Fresh2 (FRES) 20-F/A 2022 FY Annual report (foreign) (amended)

Exhibit 16.1

March 25, 2024

Securities and Exchange Commission

100 F Street, N.E.

Washington, DC 20549

Commissioners:

We have read the statements made by Fresh2 Group Limited (formerly known as AnPac Bio-Medical Science Co., Ltd.) under Item 16F of its Amendment No. 2 to Form 20-F dated March 22, 2024. We agree with the statements concerning our Firm in such Amendment No. 2 to Form 20-F; we are not in a position to agree or disagree with other statements of Fresh2 Group Limited contained therein.

Very truly yours,

/s/ Friedman LLP

New York, New York