Avidity Partners Management 13F-HR Quarterly holdings report by institutional manager

The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

OMB APPROVAL

OMB Number:		3235-0006
Expires:	Oct 31, 2018
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COLUMN 1	COLUMN 2	COLUMN 3	COLUMN 4	COLUMN 5			COLUMN 6	COLUMN 7	COLUMN 8
			VALUE	SHRS OR	SH/	PUT/	INVESTMENT	OTHER	VOTING AUTHORITY
NAME OF ISSUER	TITLE OF CLASS	CUSIP	(x$1000)	PRN AMT	PRN	CALL	DISCRETION	MANAGER	SOLE	SHARED	NONE
ABBVIE INC	COM	00287Y109	41,336,700	227,000	SH		SOLE		227,000	0	0
AC IMMUNE SA	SHS	H00263105	13,231,200	4,470,000	SH		SOLE		4,470,000	0	0
ACADIA HEALTHCARE COMPANY IN	COM	00404A109	79,616,100	1,005,000	SH		SOLE		1,005,000	0	0
ACADIA PHARMACEUTICALS INC	COM	004225108	10,881,365	588,500	SH		SOLE		588,500	0	0
ALIGN TECHNOLOGY INC	COM	016255101	61,976,880	189,000	SH		SOLE		189,000	0	0
ALNYLAM PHARMACEUTICALS INC	COM	02043Q107	36,316,350	243,000	SH		SOLE		243,000	0	0
ALPINE IMMUNE SCIENCES INC	COM	02083G100	46,565,108	1,174,700	SH		SOLE		1,174,700	0	0
AN2 THERAPEUTICS INC	COM	037326105	3,737,500	1,150,000	SH		SOLE		1,150,000	0	0
APOGEE THERAPEUTICS INC	COM	03770N101	25,576,140	384,893	SH		SOLE		384,893	0	0
ARVINAS INC	COM	04335A105	123,228,643	2,985,190	SH		SOLE		2,985,190	0	0
ASTRAZENECA PLC	SPONSORED ADR	046353108	10,840,000	160,000	SH		SOLE		160,000	0	0
ASTRIA THERAPEUTICS INC	COM	04635X102	13,821,650	982,000	SH		SOLE		982,000	0	0
AVANTOR INC	COM	05352A100	68,911,150	2,695,000	SH		SOLE		2,695,000	0	0
AXSOME THERAPEUTICS INC	COM	05464T104	34,393,800	431,000	SH		SOLE		431,000	0	0
BIOHAVEN LTD	COM	G1110E107	4,101,750	75,000	SH		SOLE		75,000	0	0
BLUEPRINT MEDICINES CORP	COM	09627Y109	40,410,360	426,000	SH		SOLE		426,000	0	0
BOSTON SCIENTIFIC CORP	COM	101137107	133,966,440	1,956,000	SH		SOLE		1,956,000	0	0
CAREMAX INC	CL A NEW	14171W202	102,184	21,200	SH		SOLE		21,200	0	0
CARIBOU BIOSCIENCES INC	COM	142038108	29,736,709	5,785,352	SH		SOLE		5,785,352	0	0
CENTURY THERAPEUTICS INC	COM	15673T100	5,106,100	1,221,555	SH		SOLE		1,221,555	0	0
CG ONCOLOGY INC	COM	156944100	63,864,184	1,454,765	SH		SOLE		1,454,765	0	0
COGENT BIOSCIENCES INC	COM	19240Q201	2,995,144	445,706	SH		SOLE		445,706	0	0
COLLEGIUM PHARMACEUTICAL INC	COM	19459J104	14,029,548	361,400	SH		SOLE		361,400	0	0
CVS HEALTH CORP	COM	126650100	43,469,200	545,000	SH		SOLE		545,000	0	0
CYBIN INC	COM	23256X100	14,424,534	34,884,000	SH		SOLE		34,884,000	0	0
CYTOKINETICS INC	COM NEW	23282W605	11,638,260	166,000	SH		SOLE		166,000	0	0
CYTOKINETICS INC	COM NEW	23282W605	42,066,000	600,000	SH	Call	SOLE		600,000	0	0
DANAHER CORPORATION	COM	235851102	35,909,736	143,800	SH		SOLE		143,800	0	0
DEXCOM INC	COM	252131107	24,536,030	176,900	SH		SOLE		176,900	0	0
DIANTHUS THERAPEUTICS INC	COM	252828108	81,526,620	2,717,554	SH		SOLE		2,717,554	0	0
ELI LILLY & CO	COM	532457108	54,457,200	70,000	SH		SOLE		70,000	0	0
EMERGENT BIOSOLUTIONS INC	COM	29089Q105	4,827,240	1,908,000	SH		SOLE		1,908,000	0	0
ESTABLISHMENT LABS HLDGS INC	COM	G31249108	11,452,500	225,000	SH		SOLE		225,000	0	0
FUSION PHARMACEUTICALS INC	COM	36118A100	138,586,993	6,500,328	SH		SOLE		6,500,328	0	0
GINKGO BIOWORKS HOLDINGS INC	CL A SHS	37611X100	3,480,000	3,000,000	SH		SOLE		3,000,000	0	0
GLAUKOS CORP	COM	377322102	21,120,960	224,000	SH		SOLE		224,000	0	0
HYPERFINE INC	COM CL A	44916K106	1,188,178	1,188,178	SH		SOLE		1,188,178	0	0
IDEAYA BIOSCIENCES INC	COM	45166A102	35,090,836	799,700	SH		SOLE		799,700	0	0
ILLUMINA INC	COM	452327109	63,730,212	464,100	SH		SOLE		464,100	0	0
IMMUNIC INC	COM	4525EP101	11,751,923	8,902,972	SH		SOLE		8,902,972	0	0
IMMUNOCORE HLDGS PLC	ADS	45258D105	18,616,000	286,400	SH		SOLE		286,400	0	0
IMMUNOME INC	COM	45257U108	21,567,630	873,891	SH		SOLE		873,891	0	0
IMMUNOVANT INC	COM	45258J102	16,316,550	505,000	SH		SOLE		505,000	0	0
INTRA-CELLULAR THERAPIES INC	COM	46116X101	41,520,000	600,000	SH		SOLE		600,000	0	0
INTRA-CELLULAR THERAPIES INC	COM	46116X101	239,454,000	600,000	SH	Call	SOLE		600,000	0	0
INTUITIVE SURGICAL INC	COM NEW	46120E602	90,194,340	226,000	SH		SOLE		226,000	0	0
IONIS PHARMACEUTICALS INC	COM	462222100	5,635,500	130,000	SH		SOLE		130,000	0	0
JANUX THERAPEUTICS INC	COM	47103J105	14,466,824	384,245	SH		SOLE		384,245	0	0
JASPER THERAPEUTICS INC	COM NEW	471871202	22,313,600	760,000	SH		SOLE		760,000	0	0
JAZZ PHARMACEUTICALS PLC	SHS USD	G50871105	70,325,280	584,000	SH		SOLE		584,000	0	0
KARYOPHARM THERAPEUTICS INC	COM	48576U106	12,530,841	8,298,570	SH		SOLE		8,298,570	0	0
KEROS THERAPEUTICS INC	COM	492327101	13,882,140	209,700	SH		SOLE		209,700	0	0
KEZAR LIFE SCIENCES INC	COM	49372L100	4,531,442	5,026,000	SH		SOLE		5,026,000	0	0
KODIAK SCIENCES INC	COM	50015M109	1,578,000	300,000	SH		SOLE		300,000	0	0
KYVERNA THERAPEUTICS INC	COM	501976104	5,025,952	202,333	SH		SOLE		202,333	0	0
LANTHEUS HLDGS INC	COM	516544103	29,875,200	480,000	SH		SOLE		480,000	0	0
LEGEND BIOTECH CORP	SPONSORED ADS	52490G102	37,484,947	668,300	SH		SOLE		668,300	0	0
MCKESSON CORP	COM	58155Q103	17,877,105	33,300	SH		SOLE		33,300	0	0
MERCK & CO INC	COM	58933Y105	66,238,900	502,000	SH		SOLE		502,000	0	0
MIRUM PHARMACEUTICALS INC	COM	604749101	28,708,392	1,142,850	SH		SOLE		1,142,850	0	0
NATERA INC	COM	632307104	73,469,818	803,300	SH		SOLE		803,300	0	0
NEUMORA THERAPEUTICS INC.	COM	640979100	24,750,000	1,800,000	SH		SOLE		1,800,000	0	0
NEUROCRINE BIOSCIENCES INC	COM	64125C109	73,994,080	536,500	SH		SOLE		536,500	0	0
NEUROGENE INC	COM	64135M105	23,680,563	465,237	SH		SOLE		465,237	0	0
NEWAMSTERDAM PHARMA COMPANY	ORDINARY SHARES	N62509109	11,233,750	475,000	SH		SOLE		475,000	0	0
NUVATION BIO INC	*W EXP 07/07/202	67080N119	27,087	89,543	SH		SOLE		89,543	0	0
PACIFIC BIOSCIENCES CALIF IN	COM	69404D108	2,531,250	675,000	SH		SOLE		675,000	0	0
PHATHOM PHARMACEUTICALS INC	COM	71722W107	18,425,700	1,735,000	SH		SOLE		1,735,000	0	0
PRIME MEDICINE INC	COM	74168J101	13,930,000	1,990,000	SH		SOLE		1,990,000	0	0
PRIVIA HEALTH GROUP INC	COM	74276R102	14,970,678	764,200	SH		SOLE		764,200	0	0
RADNET INC	COM	750491102	11,581,080	238,000	SH		SOLE		238,000	0	0
REGENERON PHARMACEUTICALS	COM	75886F107	65,449,320	68,000	SH		SOLE		68,000	0	0
REGENXBIO INC	COM	75901B107	27,392,348	1,300,064	SH		SOLE		1,300,064	0	0
REVOLUTION MEDICINES INC	COM	76155X100	20,466,050	635,000	SH		SOLE		635,000	0	0
ROCKET PHARMACEUTICALS INC	COM	77313F106	27,613,500	1,025,000	SH		SOLE		1,025,000	0	0
SCYNEXIS INC	COM NEW	811292200	2,129,630	1,448,728	SH		SOLE		1,448,728	0	0
STRUCTURE THERAPEUTICS INC	SPONSORED ADS	86366E106	37,031,040	864,000	SH		SOLE		864,000	0	0
STRUCTURE THERAPEUTICS INC	SPONSORED ADS	86366E106	6,429,000	150,000	SH	Call	SOLE		150,000	0	0
SURGERY PARTNERS INC	COM	86881A100	43,104,350	1,445,000	SH		SOLE		1,445,000	0	0
SYNDAX PHARMACEUTICALS INC	COM	87164F105	57,417,500	2,412,500	SH		SOLE		2,412,500	0	0
SYROS PHARMACEUTICALS INC	COM NEW	87184Q206	8,953,428	1,673,538	SH		SOLE		1,673,538	0	0
TENET HEALTHCARE CORP	COM NEW	88033G407	63,171,110	601,000	SH		SOLE		601,000	0	0
THE CIGNA GROUP	COM	125523100	67,008,555	184,500	SH		SOLE		184,500	0	0
THERMO FISHER SCIENTIFIC INC	COM	883556102	21,272,286	36,600	SH		SOLE		36,600	0	0
ULTRAGENYX PHARMACEUTICAL IN	COM	90400D108	43,585,115	933,500	SH		SOLE		933,500	0	0
UNITED THERAPEUTICS CORP DEL	COM	91307C102	49,849,240	217,000	SH		SOLE		217,000	0	0
VAXCYTE INC	COM	92243G108	19,400,040	284,000	SH		SOLE		284,000	0	0
VERA THERAPEUTICS INC	CL A	92337R101	16,536,520	383,500	SH		SOLE		383,500	0	0
X4 PHARMACEUTICALS INC	COM	98420X103	3,354,070	2,413,000	SH		SOLE		2,413,000	0	0
XENON PHARMACEUTICALS INC	COM	98420N105	30,565,500	710,000	SH		SOLE		710,000	0	0