain milestones. The Term A Loan Facility matures on November 1, 2022; provided, that if the Term B Loan Facility is funded, the facilities instead mature on September 1, 2023. The loan will bear interest at the greater of (i) 4.50% and (ii) the sum of (a) the Prime Rate as reported in The Wall Street Journal plus (b) 1.25%. |
Prime Rate | |
Subsequent Event [Line Items] | |
Debt instrument, basis spread on variable rate | 1.25% |
Minimum | |
Subsequent Event [Line Items] | |
Debt instrument, interest rate | 4.50% |
Term A Loan Facility | |
Subsequent Event [Line Items] | |
Line of credit facility, maximum borrowing capacity | $ | $ 10,000,000 |
Credit facility maturity date | Nov. 1, 2022 |
Warrants to purchase common stock | shares | 25,000 |
Warrant exercise price | $ / shares | $ 22.06 |
Term B Loan Facility | |
Subsequent Event [Line Items] | |
Line of credit facility, maximum borrowing capacity | $ | $ 5,000,000 |
Warrants to purchase common stock | shares | 8,333 |