Applied Molecular Transport (AMTI) 10-Q 14 Aug 23 2023 Q2 Quarterly report Financial data

Cover

Cover - shares	6 Months Ended
	Jun. 30, 2023	Aug. 03, 2023
Entity Addresses [Line Items]
Document Type	10-Q
Document Quarterly Report	true
Document Period End Date	Jun. 30, 2023
Document Transition Report	false
Entity File Number	001-39306
Entity Registrant Name	APPLIED MOLECULAR TRANSPORT INC.
Entity Incorporation, State or Country Code	DE
Entity Tax Identification Number	81-4481426
City Area Code	650
Local Phone Number	392-0420
Title of 12(b) Security	Common Stock, par value $0.0001 per share
Trading Symbol	AMTI
Security Exchange Name	NASDAQ
Entity Current Reporting Status	Yes
Entity Interactive Data Current	Yes
Entity Filer Category	Non-accelerated Filer
Entity Small Business	true
Entity Emerging Growth Company	false
Entity Shell Company	false
Entity Common Stock Shares Outstanding		39,429,177
Document Fiscal Period Focus	Q2
Current Fiscal Year End Date	--12-31
Entity Central Index Key	0001801777
Amendment Flag	false
Document Fiscal Year Focus	2023
Business Contact
Entity Addresses [Line Items]
Entity Address, Address Line One	1209 Orange Street
Entity Address, City or Town	Wilmington
Entity Address, State or Province	DE
Entity Address, Postal Zip Code	19801

Condensed Balance Sheets (Unaud

Condensed Balance Sheets (Unaudited) - USD ($) $ in Thousands	Jun. 30, 2023	Dec. 31, 2022
Current assets:
Cash and cash equivalents	$ 22,457	$ 61,145
Prepaid expenses	860	2,688
Other current assets	0	186
Total current assets	23,317	64,019
Property and equipment, net	39	8,183
Operating lease right-of-use assets	1,477	33,222
Finance lease right-of-use assets	0	584
Restricted cash	0	916
Other assets	127	522
Total assets	24,960	107,446
Current liabilities:
Accounts payable	156	1,583
Accrued expenses	2,202	8,660
Lease liabilities, operating lease - current	1,458	4,639
Lease liabilities, finance lease - current	0	205
Total current liabilities	3,816	15,087
Lease liabilities, operating lease	254	31,228
Lease liabilities, finance lease	0	49
Other liabilities	244	244
Total liabilities	4,314	46,608
Commitments and contingencies
Stockholders’ equity:
Preferred stock, $0.0001 par value: 50,000,000 shares authorized; none issued and outstanding	0	0
Common stock, $0.0001 par value, 450,000,000 shares authorized; 39,429,177 and 39,181,801 shares issued and outstanding as of June 30, 2023 and December 31, 2022, respectively	4	4
Additional paid-in capital	431,862	426,804
Accumulated deficit	(411,220)	(365,970)
Total stockholders’ equity	20,646	60,838
Total liabilities and stockholders’ equity	$ 24,960	$ 107,446

Condensed Balance Sheets (Una_2

Condensed Balance Sheets (Unaudited) (Parenthetical) - $ / shares	Jun. 30, 2023	Dec. 31, 2022
Statement of Financial Position [Abstract]
Preferred stock, par value (in dollars per share)	$ 0.0001	$ 0.0001
Preferred stock, shares authorized (in shares)	50,000,000	50,000,000
Preferred stock, shares issued (in shares)	0	0
Preferred stock, shares outstanding (in shares)	0	0
Common stock, par value (in dollars per share)	$ 0.0001	$ 0.0001
Common stock, shares authorized (in shares)	450,000,000	450,000,000
Common stock, shares issued (in shares)	39,429,177	39,181,801
Common stock, shares outstanding (in shares)	39,429,177	39,181,801

Condensed Statements of Operati

Condensed Statements of Operations (Unaudited) - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2023	Jun. 30, 2022	Jun. 30, 2023	Jun. 30, 2022
Operating expenses:
Research and development	$ 2,558	$ 22,802	$ 15,546	$ 54,041
General and administrative	7,045	9,433	13,797	20,770
Restructuring, impairment, and related charges	8,129	3,787	16,872	3,787
Total operating expenses	17,732	36,022	46,215	78,598
Loss from operations	(17,732)	(36,022)	(46,215)	(78,598)
Interest income, net	419	75	998	72
Other income (expense), net	(20)	2	(33)	6
Net loss	$ (17,333)	$ (35,945)	$ (45,250)	$ (78,520)
Net loss per share, basic (in dollars per share)	$ (0.44)	$ (0.93)	$ (1.15)	$ (2.03)
Net loss per share, diluted (in dollars per share)	$ (0.44)	$ (0.93)	$ (1.15)	$ (2.03)
Weighted-average shares of common stock outstanding, basic (in shares)	39,333,046	38,748,741	39,261,122	38,695,350
Weighted-average shares of common stock outstanding, diluted (in shares)	39,333,046	38,748,741	39,261,122	38,695,350

Condensed Statements of Stockho

Condensed Statements of Stockholders' Equity (Unaudited) - USD ($) $ in Thousands	Total	Common Stock	Additional Paid-In Capital	Accumulated Deficit
Beginning balance (in shares) at Dec. 31, 2021		38,619,957
Beginning balance at Dec. 31, 2021	$ 163,587	$ 4	$ 403,228	$ (239,645)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Issuance of stock under employee stock plans (in shares)		34,206
Issuance of stock under employee stock plans	60		60
Stock-based compensation expense	6,773		6,773
Net loss	(42,575)			(42,575)
Ending balance (in shares) at Mar. 31, 2022		38,654,163
Ending balance at Mar. 31, 2022	127,845	$ 4	410,061	(282,220)
Beginning balance (in shares) at Dec. 31, 2021		38,619,957
Beginning balance at Dec. 31, 2021	163,587	$ 4	403,228	(239,645)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Net loss	(78,520)
Ending balance (in shares) at Jun. 30, 2022		38,898,695
Ending balance at Jun. 30, 2022	97,752	$ 4	415,913	(318,165)
Beginning balance (in shares) at Mar. 31, 2022		38,654,163
Beginning balance at Mar. 31, 2022	127,845	$ 4	410,061	(282,220)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Issuance of stock under employee stock plans (in shares)		244,532
Issuance of stock under employee stock plans	262		262
Stock-based compensation expense	5,590		5,590
Net loss	(35,945)			(35,945)
Ending balance (in shares) at Jun. 30, 2022		38,898,695
Ending balance at Jun. 30, 2022	$ 97,752	$ 4	415,913	(318,165)
Beginning balance (in shares) at Dec. 31, 2022	39,181,801	39,181,801
Beginning balance at Dec. 31, 2022	$ 60,838	$ 4	426,804	(365,970)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Issuance of stock under employee stock plans (in shares)		19,151
Stock-based compensation expense	3,223		3,223
Net loss	(27,917)			(27,917)
Ending balance (in shares) at Mar. 31, 2023		39,200,952
Ending balance at Mar. 31, 2023	$ 36,144	$ 4	430,027	(393,887)
Beginning balance (in shares) at Dec. 31, 2022	39,181,801	39,181,801
Beginning balance at Dec. 31, 2022	$ 60,838	$ 4	426,804	(365,970)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Net loss	$ (45,250)
Ending balance (in shares) at Jun. 30, 2023	39,429,177	39,429,177
Ending balance at Jun. 30, 2023	$ 20,646	$ 4	431,862	(411,220)
Beginning balance (in shares) at Mar. 31, 2023		39,200,952
Beginning balance at Mar. 31, 2023	36,144	$ 4	430,027	(393,887)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Issuance of stock under employee stock plans (in shares)		228,225
Issuance of stock under employee stock plans	7		7
Stock-based compensation expense	1,828		1,828
Net loss	$ (17,333)			(17,333)
Ending balance (in shares) at Jun. 30, 2023	39,429,177	39,429,177
Ending balance at Jun. 30, 2023	$ 20,646	$ 4	$ 431,862	$ (411,220)

Condensed Statements of Cash Fl

Condensed Statements of Cash Flows (Unaudited) - USD ($) $ in Thousands	6 Months Ended
	Jun. 30, 2023	Jun. 30, 2022
Operating activities
Net loss	$ (45,250)	$ (78,520)
Adjustments to reconcile net loss to net cash used in operating activities:
Stock-based compensation expense	5,051	12,363
Depreciation and amortization	829	1,791
Non-cash operating lease expense	3,216	4,510
Non-cash asset impairment charges	5,392	80
Gain on partial termination of lease	(702)	0
Loss on disposal of property and equipment	340	0
Changes in operating assets and liabilities:
Prepaid expenses	1,828	2,338
Other current assets	39	197
Other assets	36	(202)
Accounts payable	(1,432)	(56)
Accrued expenses	(6,451)	1,275
Operating lease liabilities	(3,717)	(3,299)
Other liabilities	0	3
Net cash used in operating activities	(40,821)	(59,520)
Investing activities
Purchases of property and equipment	(446)	(3,923)
Proceeds from disposal of property and equipment	1,910	0
Net cash provided by (used in) investing activities	1,464	(3,923)
Financing activities
Payments for financing and offering costs	0	(738)
Principal payments on finance lease liabilities	(254)	(132)
Proceeds from issuance of stock under employee stock plans	7	322
Net cash used in financing activities	(247)	(548)
Net decrease in cash, cash equivalents and restricted cash	(39,604)	(63,991)
Cash, cash equivalents and restricted cash, beginning of period	62,061	160,846
Cash, cash equivalents and restricted cash, end of period	22,457	96,855
Supplemental cash flow data:
Cash paid for interest on finance lease liabilities	8	15
Supplemental disclosure of non-cash investing and financing activities:
Property and equipment included in accounts payable and accrued expenses	0	244
Deferred financing and offering costs included in accounts payable and accrued expenses	$ 0	$ 29

Description of Business

Description of Business	6 Months Ended
	Jun. 30, 2023
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Description of Business	Description of Business Applied Molecular Transport Inc. (the Company or AMT) is a clinical-stage biopharmaceutical company that has a proprietary technology platform that enables the design of novel biologic product candidates in patient-friendly oral dosage forms. The Company has completed four Phase 2 clinical trials for its most advanced product candidate, AMT-101. In March 2023, the Company announced that it had commenced a process to explore strategic alternatives and is also evaluating next steps for its programs and its platform technology, including potential business development transactions. The Company continues to actively develop and prosecute its extensive intellectual property portfolio. The Company has devoted substantial resources to research and development activities and raising capital. Concurrent with the announcement, the Company’s board of directors approved a restructuring plan which is described further in the March 2023 Restructuring Plan section below. AMT was incorporated in the state of Delaware in November 2016. The Company operates under a fully-remote model and does not have a principal executive office. On August 10, 2023, the Company received a letter from the Listing Qualifications Staff (Staff) of the Nasdaq Stock Market LLC (Nasdaq) indicating that, in accordance with Nasdaq Listing Rule 5100, the Staff believes the Company is a “public shell” and that the continued listing of the Company’s securities is no longer warranted. The Company disagrees with the Staff’s determination and intends to timely appeal the Staff’s determination to Nasdaq’s Hearings Panel (Panel), which will stay any delisting action by the Staff pending the Panel’s decision (see Note 10 for additional details). March 2023 Restructuring Plan In March 2023, the Company announced the commencement of a process to explore strategic alternatives (March 2023 Restructuring Plan) and engaged MTS Health Partners, L.P. to act as the Company’s strategic financial advisor. The Company also decided to discontinue research activities and focus on completing and closing out clinical trials. The Company’s current operations include ongoing business development activities. The Company made this decision following an extensive assessment of the current business environment. To conserve cash resources pending the outcome of its strategic review, the Company restructured its business and implemented a series of cost-saving measures. These measures included implementing reductions in workforce across all functional areas impacting 63 employees representing approximately 82% of its employee base. As of the date of this report, the Company has 13 full-time employees. In connection with the March 2023 Restructuring Plan, the Company decided to operate under a fully-remote model and committed to a plan to sell all tangible fixed assets located at its leased facilities, consisting primarily of manufacturing and laboratory equipment. All tangible fixed assets were either sold or disposed of by the end of May 2023. During the quarter ended June 30, 2023, with the exception of an operating lease that is subject to a sublease in which the rental period is co-terminus with the term of the head lease and expires in August 2024, the Company exited all its operating and finance leases. As of June 30, 2023, the March 2023 Restructuring Plan was substantially complete. See Notes 4, 5 and 6 for additional details related to the financial impact of the March 2023 Restructuring Plan. Going Concern Considerations The Company has incurred net losses in each reporting period since inception, including net losses of $45.3 million and $78.5 million for the six months ended June 30, 2023 and 2022, respectively, and the Company’s accumulated deficit at June 30, 2023 was $411.2 million. The Company’s current operating plan, which is subject to change based on the ongoing strategic review, indicates it will continue to incur losses from operations and generate negative cash flows from operating activities, given the Company does not generate any revenue from product sales or otherwise. As a result of the restructuring actions described above, including discontinuing research activities, exiting substantially all of its operating and finance leases, and significantly reducing its workforce, management believes the Company’s existing cash and cash equivalents of $22.5 million as of June 30, 2023 are adequate to meet its cash needs for at least 12 months from the issuance date of these condensed financial statements. While the Company is exploring strategic alternatives, there can be no assurance that this process will result in the Company pursuing a transaction or that any transaction, if pursued, will be completed on attractive terms, or at all. Similarly, there can be no assurance that sources of capital will be available to the Company in the necessary time frame, in the amounts that the Company requires, on terms that are acceptable to the Company, or at all. If the Company is unable to consummate a strategic transaction or raise the necessary funds when needed or reduce spending on currently planned activities, the Company may be required to cease operations, which could materially harm its business, financial position and results of operations. In January 2022, the Company entered into a Sales Agreement with SVB Securities LLC and JMP Securities LLC, as the Company’s sales agents (Agents), pursuant to which the Company may offer and sell from time to time through the Agents up to $150.0 million in shares of the Company’s common stock through an “at-the-market” program (ATM Facility). The shares will be offered and sold pursuant to the Company’s shelf registration statement on Form S-3 (File No. 333-263501) and the final prospectus supplement, which was filed on March 11, 2022. For so long as the Company’s non-affiliate public float does not exceed $75 million, the amount of securities that the Company may sell pursuant to registration statements on Form S-3 will be limited to the equivalent of one-third of its public float, which will limit its ability to raise capital. As of June 30, 2023, the Company has not yet sold any shares under the ATM facility and does not currently intend to do so. Current Economic Environment The extent of the ongoing impact of macroeconomic events on the Company’s business and on global economic activity is uncertain and the related financial impact cannot be reasonably estimated with any certainty at this time, although the impacts are expected to continue and may significantly affect its business. The Company expects that the impacts on its business will continue through this period of economic uncertainty as inflation, instability in the banking and financial services sector, a tightening of the credit markets, and other factors continue to develop or emerge. Accordingly, management is carefully evaluating the Company’s liquidity position and continuing to review its near-term operating expenses as the uncertainty related to these factors continues to unfold.

Summary of Significant Accounti

Summary of Significant Accounting Policies	6 Months Ended
	Jun. 30, 2023
Accounting Policies [Abstract]
Summary of Significant Accounting Policies	Summary of Significant Accounting Policies Financial Statement Preparation The accompanying unaudited condensed financial statements have been prepared in accordance with accounting principles generally accepted in the United States (GAAP) and applicable rules and regulations of the SEC for interim reporting. As permitted under those rules and regulations, certain footnotes or other financial information normally included in financial statements prepared in accordance with GAAP have been condensed or omitted. Similarly, the balance sheet as of December 31, 2022 was derived from the Company’s audited financial statements but does not include all disclosures required by GAAP. The condensed financial statements have been prepared on the same basis as the annual financial statements and, in the opinion of management, reflect all adjustments, which include only normal, recurring adjustments that are necessary for a fair statement of the results for interim periods. Results of operations for interim periods may not be representative of results to be expected for a full year. The accompanying condensed financial statements should be read in conjunction with the audited financial statements and the related notes thereto included in the Company’s Annual Report on Form 10-K for the year ended December 31, 2022. Certain reclassifications have been made to the prior period amounts to conform to the current year presentation. In particular, in the condensed statements of operations for the three and six months ended June 30, 2022, the Company reclassified $3.1 million and $0.7 million from “Research and development” and “General and administrative,” respectively, to a new line item “Restructuring, impairment, and related charges,” primarily related to severance and contract termination costs. These reclassifications did not affect our financial position, net loss, or cash flows as of and for the periods presented. Use of Estimates The preparation of financial statements in conformity with GAAP requires management to make estimates and assumptions that affect the amounts reported in the financial statements and accompanying notes. The Company bases its estimates on historical experience and market-specific or other relevant assumptions that it believes are reasonable under the circumstances. Assets and liabilities reported in the Company’s condensed balance sheets and expenses and income reported are affected by estimates and assumptions, which are used for, but are not limited to, recording research and development expenses and related accruals, valuation of long-lived assets, including right-of-use assets and leasehold improvements, restructuring and other charges, and determining the fair value of stock options for stock-based compensation expense. The Company assessed certain accounting matters that generally require consideration of forecasted financial information in context with the information reasonably available to the Company. Actual results could differ from such estimates or assumptions. Concentration of Credit Risk Financial instruments that potentially subject the Company to significant concentrations of credit risk consist primarily of cash and cash equivalents. The Company maintains bank deposits in federally insured financial institutions and, from time to time, these deposits may exceed federally insured limits. The Company is exposed to credit risk in the event of default by the financial institutions holding its cash and cash equivalents to the extent recorded in the condensed balance sheets. The Company’s cash equivalents consist of money market funds that invests all of its assets in direct obligations of the U.S. Treasury. Although the fund invests in U.S. government obligations, an investment in such funds is neither insured nor guaranteed by the U.S. government. The Company has not experienced any losses on its deposits of cash or holdings of money market funds. Significant Accounting Policies The significant accounting policies set forth in Note 2 to the financial statements in the Company’s 2022 Form 10-K appropriately represent, in all material respects, the current status of our accounting policies, except as described below. Restructuring Charges Restructuring charges are recorded in accordance with Accounting Standards Codification (ASC) 712-10, “Nonretirement Postemployment Benefits,” or “ASC 712-10,” and/or ASC 420-10, “Exit or Disposal Cost Obligations,” or “ASC 420-10,” as appropriate. Certain termination costs and obligations of contracts that are not leases are accounted for in accordance with ASC 420-10. The Company records severance costs provided under an ongoing benefit arrangement once they are both probable and estimable in accordance with the provisions of ASC 712-10. The Company accounts for one-time termination benefits and contract terminations in accordance with ASC 420-10, which addresses financial accounting and reporting for costs associated with restructuring activities. Under ASC 420-10, the Company establishes a liability for a cost associated with an exit or disposal activity, including severance and other contract termination costs, when the liability is incurred, rather than at the date that the Company commits to an exit plan. The Company reassesses the expected cost to complete the exit or disposal activities at the end of each reporting period and adjusts its remaining estimated liabilities, if necessary. Impairment of Long-Lived Assets The Company assesses long-lived assets for impairment whenever events or changes in circumstances indicate that the carrying amount of an asset or asset group may not be recoverable. Such events include a significant change in the Company’s strategic business objectives and utilization of the assets. As part of the March 2023 Restructuring Plan, the Company commenced restructuring activities that included the decision to operate as a fully-remote company and discontinue research activities while focusing on completing and closing out clinical trials. In anticipation of exiting its leased facilities, the Company committed to a plan to sell all tangible fixed assets located at its leased facilities, consisting primarily of manufacturing and laboratory equipment. In connection with the classification of such assets as held for sale, the carrying value of the tangible fixed assets to be sold was reduced to their estimated fair value, which was determined based on the estimated selling price less costs to sell. In May 2023, the Company modified various operating leases to shorten the accounting lease term. Upon vacating the leased premises in the second quarter of 2023, the Company wrote-off the remaining balances related to right-of-use assets and leasehold improvements. Refer to Notes 4, 5 and 6 for additional details regarding restructuring and impairment charges related to the March 2023 Restructuring Plan. Cash, Cash Equivalents and Restricted Cash Cash and cash equivalents are held in accounts at financial institutions. As of June 30, 2023, the Company’s cash in deposit accounts were insured by the Federal Deposit Insurance Corporation (FDIC) as the balances were within the FDIC insurance limit of up to $250,000 per depositor at each financial institution. The Company considers all highly liquid investments purchased with original maturities of 90 days or less from the purchase date to be cash equivalents. Cash equivalents consist of amounts invested in money market funds exclusively composed of U.S. government obligations. Restricted cash consisted of cash balances held by financial institutions as collateral for letters of credit maintained by the Company for the benefit of lessors related to its leased properties as of June 30, 2022. The following table provides a reconciliation of cash, cash equivalents and restricted cash reported within the condensed statements of cash flows (in thousands): June 30, June 30, Cash and cash equivalents $ 22,457 $ 95,830 Restricted cash — 1,025 Total cash, cash equivalents and restricted cash $ 22,457 $ 96,855 Recently Adopted Accounting Pronouncements Accounting pronouncements that became effective during the six months ended June 30, 2023 did not have a material impact on the Company’s financial condition, results of operations or cash flows. Recently Issued Accounting Pronouncements There were no new accounting pronouncements issued as of June 30, 2023 that are expected to have a material impact on the Company’s financial condition, results of operations or cash flows.

Fair Value Measurements

Fair Value Measurements	6 Months Ended
	Jun. 30, 2023
Fair Value Disclosures [Abstract]
Fair Value Measurements	Fair Value Measurements Fair value is defined as the exchange price that would be received for an asset or paid to transfer a liability, or an exit price, in the principal or most advantageous market for that asset or liability in an orderly transaction between market participants on the measurement date. A three-level valuation hierarchy has been established under GAAP for disclosure of fair value measurements. The valuation hierarchy is based on the transparency of inputs to the valuation of an asset or liability as of the measurement date. The three levels are defined as follows: • Level 1—Quoted prices in active markets for identical assets and liabilities; • Level 2—Inputs other than Level 1 that are observable, either directly or indirectly, such as quoted prices for similar assets or liabilities, quoted prices in markets that are not active, or other inputs that are observable or can be corroborated by observable market data for substantially the full term of the assets or liabilities; and • Level 3—Unobservable inputs that are supported by little or no market activity and that are significant to the fair value of the assets or liabilities. Assets Measured at Fair Value on a Recurring Basis As of June 30, 2023 and December 31, 2022, money market funds were the only financial instrument measured and recorded at fair value on a recurring basis on the Company’s condensed balance sheets. Money market funds were recorded within cash and cash equivalents. The following tables present money market funds at their level within the fair value hierarchy for the periods indicated (in thousands): June 30, 2023 Fair Value Hierarchy Level Amortized Cost Gross Unrealized Gains Gross Unrealized Losses Fair Value Cash equivalents: Money market funds invested in U.S. government obligations Level 1 $ 22,217 $ — $ — $ 22,217 Total $ 22,217 $ — $ — $ 22,217 December 31, 2022 Fair Value Hierarchy Level Amortized Cost Gross Unrealized Gains Gross Unrealized Losses Fair Value Cash equivalents: Money market funds invested in U.S. government obligations Level 1 $ 40,729 $ — $ — $ 40,729 Total $ 40,729 $ — $ — $ 40,729 Financial Instruments Not Carried at Fair Value The Company’s financial instruments, including cash, restricted cash, other current assets, accounts payable and accrued expenses are carried at cost which approximates their fair value because of the short-term nature of these financial instruments.

Balance Sheet Components

Balance Sheet Components	6 Months Ended
	Jun. 30, 2023
Balance Sheet Related Disclosures [Abstract]
Balance Sheet Components	Balance Sheet Components Prepaid Expenses Prepaid clinical expenses were $0.4 million and $1.2 million as of June 30, 2023 and December 31, 2022, respectively. Other prepaid expenses as of June 30, 2023 and December 31, 2022 included prepaid amounts for insurance and other prepaid services. Property and Equipment, Net Property and equipment, net, consisted of the following (in thousands): June 30, December 31, Laboratory and manufacturing equipment $ — $ 11,421 Leasehold improvements 221 5,246 Computer and office equipment — 491 Construction in progress — 72 Total property and equipment, gross 221 17,230 Accumulated depreciation (182) (9,047) Total property and equipment, net $ 39 $ 8,183 Property and equipment, net decreased significantly for the six months ended June 30, 2023 as a result of the March 2023 Restructuring Plan. As further disclosed in Notes 5 and 6, as part of the March 2023 Restructuring Plan, the Company decided to operate under a fully-remote model and committed to a plan to sell all tangible fixed assets located at its leased facilities, consisting primarily of manufacturing and laboratory equipment. In addition, the Company modified its operating leases to shorten their lease term. For the six months ended June 30, 2023, the Company recognized non-cash impairment charges totaling $5.4 million as a result of classifying all tangible fixed assets as held for sale and to write-off leasehold improvements upon vacating leased premises. All tangible fixed assets were either sold or disposed of during the quarter ended June 30, 2023. Depreciation expense was $0.1 million and $0.8 million for the three months ended June 30, 2023 and 2022, respectively, and $0.7 million and $1.7 million for the six months ended June 30, 2023 and 2022, respectively. Accrued Expenses Accrued expenses consisted of the following (in thousands): June 30, December 31, Professional services $ 1,300 $ 728 Compensation expenses 549 3,985 Research and development expenses — 3,508 Property and equipment — 7 Other 353 432 Total accrued expenses $ 2,202 $ 8,660

Restructuring, Impairment, and

Restructuring, Impairment, and Related Charges	6 Months Ended
	Jun. 30, 2023
Restructuring and Related Activities [Abstract]
Restructuring, Impairment, and Related Charges	Restructuring, Impairment, and Related Charges A description of the Company’s restructuring initiatives and their related costs is provided below. March 2023 Restructuring Plan Employee Termination Benefits As discussed in Note 1, in March 2023, the Company implemented reductions in workforce across all functional areas impacting 63 employees representing approximately 82% of its employee base. Impacted employees were eligible to receive severance benefits and Company-funded COBRA premiums, contingent upon an impacted employee’s execution (and non-revocation) of a customary separation agreement, which includes a general release of claims against the Company. For the six months ended June 30, 2023, the Company recognized $5.6 million of employee termination benefits provided under an ongoing benefit arrangement, which were fully paid as of June 30, 2023. Asset Impairments As part of the March 2023 Restructuring Plan, the Company decided to operate under a fully-remote model and committed to a plan to sell all tangible fixed assets located at its leased facilities, consisting primarily of manufacturing and laboratory equipment. In addition, the Company modified its operating leases to shorten their lease term. For the six months ended June 30, 2023, the Company recognized non-cash impairment charges totaling $5.4 million as a result of classifying all tangible fixed assets as held for sale and to write-off leasehold improvements upon vacating leased premises. All tangible fixed assets were either sold or disposed of during the quarter ended June 30, 2023. During the quarter ended June 30, 2023, with the exception of an operating lease that is subject to a sublease in which the rental period is co-terminus with the term of the head lease and expires in August 2024, the Company exited all its operating and finance leases (see Note 6) and recorded impairment charges to write off right-of-use assets and related leasehold improvements upon vacating the leased premises. Other Related Costs The Company incurred other related costs of $0.6 million for the six months ended June 30, 2023 primarily consisting of costs to terminate contracts before the end of their term, costs for professional services incurred in connection with restructuring measures of $1.0 million and a $0.3 million loss on disposal of fixed assets, partially offset by a $0.7 million gain on partial termination of lease. May 2022 Restructuring Plan In May 2022, the Company implemented a restructuring plan (May 2022 Restructuring Plan) to preserve capital and focus its resources on advancing its then lead product candidate through key development milestones. The May 2022 Restructuring Plan resulted in a reduction of the Company’s workforce by approximately 40%, or 52 employees. For the three and six months ended June 30, 2022, the Company incurred total charges of approximately $3.8 million under the May 2022 Restructuring Plan, primarily consisting of $3.3 million related to severance payments and other employee-related separation costs, $0.8 million related to contract termination and facility exit costs and $0.1 million in write-offs of property and equipment, partially offset by a $0.4 million reduction in stock-based compensation expense as a result of applying modification accounting for accelerated vesting of RSUs related to impacted employees. The following table details “Restructuring, impairment, and related charges” for each of the periods presented (in thousands): Three Months Ended Six Months Ended 2023 2022 2023 2022 Employee termination benefits $ (41) $ 3,339 $ 5,585 $ 3,339 Stock-based compensation — (419) — (419) Asset impairments 7,748 80 10,642 80 Other related costs 422 787 645 787 Total restructuring, impairments, and related charges $ 8,129 $ 3,787 $ 16,872 $ 3,787 The following table summarizes the charges and spending relating to restructuring program activities for the six months ended June 30, 2023: Employee Termination Benefits Asset Impairments Other Related Costs Total Liability balance at December 31, 2022 $ — $ — $ 420 $ 420 Expense 5,585 10,642 645 16,872 Payments (5,585) (5,250) (1) (1,282) (12,117) Non-cash activity — (5,392) 362 (5,030) Liability balance at June 30, 2023 (2) $ — $ — $ 145 $ 145 (1) Represents cash payments for early termination fees associated with exiting operating leases, which were recorded as increases to right-of-use assets. Upon vacating the leased premises, any remaining balances related to right-of-use assets were written off. (2) The remaining cash outlays related to restructuring programs are expected to be substantially completed by the end of the third quarter of 2023.

Leases

Leases	6 Months Ended
	Jun. 30, 2023
Leases [Abstract]
Leases	Leases Operating Leases In February 2021, the Company entered into an operating lease for its headquarters comprising 84,321 of rentable square feet of office, laboratory and manufacturing space in South San Francisco, California (HQ Lease), which was originally scheduled to expire in October 2029. As part of the Company’s March 2023 Restructuring Plan, the Company decided to operate under a fully-remote model. In May 2023, the Company entered into a modification of the HQ Lease (Lease Modification), which shortened the accounting lease term to May 2023. In addition, the Company assigned an active sublease for the third floor of the leased building under the HQ Lease to the landlord effective as of the execution date. As the Company’s right of use for the third floor of the leased building ceased contemporaneously with the modification, the Company determined the percentage reduction in leased space and applied the resulting percentage to remeasure the remaining right-of-use asset and lease liability reducing them by $10.0 million and $10.7 million, respectively, which resulted in a gain on partial lease termination of $0.7 million. The gain on partial lease termination was included within the “Restructuring, impairment, and related charges” line in the statement of operations for the three and six months ended June 30, 2023. Pursuant to the Lease Modification, the Company incurred an early termination fee of $5.3 million. The early termination fee included the forfeiture of a security deposit of $0.9 million in the form of a letter of credit. Under Accounting Standards Codification 842, Leases , when a lease is terminated early but the tenant continues to control the space under a modified lease agreement for a short period of time, early termination fees associated with exiting operating leases are recorded as prepaid rent for the remaining lease term resulting in an increase to the right-of-use asset. Upon vacating the leased premises in May 2023, the Company wrote-off the remaining balances related to right-of-use assets and leasehold improvements. Refer to Note 5 for additional details. Also in May 2023, the Company entered into a modification of an operating lease for approximately 20,000 rentable square feet of warehouse space in South San Francisco, California, which shortened the accounting lease term to June 2023. The lease was originally scheduled to expire in July 2029. The Company incurred an early termination fee of $0.8 million. The early termination fee included the forfeiture of a security deposit of $0.3 million, which was recorded as prepaid rent for the remaining lease term resulting in an increase to the right-of-use asset. Upon vacating the leased premises in June 2023, the Company wrote-off the remaining balances related to right-of-use assets and leasehold improvements. Refer to Note 5 for additional details. As of June 30, 2023, the Company has one remaining operating lease for approximately 18,748 rentable square feet of office and laboratory space in South San Francisco, California, which served as the Company’s headquarters through February 2021. The lease expires in August 2024. In November 2021, the Company subleased this facility in which the rental period was co-terminus with the term of the head lease. The subtenant was not provided any renewal or extension options. Finance Leases During the quarter ended June 30, 2023, the Company early terminated all its finance lease agreements, which were related to laboratory and manufacturing equipment. The terms of the Company’s finance leases generally ranged from three The following table summarizes total lease expense for the three and six months ended June 30, 2023 and 2022 (in thousands): Condensed Statements of Operations Classification Three Months Ended Six Months Ended 2023 2022 2023 2022 Operating lease expense Operating expenses $ 1,251 $ 2,240 $ 3,216 $ 4,509 Finance lease expense: Amortization of ROU assets Operating expenses 21 56 82 106 Interest on lease liabilities Interest income, net 1 8 8 15 Variable lease expense Operating expenses 322 571 640 1,132 Short-term lease expense Operating expenses — 5 5 67 Sublease income Operating expenses (523) (495) (1,333) (900) Total lease expense $ 1,072 $ 2,385 $ 2,618 $ 4,929 The following table summarizes supplemental cash flow information for the six months ended June 30, 2023 and 2022 (in thousands): Six Months Ended June 30, 2023 2022 Cash paid for amounts included in the measurement of liabilities: Operating cash flows from operating leases $ 3,717 $ 3,299 Operating cash flows from finance leases 8 15 Financing cash flows from finance leases 254 132 Right-of-use asset obtained in exchange for new operating lease liability — 563 Right-of-use asset obtained in exchange for new finance lease liability 114 148 The following table summarizes maturities of lease liabilities and sublease income as of June 30, 2023 (in thousands): Operating Leases Sublease Income Payments Net Lease Income Payments 2023 (remaining six months) $ 737 $ (766) $ (29) 2024 1,000 (1,044) (44) Total lease payments (undiscounted) 1,737 $ (1,810) $ (73) Less interest or imputed interest (25) Total present value of lease liabilities 1,712 Less: Lease liabilities, current (1,458) Lease liabilities, non-current $ 254
Leases	Leases Operating Leases In February 2021, the Company entered into an operating lease for its headquarters comprising 84,321 of rentable square feet of office, laboratory and manufacturing space in South San Francisco, California (HQ Lease), which was originally scheduled to expire in October 2029. As part of the Company’s March 2023 Restructuring Plan, the Company decided to operate under a fully-remote model. In May 2023, the Company entered into a modification of the HQ Lease (Lease Modification), which shortened the accounting lease term to May 2023. In addition, the Company assigned an active sublease for the third floor of the leased building under the HQ Lease to the landlord effective as of the execution date. As the Company’s right of use for the third floor of the leased building ceased contemporaneously with the modification, the Company determined the percentage reduction in leased space and applied the resulting percentage to remeasure the remaining right-of-use asset and lease liability reducing them by $10.0 million and $10.7 million, respectively, which resulted in a gain on partial lease termination of $0.7 million. The gain on partial lease termination was included within the “Restructuring, impairment, and related charges” line in the statement of operations for the three and six months ended June 30, 2023. Pursuant to the Lease Modification, the Company incurred an early termination fee of $5.3 million. The early termination fee included the forfeiture of a security deposit of $0.9 million in the form of a letter of credit. Under Accounting Standards Codification 842, Leases , when a lease is terminated early but the tenant continues to control the space under a modified lease agreement for a short period of time, early termination fees associated with exiting operating leases are recorded as prepaid rent for the remaining lease term resulting in an increase to the right-of-use asset. Upon vacating the leased premises in May 2023, the Company wrote-off the remaining balances related to right-of-use assets and leasehold improvements. Refer to Note 5 for additional details. Also in May 2023, the Company entered into a modification of an operating lease for approximately 20,000 rentable square feet of warehouse space in South San Francisco, California, which shortened the accounting lease term to June 2023. The lease was originally scheduled to expire in July 2029. The Company incurred an early termination fee of $0.8 million. The early termination fee included the forfeiture of a security deposit of $0.3 million, which was recorded as prepaid rent for the remaining lease term resulting in an increase to the right-of-use asset. Upon vacating the leased premises in June 2023, the Company wrote-off the remaining balances related to right-of-use assets and leasehold improvements. Refer to Note 5 for additional details. As of June 30, 2023, the Company has one remaining operating lease for approximately 18,748 rentable square feet of office and laboratory space in South San Francisco, California, which served as the Company’s headquarters through February 2021. The lease expires in August 2024. In November 2021, the Company subleased this facility in which the rental period was co-terminus with the term of the head lease. The subtenant was not provided any renewal or extension options. Finance Leases During the quarter ended June 30, 2023, the Company early terminated all its finance lease agreements, which were related to laboratory and manufacturing equipment. The terms of the Company’s finance leases generally ranged from three The following table summarizes total lease expense for the three and six months ended June 30, 2023 and 2022 (in thousands): Condensed Statements of Operations Classification Three Months Ended Six Months Ended 2023 2022 2023 2022 Operating lease expense Operating expenses $ 1,251 $ 2,240 $ 3,216 $ 4,509 Finance lease expense: Amortization of ROU assets Operating expenses 21 56 82 106 Interest on lease liabilities Interest income, net 1 8 8 15 Variable lease expense Operating expenses 322 571 640 1,132 Short-term lease expense Operating expenses — 5 5 67 Sublease income Operating expenses (523) (495) (1,333) (900) Total lease expense $ 1,072 $ 2,385 $ 2,618 $ 4,929 The following table summarizes supplemental cash flow information for the six months ended June 30, 2023 and 2022 (in thousands): Six Months Ended June 30, 2023 2022 Cash paid for amounts included in the measurement of liabilities: Operating cash flows from operating leases $ 3,717 $ 3,299 Operating cash flows from finance leases 8 15 Financing cash flows from finance leases 254 132 Right-of-use asset obtained in exchange for new operating lease liability — 563 Right-of-use asset obtained in exchange for new finance lease liability 114 148 The following table summarizes maturities of lease liabilities and sublease income as of June 30, 2023 (in thousands): Operating Leases Sublease Income Payments Net Lease Income Payments 2023 (remaining six months) $ 737 $ (766) $ (29) 2024 1,000 (1,044) (44) Total lease payments (undiscounted) 1,737 $ (1,810) $ (73) Less interest or imputed interest (25) Total present value of lease liabilities 1,712 Less: Lease liabilities, current (1,458) Lease liabilities, non-current $ 254

Commitments and Contingencies

Commitments and Contingencies	6 Months Ended
	Jun. 30, 2023
Commitments and Contingencies Disclosure [Abstract]
Commitments and Contingencies	Commitments and Contingencies Commitments In February 2023, the Company entered into an agreement with MTS Health Partners, L.P. to act as the Company’s strategic financial advisor in connection with a potential strategic transaction, including, but not limited to, an acquisition, merger, business combination or other transaction. Upon the consummation of any such transaction, the Company has agreed to pay the advisor a success fee of 3% of the Total Consideration (as defined in the agreement) received by the Company, with a minimum fee of $2.0 million. If there is a second transaction, the Company has agreed to pay the advisor a success fee of 3.0% of the Total Consideration (as defined in the agreement) received by the Company, with a minimum fee of $1.5 million. Any success fees payable will be recognized as an expense in the period it is incurred. Legal Proceedings From time to time, the Company may become involved in legal proceedings arising in the ordinary course of business. The Company was not subject to any material legal proceedings as of June 30, 2023 and December 31, 2022, and no material legal proceedings are currently pending or threatened. Indemnification In the ordinary course of business, the Company enters into agreements that may include indemnification provisions. As permitted under Delaware law and in accordance with its bylaws, the Company indemnifies its officers and directors for certain events or occurrences while the officer or director is or was serving in such capacity. The Company is also party to indemnification agreements with its officers and directors. In some cases, the indemnification will continue after the termination of the agreement. The maximum potential amount of future payments that the Company could be required to make under these provisions is not determinable. The Company also maintains director and officer insurance, which may cover certain liabilities arising from the Company’s obligation to indemnify directors and officers. The Company has never incurred costs to defend lawsuits or settle claims related to these indemnification provisions and is not currently aware of any indemnification claims.

Common Stock and Stock-Based Co

Common Stock and Stock-Based Compensation	6 Months Ended
	Jun. 30, 2023
Share-Based Payment Arrangement [Abstract]
Common Stock and Stock-Based Compensation	Common Stock and Stock-Based Compensation Common Stock As of June 30, 2023 and December 31, 2022, the Company was authorized to issue 450,000,000 shares of $0.0001 par value common stock. Common stockholders are entitled to dividends if and when declared by the Board of Directors. The holder of each share of common stock is entitled to one vote. The Company has never declared or paid dividends on its common stock. Common stock reserved for future issuance, on an as converted basis, consisted of the following: June 30, December 31, Stock options outstanding 3,272,024 5,369,808 RSUs and PSUs outstanding 3,474,780 531,366 Shares available for future grants under equity incentive plans 5,551,006 4,654,922 Shares available for issuance under ESPP 1,234,610 872,792 Total 13,532,420 11,428,888 On January 1, 2023, the shares available for grant under the Company’s 2020 Equity Incentive Plan and the 2020 ESPP were automatically increased by 1,959,090 shares and 391,818 shares, respectively, pursuant to the annual evergreen increase provisions under each respective plan. Stock-based Compensation The Company has awards outstanding under various stock-based compensation plans as described in the financial statements and related notes included in the Company’s Annual Report on Form 10-K for the year ended December 31, 2022. The Company utilizes stock options, restricted stock units (RSUs) and performance stock units (PSUs) for equity compensation. Stock-based compensation expense is measured at fair value on the date of grant and recognized ratably over the requisite service period. The following table summarizes the components of stock-based compensation expense recognized in the Company’s condensed statements of operations during the three and six months ended June 30, 2023 and 2022 (in thousands): Three Months Ended Six Months Ended 2023 2022 2023 2022 Research and development $ 13 $ 2,859 $ 972 $ 6,295 General and administrative 1,815 3,150 4,079 6,487 Restructuring, impairment, and related charges — (419) — (419) Total stock-based compensation expense $ 1,828 $ 5,590 $ 5,051 $ 12,363 Stock Options The following summarizes stock option activity (in thousands, except share, per share, and year amounts): Total Options Outstanding Weighted- Weighted- Aggregate Outstanding as of December 31, 2022 5,369,808 $ 17.28 7.6 $ 11 Granted 768,000 0.39 Exercised — — Canceled (2,865,784) 17.44 Outstanding as of June 30, 2023 3,272,024 $ 13.18 7.2 $ — Exercisable as of June 30, 2023 1,970,466 $ 13.25 6.2 $ — As of June 30, 2023, the total unrecognized stock-based compensation expense related to stock options was $11.0 million, which is expected to be recognized over a weighted-average period of approximately 2.0 years. Restricted Stock Units and Performance Stock Units The following summarizes RSU and PSU activity: RSUs PSUs Number of Shares Weighted- Number of Shares Weighted- Outstanding as of December 31, 2022 531,366 $ 10.12 — $ — Granted — — 3,461,640 0.30 Vested (67,664) 10.64 (149,712) 0.31 Canceled (300,850) 11.04 — — Outstanding as of June 30, 2023 162,852 $ 8.21 3,311,928 $ 0.30 In April 2023, the Company granted 2,575,529 PSUs, pursuant to the terms and conditions of the Company’s 2020 Equity Incentive Plan, to employees that contain performance conditions associated with a strategic transaction, if such a transaction occurs. The awards also vest in full if an employee is involuntarily terminated. Also in April 2023, the Company entered into a Consulting Agreement with Tahir Mahmood, a current director of the Company and the Company’s co-founder and former CEO. The Consulting Agreement has a six-month term and will expire in October 2023. Under the terms of the Consulting Agreement, Dr. Mahmood will provide consulting services relating to potential strategic transactions. As consideration for the Consulting Agreement, Dr. Mahmood was granted 886,111 PSUs, pursuant to the terms and conditions of the Company’s 2020 Equity Incentive Plan, that contain performance conditions associated with a strategic transaction, if such a transaction occurs. The fair value of each PSU is determined on the date of grant based on the Company’s stock price. During the six months ended June 30, 2023, 149,712 PSUs vested in full upon the holders’ involuntary termination. As of June 30, 2023, the Company determined the performance conditions of outstanding PSUs were not probable of achievement until the event actually occurs and, to date, no compensation expense has been recognized. As of June 30, 2023, the total unrecognized stock-based compensation expense related to unvested RSUs was $1.2 million, which is expected to be recognized over a weighted-average period of approximately 2.2 years. The unrecognized compensation related to unvested PSUs was $1.0 million.

Net Loss Per Share

Net Loss Per Share	6 Months Ended
	Jun. 30, 2023
Earnings Per Share [Abstract]
Net Loss Per Share	Net Loss Per Share Basic net loss per common share is computed by dividing net loss by the weighted-average number of shares of common stock outstanding during the period. Diluted net loss per share of common stock is computed by giving effect to all potential dilutive shares of common stock, including options, RSUs and PSUs. Basic and diluted net loss per share were the same for all periods presented as the impact of all potentially dilutive securities outstanding was anti-dilutive. The following table sets forth the computation of the basic and diluted net loss per share (in thousands except share and per share data): Three Months Ended Six Months Ended 2023 2022 2023 2022 Numerator: Net loss $ (17,333) $ (35,945) $ (45,250) $ (78,520) Denominator: Weighted-average shares of common stock outstanding used in the calculation of basic and diluted net loss per share 39,333,046 38,748,741 39,261,122 38,695,350 Net loss per share, basic and diluted $ (0.44) $ (0.93) $ (1.15) $ (2.03) The Company’s basic net loss per share was the same as its diluted net loss per share for all the periods presented as the inclusion of all common stock equivalents outstanding would have been anti-dilutive. Potentially dilutive securities that were not included in the diluted per share calculations because they would be anti-dilutive were as follows: June 30, 2023 2022 Stock options outstanding 3,272,024 6,260,697 RSUs and PSUs outstanding 3,474,780 774,483

Subsequent Events

Subsequent Events	6 Months Ended
	Jun. 30, 2023
Subsequent Events [Abstract]
Subsequent Events	Subsequent Events On August 10, 2023, the Company received a letter from the Staff indicating that, in accordance with Nasdaq Listing Rule 5100, the Staff believes the Company is a “public shell” and that the continued listing of the Company’s securities is no longer warranted. The Company disagrees with the Staff’s determination and intends to timely appeal the Staff’s determination to the Panel, which will stay any delisting action by the Staff pending the Panel’s decision. According to the letter, the Staff believes that the Company “no longer has an operating business” and consequently has decided to use its discretion “to apply more stringent criteria” to the Company’s listing. The Staff’s letter also indicates that the Company was not in compliance with Nasdaq Listing Rule 5450(a)(1), which requires the Company’s common stock to maintain a share price of at least $1.00 per share (the Bid Price Rule) for continued listing on the Nasdaq Global Select Market. This serves as an additional and separate basis for delisting. The Company disagrees with the Staff’s determination about the “public shell” given that it continues to conduct itself with significant operations that are not nominal including, among other things, through its employees, consultants and outsourced clinical and regulatory activities, the maintenance of its clinical assets and platform technology, and associated intellectual property and patent portfolio, and its business development activities.

Summary of Significant Accoun_2

Summary of Significant Accounting Policies (Policies)	6 Months Ended
	Jun. 30, 2023
Accounting Policies [Abstract]
Financial Statement Preparation	Financial Statement Preparation The accompanying unaudited condensed financial statements have been prepared in accordance with accounting principles generally accepted in the United States (GAAP) and applicable rules and regulations of the SEC for interim reporting. As permitted under those rules and regulations, certain footnotes or other financial information normally included in financial statements prepared in accordance with GAAP have been condensed or omitted. Similarly, the balance sheet as of December 31, 2022 was derived from the Company’s audited financial statements but does not include all disclosures required by GAAP. The condensed financial statements have been prepared on the same basis as the annual financial statements and, in the opinion of management, reflect all adjustments, which include only normal, recurring adjustments that are necessary for a fair statement of the results for interim periods. Results of operations for interim periods may not be representative of results to be expected for a full year. The accompanying condensed financial statements should be read in conjunction with the audited financial statements and the related notes thereto included in the Company’s Annual Report on Form 10-K for the year ended December 31, 2022. Certain reclassifications have been made to the prior period amounts to conform to the current year presentation. In particular, in the condensed statements of operations for the three and six months ended June 30, 2022, the Company reclassified $3.1 million and $0.7 million from “Research and development” and “General and administrative,” respectively, to a new line item “Restructuring, impairment, and related charges,” primarily related to severance and contract termination costs. These reclassifications did not affect our financial position, net loss, or cash flows as of and for the periods presented.
Use of Estimates	Use of Estimates The preparation of financial statements in conformity with GAAP requires management to make estimates and assumptions that affect the amounts reported in the financial statements and accompanying notes. The Company bases its estimates on historical experience and market-specific or other relevant assumptions that it believes are reasonable under the circumstances. Assets and liabilities reported in the Company’s condensed balance sheets and expenses and income reported are affected by estimates and assumptions, which are used for, but are not limited to, recording research and development expenses and related accruals, valuation of long-lived assets, including right-of-use assets and leasehold improvements, restructuring and other charges, and determining the fair value of stock options for stock-based compensation expense. The Company assessed certain accounting matters that generally require consideration of forecasted financial information in context with the information reasonably available to the Company. Actual results could differ from such estimates or assumptions.
Concentration of Credit Risk	Concentration of Credit Risk Financial instruments that potentially subject the Company to significant concentrations of credit risk consist primarily of cash and cash equivalents. The Company maintains bank deposits in federally insured financial institutions and, from time to time, these deposits may exceed federally insured limits. The Company is exposed to credit risk in the event of default by the financial institutions holding its cash and cash equivalents to the extent recorded in the condensed balance sheets. The Company’s cash equivalents consist of money market funds that invests all of its assets in direct obligations of the U.S. Treasury. Although the fund invests in U.S. government obligations, an investment in such funds is neither insured nor guaranteed by the U.S. government. The Company has not experienced any losses on its deposits of cash or holdings of money market funds.
Restructuring Charges	Restructuring Charges Restructuring charges are recorded in accordance with Accounting Standards Codification (ASC) 712-10, “Nonretirement Postemployment Benefits,” or “ASC 712-10,” and/or ASC 420-10, “Exit or Disposal Cost Obligations,” or “ASC 420-10,” as appropriate. Certain termination costs and obligations of contracts that are not leases are accounted for in accordance with ASC 420-10. The Company records severance costs provided under an ongoing benefit arrangement once they are both probable and estimable in accordance with the provisions of ASC 712-10. The Company accounts for one-time termination benefits and contract terminations in accordance with ASC 420-10, which addresses financial accounting and reporting for costs associated with restructuring activities. Under ASC 420-10, the Company establishes a liability for a cost associated with an exit or disposal activity, including severance and other contract termination costs, when the liability is incurred, rather than at the date that the Company commits to an exit plan. The Company reassesses the expected cost to complete the exit or disposal activities at the end of each reporting period and adjusts its remaining estimated liabilities, if necessary.
Impairment of Long-Lived Assets	Impairment of Long-Lived AssetsThe Company assesses long-lived assets for impairment whenever events or changes in circumstances indicate that the carrying amount of an asset or asset group may not be recoverable. Such events include a significant change in the Company’s strategic business objectives and utilization of the assets. As part of the March 2023 Restructuring Plan, the Company commenced restructuring activities that included the decision to operate as a fully-remote company and discontinue research activities while focusing on completing and closing out clinical trials. In anticipation of exiting its leased facilities, the Company committed to a plan to sell all tangible fixed assets located at its leased facilities, consisting primarily of manufacturing and laboratory equipment. In connection with the classification of such assets as held for sale, the carrying value of the tangible fixed assets to be sold was reduced to their estimated fair value, which was determined based on the estimated selling price less costs to sell. In May 2023, the Company modified various operating leases to shorten the accounting lease term. Upon vacating the leased premises in the second quarter of 2023, the Company wrote-off the remaining balances related to right-of-use assets and leasehold improvements.
Cash, Cash Equivalents and Restricted Cash	Cash, Cash Equivalents and Restricted Cash Cash and cash equivalents are held in accounts at financial institutions. As of June 30, 2023, the Company’s cash in deposit accounts were insured by the Federal Deposit Insurance Corporation (FDIC) as the balances were within the FDIC insurance limit of up to $250,000 per depositor at each financial institution. The Company considers all highly liquid investments purchased with original maturities of 90 days or less from the purchase date to be cash equivalents. Cash equivalents consist of amounts invested in money market funds exclusively composed of U.S. government obligations.
Recently Adopted Accounting Pronouncements and Recently Issued Accounting Pronouncements	Recently Adopted Accounting Pronouncements Accounting pronouncements that became effective during the six months ended June 30, 2023 did not have a material impact on the Company’s financial condition, results of operations or cash flows. Recently Issued Accounting Pronouncements There were no new accounting pronouncements issued as of June 30, 2023 that are expected to have a material impact on the Company’s financial condition, results of operations or cash flows.

Summary of Significant Accoun_3

Summary of Significant Accounting Policies (Tables)	6 Months Ended
	Jun. 30, 2023
Accounting Policies [Abstract]
Schedule of Reconciliation of Cash, Cash Equivalents and Restricted Cash	The following table provides a reconciliation of cash, cash equivalents and restricted cash reported within the condensed statements of cash flows (in thousands): June 30, June 30, Cash and cash equivalents $ 22,457 $ 95,830 Restricted cash — 1,025 Total cash, cash equivalents and restricted cash $ 22,457 $ 96,855
Schedule of Reconciliation of Cash, Cash Equivalents and Restricted Cash	The following table provides a reconciliation of cash, cash equivalents and restricted cash reported within the condensed statements of cash flows (in thousands): June 30, June 30, Cash and cash equivalents $ 22,457 $ 95,830 Restricted cash — 1,025 Total cash, cash equivalents and restricted cash $ 22,457 $ 96,855

Fair Value Measurements (Tables

Fair Value Measurements (Tables)	6 Months Ended
	Jun. 30, 2023
Fair Value Disclosures [Abstract]
Summary of Financial Assets Measured at Fair Value on Recurring Basis	The following tables present money market funds at their level within the fair value hierarchy for the periods indicated (in thousands): June 30, 2023 Fair Value Hierarchy Level Amortized Cost Gross Unrealized Gains Gross Unrealized Losses Fair Value Cash equivalents: Money market funds invested in U.S. government obligations Level 1 $ 22,217 $ — $ — $ 22,217 Total $ 22,217 $ — $ — $ 22,217 December 31, 2022 Fair Value Hierarchy Level Amortized Cost Gross Unrealized Gains Gross Unrealized Losses Fair Value Cash equivalents: Money market funds invested in U.S. government obligations Level 1 $ 40,729 $ — $ — $ 40,729 Total $ 40,729 $ — $ — $ 40,729

Balance Sheet Components (Table

Balance Sheet Components (Tables)	6 Months Ended
	Jun. 30, 2023
Balance Sheet Related Disclosures [Abstract]
Schedule of Property, Plant and Equipment, Net	Property and equipment, net, consisted of the following (in thousands): June 30, December 31, Laboratory and manufacturing equipment $ — $ 11,421 Leasehold improvements 221 5,246 Computer and office equipment — 491 Construction in progress — 72 Total property and equipment, gross 221 17,230 Accumulated depreciation (182) (9,047) Total property and equipment, net $ 39 $ 8,183
Schedule of Accrued Liabilities	Accrued expenses consisted of the following (in thousands): June 30, December 31, Professional services $ 1,300 $ 728 Compensation expenses 549 3,985 Research and development expenses — 3,508 Property and equipment — 7 Other 353 432 Total accrued expenses $ 2,202 $ 8,660

Restructuring, Impairment, an_2

Restructuring, Impairment, and Related Charges (Tables)	6 Months Ended
	Jun. 30, 2023
Restructuring and Related Activities [Abstract]
Schedule of Restructuring, Impairment, and Related Charges	The following table details “Restructuring, impairment, and related charges” for each of the periods presented (in thousands): Three Months Ended Six Months Ended 2023 2022 2023 2022 Employee termination benefits $ (41) $ 3,339 $ 5,585 $ 3,339 Stock-based compensation — (419) — (419) Asset impairments 7,748 80 10,642 80 Other related costs 422 787 645 787 Total restructuring, impairments, and related charges $ 8,129 $ 3,787 $ 16,872 $ 3,787 The following table summarizes the charges and spending relating to restructuring program activities for the six months ended June 30, 2023: Employee Termination Benefits Asset Impairments Other Related Costs Total Liability balance at December 31, 2022 $ — $ — $ 420 $ 420 Expense 5,585 10,642 645 16,872 Payments (5,585) (5,250) (1) (1,282) (12,117) Non-cash activity — (5,392) 362 (5,030) Liability balance at June 30, 2023 (2) $ — $ — $ 145 $ 145 (1) Represents cash payments for early termination fees associated with exiting operating leases, which were recorded as increases to right-of-use assets. Upon vacating the leased premises, any remaining balances related to right-of-use assets were written off. (2) The remaining cash outlays related to restructuring programs are expected to be substantially completed by the end of the third quarter of 2023.

Leases (Tables)

Leases (Tables)	6 Months Ended
	Jun. 30, 2023
Leases [Abstract]
Summary of Lease Expense	The following table summarizes total lease expense for the three and six months ended June 30, 2023 and 2022 (in thousands): Condensed Statements of Operations Classification Three Months Ended Six Months Ended 2023 2022 2023 2022 Operating lease expense Operating expenses $ 1,251 $ 2,240 $ 3,216 $ 4,509 Finance lease expense: Amortization of ROU assets Operating expenses 21 56 82 106 Interest on lease liabilities Interest income, net 1 8 8 15 Variable lease expense Operating expenses 322 571 640 1,132 Short-term lease expense Operating expenses — 5 5 67 Sublease income Operating expenses (523) (495) (1,333) (900) Total lease expense $ 1,072 $ 2,385 $ 2,618 $ 4,929
Summary of Supplemental Cash Flow Information	The following table summarizes supplemental cash flow information for the six months ended June 30, 2023 and 2022 (in thousands): Six Months Ended June 30, 2023 2022 Cash paid for amounts included in the measurement of liabilities: Operating cash flows from operating leases $ 3,717 $ 3,299 Operating cash flows from finance leases 8 15 Financing cash flows from finance leases 254 132 Right-of-use asset obtained in exchange for new operating lease liability — 563 Right-of-use asset obtained in exchange for new finance lease liability 114 148
Schedule of Future Minimum Payments and Sublease Income under Noncancelable Leases	The following table summarizes maturities of lease liabilities and sublease income as of June 30, 2023 (in thousands): Operating Leases Sublease Income Payments Net Lease Income Payments 2023 (remaining six months) $ 737 $ (766) $ (29) 2024 1,000 (1,044) (44) Total lease payments (undiscounted) 1,737 $ (1,810) $ (73) Less interest or imputed interest (25) Total present value of lease liabilities 1,712 Less: Lease liabilities, current (1,458) Lease liabilities, non-current $ 254

Common Stock and Stock-Based _2

Common Stock and Stock-Based Compensation (Tables)	6 Months Ended
	Jun. 30, 2023
Share-Based Payment Arrangement [Abstract]
Schedule of Common Stock Reserved for Future Issuance	Common stock reserved for future issuance, on an as converted basis, consisted of the following: June 30, December 31, Stock options outstanding 3,272,024 5,369,808 RSUs and PSUs outstanding 3,474,780 531,366 Shares available for future grants under equity incentive plans 5,551,006 4,654,922 Shares available for issuance under ESPP 1,234,610 872,792 Total 13,532,420 11,428,888
Summary of Components of Stock-Based Compensation Expense	The following table summarizes the components of stock-based compensation expense recognized in the Company’s condensed statements of operations during the three and six months ended June 30, 2023 and 2022 (in thousands): Three Months Ended Six Months Ended 2023 2022 2023 2022 Research and development $ 13 $ 2,859 $ 972 $ 6,295 General and administrative 1,815 3,150 4,079 6,487 Restructuring, impairment, and related charges — (419) — (419) Total stock-based compensation expense $ 1,828 $ 5,590 $ 5,051 $ 12,363
Summary of Stock Option Activity	The following summarizes stock option activity (in thousands, except share, per share, and year amounts): Total Options Outstanding Weighted- Weighted- Aggregate Outstanding as of December 31, 2022 5,369,808 $ 17.28 7.6 $ 11 Granted 768,000 0.39 Exercised — — Canceled (2,865,784) 17.44 Outstanding as of June 30, 2023 3,272,024 $ 13.18 7.2 $ — Exercisable as of June 30, 2023 1,970,466 $ 13.25 6.2 $ —
Summary of Restricted Stock Unit Activity	The following summarizes RSU and PSU activity: RSUs PSUs Number of Shares Weighted- Number of Shares Weighted- Outstanding as of December 31, 2022 531,366 $ 10.12 — $ — Granted — — 3,461,640 0.30 Vested (67,664) 10.64 (149,712) 0.31 Canceled (300,850) 11.04 — — Outstanding as of June 30, 2023 162,852 $ 8.21 3,311,928 $ 0.30

Net Loss Per Share (Tables)

Net Loss Per Share (Tables)	6 Months Ended
	Jun. 30, 2023
Earnings Per Share [Abstract]
Schedule of Computation of Basic and Diluted Net Loss Per Share	The following table sets forth the computation of the basic and diluted net loss per share (in thousands except share and per share data): Three Months Ended Six Months Ended 2023 2022 2023 2022 Numerator: Net loss $ (17,333) $ (35,945) $ (45,250) $ (78,520) Denominator: Weighted-average shares of common stock outstanding used in the calculation of basic and diluted net loss per share 39,333,046 38,748,741 39,261,122 38,695,350 Net loss per share, basic and diluted $ (0.44) $ (0.93) $ (1.15) $ (2.03)
Summary of Weighted Average Potential Shares Excluded from Computation of Diluted Net Loss Per Common Share	Potentially dilutive securities that were not included in the diluted per share calculations because they would be anti-dilutive were as follows: June 30, 2023 2022 Stock options outstanding 3,272,024 6,260,697 RSUs and PSUs outstanding 3,474,780 774,483

Description of Business (Detail

Description of Business (Details) $ in Thousands		1 Months Ended	3 Months Ended				6 Months Ended
	Mar. 27, 2023 employee	Jan. 31, 2022 shares	Jun. 30, 2023 USD ($)	Mar. 31, 2023 USD ($)	Jun. 30, 2022 USD ($)	Mar. 31, 2022 USD ($)	Jun. 30, 2023 USD ($) shares	Jun. 30, 2022 USD ($)	Aug. 14, 2023 employee	Dec. 31, 2022 USD ($)
Business And Principal Activities [Line Items]
Net loss			$ (17,333)	$ (27,917)	$ (35,945)	$ (42,575)	$ (45,250)	$ (78,520)
Accumulated deficit			(411,220)				(411,220)			$ (365,970)
Cash and cash equivalents			$ 22,457		$ 95,830		22,457	$ 95,830		$ 61,145
At The Market | Sales Agreement | Agents
Business And Principal Activities [Line Items]
Shares reserved for issuance of common stock upon initial public offering, net of underwriter's' commission and issuance costs (in shares) | shares		150,000,000
Maximum public float limit to raise capital							$ 75,000
Issuance of common stock upon initial public offering, net of underwriters’ commission and issuance costs (in shares) | shares							0
Subsequent Event
Business And Principal Activities [Line Items]
Number of employees | employee									13
Severance Payments and Other Employee-Related Separation Costs | Reduction in Workforce Plan
Business And Principal Activities [Line Items]
Reduction in number of employees | employee	63
Percentage of reduction in workforce	82%

Summary of Significant Accoun_4

Summary of Significant Accounting Policies - Narrative (Details) - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2023	Jun. 30, 2022	Jun. 30, 2023	Jun. 30, 2022
Reclassification [Line Items]
Restructuring, impairment, and related charges	$ 8,129	$ 3,787	$ 16,872	$ 3,787
Research and development	2,558	22,802	15,546	54,041
General and administrative	$ 7,045	9,433	$ 13,797	20,770
Revision of Prior Period, Reclassification, Adjustment | Research and Development Expense Reclassification to Restructuring, Impairment and Related Charges
Reclassification [Line Items]
Restructuring, impairment, and related charges		3,100		3,100
Research and development		(3,100)
Revision of Prior Period, Reclassification, Adjustment | General and Administrative Expense Reclassification to Restructuring, Impairment and Related Charges
Reclassification [Line Items]
Restructuring, impairment, and related charges		700		700
General and administrative		$ (700)		$ (700)

Summary of Significant Accoun_5

Summary of Significant Accounting Policies - Schedule of Reconciliation of Cash, Cash Equivalents and Restricted Cash (Details) - USD ($) $ in Thousands	Jun. 30, 2023	Dec. 31, 2022	Jun. 30, 2022
Accounting Policies [Abstract]
Cash and cash equivalents	$ 22,457	$ 61,145	$ 95,830
Restricted cash	0	$ 916	1,025
Total cash, cash equivalents and restricted cash	$ 22,457		$ 96,855

Fair Value Measurements - Summa

Fair Value Measurements - Summary of Financial Assets Measured at Fair Value on Recurring Basis (Details) - Fair Value, Recurring - Level 1 - USD ($) $ in Thousands	Jun. 30, 2023	Dec. 31, 2022
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Amortized Cost	$ 22,217	$ 40,729
Gross Unrealized Gains	0	0
Gross Unrealized Losses	0	0
Fair Value	22,217	40,729
Money market funds invest in U.S. government obligations
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Amortized Cost	22,217	40,729
Gross Unrealized Gains	0	0
Gross Unrealized Losses	0	0
Fair Value	$ 22,217	$ 40,729

Balance Sheet Components - Narr

Balance Sheet Components - Narrative (Details) - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2023	Jun. 30, 2022	Jun. 30, 2023	Jun. 30, 2022	Dec. 31, 2022
Balance Sheet Related Disclosures [Abstract]
Prepaid clinical expenses	$ 400		$ 400		$ 1,200
Asset impairments			5,392	$ 80
Depreciation expense	$ 100	$ 800	$ 700	$ 1,700

Balance Sheet Components - Sche

Balance Sheet Components - Schedule of Property, Plant and Equipment, Net (Details) - USD ($) $ in Thousands	Jun. 30, 2023	Dec. 31, 2022
Property Plant And Equipment [Line Items]
Total property and equipment, gross	$ 221	$ 17,230
Accumulated depreciation	(182)	(9,047)
Total property and equipment, net	39	8,183
Laboratory and manufacturing equipment
Property Plant And Equipment [Line Items]
Total property and equipment, gross	0	11,421
Leasehold improvements
Property Plant And Equipment [Line Items]
Total property and equipment, gross	221	5,246
Computer and office equipment
Property Plant And Equipment [Line Items]
Total property and equipment, gross	0	491
Construction in progress
Property Plant And Equipment [Line Items]
Total property and equipment, gross	$ 0	$ 72

Balance Sheet Components - Sc_2

Balance Sheet Components - Schedule of Accrued Liabilities (Details) - USD ($) $ in Thousands	Jun. 30, 2023	Dec. 31, 2022
Balance Sheet Related Disclosures [Abstract]
Professional services	$ 1,300	$ 728
Compensation expenses	549	3,985
Research and development expenses	0	3,508
Property and equipment	0	7
Other	353	432
Total accrued expenses	$ 2,202	$ 8,660

Restructuring, Impairment, an_3

Restructuring, Impairment, and Related Charges - Narrative (Details) $ in Thousands	1 Months Ended		3 Months Ended		6 Months Ended
	Mar. 31, 2023 employee	May 31, 2022 employee	Jun. 30, 2023 USD ($)	Jun. 30, 2022 USD ($)	Jun. 30, 2023 USD ($)	Jun. 30, 2022 USD ($)
Restructuring Cost and Reserve [Line Items]
Employee termination benefits			$ (41)	$ 3,339	$ 5,585	$ 3,339
Non-cash asset impairment charges					5,392	80
Other related costs			422	787	645	787
Loss on disposal of property and equipment					340	0
Gain on partial termination of lease					702	0
Restructuring, impairment, and related charges			8,129	3,787	16,872	3,787
Reduction in stock-based compensation expense			$ 0	419	0	419
March 2023 Restructuring Plan
Restructuring Cost and Reserve [Line Items]
Employee termination benefits					5,600
Non-cash asset impairment charges					5,400
Other related costs					600
Loss on disposal of property and equipment					300
Gain on partial termination of lease					700
May 2022 Restructuring Plan
Restructuring Cost and Reserve [Line Items]
Employee termination benefits				3,300		3,300
Non-cash asset impairment charges				100		100
Other related costs				800		800
Restructuring, impairment, and related charges				3,800		3,800
Reduction in stock-based compensation expense				$ 400		$ 400
Severance Payments and Other Employee-Related Separation Costs | March 2023 Restructuring Plan
Restructuring Cost and Reserve [Line Items]
Percentage of reduction in workforce	82%
Reduction in number of employees | employee	63
Severance Payments and Other Employee-Related Separation Costs | May 2022 Restructuring Plan
Restructuring Cost and Reserve [Line Items]
Percentage of reduction in workforce		40%
Reduction in number of employees | employee		52
Contract Termination Fees | March 2023 Restructuring Plan
Restructuring Cost and Reserve [Line Items]
Other related costs					$ 1,000

Restructuring, Impairment, an_4

Restructuring, Impairment, and Related Charges - Restructuring and Related Charges (Details) - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2023	Jun. 30, 2022	Jun. 30, 2023	Jun. 30, 2022
Restructuring and Related Activities [Abstract]
Employee termination benefits	$ (41)	$ 3,339	$ 5,585	$ 3,339
Stock-based compensation	0	(419)	0	(419)
Asset impairments	7,748	80	10,642	80
Other related costs	422	787	645	787
Total restructuring, impairments, and related charges	$ 8,129	$ 3,787	$ 16,872	$ 3,787

Restructuring, Impairment, an_5

Restructuring, Impairment, and Related Charges - Asset Impairment Charges (Details) $ in Thousands	6 Months Ended
	Jun. 30, 2023 USD ($)
Restructuring Reserve [Roll Forward]
Liability balance at beginning of period	$ 420
Expense	16,872
Payments	(12,117)
Non-cash activity	(5,030)
Liability balance at end of period	145
Employee Termination Benefits
Restructuring Reserve [Roll Forward]
Liability balance at beginning of period	0
Expense	5,585
Payments	(5,585)
Non-cash activity	0
Liability balance at end of period	0
Asset Impairments
Restructuring Reserve [Roll Forward]
Liability balance at beginning of period	0
Expense	10,642
Payments	(5,250)
Non-cash activity	(5,392)
Liability balance at end of period	0
Other Related Costs
Restructuring Reserve [Roll Forward]
Liability balance at beginning of period	420
Expense	645
Payments	(1,282)
Non-cash activity	362
Liability balance at end of period	$ 145

Leases - Narrative (Details)

Leases - Narrative (Details) $ in Thousands	1 Months Ended	6 Months Ended
	May 31, 2023 USD ($) ft²	Jun. 30, 2023 USD ($) ft²	Jun. 30, 2022 USD ($)	Feb. 28, 2021 ft²
Lessee Lease Description [Line Items]
Gain on partial termination of lease		$ 702	$ 0
Weighted average remaining lease term		1 year 2 months 12 days
Weighted average discount rate		2.60%
Minimum
Lessee Lease Description [Line Items]
Finance lease term		3 years
Maximum
Lessee Lease Description [Line Items]
Finance lease term		5 years
Office and Laboratory Space
Lessee Lease Description [Line Items]
Rentable area | ft²		18,748		84,321
Right-of-use asset reduction	$ 10,000
Lease liability reduction	10,700
Gain on partial termination of lease	700
Payment for lease modification	5,300
Security deposit	$ 900
Warehouse Space
Lessee Lease Description [Line Items]
Rentable area | ft²	20,000
Payment for lease modification	$ 800
Security deposit	$ 300

Leases - Summary of Lease Expen

Leases - Summary of Lease Expense (Details) - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2023	Jun. 30, 2022	Jun. 30, 2023	Jun. 30, 2022
Leases [Abstract]
Operating lease expense	$ 1,251	$ 2,240	$ 3,216	$ 4,509
Finance lease expense:
Amortization of ROU assets	21	56	82	106
Interest on lease liabilities	1	8	8	15
Variable lease expense	322	571	640	1,132
Short-term lease expense	0	5	5	67
Sublease income	(523)	(495)	(1,333)	(900)
Total lease expense	$ 1,072	$ 2,385	$ 2,618	$ 4,929

Leases - Summary of Supplementa

Leases - Summary of Supplemental Cash Flow Information (Details) - USD ($) $ in Thousands	6 Months Ended
	Jun. 30, 2023	Jun. 30, 2022
Cash paid for amounts included in the measurement of liabilities:
Operating cash flows from operating leases	$ 3,717	$ 3,299
Operating cash flows from finance leases	8	15
Financing cash flows from finance leases	254	132
Right-of-use asset obtained in exchange for new operating lease liability	0	563
Right-of-use asset obtained in exchange for new finance lease liability	$ 114	$ 148

Leases - Schedule of Maturities

Leases - Schedule of Maturities of Lease Liabilities and Sublease Income (Details) - USD ($) $ in Thousands	Jun. 30, 2023	Dec. 31, 2022
Operating Leases
2023 (remaining six months)	$ 737
2024	1,000
Total lease payments (undiscounted)	1,737
Less interest or imputed interest	(25)
Total present value of lease liabilities	1,712
Less: Lease liabilities, current	(1,458)	$ (4,639)
Lease liabilities, non-current	254	$ 31,228
Sublease Income Payments
2023 (remaining six months)	(766)
2024	(1,044)
Total lease payments (undiscounted)	(1,810)
Net Lease Income Payments
2023 (remaining six months)	(29)
2024	(44)
Total lease payments (undiscounted)	$ (73)

Commitments and Contingencies (

Commitments and Contingencies (Details) $ in Millions	Feb. 28, 2023 USD ($)
Other Commitments [Line Items]
Success fee percentage upon consummation of transaction	3%
Success fee percentage upon consummation of second transaction	3%
Success fee payable upon consummation of second transaction	$ 1.5
Minimum
Other Commitments [Line Items]
Success fee payable upon consummation of transaction	$ 2

Common Stock and Stock-Based _3

Common Stock and Stock-Based Compensation - Additional Information (Details) $ / shares in Units, $ in Millions		1 Months Ended	6 Months Ended
	Jan. 01, 2023 shares	Apr. 30, 2023 shares	Jun. 30, 2023 USD ($) vote $ / shares shares	Dec. 31, 2022 $ / shares shares
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Common stock, shares authorized (in shares)			450,000,000	450,000,000
Common stock, par value (in dollars per share) | $ / shares			$ 0.0001	$ 0.0001
Number of voting rights for each common stock held | vote			1
Total unrecognized stock-based compensation expense related to stock options granted | $			$ 11
Total unrecognized stock-based compensation expense related to nonvested awards weighted average period of recognition			2 years
Consulting agreement term		6 months
RSUs
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Total unrecognized stock-based compensation expense related to nonvested awards weighted average period of recognition			2 years 2 months 12 days
Granted (in shares)			0
Vested (in shares)			67,664
Total stock-based compensation expense related to unvested restricted stock units and awards | $			$ 1.2
ESPP
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Increase in shares available for grant (in shares)	391,818
PSUs
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Granted (in shares)			3,461,640
Vested (in shares)			149,712
Total stock-based compensation expense related to unvested restricted stock units and awards | $			$ 1
PSUs | Director
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Granted (in shares)		886,111
Vested (in shares)			149,712
2020 Plan
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Increase in shares available for grant (in shares)	1,959,090
2020 Plan | PSUs
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Granted (in shares)		2,575,529

Common Stock and Stock-Based _4

Common Stock and Stock-Based Compensation - Schedule of Common Stock Reserved for Future Issuance (Details) - shares	Jun. 30, 2023	Dec. 31, 2022
Class Of Stock [Line Items]
Common stock reserved for future issuance (in shares)	13,532,420	11,428,888
Stock options outstanding
Class Of Stock [Line Items]
Common stock reserved for future issuance (in shares)	3,272,024	5,369,808
RSUs and PSUs outstanding
Class Of Stock [Line Items]
Common stock reserved for future issuance (in shares)	3,474,780	531,366
Shares available for future grants under equity incentive plans
Class Of Stock [Line Items]
Common stock reserved for future issuance (in shares)	5,551,006	4,654,922
ESPP
Class Of Stock [Line Items]
Common stock reserved for future issuance (in shares)	1,234,610	872,792

Common Stock and Stock-Based _5

Common Stock and Stock-Based Compensation - Summary of Components of Stock-Based Compensation Expense (Details) - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2023	Jun. 30, 2022	Jun. 30, 2023	Jun. 30, 2022
Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Line Items]
Total stock-based compensation expense	$ 1,828	$ 5,590	$ 5,051	$ 12,363
Research and development
Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Line Items]
Total stock-based compensation expense	13	2,859	972	6,295
General and administrative
Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Line Items]
Total stock-based compensation expense	1,815	3,150	4,079	6,487
Restructuring, impairment, and related charges
Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Line Items]
Total stock-based compensation expense	$ 0	$ (419)	$ 0	$ (419)

Common Stock and Stock-Based _6

Common Stock and Stock-Based Compensation - Summary of Stock Option Activity (Details) - USD ($) $ / shares in Units, $ in Thousands	6 Months Ended	12 Months Ended
	Jun. 30, 2023	Dec. 31, 2022
Total Options Outstanding
Beginning balance (in shares)	5,369,808
Granted (in shares)	768,000
Exercised (in shares)	0
Cancelled (in shares)	(2,865,784)
Ending balance (in shares)	3,272,024	5,369,808
Options exercisable (in shares)	1,970,466
Weighted- Average Exercise Price
Beginning balance (in dollars per share)	$ 17.28
Granted (in dollars per share)	0.39
Exercised (in dollars per share)	0
Cancelled (in dollars per share)	17.44
Ending balance (in dollars per share)	13.18	$ 17.28
Options exercisable, weighted-average exercise price (in dollars per share)	$ 13.25
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Additional Disclosures [Abstract]
Options outstanding, weighted-average remaining contractual life	7 years 2 months 12 days	7 years 7 months 6 days
Options exercisable, weighted-average remaining contractual life	6 years 2 months 12 days
Options outstanding, aggregate intrinsic value	$ 0	$ 11
Options exercisable, aggregate intrinsic value	$ 0

Common Stock and Stock-Based _7

Common Stock and Stock-Based Compensation - Summary of RSU and PSU Activity (Details)	6 Months Ended
	Jun. 30, 2023 $ / shares shares
RSUs
Number of Shares
Outstanding (in shares) | shares	531,366
Granted (in shares) | shares	0
Vested (in shares) | shares	(67,664)
Cancelled (in shares) | shares	(300,850)
Outstanding (in shares) | shares	162,852
Weighted- Average Grant Date Fair Value per Share
Outstanding (in dollars per share) | $ / shares	$ 10.12
Granted (in dollars per share) | $ / shares	0
Vested (in dollars per share) | $ / shares	10.64
Cancelled (in dollars per share) | $ / shares	11.04
Outstanding (in dollars per share) | $ / shares	$ 8.21
PSUs
Number of Shares
Outstanding (in shares) | shares	0
Granted (in shares) | shares	3,461,640
Vested (in shares) | shares	(149,712)
Cancelled (in shares) | shares	0
Outstanding (in shares) | shares	3,311,928
Weighted- Average Grant Date Fair Value per Share
Outstanding (in dollars per share) | $ / shares	$ 0
Granted (in dollars per share) | $ / shares	0.30
Vested (in dollars per share) | $ / shares	0.31
Cancelled (in dollars per share) | $ / shares	0
Outstanding (in dollars per share) | $ / shares	$ 0.30

Net Loss Per Share - Schedule o

Net Loss Per Share - Schedule of Computation of Basic and Diluted Net Loss Per Share (Details) - USD ($) $ / shares in Units, $ in Thousands	3 Months Ended				6 Months Ended
	Jun. 30, 2023	Mar. 31, 2023	Jun. 30, 2022	Mar. 31, 2022	Jun. 30, 2023	Jun. 30, 2022
Numerator:
Net loss	$ (17,333)	$ (27,917)	$ (35,945)	$ (42,575)	$ (45,250)	$ (78,520)
Denominator:
Weighted-average shares of common stock outstanding used in the calculation of basic net loss per share (in shares)	39,333,046		38,748,741		39,261,122	38,695,350
Weighted-average shares of common stock outstanding used in the calculation of diluted net loss per share (in shares)	39,333,046		38,748,741		39,261,122	38,695,350
Net loss per share, basic (in dollars per share)	$ (0.44)		$ (0.93)		$ (1.15)	$ (2.03)
Net loss per share, diluted (in dollars per share)	$ (0.44)		$ (0.93)		$ (1.15)	$ (2.03)

Net Loss Per Share - Summary of

Net Loss Per Share - Summary of Weighted Average Potential Shares Excluded from Computation of Diluted Net Loss Per Common Share (Details) - shares	6 Months Ended
	Jun. 30, 2023	Jun. 30, 2022
Stock options outstanding
Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items]
Total stock options outstanding	3,272,024	6,260,697
RSUs and PSUs outstanding
Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items]
Total stock options outstanding	3,474,780	774,483