| Document and Entity Information | May 13, 2022 |
| Document and Entity Information [Abstract] | |
| Document Type | 8-K |
| Document Period End Date | May 13, 2022 |
| Entity Registrant Name | KIROMIC BIOPHARMA, INC. |
| Entity Incorporation, State or Country Code | DE |
| Entity File Number | 001-39619 |
| Entity Tax Identification Number | 46-4762913 |
| Entity Address, Address Line One | 7707 Fannin |
| Entity Address, Adress Line Two | Suite 140 |
| Entity Address, City or Town | Houston |
| Entity Address State Or Province | TX |
| Entity Address, Postal Zip Code | 77054 |
| City Area Code | 832 |
| Local Phone Number | 968-4888 |
| Written Communications | false |
| Soliciting Material | false |
| Pre-commencement Tender Offer | false |
| Pre-commencement Issuer Tender Offer | false |
| Title of 12(b) Security | Common Stock, $0.001 par value |
| Trading Symbol | KRBP |
| Security Exchange Name | NASDAQ |
| Entity Emerging Growth Company | true |
| Entity Ex Transition Period | false |
| Entity Central Index Key | 0001792581 |
| Amendment Flag | false |
