Aerovate Therapeutics (AVTE) 10-Q12 Aug 242024 Q2 Quarterly reportFinancial data

Company Profile

Cover

Cover - shares	6 Months Ended
Cover - shares	Jun. 30, 2024	Aug. 09, 2024
Cover [Abstract]
Document Type	10-Q
Document Quarterly Report	true
Document Period End Date	Jun. 30, 2024
Current Fiscal Year End Date	--12-31
Document Fiscal Year Focus	2024
Document Transition Report	false
Entity File Number	001-40544
Entity Registrant Name	AEROVATE THERAPEUTICS, INC.
Entity Incorporation, State or Country Code	DE
Entity Tax Identification Number	83-1377888
Entity Address, Address Line One	930 Winter Street
Entity Address, Address Line Two	Suite M-500
Entity Address, City or Town	Waltham
Entity Address, State or Province	MA
Entity Address, Postal Zip Code	02451
City Area Code	617
Local Phone Number	443-2400
Title of 12(b) Security	Common stock, par value $0.0001 per share
Trading Symbol	AVTE
Security Exchange Name	NASDAQ
Entity Current Reporting Status	Yes
Entity Interactive Data Current	Yes
Entity Filer Category	Non-accelerated Filer
Entity Small Business	true
Entity Emerging Growth Company	true
Elected Not To Use the Extended Transition Period	true
Entity Shell Company	false
Entity Common Stock, Shares Outstanding		28,867,711
Entity Central Index Key	0001798749
Document Fiscal Period Focus	Q2
Amendment Flag	false

Condensed Consolidated Balance

Condensed Consolidated Balance Sheets (Unaudited) - USD ($) $ in Thousands	Jun. 30, 2024	Dec. 31, 2023
Current assets:
Cash and cash equivalents	$ 31,069	$ 23,491
Short-term investments	73,133	98,948
Prepaid expenses and other current assets	6,558	1,793
Total current assets	110,760	124,232
Property and equipment, net	232	288
Operating lease right-of-use assets	621	614
Other long-term assets	81	2,284
Total assets	111,694	127,418
Current liabilities:
Accounts payable	4,179	2,396
Accrued and other current liabilities	12,366	14,821
Operating lease liabilities	475	420
Total current liabilities	17,020	17,637
Operating lease liabilities, net of current portion	206	255
Other liabilities	70	70
Total liabilities	17,296	17,962
Commitments and contingencies (Note 5)
Stockholders' equity:
Preferred stock, $0.0001 par value; 10,000,000 shares authorized as of June 30, 2024 and December 31, 2023, respectively; no shares issued and outstanding at June 30, 2024 and December 31, 2023, respectively
Common stock, $0.0001 par value; 150,000,000 shares authorized at June 30, 2024 and December 31, 2023, respectively; 28,854,750 and 27,762,703 shares issued and outstanding at June 30, 2024 and December 31, 2023, respectively	3	3
Additional paid-in capital	305,863	272,640
Accumulated other comprehensive (loss) income	(83)	237
Accumulated deficit	(211,385)	(163,424)
Total stockholders' equity	94,398	109,456
Total liabilities and stockholders' equity	$ 111,694	$ 127,418

Condensed Consolidated Balanc_2

Condensed Consolidated Balance Sheets (Unaudited) (Parenthetical) - $ / shares	Jun. 30, 2024	Dec. 31, 2023
Condensed Consolidated Balance Sheets (Unaudited)
Preferred stock, par value	$ 0.0001	$ 0.0001
Preferred stock, shares authorized	10,000,000	10,000,000
Preferred stock, shares issued	0	0
Preferred stock, shares outstanding	0	0
Common stock, par value	$ 0.0001	$ 0.0001
Common stock, shares authorized	150,000,000	150,000,000
Common stock, shares issued	28,854,750	27,762,703
Common stock, shares outstanding	28,854,750	27,762,703

Condensed Consolidated Statemen

Condensed Consolidated Statements of Operations and Comprehensive Loss (Unaudited) - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2024	Jun. 30, 2023	Jun. 30, 2024	Jun. 30, 2023
Operating expenses:
Research and development	$ 21,248	$ 16,034	$ 41,328	$ 29,522
General and administrative	4,917	4,302	9,455	8,453
Total operating expenses	26,165	20,336	50,783	37,975
Loss from operations	(26,165)	(20,336)	(50,783)	(37,975)
Other income (expense):
Interest income	1,396	1,312	2,831	2,432
Other expense:	(6)	(1)	(9)	(2)
Total other income	1,390	1,311	2,822	2,430
Net loss	(24,775)	(19,025)	(47,961)	(35,545)
Comprehensive loss:
Net loss	(24,775)	(19,025)	(47,961)	(35,545)
Other comprehensive loss:
Unrealized (loss) gain on securities	(50)	(22)	(320)	243
Comprehensive loss	$ (24,825)	$ (19,047)	$ (48,281)	$ (35,302)
Net loss per share, basic	$ (0.86)	$ (0.76)	$ (1.68)	$ (1.42)
Net loss per share, diluted	$ (0.86)	$ (0.76)	$ (1.68)	$ (1.42)
Weighted-average shares of common stock outstanding, basic	28,756,043	25,166,505	28,566,924	24,973,250
Weighted-average shares of common stock outstanding, diluted	28,756,043	25,166,505	28,566,924	24,973,250

Condensed Consolidated Statem_2

Condensed Consolidated Statements of Stockholders' Equity (Unaudited) - USD ($) $ in Thousands	Common Stock	Additional Paid-in Capital	Accumulated Other Comprehensive Gain/(Loss)	Accumulated Deficit	Total
Beginning balance, shares at Dec. 31, 2022	24,722,974
Beginning balance, value at Dec. 31, 2022	$ 2	$ 215,110	$ (466)	$ (87,903)	$ 126,743
Unrealized gain on investments			265		265
Issuance of common stock upon exercise of stock options		223			223
Issuance of common stock upon exercise of stock options (in shares)	93,966
Stock based compensation		2,384			2,384
Net loss				(16,520)	(16,520)
Ending balance, shares at Mar. 31, 2023	24,816,940
Ending balance, value at Mar. 31, 2023	$ 2	217,717	(201)	(104,423)	113,095
Beginning balance, shares at Dec. 31, 2022	24,722,974
Beginning balance, value at Dec. 31, 2022	$ 2	215,110	(466)	(87,903)	126,743
Net loss					(35,545)
Ending balance, shares at Jun. 30, 2023	27,601,098
Ending balance, value at Jun. 30, 2023	$ 3	265,594	(223)	(123,448)	141,926
Beginning balance, shares at Mar. 31, 2023	24,816,940
Beginning balance, value at Mar. 31, 2023	$ 2	217,717	(201)	(104,423)	113,095
Unrealized loss on investments			(22)		(22)
Issuance of common stock in connection with ATM, net	$ 1	44,282			44,283
Issuance of common stock in connection with ATM, net, shares	2,662,721
Issuance of common stock upon exercise of stock options		333			333
Issuance of common stock upon exercise of stock options (in shares)	106,756
Issuance of common stock under ESPP		228			228
Issuance of common stock under ESPP, shares	13,866
Vesting of restricted stock units, shares	815
Stock based compensation		3,034			3,034
Net loss				(19,025)	(19,025)
Ending balance, shares at Jun. 30, 2023	27,601,098
Ending balance, value at Jun. 30, 2023	$ 3	265,594	(223)	(123,448)	141,926
Beginning balance, shares at Dec. 31, 2023	27,762,703
Beginning balance, value at Dec. 31, 2023	$ 3	272,640	237	(163,424)	109,456
Unrealized loss on investments			(270)		(270)
Issuance of common stock upon exercise of stock options		704			704
Issuance of common stock upon exercise of stock options (in shares)	133,282
Vesting of restricted stock units, shares	2,776
Stock based compensation		4,200			4,200
Net loss				(23,186)	(23,186)
Ending balance, shares at Mar. 31, 2024	27,898,761
Ending balance, value at Mar. 31, 2024	$ 3	277,544	(33)	(186,610)	90,904
Beginning balance, shares at Dec. 31, 2023	27,762,703
Beginning balance, value at Dec. 31, 2023	$ 3	272,640	237	(163,424)	$ 109,456
Issuance of common stock upon exercise of stock options (in shares)					252,521
Net loss					$ (47,961)
Ending balance, shares at Jun. 30, 2024	28,854,750
Ending balance, value at Jun. 30, 2024	$ 3	305,863	(83)	(211,385)	94,398
Beginning balance, shares at Mar. 31, 2024	27,898,761
Beginning balance, value at Mar. 31, 2024	$ 3	277,544	(33)	(186,610)	90,904
Unrealized loss on investments			(50)		(50)
Issuance of common stock in connection with ATM, net		23,635			23,635
Issuance of common stock in connection with ATM, net, shares	800,000
Issuance of common stock upon exercise of stock options		511			511
Issuance of common stock upon exercise of stock options (in shares)	119,239
Issuance of common stock under ESPP		308			308
Issuance of common stock under ESPP, shares	34,034
Vesting of restricted stock units, shares	2,716
Stock based compensation		3,865			3,865
Net loss				(24,775)	(24,775)
Ending balance, shares at Jun. 30, 2024	28,854,750
Ending balance, value at Jun. 30, 2024	$ 3	$ 305,863	$ (83)	$ (211,385)	$ 94,398

Condensed Consolidated Statem_3

Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($) $ in Thousands	6 Months Ended
	Jun. 30, 2024	Jun. 30, 2023
Cash flow from operating activities:
Net loss	$ (47,961)	$ (35,545)
Adjustments to reconcile net loss to net cash used in operating activities:
Stock-based compensation expense	8,065	5,418
Depreciation and amortization expense	56	43
Accretion of discounts and amortization of premiums on investments, net	(1,451)	(1,310)
Changes in operating assets and liabilities:
Prepaid expenses and other current assets	(4,765)	(98)
Other long-term assets	2,510	(55)
Accounts payable	1,783	2,894
Accrued and other liabilities	(2,455)	2,554
Operating lease assets and liabilities, net	(1)	(43)
Other liabilities	113	(225)
Net cash used in operating activities	(44,106)	(26,367)
Cash flow from investing activities:
Purchases of short-term investments	(14,750)	(48,346)
Maturities of short-term investments	41,583	67,750
Purchases of property and equipment		(46)
Net cash provided by investing activities	26,833	19,358
Cash flow from financing activities:
Proceeds from sale of common stock in connection with ATM, net	23,635	44,888
Payments for offering costs	(307)	(159)
Proceeds from issuance of common stock under ESPP	308	228
Proceeds from issuance of common stock upon exercise of stock options	1,215	556
Net cash provided by financing activities	24,851	45,513
Net increase in cash and cash equivalents	7,578	38,504
Cash and cash equivalents at the beginning of the year	23,491	22,397
Cash and cash equivalents at the end of the period	31,069	60,901
Supplemental disclosure of noncash investing and financing activities:
Right-of-use asset obtained in exchange for operating lease liability	$ 206
Deferred offering costs included in accounts payable		$ 75

ORGANIZATION AND NATURE OF OPER

ORGANIZATION AND NATURE OF OPERATIONS	6 Months Ended
ORGANIZATION AND NATURE OF OPERATIONS	Jun. 30, 2024
ORGANIZATION AND NATURE OF OPERATIONS
ORGANIZATION AND NATURE OF OPERATIONS	(1) ORGANIZATION AND NATURE OF OPERATIONS (a) Organization and Nature of Operations Aerovate Therapeutics Inc. (“Aerovate” or the “Company”) was incorporated in the state of Delaware in July 2018, and is headquartered in Waltham, Massachusetts. The Company has a wholly owned subsidiary, Aerovate Securities Corporation. The Company is a biopharmaceutical company. The Company’s initial focus was on advancing AV-101, the Company’s dry powder inhaled formulation of imatinib for the treatment of pulmonary arterial hypertension (“PAH”). However, in June 2024, the Company announced negative results from the Phase 2b portion of its global Phase 2b/Phase 3 trial of AV-101 in adults with PAH, and, as a result, the Company decided to halt enrollment and shut down the Phase 3 portion of the Phase 2b/Phase 3 trial as well as the long-term extension study. In July 2024, the Company engaged Wedbush PacGrow as the Company’s exclusive strategic financial advisor to assist in the process of exploring strategic alternatives, which may include but are not limited to, an acquisition, merger, reverse merger, business combination, liquidation or other transaction. (b) At-the-Market Offering On April 5, 2023, the Company entered into an ATM Equity Offering SM (c) Liquidity and Management Plans Since inception, the Company has devoted substantially all of its resources to research and development activities, business planning, establishing and maintaining its intellectual property portfolio, hiring personnel, raising capital, and providing general and administrative support for these operations and has not realized revenues from its planned principal operations. The Company has incurred losses and negative cash flows from operations since inception. As of June 30, 2024, the Company had cash and cash equivalents and short-term investments of $104.2 million. Management believes that the Company’s current cash and cash equivalents and short-term investments will provide sufficient funds to enable the Company to meet its obligations for at least twelve months from the filing date of this report while it explores strategic alternatives.

BASIS OF PRESENTATION AND SIGNI

BASIS OF PRESENTATION AND SIGNIFICANT ACCOUNTING POLICIES	6 Months Ended
BASIS OF PRESENTATION AND SIGNIFICANT ACCOUNTING POLICIES	Jun. 30, 2024
BASIS OF PRESENTATION AND SIGNIFICANT ACCOUNTING POLICIES
BASIS OF PRESENTATION AND SIGNIFICANT ACCOUNTING POLICIES	(2) BASIS OF PRESENTATION AND SIGNIFICANT ACCOUNTING POLICIES (a) Basis of Presentation The accompanying unaudited condensed consolidated financial statements as of June 30, 2024 and for the three and six months ended June 30, 2024 and 2023 have been prepared in conformity with generally accepted accounting principles (“GAAP”) in the United States of America for interim financial information and pursuant to Article 10 of Regulation S-X of the Securities Act of 1933, as amended (the Securities Act). Accordingly, they do not include all of the information and notes required by GAAP for complete financial statements. These unaudited condensed consolidated financial statements include only normal and recurring adjustments that the Company believes are necessary to fairly state the Company’s financial position and the results of its operations and cash flows. The results for the three and six months ended June 30, 2024 are not necessarily indicative of the results expected for the full fiscal year or any subsequent interim period. The condensed consolidated balance sheet as of December 31, 2023 has been derived from the audited financial statements at that date but does not include all disclosures required by GAAP for complete financial statements. Because all of the disclosures required by GAAP for complete financial statements are not included herein, these unaudited condensed consolidated financial statements and the notes accompanying them should be read in conjunction with the Company’s audited financial statements for the year ended December 31, 2023. Any reference in these notes to applicable guidance is meant to refer to the authoritative GAAP as found in the Accounting Standards Codification (“ASC”) and Accounting Standards Update (“ASU”) of the Financial Accounting Standards Board (“FASB”). (b) Use of Estimates The preparation of the Company’s consolidated financial statements in conformity with U.S. GAAP requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities and the disclosure of contingent assets and liabilities as of the date of the consolidated financial statements and the reported amounts of expenses during the reporting period. Reported amounts and note disclosures reflect the overall economic conditions that are most likely to occur and anticipated measures management intends to take. Actual results could differ materially from those estimates. Accounting estimates and management judgements reflected in the consolidated financial statements include: normal recurring accruals, including the accrual for research and development expenses, stock-based compensation, fair value of investments, and operating lease right-of-use assets and lease liabilities. Estimates and assumptions are reviewed quarterly. Any revisions to accounting estimates are recognized in the period in which the estimates are revised and in any future periods affected. (c) Net Loss Per Share Basic net loss per share is calculated by dividing the net loss attributable to common stockholders by the weighted-average number of common shares outstanding for the period, without consideration of potential dilutive securities. Diluted net loss per share is computed by dividing the net loss attributable to common stockholders by the sum of the weighted average number of common shares plus the potential dilutive effects of potential dilutive securities outstanding during the period. Potential dilutive securities are excluded from diluted earnings or loss per share if the effect of such inclusion is antidilutive. The Company’s potentially dilutive securities have been excluded from the computation of diluted net loss per share as they would be anti-dilutive to the net loss per share. For all periods presented, there is no difference in the number of shares used to calculate basic and diluted shares outstanding due to the Company’s net loss position. The following table summarizes the Company’s net loss per share (in thousands, except share and per share amounts): Three Months Ended June 30, Six Months Ended June 30, 2024 2023 2024 2023 Numerator: Net loss $ (24,775) $ (19,025) $ (47,961) $ (35,545) Net loss attributable to common stockholders $ (24,775) $ (19,025) $ (47,961) $ (35,545) Denominator: Weighted-average common stock outstanding, basic and diluted 28,756,043 25,166,505 28,566,924 24,973,250 Net loss per share, basic and diluted $ (0.86) $ (0.76) $ (1.68) $ (1.42) Potentially dilutive securities not included in the calculation of diluted net loss per share attributable to common stockholders because to do so would have had an anti-dilutive effect are as follows (in common stock equivalent shares): As of June 30, 2024 2023 Options to purchase common stock 5,628,960 5,158,609 Unvested restricted stock units — 31,066 5,628,960 5,189,675 (d) Recently Issued and Recently Adopted Accounting Pronouncements In November 2023, the FASB issued ASU 2023-07, Segment Reporting (Topic 280) In December 2023, the FASB issued ASU 2023-09, Income Taxes (Topic 740)

FAIR VALUE OF FINANCIAL INSTRUM

FAIR VALUE OF FINANCIAL INSTRUMENTS	6 Months Ended
FAIR VALUE OF FINANCIAL INSTRUMENTS	Jun. 30, 2024
FAIR VALUE OF FINANCIAL INSTRUMENTS
FAIR VALUE OF FINANCIAL INSTRUMENTS	(3) FAIR VALUE OF FINANCIAL INSTRUMENTS The following tables summarize the Company’s financial assets measured at fair value on a recurring basis and their respective input levels based on the fair value hierarchy (in thousands): Fair Value Measurements Using Quoted Prices in Active Markets Significant Other Significant for Identical Observable Unobservable June 30, Assets Inputs Inputs 2024 (Level 1) (Level 2) (level 3) Assets: Cash equivalents Money market funds $ 18,343 $ 18,343 $ — $ — Commercial paper 2,988 — 2,988 — Total cash equivalents 21,331 18,343 2,988 — Short-term investments Agency bonds 37,367 — 37,367 — Commercial paper 19,503 — 19,503 — U.S. Treasury bills 9,420 9,420 — — Corporate debt securities 6,843 — 6,843 — Total short-term investments 73,133 9,420 63,713 — Total fair value of assets $ 94,464 $ 27,763 $ 66,701 $ — Fair Value Measurements Using Quoted Prices in Active Markets Significant Other Significant for Identical Observable Unobservable December 31, Assets Inputs Inputs 2023 (Level 1) (Level 2) (level 3) Assets: Cash equivalents Money market funds $ 19,787 $ 19,787 $ — $ — Total cash equivalents 19,787 19,787 — — Short-term investments Agency bonds 42,255 42,255 Commercial paper 38,386 — 38,386 — U.S. Treasury bills 10,362 10,362 — — Corporate debt securities 7,945 — 7,945 — Total short-term investments 98,948 10,362 88,586 — Total fair value of assets $ 118,735 $ 30,149 $ 88,586 $ — Cash Equivalents and Short-Term Investments Financial assets measured at fair value on a recurring basis consist of the Company’s cash equivalents and short-term investments. Cash equivalents consisted of money market funds and commercial paper, and short-term investments consisted of U.S. Treasury bills, agency bonds, corporate debt securities, and commercial paper. The Company obtains pricing information from its investment manager and generally determines the fair value of investment securities using standard observable inputs, including reported trades, broker/dealer quotes, and bids and/or offers. The following tables summarize the Company’s short-term investments (in thousands): As of June 30, 2024 Gross Gross Amortized unrealized unrealized Estimated fair Maturity cost gains losses value Agency bonds 2 years or less 37,409 9 (51) 37,367 Commercial paper 2 years or less 19,508 3 (8) 19,503 U.S. Treasury bills 2 years or less 9,439 — (19) 9,420 Corporate debt securities 2 years or less 6,860 — (17) 6,843 $ 73,216 $ 12 $ (95) $ 73,133 As of December 31, 2023 Gross Gross Amortized unrealized unrealized Estimated fair Maturity cost gains losses value Agency bonds 2 years or less $ 42,090 179 (14) $ 42,255 Commercial paper 2 years or less 38,362 29 (5) 38,386 U.S. Treasury bills 2 years or less 10,334 31 (3) 10,362 Corporate debt securities 2 years or less 7,925 21 (1) 7,945 $ 98,711 $ 260 $ (23) $ 98,948 The following tables summarize the Company’s short-term investments with unrealized losses for less than 12 months and 12 months or greater (in thousands): As of June 30, 2024 Less than 12 months 12 months or Greater Unrealized Unrealized Total Total Unrealized Fair Value Losses Fair Value Losses Fair Value Losses Agency bonds $ 17,234 $ (35) $ 12,498 $ (15) $ 29,732 $ (50) Commercial paper 8,866 (8) — — 8,866 (8) U.S. Treasury bills 7,380 (17) 1,975 (3) 9,355 (20) Corporate debt securities 6,843 (17) — — 6,843 (17) $ 40,323 $ (77) $ 14,473 $ (18) $ 54,796 $ (95) As of December 31, 2023 Less than 12 months 12 months or Greater Unrealized Unrealized Total Total Unrealized Fair Value Losses Fair Value Losses Fair Value Losses Commercial paper $ 6,042 $ (5) $ — $ — $ 6,042 $ (5) Agency bonds 3,760 (6) 6,579 (8) 10,339 (14) U.S. Treasury bills 488 (2) 1,007 (1) 1,495 (3) Corporate debt securities 3,110 (1) — — 3,110 (1) $ 13,400 $ (14) $ 7,586 $ (9) $ 20,986 $ (23) The Company considers whether unrealized losses have resulted from a credit loss or other factors. The unrealized losses on the Company’s short-term investments as of June 30, 2024 and December 31, 2023 were caused by fluctuations in market value and interest rates as a result of the economic environment and not credit risk. As of June 30, 2024 and December 31, 2023, no allowance for credit losses was recorded. During the six months ended June 30, 2024, the Company did not recognize any impairment losses related to its short-term investments. It is neither management’s intention to sell nor is it more likely than not that the Company will be required to sell these investments prior to recovery of their cost basis or recovery of fair value. Unrealized gains and losses are included in accumulated other comprehensive gain (loss). Accrued interest receivable is written off through net realized investment gains (losses) at the time the issuer of the bond defaults or is expected to default on payment. Accrued interest receivable related to short-term investments was $0.5 million as of June 30, 2024 and $0.6 million as of December 31, 2023.

BALANCE SHEET COMPONENTS

BALANCE SHEET COMPONENTS	6 Months Ended
BALANCE SHEET COMPONENTS	Jun. 30, 2024
BALANCE SHEET COMPONENTS
BALANCE SHEET COMPONENTS	(4) BALANCE SHEET COMPONENTS Prepaid Expenses and Other Current Assets Prepaid expenses and other current assets consisted of the following (in thousands): June 30, December 31, 2024 2023 Prepaid research and development $ 4,810 $ 375 Prepaid expenses 1,296 1,168 Other current assets 452 250 Total prepaid expenses and other current assets $ 6,558 $ 1,793 Accrued and Other Current Liabilities In June 2024, following the Company’s decision to halt further development of AV-101, the Company announced its plan to terminate nearly all of its workforce in the coming months (the “Workforce Reduction Plan”). As of July 31, 2024, 35 individuals, or 69% of the Company’s workforce, have been terminated. The affected individuals have been and will be provided severance benefits, including cash severance payments. Each affected individual’s eligibility for severance benefits is contingent upon entering into a separation agreement, which includes a general release of claims against the Company. In connection with the Workforce Reduction Plan, the Company estimates that it will incur costs (in consideration of releases) of approximately $5.6 million, which are primarily one-time severance benefits. Approximately $2.6 million of these costs were incurred in the second quarter of 2024, and the remaining are expected to be incurred in the third and fourth quarter of 2024. Accrued and other current liabilities consisted of the following (in thousands): June 30, December 31, 2024 2023 Accrued research and development $ 9,034 $ 9,363 Accrued payroll and other employee benefits 2,663 4,368 Other 669 1,090 Total accrued and other current liabilities $ 12,366 $ 14,821

COMMITMENTS AND CONTINGENCIES

COMMITMENTS AND CONTINGENCIES	6 Months Ended
COMMITMENTS AND CONTINGENCIES	Jun. 30, 2024
COMMITMENTS AND CONTINGENCIES
COMMITMENTS AND CONTINGENCIES	(5) COMMITMENTS AND CONTINGENCIES In August 2021, the Company entered into a lease agreement (the “Waltham Lease”) for approximately 5,000 square feet of office space in Waltham, Massachusetts for the Company’s corporate headquarters. The Waltham Lease has a term of thirty-nine months (“Lease Term”), unless extended or earlier terminated. The Company had the option to extend the Waltham Lease for one additional period of three years. The Lease Term has an initial abatement period, and the initial base rent payable is approximately $18,000 per month following the abatement period. The initial base rent payable will increase by approximately 2% per year over the Lease Term. The Waltham Lease commencement date was September 1, 2021. In January 2024, the Company entered into the First Amendment to the Waltham Lease resulting in the lease expiring on December 31, 2025, and an increase of $1.00 per rentable square foot during the additional lease term. In obtaining this lease extension, the Company no longer has the option to extend the Waltham Lease for one additional period of three years. In April 2022, the Company entered into a lease agreement (the “Foster City Lease”) for approximately 3,500 square feet of office space in Foster City, California. The Foster City Lease has a term of thirty-nine months, unless extended or earlier terminated. The Company has the option to extend the Foster City Lease for an additional period of one year. The base rent payable under the Foster City Lease is $22,600 per month and will be subject to annual increase of 3% on each anniversary. As of June 30, 2024, the future minimum annual lease payments under the operating leases were as follows (in thousands): Total Minimum Lease Payments 2024 $ 468 2025 242 Total operating lease payments 710 Less: Amount representing interest (29) Present value of net minimum lease payments $ 681 As the Company’s leases do not provide an implicit rate, the Company uses an incremental borrowing rate based on the information available at the lease commencement date. The components of operating leases as of June 30, 2024 and as of December 31, 2023 were as follows (in thousands except lease term and discount rate): June 30, December 31, Operating lease liabilities: 2024 2023 Current 475 420 Non-current 206 255 Total lease liabilities $ 681 $ 675 Weighted-average remaining lease term (in years) 1.4 1.5 Weighted-average incremental borrowing rate 6.4 % 6.0 % Supplemental cash flow information related to cash paid for amounts included in the measurement of operating lease liabilities was as follows (in thousands): Six months ended June 30, 2024 2023 Cash paid included in operating cash flows $ 254 $ 246 Rent expense was as follows (in thousands): Three months ended June 30, Six months ended June 30, 2024 2023 2024 2023 Operating lease $ 114 $ 111 $ 228 $ 221 Short-term lease 83 — 165 — Total rent expense $ 197 $ 111 $ 393 $ 221

STOCKHOLDERS' EQUITY

STOCKHOLDERS' EQUITY	6 Months Ended
STOCKHOLDERS' EQUITY	Jun. 30, 2024
STOCKHOLDERS' EQUITY
STOCKHOLDERS' EQUITY	(6) STOCKHOLDERS’ EQUITY On July 2, 2021, the Company’s certificate of amendment to its certificate of incorporation became effective, which provided 150,000,000 authorized shares of common stock with a par value of $0.0001 per share and 10,000,000 authorized shares of undesignated preferred stock with a par value of $0.0001 per share. The holders of the common stock are entitled to one vote for each share of common stock held at all meetings of stockholders. As of June 30, 2024, the Company had reserved the following shares of common stock, on an as-converted basis, for future issuance: June 30, 2024 Common stock options granted and outstanding 5,628,960 Shares reserved for issuance under the 2021 Plan 1,080,210 Reserved for future ESPP issuances 401,218 Total 7,110,388

SHARE-BASED COMPENSATION

SHARE-BASED COMPENSATION	6 Months Ended
SHARE-BASED COMPENSATION	Jun. 30, 2024
SHARE-BASED COMPENSATION
SHARE-BASED COMPENSATION	(7) STOCK-BASED COMPENSATION (a) Stock Option Plan The Company’s 2021 Stock Option and Incentive Plan (the “2021 Plan”) was adopted by the Company’s board of directors and approved by the Company’s stockholders in June 2021 and became effective as of June 29, 2021. Upon the effectiveness of the 2021 Plan, the Company’s 2018 Equity Incentive Plan (the “2018 Plan”) was terminated and no further grants may be made thereunder. The Company’s 2021 Plan allows for the grant of incentive stock options, non-qualified stock options, stock appreciation rights, stock bonuses, restricted stock, stock units and other forms of awards including cash awards to its officers, directors, employees, consultants and advisors. As of June 30, 2024, a total of 5,675,841 shares of the Company’s common stock were authorized for issuance with respect to awards granted under the 2021 Plan, of which 1,080,210 shares remain available for issuance. The share limit will automatically increase on the first trading day in January of each year (commencing with 2022) by an amount equal to the lesser of (1) 4% of the total number of outstanding shares of the Company’s common stock on the last trading day in December in the prior year, or (2) such lesser number as determined by the Company’s board of directors. Since adoption, the number of shares available under the 2021 Plan pursuant to the annual increases totaled 3,075,841 shares through January 1, 2024. Any shares subject to awards granted under the 2021 Plan or the 2018 Plan that are not paid, delivered or exercised before they expire or are canceled or terminated, or otherwise fail to vest, as well as shares used to pay the purchase or exercise price of such awards or related tax withholding obligations, will become available for new award grants under the 2021 Plan. As of June 30, 2024, 4,520,814 and 1,108,146 options had been granted under the 2021 Plan and 2018 Plan, respectively. The options that are granted under the 2021 Plan and the 2018 Plan are exercisable at various dates as determined upon grant and terminate within 10 years of the date of grant. The vesting period generally occurs over three The following table summarizes the option activity under the 2021 Plan and 2018 Plan for the six months ended June 30, 2024: Weighted- Average Remaining Aggregate Weighted-Average Contractual Term Intrinsic Value Options Exercise Price (in years) (in thousands) Outstanding at December 31, 2023 5,230,344 $ 13.66 8.16 $ 49,728 Granted 1,489,191 19.70 Exercised (252,521) 4.82 Cancelled/Forfeited (838,054) 19.95 Outstanding at June 30, 2024 5,628,960 $ 14.72 7.60 $ — Vested and exercisable at June 30, 2024 2,829,947 12.78 6.73 — The weighted-average grant date fair value of stock option grants was $14.92 per share for the six months ended June 30, 2024. As of June 30, 2024, there was approximately $31.9 million of total unrecognized stock-based compensation expense related to unvested stock options granted under the 2021 Plan and 2018 Plan, which is expected to be recognized over a weighted-average period of approximately 2.3 years. (b) Employee Stock Purchase Plan The Company’s Employee Stock Purchase Plan (the “ESPP”) was adopted by the Company’s board of directors and stockholders in June 2021 and became effective upon the consummation of the IPO. A total of 230,000 shares of the Company’s common stock was initially available for issuance under the ESPP. The share limit will automatically increase on the first trading day in January of each year (commencing with 2022) by an amount equal to the lesser of (1) 1% of the total number of outstanding shares of the Company’s common stock on the last trading day in December in the prior year, or (2) such lesser number as determined by the Company’s board of directors. The number of shares available under the 2021 Plan increased by 247,229 shares effective January 1, 2023 as determined by the Company’s board of directors. The ESPP allows eligible employees to purchase shares of the Company’s common stock at a discount through payroll deductions of up to 15% of their eligible compensation, subject to any plan limitations. The ESPP provides for six-month offering periods, and at the end of each offering period, employees are able to purchase shares at 85% of the lower of the fair market value of the Company’s common stock on the first trading day of the offering period or on the last trading day of the offering period. As of June 30, 2024, 76,011 shares had been issued under the ESPP, and 401,218 shares authorized under the ESPP Plan were available for issuance. (c) Restricted Stock Units As of June 30, 2024, 31,881 restricted stock units had been awarded under the 2021 Plan. A summary of the status of and changes in unvested restricted stock unit activity under the Company’s equity award plans for the six months ended June 30, 2024 was as follows: Weighted- Average Grant Date Fair Value Units Per Unit Unvested restricted stock units as of December 31, 2023 21,968 $ 22.26 Granted — — Vested (5,492) 21.30 Forfeited (16,476) 22.58 Unvested restricted stock units as of June 30, 2024 — $ — Stock-based compensation of restricted stock units is based on the fair value of the Company’s common stock on the date of grant and recognized over the vesting period. The vesting period generally occurs over three As of June 30, 2024, the Company had no unrecognized stock-based compensation expense related to its unvested restricted stock units. (d) Stock-Based Compensation Expense Stock-based compensation expense recognized for all equity awards has been reported in the statements of operations and comprehensive loss as follows (in thousands): Three Months Ended June 30, Six Months Ended June 30, 2024 2023 2024 2023 Research and development $ 2,035 $ 1,682 $ 4,529 $ 2,981 General and administrative 1,830 1,352 3,536 2,437 Total $ 3,865 $ 3,034 $ 8,065 $ 5,418 Stock-based compensation expense by type of award included within the consolidated statements of operations and comprehensive income (loss) was as follows: Three Months Ended June 30, Six Months Ended June 30, 2024 2023 2024 2023 Stock options $ 3,808 $ 2,940 $ 7,876 $ 5,229 Restricted stock awards and units 16 51 62 99 Employee stock purchase plan awards 41 43 127 90 Total $ 3,865 $ 3,034 $ 8,065 $ 5,418

Pay vs Performance Disclosure

Pay vs Performance Disclosure - USD ($) $ in Thousands	3 Months Ended				6 Months Ended
Pay vs Performance Disclosure - USD ($) $ in Thousands	Jun. 30, 2024	Mar. 31, 2024	Jun. 30, 2023	Mar. 31, 2023	Jun. 30, 2024	Jun. 30, 2023
Pay vs Performance Disclosure
Net Income (Loss)	$ (24,775)	$ (23,186)	$ (19,025)	$ (16,520)	$ (47,961)	$ (35,545)

Insider Trading Arrangements

Insider Trading Arrangements - Ralph Niven [Member]	3 Months Ended
Insider Trading Arrangements - Ralph Niven [Member]	Jun. 30, 2024 shares
Trading Arrangements, by Individual
Name	Ralph Niven
Title	Chief Scientific Officer
Rule 10b5-1 Arrangement Adopted	true
Adoption Date	April 9, 2024
Aggregate Available	29,400
Expiration Date	April 9, 2025

BASIS OF PRESENTATION AND SIG_2

BASIS OF PRESENTATION AND SIGNIFICANT ACCOUNTING POLICIES (Policies)	6 Months Ended
	Jun. 30, 2024
BASIS OF PRESENTATION AND SIGNIFICANT ACCOUNTING POLICIES
Basis of Presentation	(a) Basis of Presentation The accompanying unaudited condensed consolidated financial statements as of June 30, 2024 and for the three and six months ended June 30, 2024 and 2023 have been prepared in conformity with generally accepted accounting principles (“GAAP”) in the United States of America for interim financial information and pursuant to Article 10 of Regulation S-X of the Securities Act of 1933, as amended (the Securities Act). Accordingly, they do not include all of the information and notes required by GAAP for complete financial statements. These unaudited condensed consolidated financial statements include only normal and recurring adjustments that the Company believes are necessary to fairly state the Company’s financial position and the results of its operations and cash flows. The results for the three and six months ended June 30, 2024 are not necessarily indicative of the results expected for the full fiscal year or any subsequent interim period. The condensed consolidated balance sheet as of December 31, 2023 has been derived from the audited financial statements at that date but does not include all disclosures required by GAAP for complete financial statements. Because all of the disclosures required by GAAP for complete financial statements are not included herein, these unaudited condensed consolidated financial statements and the notes accompanying them should be read in conjunction with the Company’s audited financial statements for the year ended December 31, 2023. Any reference in these notes to applicable guidance is meant to refer to the authoritative GAAP as found in the Accounting Standards Codification (“ASC”) and Accounting Standards Update (“ASU”) of the Financial Accounting Standards Board (“FASB”).
Use of Estimates	(b) Use of Estimates The preparation of the Company’s consolidated financial statements in conformity with U.S. GAAP requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities and the disclosure of contingent assets and liabilities as of the date of the consolidated financial statements and the reported amounts of expenses during the reporting period. Reported amounts and note disclosures reflect the overall economic conditions that are most likely to occur and anticipated measures management intends to take. Actual results could differ materially from those estimates. Accounting estimates and management judgements reflected in the consolidated financial statements include: normal recurring accruals, including the accrual for research and development expenses, stock-based compensation, fair value of investments, and operating lease right-of-use assets and lease liabilities. Estimates and assumptions are reviewed quarterly. Any revisions to accounting estimates are recognized in the period in which the estimates are revised and in any future periods affected.
Net Loss Per Share	(c) Net Loss Per Share Basic net loss per share is calculated by dividing the net loss attributable to common stockholders by the weighted-average number of common shares outstanding for the period, without consideration of potential dilutive securities. Diluted net loss per share is computed by dividing the net loss attributable to common stockholders by the sum of the weighted average number of common shares plus the potential dilutive effects of potential dilutive securities outstanding during the period. Potential dilutive securities are excluded from diluted earnings or loss per share if the effect of such inclusion is antidilutive. The Company’s potentially dilutive securities have been excluded from the computation of diluted net loss per share as they would be anti-dilutive to the net loss per share. For all periods presented, there is no difference in the number of shares used to calculate basic and diluted shares outstanding due to the Company’s net loss position. The following table summarizes the Company’s net loss per share (in thousands, except share and per share amounts): Three Months Ended June 30, Six Months Ended June 30, 2024 2023 2024 2023 Numerator: Net loss $ (24,775) $ (19,025) $ (47,961) $ (35,545) Net loss attributable to common stockholders $ (24,775) $ (19,025) $ (47,961) $ (35,545) Denominator: Weighted-average common stock outstanding, basic and diluted 28,756,043 25,166,505 28,566,924 24,973,250 Net loss per share, basic and diluted $ (0.86) $ (0.76) $ (1.68) $ (1.42) Potentially dilutive securities not included in the calculation of diluted net loss per share attributable to common stockholders because to do so would have had an anti-dilutive effect are as follows (in common stock equivalent shares): As of June 30, 2024 2023 Options to purchase common stock 5,628,960 5,158,609 Unvested restricted stock units — 31,066 5,628,960 5,189,675
Recently Issued and Recently Adopted Accounting Pronouncements	In November 2023, the FASB issued ASU 2023-07, Segment Reporting (Topic 280) In December 2023, the FASB issued ASU 2023-09, Income Taxes (Topic 740)

BASIS OF PRESENTATION AND SIG_3

BASIS OF PRESENTATION AND SIGNIFICANT ACCOUNTING POLICIES (Tables)	6 Months Ended
	Jun. 30, 2024
BASIS OF PRESENTATION AND SIGNIFICANT ACCOUNTING POLICIES
SCHEDULE OF NET LOSS PER SHARE	The following table summarizes the Company’s net loss per share (in thousands, except share and per share amounts): Three Months Ended June 30, Six Months Ended June 30, 2024 2023 2024 2023 Numerator: Net loss $ (24,775) $ (19,025) $ (47,961) $ (35,545) Net loss attributable to common stockholders $ (24,775) $ (19,025) $ (47,961) $ (35,545) Denominator: Weighted-average common stock outstanding, basic and diluted 28,756,043 25,166,505 28,566,924 24,973,250 Net loss per share, basic and diluted $ (0.86) $ (0.76) $ (1.68) $ (1.42)
SCHEDULE OF POTENTIALLY DILUTIVE SECURITIES NOT INCLUDED IN THE CALCULATION OF DILUTED NET LOSS PER SHARE	Potentially dilutive securities not included in the calculation of diluted net loss per share attributable to common stockholders because to do so would have had an anti-dilutive effect are as follows (in common stock equivalent shares): As of June 30, 2024 2023 Options to purchase common stock 5,628,960 5,158,609 Unvested restricted stock units — 31,066 5,628,960 5,189,675

FAIR VALUE OF FINANCIAL INSTR_2

FAIR VALUE OF FINANCIAL INSTRUMENTS (Tables)	6 Months Ended
FAIR VALUE OF FINANCIAL INSTRUMENTS (Tables)	Jun. 30, 2024
FAIR VALUE OF FINANCIAL INSTRUMENTS
SCHEDULE OF FAIR VALUE INSTRUMENTS	The following tables summarize the Company’s financial assets measured at fair value on a recurring basis and their respective input levels based on the fair value hierarchy (in thousands): Fair Value Measurements Using Quoted Prices in Active Markets Significant Other Significant for Identical Observable Unobservable June 30, Assets Inputs Inputs 2024 (Level 1) (Level 2) (level 3) Assets: Cash equivalents Money market funds $ 18,343 $ 18,343 $ — $ — Commercial paper 2,988 — 2,988 — Total cash equivalents 21,331 18,343 2,988 — Short-term investments Agency bonds 37,367 — 37,367 — Commercial paper 19,503 — 19,503 — U.S. Treasury bills 9,420 9,420 — — Corporate debt securities 6,843 — 6,843 — Total short-term investments 73,133 9,420 63,713 — Total fair value of assets $ 94,464 $ 27,763 $ 66,701 $ — Fair Value Measurements Using Quoted Prices in Active Markets Significant Other Significant for Identical Observable Unobservable December 31, Assets Inputs Inputs 2023 (Level 1) (Level 2) (level 3) Assets: Cash equivalents Money market funds $ 19,787 $ 19,787 $ — $ — Total cash equivalents 19,787 19,787 — — Short-term investments Agency bonds 42,255 42,255 Commercial paper 38,386 — 38,386 — U.S. Treasury bills 10,362 10,362 — — Corporate debt securities 7,945 — 7,945 — Total short-term investments 98,948 10,362 88,586 — Total fair value of assets $ 118,735 $ 30,149 $ 88,586 $ —
SCHEDULE OF SHORT TERM INVESTMENTS	The following tables summarize the Company’s short-term investments (in thousands): As of June 30, 2024 Gross Gross Amortized unrealized unrealized Estimated fair Maturity cost gains losses value Agency bonds 2 years or less 37,409 9 (51) 37,367 Commercial paper 2 years or less 19,508 3 (8) 19,503 U.S. Treasury bills 2 years or less 9,439 — (19) 9,420 Corporate debt securities 2 years or less 6,860 — (17) 6,843 $ 73,216 $ 12 $ (95) $ 73,133 As of December 31, 2023 Gross Gross Amortized unrealized unrealized Estimated fair Maturity cost gains losses value Agency bonds 2 years or less $ 42,090 179 (14) $ 42,255 Commercial paper 2 years or less 38,362 29 (5) 38,386 U.S. Treasury bills 2 years or less 10,334 31 (3) 10,362 Corporate debt securities 2 years or less 7,925 21 (1) 7,945 $ 98,711 $ 260 $ (23) $ 98,948
SCHEDULE OF SHORT-TERM INVESTMENTS WITH UNREALIZED LOSSES	The following tables summarize the Company’s short-term investments with unrealized losses for less than 12 months and 12 months or greater (in thousands): As of June 30, 2024 Less than 12 months 12 months or Greater Unrealized Unrealized Total Total Unrealized Fair Value Losses Fair Value Losses Fair Value Losses Agency bonds $ 17,234 $ (35) $ 12,498 $ (15) $ 29,732 $ (50) Commercial paper 8,866 (8) — — 8,866 (8) U.S. Treasury bills 7,380 (17) 1,975 (3) 9,355 (20) Corporate debt securities 6,843 (17) — — 6,843 (17) $ 40,323 $ (77) $ 14,473 $ (18) $ 54,796 $ (95) As of December 31, 2023 Less than 12 months 12 months or Greater Unrealized Unrealized Total Total Unrealized Fair Value Losses Fair Value Losses Fair Value Losses Commercial paper $ 6,042 $ (5) $ — $ — $ 6,042 $ (5) Agency bonds 3,760 (6) 6,579 (8) 10,339 (14) U.S. Treasury bills 488 (2) 1,007 (1) 1,495 (3) Corporate debt securities 3,110 (1) — — 3,110 (1) $ 13,400 $ (14) $ 7,586 $ (9) $ 20,986 $ (23)

BALANCE SHEET COMPONENTS (Table

BALANCE SHEET COMPONENTS (Tables)	6 Months Ended
BALANCE SHEET COMPONENTS (Tables)	Jun. 30, 2024
BALANCE SHEET COMPONENTS
SCHEDULE OF PREPAID EXPENSES AND OTHER CURRENT ASSETS	Prepaid expenses and other current assets consisted of the following (in thousands): June 30, December 31, 2024 2023 Prepaid research and development $ 4,810 $ 375 Prepaid expenses 1,296 1,168 Other current assets 452 250 Total prepaid expenses and other current assets $ 6,558 $ 1,793
SCHEDULE OF ACCRUED AND OTHER CURRENT LIABILITIES	Accrued and other current liabilities consisted of the following (in thousands): June 30, December 31, 2024 2023 Accrued research and development $ 9,034 $ 9,363 Accrued payroll and other employee benefits 2,663 4,368 Other 669 1,090 Total accrued and other current liabilities $ 12,366 $ 14,821

COMMITMENTS AND CONTINGENCIES (

COMMITMENTS AND CONTINGENCIES (Tables)	6 Months Ended
COMMITMENTS AND CONTINGENCIES (Tables)	Jun. 30, 2024
COMMITMENTS AND CONTINGENCIES
SCHEDULE OF FUTURE MINIMUM ANNUAL LEASE PAYMENTS FOR OPERATING LEASES	As of June 30, 2024, the future minimum annual lease payments under the operating leases were as follows (in thousands): Total Minimum Lease Payments 2024 $ 468 2025 242 Total operating lease payments 710 Less: Amount representing interest (29) Present value of net minimum lease payments $ 681
SCHEDULE OF SUPPLEMENTAL CASH FLOW	As the Company’s leases do not provide an implicit rate, the Company uses an incremental borrowing rate based on the information available at the lease commencement date. The components of operating leases as of June 30, 2024 and as of December 31, 2023 were as follows (in thousands except lease term and discount rate): June 30, December 31, Operating lease liabilities: 2024 2023 Current 475 420 Non-current 206 255 Total lease liabilities $ 681 $ 675 Weighted-average remaining lease term (in years) 1.4 1.5 Weighted-average incremental borrowing rate 6.4 % 6.0 % Supplemental cash flow information related to cash paid for amounts included in the measurement of operating lease liabilities was as follows (in thousands): Six months ended June 30, 2024 2023 Cash paid included in operating cash flows $ 254 $ 246
SCHEDULE OF OPERATING LEASE EXPENSE	Rent expense was as follows (in thousands): Three months ended June 30, Six months ended June 30, 2024 2023 2024 2023 Operating lease $ 114 $ 111 $ 228 $ 221 Short-term lease 83 — 165 — Total rent expense $ 197 $ 111 $ 393 $ 221

STOCKHOLDERS' EQUITY (Tables)

STOCKHOLDERS' EQUITY (Tables)	6 Months Ended
STOCKHOLDERS' EQUITY (Tables)	Jun. 30, 2024
STOCKHOLDERS' EQUITY
SCHEDULE OF COMMON STOCK SHARES RESERVED FOR ON AND AS-CONVERTED BASIS, FOR FUTURE ISSUANCE	As of June 30, 2024, the Company had reserved the following shares of common stock, on an as-converted basis, for future issuance: June 30, 2024 Common stock options granted and outstanding 5,628,960 Shares reserved for issuance under the 2021 Plan 1,080,210 Reserved for future ESPP issuances 401,218 Total 7,110,388

SHARE-BASED COMPENSATION (Table

SHARE-BASED COMPENSATION (Tables)	6 Months Ended
SHARE-BASED COMPENSATION (Tables)	Jun. 30, 2024
SHARE-BASED COMPENSATION
SCHEDULE OF OPTION ACTIVITY UNDER 2021 PLAN AND 2018 PLAN	Weighted- Average Remaining Aggregate Weighted-Average Contractual Term Intrinsic Value Options Exercise Price (in years) (in thousands) Outstanding at December 31, 2023 5,230,344 $ 13.66 8.16 $ 49,728 Granted 1,489,191 19.70 Exercised (252,521) 4.82 Cancelled/Forfeited (838,054) 19.95 Outstanding at June 30, 2024 5,628,960 $ 14.72 7.60 $ — Vested and exercisable at June 30, 2024 2,829,947 12.78 6.73 —
SCHEDULE OF UNVESTED RESTRICTED STOCK UNIT ACTIVITY	Weighted- Average Grant Date Fair Value Units Per Unit Unvested restricted stock units as of December 31, 2023 21,968 $ 22.26 Granted — — Vested (5,492) 21.30 Forfeited (16,476) 22.58 Unvested restricted stock units as of June 30, 2024 — $ —
SCHEDULE OF STOCK-BASED COMPENSATION EXPENSE	Stock-based compensation expense recognized for all equity awards has been reported in the statements of operations and comprehensive loss as follows (in thousands): Three Months Ended June 30, Six Months Ended June 30, 2024 2023 2024 2023 Research and development $ 2,035 $ 1,682 $ 4,529 $ 2,981 General and administrative 1,830 1,352 3,536 2,437 Total $ 3,865 $ 3,034 $ 8,065 $ 5,418 Stock-based compensation expense by type of award included within the consolidated statements of operations and comprehensive income (loss) was as follows: Three Months Ended June 30, Six Months Ended June 30, 2024 2023 2024 2023 Stock options $ 3,808 $ 2,940 $ 7,876 $ 5,229 Restricted stock awards and units 16 51 62 99 Employee stock purchase plan awards 41 43 127 90 Total $ 3,865 $ 3,034 $ 8,065 $ 5,418

ORGANIZATION AND NATURE OF OP_2

ORGANIZATION AND NATURE OF OPERATIONS (Details) - USD ($) $ in Thousands		6 Months Ended
	Apr. 05, 2023	Jun. 30, 2024	Jun. 30, 2023
Sale of Stock
Proceeds from issuance of common stock		$ 23,635	$ 44,888
Cash and cash equivalents and short-term investments		$ 104,200
BofA Securities, Inc.
Sale of Stock
Aggregate amount of shares	$ 75,000
Shares sold		3,462,721
Proceeds from issuance of common stock		$ 67,900
Value of remaining common stock available for sale under ATM Program		$ 6,000

BASIS OF PRESENTATION AND SIG_4

BASIS OF PRESENTATION AND SIGNIFICANT ACCOUNTING POLICIES - SCHEDULE OF NET LOSS PER SHARE (Details) - USD ($) $ / shares in Units, $ in Thousands	3 Months Ended				6 Months Ended
	Jun. 30, 2024	Mar. 31, 2024	Jun. 30, 2023	Mar. 31, 2023	Jun. 30, 2024	Jun. 30, 2023
BASIS OF PRESENTATION AND SIGNIFICANT ACCOUNTING POLICIES
Net loss	$ (24,775)	$ (23,186)	$ (19,025)	$ (16,520)	$ (47,961)	$ (35,545)
Net loss attributable to common stockholders	$ (24,775)		$ (19,025)		$ (47,961)	$ (35,545)
Weighted-average common stock outstanding, basic	28,756,043		25,166,505		28,566,924	24,973,250
Weighted-average common stock outstanding, diluted	28,756,043		25,166,505		28,566,924	24,973,250
Net loss per share, basic	$ (0.86)		$ (0.76)		$ (1.68)	$ (1.42)
Net loss per share, diluted	$ (0.86)		$ (0.76)		$ (1.68)	$ (1.42)

BASIS OF PRESENTATION AND SIG_5

BASIS OF PRESENTATION AND SIGNIFICANT ACCOUNTING POLICIES - SCHEDULE OF POTENTIALLY DILUTIVE SECURITIES NOT INCLUDED IN THE CALCULATION OF DILUTED NET LOSS PER SHARE (Details) - shares	6 Months Ended
	Jun. 30, 2024	Jun. 30, 2023
Antidilutive Securities
Antidilutive Securities	5,628,960	5,189,675
Options to purchase common stock
Antidilutive Securities
Antidilutive Securities	5,628,960	5,158,609
Restricted stock units
Antidilutive Securities
Antidilutive Securities		31,066

FAIR VALUE OF FINANCIAL INSTR_3

FAIR VALUE OF FINANCIAL INSTRUMENTS - SCHEDULE OF FAIR VALUE INSTRUMENTS (Details) - USD ($) $ in Thousands	Jun. 30, 2024	Dec. 31, 2023
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis
Total short-term investments	$ 73,133	$ 98,948
Fair Value, Recurring
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis
Total cash equivalents	21,331	19,787
Total short-term investments	73,133	98,948
Total fair value of assets	94,464	118,735
Fair Value, Recurring \| Fair Value, Inputs, Level 1
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis
Total cash equivalents	18,343	19,787
Total short-term investments	9,420	10,362
Total fair value of assets	27,763	30,149
Fair Value, Recurring \| Fair Value, Inputs, Level 2
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis
Total cash equivalents	2,988
Total short-term investments	63,713	88,586
Total fair value of assets	66,701	88,586
Fair Value, Recurring \| Fair Value, Inputs, Level 3
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis
Total cash equivalents
Total short-term investments
Total fair value of assets
Money market funds \| Fair Value, Recurring
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis
Total cash equivalents	18,343	19,787
Money market funds \| Fair Value, Recurring \| Fair Value, Inputs, Level 1
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis
Total cash equivalents	18,343	19,787
Money market funds \| Fair Value, Recurring \| Fair Value, Inputs, Level 2
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis
Total cash equivalents
Money market funds \| Fair Value, Recurring \| Fair Value, Inputs, Level 3
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis
Total cash equivalents
Commercial paper \| Fair Value, Recurring
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis
Total cash equivalents	2,988
Commercial paper \| Fair Value, Recurring \| Fair Value, Inputs, Level 2
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis
Total cash equivalents	2,988
Agency bond \| Fair Value, Recurring
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis
Total short-term investments	37,367	42,255
Agency bond \| Fair Value, Recurring \| Fair Value, Inputs, Level 1
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis
Total short-term investments
Agency bond \| Fair Value, Recurring \| Fair Value, Inputs, Level 2
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis
Total short-term investments	37,367	42,255
Agency bond \| Fair Value, Recurring \| Fair Value, Inputs, Level 3
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis
Total short-term investments
Commercial paper \| Fair Value, Recurring
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis
Total short-term investments	19,503	38,386
Commercial paper \| Fair Value, Recurring \| Fair Value, Inputs, Level 1
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis
Total short-term investments
Commercial paper \| Fair Value, Recurring \| Fair Value, Inputs, Level 2
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis
Total short-term investments	19,503	38,386
Commercial paper \| Fair Value, Recurring \| Fair Value, Inputs, Level 3
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis
Total short-term investments
U.S. Treasury bills \| Fair Value, Recurring
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis
Total short-term investments	9,420	10,362
U.S. Treasury bills \| Fair Value, Recurring \| Fair Value, Inputs, Level 1
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis
Total short-term investments	9,420	10,362
U.S. Treasury bills \| Fair Value, Recurring \| Fair Value, Inputs, Level 2
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis
Total short-term investments
U.S. Treasury bills \| Fair Value, Recurring \| Fair Value, Inputs, Level 3
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis
Total short-term investments
Corporate debt securities \| Fair Value, Recurring
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis
Total short-term investments	6,843	7,945
Corporate debt securities \| Fair Value, Recurring \| Fair Value, Inputs, Level 1
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis
Total short-term investments
Corporate debt securities \| Fair Value, Recurring \| Fair Value, Inputs, Level 2
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis
Total short-term investments	$ 6,843	7,945
Corporate debt securities \| Fair Value, Recurring \| Fair Value, Inputs, Level 3
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis
Total short-term investments

FAIR VALUE OF FINANCIAL INSTR_4

FAIR VALUE OF FINANCIAL INSTRUMENTS - SCHEDULE OF SHORT TERM INVESTMENT (Details) - USD ($) $ in Thousands	6 Months Ended	12 Months Ended
	Jun. 30, 2024	Dec. 31, 2023
Fair Value, off-Balance-Sheet Risks, Disclosure Information
Amortized cost	$ 73,216	$ 98,711
Gross unrealized gains	12	260
Gross unrealized losses	(95)	(23)
Estimated fair value	73,133	98,948
Allowance for credit loss	0	0
Accrued interest receivable	$ 500	$ 600
Debt Securities, Available-for-Sale, Accrued Interest, after Allowance for Credit Loss, Current, Statement of Financial Position [Extensible Enumeration]	Short-term investments	Short-term investments
Agency bond
Fair Value, off-Balance-Sheet Risks, Disclosure Information
Amortized cost	$ 37,409	$ 42,090
Gross unrealized gains	9	179
Gross unrealized losses	(51)	(14)
Estimated fair value	37,367	42,255
Commercial paper
Fair Value, off-Balance-Sheet Risks, Disclosure Information
Amortized cost	19,508	38,362
Gross unrealized gains	3	29
Gross unrealized losses	(8)	(5)
Estimated fair value	19,503	38,386
U.S. Treasury bills
Fair Value, off-Balance-Sheet Risks, Disclosure Information
Amortized cost	9,439	10,334
Gross unrealized gains		31
Gross unrealized losses	(19)	(3)
Estimated fair value	9,420	10,362
Corporate debt securities
Fair Value, off-Balance-Sheet Risks, Disclosure Information
Amortized cost	6,860	7,925
Gross unrealized gains		21
Gross unrealized losses	(17)	(1)
Estimated fair value	$ 6,843	$ 7,945
Maximum \| Agency bond
Fair Value, off-Balance-Sheet Risks, Disclosure Information
Maturity term	2 years	2 years
Maximum \| Commercial paper
Fair Value, off-Balance-Sheet Risks, Disclosure Information
Maturity term	2 years	2 years
Maximum \| U.S. Treasury bills
Fair Value, off-Balance-Sheet Risks, Disclosure Information
Maturity term	2 years	2 years
Maximum \| Corporate debt securities
Fair Value, off-Balance-Sheet Risks, Disclosure Information
Maturity term	2 years	2 years

FAIR VALUE OF FINANCIAL INSTR_5

FAIR VALUE OF FINANCIAL INSTRUMENTS - SCHEDULE OF SHORT-TERM INVESTMENTS WITH UNREALIZED LOSSES (Details) - USD ($) $ in Thousands	Jun. 30, 2024	Dec. 31, 2023
Debt Securities, Available-for-Sale, Unrealized Loss Position
Short-term investments, Less than 12 months, Fair Value	$ 40,323	$ 13,400
Short-term investments, Less than 12 months, Unrealized Losses	(77)	(14)
Short-term investments, 12 months or Greater, Fair Value	14,473	7,586
Short-term investments, 12 months or Greater, Unrealized Losses	(18)	(9)
Short-term investments, Total Fair Value	54,796	20,986
Short-term investments, Total Unrealized Losses	(95)	(23)
Agency bond
Debt Securities, Available-for-Sale, Unrealized Loss Position
Short-term investments, Less than 12 months, Fair Value	17,234	3,760
Short-term investments, Less than 12 months, Unrealized Losses	(35)	(6)
Short-term investments, 12 months or Greater, Fair Value	12,498	6,579
Short-term investments, 12 months or Greater, Unrealized Losses	(15)	(8)
Short-term investments, Total Fair Value	29,732	10,339
Short-term investments, Total Unrealized Losses	(50)	(14)
Commercial paper
Debt Securities, Available-for-Sale, Unrealized Loss Position
Short-term investments, Less than 12 months, Fair Value	8,866	6,042
Short-term investments, Less than 12 months, Unrealized Losses	(8)	(5)
Short-term investments, Total Fair Value	8,866	6,042
Short-term investments, Total Unrealized Losses	(8)	(5)
U.S. Treasury bills
Debt Securities, Available-for-Sale, Unrealized Loss Position
Short-term investments, Less than 12 months, Fair Value	7,380	488
Short-term investments, Less than 12 months, Unrealized Losses	(17)	(2)
Short-term investments, 12 months or Greater, Fair Value	1,975	1,007
Short-term investments, 12 months or Greater, Unrealized Losses	(3)	(1)
Short-term investments, Total Fair Value	9,355	1,495
Short-term investments, Total Unrealized Losses	(20)	(3)
Corporate debt securities
Debt Securities, Available-for-Sale, Unrealized Loss Position
Short-term investments, Less than 12 months, Fair Value	6,843	3,110
Short-term investments, Less than 12 months, Unrealized Losses	(17)	(1)
Short-term investments, Total Fair Value	6,843	3,110
Short-term investments, Total Unrealized Losses	$ (17)	$ (1)

BALANCE SHEET COMPONENTS - SCHE

BALANCE SHEET COMPONENTS - SCHEDULE OF PREPAID EXPENSES AND OTHER CURRENT ASSETS (Details) - USD ($) $ in Thousands	Jun. 30, 2024	Dec. 31, 2023
BALANCE SHEET COMPONENTS
Prepaid research and development	$ 4,810	$ 375
Prepaid expenses	1,296	1,168
Other current assets	452	250
Total prepaid expenses and other current assets	$ 6,558	$ 1,793

BALANCE SHEET COMPONENTS - SC_2

BALANCE SHEET COMPONENTS - SCHEDULE OF ACCRUED AND OTHER CURRENT LIABILITIES - (Details) - USD ($) $ in Thousands	Jun. 30, 2024	Dec. 31, 2023
BALANCE SHEET COMPONENTS
Accrued research and development	$ 9,034	$ 9,363
Accrued payroll and other employee benefits	2,663	4,368
Other	669	1,090
Total accrued and other current liabilities	$ 12,366	$ 14,821

BALANCE SHEET COMPONENTS - WORK

BALANCE SHEET COMPONENTS - WORKFORCE REDUCTION PLAN (Details) $ in Millions	3 Months Ended
	Jun. 30, 2024 USD ($)	Jul. 31, 2024 USD ($) individual
Restructuring Cost and Reserve
One-time severance benefits	$ 2.6
Subsequent Event
Restructuring Cost and Reserve
Number of individuals terminated or notified of their upcoming termination \| individual		35
Percentage of number of individuals terminated or notified of their upcoming termination		69%
Expected one-time severance benefits		$ 5.6

COMMITMENTS AND CONTINGENCIES_2

COMMITMENTS AND CONTINGENCIES (Details)	1 Months Ended
COMMITMENTS AND CONTINGENCIES (Details)	Jan. 31, 2024 USD ($)	Apr. 30, 2022 USD ($) ft²	Aug. 31, 2021 USD ($) ft²
Waltham Lease
Lessee, Lease, Description
Area of land \| ft²			5,000
Operating lease term			39 months
Lease, option to extend	false		true
Renewal term	3 years		3 years
Increase of rental value for square foot	$ 1
Payment for rent			$ 18,000
Lease rent percentage			2%
Foster City Lease
Lessee, Lease, Description
Area of land \| ft²		3,500
Operating lease term		39 months
Renewal term		1 year
Payment for rent		$ 22,600
Lease rent percentage		3%

COMMITMENTS AND CONTINGENCIES -

COMMITMENTS AND CONTINGENCIES - SCHEDULE OF FUTURE MINIMUM ANNUAL LEASE PAYMENTS FOR OPERATING LEASES (Details) - USD ($) $ in Thousands	Jun. 30, 2024	Dec. 31, 2023
COMMITMENTS AND CONTINGENCIES
2024	$ 468
2025	242
Total operating lease payments	710
Less: Amount representing interest	(29)
Present value of net minimum lease payments	681	$ 675
Operating lease liabilities:
Current	475	420
Non-current	206	255
Present value of net minimum lease payments	$ 681	$ 675
Weighted-average remaining lease term (in years)	1 year 4 months 24 days	1 year 6 months
Weighted-average incremental borrowing rate	6.40%	6%

COMMITMENTS AND CONTINGENCIES_3

COMMITMENTS AND CONTINGENCIES - SCHEDULE OF SUPPLEMENTAL CASH FLOW (Details) - USD ($) $ in Thousands	6 Months Ended
	Jun. 30, 2024	Jun. 30, 2023
COMMITMENTS AND CONTINGENCIES
Cash paid included in operating cash flows	$ 254	$ 246

COMMITMENTS AND CONTINGENCIES_4

COMMITMENTS AND CONTINGENCIES - SCHEDULE OF RENT EXPENSES (Details) - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2024	Jun. 30, 2023	Jun. 30, 2024	Jun. 30, 2023
COMMITMENTS AND CONTINGENCIES
Operating lease	$ 114	$ 111	$ 228	$ 221
Short-term lease	83		165
Total rent expense	$ 197	$ 111	$ 393	$ 221

STOCKHOLDERS' EQUITY (Details)

STOCKHOLDERS' EQUITY (Details)	Jun. 30, 2024 Vote $ / shares shares	Dec. 31, 2023 $ / shares shares	Jul. 02, 2021 $ / shares shares
STOCKHOLDERS' EQUITY
Common stock, shares authorized \| shares	150,000,000	150,000,000	150,000,000
Common stock, par value \| $ / shares	$ 0.0001	$ 0.0001	$ 0.0001
Preferred stock, shares authorized \| shares	10,000,000	10,000,000	10,000,000
Preferred stock, par value \| $ / shares	$ 0.0001	$ 0.0001	$ 0.0001
Number of votes for each share of common stock \| Vote	1

STOCKHOLDERS' EQUITY - SCHEDULE

STOCKHOLDERS' EQUITY - SCHEDULE OF COMMON STOCK SHARES RESERVED FOR ON AND AS-CONVERTED BASIS, FOR FUTURE ISSUANCE (Details)	Jun. 30, 2024 shares
Sale of Stock
Common stock reserved for future issuance	7,110,388
Common Stock
Sale of Stock
Common stock reserved for future issuance	5,628,960
Employee Stock Option
Sale of Stock
Common stock reserved for future issuance	1,080,210
Employee stock purchase plan awards
Sale of Stock
Common stock reserved for future issuance	401,218

SHARE-BASED COMPENSATION (Detai

SHARE-BASED COMPENSATION (Details) - USD ($) $ / shares in Units, $ in Thousands		1 Months Ended	6 Months Ended
	Jan. 01, 2023	Jun. 30, 2021	Jun. 30, 2024	Jan. 01, 2024
Share-Based Compensation Arrangement by Share-Based Payment Award
Stock option grants per share			$ 14.92
2021 Stock Option and Incentive Plan
Share-Based Compensation Arrangement by Share-Based Payment Award
Common stock available for issuance			1,080,210
Percentage on total number of shares outstanding			4%
Number of shares authorized			5,675,841	3,075,841
Employee Stock Option \| 2021 Stock Option and Incentive Plan
Share-Based Compensation Arrangement by Share-Based Payment Award
Common stock available for issuance, awards granted			4,520,814
Employee Stock Option \| 2018 Plan
Share-Based Compensation Arrangement by Share-Based Payment Award
Common stock available for issuance, awards granted			1,108,146
Employee Stock Option \| 2021 Plan and 2018 Plan
Share-Based Compensation Arrangement by Share-Based Payment Award
Expiration period			10 years
Unrecognized stock based compensation			$ 31,900
Unrecognized stock-based compensation weighted-average period			2 years 3 months 18 days
Employee Stock Option \| Minimum \| 2021 Plan and 2018 Plan
Share-Based Compensation Arrangement by Share-Based Payment Award
Vested term			3 years
Employee Stock Option \| Maximum \| 2021 Plan and 2018 Plan
Share-Based Compensation Arrangement by Share-Based Payment Award
Vested term			4 years
Restricted stock units
Share-Based Compensation Arrangement by Share-Based Payment Award
Unrecognized stock based compensation			$ 0
Restricted stock units \| 2021 Stock Option and Incentive Plan
Share-Based Compensation Arrangement by Share-Based Payment Award
Restricted stock units award			31,881
Restricted stock units \| Minimum
Share-Based Compensation Arrangement by Share-Based Payment Award
Vested term			3 years
Restricted stock units \| Maximum
Share-Based Compensation Arrangement by Share-Based Payment Award
Vested term			4 years
Employee stock purchase plan awards
Share-Based Compensation Arrangement by Share-Based Payment Award
Percentage on total number of shares outstanding		1%
Number of shares authorized		230,000	401,218
Number of additional shares authorized	247,229
Percentage of common stock purchase price		15%
Offering period		6 months
Discount percentage on marker price		85%
Shares issued			76,011

SHARE-BASED COMPENSATION - SCHE

SHARE-BASED COMPENSATION - SCHEDULE OF OPTION ACTIVITY UNDER 2021 PLAN AND 2018 PLAN (Details) - USD ($) $ / shares in Units, $ in Thousands	6 Months Ended	12 Months Ended
	Jun. 30, 2024	Dec. 31, 2023
SHARE-BASED COMPENSATION
Options Outstanding, beginning balance	5,230,344
Weighted-Average Exercise Price Outstanding, beginning balance	$ 13.66
Weighted- Average Remaining Contractual Term, Outstanding	7 years 7 months 6 days	8 years 1 month 28 days
Aggregate Intrinsic Value Outstanding, beginning balance	$ 49,728
Options Granted	1,489,191
Weighted-Average Exercise Price, Granted	$ 19.70
Options Exercised	(252,521)
Weighted-Average Exercise Price, Exercised	$ 4.82
Options, Cancelled/Forfeited	(838,054)
Weighted-Average Exercise Price, Cancelled/Forfeited	$ 19.95
Options Outstanding, ending balance	5,628,960	5,230,344
Weighted-Average Exercise Price Outstanding, ending balance	$ 14.72	$ 13.66
Aggregate Intrinsic Value Outstanding, ending balance		$ 49,728
Options, Vested and exercisable	2,829,947
Weighted-Average Exercise Price, Vested and exercisable	$ 12.78
Weighted- Average Remaining Contractual Term, Vested and exercisable	6 years 8 months 23 days

SHARE-BASED COMPENSATION - SC_2

SHARE-BASED COMPENSATION - SCHEDULE OF UNVESTED RESTRICTED STOCK UNIT ACTIVITY (Details) - Restricted stock units	6 Months Ended
	Jun. 30, 2024 $ / shares shares
Share-Based Compensation Arrangement by Share-Based Payment Award
Number of units, beginning \| shares	21,968
Weighted Average Grant date fair value, beginning \| $ / shares	$ 22.26
Number of units, Vested \| shares	(5,492)
Weighted Average Grant date fair value, Vested \| $ / shares	$ 21.30
Number of units, forfeited \| shares	(16,476)
Weighted Average Grant date fair value, Forfeited \| $ / shares	$ 22.58

SHARE-BASED COMPENSATION - SC_3

SHARE-BASED COMPENSATION - SCHEDULE OF STOCK-BASED COMPENSATION EXPENSE (Details) - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2024	Jun. 30, 2023	Jun. 30, 2024	Jun. 30, 2023
Share-Based Payment Arrangement, Expensed and Capitalized, Amount
Stock-based compensation expense	$ 3,865	$ 3,034	$ 8,065	$ 5,418
Research and Development Expense
Share-Based Payment Arrangement, Expensed and Capitalized, Amount
Stock-based compensation expense	2,035	1,682	4,529	2,981
General and Administrative Expense
Share-Based Payment Arrangement, Expensed and Capitalized, Amount
Stock-based compensation expense	$ 1,830	$ 1,352	$ 3,536	$ 2,437

SHARE-BASED COMPENSATION - SC_4

SHARE-BASED COMPENSATION - SCHEDULE OF STOCK-BASED COMPENSATION EXPENSE BY TYPE OF AWARDS (Details) - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2024	Jun. 30, 2023	Jun. 30, 2024	Jun. 30, 2023
Share-Based Compensation Arrangement by Share-Based Payment Award
Stock-based compensation expense	$ 3,865	$ 3,034	$ 8,065	$ 5,418
Employee Stock Option
Share-Based Compensation Arrangement by Share-Based Payment Award
Stock-based compensation expense	3,808	2,940	7,876	5,229
Employee stock purchase plan awards
Share-Based Compensation Arrangement by Share-Based Payment Award
Stock-based compensation expense	41	43	127	90
Restricted stock awards and units
Share-Based Compensation Arrangement by Share-Based Payment Award
Stock-based compensation expense	$ 16	$ 51	$ 62	$ 99