Legend Biotech (LEGN) 6-K 20 Nov 23 2023 Q3 Legend Biotech Reports Third Quarter 2023 Results and Recent Highlights Financial data

Cover

Cover	9 Months Ended
	Sep. 30, 2023
Cover [Abstract]
Document Type	6-K
Entity Registrant Name	Legend Biotech Corporation
Entity Central Index Key	0001801198
Document Period End Date	Sep. 30, 2023
Document Fiscal Year Focus	2023
Document Fiscal Period Focus	Q3
Current Fiscal Year End Date	--12-31
Amendment Flag	false

UNAUDITED INTERIM CONDENSED CON

UNAUDITED INTERIM CONDENSED CONSOLIDATED STATEMENTS OF PROFIT OR LOSS AND OTHER COMPREHENSIVE INCOME - USD ($) $ in Thousands	9 Months Ended
	Sep. 30, 2023	Sep. 30, 2022
REVENUE
License revenue	$ 35,172	$ 50,000
Collaboration revenue	170,369	39,236
Other revenue	138	136
Total revenue	205,679	89,372
Collaboration cost of revenue	(111,764)	(42,399)
Other income and gains	49,812	4,693
Research and development expenses	(276,535)	(254,892)
Administrative expenses	(78,062)	(53,950)
Selling and distribution expenses	(60,481)	(67,594)
Other expenses	(231)	(9,496)
Fair value gain/(loss) of warrant liability	(85,750)	30,200
Finance costs	(15,974)	(5,935)
Loss before tax	(373,306)	(310,001)
Income tax benefit/(expense)	(130)	(472)
LOSS FOR THE PERIOD	(373,436)	(310,473)
Attributable to:
Ordinary equity holders of the parent	$ (373,436)	$ (310,473)
LOSS PER SHARE ATTRIBUTABLE TO ORDINARY EQUITY HOLDERS OF THE PARENT
Basic (in dollars per share)	$ (1.07)	$ (990)
Diluted (in dollars per share)	$ (1.07)	$ (990)
OTHER COMPREHENSIVE INCOME
Exchange differences on translation of foreign operations	$ (13,705)	$ 1,143
Net other comprehensive (loss)/ income that may be reclassified to profit or loss in subsequent periods	(13,705)	1,143
OTHER COMPREHENSIVE (LOSS)/ INCOME FOR THE PERIOD, NET OF TAX	(13,705)	1,143
TOTAL COMPREHENSIVE LOSS FOR THE PERIOD	(387,141)	(309,330)
Attributable to:
Ordinary equity holders of the parent	$ (387,141)	$ (309,330)

UNAUDITED INTERIM CONDENSED C_2

UNAUDITED INTERIM CONDENSED CONSOLIDATED STATEMENTS OF FINANCIAL POSITION - USD ($) $ in Thousands	Sep. 30, 2023	Dec. 31, 2022
NON-CURRENT ASSETS
Property, plant and equipment	$ 109,503	$ 105,168
Advance payments for property, plant and equipment	419	914
Right-of-use assets	74,811	55,590
Time deposits	4,268	0
Intangible assets	4,009	3,409
Collaboration prepaid leases	135,997	65,276
Other non-current assets	1,531	1,487
Total non-current assets	330,538	231,844
CURRENT ASSETS
Collaboration inventories	18,014	10,354
Trade receivables	20	90
Prepayments, other receivables and other assets	66,569	61,755
Financial assets at fair value through profit or loss	185,792	185,603
Pledged deposits	356	1,270
Time deposits	274,575	54,016
Cash and cash equivalents	963,470	786,031
Total current assets	1,508,796	1,099,119
Total assets	1,839,334	1,330,963
CURRENT LIABILITIES
Trade payables	17,173	32,893
Other payables and accruals	144,651	184,109
Government grants	630	451
Lease liabilities	2,915	3,563
Tax payable	9,853	9,772
Warrant liability	0	67,000
Total current liabilities	175,222	297,788
NON-CURRENT LIABILITIES
Collaboration interest-bearing advanced funding	275,906	260,932
Lease liabilities long term	41,687	20,039
Government grants	6,764	7,659
Other non-current liabilities	119	233
Total non-current liabilities	324,476	288,863
Total liabilities	499,698	586,651
EQUITY
Share capital	36	33
Reserves	1,339,600	744,279
Total ordinary shareholders’ equity	1,339,636	744,312
Total equity	1,339,636	744,312
Total liabilities and equity	$ 1,839,334	$ 1,330,963

UNAUDITED INTERIM CONDENSED C_3

UNAUDITED INTERIM CONDENSED CONSOLIDATED STATEMENTS OF CHANGES IN EQUITY - USD ($) $ in Thousands	Total	Private Placement for Public Offering	Private Placement for Institutional Investors	Registered Direct Offering	Exercise of Warrant	Share capital	Share capital Private Placement for Public Offering	Share capital Private Placement for Institutional Investors	Share capital Registered Direct Offering	Share capital Exercise of Warrant	Share premium	[1]	Share premium Private Placement for Public Offering	[1]	Share premium Private Placement for Institutional Investors	[1]	Share premium Registered Direct Offering	[1]	Share premium Exercise of Warrant	[1]	Share-based compensation reserves	[1]	Foreign currency translation reserve	[1]	Retained earnings/(accumulated losses)	[1]
Beginning balance at Dec. 31, 2021	$ 765,944					$ 31					$ 1,261,454										$ 19,702		$ 4,864		$ (520,107)
Statement of changes in equity [Roll Forward]
Loss for the period	(310,473)																								(310,473)
Other comprehensive loss:
Exchange differences on translation of foreign operations	1,143																						1,143
TOTAL COMPREHENSIVE LOSS FOR THE PERIOD	(309,330)																						1,143		(310,473)
Issuance of ordinary shares		$ 377,643					$ 2						$ 377,641
Exercise of share options	2,305										3,280										(975)
Reclassification of vested restricted share units	0										12,314										(12,314)
Equity-settled share-based compensation expense	25,365																				25,365
Ending balance at Sep. 30, 2022	861,927					33					1,654,689										31,778		6,007		(830,580)
Beginning balance at Dec. 31, 2022	744,312					33					1,657,015										39,049		14,671		(966,456)
Statement of changes in equity [Roll Forward]
Loss for the period	(373,436)																								(373,436)
Other comprehensive loss:
Exchange differences on translation of foreign operations	(13,705)																						(13,705)
TOTAL COMPREHENSIVE LOSS FOR THE PERIOD	(387,141)																						(13,705)		(373,436)
Issuance of ordinary shares			$ 234,410	$ 349,278	$ 352,491			$ 1	$ 1	$ 1					$ 234,409		$ 349,277		$ 352,490
Exercise of share options	11,195										17,301										(6,106)
Reclassification of vested restricted share units	0										23,421										(23,421)
Equity-settled share-based compensation expense	35,091																				35,091
Ending balance at Sep. 30, 2023	$ 1,339,636					$ 36					$ 2,633,913										$ 44,613		$ 966		$ (1,339,892)
[1]These reserve accounts comprise the consolidated reserves of $1,339.6 million and $861.9 million in the consolidated statements of financial position as at September 30, 2023 and, 2022, respectively

UNAUDITED INTERIM CONDENSED C_4

UNAUDITED INTERIM CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands	9 Months Ended
	Sep. 30, 2023	Sep. 30, 2022
CASH FLOWS USED IN OPERATING ACTIVITIES
Loss before tax	$ (373,306)	$ (310,001)
Adjustments for:
Finance income	(37,185)	(3,293)
Finance costs	15,974	5,935
Depreciation of property, plant and equipment	7,978	7,692
Loss on disposal of property, plant and equipment	223	8
Amortization of intangible assets	1,442	1,621
Depreciation of right-of-use assets	5,680	3,830
Fair value gain/(loss) of warrant liability	85,750	(30,200)
Fair value gains on financial assets measured at fair value through profit or loss	(792)	(102)
Foreign currency exchange loss, net	(10,136)	9,322
Equity-settled share-based compensation expense	35,091	25,365
Deferred government grant	(484)	(234)
Cash flows from (used in) operations before changes in working capital	(269,765)	(290,057)
Decrease in trade receivables	70	50,351
Increase in prepayments, other receivables and other assets	(6,413)	(63,446)
Decrease in other non-current assets	0	895
Increase in collaboration inventories	(7,660)	(8,680)
Government grant received	0	6,521
(Decrease)/increase in trade payables	(15,720)	30,504
(Decrease)/increase in other payables and accruals	(28,784)	117,544
Decrease in other non-current liabilities	(1,243)	(122)
Cash used in operations	(329,515)	(156,490)
Interest income received	32,903	1,801
Income tax received	0	3,709
Interest on lease payments	(1,019)	(559)
Net cash used in operating activities	(297,631)	(151,539)
CASH FLOWS USED IN INVESTING ACTIVITIES
Purchase of property, plant and equipment	(15,739)	(14,374)
Purchase of intangible assets	(134)	(379)
Prepayment to collaborator for collaboration assets	(80,218)	(7,846)
Purchase of financial assets measured at fair value through profit or loss	0	(160,000)
Cash received from withdrawal of financial assets measured at fair value through profit or loss	0	99,990
Cash received from withdrawal of financial assets measured at amortized cost	0	30,000
Cash receipts of investment income	6,402	310
Decrease/(addition) of pledged short-term deposits	922	(400)
Addition in time deposits	(2,948,694)	(369,971)
Decrease in time deposits	2,722,738	320,646
Net cash used in investing activities	(314,723)	(102,024)
CASH FLOWS FROM FINANCING ACTIVITIES
Proceeds from registered direct offering, net of issuance costs	0	0
Proceeds from exercise of warrant by warrant holder, net of issuance cost	199,741	0
Proceeds from issuance of ordinary shares for follow on public offering, net of issuance costs	349,278	377,643
Proceeds from issuance of ordinary shares for institutional investors, net of issuance costs	234,410	0
Proceeds from exercise of share options	11,195	2,305
Principal portion of lease payments	(4,059)	(1,189)
Net cash provided by financing activities	790,565	378,759
NET INCREASE IN CASH AND CASH EQUIVALENTS	178,211	125,196
Effect of foreign exchange rate changes, net	(772)	(1,401)
Cash and cash equivalents at beginning of year	786,031	688,938
CASH AND CASH EQUIVALENTS AT END OF PERIOD	963,470	812,733
ANALYSIS OF BALANCES OF CASH AND CASH EQUIVALENTS
Cash and bank balances	1,242,669	1,031,334
Less: Pledged deposits	356	1,851
Time deposits	278,843	216,750
Cash and cash equivalents as stated in the statement of financial position	963,470	812,733
Cash and cash equivalents as stated in the statement of cash flows	$ 963,470	$ 812,733

UNAUDITED INTERIM CONDENSED C_5

UNAUDITED INTERIM CONDENSED CONSOLIDATED STATEMENTS OF CHANGES IN EQUITY (Parenthetical) - USD ($) $ in Thousands	Sep. 30, 2023	Dec. 31, 2022	Sep. 30, 2022
Statement of changes in equity [abstract]
Reserves	$ 1,339,600	$ 744,279	$ 861,900

Corporate Information

Corporate Information	9 Months Ended
	Sep. 30, 2023
Disclosure of subsidiaries [abstract]
Corporate Information	CORPORATE INFORMATION Legend Biotech Corporation ("Legend") was incorporated on May 27, 2015 as an exempted company in the Cayman Islands with limited liability under the Companies Law of the Cayman Islands. The address of Legend's registered office is PO Box 10240, Harbour Place, 103 South Church Street, George Town, Grant Cayman KY1-1002, Cayman Islands. Legend is an investment holding company. Legend’s subsidiaries are principally engaged in the discovery, development, manufacturing and commercialization of novel cell therapies for oncology and other indications.

Basis of Preparation

Basis of Preparation	9 Months Ended
	Sep. 30, 2023
Basis of Preparation [Abstract]
Basis of Preparation	BASIS OF PREPARATION The unaudited interim condensed consolidated financial statements of Legend and its subsidiaries (collectively referred to as the “Company”) for the nine months ended September 30, 2023 have been prepared in accordance with International Accounting Standard (“IAS”) 34 Interim Financial Reporting (“IAS34”) issued by the International Accounting Standards Board (the “IASB”). The accounting policies and basis of preparation adopted in the preparation of these unaudited interim condensed consolidated financial statements are consistent with those followed in the preparation of the Company financial statements for the year ended December 31, 2022. The Company has not early adopted any other standards, interpretation or amendments that have been issued but are not yet effective. In the opinion of the Company’s management, the accompanying unaudited interim condensed consolidated financial statements contain all normal recurring adjustments necessary to present fairly the financial position, operating results and cash flows of the Company for each of the periods presented. The results of operations for the nine months ended September 30, 2023 are not necessarily indicative of results to be expected for any other interim periods or for the year ended December 31, 2023. The condensed consolidated statement of financial position as of December 31, 2022 was derived from the audited consolidated financial statements at that date but does not include all of the disclosures required by the IASB for annual financial statements. These unaudited interim condensed consolidated financial statements should be read in conjunction with the Company’s audited consolidated financial statements for the year ended December 31, 2022.

New Standards, Interpretations

New Standards, Interpretations and Amendments Adopted by the Company	9 Months Ended
	Sep. 30, 2023
Disclosure of expected impact of initial application of new standards or interpretations [abstract]
New Standards, Interpretations and Amendments Adopted by the Company	NEW STANDARDS, INTERPRETATIONS AND AMENDMENTS ADOPTED BY THE COMPANYThere were no new International Financial Reporting Standards (“IFRS”), amendments or interpretations issued by the IASB that became effective in the nine months ended September 30, 2023 that had a material impact on the Company's unaudited interim condensed consolidated financial statements.

Revenue, Other Income and Gains

Revenue, Other Income and Gains	9 Months Ended
	Sep. 30, 2023
Disclosure of disaggregation of revenue from contracts with customers [abstract]
Revenue, Other Income and Gains	REVENUE, OTHER INCOME AND GAINS An analysis of revenue is as follows: Nine months ended September 30, 2023 2022 US$’000 US$’000 Revenue Licensing of intellectual property 35,172 50,000 Collaboration revenue 170,369 39,236 Other revenue 138 136 Total 205,679 89,372 Revenue from licensing of intellectual property is recognized at a point in time. Revenue from licensing of intellectual property represents variable consideration relating to the milestone payments that were constrained in prior years but included in the transaction price when the achievement of the milestones was highly probable. Collaboration revenue includes our pro-rata share of collaboration net trade sales for which Janssen Biotech, Inc. (“Janssen”) is the principal in the sale to the customer under the collaboration and license agreement with Janssen (the “Janssen Agreement”). Other revenue is related to an exclusive licensing of certain patents to Nanjing Probio Biotech Co., Ltd. and its affiliates and related subsequent sales-based royalties. Nine months ended September 30, 2023 2022 US$’000 US$’000 Other income and gains Other income: Finance income 37,185 3,293 Government grants* 1,528 1,066 Other 5 91 Total income 38,718 4,450 Gains: Foreign currency exchange gain, net 10,136 — Fair value gains on financial assets measured at fair value change through profit or loss 792 112 Other 166 131 Total gains 11,094 243 Total other income and gains 49,812 4,693 ________________________________ * The amount represents subsidies received from local government authorities to support the Company’s business. There were no unfulfilled conditions and other contingencies attached to these government grants.

Loss Before Tax

Loss Before Tax	9 Months Ended
	Sep. 30, 2023
Analysis of income and expense [abstract]
Loss Before Tax	LOSS BEFORE TAX The Company’s loss before tax is arrived at after charging: Nine months ended September 30, 2023 2022 US$’000 US$’000 Employee benefit expense (including directors’ remuneration): Wages and salaries 148,850 104,324 Pension scheme contributions (defined contribution schemes) 5,251 4,333 Equity-settled share-based compensation expense 35,091 25,365

Finance Costs

Finance Costs	9 Months Ended
	Sep. 30, 2023
Finance Costs [Abstract]
Finance Costs	FINANCE COSTS Nine months ended September 30, 2023 2022 US$’000 US$’000 Interest on lease liabilities 1,019 286 Collaboration interest-bearing advanced funding 14,955 5,649 Total 15,974 5,935

Income Tax

Income Tax	9 Months Ended
	Sep. 30, 2023
Major components of tax expense (income) [abstract]
Income Tax	INCOME TAX The Company is subject to income tax on an entity basis on profits arising in or derived from jurisdictions in which Legend or its subsidiaries are domiciled and operate. Cayman Islands Under the current laws of the Cayman Islands, Legend is not subject to tax on income or capital gains. Legend is subject to withholding tax on intercompany notes, which is insignificant. British Virgin Islands Under the current laws of the British Virgin Islands (“BVI”), the subsidiary that operates in BVI is not subject to tax on income or capital gains. Additionally, upon payments of dividends by the Company’s subsidiaries incorporated in BVI to its shareholders, no withholding tax will be imposed. Hong Kong Under the current tax laws of Hong Kong, the subsidiary which operates in Hong Kong is subject to the two-tiered profits tax rates regime. The first HK$2,000,000 (2022: HK$2,000,000) of assessable profits were taxed at 8.25% (2022: 8.25%) and the remaining assessable profits were taxed at 16.5% (2022: 16.5%). Under the Hong Kong tax law, Legend's subsidiary in Hong Kong is exempted from income tax on its foreign derived income and there are no withholding taxes in Hong Kong on remittance of dividends. United States of America Under the current tax laws of the United States, Legend's subsidiary which operates in the United States is subject to federal tax at a rate of 21% (2022: 21%) and a blended state tax rate of 5.4% (2022: 9%). Dividends payable by Legend's subsidiary in the United States, to non-US resident enterprises shall be subject to 30% withholding tax, unless the respective non-US resident enterprise’s jurisdiction of incorporation has a tax treaty or arrangement with the United States that provides for a reduced withholding tax rate or an exemption from withholding tax. Ireland Under the current laws of Ireland, Legend's subsidiary which operates in Ireland is subject to Corporate Income Tax ("CIT") at a rate of 12.5% (2022: 12.5%) on its taxable trading income. Any non-trading income is subject to CIT at a rate of 25% (2022: 25%). Dividend withholding tax is imposed on distributions made by Irish companies at a rate of 25% in 2022 (2022: 25%) with many exemptions provided. Greater China Pursuant to the Corporate Income Tax Law of the People's Republic of China (the "PRC") and the respective regulations (the “CIT Law”), Legend's subsidiaries which operate in the PRC are subject to CIT at a rate of 25% on the taxable income. During the nine months ended September 30, 2023 and 2022, the applicable income tax rate was 25%. Dividends, interests, rent or royalties payable by Legend's PRC subsidiaries, to non-PRC resident enterprises, and proceeds from any such non-resident enterprise investor’s disposition of assets (after deducting the net value of such assets) shall be subject to 10% CIT, namely withholding tax, unless the respective non-PRC resident enterprise’s jurisdiction of incorporation has a tax treaty or arrangements with the PRC that provides for a reduced withholding tax rate or an exemption from withholding tax. Belgium Under the current laws of Belgium, the subsidiary which operates in Belgium is subject to CIT at a rate of 25% on its taxable trading income. Dividend withholding tax is imposed on distributions made by Belgium companies at a rate of 30% with many exemptions provided. Taxes on profits assessable elsewhere have been calculated at the rates of tax prevailing in the jurisdictions in which the Company operates.

Loss per Share Attributable to

Loss per Share Attributable to Ordinary Equity Holders of the Parent	9 Months Ended
	Sep. 30, 2023
Basic earnings per share [abstract]
Loss per Share Attributable to Ordinary Equity Holders of the Parent	LOSS PER SHARE ATTRIBUTABLE TO ORDINARY EQUITY HOLDERS OF THE PARENT The calculation of the basic loss per share amount is based on the loss for the period attributable to ordinary equity holders of Legend Biotech Corporation, and the weighted average number of ordinary shares of 348,293,363 and 314,094,019 in issue during the nine months ended September 30, 2023 and 2022, respectively. The calculation of the diluted earnings per share amount is based on the loss for the period attributable to ordinary equity holders of Legend Biotech Corporation. The weighted average number of ordinary shares used in the calculation is the number of ordinary shares in issue during the period, as used in the basic earnings per share calculation, and the weighted average number of ordinary shares assumed to have been issued at no consideration on the deemed exercise of all potentially dilutive securities into ordinary shares. No adjustment for dilution has been made to the basic loss per share amounts presented for the nine months ended September 30, 2023 and 2022, as the impact of the outstanding share options, restricted share units (the "RSUs"), and warrant liability had an anti-dilutive effect on the basic loss per share amounts presented. The calculations of basic and diluted loss per share are based on: Nine months ended September 30, 2023 2022 US$’000 US$’000 Losses Loss attributable to ordinary equity holders of the parent, used in the basic earnings per share calculation (373,436) (310,473) Number of shares 2023 2022 (Unaudited) (Unaudited) Shares Weighted average number of ordinary shares in issue during the period used in the basic earnings per share calculation 348,293,363 314,094,019

Property, Plant and Equipment

Property, Plant and Equipment	9 Months Ended
	Sep. 30, 2023
Disclosure of detailed information about property, plant and equipment [abstract]
Property, Plant and Equipment	PROPERTY, PLANT AND EQUIPMENT The carrying amounts of the Company’s property, plant and equipment and the movements for the nine months ended September 30, 2023 are as follows: 2023 US$’000 At January 1, 2023 Cost 130,377 Accumulated depreciation (25,209) Net carrying amount 105,168 At January 1, 2023, net of accumulated depreciation 105,168 Additions 14,110 Disposals (153) Depreciation provided during the period (7,978) Exchange realignment (1,644) At September 30, 2023, net of accumulated depreciation 109,503 At September 30, 2023: Cost 141,463 Accumulated depreciation (31,960) Net carrying amount 109,503

Leases

Leases	9 Months Ended
	Sep. 30, 2023
Lease [Abstract]
Leases	LEASES The Company as a lessee The Company has lease contracts for leasehold land, buildings and collaboration assets. Lump sum payments were made upfront to acquire the leasehold land from the owners with lease periods of 50 years, and no ongoing payments will be made under the terms of these leasehold land contracts. Collaboration assets represent the Company’s share of assets leased to the collaboration from Janssen, which purchased the assets on behalf of the collaboration, in connection with the Janssen Agreement. Collaboration assets under construction that will be leased to the collaboration from Janssen when placed into service are classified as collaboration prepaid leases on the condensed consolidated financial statements. Right-of-use assets are depreciated on a straight-line basis over the shorter of the lease terms and the estimated useful lives of the assets. (a) Right-of-use assets The carrying amounts of the Company’s right-of-use assets and the movements for the nine months ended September 30, 2023 are as follows: 2023 US$’000 Right-of-use assets at January 1, 2023 55,590 Additions 25,918 Exchange realignment (1,017) Depreciation of right-of-use assets (5,680) Right-of-use assets at September 30, 2023 74,811 (b) Lease liabilities At the commencement date of the lease, the Company recognizes lease liabilities measured at the present value of lease payments to be made over the lease term. The balance of the Company’s lease liabilities and the movements for the nine months ended September 30, 2023 are as follows: 2023 US$’000 Carrying amount at January 1, 2023 (23,602) Additions (25,925) Accretion of interest recognized during the period (1,013) Payments 5,072 Exchange realignment 866 Carrying amount at September 30, 2023 (44,602) Analyzed into: Current portion (2,915) Non-current portion (41,687) Total (44,602)

Collaboration Inventories

Collaboration Inventories	9 Months Ended
	Sep. 30, 2023
Classes of current inventories [abstract]
Collaboration Inventories	COLLABORATION INVENTORIES September 30, December 31, US$’000 US$’000 Raw materials 11,737 6,989 Work-in-process 2,287 690 Finished goods 3,990 2,675 Total collaboration inventories 18,014 10,354 The Company's reserve for inventory was $6.6 million and $5.3 million as of September 30, 2023 and December 31, 2022, respectively. The Company’s reserve for inventory primarily represented expired material and certain batches or units of product that did not meet quality specifications that were charged to collaboration cost of sales.

Prepayments, Other Receivables

Prepayments, Other Receivables and Other Assets	9 Months Ended
	Sep. 30, 2023
Disclosure Of Prepayments Other Receivables And Other Assets [Abstract]
Prepayments, Other Receivables and Other Assets	PREPAYMENTS, OTHER RECEIVABLES AND OTHER ASSETS September 30, December 31, US$’000 US$’000 Interest receivable — 1,517 Other receivables 48,332 41,324 Lease receivables 99 188 VAT recoverable 1,236 1,396 Prepayments 16,902 17,330 Total 66,569 61,755 None of the above assets are either past due or impaired. The financial assets included in the above balances relate to receivables for which there was no recent history of default. The Company estimated that the expected credit loss for the above receivables as at September 30, 2023 and December 31, 2022 is insignificant.

Cash and Cash Equivalents, Time

Cash and Cash Equivalents, Time Deposits and Pledged Deposits	9 Months Ended
	Sep. 30, 2023
Disclosure Of Cash And Cash Equivalents Time Deposits And Pledged Deposits [Abstract]
Cash and Cash Equivalents, Time Deposits and Pledged Deposits	CASH AND CASH EQUIVALENTS, TIME DEPOSITS AND PLEDGED DEPOSITS September 30, December 31, US$’000 US$’000 Cash and bank balances 1,242,669 841,317 Pledged deposits (356) (1,270) Time deposits (278,843) (54,016) Cash and cash equivalents 963,470 786,031 Denominated in USD 932,371 727,160 Denominated in RMB 13,411 21,472 Denominated in EUR 17,688 37,399 Cash and cash equivalents 963,470 786,031 The cash and cash equivalents of the Company denominated in Renminbi (“RMB”) amounted to $13.4 million and $21.5 million as at September 30, 2023 and December 31, 2022, respectively. The RMB is not freely convertible into other currencies, however, under Greater China Foreign Exchange Control Regulations and Administration of Settlement, Sale and Payment of Foreign Exchange Regulations, the Company is permitted to exchange RMB for other currencies through banks authorized to conduct foreign exchange business. The pledged deposit as at September 30, 2023 and December 31, 2022 was pledged for issuing a letter of guarantee to a supplier of the Company and for credit card facilities.

Other Payables and Accruals

Other Payables and Accruals	9 Months Ended
	Sep. 30, 2023
Disclosure Of Other Payables And Accruals [Abstract]
Other Payables and Accruals	OTHER PAYABLES AND ACCRUALS September 30, December 31, US$’000 US$’000 Accrued payroll 25,189 21,892 Accrued expense 89,581 127,390 Other payables 11,649 10,960 Payable for Collaboration Assets 16,465 22,852 Other tax payables 1,767 1,015 Total 144,651 184,109 Other payables are non-interest-bearing and repayable on demand.

Warrant Liability

Warrant Liability	9 Months Ended
	Sep. 30, 2023
Disclosure of reserves within equity [abstract]
Warrant Liability	WARRANT LIABILITY On May 13, 2021, the Company entered into a subscription agreement with an institutional investor (the “PIPE Investor”) relating to the offer and sale of 20,809,850 ordinary shares of the Company, par value $0.0001 per share (the “ordinary shares”), in a private placement at a purchase price of $14.41625 per ordinary share (the “PIPE Offering”). The total proceeds from the PIPE Offering were $300.0 million. Pursuant to the subscription agreement, the Company also issued to the PIPE Investor, concurrently with the PIPE offering, a warrant (the “Warrant”) exercisable for up to an aggregate of 10,000,000 ordinary shares (such transaction together with the PIPE Offering, the “Transactions”). The Transactions closed on May 21, 2021 (the “Closing Date”). The Warrant was exercisable, in whole or in part, at an exercise price of $20.00 per ordinary share. The Warrant was exercisable after the Closing Date and prior to the two-year anniversary of the Closing Date. On May 11, 2023, the PIPE Investor exercised the Warrant in full for an aggregate exercise price of $200.0 million, and, as a result, the Company issued 10,000,000 ordinary shares to the PIPE Investor. The Warrant was accounted for as a financial liability because the Warrant was net share settleable at the holder’s option. In 2023, up to the exercise of the warrant, the Company recorded a fair value loss of $85.8 million. The movement of the warrant liability is set out as below: Total US$’000 At January 1, 2023 67,000 Fair value loss of the warrant liability 85,750 Exercise of the warrant liability (152,750) At September 30, 2023 —

Collaboration Interest-Bearing

Collaboration Interest-Bearing Advanced Funding	9 Months Ended
	Sep. 30, 2023
Disclosure of detailed information about borrowings [abstract]
Collaboration Interest-Bearing Advanced Funding	COLLABORATION INTEREST-BEARING ADVANCED FUNDING Effective interest rate (%) Maturity September 30, US$’000 Non-current Loans from a collaborator 8.64 No specific maturity date 275,906 Pursuant to the Janssen Agreement, the Company is entitled to receive funding advances from Janssen when certain operational conditions are met. As a result, the Company took an initial funding advance with principal amounting to $17.3 million on June 18, 2021, a second funding advance with principal amounting to $53.1 million on September 17, 2021, a third funding advance with principal amounting to $49.3 million on December 17, 2021, a forth funding advance with principal amounting to $5.3 million on March 18, 2022, a fifth funding advance with principal amounting to $60.9 million on June 17, 2022, a sixth funding advance with principal amounting to $60.5 million on September 16, 2022, and a seventh funding advance with principal amounting to $3.6 million on December 16, 2022, by reducing the same amount of other payables due to Janssen, respectively (collectively, the “Funding Advances”). These Funding Advances are accounted for as interest-bearing borrowings funded by Janssen, constituted by a principal amounting to $250.0 million and applicable interests accrued amounting to $25.9 million upon such principal. The interest rate pursuant to the Janssen Agreement has transitioned in accordance with the LIBOR Act . Thus, outstanding advances accrue interest at 12 month CME term SOFR plus LIBOR/SOFR adjustment (12 month) plus a margin of 2.5%. For each of the seven batches of funding advances, interest started to accrue from June 18, 2021, September 17, 2021, December 17, 2021, March 18, 2022, June 17, 2022, September 16, 2022, and December 16, 2022, respectively Pursuant to the terms of the Janssen Agreement, Janssen may recoup the aggregate amount of Funding Advances, together with interest thereon, from Company’s share of pre-tax profits from the first profitable year of the collaboration program a nd, subject to some limitations, from milestone payments due to the Company under the Janssen Agreement . The Company’s management estimated the loan will not be recouped by Janssen within one year, nor does the Company expect to repay the funding advances within one year, and thus the loan was classified as a long-term liability.

Share Capital and Share Premium

Share Capital and Share Premium	9 Months Ended
	Sep. 30, 2023
Disclosure of classes of share capital [abstract]
Share Capital and Share Premium	SHARE CAPITAL AND SHARE PREMIUM Shares September 30, December 31, US$’000 US$’000 Authorized: 2,000,000,000 ordinary shares of $0.0001 each 200 200 Issued and fully paid: 363,577,853 and 330,134,480 ordinary shares of $0.0001 each 36 33 A summary of movements in the Company’s share capital and share premium is as follows: Number of Share Share Total US$’000 US$’000 US$’000 At December 31, 2022 and January 1, 2023 330,134,480 33 1,657,015 1,657,048 Issuance of ordinary shares for private placements, net of issuance cost 8,834,742 1 234,409 234,410 Issuance of ordinary shares for registered direct offering, net of issuance cost 10,937,500 1 349,277 349,278 Issuance of ordinary shares for exercise of warrants 10,000,000 1 352,490 352,491 Exercise of share option 2,344,228 — 17,301 17,301 Reclassification of vesting of restricted share units 1,326,903 — 23,421 23,421 At September 30, 2023 (Unaudited) 363,577,853 36 2,633,913 2,633,949 On April 24, 2023, May 2, 2023 and May 19, 2023 the Company sold 7,656,968, 484,992 and 692,782 ordinary shares to institutional investors in private placement transactions, respectively, for net proceeds of $234.4 million, after deduction of related issuance costs of $0.4 million. On May 10, 2023, the Company sold 10,937,500 ordinary shares to certain investors in a registered direct offering at a price of $32.00 per share, for net proceeds of $349.3 million, after deduction of related issuance costs of $0.7 million. On May 11, 2023, the PIPE Investor exercised the Warrant in full for an aggregate exercise price of $200.0 million, and, as a result, the Company issued 10,000,000 ordinary shares to the PIPE Investor.

Commitments and Contingencies

Commitments and Contingencies	9 Months Ended
	Sep. 30, 2023
Capital commitments [abstract]
Commitments and Contingencies	COMMITMENTS AND CONTINGENCIES (a) Capital commitments The Company had the following capital commitments as at September 30, 2023: September 30, 2023 (Unaudited) Construction in progress 12,491 (b) Lease contingency We are party to a lease with Janssen under which we expect to lease an approximately 106,000 square foot manufacturing facility from Janssen located in Raritan, New Jersey. That lease will become effective and recorded as a lease on a future date in connection with the Company’s assumption of control of such facility in accordance with the Janssen Agreement . For this facility, which we will collaboratively operate wit h Janssen, we continue to invest in manufacturing, quality, information technology and distribution capabilities to support the launch of CARVYKTI.

Related Party Transactions

Related Party Transactions	9 Months Ended
	Sep. 30, 2023
Disclosure of transactions between related parties [abstract]
Related Party Transactions	RELATED PARTY TRANSACTIONS Company Relationship Genscript Biotech Corporation ("Genscript") The Company’s most significant shareholder Nanjing GenScript Biotech Co., Ltd. (formerly named as Nanjing Jinsirui Biotechnology Co., Ltd.) Controlled by Genscript or its parent, Genscript Corporation Jiangsu GenScript Biotech Co., Ltd. Controlled by Genscript or its parent, Genscript Corporation Genscript USA Incorporated Controlled by Genscript or its parent, Genscript Corporation Genscript USA Holdings Inc Controlled by Genscript or its parent, Genscript Corporation Nanjing Probio Biotech Co., Ltd. Controlled by Genscript or its parent, Genscript Corporation Jiangsu GenScript Probio Biotech Co., Ltd. Controlled by Genscript or its parent, Genscript Corporation Genscript Netherlands Controlled by Genscript or its parent, Genscript Corporation (a) In addition to the transactions detailed elsewhere in the interim unaudited condensed consolidated financial statements, the Company had the following transactions with related parties during the periods presented: (i) Sales-based royalties from related parties: Nine months ended September 30, 2023 2022 US$’000 US$’000 Nanjing Probio Biotech Co., Ltd. 138 136 The sales-based royalties related to the exclusive licensing of certain patents to Nanjing Probio Biotech Co., Ltd and its affiliates. (ii) Purchases from related parties: Nine months ended September 30, 2023 2022 US$’000 US$’000 Nanjing GenScript Biotech Co., Ltd. 3,045 4,938 Genscript USA Incorporated 337 846 Jiangsu GenScript Probio Biotech Co., Ltd 199 1,236 Nanjing Probio Biotech Co., Ltd. 26 219 Jiangsu GenScript Biotech Co., Ltd 1 52 GenScript Probio USA Inc. — 8 Genscript Netherlands — 2 Total 3,608 7,301 The transactions were made according to the price and terms agreed with related parties. (iii) Shared services: During the nine months ended September 30, 2023, no material shared services were provided to the Company by related parties. During the nine months ended September 30, 2022, Nanjing Genscript Biotech Co., Ltd provided certain accounting, legal, IT and administrative shared services to the Company for consideration of $1.5 million. (iv) Lease contract guarantee In 2018, Legend Biotech Ireland Limited ("Legend Ireland") entered into a property lease agreement with a third party in Dublin with lease period from 2018 to August 2028. Genscript provided a guarantee on Legend Ireland’s payment obligations under the lease agreement for nil consideration. (b) Outstanding balances with related parties: The Company had the following significant balances with its related parties at the end of the year: (i) Due from related parties September 30, December 31, US$’000 US$’000 Trade receivables Nanjing Probio Biotech Co., Ltd. 20 90 September 30, December 31, US$’000 US$’000 Other receivables Nanjing GenScript Biotech Co., Ltd. 15 321 Genscript USA Incorporated 16 16 Jiangsu Genscript Biotech Co., Ltd — 3 Total 31 340 September 30, December 31, US$’000 US$’000 Prepayment Nanjing Probio Biotech Co., Ltd. 244 251 Jiangsu GenScript Probio Biotech Co., Ltd — 21 Total 244 272 (ii) Due to related parties September 30, December 31, US$’000 US$’000 Trade payables Nanjing GenScript Biotech Co., Ltd. 311 935 Jiangsu GenScript Biotech Co., Ltd — 93 Genscript USA Incorporated 57 134 Nanjing Probio Biotech Co., Ltd. — 21 Jiangsu Genscript Probio Biotech Co., Ltd 90 — Total 458 1,183 September 30, December 31, US$’000 US$’000 Other payables Nanjing GenScript Biotech Co., Ltd. 1,028 2,435 Jiangsu Genscript Probio Biotech Co., Ltd 115 4 GenScript USA Incorporated. 17 58 Jiangsu Genscript Biotech Co., Ltd 1 7 Nanjing Probio Biotech Co., Limited — 3 Nanjing Bestzyme Bio-Engineering Co., Ltd. 1 — Genscript Netherlands — 1 Total 1,162 2,508 September 30, December 31, US$’000 US$’000 Lease liabilities Genscript USA Holdings Inc 110 427 Nanjing GenScript Biotech Co., Ltd. 152 205 Total 262 632 Except for lease liabilities with incremental borrowing rates between 5.14% and 7.94% repayable over 5 years, all other related party balances are unsecured and repayable on demand and interest free. (iii) Compensation of key management personnel of the Company: Nine months ended September 30, 2023 2022 US$’000 US$’000 Equity-settled share-based compensation expense 4,830 2,675 Short-term employee benefits 2,243 1,595 Total 7,073 4,270

Fair Value and Fair Value Hiera

Fair Value and Fair Value Hierarchy of Financial Instruments	9 Months Ended
	Sep. 30, 2023
Disclosure Of Fair Value Of Financial Instruments [Abstract]
Fair Value and Fair Value Hierarchy of Financial Instruments	FAIR VALUE AND FAIR VALUE HIERARCHY OF FINANCIAL INSTRUMENTS Management has assessed that the fair values of cash and cash equivalents, pledged deposits, time deposits, financial assets included in prepayments, other receivables and other assets, trade receivables, trade payables and financial liabilities included in other payables and accruals approximate to their carrying amounts largely due to the short-term maturities of these instruments. The Company’s finance department, headed by the Corporate Controller, is responsible for determining the policies and procedures for the fair value measurement of financial instruments. The finance department reports directly to the finance manager. At September 30, 2023, the finance department analyzed the movements in the values of financial instruments and determined the major inputs applied in the valuation. The valuation was reviewed and approved by the finance manager. The valuation process and results are discussed with the directors once a year for annual financial reporting. The fair values of the financial assets and liabilities are included at the amount at which the instrument could be exchanged in a current transaction between willing parties, other than in a forced or liquidation sale. The following table illustrates the fair value measurement hierarchy of the Company’s financial instruments: Asset measured at fair value: As at September 30, 2023 (Unaudited) Fair value measurement using Quoted Significant Significant Total US$’000 US$’000 US$’000 US$’000 Financial assets at fair value through profit or loss 185,792 — — 185,792 Financial assets measured at fair value consist of money market funds. During the nine months ended September 30, 2023, there were no transfers of fair value measurements between Level 1 and Level 2 and no transfers into or out of Level 3 for both financial assets and financial liabilities.

Subsequent Event

Subsequent Event	9 Months Ended
	Sep. 30, 2023
Disclosure of non-adjusting events after reporting period [abstract]
Subsequent Event	SUBSEQUENT EVENT On November 10, 2023, Legend Ireland entered into a ("License Agreement") with Novartis Pharma AG (“Novartis”) pursuant to which Legend Ireland granted Novartis an exclusive worldwide license under certain intellectual property rights controlled by Legend Ireland in order to develop, manufacture, commercialize and otherwise exploit certain chimeric antigen receptor T-cell (“CAR-T”) cell therapies targeting Delta-like ligand protein 3, including Legend’s existing autologous CAR-T cell therapy candidate which Legend refers to as “LB2102” ("Licensed Products"). The provisions of the License Agreement, subject to certain customary exceptions, will not become effective until the parties obtain any necessary consents and approvals, including review by the appropriate regulatory agencies under the Hart-Scott-Rodino Antitrust Improvements Act of 1976, as amended (the “Conditions to Effectiveness”). Following the occurrence of the Conditions to Effectiveness, Novartis will be obligated to pay to Legend a $100 million upfront cash payment. In addition, Legend will be eligible to receive from Novartis up to an aggregate of $1.01 billion in milestone payments upon achievement of specified clinical, regulatory and commercial milestones. Legend will also be eligible to receive tiered royalties from the high single digits to the low teens based upon net sales of Licensed Products, subject to certain reductions and offsets. Royalty payments obligations of Novartis continue on a Licensed Product-by-Licensed Product and country-by-country basis, until the latest of: (i) a specified period of time after the first commercial sale of such Licensed Product in such country; (ii) the expiration of the last-to-expire qualifying valid claim of

Approval of the Interim Condens

Approval of the Interim Condensed Consolidated Financial Statements	9 Months Ended
	Sep. 30, 2023
Statement of financial position [abstract]
Approval of the Interim Condensed Consolidated Financial Statements	APPROVAL OF THE INTERIM CONDENSED CONSOLIDATED FINANCIAL STATEMENTS The interim condensed consolidated financial statements were approved and authorized for issue by the Board of Directors on November 20, 2023.

Revenue, Other Income and Gai_2

Revenue, Other Income and Gains (Tables)	9 Months Ended
	Sep. 30, 2023
Disclosure of disaggregation of revenue from contracts with customers [abstract]
Summary of Analysis of Revenue	An analysis of revenue is as follows: Nine months ended September 30, 2023 2022 US$’000 US$’000 Revenue Licensing of intellectual property 35,172 50,000 Collaboration revenue 170,369 39,236 Other revenue 138 136 Total 205,679 89,372
Other Income and Gains	Other revenue is related to an exclusive licensing of certain patents to Nanjing Probio Biotech Co., Ltd. and its affiliates and related subsequent sales-based royalties. Nine months ended September 30, 2023 2022 US$’000 US$’000 Other income and gains Other income: Finance income 37,185 3,293 Government grants* 1,528 1,066 Other 5 91 Total income 38,718 4,450 Gains: Foreign currency exchange gain, net 10,136 — Fair value gains on financial assets measured at fair value change through profit or loss 792 112 Other 166 131 Total gains 11,094 243 Total other income and gains 49,812 4,693 ________________________________ * The amount represents subsidies received from local government authorities to support the Company’s business. There were no unfulfilled conditions and other contingencies attached to these government grants.

Loss Before Tax (Tables)

Loss Before Tax (Tables)	9 Months Ended
	Sep. 30, 2023
Analysis of income and expense [abstract]
Schedule of Profit (Loss) Before Tax Arrived After Charging	The Company’s loss before tax is arrived at after charging: Nine months ended September 30, 2023 2022 US$’000 US$’000 Employee benefit expense (including directors’ remuneration): Wages and salaries 148,850 104,324 Pension scheme contributions (defined contribution schemes) 5,251 4,333 Equity-settled share-based compensation expense 35,091 25,365

Finance Costs (Tables)

Finance Costs (Tables)	9 Months Ended
	Sep. 30, 2023
Finance Costs [Abstract]
Summary of Finance Costs	Nine months ended September 30, 2023 2022 US$’000 US$’000 Interest on lease liabilities 1,019 286 Collaboration interest-bearing advanced funding 14,955 5,649 Total 15,974 5,935

Loss per Share Attributable t_2

Loss per Share Attributable to Ordinary Equity Holders of the Parent (Tables)	9 Months Ended
	Sep. 30, 2023
Basic earnings per share [abstract]
Summary of Calculations of Basic and Diluted Loss per Share	The calculations of basic and diluted loss per share are based on: Nine months ended September 30, 2023 2022 US$’000 US$’000 Losses Loss attributable to ordinary equity holders of the parent, used in the basic earnings per share calculation (373,436) (310,473) Number of shares 2023 2022 (Unaudited) (Unaudited) Shares Weighted average number of ordinary shares in issue during the period used in the basic earnings per share calculation 348,293,363 314,094,019

Property, Plant and Equipment (

Property, Plant and Equipment (Tables)	9 Months Ended
	Sep. 30, 2023
Disclosure of detailed information about property, plant and equipment [abstract]
Schedule of Property, Plant and Equipment	The carrying amounts of the Company’s property, plant and equipment and the movements for the nine months ended September 30, 2023 are as follows: 2023 US$’000 At January 1, 2023 Cost 130,377 Accumulated depreciation (25,209) Net carrying amount 105,168 At January 1, 2023, net of accumulated depreciation 105,168 Additions 14,110 Disposals (153) Depreciation provided during the period (7,978) Exchange realignment (1,644) At September 30, 2023, net of accumulated depreciation 109,503 At September 30, 2023: Cost 141,463 Accumulated depreciation (31,960) Net carrying amount 109,503

Leases (Tables)

Leases (Tables)	9 Months Ended
	Sep. 30, 2023
Lease [Abstract]
Summary of Carrying Amounts of The Right-of-use Assets and Movements	The carrying amounts of the Company’s right-of-use assets and the movements for the nine months ended September 30, 2023 are as follows: 2023 US$’000 Right-of-use assets at January 1, 2023 55,590 Additions 25,918 Exchange realignment (1,017) Depreciation of right-of-use assets (5,680) Right-of-use assets at September 30, 2023 74,811
Summary of Lease Liabilities Measured at Present Value of Lease Payments to be Made Over Lease Term	The balance of the Company’s lease liabilities and the movements for the nine months ended September 30, 2023 are as follows: 2023 US$’000 Carrying amount at January 1, 2023 (23,602) Additions (25,925) Accretion of interest recognized during the period (1,013) Payments 5,072 Exchange realignment 866 Carrying amount at September 30, 2023 (44,602) Analyzed into: Current portion (2,915) Non-current portion (41,687) Total (44,602)

Collaboration Inventories (Tabl

Collaboration Inventories (Tables)	9 Months Ended
	Sep. 30, 2023
Classes of current inventories [abstract]
Summary of Inventories	September 30, December 31, US$’000 US$’000 Raw materials 11,737 6,989 Work-in-process 2,287 690 Finished goods 3,990 2,675 Total collaboration inventories 18,014 10,354

Prepayments, Other Receivable_2

Prepayments, Other Receivables and Other Assets (Tables)	9 Months Ended
	Sep. 30, 2023
Disclosure Of Prepayments Other Receivables And Other Assets [Abstract]
Summary of Prepayments, Other Receivables and Other Assets	September 30, December 31, US$’000 US$’000 Interest receivable — 1,517 Other receivables 48,332 41,324 Lease receivables 99 188 VAT recoverable 1,236 1,396 Prepayments 16,902 17,330 Total 66,569 61,755

Cash and Cash Equivalents, Ti_2

Cash and Cash Equivalents, Time Deposits and Pledged Deposits (Tables)	9 Months Ended
	Sep. 30, 2023
Disclosure Of Cash And Cash Equivalents Time Deposits And Pledged Deposits [Abstract]
Summary of Cash and Cash Equivalents, Time Deposits and Pledged Deposits	September 30, December 31, US$’000 US$’000 Cash and bank balances 1,242,669 841,317 Pledged deposits (356) (1,270) Time deposits (278,843) (54,016) Cash and cash equivalents 963,470 786,031 Denominated in USD 932,371 727,160 Denominated in RMB 13,411 21,472 Denominated in EUR 17,688 37,399 Cash and cash equivalents 963,470 786,031

Other Payables and Accruals (Ta

Other Payables and Accruals (Tables)	9 Months Ended
	Sep. 30, 2023
Disclosure Of Other Payables And Accruals [Abstract]
Summary of Other Payables and Accruals	September 30, December 31, US$’000 US$’000 Accrued payroll 25,189 21,892 Accrued expense 89,581 127,390 Other payables 11,649 10,960 Payable for Collaboration Assets 16,465 22,852 Other tax payables 1,767 1,015 Total 144,651 184,109

Warrant Liability (Tables)

Warrant Liability (Tables)	9 Months Ended
	Sep. 30, 2023
Disclosure of reserves within equity [abstract]
Schedule of Movement of Warrant Liability	The movement of the warrant liability is set out as below: Total US$’000 At January 1, 2023 67,000 Fair value loss of the warrant liability 85,750 Exercise of the warrant liability (152,750) At September 30, 2023 —

Collaboration Interest-Bearin_2

Collaboration Interest-Bearing Advanced Funding (Tables)	9 Months Ended
	Sep. 30, 2023
Disclosure of detailed information about borrowings [abstract]
Summary of Interest-Bearing Loans and Borrowings	Effective interest rate (%) Maturity September 30, US$’000 Non-current Loans from a collaborator 8.64 No specific maturity date 275,906

Share Capital and Share Premi_2

Share Capital and Share Premium (Tables)	9 Months Ended
	Sep. 30, 2023
Disclosure of classes of share capital [abstract]
Summary of Shares	Shares September 30, December 31, US$’000 US$’000 Authorized: 2,000,000,000 ordinary shares of $0.0001 each 200 200 Issued and fully paid: 363,577,853 and 330,134,480 ordinary shares of $0.0001 each 36 33
Summary of Movements in the Company's Share Capital and Share Premium	A summary of movements in the Company’s share capital and share premium is as follows: Number of Share Share Total US$’000 US$’000 US$’000 At December 31, 2022 and January 1, 2023 330,134,480 33 1,657,015 1,657,048 Issuance of ordinary shares for private placements, net of issuance cost 8,834,742 1 234,409 234,410 Issuance of ordinary shares for registered direct offering, net of issuance cost 10,937,500 1 349,277 349,278 Issuance of ordinary shares for exercise of warrants 10,000,000 1 352,490 352,491 Exercise of share option 2,344,228 — 17,301 17,301 Reclassification of vesting of restricted share units 1,326,903 — 23,421 23,421 At September 30, 2023 (Unaudited) 363,577,853 36 2,633,913 2,633,949

Commitments and Contingencies (

Commitments and Contingencies (Tables)	9 Months Ended
	Sep. 30, 2023
Capital commitments [abstract]
Summary of Capital Commitments	The Company had the following capital commitments as at September 30, 2023: September 30, 2023 (Unaudited) Construction in progress 12,491

Related Party Transactions (Tab

Related Party Transactions (Tables)	9 Months Ended
	Sep. 30, 2023
Disclosure of transactions between related parties [abstract]
Summary of Nature of Related Party Relationship	Company Relationship Genscript Biotech Corporation ("Genscript") The Company’s most significant shareholder Nanjing GenScript Biotech Co., Ltd. (formerly named as Nanjing Jinsirui Biotechnology Co., Ltd.) Controlled by Genscript or its parent, Genscript Corporation Jiangsu GenScript Biotech Co., Ltd. Controlled by Genscript or its parent, Genscript Corporation Genscript USA Incorporated Controlled by Genscript or its parent, Genscript Corporation Genscript USA Holdings Inc Controlled by Genscript or its parent, Genscript Corporation Nanjing Probio Biotech Co., Ltd. Controlled by Genscript or its parent, Genscript Corporation Jiangsu GenScript Probio Biotech Co., Ltd. Controlled by Genscript or its parent, Genscript Corporation Genscript Netherlands Controlled by Genscript or its parent, Genscript Corporation
Summary of Transactions with Related Parties	In addition to the transactions detailed elsewhere in the interim unaudited condensed consolidated financial statements, the Company had the following transactions with related parties during the periods presented: (i) Sales-based royalties from related parties: Nine months ended September 30, 2023 2022 US$’000 US$’000 Nanjing Probio Biotech Co., Ltd. 138 136 The sales-based royalties related to the exclusive licensing of certain patents to Nanjing Probio Biotech Co., Ltd and its affiliates. (ii) Purchases from related parties: Nine months ended September 30, 2023 2022 US$’000 US$’000 Nanjing GenScript Biotech Co., Ltd. 3,045 4,938 Genscript USA Incorporated 337 846 Jiangsu GenScript Probio Biotech Co., Ltd 199 1,236 Nanjing Probio Biotech Co., Ltd. 26 219 Jiangsu GenScript Biotech Co., Ltd 1 52 GenScript Probio USA Inc. — 8 Genscript Netherlands — 2 Total 3,608 7,301
Disclosure of Outstanding Balances with Related Parties Explanatory	The Company had the following significant balances with its related parties at the end of the year: (i) Due from related parties September 30, December 31, US$’000 US$’000 Trade receivables Nanjing Probio Biotech Co., Ltd. 20 90 September 30, December 31, US$’000 US$’000 Other receivables Nanjing GenScript Biotech Co., Ltd. 15 321 Genscript USA Incorporated 16 16 Jiangsu Genscript Biotech Co., Ltd — 3 Total 31 340 September 30, December 31, US$’000 US$’000 Prepayment Nanjing Probio Biotech Co., Ltd. 244 251 Jiangsu GenScript Probio Biotech Co., Ltd — 21 Total 244 272 (ii) Due to related parties September 30, December 31, US$’000 US$’000 Trade payables Nanjing GenScript Biotech Co., Ltd. 311 935 Jiangsu GenScript Biotech Co., Ltd — 93 Genscript USA Incorporated 57 134 Nanjing Probio Biotech Co., Ltd. — 21 Jiangsu Genscript Probio Biotech Co., Ltd 90 — Total 458 1,183 September 30, December 31, US$’000 US$’000 Other payables Nanjing GenScript Biotech Co., Ltd. 1,028 2,435 Jiangsu Genscript Probio Biotech Co., Ltd 115 4 GenScript USA Incorporated. 17 58 Jiangsu Genscript Biotech Co., Ltd 1 7 Nanjing Probio Biotech Co., Limited — 3 Nanjing Bestzyme Bio-Engineering Co., Ltd. 1 — Genscript Netherlands — 1 Total 1,162 2,508 September 30, December 31, US$’000 US$’000 Lease liabilities Genscript USA Holdings Inc 110 427 Nanjing GenScript Biotech Co., Ltd. 152 205 Total 262 632
Summary of Compensation of Key Management Personnel	Compensation of key management personnel of the Company: Nine months ended September 30, 2023 2022 US$’000 US$’000 Equity-settled share-based compensation expense 4,830 2,675 Short-term employee benefits 2,243 1,595 Total 7,073 4,270

Fair Value and Fair Value Hie_2

Fair Value and Fair Value Hierarchy of Financial Instruments (Tables)	9 Months Ended
	Sep. 30, 2023
Disclosure Of Fair Value Of Financial Instruments [Abstract]
Summary of Assets Measured at Fair Value	Asset measured at fair value: As at September 30, 2023 (Unaudited) Fair value measurement using Quoted Significant Significant Total US$’000 US$’000 US$’000 US$’000 Financial assets at fair value through profit or loss 185,792 — — 185,792

Revenue, Other Income and Gai_3

Revenue, Other Income and Gains - Summary of Analysis of Revenue (Details) - USD ($) $ in Thousands	9 Months Ended
	Sep. 30, 2023	Sep. 30, 2022
Revenue
Licensing of intellectual property	$ 35,172	$ 50,000
Collaboration revenue	170,369	39,236
Other revenue	138	136
Total revenue	$ 205,679	$ 89,372

Revenue, Other Income and Gai_4

Revenue, Other Income and Gains - Other Income and Gains (Details) - USD ($) $ in Thousands	9 Months Ended
	Sep. 30, 2023	Sep. 30, 2022
Other income:
Finance income	$ 37,185	$ 3,293
Government grants	1,528	1,066
Other	5	91
Total income	38,718	4,450
Gains:
Foreign currency exchange gain, net	10,136	0
Fair value gains on financial assets measured at fair value change through profit or loss	792	112
Other	166	131
Total gains	11,094	243
Total other income and gains	$ 49,812	$ 4,693

Loss Before Tax (Details)

Loss Before Tax (Details) - USD ($) $ in Thousands	9 Months Ended
	Sep. 30, 2023	Sep. 30, 2022
Employee benefit expense (including directors’ remuneration):
Equity-settled share-based compensation expense	$ 35,091	$ 25,365
Profit Loss Before Tax Arrived After Charging And Crediting
Employee benefit expense (including directors’ remuneration):
Wages and salaries	148,850	104,324
Pension scheme contributions (defined contribution schemes)	5,251	4,333
Equity-settled share-based compensation expense	$ 35,091	$ 25,365

Finance Costs (Details)

Finance Costs (Details) - USD ($) $ in Thousands	9 Months Ended
	Sep. 30, 2023	Sep. 30, 2022
Finance Costs [Abstract]
Interest on lease liabilities	$ 1,019	$ 286
Collaboration interest-bearing advanced funding	14,955	5,649
Total	$ 15,974	$ 5,935

Income Tax (Details)

Income Tax (Details) $ in Thousands, $ in Millions	9 Months Ended
	Sep. 30, 2023 USD ($)	Sep. 30, 2023 HKD ($)	Sep. 30, 2022 USD ($)	Sep. 30, 2022 HKD ($)
Major Components Of Tax Expense Income [Line Items]
Income tax expense	$ 130		$ 472
Hong Kong
Major Components Of Tax Expense Income [Line Items]
Taxable income		$ 2		$ 2
Income tax rate	8.25%	8.25%	8.25%	8.25%
Income tax rate on remaining assessable profits	16.50%	16.50%	16.50%	16.50%
United States
Major Components Of Tax Expense Income [Line Items]
Income tax rate	21%	21%	21%	21%
Withholding tax rate	30%	30%
New Jersey
Major Components Of Tax Expense Income [Line Items]
Income tax rate	5.40%	5.40%	9%	9%
Ireland
Major Components Of Tax Expense Income [Line Items]
Income tax rate	12.50%	12.50%	12.50%	12.50%
Withholding tax rate	25%	25%	25%	25%
Non-trading income tax rate	25%	25%	25%	25%
China
Major Components Of Tax Expense Income [Line Items]
Income tax rate	25%	25%	25%	25%
Withholding tax rate	10%	10%
Belgium
Major Components Of Tax Expense Income [Line Items]
Income tax rate	25%	25%
Withholding tax rate	30%	30%

Loss per Share Attributable t_3

Loss per Share Attributable to Ordinary Equity Holders of the Parent - Additional Information (Details) - shares	9 Months Ended
	Sep. 30, 2023	Sep. 30, 2022
Basic earnings per share [abstract]
Weighted average number of ordinary shares in issue during the period used in the basic earnings per share calculation (in shares)	348,293,363	314,094,019

Loss per Share Attributable t_4

Loss per Share Attributable to Ordinary Equity Holders of the Parent - Summary of Calculations of Basic and Diluted Loss per Share (Details) - USD ($) $ in Thousands	9 Months Ended
	Sep. 30, 2023	Sep. 30, 2022
Basic earnings per share [abstract]
Loss attributable to ordinary equity holders of the parent, used in the basic earnings per share calculation	$ (373,436)	$ (310,473)
Weighted average number of ordinary shares in issue during the period used in the basic earnings per share calculation (in shares)	348,293,363	314,094,019

Property, Plant and Equipment_2

Property, Plant and Equipment (Details) $ in Thousands	9 Months Ended
	Sep. 30, 2023 USD ($)
Property, Plant and Equipment [Roll Forward]
Property, plant and equipment, beginning balance	$ 105,168
Additions	14,110
Disposals	(153)
Depreciation provided during the period	(7,978)
Exchange realignment	(1,644)
Property, plant and equipment, ending balance	109,503
Cost
Property, Plant and Equipment [Roll Forward]
Property, plant and equipment, beginning balance	130,377
Property, plant and equipment, ending balance	141,463
Accumulated depreciation
Property, Plant and Equipment [Roll Forward]
Property, plant and equipment, beginning balance	(25,209)
Property, plant and equipment, ending balance	$ (31,960)

Leases - Additional Information

Leases - Additional Information (Details) - Leasehold land $ in Millions	9 Months Ended
	Sep. 30, 2023 USD ($)
Leases [Line Items]
Lessee, lease terms	50 years
Ongoing lease payments	$ 0

Leases - Summary of Carrying Am

Leases - Summary of Carrying Amounts of The Right-of-use Assets and Movements (Details) $ in Thousands	9 Months Ended
	Sep. 30, 2023 USD ($)
Right-of-Use Assets [Roll Forward]
Beginning balance	$ 55,590
Additions	25,918
Exchange realignment	(1,017)
Depreciation of right-of-use assets	(5,680)
Ending balance	$ 74,811

Leases - Summary of Lease Liabi

Leases - Summary of Lease Liabilities Measured at Present Value of Lease Payments to be Made Over Lease Term (Details) - USD ($) $ in Thousands	9 Months Ended
	Sep. 30, 2023	Dec. 31, 2022
Analyzed into:
Current portion	$ (2,915)	$ (3,563)
Non-current portion	(41,687)	(20,039)
Lease liabilities
Leases [Roll Forward]
Carrying amount at January 1, 2023	(23,602)
Additions	(25,925)
Accretion of interest recognized during the period	(1,013)
Payments	5,072
Exchange realignment	866
Carrying amount at September 30, 2023	(44,602)
Analyzed into:
Current portion	(2,915)
Non-current portion	(41,687)
Total	$ (44,602)	$ (23,602)

Collaboration Inventories - Sum

Collaboration Inventories - Summary of Inventories (Details) - USD ($) $ in Thousands	Sep. 30, 2023	Dec. 31, 2022
Classes of current inventories [abstract]
Raw materials	$ 11,737	$ 6,989
Work-in-process	2,287	690
Finished goods	3,990	2,675
Total collaboration inventories	$ 18,014	$ 10,354

Collaboration Inventories - Add

Collaboration Inventories - Additional Information (Details) - USD ($) $ in Millions	Sep. 30, 2023	Dec. 31, 2022
Classes of current inventories [abstract]
Inventory reserve	$ 6.6	$ 5.3

Prepayments, Other Receivable_3

Prepayments, Other Receivables and Other Assets (Details) - Prepayments Other Receivable and Other Assets - USD ($) $ in Thousands	Sep. 30, 2023	Dec. 31, 2022
Disclosure Of Prepayments Other Receivables And Other Assets [Line Items]
Interest receivable	$ 0	$ 1,517
Other receivables	48,332	41,324
Lease receivables	99	188
VAT recoverable	1,236	1,396
Prepayments	16,902	17,330
Total	$ 66,569	$ 61,755

Cash and Cash Equivalents, Ti_3

Cash and Cash Equivalents, Time Deposits and Pledged Deposits - Summary of Cash and Cash Equivalents and Pledged Deposits (Details) - USD ($) $ in Thousands	Sep. 30, 2023	Dec. 31, 2022	Sep. 30, 2022	Dec. 31, 2021
Disclosure Of Cash And Cash Equivalents Time Deposits And Pledged Deposits [Line Items]
Cash and bank balances	$ 1,242,669	$ 841,317
Pledged deposits	(356)	(1,270)
Time deposits	(278,843)	(54,016)
Cash and cash equivalents	963,470	786,031	$ 812,733	$ 688,938
Denominated in USD
Disclosure Of Cash And Cash Equivalents Time Deposits And Pledged Deposits [Line Items]
Cash and cash equivalents	932,371	727,160
Denominated in RMB
Disclosure Of Cash And Cash Equivalents Time Deposits And Pledged Deposits [Line Items]
Cash and bank balances	13,400	21,500
Cash and cash equivalents	13,411	21,472
Denominated in EUR
Disclosure Of Cash And Cash Equivalents Time Deposits And Pledged Deposits [Line Items]
Cash and cash equivalents	$ 17,688	$ 37,399

Cash and Cash Equivalents, Ti_4

Cash and Cash Equivalents, Time Deposits and Pledged Deposits - Additional Information (Details) - USD ($) $ in Thousands	Sep. 30, 2023	Dec. 31, 2022
Disclosure Of Cash And Cash Equivalents Time Deposits And Pledged Deposits [Line Items]
Cash and cash equivalents	$ 1,242,669	$ 841,317
Denominated in RMB
Disclosure Of Cash And Cash Equivalents Time Deposits And Pledged Deposits [Line Items]
Cash and cash equivalents	$ 13,400	$ 21,500

Other Payables and Accruals (De

Other Payables and Accruals (Details) - USD ($) $ in Thousands	Sep. 30, 2023	Dec. 31, 2022
Disclosure Of Other Payables And Accruals [Abstract]
Accrued payroll	$ 25,189	$ 21,892
Accrued expense	89,581	127,390
Other payables	11,649	10,960
Payable for Collaboration Assets	16,465	22,852
Other tax payables	1,767	1,015
Total	$ 144,651	$ 184,109

Warrant Liability - Additional

Warrant Liability - Additional Information (Details) - USD ($) $ / shares in Units, $ in Thousands			9 Months Ended
	May 11, 2023	May 13, 2021	Sep. 30, 2023	Dec. 31, 2022
Number of shares issued (in shares)		20,809,850
Price per share (in dollars per share)		$ 0.0001
Private placement purchase price per share (in dollars per share)		$ 14.41625
Aggregate exercise price of warrants		$ 300,000
Aggregate exercise price of warrant	$ 200,000
Fair value loss of warrant liability			$ 85,750
Ordinary Shares
Number of shares issued (in shares)	10,000,000
Price per share (in dollars per share)			$ 0.0001	$ 0.0001
Warrant
Number of shares issued (in shares)		10,000,000
Private placement purchase price per share (in dollars per share)		$ 20

Warrant Liability - Schedule of

Warrant Liability - Schedule of Movement of Warrant Liability (Details) $ in Thousands	9 Months Ended
	Sep. 30, 2023 USD ($)
Warranty Liabilities [Roll Forward]
Balance, beginning of the period	$ 67,000
Fair value loss of the warrant liability	85,750
Exercise of the warrant liability	(152,750)
Balance, end of the period	$ 0

Collaboration Interest-Bearin_3

Collaboration Interest-Bearing Advanced Funding - Summary of Interest-Bearing Loans and Borrowings (Details) - 11.0% Interest Bearing Loans $ in Thousands	9 Months Ended
	Sep. 30, 2023 USD ($)
Disclosure Of Detailed Information About Borrowings [Line Items]
Effective interest rate (%)	8.64%
Maturity	No specific maturity date
Loans from a collaborator	$ 275,906

Collaboration Interest-Bearin_4

Collaboration Interest-Bearing Advanced Funding - Additional Information (Details) - USD ($) $ in Millions	9 Months Ended
	Sep. 30, 2023	Dec. 16, 2022	Sep. 16, 2022	Jun. 17, 2022	Mar. 18, 2022	Dec. 17, 2021	Sep. 17, 2021	Jun. 18, 2021
Disclosure of detailed information about borrowings [abstract]
Funding advances from collaborator principal amount	$ 250	$ 3.6	$ 60.5	$ 60.9	$ 5.3	$ 49.3	$ 53.1	$ 17.3
Interest bearing borrowings funded interests accrued	$ 25.9
Interest rate margin (percent)	2.50%

Share Capital and Share Premi_3

Share Capital and Share Premium - Summary of Shares (Details) - USD ($) $ / shares in Units, $ in Thousands	Sep. 30, 2023	Dec. 31, 2022	May 13, 2021
Authorized:
Price per share (in dollars per share)			$ 0.0001
Issued and fully paid:
Price per share (in dollars per share)			$ 0.0001
363,577,853 and 330,134,480 ordinary shares of $0.0001 each	$ 36	$ 33
Ordinary Shares
Authorized:
Ordinary shares authorized (in shares)	2,000,000,000	2,000,000,000
Price per share (in dollars per share)	$ 0.0001	$ 0.0001
2,000,000,000 ordinary shares of $0.0001 each	$ 200	$ 200
Issued and fully paid:
Ordinary shares issued and fully paid (in shares)	363,577,853	330,134,480
Price per share (in dollars per share)	$ 0.0001	$ 0.0001
363,577,853 and 330,134,480 ordinary shares of $0.0001 each	$ 36	$ 33

Share Capital and Share Premi_4

Share Capital and Share Premium - Summary of Movements in the Company's Share Capital and Share Premium (Details) $ in Thousands	9 Months Ended
	Sep. 30, 2023 USD ($) shares
Share Capital [Roll Forward]
Beginning balance	$ 1,657,048
Issuance of ordinary shares for private placements, net of issuance cost	234,410
Issuance of ordinary shares for registered direct offering, net of issuance cost	349,278
Issuance of ordinary shares for exercise of warrants	352,491
Exercise of share option	17,301
Reclassification of vesting of restricted share units	23,421
Ending balance	$ 2,633,949
Number of shares in issue
Share Capital [Roll Forward]
Beginning balance (in shares) | shares	330,134,480
Issuance of ordinary shares for private placements, net of issuance cost (in shares) | shares	8,834,742
Issuance of ordinary shares for registered direct offering, net of issuance cost (in shares) | shares	10,937,500
Issuance of ordinary shares for exercise of warrants (in shares) | shares	10,000,000
Exercise of share option (in shares) | shares	2,344,228
Reclassification of vesting of restricted share units (in shares) | shares	1,326,903
Ending balance (in shares) | shares	363,577,853
Share capital
Share Capital [Roll Forward]
Beginning balance	$ 33
Issuance of ordinary shares for private placements, net of issuance cost	1
Issuance of ordinary shares for registered direct offering, net of issuance cost	1
Issuance of ordinary shares for exercise of warrants	1
Exercise of share option	0
Reclassification of vesting of restricted share units	0
Ending balance	36
Share premium
Share Capital [Roll Forward]
Beginning balance	1,657,015
Issuance of ordinary shares for private placements, net of issuance cost	234,409
Issuance of ordinary shares for registered direct offering, net of issuance cost	349,277
Issuance of ordinary shares for exercise of warrants	352,490
Exercise of share option	17,301
Reclassification of vesting of restricted share units	23,421
Ending balance	$ 2,633,913

Share Capital and Share Premi_5

Share Capital and Share Premium - Additional Information (Details) - USD ($) $ / shares in Units, $ in Millions			1 Months Ended
	May 11, 2023	May 10, 2023	May 19, 2023	Sep. 30, 2023	May 02, 2023	Apr. 24, 2023	Dec. 31, 2022	May 13, 2021
Disclosure Of Classes Of Share Capital [Line Items]
Number of shares issued (in shares)								20,809,850
Price per share (in dollars per share)								$ 0.0001
Aggregate exercise price of warrant	$ 200
Exercise of Warrant
Disclosure Of Classes Of Share Capital [Line Items]
Aggregate exercise price of warrant	$ 200
Ordinary Shares
Disclosure Of Classes Of Share Capital [Line Items]
Number of shares issued (in shares)	10,000,000
Price per share (in dollars per share)				$ 0.0001			$ 0.0001
Ordinary Shares | Private Placement Transactions
Disclosure Of Classes Of Share Capital [Line Items]
Number of shares issued (in shares)			692,782		484,992	7,656,968
Proceeds from issuance of ordinary shares for initial public offering, net of issuance costs			$ 234.4
Issuance costs			$ 0.4
Ordinary Shares | Registered Direct Offering
Disclosure Of Classes Of Share Capital [Line Items]
Number of shares issued (in shares)		10,937,500
Proceeds from issuance of ordinary shares for initial public offering, net of issuance costs		$ 349.3
Issuance costs		$ 0.7
Price per share (in dollars per share)		$ 32
Ordinary Shares | Exercise of Warrant
Disclosure Of Classes Of Share Capital [Line Items]
Number of shares issued (in shares)	10,000,000

Commitments and Contingencies -

Commitments and Contingencies - Summary of Capital Commitments (Details) $ in Thousands	Sep. 30, 2023 USD ($)
Capital commitments [abstract]
Construction in progress	$ 12,491

Commitments and Contingencies_2

Commitments and Contingencies - Additional Information (Details) ft² in Thousands	Sep. 30, 2023 ft²
Capital commitments [abstract]
Area of manufacturing facility expected to be leased (in square feet)	106

Related Party Transactions - Su

Related Party Transactions - Summary of Nature of Related Party Relationship (Details)	9 Months Ended
	Sep. 30, 2023
Genscript Biotech Corporation ("Genscript")
Disclosure Of Transactions Between Related Parties [Line Items]
Relationship	The Company’s most significant shareholder
Nanjing GenScript Biotech Co., Ltd. (formerly named as Nanjing Jinsirui Biotechnology Co., Ltd.)
Disclosure Of Transactions Between Related Parties [Line Items]
Relationship	Controlled by Genscript or its parent, Genscript Corporation
Jiangsu GenScript Biotech Co., Ltd.
Disclosure Of Transactions Between Related Parties [Line Items]
Relationship	Controlled by Genscript or its parent, Genscript Corporation
Genscript USA Incorporated
Disclosure Of Transactions Between Related Parties [Line Items]
Relationship	Controlled by Genscript or its parent, Genscript Corporation
Genscript USA Holdings Inc
Disclosure Of Transactions Between Related Parties [Line Items]
Relationship	Controlled by Genscript or its parent, Genscript Corporation
Nanjing Probio Biotech Co., Ltd.
Disclosure Of Transactions Between Related Parties [Line Items]
Relationship	Controlled by Genscript or its parent, Genscript Corporation
Jiangsu GenScript Probio Biotech Co., Ltd.
Disclosure Of Transactions Between Related Parties [Line Items]
Relationship	Controlled by Genscript or its parent, Genscript Corporation
Genscript Netherlands
Disclosure Of Transactions Between Related Parties [Line Items]
Relationship	Controlled by Genscript or its parent, Genscript Corporation

Related Party Transactions - _2

Related Party Transactions - Summary of Transactions with Related Parties (Details) - USD ($) $ in Thousands	9 Months Ended
	Sep. 30, 2023	Sep. 30, 2022
Disclosure Of Transactions Between Related Parties [Line Items]
Purchases from related parties	$ 3,608	$ 7,301
Nanjing Probio Biotech Co., Ltd.
Disclosure Of Transactions Between Related Parties [Line Items]
Sales-based royalties from related parties	138	136
Purchases from related parties	26	219
Nanjing GenScript Biotech Co., Ltd.
Disclosure Of Transactions Between Related Parties [Line Items]
Purchases from related parties	3,045	4,938
Genscript USA Incorporated
Disclosure Of Transactions Between Related Parties [Line Items]
Purchases from related parties	337	846
Jiangsu GenScript Probio Biotech Co., Ltd.
Disclosure Of Transactions Between Related Parties [Line Items]
Purchases from related parties	199	1,236
Jiangsu GenScript Biotech Co., Ltd.
Disclosure Of Transactions Between Related Parties [Line Items]
Purchases from related parties	1	52
GenScript Probio USA Inc.
Disclosure Of Transactions Between Related Parties [Line Items]
Purchases from related parties	0	8
Genscript Netherlands
Disclosure Of Transactions Between Related Parties [Line Items]
Purchases from related parties	$ 0	$ 2

Related Party Transactions - Ad

Related Party Transactions - Additional Information (Details) - USD ($) $ in Millions	9 Months Ended
	Sep. 30, 2023	Sep. 30, 2022
Bottom of Range
Disclosure Of Transactions Between Related Parties [Line Items]
Lessee's incremental borrowing rate applied to lease liabilities	5.14%
Lease liabilities, repayment term	5 years
Top of Range
Disclosure Of Transactions Between Related Parties [Line Items]
Lessee's incremental borrowing rate applied to lease liabilities	7.94%
Nanjing GenScript Biotech Co., Ltd.
Disclosure Of Transactions Between Related Parties [Line Items]
Consideration paid for shared services	$ 0	$ 1.5

Related Party Transactions - _3

Related Party Transactions - Summary of Outstanding Balances with Related Parties (Details) - USD ($) $ in Thousands	Sep. 30, 2023	Dec. 31, 2022
Lease liabilities
Disclosure Of Transactions Between Related Parties [Line Items]
Due to related parties	$ 262	$ 632
Other receivables
Disclosure Of Transactions Between Related Parties [Line Items]
Other receivables due from related parties	31	340
Prepayment
Disclosure Of Transactions Between Related Parties [Line Items]
Other receivables due from related parties	244	272
Trade payables
Disclosure Of Transactions Between Related Parties [Line Items]
Due to related parties	458	1,183
Other payables
Disclosure Of Transactions Between Related Parties [Line Items]
Due to related parties	1,162	2,508
Nanjing Probio Biotech Co., Ltd. | Trade receivables
Disclosure Of Transactions Between Related Parties [Line Items]
Other receivables due from related parties	20	90
Nanjing Probio Biotech Co., Ltd. | Prepayment
Disclosure Of Transactions Between Related Parties [Line Items]
Other receivables due from related parties	244	251
Nanjing Probio Biotech Co., Ltd. | Trade payables
Disclosure Of Transactions Between Related Parties [Line Items]
Due to related parties	0	21
Nanjing Probio Biotech Co., Ltd. | Other payables
Disclosure Of Transactions Between Related Parties [Line Items]
Due to related parties	0	3
Nanjing GenScript Biotech Co., Ltd. | Lease liabilities
Disclosure Of Transactions Between Related Parties [Line Items]
Due to related parties	152	205
Nanjing GenScript Biotech Co., Ltd. | Other receivables
Disclosure Of Transactions Between Related Parties [Line Items]
Other receivables due from related parties	15	321
Nanjing GenScript Biotech Co., Ltd. | Trade payables
Disclosure Of Transactions Between Related Parties [Line Items]
Due to related parties	311	935
Nanjing GenScript Biotech Co., Ltd. | Other payables
Disclosure Of Transactions Between Related Parties [Line Items]
Due to related parties	1,028	2,435
Genscript USA Incorporated | Other receivables
Disclosure Of Transactions Between Related Parties [Line Items]
Other receivables due from related parties	16	16
Genscript USA Incorporated | Trade payables
Disclosure Of Transactions Between Related Parties [Line Items]
Due to related parties	57	134
Genscript USA Incorporated | Other payables
Disclosure Of Transactions Between Related Parties [Line Items]
Due to related parties	17	58
Jiangsu GenScript Biotech Co., Ltd. | Other receivables
Disclosure Of Transactions Between Related Parties [Line Items]
Other receivables due from related parties	0	3
Jiangsu GenScript Biotech Co., Ltd. | Trade payables
Disclosure Of Transactions Between Related Parties [Line Items]
Due to related parties	0	93
Jiangsu GenScript Biotech Co., Ltd. | Other payables
Disclosure Of Transactions Between Related Parties [Line Items]
Due to related parties	1	7
Jiangsu GenScript Probio Biotech Co., Ltd. | Prepayment
Disclosure Of Transactions Between Related Parties [Line Items]
Other receivables due from related parties	0	21
Jiangsu GenScript Probio Biotech Co., Ltd. | Trade payables
Disclosure Of Transactions Between Related Parties [Line Items]
Due to related parties	90	0
Jiangsu GenScript Probio Biotech Co., Ltd. | Other payables
Disclosure Of Transactions Between Related Parties [Line Items]
Due to related parties	115	4
Nanjing Bestzyme Bio-Engineering Co., Ltd. | Other payables
Disclosure Of Transactions Between Related Parties [Line Items]
Due to related parties	1	0
Genscript Netherlands | Other payables
Disclosure Of Transactions Between Related Parties [Line Items]
Due to related parties	0	1
Genscript USA Holdings Inc | Lease liabilities
Disclosure Of Transactions Between Related Parties [Line Items]
Due to related parties	$ 110	$ 427

Related Party Transactions - _4

Related Party Transactions - Summary of Compensation of Key Management Personnel (Details) - USD ($) $ in Thousands	9 Months Ended
	Sep. 30, 2023	Sep. 30, 2022
Disclosure of transactions between related parties [abstract]
Equity-settled share-based compensation expense	$ 4,830	$ 2,675
Short-term employee benefits	2,243	1,595
Total	$ 7,073	$ 4,270

Fair Value and Fair Value Hie_3

Fair Value and Fair Value Hierarchy of Financial Instruments (Details) - USD ($) $ in Thousands	Sep. 30, 2023	Dec. 31, 2022
Disclosure Fair Value Measurement Hierarchy Of Financial Instruments [Line Items]
Financial assets at fair value through profit or loss	$ 185,792	$ 185,603
Quoted prices in active markets (Level 1)
Disclosure Fair Value Measurement Hierarchy Of Financial Instruments [Line Items]
Financial assets at fair value through profit or loss	185,792
Significant observable inputs (Level 2)
Disclosure Fair Value Measurement Hierarchy Of Financial Instruments [Line Items]
Financial assets at fair value through profit or loss	0
Significant unobservable inputs (Level 3)
Disclosure Fair Value Measurement Hierarchy Of Financial Instruments [Line Items]
Financial assets at fair value through profit or loss	$ 0

Subsequent Event (Details)

Subsequent Event (Details) - Novartis Agreement - License Agreement $ in Millions	Nov. 10, 2023 USD ($)
Disclosure of non-adjusting events after reporting period [line items]
Expected upfront cash payment	$ 100
Expected milestone payments receivable	$ 1,010