Exhibit 16.1
![](https://capedge.com/proxy/6-K/0001178913-21-003239/image0.jpg)
October 25, 2021
Securities and Exchange Commission
100 F Street, N.E.
Washington, DC 20549
Securities and Exchange Commission
100 F Street, N.E.
Washington, DC 20549
Ladies and Gentlemen:
We have read the Form 6-K dated October 25, 2021 of Painreform Ltd. and are in agreement with the statements contained therein.
/s/ Brightman Almagor Zohar & Co.
Certified Public Accountants
A Firm in the Deloitte Global Network
Tel Aviv, Israel
October 25, 2021
October 25, 2021