Document and Entity Information
Document and Entity Information - USD ($) | 12 Months Ended | ||
Dec. 31, 2021 | Feb. 25, 2022 | Jun. 30, 2021 | |
Cover [Abstract] | |||
Document Type | 10-K | ||
Amendment Flag | false | ||
Document Period End Date | Dec. 31, 2021 | ||
Document Fiscal Year Focus | 2021 | ||
Document Fiscal Period Focus | FY | ||
Trading Symbol | RPTX | ||
Entity Registrant Name | Repare Therapeutics Inc. | ||
Entity Central Index Key | 0001808158 | ||
Entity Well-known Seasoned Issuer | No | ||
Entity Voluntary Filers | No | ||
Entity Current Reporting Status | Yes | ||
Entity Interactive Data Current | Yes | ||
Current Fiscal Year End Date | --12-31 | ||
Entity Filer Category | Large Accelerated Filer | ||
Entity Small Business | false | ||
Entity Emerging Growth Company | false | ||
Entity Shell Company | false | ||
Entity Public Float | $ 812,089,648 | ||
Entity Common Stock, Shares Outstanding | 41,872,369 | ||
Title of 12(b) Security | Common Shares, no par value | ||
Security Exchange Name | NASDAQ | ||
Entity File Number | 001-39335 | ||
Entity Incorporation, State or Country Code | A8 | ||
Entity Tax Identification Number | 00-0000000 | ||
Entity Address, Address Line One | 7210 Frederick-Banting | ||
Entity Address, Address Line Two | Suite 100 | ||
Entity Address, City or Town | St-Laurent | ||
Entity Address, State or Province | QC | ||
Entity Address, Country | CA | ||
Entity Address, Postal Zip Code | H4S 2A1 | ||
City Area Code | 857 | ||
Local Phone Number | 412-7018 | ||
Document Annual Report | true | ||
Document Transition Report | false | ||
ICFR Auditor Attestation Flag | true | ||
Documents Incorporated by Reference | Portions of the definitive proxy statement for the registrant’s 2022 annual meeting of shareholders, which is to be filed within 120 days after the end of the registrant’s fiscal year ended December 31, 2021, are incorporated by reference into Part III of this Form 10-K, to the extent described in Part III. | ||
Auditor Firm ID | 1263 | ||
Auditor Name | Ernst & Young LLP | ||
Auditor Location | Montréal, Canada |
Consolidated Balance Sheets
Consolidated Balance Sheets - USD ($) $ in Thousands | Dec. 31, 2021 | Dec. 31, 2020 |
Current assets: | ||
Cash and cash equivalents | $ 334,427 | $ 326,184 |
Marketable securities | 7,439 | 7,526 |
Research and development tax credits receivable | 2,580 | 2,011 |
Other receivables | 654 | 4,153 |
Prepaid expenses | 6,314 | 6,678 |
Total current assets | 351,414 | 346,552 |
Property and equipment, net | 5,604 | 3,948 |
Restricted cash | 0 | 212 |
Operating lease right-of-use assets | 7,491 | 4,674 |
Other assets | 586 | 288 |
Deferred tax assets | 3,620 | 1,412 |
TOTAL ASSETS | 368,715 | 357,086 |
Current liabilities: | ||
Accounts payable | 2,302 | 2,251 |
Accrued expenses and other current liabilities | 18,622 | 5,975 |
Operating lease liabilities, current portion | 1,721 | 697 |
Deferred revenue, current portion | 11,921 | 2,073 |
Income tax payable | 523 | 18 |
Total current liabilities | 35,089 | 11,014 |
Operating lease liabilities, net of current portion | 5,592 | 3,308 |
Deferred revenue, net of current portion | 39,613 | 55,934 |
TOTAL LIABILITIES | 80,294 | 70,256 |
Commitments and Contingencies (note 17) | ||
SHAREHOLDERS' EQUITY: | ||
Preferred shares, no par value per share; unlimited shares authorized as of December 31, 2021 and December 31, 2020, respectively; 0 shares issued and outstanding as of December 31, 2021, and December 31, 2020, respectively | ||
Common shares, no par value per share; unlimited shares authorized as of December 31, 2021 and December 31, 2020; 41,850,162 and 36,902,924 shares issued and outstanding as of December 31, 2021 and December 31, 2020, respectively | 480,699 | 384,313 |
Additional paid-in capital | 17,988 | 5,875 |
Accumulated deficit | (210,266) | (103,358) |
TOTAL SHAREHOLDERS' EQUITY | 288,421 | 286,830 |
TOTAL LIABILITIES AND SHAREHOLDERS' EQUITY | $ 368,715 | $ 357,086 |
Consolidated Balance Sheets (Pa
Consolidated Balance Sheets (Parenthetical) - $ / shares | 12 Months Ended | |
Dec. 31, 2021 | Dec. 31, 2020 | |
Statement Of Financial Position [Abstract] | ||
Preferred stock par value | $ 0 | $ 0 |
Preferred stock shares authorized | Unlimited | Unlimited |
Preferred stock shares issued | 0 | 0 |
Preferred stock shares outstanding | 0 | 0 |
Common stock par value | $ 0 | $ 0 |
Common stock shares authorized | Unlimited | Unlimited |
Common stock shares issued | 41,850,162 | 36,902,924 |
Common stock shares outstanding | 41,850,162 | 36,902,924 |
Consolidated Statements of Oper
Consolidated Statements of Operations and Comprehensive Loss - USD ($) $ in Thousands | 12 Months Ended | ||
Dec. 31, 2021 | Dec. 31, 2020 | Dec. 31, 2019 | |
Revenue: | |||
Collaboration agreements | $ 7,600 | $ 135 | |
Operating expenses: | |||
Research and development, net of tax credits | 90,047 | 40,091 | $ 20,995 |
General and administrative | 26,213 | 14,346 | 5,382 |
Total operating expenses | 116,260 | 54,437 | 26,377 |
Loss from operations | (108,660) | (54,302) | (26,377) |
Other (expense) income, net | |||
Realized and unrealized (loss) gain on foreign exchange | (144) | (664) | 712 |
Change in fair value of Series A Preferred Share tranche obligation | (1,350) | ||
Interest income | 259 | 240 | |
Other expense | (41) | (16) | (6) |
Total other (expense) income, net | 74 | (440) | (644) |
Loss before income taxes | (108,586) | (54,742) | (27,021) |
Income tax benefit (expense) | 1,678 | 1,325 | (195) |
Net loss and comprehensive loss | (106,908) | (53,417) | (27,216) |
Net loss attributable to common shareholders—basic and diluted | $ (106,908) | $ (53,417) | $ (27,216) |
Net loss per share attributable to common shareholders—basic and diluted | $ (2.83) | $ (2.66) | $ (17.81) |
Weighted-average common shares outstanding—basic and diluted | 37,818,115 | 20,045,602 | 1,528,374 |
Consolidated Statements of Conv
Consolidated Statements of Convertible Preferred Shares and Shareholders' Equity (Deficit) - USD ($) $ in Thousands | Total | 2020 Employee Share Purchase Plan | Initial Public Offering | Follow On Offering | Series A Convertible Preferred Shares | Series B Convertible Preferred Shares | Common Shares | Common Shares2020 Employee Share Purchase Plan | Common SharesInitial Public Offering | Common SharesFollow On Offering | Additional Paid-in Capital | Additional Paid-in Capital2020 Employee Share Purchase Plan | Accumulated Deficit |
Balance at Dec. 31, 2018 | $ (22,384) | $ 1 | $ 340 | $ (22,725) | |||||||||
Temporary equity balance, Shares at Dec. 31, 2018 | 6,813,340 | ||||||||||||
Temporary equity balance, Value at Dec. 31, 2018 | $ 31,873 | ||||||||||||
Balance, Shares at Dec. 31, 2018 | 1,528,374 | ||||||||||||
Issuance of convertible preferred shares, net of issuance costs | $ 21,876 | $ 82,248 | |||||||||||
Issuance of convertible preferred shares, net of issuance costs, Shares | 4,276,795 | 10,468,258 | |||||||||||
Series A Tranche 3 termination | 2,960 | 2,960 | |||||||||||
Share-based compensation expense | 511 | 511 | |||||||||||
Net loss and comprehensive loss | (27,216) | (27,216) | |||||||||||
Balance at Dec. 31, 2019 | (46,129) | $ 1 | 3,811 | (49,941) | |||||||||
Temporary equity balance, Shares at Dec. 31, 2019 | 11,090,135 | 10,468,258 | |||||||||||
Temporary equity balance, Value at Dec. 31, 2019 | $ 53,749 | $ 82,248 | |||||||||||
Balance, Shares at Dec. 31, 2019 | 1,528,374 | ||||||||||||
Exercise of vested stock options | 799 | $ 1,272 | (473) | ||||||||||
Exercise of vested stock options, Shares | 416,157 | ||||||||||||
Share-based compensation expense | 2,537 | 2,537 | |||||||||||
Issuance of common shares | $ 232,043 | $ 232,043 | |||||||||||
Issuance of common shares, Shares | 12,650,000 | ||||||||||||
Conversion of convertible preferred shares into an equivalent number of common shares, Value | 135,997 | $ (53,749) | $ (82,248) | $ 135,997 | |||||||||
Conversion of convertible preferred shares into an equivalent number of common shares, Shares | (11,090,135) | (10,468,258) | 21,558,393 | ||||||||||
Issuance of warrant and conversion into common shares,Value | 15,000 | $ 15,000 | |||||||||||
Issuance of warrant and conversion into common shares, Shares | 750,000 | ||||||||||||
Net loss and comprehensive loss | (53,417) | (53,417) | |||||||||||
Balance at Dec. 31, 2020 | 286,830 | $ 384,313 | 5,875 | (103,358) | |||||||||
Balance, Shares at Dec. 31, 2020 | 36,902,924 | ||||||||||||
Exercise of vested stock options | $ 986 | $ 1,578 | (592) | ||||||||||
Exercise of vested stock options, Shares | 333,996 | 333,996 | |||||||||||
Share-based compensation expense | $ 12,829 | 12,829 | |||||||||||
Issuance of common shares | 113 | $ 94,288 | $ 113 | $ 94,288 | |||||||||
Issuance of common shares, Shares | 3,299 | 4,600,000 | |||||||||||
Issuance of common shares under the 2020 Employee Share Purchase Plan | $ 283 | $ 407 | $ (124) | ||||||||||
Issuance of common shares under the 2020 Employee Share Purchase Plan, Shares | 9,943 | ||||||||||||
Net loss and comprehensive loss | (106,908) | (106,908) | |||||||||||
Balance at Dec. 31, 2021 | $ 288,421 | $ 480,699 | $ 17,988 | $ (210,266) | |||||||||
Balance, Shares at Dec. 31, 2021 | 41,850,162 |
Consolidated Statements of Co_2
Consolidated Statements of Convertible Preferred Shares and Shareholders' Equity (Deficit) (Parenthetical) - USD ($) $ in Thousands | 12 Months Ended | ||
Dec. 31, 2021 | Dec. 31, 2020 | Dec. 31, 2019 | |
Series A Convertible Preferred Shares | |||
Stock issuance costs | $ 5 | ||
Series B Convertible Preferred Shares | |||
Stock issuance costs | $ 248 | ||
Initial Public Offering | |||
Stock issuance costs | $ 20,957 | ||
Follow On Offering | |||
Stock issuance costs | $ 840 |
Consolidated Statements of Cash
Consolidated Statements of Cash Flows - USD ($) $ in Thousands | 12 Months Ended | ||
Dec. 31, 2021 | Dec. 31, 2020 | Dec. 31, 2019 | |
Cash Flows From Operating Activities: | |||
Net loss and comprehensive loss for the year | $ (106,908) | $ (53,417) | $ (27,216) |
Adjustments to reconcile net loss to net cash used in operating activities: | |||
Share-based compensation expense | 12,829 | 2,537 | 511 |
Depreciation expense | 1,471 | 897 | 605 |
Change in fair value of Series A Preferred Shares tranche obligation | 1,350 | ||
Non-cash lease expense | 1,873 | 890 | 362 |
Loss on disposal of property and equipment | 24 | ||
Foreign exchange loss (gain) | 12 | 588 | (629) |
Amortization of premiums on marketable securities | 113 | ||
Deferred tax asset | (2,208) | (1,280) | |
Changes in operating assets and liabilities: | |||
Prepaid expenses | (32) | (6,988) | (466) |
Research and development tax credits receivable | (556) | (909) | (566) |
Other receivables | 3,554 | (2,038) | (1,347) |
Other non-current assets | (298) | 71 | (464) |
Accounts payable | 152 | 17 | 833 |
Accrued expenses and other current liabilities | 11,166 | 4,573 | 611 |
Operating lease liability, current portion | 98 | (225) | 21 |
Income tax payable | 505 | (200) | 218 |
Operating lease liability, net of current portion | (1,118) | (465) | (394) |
Deferred revenue | (6,473) | 49,865 | 8,142 |
Net cash used in operating activities | (85,796) | (6,084) | (18,429) |
Cash Flows From Investing Activities: | |||
Purchase of property and equipment | (1,690) | (2,237) | (1,304) |
Proceeds on disposal of property and equipment | 40 | ||
Proceeds from maturities of marketable securities | 7,450 | ||
Purchase of marketable securities | (7,476) | (7,526) | |
Net cash used in investing activities | (1,676) | (9,763) | (1,304) |
Cash Flows From Financing Activities: | |||
Proceeds from exercise of stock options | 986 | 799 | |
Proceeds from issuance of common stock under the 2020 Employee Share Purchase Plan | 283 | ||
Net proceeds from issuance of common shares in follow-on offering | 94,288 | ||
Proceeds from issuance of warrant | 15,000 | ||
Net proceeds from issuance of common shares in initial public offering | 232,043 | ||
Net cash provided by financing activities | 95,557 | 247,842 | 103,243 |
Effect of exchange rate fluctuations on cash held | (54) | (604) | 566 |
Net Increase In Cash And Cash Equivalents And Restricted Cash | 8,031 | 231,391 | 84,076 |
Cash and cash equivalents and restricted cash at beginning of year | 326,396 | 95,005 | 10,929 |
Cash and cash equivalents and restricted cash at end of year | 334,427 | 326,396 | 95,005 |
Reconciliation Of Cash And Cash Equivalents And Restricted Cash | |||
Cash and cash equivalents | 334,427 | 326,184 | 94,797 |
Restricted cash | 212 | 208 | |
Total cash and cash equivalents and restricted cash | 334,427 | 326,396 | 95,005 |
Supplemental Disclosure Of Cash Flow Information: | |||
Cash interest received | 240 | 216 | |
Cash taxes paid, net | 25 | 156 | 23 |
Property and equipment purchases incurred but not yet paid | 1,719 | 218 | 40 |
Right-of-use assets obtained in exchange for new operating lease liability | $ 4,690 | 4,538 | 1,074 |
Conversion of Series A and B Preferred Shares into common shares | 135,997 | ||
Conversion of warrant into common shares | $ 15,000 | ||
Series A Preferred Shares | |||
Cash Flows From Financing Activities: | |||
Proceeds from issuance of Preferred Shares, net | 20,995 | ||
Series B Preferred Shares | |||
Cash Flows From Financing Activities: | |||
Proceeds from issuance of Preferred Shares, net | $ 82,248 |
Organization and Nature of Busi
Organization and Nature of Business | 12 Months Ended |
Dec. 31, 2021 | |
Organization Consolidation And Presentation Of Financial Statements [Abstract] | |
Organization and Nature of Business | 1. Organization and Nature of Business Repare Therapeutics Inc. (“Repare” or the “Company”) is a precision medicine oncology company focused on the development of synthetic lethality-based therapies to patients with cancer. The Company was incorporated under the Canada Business Corporations Act on September 6, 2016 . On June 23, 2020, immediately prior to the completion of its initial public offering (the “IPO”), the Company was continued as a corporation under the Business Corporations Act (Québec) . On June 12, 2020, the Company effected a 1-for- 6.062 reverse stock split of the Company’s share capital. Accordingly, all common shares, Series A and B convertible preferred shares, stock options and per share amounts in these consolidated financial statements have been retroactively adjusted to reflect the reverse stock split on a retroactive basis for all periods presented. On June 23, 2020, the Company completed its IPO of 12,650,000 of its common shares, including the exercise in full by the underwriters of their option to purchase up to 1,650,000 additional common shares, for aggregate gross proceeds of $ 253.0 million. The Company’s shares began trading on the Nasdaq Global Select Market under the ticker symbol “RPTX” on June 19, 2020. The Company received $ 232.0 million in net proceeds after deducting underwriting discounts and commissions and other offering expenses payable by the Company. Upon closing of the IPO, all outstanding convertible preferred shares converted into 21,558,393 common shares and the outstanding warrant was automatically exercised into 750,000 common shares. In November 2021, the Company completed a follow-on offering of 4,600,000 of its common shares, including the exercise in full by the underwriters of their option to purchase up to 600,000 additional common shares, at a public offering price of $ 22.00 per share, for net proceeds of $ 94.3 million , after deducting underwriting commissions and offering expenses of $ 0.8 million payable by the Company. Since inception, the Company has incurred operating losses. As of December 31, 2021, the Company had an accumulated deficit of $ 210.3 million . The Company does not have any products approved for sale and has financed its operations primarily through equity financings and funding from its collaboration agreements. Based on its current operating plan, the Company expects that its existing cash and cash equivalents and marketable securities on hand will be sufficient to fund its operating and capital expenditures through 2023. There can be no assurance that the Company will be able to obtain additional debt or equity financing, or generate product revenue or revenue from collaboration agreements, on a timely basis or at all. The failure of the Company to obtain sufficient funds on acceptable terms when needed could have a material adverse effect on the Company’s business, results of operations and financial condition. |
Summary of Significant Accounti
Summary of Significant Accounting Policies | 12 Months Ended |
Dec. 31, 2021 | |
Accounting Policies [Abstract] | |
Summary of Significant Accounting Policies | 2. Summary of Significant Accounting Policies Basis of Presentation The accompanying consolidated financial statements have been prepared in conformity with generally accepted accounting principles in the United States of America (“U.S. GAAP”). Any reference in these notes to applicable guidance is meant to refer to the authoritative U.S. GAAP as found in the Accounting Standards Codification (“ASC”) and as amended by Accounting Standards Updates (“ASU”) of the Financial Accounting Standards Board (“FASB”). Principles of Consolidation The accompanying consolidated financial statements of the Company include the accounts of the Company and its wholly-owned subsidiary, Repare Therapeutics USA Inc. (“Repare USA”), which was incorporated under the laws of Delaware on June 1, 2017. The financial statements of Repare USA are prepared for the same reporting period as the parent company, using consistent accounting policies. All intra-group transactions, balances, income, and expenses are eliminated in full upon consolidation. Foreign Currencies The functional currency for the Company and Repare USA is the U.S. dollar (“USD”). Accordingly, transactions denominated in currencies other than the functional currency are measured and recorded in the functional currency at the exchange rate in effect on the date of the transactions. At each consolidated balance sheet date, monetary assets and liabilities denominated in currencies other than the functional currency are remeasured using the exchange rate in effect at that date. Non-monetary assets and liabilities and revenue and expense items denominated in foreign currencies are translated into the functional currency using the exchange rate prevailing at the dates of the respective transactions. Any gains or losses arising on remeasurement are included in the consolidated statement of operations. Segment Information The Company manages its operations as a single operating segment for the purposes of assessing performance and making operating decisions. The Company’s singular focus is the research, development and commercialization of precision oncology drugs targeting specific vulnerabilities of tumors in genetically defined patient populations. Use of Estimates The preparation of consolidated financial statements in conformity with U.S. GAAP requires management to make estimates and assumptions that affect the amounts reported in consolidated financial statements and accompanying notes. Significant estimates and assumptions reflected in these consolidated financial statements include, but are not limited to, estimates related to revenue recognition, accrued research and development expenses, share-based compensation, right-of-use assets and lease liabilities and income taxes. The Company bases its estimates on historical experience and other market specific or other relevant assumptions that it believes to be reasonable under the circumstances. Actual results could differ from those estimates. Estimates are periodically reviewed in light of changes in circumstances, facts and experience. Changes in estimates are recorded in the period in which they become known. COVID-19 Pandemic With the continued spread of the ongoing COVID-19 pandemic, including variants of COVID-19, the Company established a cross-functional task force and has implemented business continuity plans designed to address and mitigate the impact of the COVID-19 pandemic on its employees and its business, including its preclinical studies and its ongoing and planned clinical trials. The Company has taken measures to secure its research and development activities, while work in its laboratories and facilities has been re-organized to reduce risk of COVID-19 transmission. While the Company is experiencing limited financial impacts at this time, given the global economic slowdown, the overall disruption of global healthcare systems and the other risks and uncertainties associated with the COVID-19 pandemic, the Company’s business, financial condition, and results of operations could be materially adversely affected. The Company cannot predict the ultimate impact, if any, of the COVID-19 pandemic related to both known and unknown risks, including future quarantines, closures and other restrictions resulting from the pandemic. The Company continues to monitor the COVID-19 pandemic as it evolves its business continuity plans, clinical development plans and response strategy. As of the date of these financial statements, the Company is not aware of any specific event or circumstance that would require the Company to update its estimates, assumptions and judgments or revise the carrying value of its assets or liabilities. Actual results could differ from these estimates, and any such differences may be material to the Company’s consolidated financial statements. Cash and Cash Equivalents The Company considers all highly liquid investments purchased with original maturities of 90 days or less at acquisition to be cash equivalents. Cash and cash equivalents include cash held in banks and amounts held in money market funds. Marketable Securities The Company classifies marketable debt securities with a remaining maturity of greater than three months when purchased as available-for-sale. Marketable debt securities with a remaining maturity date greater than one year are classified as non-current where the Company has the intent and ability to hold these securities for at least the next 12 months. The Company’s marketable securities consist of U.S. treasury bills with original maturities greater than 90 days. All of the Company’s marketable securities have a contractual maturity of one year or less. The Company considers its investment portfolio of U.S. treasury bills to be available-for-sale. Accordingly, these investments are recorded at fair value, which is based on quoted market prices. Unrealized gains and losses are reported in accumulated other comprehensive items in shareholders’ equity (deficit). Amortization and accretion of premiums and discounts are recorded in interest income (expense). Realized gains or losses on debt securities are included in other income (expense). If any adjustments to fair value reflect a decline in value of the investment, the Company considers all available evidence to evaluate the extent to which the decline is other than temporary and, if so, marks the investment to market on the Company’s statement of operations and comprehensive income (loss). Restricted Cash As of December 31, 2021 and 2020 , restricted cash consisted of nil and $ 0.2 million, respectively, used to secure a letter of credit denominated in a foreign currency for the benefit of the landlord in connection with one of the Company’s lease agreements. Concentrations of Credit Risk and Off-Balance Sheet Risk Financial instruments that potentially expose the Company to concentrations of credit risk consist primarily of cash and cash equivalents. The Company maintains deposits in accredited financial institutions which may periodically exceed insured limits. The Company deposits its cash in financial institutions that it believes have high credit quality and has not experienced any losses on such accounts and does not believe it is exposed to any unusual credit risk beyond the normal credit risk associated with commercial banking relationships. The Company’s exposure to foreign exchange risk is primarily related to fluctuations between the Canadian dollar and the U.S. dollar. There are balances in Canadian dollars which are subject to foreign currency fluctuations relating to the impact of translating to U.S. dollars for financial statement presentation. As of December 31, 2021 and 2020 , the Company had no significant off-balance sheet risk, such as foreign exchange contracts, option contracts or other foreign hedging arrangements. Comprehensive Loss Comprehensive loss includes net loss as well as other changes in shareholders’ equity (deficit) that result from transactions and economic events other than those with shareholders. For each of the years ended December 31, 2021, 2020 and 2019 , comprehensive loss was equal to net loss. Fair Value Measurements Certain assets and liabilities of the Company are carried at fair value under U.S. GAAP. Fair value is defined as the exchange price that would be received for an asset or paid to transfer a liability (an exit price) in the principal or most advantageous market for the asset or liability in an orderly transaction between market participants on the measurement date. Valuation techniques used to measure fair value must maximize the use of observable inputs and minimize the use of unobservable inputs. Financial assets and liabilities carried at fair value are to be classified and disclosed in one of the following three levels of the fair value hierarchy, of which the first two are considered observable and the last is considered unobservable: Level 1 – Quoted prices in active markets for identical assets or liabilities. Level 2 – Observable inputs (other than Level 1 quoted prices), such as quoted prices in active markets for similar assets or liabilities, quoted prices in markets that are not active for identical or similar assets or liabilities, or other inputs that are observable or can be corroborated by observable market data. Level 3 – Unobservable inputs that are supported by little or no market activity that are significant to determining the fair value of the assets or liabilities, including pricing models, discounted cash flow methodologies and similar techniques. To the extent that the valuation is based on models or inputs that are less observable or unobservable in the market, the determination of fair value requires more judgment. Accordingly, the degree of judgment exercised by the Company in determining fair value is greatest for instruments categorized in Level 3. Financial assets and liabilities are classified in their entirety based on the lowest level of input that is significant to the fair value measurement. An entity may choose to measure financial instruments and certain other items at fair value at specified election dates. Subsequent unrealized gains and losses on items for which the fair value option has been elected will be reported in earnings. The estimated fair values of the Company’s cash and cash equivalents, restricted cash, other assets, accounts payable and accrued expenses and other current liabilities approximate their carrying values. The Company’s marketable securities are carried at fair value, determined according to Level 1 inputs in the fair value hierarchy described above. Property and Equipment, Net Property and equipment is stated at historical cost, net of accumulated depreciation. Depreciation is calculated using the straight-line method over the estimated useful lives of the assets, which are as follows: Asset Category Estimated Useful Lives Computer equipment 3 years Office equipment 5 years Laboratory equipment 5 years Leasehold improvements the shorter of the lease term and the useful life When assets are retired or disposed of, the assets and related accumulated depreciation are derecognized from the accounts, and any resulting gain or loss is included in the determination of net loss. Expenditures for maintenance and repairs are recorded to expense as incurred. Impairment of Long-Lived Assets The Company evaluates its finite-lived intangible assets for impairment whenever events or changes in circumstances indicate that the carrying value of assets may not be recoverable. Recoverability of these assets is measured by comparing their carrying value to the future net undiscounted cash flows the assets are expected to generate over their remaining economic life. If such assets are considered impaired, the impairment to be recognized is measured by the amount by which the carrying value of the assets exceeds their fair value. Indefinite-lived intangible assets are tested for impairment annually, or more frequently if indicators of impairment are present. To date, no such impairment losses have been recorded. Leases At the inception of an arrangement, the Company determines whether the arrangement is or contains a lease based on the unique facts and circumstances present in the arrangement. Leases with a term greater than one year are recognized on the consolidated balance sheet as a right-of-use asset and current and non-current lease liabilities, as applicable. Operating lease liabilities and their corresponding right-of-use assets are initially recorded based on the present value of lease payments over the expected remaining lease term. Certain adjustments to the right-of-use asset may be required for items such as incentives received. The interest rate implicit in lease contracts is typically not readily determinable. As a result, the Company utilizes its incremental borrowing rate to discount lease payments, which reflects the fixed rate at which the Company could borrow on a collateralized basis the amount of the lease payments in the same currency, for a similar term, in a similar economic environment. Prospectively, the Company will adjust the right-of-use assets for straight-line rent expense or any incentives received and remeasure the lease liability at the net present value using the same incremental borrowing rate that was in effect as of the lease commencement or transition date. The Company typically only includes an initial lease term in its assessment of a lease arrangement. Options to renew a lease are not included in the Company’s assessment unless there is reasonable certainty that the Company will renew. Assumptions made by the Company at the commencement date are re-evaluated upon occurrence of certain events, including a lease modification. A lease modification results in a separate contract when the modification grants the lessee an additional right of use not included in the original lease and when lease payments increase commensurate with the standalone price for the additional right of use. When a lease modification results in a separate contract, it is accounted for in the same manner as a new lease. In accordance with ASC 842, components of a lease should be split into three categories: lease components, non-lease components and non-components. The fixed and in-substance fixed contract consideration (including any consideration related to non-components) must be allocated based on the respective relative fair values to the lease components and non-lease components. Entities may elect not to separate lease and non-lease components. The Company has elected to account for lease and non-lease components together as a single lease component for all underlying assets and allocate all of the contract consideration to the lease component only. Revenue Recognition The Company recognizes revenue in accordance with ASC 606, Revenue from Contracts with Customers (“ASC 606”). This standard applies to all contracts with customers, except for contracts that are within the scope of other standards, such as leases, insurance, collaboration arrangements and financial instruments. Under ASC 606, an entity recognizes revenue when its customer obtains control of promised goods or services, in an amount that reflects the consideration which the entity expects to receive in exchange for those goods or services. To determine revenue recognition for arrangements that an entity determines are within the scope of ASC 606, the entity performs the following five steps: (i) identify the contract(s) with a customer; (ii) identify the performance obligations in the contract; (iii) determine the transaction price; (iv) allocate the transaction price to the performance obligations in the contract; and (v) recognize revenue when (or as) the entity satisfies a performance obligation. The Company only applies the five-step model to contracts when it is probable that the entity will collect the consideration it is entitled to in exchange for the goods or services it transfers to the customer. At contract inception, once the contract is determined to be within the scope of ASC 606, the Company assesses the goods or services promised within each contract and determines those that are performance obligations and assesses whether each promised good or service is distinct. The Company then recognizes as revenue the amount of the transaction price that is allocated to the respective performance obligation when (or as) the performance obligation is satisfied. The Company enters into collaboration and license agreements, which are within the scope of ASC 606, to discover, develop, manufacture, and commercialize product candidates. The terms of these agreements typically contain multiple promises or obligations, which may include: (i) licenses to compounds directed to specific targets (referred to as “exclusive licenses”) and (ii) research and development activities to be performed on behalf of the collaboration partner related to the licensed targets. Payments to the Company under these agreements may include non-refundable license fees, customer option exercise fees, payments for research activities, reimbursement of certain costs, payments based upon the achievement of certain milestones and royalties on any resulting net product sales. The Company first evaluates license and/or collaboration arrangements to determine whether the arrangement (or part of the arrangement) represents a collaborative arrangement pursuant to ASC 808, Collaborative Arrangements (“ASC 808”), based on the risks and rewards and activities of the parties pursuant to the contractual arrangement. The Company accounts for collaborative arrangements (or elements within the contract that are deemed part of a collaborative arrangement), which represent a collaborative relationship and not a customer relationship, outside the scope of ASC 606. The Company’s collaborations primarily represent revenue arrangements. For the arrangements or arrangement components that are subject to revenue accounting guidance, in determining the appropriate amount of revenue to be recognized as it fulfills its obligations under each of its agreements, the Company applies the five-step model. As part of the accounting for these arrangements, the Company must use significant judgment to determine: a) the number of performance obligations based on the determination under step (ii) above and whether those performance obligations are distinct from other performance obligations in the contract; b) the transaction price under step (iii) above; and c) the stand-alone selling price for each performance obligation identified in the contract for the allocation of transaction price in step (iv) above. The Company uses judgment to determine whether milestones or other variable consideration, except for sales-based royalties, should be included in the transaction price as described further below. The transaction price is allocated to each performance obligation on a relative stand-alone selling price basis, for which the Company recognizes revenue as or when the performance obligations under the contract are satisfied. In determining the stand-alone selling price of a license to the Company’s proprietary technology or a material right provided by a customer option, the Company considers market conditions as well as entity-specific factors, including those factors contemplated in negotiating the agreements as well as internally developed estimates that include assumptions related to the market opportunity, estimated development costs, probability of success and the time needed to commercialize a product candidate pursuant to the license. In validating its estimated stand-alone selling price, the Company evaluates whether changes in the key assumptions used to determine its estimated stand-alone selling price will have a significant effect on the allocation of arrangement consideration between performance obligations. Amounts received prior to revenue recognition are recorded as deferred revenue. Amounts expected to be recognized as revenue within one year following the balance sheet date are classified as current portion of deferred revenue in the accompanying consolidated balance sheets. Amounts not expected to be recognized as revenue within one year following the balance sheet date are classified as deferred revenue, net of current portion. Amounts recognized as revenue, but not yet received or invoiced are generally recognized as contract assets. Exclusive Licenses – If the license to the Company’s intellectual property is determined to be distinct from the other promises or performance obligations identified in the arrangement, which generally include research and development services, the Company recognizes revenue from non-refundable, upfront fees allocated to the license when the license is transferred to the customer and the customer is able to use and benefit from the license. In assessing whether a license is distinct from the other promises, the Company considers relevant facts and circumstances of each arrangement, including the research and development capabilities of the collaboration partner and the availability of the associated expertise in the general marketplace. In addition, the Company considers whether the collaboration partner can benefit from the license for its intended purpose without the receipt of the remaining promises, whether the value of the license is dependent on the unsatisfied promises, whether there are other vendors that could provide the remaining promises and whether it is separately identifiable from the remaining promises. For licenses that are combined with other promises, the Company utilizes judgment to assess the nature of the combined performance obligation and whether the license is the predominant promise within the combined performance obligation to determine whether the combined performance obligation is satisfied over time or at a point in time and, if over time, the appropriate method of measuring progress for purposes of recognizing revenue. If the license is the predominant promise, and it is determined that the license represents functional intellectual property (“IP”), revenue is recognized at the point in time when control of the license is transferred. If it is determined that the license does not represent functional IP, revenue is recognized over time using an appropriate method of measuring progress. Research and Development Services – The obligations under the Company’s collaboration and license agreements generally include research and development services to be performed by the Company to benefit the collaboration partner. For performance obligations that include research and development services, the Company generally recognizes revenue allocated to such performance obligations based on an appropriate measure of progress. The Company utilizes judgment to determine the appropriate method of measuring progress for purposes of recognizing revenue, which is generally an input measure such as costs incurred. The Company evaluates the measure of progress each reporting period and, if necessary, adjusts the measure of performance and related revenue recognition. The measure of progress, and thereby periods of which revenue should be recognized, are subject to estimates by management and may change over the course of the contract. Reimbursements from the partner that are the result of a collaborative relationship with the partner, instead of a customer relationship, such as co-development activities, are recorded as a reduction to research and development expense. Customer Options – The Company’s arrangements may provide a collaborator with the right to acquire additional goods or services in the future. Under these agreements, fees may be due to the Company (i) at the inception of the arrangement as an upfront fee or payment or (ii) upon the exercise of the customer option. If an arrangement is determined to contain customer options that allow the customer to acquire additional goods or services, the goods and services underlying the customer options are not considered to be performance obligations at the outset of the arrangement, as they are contingent upon option exercise. The Company evaluates the customer options for material rights, or options to acquire additional goods or services for free or at a discount. If the customer options are determined to represent a material right, the material right is recognized as a separate performance obligation at the inception of the arrangement. The Company allocates the transaction price to material rights based on the relative stand-alone selling price, which is determined based on the identified discount and the probability that the customer will exercise the option. Amounts allocated to a material right are not recognized as revenue until, at the earliest, the option is exercised or expires. Milestone Payments – At the inception of each arrangement that includes development milestone payments, the Company evaluates whether the milestones are considered probable of being achieved and estimates the amount to be included in the transaction price using the most likely amount method. If it is probable that a significant revenue reversal would not occur, the associated milestone value is included in the transaction price. Milestone payments that are not within the control of the Company or the licensee, such as regulatory approvals, are not considered probable of being achieved until those approvals are received. The Company evaluates factors such as the scientific, clinical, regulatory, commercial, and other risks that must be overcome to achieve the particular milestone in making this assessment. There is considerable judgment involved in determining whether it is probable that a significant revenue reversal would not occur. At the end of each subsequent reporting period, the Company reevaluates the probability of achievement of all milestones subject to constraint and, if necessary, adjusts its estimate of the overall transaction price. Any such adjustments are recorded on a cumulative catch-up basis, which would affect revenues and earnings in the period of adjustment. If a milestone or other variable consideration relates specifically to the Company’s efforts to satisfy a single performance obligation or to a specific outcome from satisfying the performance obligation, the Company generally allocates the milestone amount entirely to that performance obligation once it is probable that a significant revenue reversal would not occur. Royalties – For arrangements that include sales-based royalties, including milestone payments based on a level of sales, and the license is deemed to be the predominant item to which the royalties relate, the Company recognizes revenue at the later of (i) when the related sales occur or (ii) when the performance obligation to which some or all of the royalty has been allocated has been satisfied (or partially satisfied). To date, the Company has not recognized any royalty revenue resulting from any of its licensing arrangements. For a complete discussion of accounting for collaboration revenues, s ee Note 13. Research and Development Expenses Research and development costs are expensed as incurred. The Company’s research and development expenses consist primarily of costs incurred in performing research and development activities, including salaries and other compensation, share-based compensation, fees paid to external service providers, laboratory supplies and costs for facilities and equipment, partially offset by fully refundable research and development tax credits. Non-refundable prepayments for goods or services that will be used or rendered for future research and development activities are deferred and capitalized. Such amounts are expensed as the goods are delivered or the services are performed, or until it is no longer expected that the goods will be delivered, or the services rendered. Accrued and Prepaid Research and Development Expenses The Company has entered into various research and development contracts. The payments to these agreements are recorded as research and development expenses as incurred. The Company records accrued liabilities and prepaid expenses for estimated ongoing research costs. When evaluating the adequacy of the accrued liabilities and prepaid expenses, the Company analyzes progress of the studies, including the phase or completion of events, invoices received and contracted costs. Significant judgements and estimates are made in determining the accrued and prepaid balances at the end of any reporting period. Actual results could differ from the Company’s estimates. Share-Based Compensation The Company accounts for all share-based awards granted to employees and non-employees as share-based compensation expense at fair value. Since the Company’s IPO in June 2020, the fair value of the underlying common shares is based on the trading price of the Company’s common shares. Prior to the Company’s IPO, the Company previously engaged an independent valuation firm to determine the fair value of the underlying common shares. The independent valuation firm used valuation techniques and methods that comply with guidance provided by the American Institute of Certified Public Accountants in its Accounting & Valuation Guide. Each valuation methodology included estimates and assumptions that required the Company’s judgment. These estimates and assumptions included a number of objective and subjective factors in determining the value of the Company’s common shares at each grant date, including: (1) prices paid for the Company’s convertible preferred shares, which the Company has sold to outside investors in arm’s-length transactions, and the rights, preferences and privileges of the Company’s convertible preferred shares and common shares; (2) valuations performed by an independent valuation specialist; (3) the Company’s stage of development; (4) the fact that grants of share-based awards involved illiquid securities in a private company; and (5) the likelihood of achieving a liquidity event for the common shares underlying the share-based awards, such as an initial public offering or sale of the Company, given prevailing market conditions. The measurement date for employee and non-employee awards is the date of grant, and share-based compensation costs are recognized over the employees’ requisite service period, which is the vesting period, on a straight-line basis. The fair value of each stock option grant or purchases under our 2020 Employee Share Purchase Plan (“ESPP”) is estimated on the date of grant using the Black-Scholes option-pricing model, which requires inputs based on certain subjective assumptions, including the expected share price volatility, the expected term of the option, the risk-free interest rate for a period that approximates the expected term of the option and the Company’s expected dividend yield. As there was no public market for its common shares prior to its IPO, the Company determined the volatility for stock option awards granted based on an analysis of reported data for a group of guideline companies that issued options with substantially similar terms. The expected volatility has been determined using a weighted-average of the historical volatility measures of this group of guideline companies. The Company expects to continue to do so until such time as it has adequate historical data regarding the volatility of its own traded share price. For purchases under our ESPP, the historical volatility is used when developing an estimate of expected volatility. The expected term of the Company’s stock options granted to employees and non-employees has been determined utilizing the “simplified” method for awards that qualify as “plain-vanilla” options. In connection with the adoption of ASU No. 2018-07, Compensation—Stock Compensation (“ASU No. 2018-07”), the Company calculated the expected term of non-employee awards using the midpoint between the vesting date and the contractual term, which is consistent with the method used for employee awards. For purchases under our ESPP, the expected term is based on the length of the offering period. The risk-free interest rate is determined by reference to the U.S. Treasury yield curve in effect at the time of grant of the award, for time periods approximately equal to the expected term of the award. The Company has not paid, and does not anticipate paying, cash dividends on its common shares; therefore, the expected dividend yield is assumed to be zero . Share-based compensation is classified in the |
Fair Value Measurements
Fair Value Measurements | 12 Months Ended |
Dec. 31, 2021 | |
Fair Value Disclosures [Abstract] | |
Fair Value Measurements | 3. Fair Value Measurements The following table presents information about the Company’s financial assets and liabilities measured at fair value on a recurring basis and indicates the level of the fair value hierarchy utilized to determine such fair values: Description Financial Assets Quoted Significant Significant (in thousands) As at December 31, 2021 Assets Cash equivalents Money market funds $ 2,535 $ 2,535 $ — $ — Marketable securities U.S. Treasury notes 7,439 7,439 — — Total financial assets $ 9,974 $ 9,974 $ — $ — As at December 31, 2020 Assets Cash equivalents Money market funds $ 2,455 $ 2,455 $ — $ — Marketable securities U.S. Treasury notes 7,526 7,526 — — Total financial assets $ 9,981 $ 9,981 $ — $ — When developing fair value estimates, the Company maximizes the use of observable inputs and minimizes the use of unobservable inputs. When available, the Company uses quoted market prices to measure the fair value. The valuation technique used to measure fair value for the Company’s Level 1 assets is a market approach, using prices and other relevant information generated by market transactions involving identical or comparable assets. If market prices are not available, the fair value measurement is based on models that use primarily market-based parameters including yield curves, volatilities, credit ratings and currency rates. In certain cases where market rate assumptions are not available, the Company is required to make judgements about assumptions market participants would use to estimate the fair value of a financial instrument. During the years ended December 31, 2021 and 2020 , there were no transfers between fair value measure levels. Series A Preferred Share Tranche Obligation The Company determined that its obligation to issue, and the Company’s investors’ obligation to purchase, additional Series A Preferred Shares at a fixed price (i.e., the issuance price) in subsequent tranches following the initial closing of the Series A Preferred Share financing represented a freestanding financial instrument, the Series A Preferred Share Tranche Obligation. The freestanding financial instrument was classified as an asset or liability on the Company’s consolidated balance sheets and initially recorded at fair value, with changes in fair value for each reporting period recognized in other income (expense), net in the consolidated statements of operations and comprehensive loss (Note 9). In connection with the Company’s issuance of the Series A Preferred Shares in June 2017 (Note 9), the Company recognized the Series A Preferred Share Tranche Obligation at the initial fair value which was determined based on significant inputs not observable in the market, which represents a Level 3 measurement within the fair value hierarchy. The fair value of the obligation was estimated based on results of a third-party valuation. This obligation is remeasured prior to the issuance of subsequent tranches and at each subsequent reporting period. As such, the proceeds from the Series A Preferred Share financing were allocated between the Series A Preferred Share Tranche Obligation and Series A Preferred Shares using the residual method, with the Series A Preferred Share Tranche Obligation being recorded at its fair value and the Series A Preferred Shares at the residual value. Each tranche obligation is valued as a forward contract. The values were determined using a probability-weighted present value calculation. In determining the fair values of the tranche obligations, estimates and assumptions impacting fair value included the estimated future values of the Company’s Series A Preferred Shares, discount rates, estimated time to liquidity and probability of each tranche closing. The Company determined the per share future value of the Series A Preferred Shares by back-solving to the initial proceeds of the Series A Preferred Share financing. The Company remeasured each tranche obligation at each reporting period and prior to settlement. The Company recorded other expense of $ 1.35 million for changes in the fair value of the Series A Preferred Share Tranche Obligation in the consolidated statements of operations and comprehensive loss for the year ended December 31, 2019 . Upon completion of the IPO in June 2020, all issued and outstanding Preferred Shares were converted into common shares. |
Cash and Cash Equivalents and M
Cash and Cash Equivalents and Marketable Securities | 12 Months Ended |
Dec. 31, 2021 | |
Investments Debt And Equity Securities [Abstract] | |
Cash and Cash Equivalents and Marketable Securities | 4. Cash and Cash Equivalents and Marketable Securities As of December 31, 2021 and 2020, cash and cash equivalents and marketable securities were comprised of the following: Amortized Cost Unrealized Gains Unrealized Losses Fair Value (in thousands) As at December 31, 2021 Money market funds included in cash and $ 2,535 $ — $ — $ 2,535 Marketable securities: U.S. Treasury notes 7,439 — — 7,439 Total $ 9,974 $ — $ — $ 9,974 As at December 31, 2020 Money market funds included in cash and $ 2,455 $ — $ — $ 2,455 Marketable securities: U.S. Treasury notes 7,526 — — 7,526 Total $ 9,981 $ — $ — $ 9,981 The amortized cost of marketable securities is equal to their fair value. Accordingly, no unrealized gains or losses were recognized in the years ended December 31, 2 0 21, 2020 and 2019 . The maturities of the Company’s money market funds included in cash and cash equivalents, and marketable securities as of December 31, 2021 and 2020 are less than one year. |
Property and Equipment, Net
Property and Equipment, Net | 12 Months Ended |
Dec. 31, 2021 | |
Property Plant And Equipment [Abstract] | |
Property and Equipment, Net | 5. Property and Equipment, Net Property and equipment, net as of December 31, 2021 and 2020 consisted of the following: December 31, 2021 2020 (in thousands) Computer equipment $ 469 $ 301 Office equipment 509 216 Laboratory equipment 5,536 4,718 Leasehold improvements 2,465 706 Total 8,979 5,941 Less: Accumulated depreciation ( 3,375 ) ( 1,993 ) Property and equipment, net $ 5,604 $ 3,948 Depreciation expense recognized was allocated as follows: Year Ended December 31, 2021 2020 2019 (in thousands) Research and development $ 1,325 $ 786 $ 540 General and administration 146 111 65 Depreciation expense $ 1,471 $ 897 $ 605 |
Accrued Expenses and Other Curr
Accrued Expenses and Other Current Liabilities | 12 Months Ended |
Dec. 31, 2021 | |
Payables And Accruals [Abstract] | |
Accrued Expenses and Other Current Liabilities | 6. Accrued Expenses and Other Current Liabilities Accrued expenses and other current liabilities as of December 31, 2021 and 2020 consisted of the following: December 31, 2021 2020 (in thousands) Accrued compensation and benefits $ 4,867 $ 2,771 Accrued research and development expense 11,272 2,584 Accrued professional services 387 436 Accrued property and equipment purchases 1,719 126 Other 377 58 Total accrued expenses and other current liabilities $ 18,622 $ 5,975 |
License Agreements
License Agreements | 12 Months Ended |
Dec. 31, 2021 | |
License Agreements [Abstract] | |
License Agreements | 7. License Agreements In December 2016, as further amended in February 2017 and amended and restated in July 2018, the Company entered into a license agreement (the “NYU Agreement”) with New York University, pursuant to which the Company obtained a worldwide, royalty-bearing, exclusive license under certain patents and know-how of New York University to research, develop and commercialize products covered by such licensed patents. The Company is required to pay New York University an annual non-refundable license fee, which is creditable against future milestone and royalty payments. The Company is required to pay amounts up to approximately $ 6.7 million in the aggregate upon achievement of certain clinical and commercial milestones and pay a low single digit royalty on future net sales of any product covered by a licensed product and a lower-single digit royalty on future net sales of any product not covered by a licensed product. The NYU Agreement expires on the date of expiration of all royalty obligations. Any potential future milestone or royalty payment amounts have no t been accrued at December 31, 2021 and 2020 due to the uncertainty related to the successful achievement of these milestones. |
Leases
Leases | 12 Months Ended |
Dec. 31, 2021 | |
Leases [Abstract] | |
Leases | 8. Leases The Company has historically entered into lease arrangements for its facilities and certain equipment. As of December 31, 2021 , the Company had four operating leases with required future minimum payments. The Company’s leases generally do not include termination or purchase options. Operating Leases In June 2017, and as further amended in 2021, the Company entered into a lease agreement for office and laboratory space in Montréal, Qué bec, for a four-year term, ending in July 2021 which was extended through July 2025 . In November 2017, and as further amended throughout 2018, 2019, 2020 and 2021, the Company entered into a lease agreement for office and laboratory space located in Montréal, Qué bec, for a three-year term ending in October 2020 which was extended through October 2022 . In July 2021, the Company entered into a lease agreement for office space in Cambridge, Massachusetts, for a three-year term ending in December 2024 , which commenced in December 2021. The Company has an option for a three year renewal, which has not been recognized in the Company’s right-of-use asset or lease liability. In November 2019, and as further amended in July 2021, the Company entered into a lease agreement for office and laboratory space for a five-year term located in Montr éal, Qué bec which commenced in September 2020. The Company has an option for a five year renewal, which has not been recognized in the Company’s right-of-use asset or lease liability. As required under the terms of the lease agreement, the Company incurred prepaid rent of $ 1.0 million prior to commencement of the lease term, with the current portion previously accounted for within prepaid expenses and other current assets and the long-term portion accounted for within other assets. As well, as required under the terms of the amended lease agreement, the Company incurred prepaid rent of $ 0.4 million prior to commencement of the lease term which was accounted for within prepaid expenses. As of the commencement of the lease term, this prepaid rent has been reclassified to the right-of-use asset. The following tables contains a summary of the lease costs recognized under ASC 842 and other information pertaining to the Company’s operating leases for the years ended December 31, 2021, 2020 and 2019: December 31, 2021 2020 2019 (in thousands) Operating Leases Lease Cost Operating lease cost $ 2,101 $ 999 $ 411 Short-term lease cost 25 51 12 Variable lease cost 163 161 248 Total lease cost $ 2,289 $ 1,211 $ 671 December 31, 2021 2020 2019 (in thousands, except as specified otherwise) Other Operating Lease Information Operating cash flows for operating leases $ 1,240 $ 802 $ 426 Right-of-use assets obtained in exchange for lease obligations $ 4,690 $ 4,538 $ 1,074 Weighted-average remaining lease term (in years) 3.35 4.50 1.79 Weighted-average discount rate 4.0 % 5.1 % 7.6 % Variable lease costs for the years ended December 31, 2021, 2020 and 2019 include contingent rental usage, common area maintenance and other operating charges. As the Company’s leases do no t provide an implicit rate, the Company utilized its incremental borrowing rate to discount lease payments, which reflects the fixed rate at which the Company could borrow on a collateralized basis the amount of the lease payments in the same currency, for a similar term, in a similar economic environment. Future minimum lease payments under the Company’s operating leases as of December 31, 2021 were as follows: December 31, (in thousands) Maturity of Lease Liabilities 2022 $ 1,982 2023 2,446 2024 2,492 2025 929 Total lease payments $ 7,849 Less: interest ( 536 ) Total lease liabilities $ 7,313 |
Convertible Preferred Shares
Convertible Preferred Shares | 12 Months Ended |
Dec. 31, 2021 | |
Equity [Abstract] | |
Convertible Preferred Shares | 9. Convertible Preferred Shares In June 2017, the Company authorized the issuance of an unlimited number of Series A Preferred Shares with no par value in connection with the sale and issuance of up to 13,237,696 Series A Preferred Shares. The Series A Preferred Share financing was structured to close in three tranches, each contingent upon the achievement of certain specified milestones. In June 2017, in connection with the closing of the first tranche of Series A Preferred Shares, the Company issued 5,906,049 Series A Preferred Shares at $ 4.91 per share for total proceeds of $ 29.0 million, net of issuance costs of $ 0.04 million and converted previously issued and outstanding Convertible Notes amounting to $ 4.5 million issued in October 2016 and April 2017 into 907,291 Series A Preferred Shares. The terms included the obligation of the investors to purchase, and the Company to sell, up to 7,331,647 additional Series A Preferred Shares contingent upon the achievement of certain specified milestones. The Company concluded that the obligation and right to make future issuances of Series A Preferred Shares met the definition of a freestanding financial instrument, as the rights were legally detachable from the Series A Preferred Shares (Note 3). In January 2019, in connection with the closing of the second tranche of Series A Preferred Shares, the Company issued 4,276,795 Series A Preferred Shares at $ 4.91 per share for total gross proceeds of $ 21.0 million, and the liability related to the Series A second tranche obligation was settled and recognized at fair value as Series A Preferred Shares. In August 2019, the Company authorized the issuance of an unlimited number of Series B Preferred Shares with no par value. In September 2019, the Company issued 10,468,258 Series B Preferred Shares to existing and new investors at $ 7.88 per share for total proceeds of $ 82.5 million. In connection with the issuance and sale of Series B Preferred Shares, the Series A third tranche obligation liability was terminated and recognized as additional paid-in-capital. The carrying value of the Series A Preferred Shares was based on the net proceeds received at initial issuance net of the fair value of the Series A Preferred Share Tranche Obligation. At issuance of the first and second tranches, no beneficial conversion features were present. The carrying value of the Series B Preferred Shares was based on the net proceeds received. At initial issuance, no beneficial conversion features were present. Upon completion of the IPO in June 2020, all issued and outstanding Series A and Series B convertible preferred shares were converted into 21,558,393 common shares and the existing classes of Series A and Series B convertible preferred shares were removed. |
Shareholders' Equity
Shareholders' Equity | 12 Months Ended |
Dec. 31, 2021 | |
Equity [Abstract] | |
Shareholders' Equity | 10. Shareholders’ Equity Convertible Preferred Shares The Company’s Series A and Series B convertible preferred shares were convertible on a one-to-one basis into common shares. Upon completion of the IPO, all issued and outstanding Series A and Series B convertible preferred shares were converted into 21,558,393 common shares and the existing class of Series A and Series B convertible preferred shares were removed. Preferred Shares Effective upon the closing of the IPO, the Company authorized for issue an unlimited number of preferred shares, issuable in series, having such designations, rights, privileges, restrictions and conditions, including dividend and voting rights as the board of directors of the Company may determine, and such rights and privileges, including dividend and voting rights, may be superior to those of the common shares. No preferred shares were issued and outstanding as of December 31, 2021 and 2020. Warrant In conjunction with the collaboration and license agreement with Bristol Myers Squibb, the Company entered into a warrant agreement with an affiliate of Bristol Myers Squibb pursuant to which the Company issued a warrant for total proceeds of $ 15.0 million on May 26, 2020. Upon closing of the IPO, the warrant was automatically exercised at the public offering price of $ 20.00 per share into 750,000 common shares of the Company. Common Shares The articles of continuance of the Company authorize an unlimited number of common shares, voting and participating, without par value. Each common share entitles the holder to one vote on all matters submitted to the shareholders for a vote. The holders of common shares are entitled to receive dividends, as may be declared by the board of directors, if any. Through December 31, 2021 , no cash dividends have been declared or paid. On June 23, 2020, the Company completed its IPO of 12,650,000 of its common shares, including the exercise in full by the underwriters of their option to purchase up to 1,650,000 additional common shares, at the public offering price of $ 20.00 per share, for aggregate gross proceeds of $ 253,000 . The Company received $ 232,043 in net proceeds after deducting underwriting discounts and commissions and other offering expenses payable by the Company. Upon closing of the IPO, all outstanding convertible preferred shares converted into 21,558,393 common shares and the outstanding warrant automatically converted into 750,000 common shares. On November 1, 2021, the Company completed a follow-on offering of 4,600,000 of its common shares, including the exercise in full by the underwriters of their option to purchase up to 600,000 additional common shares, at a public offering price of $ 22.00 per share, for net proceeds of $ 94.3 million , after deducting underwriting commissions and offering expenses of $ 0.8 million payable by the Company. |
Share-Based Compensation
Share-Based Compensation | 12 Months Ended |
Dec. 31, 2021 | |
Disclosure Of Compensation Related Costs Sharebased Payments [Abstract] | |
Stock-Based Compensation | 11. Share-Based Compensation 2020 Employee Share Purchase Plan In June 2020, the Company’s board of directors adopted, and the Company’s shareholders approved the 2020 Employee Share Purchase Plan (“ESPP”). The maximum number of common shares that may be issued under the ESPP was initially 327,000 . Additionally, the number of shares reserved and available for issuance under the ESPP will automatically increase each January 1, beginning on January 1, 2021 and each January 1 thereafter through January 31, 2030, by the lesser of (1) 1.0 % of the total number of common shares outstanding on December 31 of the preceding calendar year, (2) 3,300,000 common shares, or (3) such smaller number of common shares as the Company’s board of directors may designate. As of January 1, 2022, the number of common shares that may be issued under the ESPP is 1,104,588 . The ESPP enables eligible employees to purchase common shares of the Company at the end of each offering period at a price equal to 85 % of the fair market value of the shares on the first business day or the last business day of the offering period, whichever is lower. Participation in the ESPP is voluntary. Eligible employees become participants in the ESPP by enrolling in the plan and authorizing payroll deductions. At the end of each offering period, accumulated payroll deductions are used to purchase the Company’s shares at the discounted price. The Company makes no contributions to the ESPP. A participant may withdraw from the ESPP or suspend contributions to the ESPP. If the participant elects to withdraw during an offering, all contributions are refunded as soon as administratively practicable. If a participant elects to withdraw or suspend contributions, they will not be able to re-enroll in the current offering but may elect to participate in future offerings. The ESPP purchases only whole shares of the Company’s shares. The Company’s first ESPP offering period began February 16, 2021 and ended on August 15, 2021, with a second offering period commencing on August 16, 2021. Subsequent offering periods will be on a rolling six-month basis. The Company issued 9,943 common shares under the ESPP during the year ended December 31, 2021 at an average price per share of $ 28.46 . Cash received from purchases under the ESPP for the year ended December 31, 2021 was $ 0.3 million. In February 2022, the Company issued 16,807 common shares under the ESPP at an average price per share of $ 12.71 . The assumptions that the Company used in the Black Scholes option-pricing model to determine the grant date fair value under the ESPP offering were as follows: Year Ended December 31, 2021 Risk-free interest rate 0.05 % Expected term (in years) 0.50 Expected volatility 61.91 % Expected dividend yield 0.00 % The weighted average grant date fair value under the ESPP offering during the year ended December 31, 2021 was $ 10.94 . Option Plan and 2020 Plan In December 2016, as further amended in December 2017 and September 2019, the Company adopted the Repare Therapeutics Inc. Option Plan (the “Option Plan”) for the issuance of stock options and other share-based awards to directors, officers, employees or consultants. The Option Plan authorized up to 4,074,135 shares of the Company’s common shares to be issued. In June 2020, the Company’s board of directors adopted, and the Company’s shareholders approved the 2020 Equity Incentive Plan (the “2020 Plan”). The 2020 Plan became effective on the effective date of the IPO, at which time the Company ceased making awards under the Option Plan. The 2020 Plan allows the Company’s compensation committee to make equity-based and cash-based incentive awards to the Company’s officers, employees, directors and consultants. A total of 3,600,000 common shares were initially reserved for issuance under the 2020 Plan, plus the number of shares (not to exceed 3,807,448 shares) consisting of (i) 298,605 common shares that were available for issuance of awards under the Option Plan at the time the 2020 Plan became effective, which ceased to be available for future issuance under the Option Plan at such time and (ii) any shares subject to outstanding options or other share awards that were granted under the Option Plan that terminate or expire prior to exercise or settlement; are forfeited because of the failure to vest; or are reacquired or withheld (or not issued) to satisfy a tax withholding obligation or the purchase or exercise price. In addition, the number of shares reserved and available for issuance under the 2020 Plan will automatically increase each January 1, beginning on January 1, 2021 and each January 1 thereafter through January 1, 2030, by 5 % of the outstanding number of common shares on the immediately preceding December 31, or such lesser number of shares as determined by the Company’s board of directors. As of January 1, 2022, the number of common shares reserved for issuance under the 2020 Plan is 7,893,585 . The 2020 Plan is administered by the board of directors. The exercise prices, vesting and other restrictions are determined by the board of directors, except that the exercise price per share of stock option may not be less than 100 % of the fair value of the common share on the date of grant, determined based on the average of the daily volume-weighted average trading price of shares on each of the five trading days immediately preceding the date of grant. Stock options awarded under the 2020 Plan expire 10 years after the grant and generally have vesting conditions of 25 % on the first anniversary of the date of grant and 75 % on a monthly basis at a rate of 1/36 th unless otherwise decided by the Company’s board of directors. Option Activity The assumptions that the Company used in the Black Scholes option-pricing model to determine the grant date fair value of stock options granted to employees and non-employees were as follows, presented on a weighted-average basis: Year Ended December 31, 2021 2020 2019 Risk-free interest rate 0.80 % 0.45 % 1.94 % Expected term (in years) 6.00 6.07 6.10 Expected volatility 75.99 % 72.26 % 71.41 % Expected dividend yield 0.00 % 0.00 % 0.00 % The weighted average grant date fair value of stock options granted during the years ended December 31, 2021, 2020 and 2019 was $ 22.49 , $ 11.73 and $ 1.27 , respectively. The following table summarizes the Company’s share option activity: 2021 Number of Weighted Weighted Intrinsic value (in thousands) Outstanding, 4,132,123 $ 6.39 Granted 1,645,416 $ 34.14 Exercised ( 333,996 ) $ 2.96 Forfeited ( 120,952 ) $ 25.26 Outstanding, 5,322,591 $ 14.76 8.15 $ 55,722 Options 2,090,060 $ 6.28 7.47 $ 32,409 Options unvested, 3,232,531 $ 20.24 8.59 $ 23,313 The aggregate intrinsic value of stock options is calculated as the difference between the exercise price of the stock options and the fair value of the Company’s common shares for those stock options that had an exercise price lower than the fair value of the Company’s common shares. The aggregate intrinsic value of options exercised during the years ended December 31, 2021, 2020 and 2019 was $ 8.5 million , $ 5.7 million , and nil , respectively. The total fair value of options vested during the years ended December 31, 2021, 2020 and 2019 was $ 7.4 million , $ 1.3 million and $ 0.3 million , respectively. During the year ended December 31, 2021 , an aggregate of 333,996 options were exercised at a weighted-average exercise price of $ 2.96 per share, for aggregate proceeds of $ 1.0 million . As a result, an amount of $ 0.6 million previously included in additional paid-in-capital related to the exercised options has been credited to common shares and deducted from additional paid-in-capital. In January 2022, the Company granted an aggregate of 2,203,467 stock options to employees under the 2020 Plan, at a weighted average exercise price of $ 15.63 per share. Share-Based Compensation Share-based compensation expense for all awards was allocated as follows: Year Ended December 31, 2021 2020 2019 (in thousands) Research and development $ 5,681 $ 890 $ 250 General and administrative 7,148 1,647 261 Total share-based compensation expense $ 12,829 $ 2,537 $ 511 Share-based compensation expense by type of award was as follows: Year Ended December 31, 2021 2020 2019 (in thousands) Stock options $ 12,632 $ 2,537 $ 511 ESPP 197 - - Total share-based compensation expense $ 12,829 $ 2,537 $ 511 As of December 31, 2021, there was $ 35.9 million of unrecognized share-based compensation expense related to unvested stock options. The unrecognized share-based compensation expense is expected to be recognized over a weighted-average remaining vesting period of 2.1 years as of December 31, 2021 . |
Employee Savings Plan
Employee Savings Plan | 12 Months Ended |
Dec. 31, 2021 | |
Retirement Benefits [Abstract] | |
Employee Savings Plan | 12. Employee Savings Plan The Company has offered our employees in the United States the ability to participate in a 401(k). The Company has also offered our employees in Canada the ability to participate in a registered retirement savings plan. As of January 1, 2021, the Company started making non-matching employer contributions into both of these plans on behalf of participants equal to 3 % of their base salary. The Company has recorded an expense of $ 0.5 million in matching contributions for the year ended December 31, 2021 . |
Collaborations
Collaborations | 12 Months Ended |
Dec. 31, 2021 | |
Organization Consolidation And Presentation Of Financial Statements [Abstract] | |
Collaborations | 13. Collaborations Ono In January 2019, the Company entered into a research services, license and collaboration agreement (the “Ono Agreement”) with Ono Pharmaceutical Co., Ltd. (“Ono”), a Japanese pharmaceutical company, pursuant to which the Company and Ono have agreed to collaborate in the research of potential product candidates targeting Polθ and the development of the Company’s small molecule Polθ inhibitor program. The Company is primarily responsible for carrying out research activities to identify a product candidate, to be licensed to Ono, in accordance with a mutually agreed upon research plan during a research term that will end upon the earlier of the date of the first submission of an Investigational New Drug application (“IND”) in the United States or Japan, or the end of the research term. In the event that Ono elects to collaborate on the subsequent development and commercialization of the proposed product candidate, Ono will be then responsible for such activities in Japan, South Korea, Taiwan, Hong-Kong, Macau and the Association of Southeast Asian Nations (collectively, the “Ono territory”), and the Company will be responsible for all such activities in the rest of the world outside the Ono territory, including the United States, Canada and European Union. In October 2021, the Company and Ono entered into an amendment to the Ono Agreement whereby the research term, as defined in the Ono Agreement, was extended by one year . Under the terms of the Ono Agreement, the Company received non-refundable upfront payments of ¥ 900 million ($ 8.1 million), consisting of an initial upfront fee payment of ¥ 110 million ($ 1.0 million) and an initial upfront research service payment of ¥ 790 million ($ 7.1 million). Additionally, in connection with the research activities to be conducted pursuant to the Ono Agreement, the Company is eligible to receive additional research service payments of up to an aggregate of ¥ 750 million ($ 6.5 million) upon the occurrence of certain specified research triggers. The Company is also entitled to receive clinical, regulatory and commercial milestone payments of up to ¥ 17.21 billion ($ 149.5 million) in the aggregate, plus a tiered percentage royalty on annual net sales in Ono’s Territory ranging from high-single digits to low teens, subject to certain specified reductions. All future milestone payments and royalties are payable in U.S. dollars after conversion from Japanese yen at the then applicable rate. Additionally, upon election by Ono to collaborate on the proposed product candidate, Ono shall be responsible for a specified percentage of research and development costs for the IND-enabling studies of the selected product candidate. The Company assessed the arrangement in accordance with ASC 606 and concluded that Ono is a customer based on the arrangement structure. The Company identified a single performance obligation under the arrangement consisting of the combination of the license to develop and commercialize a selected product candidate targeting Polθ and associated research services. The Company determined that the license and research services are not distinct within the context of the contract, and the license is the predominant good or service. Accordingly, revenue is recognized in accordance with guidance for licenses, and because the license represents functional IP, it is recognized at the point in time control of the license is transferred. The Company determined that the transaction price at the onset of the arrangement is the total upfront payments received in the aggregate amount of $ 8.1 million which is recorded as deferred revenue. The future milestone payments represent variable consideration that is fully constrained at inception of the arrangement as the achievement of the milestone events are highly uncertain. The Company will reevaluate the likelihood of achievement of the milestones at the end of each reporting period and as uncertain events are resolved or other changes in circumstances occur, and, if necessary, adjust its estimate of the transaction price. In October 2021, upon the occurrence of a specified research trigger, the Company became eligible to receive a portion, amounting to ¥ 100 million ($ 0.9 million), of the research service payments provided for in the Ono Agreement. This amount was received in November 2021 and has been added to the transaction price as the consideration was no longer constrained. Should a product candidate be presented for selection in 2022, the Company would be entitled to receive ¥ 450 million (approximately $ 3.9 million). As of December 31, 2021 there was $ 9.0 million classified as current deferred revenue related to the Ono Agreement as the Company considers the completion of its performance obligation under the Ono Agreement as probable as the Company anticipates advancement of a clinical candidate and initiation of IND-enabling studies in the first half of 2022. As of December 31, 2020 there was $ 8.1 million classified as non-current revenue in the consolidated balance sheet. Bristol Myers Squibb In May 2020, the Company entered into a collaboration and license agreement (the "BMS Agreement") with Bristol-Myers Squibb Company (“Bristol-Myers Squibb”), pursuant to which the Company and Bristol Myers Squibb have agreed to collaborate in the research and development of potential new product candidates for the treatment of cancer. The Company is providing Bristol Myers Squibb access to a selected number of its existing screening campaigns and novel campaigns. The Company is responsible for carrying out early-stage research activities directed to identifying potential targets for potential licensing by Bristol Myers Squibb, in accordance with a mutually agreed upon research plan and will be solely responsible for such costs. The collaboration consists of programs directed to both druggable targets and to targets commonly considered undruggable to traditional small molecule approaches. Upon Bristol Myers Squibb’s election to exercise its option to obtain exclusive worldwide licenses for the subsequent development, manufacturing and commercialization of a program, Bristol Myers Squibb will then be solely responsible for all such worldwide activities and costs. The BMS Agreement was subsequently amended in July, September and November 2020 to include additional campaigns to the list of existing campaigns from which Bristol Myers Squibb may select campaigns under the agreement and to enable unblinding of a Bristol Myers Squibb alliance manager in order to streamline the collaboration and selection process. Under the terms of the BMS Agreement, Bristol Myers Squibb paid the Company an initial nonrefundable upfront fee payment of $ 50.0 million in June 2020. The Company is entitled to receive, on a program-by-program basis, option exercise fees ranging in the low six figures depending on the nature of the applicable program. Bristol Myers Squibb also has the right to retain rights to certain back-up programs in exchange for a one-time payment in the low eight figures per program. The Company is also entitled to receive up to $ 301.0 million in total milestones on a program-by-program basis, consisting of $ 176.0 million in the aggregate for certain specified research, development and regulatory milestones and $ 125.0 million in the aggregate for certain specified commercial milestones. The Company is further entitled to a tiered percentage royalty on annual net sales ranging from high-single digits to low-double digits, subject to certain specified reductions. Royalties are payable by Bristol Myers Squibb on a licensed product-by-licensed product and country-by-country basis until the later of the expiration of the last valid claim covering the licensed product in such country, expiration of all applicable regulatory exclusivities in such country for such licensed product and the tenth anniversary of the first commercial sale of such licensed product in such country. On a program-by-program basis, prior to the earlier of such program ceasing to be included under the BMS Agreement and expiration of the last to expire royalty term for such program, the Company, alone and with third parties, is prohibited from researching, developing, manufacturing and commercializing products that are directed to the applicable target for such program. The Company has provided Bristol Myers Squibb with certain, limited rights to first negotiation if the Company determines to divest, license or collaborate with others regarding certain existing programs, including in the event that the Company receives an unsolicited offer to do so. The right of first negotiation expressly excludes any potential change of control transaction, as defined in the agreement. The collaboration term will expire 42 months after the effective date of the agreement. The BMS Agreement will expire, assuming that Bristol Myers Squibb has exercised at least one option for a program, on a licensed product-by-licensed product and country-by-country basis on expiration of the applicable royalty term and in its entirety upon expiration of the last royalty term. Either party may terminate earlier upon an uncured material breach of the BMS agreement by the other party, or the insolvency of the other party. Additionally, Bristol Myers Squibb may terminate the BMS Agreement for any or no reason on a program-by-program basis upon specified written notice. The Company assessed the BMS Agreement in accordance with ASC 606, Revenue from Contracts with Customers , and concluded that Bristol Myers Squibb is a customer based on the agreement structure. At inception, the Company identified several performance obligations under the BMS Agreement, being (i) research activities for each campaign over the collaboration term, as well as (ii) a selected number of material rights associated with options to obtain exclusive development, manufacturing, and commercial licenses to targets identified. The Company determined that the options to obtain the exclusive development, manufacturing and commercialization licenses were material rights under ASC 606 because there are minimal amounts to be paid to the Company upon exercise of such options. The Company determined that the transaction price at the onset of the BMS Agreement is the total non-refundable upfront payment received of $ 50.0 million. Additional consideration is to be paid to the Company upon the exercise of options to license targets and future milestone payments. The Company utilized the most likely method approach and concluded that these amounts were constrained as they represent option fees and milestone payments that can only be achieved subsequent to option exercises. As such, the Company excluded this additional consideration from the transaction price. The Company has allocated the transaction price of $ 50.0 million to each performance obligation based on the relative stand-alone selling price of each performance obligation at inception, which was determined based on each performance obligation’s estimated stand-alone selling price. The Company has determined the estimated stand-alone selling price at contract inception of the research activities based on internal estimates of the costs to perform the services, inclusive of a reasonable profit margin. Significant inputs used to determine the total costs to perform the research activities included the length of time required, the internal hours expected to be incurred on the services and the number and costs of various studies that will be performed to complete the research plan. The Company determined the estimated stand-alone selling price at contract inception of the material rights associated with options to obtain exclusive licenses to druggable targets and undruggable targets based on the fees Bristol Myers Squibb would pay to exercise these options, the probability-weighted value of expected future cash flows associated with each license related to each target and the probability that these options would be exercised by Bristol Myers Squibb. In developing such estimates, the Company also considered applicable market conditions and relevant entity-specific factors, including those factors contemplated in negotiating the agreement, probability of success and the time needed to commercialize a product candidate pursuant to the associated license. Based on the relative stand-alone selling price, the allocation of the transaction price to the separate performance obligations was as follows: Performance obligation Transaction price (in thousands) Research activities $ 6,405 Options to license druggable targets 31,148 Options to license undruggable targets 12,447 Total transaction price $ 50,000 Revenue associated with the options has been deferred and will be recognized at the point in time when options to license are exercised by Bristol Myers Squibb or upon expiry of such options. Revenue associated with the research activities has been deferred and will be recognized on a proportional performance basis over the period of service for research activities, being the collaboration term, using input-based measurements of total costs of research incurred to estimated proportion performed. Progress towards completion is remeasured at the end of each reporting period. During the years ended December 31, 2021, 2020 and 2019 , the Company recognized $ 1.1 million, $ 0.1 million and nil , respectively, as revenue associated with the BMS Agreement in relation to research activities performed. In October 2021, the Company received notification from Bristol Myers Squibb of their option exercise for two druggable targets directed at a single synthetic lethal lesion, pursuant to the terms of the BMS Agreement. As a result, the Company recognized $ 6.5 million as revenue in the year ended December 31, 2021 with regards to the achievement of the performance obligation from Bristol Meyers Squibb and the related option fees received. No amounts were recognized in the years ended December 31, 2020 and 2019. As of December 31, 2021, there was $ 42.5 million (December 31, 2020 - $ 49.9 million ) of deferred revenue related to the BMS Agreement, of which $ 2.9 million (December 31, 2020 - $ 2.1 million ) was classified as current and $ 39.6 million (December 31, 2020 - $ 47.8 million ) as non-current in the consolidated balance sheet based on the period the services are expected to be performed. In conjunction with entry into the BMS Agreement, the Company entered into a warrant agreement with an affiliate of Bristol Myers Squibb pursuant to which the Company issued a warrant for total proceeds of $ 15.0 million. Upon closing of the IPO, this warrant was automatically exercised into 750,000 common shares of the Company. The Company evaluated whether the warrant should be treated as a separate agreement or a single arrangement with the BMS Agreement. Although the warrant agreement was negotiated concurrently with the BMS Agreement, the warrant was issued at fair value. Accordingly, the Company accounted for the warrant agreement separately from the BMS Agreement. |
Income Taxes
Income Taxes | 12 Months Ended |
Dec. 31, 2021 | |
Income Tax Disclosure [Abstract] | |
Income Taxes | 14. Income Taxes Loss before the provision for income taxes consisted of the following: Year Ended December 31, 2021 2020 2019 (in thousands) Canada $ ( 110,433 ) $ ( 55,446 ) $ ( 27,355 ) Foreign $ 1,847 $ 704 $ 334 Loss before provision for income taxes $ ( 108,586 ) $ ( 54,742 ) $ ( 27,021 ) The components of the provision for income taxes are as follows: Year Ended December 31, 2021 2020 2019 (in thousands) Current income tax provision - foreign $ 530 $ ( 45 ) $ 327 Deferred income tax benefit - foreign ( 2,208 ) ( 1,280 ) ( 132 ) Total provision for income taxes $ ( 1,678 ) $ ( 1,325 ) $ 195 A reconciliation between tax expense and the product of accounting income multiplied by the statutory income tax rate is as follows: Year Ended December 31, 2021 2020 2019 (in thousands) Loss before income taxes $ ( 108,586 ) $ ( 54,742 ) $ ( 27,021 ) Income tax at statutory rate 26.5 % 26.5 % 26.5 % Computed income tax recovery ( 28,775 ) ( 14,507 ) ( 7,160 ) Effect on income tax resulting from: Federal investment tax credit ( 4,093 ) ( 2,347 ) ( 985 ) Accounting charges not deductible for tax purposes 1,078 1,088 143 Equity compensation 2,220 ( 742 ) 134 Other 644 ( 306 ) ( 16 ) Change in valuation allowance 27,248 15,489 8,079 Tax (benefit) expense $ ( 1,678 ) $ ( 1,325 ) $ 195 The Company's applicable statutory tax rate is the Canadian combined rate applicable in the jurisdictions in which the Company operates. During the year ended December 31, 2020, the Company applied operating loss carryforwards to offset taxable income in Canada, arising primarily from the upfront payment received from the collaboration agreement with Bristol Myers Squibb. As of December 31, 2021, the Company had tax losses of approximate ly $ 113.6 mill ion, which are available to offset future taxable income in Canada. The Company has not recognized the tax benefit of these losses. These losses expire as follows: (in thousands) 2041 $ 94,231 2040 — 2039 11,394 2038 7,052 2037 883 Total $ 113,560 As of December 31, 2021, the Company had Scientific Research and Experimental Development (“SR&ED”) expenditures of approximate ly $ 40.2 million for Canadian federal and Québec purposes, which have not been deducted. These expenditures are available to reduce future taxable income and have an unlimited carryforward period. SR&ED expenditures are subject to verification by the tax authorities and, accordingly, the amounts may vary. As of December 31, 2021, the Company had non-refundable Canadian federal investment tax credits of approxima tely $ 6.5 millio n, which may be utilized to reduce Canadian federal income taxes payable. The Company has not recognized the tax benefits related to the non-refundable investment tax credits. The investment tax credits expire as follows: (in thousands) 2041 $ 2,217 2040 1,702 2039 1,362 2038 776 2037 455 2036 24 Total $ 6,536 As of December 31, 2021, the Company had U.S. federal research and development credit carryforwards of approxi mately $ 1.5 million, which begin to expire in 2041 . As of December 31, 2021 , the Company also had U.S. state research and development credit carryforwards of approximately $ 0.3 million, which expire in 2036 . The Company’s deferred tax assets as of December 31, 2021 and 2020 consisted of the following: 2021 2020 (in thousands) Net operating loss carryforwards $ 30,093 $ 5,087 Net research and development expenditures 10,656 7,478 Share issuance costs 3,538 4,506 Net federal investment tax credits 4,805 3,181 U.S. research and development tax credits 1,775 961 Tax basis of property and equipment in excess of carrying values — ( 86 ) Operating lease right-of-use assets ( 1,995 ) ( 1,240 ) Operating lease liability 1,950 1,063 Accrued expense and other liabilities 760 345 Deferred revenue 13,656 15,372 Share-based compensation 988 103 Total deferred tax assets 66,226 36,770 Valuation allowance ( 62,606 ) ( 35,358 ) Net deferred tax assets $ 3,620 $ 1,412 The Company files income tax returns in Canada and in the United States. In the normal course of business, the Company could be subject to examination by federal and provincial or state jurisdictions, where applicable. There are currently no pending tax examinations. The Company may be subject to tax examination for 2017, 2018, 2019, 2020 and 2021 due to unexpired statute of limitation periods. The calculation of the Company’s tax liabilities involves dealing with uncertainties in the application of complex tax laws and regulations for both federal taxes and the provinces and states in which the Company operates or does business in. ASC 740 states that a tax benefit from an uncertain tax position may be recognized when it is more likely than not that the position will be sustained upon examination, including resolutions of any related appeals or litigation processes, on the basis of the technical merits. The Company records uncertain tax positions as liabilities in accordance with ASC 740 and adjusts these liabilities when the Company’s judgment changes as a result of the evaluation of new information not previously available. Because of the complexity of some of these uncertainties, the ultimate resolution may result in a payment that is materially different from the current estimate of the unrecognized tax benefit liabilities. These differences will be reflected as increases or decreases to income tax expense in the period in which new information is available. As of December 31, 2021 and 2020 , no uncertain tax positions have been recorded in the consolidated financial statements. The Company recognizes interest and penalties related to unrecognized tax benefits on the income tax expense line in the accompanying consolidated statement of operations and comprehensive loss. As of December 31, 2021 and 2020 , no accrued interest or penalties are included on the related tax liability line in the consolidated balance sheet. |
Net Loss per Share
Net Loss per Share | 12 Months Ended |
Dec. 31, 2021 | |
Earnings Per Share [Abstract] | |
Net Loss per Share | 15. Net Loss per Share The following table summarizes the computation of basic and diluted net loss per share attributable to common shareholders of the Company: Year Ended December 31, 2021 2020 2019 (in thousands, except share and per share data) Numerator: Net loss attributable to common shareholders $ ( 106,908 ) $ ( 53,417 ) $ ( 27,216 ) Net loss attributable to common shareholders—basic and diluted $ ( 106,908 ) $ ( 53,417 ) $ ( 27,216 ) Denominator: Weighted-average number of common shares outstanding— 37,818,115 20,045,602 1,528,374 Net loss per share attributable to common shareholders— $ ( 2.83 ) $ ( 2.66 ) $ ( 17.81 ) The Company’s potentially dilutive securities, which include Convertible Preferred Shares and stock options, have been excluded from the computation of diluted net loss per share attributable to common shareholders as the effect would be to reduce the net loss per share attributable to common shareholders. Therefore, the weighted average number of common shares outstanding used to calculate both basic and diluted net loss per share attributable to common shareholders is the same. The Company excluded the following potential common shares, presented based on amounts outstanding at each period end, from the computation of diluted net loss per share attributable to common shareholders for the periods indicated because including them would have had an anti-dilutive effect: Year Ended December 31, 2021 2020 2019 Series A preferred shares — — 11,090,135 Series B preferred shares — — 10,468,258 Options to purchase common shares 5,322,591 4,132,123 3,505,119 |
Government Assistance
Government Assistance | 12 Months Ended |
Dec. 31, 2021 | |
Research And Development [Abstract] | |
Government Assistance | 16. Government Assistance The Company incurred research and development expenditures which are eligible for refundable investment tax credits. The refundable investment tax credits recorded are based on management’s estimates of amounts expected to be recovered and are subject to audit by the taxation authorities. These amounts have been recorded as a reduction of research and development expenditures in the amounts of $ 1.1 million , $ 0.9 million and $ 0.6 million for the years ended December 31, 2021, 2020 and 2019 , respectively. |
Commitments and Contingencies
Commitments and Contingencies | 12 Months Ended |
Dec. 31, 2021 | |
Commitments And Contingencies Disclosure [Abstract] | |
Commitments and Contingencies | 17. Commitments and Contingencies The following table summarizes the Company’s commitments to settle contractual obligations at December 31, 2021, other than leases which are recognized as operating lease liabilities in the consolidated balance sheet. Year Ending December 31, (in thousands) 2022 $ 2,449 2023 2,333 2024 2,349 2025 33 2026 49 Following years 32 Total $ 7,245 The commitment amounts in the table above are associated with contracts that are enforceable and legally binding and that specify all significant terms, including fixed or minimum services to be used, fixed, minimum or variable price provisions, and the approximate timing of the actions under the contracts. Collaboration and Research Agreements Collaboration and research agreement obligations primarily relate to a strategic collaboration agreement that was entered into with the University of Texas M. D. Anderson Cancer Center (“MDACC”) in March 2020. The collaboration consists of preclinical studies and clinical trials designed by the Company and MDACC with the research to be completed by MDACC. The Company has agreed to commit $ 10.0 million in funding for various studies over a period of five years , of which $ 3.0 million was paid as of December 31, 2021. Purchase and Other Obligations In the normal course of business, the Company enters into contracts with Contract Research Organizations (“CROs”) and other third parties for preclinical studies and clinical trials, research and development supplies and other testing and manufacturing services. These contracts generally do not contain minimum purchase commitments and provide for termination on 30 to 90 days’ prior written notice, and therefore are cancellable contracts. These payments are not included in the table above as the amount and timing of such payments are not known as of December 31, 2021. In the normal course of business, the Company also entered into a research and development service agreement with a third party, which provides for potential milestone payments by the Company, contingent on the achievement of clinical development milestones. The maximum amount that would be paid if all milestones, however unlikely, are achieved is $ 1.75 million. This agreement also requires termination payments of up to $ 0.5 million should the Company cancel the agreement without cause prior to completion of certain research and development services. These payments are not included in the table above as they entail uncertainties in relation to the amount and timing of such payments as they are dependent on milestone achievements or termination. The Company has further entered into license agreements under which it is obligated to make milestone and royalty payments and incur annual maintenance fees. The future milestone or royalty payments under these agreements have not been included in the table above since the payment obligations are contingent upon future events, such as achieving certain clinical and commercial milestones or generating product sales. As of December 31, 2021, the Company is unable to estimate the timing or likelihood of achieving these clinical and commercial milestones or generating future product sales (see Note 7). Indemnification Agreements In the ordinary course of business, the Company may provide indemnification of varying scope and terms to vendors, lessors, business partners and other parties with respect to certain matters including, but not limited to, losses arising out of breach of such agreements or from intellectual property infringement claims made by third parties. In addition, the Company has entered into indemnification agreements with members of its board of directors and executive officers that will require the Company, among other things, to indemnify them against certain liabilities that may arise by reason of their status or service as directors or officers. The maximum potential amount of future payments the Company could be required to make under these indemnification agreements is, in many cases, unlimited. To date, the Company has not incurred any material costs as a result of such indemnifications. The Company is not aware of any indemnification arrangements that could have a material effect on its financial position, results of operations or cash flows, and it has not accrued any liabilities related to such obligations in these consolidated financial statements as at December 31, 2021 . |
Currency Risk
Currency Risk | 12 Months Ended |
Dec. 31, 2021 | |
Foreign Currency Risk [Abstract] | |
Currency Risk | 18. Currency Risk The Company is exposed to the financial risk related to the fluctuation of foreign exchange rates and the degree of volatility of those rates. The foreign currency risk is limited to the portion of the Company’s business transactions denominated in currency other than U.S. dollars. The Company incurs a portion of its expenses in Canadian dollars, as well as other currencies to a lesser extent. A change in the currency exchange rates between the U.S. dollars relative to the Canadian dollar could have a significant effect on the Company’s consolidated results of operations, financial position, or cash flows. The Company does not enter into arrangements to hedge its currency risk exposure, although it maintains expected Canadian dollar cash requirements in Canadian dollars to form a natural hedge. The Company is exposed to currency risk through its cash, research and development tax credits receivable, other receivables, accounts payable, accrued expenses and other current liabilities, as well as right-of-use lease liabilities denominated in Canadian dollars as follows: December 31, 2021 2020 (in thousands) Cash $ 3,583 $ 1,715 Restricted cash — 270 Research and development tax credits receivable 3,261 2,559 Other receivables 745 5,228 Accounts payable ( 665 ) ( 1,322 ) Accrued expenses and other current liabilities ( 2,116 ) ( 2,722 ) Lease liabilities ( 5,564 ) ( 4,847 ) Net financial position exposure $ ( 756 ) $ 881 Based on the above net exposure at December 31, 2021 , and assuming that all other variables remain constant, a 10 % depreciation of the U.S. dollar against the Canadian dollar would result in an increase of $ 0.1 million in the Company’s net loss for the year ended December 31, 2021. The Company is also exposed to currency risk through the Ono Agreement as future payments receivable under its collaboration with Ono, if any, are denominated in Japanese yen. |
Related Parties
Related Parties | 12 Months Ended |
Dec. 31, 2021 | |
Related Party Transactions [Abstract] | |
Related Parties | 19. Related Parties Details of transactions between the Company and other related parties are disclosed below and in other notes according to the nature of the transactions. All transactions are measured at the exchange amount, which is the amount of consideration determined and agreed to by the related parties. For the year ended December 31, 2019, the Company recorded expenses of $ 1.3 million for research services and rent paid by the Company to entities affiliated with a shareholder. No expense was recorded for the years ended December 31, 2021 and 2020 . As of December 31, 2021 and 2020, there was no balances recorded in accounts payable and accrued expense and other current liabilities owed to entities affiliated with a shareholder. |
Geographic Information
Geographic Information | 12 Months Ended |
Dec. 31, 2021 | |
Segment Reporting [Abstract] | |
Geographic Information | 20. Geographic Information The Company’s property and equipment, net by location was as follows: December 31, 2021 2020 (in thousands) Canada $ 3,675 $ 3,845 United States 1,929 103 Total property and equipment, net $ 5,604 $ 3,948 The Company’s right-of-use assets by location were as follows: December 31, 2021 2020 (in thousands) Canada $ 4,939 $ 4,483 United States 2,552 191 Total right-of-use assets, net $ 7,491 $ 4,674 The Company's revenue of $ 7.6 million, $ 0.1 million and nil for the years ended December 31, 2021, 2020 and 2019, respectively, were generated by the Canadian parent company with a customer located in the United States. |
Summary of Significant Accoun_2
Summary of Significant Accounting Policies (Policies) | 12 Months Ended |
Dec. 31, 2021 | |
Accounting Policies [Abstract] | |
Basis of Presentation | Basis of Presentation The accompanying consolidated financial statements have been prepared in conformity with generally accepted accounting principles in the United States of America (“U.S. GAAP”). Any reference in these notes to applicable guidance is meant to refer to the authoritative U.S. GAAP as found in the Accounting Standards Codification (“ASC”) and as amended by Accounting Standards Updates (“ASU”) of the Financial Accounting Standards Board (“FASB”). |
Principles of Consolidation | Principles of Consolidation The accompanying consolidated financial statements of the Company include the accounts of the Company and its wholly-owned subsidiary, Repare Therapeutics USA Inc. (“Repare USA”), which was incorporated under the laws of Delaware on June 1, 2017. The financial statements of Repare USA are prepared for the same reporting period as the parent company, using consistent accounting policies. All intra-group transactions, balances, income, and expenses are eliminated in full upon consolidation. |
Foreign Currencies | Foreign Currencies The functional currency for the Company and Repare USA is the U.S. dollar (“USD”). Accordingly, transactions denominated in currencies other than the functional currency are measured and recorded in the functional currency at the exchange rate in effect on the date of the transactions. At each consolidated balance sheet date, monetary assets and liabilities denominated in currencies other than the functional currency are remeasured using the exchange rate in effect at that date. Non-monetary assets and liabilities and revenue and expense items denominated in foreign currencies are translated into the functional currency using the exchange rate prevailing at the dates of the respective transactions. Any gains or losses arising on remeasurement are included in the consolidated statement of operations. |
Segment Information | Segment Information The Company manages its operations as a single operating segment for the purposes of assessing performance and making operating decisions. The Company’s singular focus is the research, development and commercialization of precision oncology drugs targeting specific vulnerabilities of tumors in genetically defined patient populations. |
Use of Estimates | Use of Estimates The preparation of consolidated financial statements in conformity with U.S. GAAP requires management to make estimates and assumptions that affect the amounts reported in consolidated financial statements and accompanying notes. Significant estimates and assumptions reflected in these consolidated financial statements include, but are not limited to, estimates related to revenue recognition, accrued research and development expenses, share-based compensation, right-of-use assets and lease liabilities and income taxes. The Company bases its estimates on historical experience and other market specific or other relevant assumptions that it believes to be reasonable under the circumstances. Actual results could differ from those estimates. Estimates are periodically reviewed in light of changes in circumstances, facts and experience. Changes in estimates are recorded in the period in which they become known. |
COVID-19 Pandemic | COVID-19 Pandemic With the continued spread of the ongoing COVID-19 pandemic, including variants of COVID-19, the Company established a cross-functional task force and has implemented business continuity plans designed to address and mitigate the impact of the COVID-19 pandemic on its employees and its business, including its preclinical studies and its ongoing and planned clinical trials. The Company has taken measures to secure its research and development activities, while work in its laboratories and facilities has been re-organized to reduce risk of COVID-19 transmission. While the Company is experiencing limited financial impacts at this time, given the global economic slowdown, the overall disruption of global healthcare systems and the other risks and uncertainties associated with the COVID-19 pandemic, the Company’s business, financial condition, and results of operations could be materially adversely affected. The Company cannot predict the ultimate impact, if any, of the COVID-19 pandemic related to both known and unknown risks, including future quarantines, closures and other restrictions resulting from the pandemic. The Company continues to monitor the COVID-19 pandemic as it evolves its business continuity plans, clinical development plans and response strategy. As of the date of these financial statements, the Company is not aware of any specific event or circumstance that would require the Company to update its estimates, assumptions and judgments or revise the carrying value of its assets or liabilities. Actual results could differ from these estimates, and any such differences may be material to the Company’s consolidated financial statements. |
Cash and Cash Equivalents | Cash and Cash Equivalents The Company considers all highly liquid investments purchased with original maturities of 90 days or less at acquisition to be cash equivalents. Cash and cash equivalents include cash held in banks and amounts held in money market funds. |
Marketable Securities | Marketable Securities The Company classifies marketable debt securities with a remaining maturity of greater than three months when purchased as available-for-sale. Marketable debt securities with a remaining maturity date greater than one year are classified as non-current where the Company has the intent and ability to hold these securities for at least the next 12 months. The Company’s marketable securities consist of U.S. treasury bills with original maturities greater than 90 days. All of the Company’s marketable securities have a contractual maturity of one year or less. The Company considers its investment portfolio of U.S. treasury bills to be available-for-sale. Accordingly, these investments are recorded at fair value, which is based on quoted market prices. Unrealized gains and losses are reported in accumulated other comprehensive items in shareholders’ equity (deficit). Amortization and accretion of premiums and discounts are recorded in interest income (expense). Realized gains or losses on debt securities are included in other income (expense). If any adjustments to fair value reflect a decline in value of the investment, the Company considers all available evidence to evaluate the extent to which the decline is other than temporary and, if so, marks the investment to market on the Company’s statement of operations and comprehensive income (loss). |
Restricted Cash | Restricted Cash As of December 31, 2021 and 2020 , restricted cash consisted of nil and $ 0.2 million, respectively, used to secure a letter of credit denominated in a foreign currency for the benefit of the landlord in connection with one of the Company’s lease agreements. |
Concentrations of Credit Risk and Off-Balance Sheet Risk | Concentrations of Credit Risk and Off-Balance Sheet Risk Financial instruments that potentially expose the Company to concentrations of credit risk consist primarily of cash and cash equivalents. The Company maintains deposits in accredited financial institutions which may periodically exceed insured limits. The Company deposits its cash in financial institutions that it believes have high credit quality and has not experienced any losses on such accounts and does not believe it is exposed to any unusual credit risk beyond the normal credit risk associated with commercial banking relationships. The Company’s exposure to foreign exchange risk is primarily related to fluctuations between the Canadian dollar and the U.S. dollar. There are balances in Canadian dollars which are subject to foreign currency fluctuations relating to the impact of translating to U.S. dollars for financial statement presentation. As of December 31, 2021 and 2020 , the Company had no significant off-balance sheet risk, such as foreign exchange contracts, option contracts or other foreign hedging arrangements. |
Comprehensive Loss | Comprehensive Loss Comprehensive loss includes net loss as well as other changes in shareholders’ equity (deficit) that result from transactions and economic events other than those with shareholders. For each of the years ended December 31, 2021, 2020 and 2019 , comprehensive loss was equal to net loss. |
Fair Value Measurements | Fair Value Measurements Certain assets and liabilities of the Company are carried at fair value under U.S. GAAP. Fair value is defined as the exchange price that would be received for an asset or paid to transfer a liability (an exit price) in the principal or most advantageous market for the asset or liability in an orderly transaction between market participants on the measurement date. Valuation techniques used to measure fair value must maximize the use of observable inputs and minimize the use of unobservable inputs. Financial assets and liabilities carried at fair value are to be classified and disclosed in one of the following three levels of the fair value hierarchy, of which the first two are considered observable and the last is considered unobservable: Level 1 – Quoted prices in active markets for identical assets or liabilities. Level 2 – Observable inputs (other than Level 1 quoted prices), such as quoted prices in active markets for similar assets or liabilities, quoted prices in markets that are not active for identical or similar assets or liabilities, or other inputs that are observable or can be corroborated by observable market data. Level 3 – Unobservable inputs that are supported by little or no market activity that are significant to determining the fair value of the assets or liabilities, including pricing models, discounted cash flow methodologies and similar techniques. To the extent that the valuation is based on models or inputs that are less observable or unobservable in the market, the determination of fair value requires more judgment. Accordingly, the degree of judgment exercised by the Company in determining fair value is greatest for instruments categorized in Level 3. Financial assets and liabilities are classified in their entirety based on the lowest level of input that is significant to the fair value measurement. An entity may choose to measure financial instruments and certain other items at fair value at specified election dates. Subsequent unrealized gains and losses on items for which the fair value option has been elected will be reported in earnings. The estimated fair values of the Company’s cash and cash equivalents, restricted cash, other assets, accounts payable and accrued expenses and other current liabilities approximate their carrying values. The Company’s marketable securities are carried at fair value, determined according to Level 1 inputs in the fair value hierarchy described above. |
Property and Equipment, Net | Property and Equipment, Net Property and equipment is stated at historical cost, net of accumulated depreciation. Depreciation is calculated using the straight-line method over the estimated useful lives of the assets, which are as follows: Asset Category Estimated Useful Lives Computer equipment 3 years Office equipment 5 years Laboratory equipment 5 years Leasehold improvements the shorter of the lease term and the useful life When assets are retired or disposed of, the assets and related accumulated depreciation are derecognized from the accounts, and any resulting gain or loss is included in the determination of net loss. Expenditures for maintenance and repairs are recorded to expense as incurred. |
Impairment of Long-Lived Assets | Impairment of Long-Lived Assets The Company evaluates its finite-lived intangible assets for impairment whenever events or changes in circumstances indicate that the carrying value of assets may not be recoverable. Recoverability of these assets is measured by comparing their carrying value to the future net undiscounted cash flows the assets are expected to generate over their remaining economic life. If such assets are considered impaired, the impairment to be recognized is measured by the amount by which the carrying value of the assets exceeds their fair value. Indefinite-lived intangible assets are tested for impairment annually, or more frequently if indicators of impairment are present. To date, no such impairment losses have been recorded. |
Leases | Leases At the inception of an arrangement, the Company determines whether the arrangement is or contains a lease based on the unique facts and circumstances present in the arrangement. Leases with a term greater than one year are recognized on the consolidated balance sheet as a right-of-use asset and current and non-current lease liabilities, as applicable. Operating lease liabilities and their corresponding right-of-use assets are initially recorded based on the present value of lease payments over the expected remaining lease term. Certain adjustments to the right-of-use asset may be required for items such as incentives received. The interest rate implicit in lease contracts is typically not readily determinable. As a result, the Company utilizes its incremental borrowing rate to discount lease payments, which reflects the fixed rate at which the Company could borrow on a collateralized basis the amount of the lease payments in the same currency, for a similar term, in a similar economic environment. Prospectively, the Company will adjust the right-of-use assets for straight-line rent expense or any incentives received and remeasure the lease liability at the net present value using the same incremental borrowing rate that was in effect as of the lease commencement or transition date. The Company typically only includes an initial lease term in its assessment of a lease arrangement. Options to renew a lease are not included in the Company’s assessment unless there is reasonable certainty that the Company will renew. Assumptions made by the Company at the commencement date are re-evaluated upon occurrence of certain events, including a lease modification. A lease modification results in a separate contract when the modification grants the lessee an additional right of use not included in the original lease and when lease payments increase commensurate with the standalone price for the additional right of use. When a lease modification results in a separate contract, it is accounted for in the same manner as a new lease. In accordance with ASC 842, components of a lease should be split into three categories: lease components, non-lease components and non-components. The fixed and in-substance fixed contract consideration (including any consideration related to non-components) must be allocated based on the respective relative fair values to the lease components and non-lease components. Entities may elect not to separate lease and non-lease components. The Company has elected to account for lease and non-lease components together as a single lease component for all underlying assets and allocate all of the contract consideration to the lease component only. |
Revenue Recognition | Revenue Recognition The Company recognizes revenue in accordance with ASC 606, Revenue from Contracts with Customers (“ASC 606”). This standard applies to all contracts with customers, except for contracts that are within the scope of other standards, such as leases, insurance, collaboration arrangements and financial instruments. Under ASC 606, an entity recognizes revenue when its customer obtains control of promised goods or services, in an amount that reflects the consideration which the entity expects to receive in exchange for those goods or services. To determine revenue recognition for arrangements that an entity determines are within the scope of ASC 606, the entity performs the following five steps: (i) identify the contract(s) with a customer; (ii) identify the performance obligations in the contract; (iii) determine the transaction price; (iv) allocate the transaction price to the performance obligations in the contract; and (v) recognize revenue when (or as) the entity satisfies a performance obligation. The Company only applies the five-step model to contracts when it is probable that the entity will collect the consideration it is entitled to in exchange for the goods or services it transfers to the customer. At contract inception, once the contract is determined to be within the scope of ASC 606, the Company assesses the goods or services promised within each contract and determines those that are performance obligations and assesses whether each promised good or service is distinct. The Company then recognizes as revenue the amount of the transaction price that is allocated to the respective performance obligation when (or as) the performance obligation is satisfied. The Company enters into collaboration and license agreements, which are within the scope of ASC 606, to discover, develop, manufacture, and commercialize product candidates. The terms of these agreements typically contain multiple promises or obligations, which may include: (i) licenses to compounds directed to specific targets (referred to as “exclusive licenses”) and (ii) research and development activities to be performed on behalf of the collaboration partner related to the licensed targets. Payments to the Company under these agreements may include non-refundable license fees, customer option exercise fees, payments for research activities, reimbursement of certain costs, payments based upon the achievement of certain milestones and royalties on any resulting net product sales. The Company first evaluates license and/or collaboration arrangements to determine whether the arrangement (or part of the arrangement) represents a collaborative arrangement pursuant to ASC 808, Collaborative Arrangements (“ASC 808”), based on the risks and rewards and activities of the parties pursuant to the contractual arrangement. The Company accounts for collaborative arrangements (or elements within the contract that are deemed part of a collaborative arrangement), which represent a collaborative relationship and not a customer relationship, outside the scope of ASC 606. The Company’s collaborations primarily represent revenue arrangements. For the arrangements or arrangement components that are subject to revenue accounting guidance, in determining the appropriate amount of revenue to be recognized as it fulfills its obligations under each of its agreements, the Company applies the five-step model. As part of the accounting for these arrangements, the Company must use significant judgment to determine: a) the number of performance obligations based on the determination under step (ii) above and whether those performance obligations are distinct from other performance obligations in the contract; b) the transaction price under step (iii) above; and c) the stand-alone selling price for each performance obligation identified in the contract for the allocation of transaction price in step (iv) above. The Company uses judgment to determine whether milestones or other variable consideration, except for sales-based royalties, should be included in the transaction price as described further below. The transaction price is allocated to each performance obligation on a relative stand-alone selling price basis, for which the Company recognizes revenue as or when the performance obligations under the contract are satisfied. In determining the stand-alone selling price of a license to the Company’s proprietary technology or a material right provided by a customer option, the Company considers market conditions as well as entity-specific factors, including those factors contemplated in negotiating the agreements as well as internally developed estimates that include assumptions related to the market opportunity, estimated development costs, probability of success and the time needed to commercialize a product candidate pursuant to the license. In validating its estimated stand-alone selling price, the Company evaluates whether changes in the key assumptions used to determine its estimated stand-alone selling price will have a significant effect on the allocation of arrangement consideration between performance obligations. Amounts received prior to revenue recognition are recorded as deferred revenue. Amounts expected to be recognized as revenue within one year following the balance sheet date are classified as current portion of deferred revenue in the accompanying consolidated balance sheets. Amounts not expected to be recognized as revenue within one year following the balance sheet date are classified as deferred revenue, net of current portion. Amounts recognized as revenue, but not yet received or invoiced are generally recognized as contract assets. Exclusive Licenses – If the license to the Company’s intellectual property is determined to be distinct from the other promises or performance obligations identified in the arrangement, which generally include research and development services, the Company recognizes revenue from non-refundable, upfront fees allocated to the license when the license is transferred to the customer and the customer is able to use and benefit from the license. In assessing whether a license is distinct from the other promises, the Company considers relevant facts and circumstances of each arrangement, including the research and development capabilities of the collaboration partner and the availability of the associated expertise in the general marketplace. In addition, the Company considers whether the collaboration partner can benefit from the license for its intended purpose without the receipt of the remaining promises, whether the value of the license is dependent on the unsatisfied promises, whether there are other vendors that could provide the remaining promises and whether it is separately identifiable from the remaining promises. For licenses that are combined with other promises, the Company utilizes judgment to assess the nature of the combined performance obligation and whether the license is the predominant promise within the combined performance obligation to determine whether the combined performance obligation is satisfied over time or at a point in time and, if over time, the appropriate method of measuring progress for purposes of recognizing revenue. If the license is the predominant promise, and it is determined that the license represents functional intellectual property (“IP”), revenue is recognized at the point in time when control of the license is transferred. If it is determined that the license does not represent functional IP, revenue is recognized over time using an appropriate method of measuring progress. Research and Development Services – The obligations under the Company’s collaboration and license agreements generally include research and development services to be performed by the Company to benefit the collaboration partner. For performance obligations that include research and development services, the Company generally recognizes revenue allocated to such performance obligations based on an appropriate measure of progress. The Company utilizes judgment to determine the appropriate method of measuring progress for purposes of recognizing revenue, which is generally an input measure such as costs incurred. The Company evaluates the measure of progress each reporting period and, if necessary, adjusts the measure of performance and related revenue recognition. The measure of progress, and thereby periods of which revenue should be recognized, are subject to estimates by management and may change over the course of the contract. Reimbursements from the partner that are the result of a collaborative relationship with the partner, instead of a customer relationship, such as co-development activities, are recorded as a reduction to research and development expense. Customer Options – The Company’s arrangements may provide a collaborator with the right to acquire additional goods or services in the future. Under these agreements, fees may be due to the Company (i) at the inception of the arrangement as an upfront fee or payment or (ii) upon the exercise of the customer option. If an arrangement is determined to contain customer options that allow the customer to acquire additional goods or services, the goods and services underlying the customer options are not considered to be performance obligations at the outset of the arrangement, as they are contingent upon option exercise. The Company evaluates the customer options for material rights, or options to acquire additional goods or services for free or at a discount. If the customer options are determined to represent a material right, the material right is recognized as a separate performance obligation at the inception of the arrangement. The Company allocates the transaction price to material rights based on the relative stand-alone selling price, which is determined based on the identified discount and the probability that the customer will exercise the option. Amounts allocated to a material right are not recognized as revenue until, at the earliest, the option is exercised or expires. Milestone Payments – At the inception of each arrangement that includes development milestone payments, the Company evaluates whether the milestones are considered probable of being achieved and estimates the amount to be included in the transaction price using the most likely amount method. If it is probable that a significant revenue reversal would not occur, the associated milestone value is included in the transaction price. Milestone payments that are not within the control of the Company or the licensee, such as regulatory approvals, are not considered probable of being achieved until those approvals are received. The Company evaluates factors such as the scientific, clinical, regulatory, commercial, and other risks that must be overcome to achieve the particular milestone in making this assessment. There is considerable judgment involved in determining whether it is probable that a significant revenue reversal would not occur. At the end of each subsequent reporting period, the Company reevaluates the probability of achievement of all milestones subject to constraint and, if necessary, adjusts its estimate of the overall transaction price. Any such adjustments are recorded on a cumulative catch-up basis, which would affect revenues and earnings in the period of adjustment. If a milestone or other variable consideration relates specifically to the Company’s efforts to satisfy a single performance obligation or to a specific outcome from satisfying the performance obligation, the Company generally allocates the milestone amount entirely to that performance obligation once it is probable that a significant revenue reversal would not occur. Royalties – For arrangements that include sales-based royalties, including milestone payments based on a level of sales, and the license is deemed to be the predominant item to which the royalties relate, the Company recognizes revenue at the later of (i) when the related sales occur or (ii) when the performance obligation to which some or all of the royalty has been allocated has been satisfied (or partially satisfied). To date, the Company has not recognized any royalty revenue resulting from any of its licensing arrangements. For a complete discussion of accounting for collaboration revenues, s ee Note 13. |
Research and Development Expenses | Research and Development Expenses Research and development costs are expensed as incurred. The Company’s research and development expenses consist primarily of costs incurred in performing research and development activities, including salaries and other compensation, share-based compensation, fees paid to external service providers, laboratory supplies and costs for facilities and equipment, partially offset by fully refundable research and development tax credits. Non-refundable prepayments for goods or services that will be used or rendered for future research and development activities are deferred and capitalized. Such amounts are expensed as the goods are delivered or the services are performed, or until it is no longer expected that the goods will be delivered, or the services rendered. |
Accrued and Prepaid Research and Development Expenses | Accrued and Prepaid Research and Development Expenses The Company has entered into various research and development contracts. The payments to these agreements are recorded as research and development expenses as incurred. The Company records accrued liabilities and prepaid expenses for estimated ongoing research costs. When evaluating the adequacy of the accrued liabilities and prepaid expenses, the Company analyzes progress of the studies, including the phase or completion of events, invoices received and contracted costs. Significant judgements and estimates are made in determining the accrued and prepaid balances at the end of any reporting period. Actual results could differ from the Company’s estimates. |
Share-Based Compensation | Share-Based Compensation The Company accounts for all share-based awards granted to employees and non-employees as share-based compensation expense at fair value. Since the Company’s IPO in June 2020, the fair value of the underlying common shares is based on the trading price of the Company’s common shares. Prior to the Company’s IPO, the Company previously engaged an independent valuation firm to determine the fair value of the underlying common shares. The independent valuation firm used valuation techniques and methods that comply with guidance provided by the American Institute of Certified Public Accountants in its Accounting & Valuation Guide. Each valuation methodology included estimates and assumptions that required the Company’s judgment. These estimates and assumptions included a number of objective and subjective factors in determining the value of the Company’s common shares at each grant date, including: (1) prices paid for the Company’s convertible preferred shares, which the Company has sold to outside investors in arm’s-length transactions, and the rights, preferences and privileges of the Company’s convertible preferred shares and common shares; (2) valuations performed by an independent valuation specialist; (3) the Company’s stage of development; (4) the fact that grants of share-based awards involved illiquid securities in a private company; and (5) the likelihood of achieving a liquidity event for the common shares underlying the share-based awards, such as an initial public offering or sale of the Company, given prevailing market conditions. The measurement date for employee and non-employee awards is the date of grant, and share-based compensation costs are recognized over the employees’ requisite service period, which is the vesting period, on a straight-line basis. The fair value of each stock option grant or purchases under our 2020 Employee Share Purchase Plan (“ESPP”) is estimated on the date of grant using the Black-Scholes option-pricing model, which requires inputs based on certain subjective assumptions, including the expected share price volatility, the expected term of the option, the risk-free interest rate for a period that approximates the expected term of the option and the Company’s expected dividend yield. As there was no public market for its common shares prior to its IPO, the Company determined the volatility for stock option awards granted based on an analysis of reported data for a group of guideline companies that issued options with substantially similar terms. The expected volatility has been determined using a weighted-average of the historical volatility measures of this group of guideline companies. The Company expects to continue to do so until such time as it has adequate historical data regarding the volatility of its own traded share price. For purchases under our ESPP, the historical volatility is used when developing an estimate of expected volatility. The expected term of the Company’s stock options granted to employees and non-employees has been determined utilizing the “simplified” method for awards that qualify as “plain-vanilla” options. In connection with the adoption of ASU No. 2018-07, Compensation—Stock Compensation (“ASU No. 2018-07”), the Company calculated the expected term of non-employee awards using the midpoint between the vesting date and the contractual term, which is consistent with the method used for employee awards. For purchases under our ESPP, the expected term is based on the length of the offering period. The risk-free interest rate is determined by reference to the U.S. Treasury yield curve in effect at the time of grant of the award, for time periods approximately equal to the expected term of the award. The Company has not paid, and does not anticipate paying, cash dividends on its common shares; therefore, the expected dividend yield is assumed to be zero . Share-based compensation is classified in the accompanying consolidated statements of operations and comprehensive loss based on the function to which the related services are provided. Forfeitures are accounted for as they occur. Any consideration paid by employees on exercising stock options or the purchases under our ESPP and the corresponding portion previously credited to additional paid-in capital are credited to share capital. |
Share Issuance Costs | Share Issuance Costs Share issuance costs applicable to the issuance of equity instruments are recorded as a reduction of the financing equity proceeds. |
Net Loss per Share | Net Loss per Share Basic net loss per share attributable to common shareholders is computed by dividing the net loss attributable to common shareholders by the weighted-average number of common shares outstanding during the reporting period, without consideration for potentially dilutive securities. Diluted net loss per share is computed by dividing the net loss attributable to common shareholders by the weighted-average number of common shares and potentially dilutive securities outstanding during the period determined using the treasury-stock and if-converted methods. For purposes of the diluted net loss per share calculation, convertible preferred shares and stock options considered to be potentially dilutive securities were excluded from the calculation of diluted net loss per share because their effect would be anti-dilutive and therefore, basic and diluted net loss per share were the same for all reporting periods presented. |
Income Taxes | Income Taxes The Company recognizes deferred tax assets and liabilities for the expected future tax consequences of events that have been recognized in the Company’s consolidated financial statements. Under this method, deferred tax assets and liabilities are determined based on differences between the consolidated financial statement carrying amounts and the tax bases of the assets and liabilities using the enacted tax rates in effect in the years in which the differences are expected to reverse. A valuation allowance against deferred tax assets is recorded if, based on the weight of the available evidence, it is more likely than not that some or all of the deferred tax assets will not be realized. The Company accounts for uncertainty in income taxes recognized in the financial statements by applying a two-step process to determine the amount of tax benefit to be recognized. First, the tax position must be evaluated to determine the likelihood that it will be sustained upon external examination by the taxing authorities. If the tax position is deemed more-likely-than-not to be sustained, the tax position is then assessed to determine the amount of benefit to recognize in the financial statements. The amount of benefit that may be recognized is the largest amount that has a greater than 50% likelihood of being realized upon ultimate settlement. The provision for income taxes includes the effects of any resulting tax reserves, or unrecognized tax benefits, that are considered appropriate as well as the related net interest and penalties. |
Research and Development Tax Credits | Research and Development Tax Credits The Company recognizes the benefit of refundable Canadian research and development tax credits as a reduction of research and development costs when there is reasonable assurance that the amount claimed will be recovered. |
Recently Adopted Accounting Pronouncements | Recently Adopted Accounting Pronouncements In December 2019, the FASB issued ASU No. 2019-12, Income Taxes - Simplifying the Accounting for Income Taxes (“ASU No. 2019-12”). ASU No. 2019-12 eliminates certain exceptions related to the approach for intra-period tax allocation, the methodology for calculating income taxes in an interim period and the recognition of deferred tax liabilities for outside basis differences. The new guidance also simplifies aspects of the accounting for franchise taxes and enacted changes in tax laws or rates and clarifies the accounting for transactions that result in a step-up in the tax basis of goodwill. For public entities, ASU No. 2019-12 was effective for annual periods beginning after December 15, 2020, including interim periods within. Adoption of the standard requires certain changes to be made prospectively, with some changes to be made retrospectively. The adoption of ASU No. 2019-12 did not have a material impact on the Company’s consolidated financial statements. |
Recently Issued Accounting Pronouncements | Recently Issued Accounting Pronouncements There were no new accounting pronouncements issued which could have a significant effect on the Company's consolidated financial statements. |
Summary of Significant Accoun_3
Summary of Significant Accounting Policies (Tables) | 12 Months Ended |
Dec. 31, 2021 | |
Accounting Policies [Abstract] | |
Schedule of Estimated Useful Lives of Property and Equipment | Property and equipment is stated at historical cost, net of accumulated depreciation. Depreciation is calculated using the straight-line method over the estimated useful lives of the assets, which are as follows: Asset Category Estimated Useful Lives Computer equipment 3 years Office equipment 5 years Laboratory equipment 5 years Leasehold improvements the shorter of the lease term and the useful life |
Fair Value Measurements (Tables
Fair Value Measurements (Tables) | 12 Months Ended |
Dec. 31, 2021 | |
Fair Value Disclosures [Abstract] | |
Schedule of Financial Assets and Liabilities Measured at Fair Value on a Recurring Basis | The following table presents information about the Company’s financial assets and liabilities measured at fair value on a recurring basis and indicates the level of the fair value hierarchy utilized to determine such fair values: Description Financial Assets Quoted Significant Significant (in thousands) As at December 31, 2021 Assets Cash equivalents Money market funds $ 2,535 $ 2,535 $ — $ — Marketable securities U.S. Treasury notes 7,439 7,439 — — Total financial assets $ 9,974 $ 9,974 $ — $ — As at December 31, 2020 Assets Cash equivalents Money market funds $ 2,455 $ 2,455 $ — $ — Marketable securities U.S. Treasury notes 7,526 7,526 — — Total financial assets $ 9,981 $ 9,981 $ — $ — |
Cash and Cash Equivalents and_2
Cash and Cash Equivalents and Marketable Securities (Tables) | 12 Months Ended |
Dec. 31, 2021 | |
Investments Debt And Equity Securities [Abstract] | |
Summary of Cash and Cash Equivalents and Marketable Securities | As of December 31, 2021 and 2020, cash and cash equivalents and marketable securities were comprised of the following: Amortized Cost Unrealized Gains Unrealized Losses Fair Value (in thousands) As at December 31, 2021 Money market funds included in cash and $ 2,535 $ — $ — $ 2,535 Marketable securities: U.S. Treasury notes 7,439 — — 7,439 Total $ 9,974 $ — $ — $ 9,974 As at December 31, 2020 Money market funds included in cash and $ 2,455 $ — $ — $ 2,455 Marketable securities: U.S. Treasury notes 7,526 — — 7,526 Total $ 9,981 $ — $ — $ 9,981 |
Property and Equipment, Net (Ta
Property and Equipment, Net (Tables) | 12 Months Ended |
Dec. 31, 2021 | |
Property Plant And Equipment [Abstract] | |
Schedule of Property and Equipment, Net | Property and equipment, net as of December 31, 2021 and 2020 consisted of the following: December 31, 2021 2020 (in thousands) Computer equipment $ 469 $ 301 Office equipment 509 216 Laboratory equipment 5,536 4,718 Leasehold improvements 2,465 706 Total 8,979 5,941 Less: Accumulated depreciation ( 3,375 ) ( 1,993 ) Property and equipment, net $ 5,604 $ 3,948 |
Schedule of Depreciation Expense Recognized | Depreciation expense recognized was allocated as follows: Year Ended December 31, 2021 2020 2019 (in thousands) Research and development $ 1,325 $ 786 $ 540 General and administration 146 111 65 Depreciation expense $ 1,471 $ 897 $ 605 |
Accrued Expenses and Other Cu_2
Accrued Expenses and Other Current Liabilities (Tables) | 12 Months Ended |
Dec. 31, 2021 | |
Payables And Accruals [Abstract] | |
Schedule of Accrued Expenses and Other Current Liabilities | Accrued expenses and other current liabilities as of December 31, 2021 and 2020 consisted of the following: December 31, 2021 2020 (in thousands) Accrued compensation and benefits $ 4,867 $ 2,771 Accrued research and development expense 11,272 2,584 Accrued professional services 387 436 Accrued property and equipment purchases 1,719 126 Other 377 58 Total accrued expenses and other current liabilities $ 18,622 $ 5,975 |
Leases (Tables)
Leases (Tables) | 12 Months Ended |
Dec. 31, 2021 | |
Leases [Abstract] | |
Summary of Lease Costs | The following tables contains a summary of the lease costs recognized under ASC 842 and other information pertaining to the Company’s operating leases for the years ended December 31, 2021, 2020 and 2019: December 31, 2021 2020 2019 (in thousands) Operating Leases Lease Cost Operating lease cost $ 2,101 $ 999 $ 411 Short-term lease cost 25 51 12 Variable lease cost 163 161 248 Total lease cost $ 2,289 $ 1,211 $ 671 |
Summary of Other Operating Lease Information | December 31, 2021 2020 2019 (in thousands, except as specified otherwise) Other Operating Lease Information Operating cash flows for operating leases $ 1,240 $ 802 $ 426 Right-of-use assets obtained in exchange for lease obligations $ 4,690 $ 4,538 $ 1,074 Weighted-average remaining lease term (in years) 3.35 4.50 1.79 Weighted-average discount rate 4.0 % 5.1 % 7.6 % |
Summary of Future Minimum Lease Payments under Operating Leases | Future minimum lease payments under the Company’s operating leases as of December 31, 2021 were as follows: December 31, (in thousands) Maturity of Lease Liabilities 2022 $ 1,982 2023 2,446 2024 2,492 2025 929 Total lease payments $ 7,849 Less: interest ( 536 ) Total lease liabilities $ 7,313 |
Share-Based Compensation (Table
Share-Based Compensation (Tables) | 12 Months Ended |
Dec. 31, 2021 | |
Disclosure Of Compensation Related Costs Sharebased Payments [Abstract] | |
Schedule of Assumptions used to Determine Grant Date Fair Value under ESPP Offering | The assumptions that the Company used in the Black Scholes option-pricing model to determine the grant date fair value under the ESPP offering were as follows: Year Ended December 31, 2021 Risk-free interest rate 0.05 % Expected term (in years) 0.50 Expected volatility 61.91 % Expected dividend yield 0.00 % |
Schedule of Fair Value of Stock Options Determined on Grant Date Using Black Scholes Option-Pricing Model | The assumptions that the Company used in the Black Scholes option-pricing model to determine the grant date fair value of stock options granted to employees and non-employees were as follows, presented on a weighted-average basis: Year Ended December 31, 2021 2020 2019 Risk-free interest rate 0.80 % 0.45 % 1.94 % Expected term (in years) 6.00 6.07 6.10 Expected volatility 75.99 % 72.26 % 71.41 % Expected dividend yield 0.00 % 0.00 % 0.00 % |
Schedule of Share Option Activity | The following table summarizes the Company’s share option activity: 2021 Number of Weighted Weighted Intrinsic value (in thousands) Outstanding, 4,132,123 $ 6.39 Granted 1,645,416 $ 34.14 Exercised ( 333,996 ) $ 2.96 Forfeited ( 120,952 ) $ 25.26 Outstanding, 5,322,591 $ 14.76 8.15 $ 55,722 Options 2,090,060 $ 6.28 7.47 $ 32,409 Options unvested, 3,232,531 $ 20.24 8.59 $ 23,313 |
Schedule of Share-based Compensation Expense | Share-based compensation expense for all awards was allocated as follows: Year Ended December 31, 2021 2020 2019 (in thousands) Research and development $ 5,681 $ 890 $ 250 General and administrative 7,148 1,647 261 Total share-based compensation expense $ 12,829 $ 2,537 $ 511 Share-based compensation expense by type of award was as follows: Year Ended December 31, 2021 2020 2019 (in thousands) Stock options $ 12,632 $ 2,537 $ 511 ESPP 197 - - Total share-based compensation expense $ 12,829 $ 2,537 $ 511 |
Collaborations (Tables)
Collaborations (Tables) | 12 Months Ended |
Dec. 31, 2021 | |
Organization Consolidation And Presentation Of Financial Statements [Abstract] | |
Schedule of Transaction Price Performance Obligations | Based on the relative stand-alone selling price, the allocation of the transaction price to the separate performance obligations was as follows: Performance obligation Transaction price (in thousands) Research activities $ 6,405 Options to license druggable targets 31,148 Options to license undruggable targets 12,447 Total transaction price $ 50,000 |
Income Taxes (Tables)
Income Taxes (Tables) | 12 Months Ended |
Dec. 31, 2021 | |
Income Tax Disclosure [Abstract] | |
Summary of Loss Before Provision for Income Taxes | Loss before the provision for income taxes consisted of the following: Year Ended December 31, 2021 2020 2019 (in thousands) Canada $ ( 110,433 ) $ ( 55,446 ) $ ( 27,355 ) Foreign $ 1,847 $ 704 $ 334 Loss before provision for income taxes $ ( 108,586 ) $ ( 54,742 ) $ ( 27,021 ) |
Summary of provision for income taxes | The components of the provision for income taxes are as follows: Year Ended December 31, 2021 2020 2019 (in thousands) Current income tax provision - foreign $ 530 $ ( 45 ) $ 327 Deferred income tax benefit - foreign ( 2,208 ) ( 1,280 ) ( 132 ) Total provision for income taxes $ ( 1,678 ) $ ( 1,325 ) $ 195 |
Summary of Reconciliation of Provision for Income Taxes | A reconciliation between tax expense and the product of accounting income multiplied by the statutory income tax rate is as follows: Year Ended December 31, 2021 2020 2019 (in thousands) Loss before income taxes $ ( 108,586 ) $ ( 54,742 ) $ ( 27,021 ) Income tax at statutory rate 26.5 % 26.5 % 26.5 % Computed income tax recovery ( 28,775 ) ( 14,507 ) ( 7,160 ) Effect on income tax resulting from: Federal investment tax credit ( 4,093 ) ( 2,347 ) ( 985 ) Accounting charges not deductible for tax purposes 1,078 1,088 143 Equity compensation 2,220 ( 742 ) 134 Other 644 ( 306 ) ( 16 ) Change in valuation allowance 27,248 15,489 8,079 Tax (benefit) expense $ ( 1,678 ) $ ( 1,325 ) $ 195 |
Summary of Losses Expire | The Company has not recognized the tax benefit of these losses. These losses expire as follows: (in thousands) 2041 $ 94,231 2040 — 2039 11,394 2038 7,052 2037 883 Total $ 113,560 |
Summary of Investment Tax Credits Expire | The Company has not recognized the tax benefits related to the non-refundable investment tax credits. The investment tax credits (in thousands) 2041 $ 2,217 2040 1,702 2039 1,362 2038 776 2037 455 2036 24 Total $ 6,536 |
Summary of Deferred Tax Assets | The Company’s deferred tax assets as of December 31, 2021 and 2020 consisted of the following: 2021 2020 (in thousands) Net operating loss carryforwards $ 30,093 $ 5,087 Net research and development expenditures 10,656 7,478 Share issuance costs 3,538 4,506 Net federal investment tax credits 4,805 3,181 U.S. research and development tax credits 1,775 961 Tax basis of property and equipment in excess of carrying values — ( 86 ) Operating lease right-of-use assets ( 1,995 ) ( 1,240 ) Operating lease liability 1,950 1,063 Accrued expense and other liabilities 760 345 Deferred revenue 13,656 15,372 Share-based compensation 988 103 Total deferred tax assets 66,226 36,770 Valuation allowance ( 62,606 ) ( 35,358 ) Net deferred tax assets $ 3,620 $ 1,412 |
Net Loss per Share (Tables)
Net Loss per Share (Tables) | 12 Months Ended |
Dec. 31, 2021 | |
Earnings Per Share [Abstract] | |
Summary of Computation of Basic and Diluted Net Loss Per Share Attributable To Common Shareholders | The following table summarizes the computation of basic and diluted net loss per share attributable to common shareholders of the Company: Year Ended December 31, 2021 2020 2019 (in thousands, except share and per share data) Numerator: Net loss attributable to common shareholders $ ( 106,908 ) $ ( 53,417 ) $ ( 27,216 ) Net loss attributable to common shareholders—basic and diluted $ ( 106,908 ) $ ( 53,417 ) $ ( 27,216 ) Denominator: Weighted-average number of common shares outstanding— 37,818,115 20,045,602 1,528,374 Net loss per share attributable to common shareholders— $ ( 2.83 ) $ ( 2.66 ) $ ( 17.81 ) |
Computation of Diluted Net Loss Per Share in Attributable to Common Shareholders Indicate to Anti Diluted Effect | The Company excluded the following potential common shares, presented based on amounts outstanding at each period end, from the computation of diluted net loss per share attributable to common shareholders for the periods indicated because including them would have had an anti-dilutive effect: Year Ended December 31, 2021 2020 2019 Series A preferred shares — — 11,090,135 Series B preferred shares — — 10,468,258 Options to purchase common shares 5,322,591 4,132,123 3,505,119 |
Commitments and Contingencies (
Commitments and Contingencies (Tables) | 12 Months Ended |
Dec. 31, 2021 | |
Commitments And Contingencies Disclosure [Abstract] | |
Schedule of Commitments to Settle Contractual Obligations | The following table summarizes the Company’s commitments to settle contractual obligations at December 31, 2021, other than leases which are recognized as operating lease liabilities in the consolidated balance sheet. Year Ending December 31, (in thousands) 2022 $ 2,449 2023 2,333 2024 2,349 2025 33 2026 49 Following years 32 Total $ 7,245 |
Currency Risk (Tables)
Currency Risk (Tables) | 12 Months Ended |
Dec. 31, 2021 | |
Foreign Currency Risk [Abstract] | |
Schedule of Financial Position Exposure | The Company is exposed to currency risk through its cash, research and development tax credits receivable, other receivables, accounts payable, accrued expenses and other current liabilities, as well as right-of-use lease liabilities denominated in Canadian dollars as follows: December 31, 2021 2020 (in thousands) Cash $ 3,583 $ 1,715 Restricted cash — 270 Research and development tax credits receivable 3,261 2,559 Other receivables 745 5,228 Accounts payable ( 665 ) ( 1,322 ) Accrued expenses and other current liabilities ( 2,116 ) ( 2,722 ) Lease liabilities ( 5,564 ) ( 4,847 ) Net financial position exposure $ ( 756 ) $ 881 |
Geographic Information (Tables)
Geographic Information (Tables) | 12 Months Ended |
Dec. 31, 2021 | |
Segment Reporting [Abstract] | |
Schedule of Property and Equipment, Net and Right-of-Use Assets by Location | The Company’s property and equipment, net by location was as follows: December 31, 2021 2020 (in thousands) Canada $ 3,675 $ 3,845 United States 1,929 103 Total property and equipment, net $ 5,604 $ 3,948 The Company’s right-of-use assets by location were as follows: December 31, 2021 2020 (in thousands) Canada $ 4,939 $ 4,483 United States 2,552 191 Total right-of-use assets, net $ 7,491 $ 4,674 |
Organization and Nature of Bu_2
Organization and Nature of Business - Additional Information (Details) $ / shares in Units, $ in Thousands | Nov. 01, 2021USD ($)$ / sharesshares | Jun. 23, 2020USD ($)$ / sharesshares | Jun. 12, 2020 | Jun. 30, 2020shares | Dec. 31, 2021USD ($)shares | Dec. 31, 2020USD ($)shares |
Organization and Nature of Business [Line Items] | ||||||
Entity incorporation, date of incorporation | Sep. 6, 2016 | |||||
Reverse stock split of share capital | 1-for-6.062 | |||||
Conversion ratio | 0.16496 | |||||
Net proceeds from IPO | $ | $ 232,043 | |||||
Accumulated deficit | $ | $ (210,266) | $ (103,358) | ||||
Net proceeds from issuance of common shares | $ | $ 94,288 | |||||
Follow On Offering | ||||||
Organization and Nature of Business [Line Items] | ||||||
Underwriting Commissions And Estimated Offering Expenses | $ | $ 800 | |||||
Common Shares | ||||||
Organization and Nature of Business [Line Items] | ||||||
Shares issued | shares | 3,299 | |||||
Gross proceeds from IPO | $ | $ 253,000 | |||||
Net proceeds from IPO | $ | $ 232,043 | |||||
Convertible preferred shares converted into common shares | shares | 21,558,393 | 21,558,393 | ||||
Shares issued upon exercise of warrants outstanding | shares | 750,000 | |||||
Shares issued, price per share | $ / shares | $ 20 | |||||
Common Shares | Initial Public Offering | ||||||
Organization and Nature of Business [Line Items] | ||||||
Shares issued | shares | 12,650,000 | 12,650,000 | ||||
Common Shares | Exercise of Underwriters Option | ||||||
Organization and Nature of Business [Line Items] | ||||||
Shares issued | shares | 1,650,000 | |||||
Common Shares | Follow On Offering | ||||||
Organization and Nature of Business [Line Items] | ||||||
Shares issued | shares | 4,600,000 | 4,600,000 | ||||
Shares issued, price per share | $ / shares | $ 22 | |||||
Net proceeds from issuance of common shares | $ | $ 94,300 | |||||
Maximum | Common Shares | Exercise of Underwriters Option | ||||||
Organization and Nature of Business [Line Items] | ||||||
Shares issued | shares | 600,000 | 1,650,000 |
Summary of Significant Accoun_4
Summary of Significant Accounting Policies - Additional Information (Details) - USD ($) | 12 Months Ended | |
Dec. 31, 2021 | Dec. 31, 2020 | |
Accounting Policies [Abstract] | ||
Restricted cash | $ 0 | $ 212,000 |
Significant off-balance sheet risk, description | As of December 31, 2021 and 2020, the Company had no significant off-balance sheet risk, such as foreign exchange contracts, option contracts or other foreign hedging arrangements. | |
Impairment of long-lived assets | $ 0 | |
Share based compensation, expected dividend yield assumed | $ 0 |
Summary of Significant Accoun_5
Summary of Significant Accounting Policies - Schedule of Estimated Useful Lives of Property and Equipment (Details) | 12 Months Ended |
Dec. 31, 2021 | |
Computer Equipment | |
Property Plant And Equipment [Line Items] | |
Estimated useful lives of assets | 3 years |
Office Equipment | |
Property Plant And Equipment [Line Items] | |
Estimated useful lives of assets | 5 years |
Laboratory Equipment | |
Property Plant And Equipment [Line Items] | |
Estimated useful lives of assets | 5 years |
Leasehold Improvements | |
Property Plant And Equipment [Line Items] | |
Estimated useful lives of assets, description | the shorter of the lease term and the useful life |
Fair Value Measurements - Sched
Fair Value Measurements - Schedule of Financial Assets and Liabilities Measured at Fair Value on a Recurring Basis (Details) - Fair Value Measurements, Recurring - USD ($) $ in Thousands | Dec. 31, 2021 | Dec. 31, 2020 |
Assets | ||
Total financial assets | $ 9,974 | $ 9,981 |
U.S. Treasury Notes | ||
Assets | ||
Total financial assets | 7,439 | 7,526 |
Quoted Prices in Active Markets for identical Assets (Level 1) | ||
Assets | ||
Total financial assets | 9,974 | 9,981 |
Quoted Prices in Active Markets for identical Assets (Level 1) | U.S. Treasury Notes | ||
Assets | ||
Total financial assets | 7,439 | 7,526 |
Money Market Funds | ||
Assets | ||
Total financial assets | 2,535 | 2,455 |
Money Market Funds | Quoted Prices in Active Markets for identical Assets (Level 1) | ||
Assets | ||
Total financial assets | $ 2,535 | $ 2,455 |
Fair Value Measurements - Addit
Fair Value Measurements - Additional Information (Details) - USD ($) | 12 Months Ended | |
Dec. 31, 2020 | Dec. 31, 2021 | |
Fair Value Disclosures [Abstract] | ||
Fair value, assets, transfers between levels | $ 0 | $ 0 |
Change in fair value of Series A Preferred Shares tranche obligation recorded in other expense | $ 1,350,000 |
Fair Value Measurements - Sch_2
Fair Value Measurements - Schedule of Aggregate Fair Value of Series A Preferred Share Tranche Obligation using Level 3 Inputs (Details) $ in Thousands | 12 Months Ended |
Dec. 31, 2020USD ($) | |
Fair Value Liabilities Measured On Recurring Basis Unobservable Input Reconciliation [Line Items] | |
Change in fair value | $ 1,350 |
Cash and Cash Equivalents and_3
Cash and Cash Equivalents and Marketable Securities - Summary of Cash and Cash Equivalents and Marketable Securities (Details) - USD ($) $ in Thousands | Dec. 31, 2021 | Dec. 31, 2020 | Dec. 31, 2019 |
Schedule Of Available For Sale Securities [Line Items] | |||
Amortized Cost | $ 9,974 | $ 9,981 | |
Unrealized Gains | 0 | 0 | $ 0 |
Unrealized Losses | 0 | 0 | $ 0 |
Fair Value | 9,974 | 9,981 | |
U.S. Treasury Notes | |||
Schedule Of Available For Sale Securities [Line Items] | |||
Amortized Cost | 7,439 | 7,526 | |
Unrealized Gains | 0 | ||
Unrealized Losses | 0 | ||
Fair Value | 7,439 | 7,526 | |
Money Market Funds | |||
Schedule Of Available For Sale Securities [Line Items] | |||
Amortized Cost | 2,535 | 2,455 | |
Unrealized Gains | 0 | ||
Unrealized Losses | 0 | ||
Fair Value | $ 2,535 | $ 2,455 |
Cash and Cash Equivalents and_4
Cash and Cash Equivalents and Marketable Securities - Additional Information (Details) - USD ($) $ in Thousands | Dec. 31, 2021 | Dec. 31, 2020 | Dec. 31, 2019 |
Investments Debt And Equity Securities [Abstract] | |||
Unrealized gains | $ 0 | $ 0 | $ 0 |
Unrealized losses | $ 0 | $ 0 | $ 0 |
Property and Equipment, Net - S
Property and Equipment, Net - Schedule of Property and Equipment, Net (Details) - USD ($) $ in Thousands | Dec. 31, 2021 | Dec. 31, 2020 |
Property Plant And Equipment [Line Items] | ||
Property and equipment, gross | $ 8,979 | $ 5,941 |
Less: Accumulated depreciation | (3,375) | (1,993) |
Property and equipment, net | 5,604 | 3,948 |
Computer Equipment | ||
Property Plant And Equipment [Line Items] | ||
Property and equipment, gross | 469 | 301 |
Office Equipment | ||
Property Plant And Equipment [Line Items] | ||
Property and equipment, gross | 509 | 216 |
Laboratory Equipment | ||
Property Plant And Equipment [Line Items] | ||
Property and equipment, gross | 5,536 | 4,718 |
Leasehold Improvements | ||
Property Plant And Equipment [Line Items] | ||
Property and equipment, gross | $ 2,465 | $ 706 |
Property and Equipment, Net -_2
Property and Equipment, Net - Schedule of Depreciation Expense Recognized (Details) - USD ($) $ in Thousands | 12 Months Ended | ||
Dec. 31, 2021 | Dec. 31, 2020 | Dec. 31, 2019 | |
Property Plant And Equipment [Line Items] | |||
Depreciation expense | $ 1,471 | $ 897 | $ 605 |
Research and Development Expense | |||
Property Plant And Equipment [Line Items] | |||
Depreciation expense | 1,325 | 786 | 540 |
General and Administrative Expense | |||
Property Plant And Equipment [Line Items] | |||
Depreciation expense | $ 146 | $ 111 | $ 65 |
Accrued Expenses and Other Cu_3
Accrued Expenses and Other Current Liabilities - Schedule of Accrued Expenses and Other Current Liabilities (Details) - USD ($) $ in Thousands | Dec. 31, 2021 | Dec. 31, 2020 |
Payables And Accruals [Abstract] | ||
Accrued compensation and benefits | $ 4,867 | $ 2,771 |
Accrued research and development expense | 11,272 | 2,584 |
Accrued professional services | 387 | 436 |
Accrued property and equipment purchases | 1,719 | 126 |
Other | 377 | 58 |
Total accrued expenses and other current liabilities | $ 18,622 | $ 5,975 |
License Agreements - Additional
License Agreements - Additional Information (Detail) - NYU Agreement - USD ($) | 1 Months Ended | 12 Months Ended | |
Jul. 31, 2018 | Dec. 31, 2021 | Dec. 31, 2020 | |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] | |||
License agreement milestone and royalty payments upon achievement of certain clinical and commercial milestones | $ 6,700,000 | $ 6,700,000 | |
Accrual of potential future milestone or royalty payment | $ 0 | $ 0 |
Leases - Additional Information
Leases - Additional Information (Details) $ in Millions | 1 Months Ended | 12 Months Ended | |||||
Jul. 31, 2021USD ($) | Nov. 30, 2017 | Jun. 30, 2017 | Dec. 31, 2021Lease | Dec. 31, 2020 | Dec. 31, 2019 | Nov. 30, 2019USD ($) | |
Lessee Lease Description [Line Items] | |||||||
Number of operating leases | Lease | 4 | ||||||
Lessee, operating lease, existence of option to terminate | false | ||||||
Implicit interest rate | 0.00% | 0.00% | 0.00% | ||||
Office and Laboratory Space | Montreal, Quebec | |||||||
Lessee Lease Description [Line Items] | |||||||
Operating lease, term of contract | 3 years | 4 years | 5 years | ||||
Operating lease, expiration month and year | 2020-10 | 2021-07 | |||||
Operating lease, existence of option to extend | true | true | |||||
Operating lease, option to extend, description | extended through October 2022 | extended through July 2025 | |||||
Prepaid rent | $ | $ 0.4 | $ 1 | |||||
Operating Lease, renewal term | 5 years | ||||||
Office Space | Cambridge, Massachusetts | |||||||
Lessee Lease Description [Line Items] | |||||||
Operating lease, term of contract | 3 years | ||||||
Operating lease, expiration month and year | 2024-12 | ||||||
Operating Lease, renewal term | 3 years |
Leases - Summary of Lease Costs
Leases - Summary of Lease Costs (Details) - USD ($) $ in Thousands | 12 Months Ended | ||
Dec. 31, 2021 | Dec. 31, 2020 | Dec. 31, 2019 | |
Lease Cost | |||
Operating lease cost | $ 2,101 | $ 999 | $ 411 |
Short-term lease cost | 25 | 51 | 12 |
Variable lease cost | 163 | 161 | 248 |
Total lease cost | $ 2,289 | $ 1,211 | $ 671 |
Leases - Summary of Other Opera
Leases - Summary of Other Operating Lease Information (Details) - USD ($) $ in Thousands | 12 Months Ended | ||
Dec. 31, 2021 | Dec. 31, 2020 | Dec. 31, 2019 | |
Leases [Abstract] | |||
Operating cash flows for operating leases | $ 1,240 | $ 802 | $ 426 |
Right-of-use assets obtained in exchange for lease obligations | $ 4,690 | $ 4,538 | $ 1,074 |
Weighted-average remaining lease term | 3 years 4 months 6 days | 4 years 6 months | 1 year 9 months 14 days |
Weighted-average discount rate | 4.00% | 5.10% | 7.60% |
Leases - Summary of Future Mini
Leases - Summary of Future Minimum Lease Payments under Operating Leases (Details) $ in Thousands | Dec. 31, 2021USD ($) |
Leases [Abstract] | |
2022 | $ 1,982 |
2023 | 2,446 |
2024 | 2,492 |
2025 | 929 |
Total lease payments | 7,849 |
Less: interest | (536) |
Total lease liabilities | $ 7,313 |
Convertible Preferred Shares -
Convertible Preferred Shares - Additional Information (Details) | Jun. 23, 2020shares | Jun. 30, 2020shares | Sep. 30, 2019USD ($)$ / sharesshares | Aug. 31, 2019 | Jan. 31, 2019USD ($)$ / sharesshares | Jun. 30, 2017USD ($)Tranche$ / sharesshares | Dec. 31, 2021USD ($) | Dec. 31, 2020USD ($)shares |
Temporary Equity [Line Items] | ||||||||
Conversion of convertible preferred shares into an equivalent number of common shares, Value | $ 135,997,000 | |||||||
Common Shares | ||||||||
Temporary Equity [Line Items] | ||||||||
Conversion of convertible preferred shares into an equivalent number of common shares, Value | $ 135,997,000 | |||||||
Conversion of convertible preferred shares into an equivalent number of common shares, Shares | shares | 21,558,393 | |||||||
Convertible preferred shares converted into common shares | shares | 21,558,393 | 21,558,393 | ||||||
Series A Preferred Shares | ||||||||
Temporary Equity [Line Items] | ||||||||
Convertible preferred shares authorized | unlimited | |||||||
Number of tranches | Tranche | 3 | |||||||
Beneficial conversion feature | $ 0 | |||||||
Series A Preferred Shares | First Tranche | ||||||||
Temporary Equity [Line Items] | ||||||||
Convertible preferred shares, par value | $ / shares | $ 4.91 | |||||||
Issuance of convertible preferred shares | shares | 5,906,049 | |||||||
Proceeds from Issuance of convertible preferred stock | $ 29,000,000 | |||||||
Stock issuance costs | 40,000 | |||||||
Conversion of convertible preferred shares into an equivalent number of common shares, Value | $ 4,500,000 | |||||||
Conversion of convertible preferred shares into an equivalent number of common shares, Shares | shares | 907,291 | |||||||
Series A Preferred Shares | Second Tranche | ||||||||
Temporary Equity [Line Items] | ||||||||
Convertible preferred shares, par value | $ / shares | $ 4.91 | |||||||
Issuance of convertible preferred shares | shares | 4,276,795 | |||||||
Proceeds from Issuance of convertible preferred stock | $ 21,000,000 | |||||||
Series A Preferred Shares | Maximum | ||||||||
Temporary Equity [Line Items] | ||||||||
Issuance of convertible preferred shares | shares | 13,237,696 | |||||||
Series A Preferred Shares | Maximum | First Tranche | ||||||||
Temporary Equity [Line Items] | ||||||||
Issuance of convertible preferred shares | shares | 7,331,647 | |||||||
Series B Preferred Shares | ||||||||
Temporary Equity [Line Items] | ||||||||
Convertible preferred shares authorized | unlimited | |||||||
Convertible preferred shares, par value | $ / shares | $ 7.88 | |||||||
Issuance of convertible preferred shares | shares | 10,468,258 | |||||||
Proceeds from Issuance of convertible preferred stock | $ 82,500,000 | |||||||
Beneficial conversion feature | $ 0 |
Shareholders' Equity - Addition
Shareholders' Equity - Additional Information (Details) - USD ($) | Nov. 01, 2021 | Jun. 23, 2020 | May 26, 2020 | Jun. 30, 2020 | May 31, 2020 | Dec. 31, 2021 | Dec. 31, 2020 | Jan. 01, 2022 |
Class Of Stock [Line Items] | ||||||||
Convertible preferred shares term | The Company’s Series A and Series B convertible preferred shares were convertible on a one-to-one basis into common shares. | |||||||
Preferred stock shares authorized | Unlimited | Unlimited | ||||||
Preferred stock shares issued | 0 | 0 | ||||||
Preferred stock shares outstanding | 0 | 0 | ||||||
Proceeds from issuance of warrant | $ 15,000,000 | |||||||
Common stock voting rights | Each common share entitles the holder to one vote on all matters submitted to the shareholders for a vote. | |||||||
Cash dividends declared or paid | $ 0 | |||||||
Net proceeds from issuance of common shares in initial public offering | $ 232,043,000 | |||||||
Net proceeds from issuance of common shares | $ 94,288,000 | |||||||
Common stock shares issued | 41,850,162 | 36,902,924 | ||||||
2020 Employee Share Purchase Plan | ||||||||
Class Of Stock [Line Items] | ||||||||
Shares issued, price per share | $ 28.46 | |||||||
Shares of common stock reserved for future issuance | 1,104,588 | |||||||
Annual increase in number of shares available for issuance as percentage of outstanding shares common stock on final day of preceding calendar year | 1.00% | |||||||
Annual increase in number of shares available for issuance maximum number of common stock issued | 3,300,000 | |||||||
Purchase price of shares as percentage of fair market value of common stock on date of purchase | 85.00% | |||||||
Common stock shares issued | 0 | 9,943 | ||||||
Maximum | 2020 Employee Share Purchase Plan | ||||||||
Class Of Stock [Line Items] | ||||||||
Shares of common stock reserved for future issuance | 327,000 | |||||||
Follow On Offering | ||||||||
Class Of Stock [Line Items] | ||||||||
Underwriting Commissions And Estimated Offering Expenses | $ 800,000 | |||||||
Affiliate of Bristol Myers Squibb | ||||||||
Class Of Stock [Line Items] | ||||||||
Proceeds from issuance of warrant | $ 15,000,000 | $ 15,000,000 | ||||||
Affiliate of Bristol Myers Squibb | Initial Public Offering | ||||||||
Class Of Stock [Line Items] | ||||||||
Warrant exercise price per share | $ 20 | |||||||
Common Shares | ||||||||
Class Of Stock [Line Items] | ||||||||
Convertible preferred shares converted into common shares | 21,558,393 | 21,558,393 | ||||||
Shares issued upon exercise of warrants outstanding | 750,000 | |||||||
Shares issued | 3,299 | |||||||
Shares issued, price per share | $ 20 | |||||||
Gross proceeds from IPO | $ 253,000,000 | |||||||
Net proceeds from issuance of common shares in initial public offering | $ 232,043,000 | |||||||
Common Shares | Initial Public Offering | ||||||||
Class Of Stock [Line Items] | ||||||||
Shares issued | 12,650,000 | 12,650,000 | ||||||
Common Shares | Exercise of Underwriters Option | ||||||||
Class Of Stock [Line Items] | ||||||||
Shares issued | 1,650,000 | |||||||
Common Shares | Exercise of Underwriters Option | Maximum | ||||||||
Class Of Stock [Line Items] | ||||||||
Shares issued | 600,000 | 1,650,000 | ||||||
Common Shares | Follow On Offering | ||||||||
Class Of Stock [Line Items] | ||||||||
Shares issued | 4,600,000 | 4,600,000 | ||||||
Shares issued, price per share | $ 22 | |||||||
Net proceeds from issuance of common shares | $ 94,300,000 | |||||||
Common Shares | Affiliate of Bristol Myers Squibb | ||||||||
Class Of Stock [Line Items] | ||||||||
Shares issued upon exercise of warrants outstanding | 750,000 |
Share-Based Compensation - Addi
Share-Based Compensation - Additional Information (Details) - USD ($) | 1 Months Ended | 12 Months Ended | ||||||
Jan. 31, 2022 | Jun. 30, 2020 | Dec. 31, 2021 | Dec. 31, 2020 | Dec. 31, 2019 | Feb. 28, 2022 | Jan. 01, 2022 | Jun. 23, 2020 | |
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] | ||||||||
Common stock shares issued | 41,850,162 | 36,902,924 | ||||||
Weighted average grant date fair value | $ 22.49 | $ 11.73 | $ 1.27 | |||||
Intrinsic value of options exercised | $ 8,500,000 | $ 5,700,000 | $ 0 | |||||
Fair value of options vested | $ 7,400,000 | 1,300,000 | $ 300,000 | |||||
Number of options exercised | 333,996 | |||||||
Exercised options, weighted-average exercise price | $ 2.96 | |||||||
Aggregate proceeds from exercise of options | $ 986,000 | $ 799,000 | ||||||
Decrease in additional paid-in capital as exercised options credited to common shares | 600,000 | |||||||
Unrecognized share-based compensation expense related to unvested stock options | $ 35,900,000 | |||||||
Unrecognized share-based compensation expense related to unvested stock options, weighted-average remaining vesting period | 2 years 1 month 6 days | |||||||
Stock options granted to employees | 1,645,416 | |||||||
Weighted average exercise price of stock options granted | $ 34.14 | |||||||
Common Shares | ||||||||
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] | ||||||||
Shares issued, price per share | $ 20 | |||||||
Number of options exercised | 333,996 | 416,157 | ||||||
2020 Employee Share Purchase Plan | ||||||||
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] | ||||||||
Shares of common stock reserved for future issuance | 1,104,588 | |||||||
Annual increase in number of shares available for issuance as percentage of outstanding shares common stock on final day of preceding calendar year | 1.00% | |||||||
Annual increase in number of shares available for issuance maximum number of common stock issued | 3,300,000 | |||||||
Purchase price of shares as percentage of fair market value of common stock on date of purchase | 85.00% | |||||||
Common stock shares issued | 0 | 9,943 | ||||||
Shares issued, price per share | $ 28.46 | |||||||
Weighted average grant date fair value | $ 10.94 | |||||||
Cash received from purchases under ESPP | $ 300,000 | |||||||
2020 Employee Share Purchase Plan | Subsequent Event | ||||||||
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] | ||||||||
Common stock shares issued | 16,807 | |||||||
Shares issued, price per share | $ 12.71 | |||||||
2020 Employee Share Purchase Plan | Maximum | ||||||||
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] | ||||||||
Shares of common stock reserved for future issuance | 327,000 | |||||||
Option Plan | ||||||||
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] | ||||||||
Shares of common stock reserved for future issuance | 298,605 | |||||||
Option Plan | Common Shares | ||||||||
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] | ||||||||
Number of shares authorized to be issued | 4,074,135 | |||||||
2020 Equity Incentive Plan | ||||||||
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] | ||||||||
Shares of common stock reserved for future issuance | 7,893,585 | |||||||
Annual increase in number of shares available for issuance as percentage of outstanding shares common stock on final day of preceding calendar year | 5.00% | |||||||
Exercise price per share as minimum percentage of fair value of common share | 100.00% | |||||||
Expiration period | 10 years | |||||||
Monthly vesting rate | 1/36th | |||||||
2020 Equity Incentive Plan | Vesting on First Anniversary Date of Grant | ||||||||
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] | ||||||||
Vesting percentage | 25.00% | |||||||
2020 Equity Incentive Plan | Vesting on Monthly Basis at Rate of 1/36th | ||||||||
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] | ||||||||
Vesting percentage | 75.00% | |||||||
2020 Equity Incentive Plan | Subsequent Event | ||||||||
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] | ||||||||
Stock options granted to employees | 2,203,467 | |||||||
Weighted average exercise price of stock options granted | $ 15.63 | |||||||
2020 Equity Incentive Plan | Maximum | ||||||||
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] | ||||||||
Shares of common stock initially reserved for future issuance | 3,600,000 | |||||||
Shares of common stock reserved for future issuance | 3,807,448 |
Share-Based Compensation - Sche
Share-Based Compensation - Schedule of Assumptions used to Determine Grant Date Fair Value under ESPP Offering (Details) | 12 Months Ended | ||
Dec. 31, 2021 | Dec. 31, 2020 | Dec. 31, 2019 | |
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] | |||
Risk-free interest rate | 0.80% | 0.45% | 1.94% |
Expected term (in years) | 6 years | 6 years 25 days | 6 years 1 month 6 days |
Expected volatility | 75.99% | 72.26% | 71.41% |
Expected dividend yield | 0.00% | 0.00% | 0.00% |
2020 Employee Share Purchase Plan | |||
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] | |||
Risk-free interest rate | 0.05% | ||
Expected term (in years) | 6 months | ||
Expected volatility | 61.91% | ||
Expected dividend yield | 0.00% |
Share-Based Compensation - Sc_2
Share-Based Compensation - Schedule of Fair Value of Stock Options Determined on Grant Date Using Black Scholes Option-Pricing Model (Details) | 12 Months Ended | ||
Dec. 31, 2021 | Dec. 31, 2020 | Dec. 31, 2019 | |
Disclosure Of Compensation Related Costs Sharebased Payments [Abstract] | |||
Risk-free interest rate | 0.80% | 0.45% | 1.94% |
Expected term (in years) | 6 years | 6 years 25 days | 6 years 1 month 6 days |
Expected volatility | 75.99% | 72.26% | 71.41% |
Expected dividend yield | 0.00% | 0.00% | 0.00% |
Share-Based Compensation - Sc_3
Share-Based Compensation - Schedule of Share Option Activity (Details) $ / shares in Units, $ in Thousands | 12 Months Ended |
Dec. 31, 2021USD ($)$ / sharesshares | |
Disclosure Of Compensation Related Costs Sharebased Payments [Abstract] | |
Number of shares, Outstanding at beginning of period | shares | 4,132,123 |
Number of shares, Granted | shares | 1,645,416 |
Number of shares, Exercised | shares | (333,996) |
Number of shares, Forfeited | shares | (120,952) |
Number of shares, Outstanding at end of period | shares | 5,322,591 |
Number of shares, Options Exercisable | shares | 2,090,060 |
Number of shares, Options Unvested | shares | 3,232,531 |
Weighted average exercise price, Outstanding at beginning of period | $ / shares | $ 6.39 |
Weighted average exercise price, Granted | $ / shares | 34.14 |
Weighted average exercise price, Exercised | $ / shares | 2.96 |
Weighted average exercise price, Forfeited | $ / shares | 25.26 |
Weighted average exercise price, Outstanding at end of period | $ / shares | 14.76 |
Weighted average exercise price, Options exercisable | $ / shares | 6.28 |
Weighted average exercise price, Options Unvested | $ / shares | $ 20.24 |
Weighted average remaining contractual term (in years) , Outstanding | 8 years 1 month 24 days |
Weighted average remaining contractual term (in years), Options Exercisable | 7 years 5 months 19 days |
Weighted average remaining contractual term (in years), Options Unvested | 8 years 7 months 2 days |
Intrinsic value, Outstanding at end of period | $ | $ 55,722 |
Intrinsic value, Options exercisable | $ | 32,409 |
Intrinsic value, Options unvested | $ | $ 23,313 |
Share-Based Compensation - Sc_4
Share-Based Compensation - Schedule of Share-based Compensation Expense for All Awards (Details) - USD ($) $ in Thousands | 12 Months Ended | ||
Dec. 31, 2021 | Dec. 31, 2020 | Dec. 31, 2019 | |
Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Line Items] | |||
Total share-based compensation expense | $ 12,829 | $ 2,537 | $ 511 |
Research and Development | |||
Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Line Items] | |||
Total share-based compensation expense | 5,681 | 890 | 250 |
General and Administrative | |||
Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Line Items] | |||
Total share-based compensation expense | $ 7,148 | $ 1,647 | $ 261 |
Share-Based Compensation - Sc_5
Share-Based Compensation - Schedule of Share-based Compensation Expense by Type of Award (Details) - USD ($) $ in Thousands | 12 Months Ended | ||
Dec. 31, 2021 | Dec. 31, 2020 | Dec. 31, 2019 | |
Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Line Items] | |||
Total share-based compensation expense | $ 12,829 | $ 2,537 | $ 511 |
Stock Options | |||
Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Line Items] | |||
Total share-based compensation expense | 12,632 | $ 2,537 | $ 511 |
ESPP | |||
Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Line Items] | |||
Total share-based compensation expense | $ 197 |
Employee Savings Plan - Additio
Employee Savings Plan - Additional Information (Details) - USD ($) $ in Millions | Jan. 01, 2021 | Dec. 31, 2021 |
Retirement Benefits [Abstract] | ||
Percentage of non-matching employer contributions | 3.00% | |
Matching contribution expense | $ 0.5 |
Collaborations - Additional Inf
Collaborations - Additional Information (Details) ¥ in Millions | May 26, 2020USD ($) | Jan. 01, 2019USD ($) | Jan. 01, 2019JPY (¥) | Jun. 30, 2020USD ($) | May 31, 2020USD ($) | Oct. 31, 2021USD ($) | Dec. 31, 2021USD ($) | Dec. 31, 2020USD ($) | Dec. 31, 2019USD ($) | Oct. 31, 2021JPY (¥) | Jun. 23, 2020shares | Jan. 01, 2019JPY (¥) |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] | ||||||||||||
Proceeds from issuance of warrant | $ 15,000,000 | |||||||||||
Common Shares | ||||||||||||
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] | ||||||||||||
Shares issued upon exercise of warrants outstanding | shares | 750,000 | |||||||||||
Collaboration and License Agreement | ||||||||||||
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] | ||||||||||||
Non-refundable upfront payment received | $ 8,100,000 | $ 8,100,000 | ¥ 900 | |||||||||
Initial nonrefundable upfront fee payment received | 1,000,000 | ¥ 110 | ||||||||||
Deferred revenue, additions | 6,500,000 | 750 | ||||||||||
Milestone payments entitled to be received | 3,900,000 | 450 | ||||||||||
Research, Development and Regulatory Milestones | Collaboration and License Agreement | ||||||||||||
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] | ||||||||||||
Initial nonrefundable upfront fee payment received | 7,100,000 | ¥ 790 | ||||||||||
Commercial Milestones | Collaboration and License Agreement | ||||||||||||
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] | ||||||||||||
Milestone payments entitled to be received | $ 149,500,000 | ¥ 17,210 | ||||||||||
Ono Pharmaceutical Co., Ltd. | Collaboration and License Agreement | ||||||||||||
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] | ||||||||||||
Collaboration term extended period | 1 year | |||||||||||
Milestone payments entitled to be received | $ 900,000 | ¥ 100 | ||||||||||
Deferred revenue, current | 9,000,000 | |||||||||||
Deferred revenue, noncurrent | 8,100,000 | |||||||||||
Affiliate of Bristol Myers Squibb | ||||||||||||
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] | ||||||||||||
Proceeds from issuance of warrant | $ 15,000,000 | $ 15,000,000 | ||||||||||
Affiliate of Bristol Myers Squibb | Common Shares | ||||||||||||
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] | ||||||||||||
Shares issued upon exercise of warrants outstanding | shares | 750,000 | |||||||||||
Bristol-Myers Squibb Company | ||||||||||||
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] | ||||||||||||
Non-refundable upfront payment received | 50,000,000 | |||||||||||
Bristol-Myers Squibb Company | Collaboration and License Agreement | ||||||||||||
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] | ||||||||||||
Non-refundable upfront payment received | $ 50,000,000 | |||||||||||
Initial nonrefundable upfront fee payment received | $ 50,000,000 | |||||||||||
Revenue recognized | 6,500,000 | 0 | $ 0 | |||||||||
Collaboration term expiration period | 42 months | |||||||||||
Deferred revenue recognized | 1,100,000 | 100,000 | $ 0 | |||||||||
Deferred revenue | 42,500,000 | 49,900,000 | ||||||||||
Deferred revenue, current | 2,900,000 | 2,100,000 | ||||||||||
Deferred revenue, noncurrent | $ 39,600,000 | $ 47,800,000 | ||||||||||
Bristol-Myers Squibb Company | Collaboration and License Agreement | Maximum | ||||||||||||
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] | ||||||||||||
Milestone payments entitled to be received | $ 301,000,000 | |||||||||||
Bristol-Myers Squibb Company | Research, Development and Regulatory Milestones | Collaboration and License Agreement | Maximum | ||||||||||||
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] | ||||||||||||
Milestone payments entitled to be received | 176,000,000 | |||||||||||
Bristol-Myers Squibb Company | Commercial Milestones | Collaboration and License Agreement | Maximum | ||||||||||||
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] | ||||||||||||
Milestone payments entitled to be received | $ 125,000,000 |
Collaborations - Schedule of Tr
Collaborations - Schedule of Transaction Price Performance Obligations (Details) - Bristol-Myers Squibb Company $ in Thousands | Dec. 31, 2020USD ($) |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] | |
Transaction price | $ 50,000 |
Research Activities | |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] | |
Transaction price | 6,405 |
Options to License Druggable Targets | |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] | |
Transaction price | 31,148 |
Options to License Undruggable Targets | |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] | |
Transaction price | $ 12,447 |
Income Taxes - Summary of Loss
Income Taxes - Summary of Loss Before Provision for Income Taxes (Details) - USD ($) $ in Thousands | 12 Months Ended | ||
Dec. 31, 2021 | Dec. 31, 2020 | Dec. 31, 2019 | |
Income Tax Disclosure [Abstract] | |||
Canada | $ (110,433) | $ (55,446) | $ (27,355) |
Foreign | 1,847 | 704 | 334 |
Loss before income taxes | $ (108,586) | $ (54,742) | $ (27,021) |
Income Taxes - Summary of provi
Income Taxes - Summary of provision for income taxes (Details) - USD ($) $ in Thousands | 12 Months Ended | ||
Dec. 31, 2021 | Dec. 31, 2020 | Dec. 31, 2019 | |
Income Tax Disclosure [Abstract] | |||
Current income tax provision - foreign | $ 530 | $ (45) | $ 327 |
Deferred income tax benefit - foreign | (2,208) | (1,280) | (132) |
Tax (benefit) expense | $ (1,678) | $ (1,325) | $ 195 |
Income Taxes - Summary of Recon
Income Taxes - Summary of Reconciliation of Provision for Income Taxes (Details) - USD ($) $ in Thousands | 12 Months Ended | ||
Dec. 31, 2021 | Dec. 31, 2020 | Dec. 31, 2019 | |
Income Tax Disclosure [Abstract] | |||
Loss before income taxes | $ (108,586) | $ (54,742) | $ (27,021) |
Income tax at statutory rate | 26.50% | 26.50% | 26.50% |
Computed income tax recovery | $ (28,775) | $ (14,507) | $ (7,160) |
Federal investment tax credit | (4,093) | (2,347) | (985) |
Accounting charges not deductible for tax purposes | 1,078 | 1,088 | 143 |
Equity compensation | 2,220 | (742) | 134 |
Other | 644 | (306) | (16) |
Change in valuation allowance | 27,248 | 15,489 | 8,079 |
Tax (benefit) expense | $ (1,678) | $ (1,325) | $ 195 |
Income Taxes - Additional Infor
Income Taxes - Additional Information (Details) - USD ($) | 12 Months Ended | |
Dec. 31, 2021 | Dec. 31, 2020 | |
Income Taxes [Line Items] | ||
Income tax losses | $ 113,560,000 | |
Scientific research and experimental development expenditures | 40,200,000 | |
Investment tax credits | $ 6,536,000 | |
Tax examination | 2017 2018 2019 2020 2021 | |
Unrecognized tax positions | $ 0 | $ 0 |
Accrued interest or penalties | 0 | $ 0 |
U.S. Federal Research and Development | ||
Income Taxes [Line Items] | ||
Tax credit carryforward, amount | $ 1,500,000 | |
Tax credit carry forward expiration year | 2041 | |
U.S. State Research and Development | ||
Income Taxes [Line Items] | ||
Tax credit carryforward, amount | $ 300,000 | |
Tax credit carry forward expiration year | 2036 |
Income Taxes - Summary of Losse
Income Taxes - Summary of Losses Expire (Details) $ in Thousands | 12 Months Ended |
Dec. 31, 2021USD ($) | |
Income Tax Disclosure [Abstract] | |
2041 | $ 94,231 |
2039 | 11,394 |
2038 | 7,052 |
2037 | 883 |
Total | $ 113,560 |
Income Taxes - Summary of Inves
Income Taxes - Summary of Investment Tax Credits Expire (Details) $ in Thousands | Dec. 31, 2021USD ($) |
Income Tax Disclosure [Abstract] | |
2041 | $ 2,217 |
2040 | 1,702 |
2039 | 1,362 |
2038 | 776 |
2037 | 455 |
2036 | 24 |
Total | $ 6,536 |
Income Taxes - Summary of Defer
Income Taxes - Summary of Deferred Tax Assets (Details) - USD ($) $ in Thousands | Dec. 31, 2021 | Dec. 31, 2020 |
Income Tax Disclosure [Abstract] | ||
Net operating loss carryforwards | $ 30,093 | $ 5,087 |
Net research and development expenditures | 10,656 | 7,478 |
Share issuance costs | 3,538 | 4,506 |
Net federal investment tax credits | 4,805 | 3,181 |
U.S. research and development tax credits | 1,775 | 961 |
Tax basis of property and equipment in excess of carrying values | (86) | |
Operating lease right-of-use assets | (1,995) | (1,240) |
Operating lease liability | 1,950 | 1,063 |
Accrued expense and other liabilities | 760 | 345 |
Deferred revenue | 13,656 | 15,372 |
Share-based compensation | 988 | 103 |
Total deferred tax assets | 66,226 | 36,770 |
Valuation allowance | (62,606) | (35,358) |
Net deferred tax assets | $ 3,620 | $ 1,412 |
Net Loss per Share - Summary of
Net Loss per Share - Summary of Basic and Diluted Net Loss per Share Attributable to Common Stockholders (Details) - USD ($) $ / shares in Units, $ in Thousands | 12 Months Ended | ||
Dec. 31, 2021 | Dec. 31, 2020 | Dec. 31, 2019 | |
Numerator: | |||
Net loss attributable to common shareholders | $ (106,908) | $ (53,417) | $ (27,216) |
Net loss attributable to common shareholders—basic and diluted | $ (106,908) | $ (53,417) | $ (27,216) |
Denominator: | |||
Weighted-average common shares outstanding—basic and diluted | 37,818,115 | 20,045,602 | 1,528,374 |
Net loss per share attributable to common shareholders—basic and diluted | $ (2.83) | $ (2.66) | $ (17.81) |
Net Loss per Share - Computatio
Net Loss per Share - Computation of Diluted Net Loss Per Share in Attributable to Common Shareholders Indicate to Anti Diluted Effect (Details) - shares | 12 Months Ended | ||
Dec. 31, 2021 | Dec. 31, 2020 | Dec. 31, 2019 | |
Options to Purchase Common Shares | |||
Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items] | |||
Antidilutive securities excluded from computation of earnings per share amount | 5,322,591 | 4,132,123 | 3,505,119 |
Series A Preferred Shares | |||
Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items] | |||
Antidilutive securities excluded from computation of earnings per share amount | 11,090,135 | ||
Series B Preferred Shares | |||
Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items] | |||
Antidilutive securities excluded from computation of earnings per share amount | 10,468,258 |
Government Assistance - Additio
Government Assistance - Additional Information (Details) - USD ($) $ in Millions | 12 Months Ended | ||
Dec. 31, 2021 | Dec. 31, 2020 | Dec. 31, 2019 | |
Research And Development [Abstract] | |||
Reduction of research and development expenditures | $ 1.1 | $ 0.9 | $ 0.6 |
Commitments and Contingencies -
Commitments and Contingencies - Schedule of Commitments to Settle Contractual Obligations (Details) $ in Thousands | Dec. 31, 2021USD ($) |
Commitments And Contingencies Disclosure [Abstract] | |
2022 | $ 2,449 |
2023 | 2,333 |
2024 | 2,349 |
2025 | 33 |
2026 | 49 |
Following years | 32 |
Total | $ 7,245 |
Commitments and Contingencies_2
Commitments and Contingencies - Additional Information (Details) - USD ($) | 1 Months Ended | 12 Months Ended |
Mar. 31, 2020 | Dec. 31, 2021 | |
Maximum | Research and Development Service Agreement | ||
Commitments And Contingencies Disclosure [Line Items] | ||
Potential payment for milestone | $ 1,750,000 | |
Termination payments | 500,000 | |
Preclinical Studies and Clinical Trials | MDACC | ||
Commitments And Contingencies Disclosure [Line Items] | ||
Contractual obligation | $ 10,000,000 | |
Contractual obligation period | 5 years | |
Contractual obligation paid | $ 3,000,000 |
Currency Risk - Schedule of Fin
Currency Risk - Schedule of Financial Position Exposure (Details) - CAD ($) $ in Thousands | Dec. 31, 2021 | Dec. 31, 2020 |
Foreign Currency Risk [Line Items] | ||
Net financial position exposure | $ (756) | $ 881 |
Cash | ||
Foreign Currency Risk [Line Items] | ||
Assets exposure | 3,583 | 1,715 |
Restricted Cash | ||
Foreign Currency Risk [Line Items] | ||
Assets exposure | 270 | |
Research and Development Tax Credits Receivable | ||
Foreign Currency Risk [Line Items] | ||
Assets exposure | 3,261 | 2,559 |
Other Receivables | ||
Foreign Currency Risk [Line Items] | ||
Assets exposure | 745 | 5,228 |
Accounts Payable | ||
Foreign Currency Risk [Line Items] | ||
Liability exposure | (665) | (1,322) |
Accrued Expenses and Other Current Liabilities | ||
Foreign Currency Risk [Line Items] | ||
Liability exposure | (2,116) | (2,722) |
Lease Liabilities | ||
Foreign Currency Risk [Line Items] | ||
Liability exposure | $ (5,564) | $ (4,847) |
Currency Risk - Additional Info
Currency Risk - Additional Information (Details) $ in Millions | 12 Months Ended |
Dec. 31, 2021USD ($) | |
Foreign Currency Risk [Abstract] | |
Percentage of depreciation USD against Canadian dollar | 10.00% |
Increase in net loss currency risk | $ 0.1 |
Related Parties - Additional In
Related Parties - Additional Information (Details) - USD ($) | 12 Months Ended | ||
Dec. 31, 2021 | Dec. 31, 2020 | Dec. 31, 2019 | |
Related Party Transaction [Line Items] | |||
Expenses from transactions with related party | $ 0 | $ 0 | |
Affiliated Entity | Accounts Payable and Accrued Expense and Other Current Liabilities | |||
Related Party Transaction [Line Items] | |||
Due to related parties | $ 0 | $ 0 | |
Research Services and Rent Paid | Affiliated Entity | |||
Related Party Transaction [Line Items] | |||
Expenses from transactions with related party | $ 1,300,000 |
Geographic Information - Schedu
Geographic Information - Schedule of Property and Equipment, Net by Location (Details) - USD ($) $ in Thousands | Dec. 31, 2021 | Dec. 31, 2020 |
Segment Reporting Information [Line Items] | ||
Property and equipment, net | $ 5,604 | $ 3,948 |
Canada | ||
Segment Reporting Information [Line Items] | ||
Property and equipment, net | 3,675 | 3,845 |
United States | ||
Segment Reporting Information [Line Items] | ||
Property and equipment, net | $ 1,929 | $ 103 |
Geographic Information - Sche_2
Geographic Information - Schedule of Right-of-Use Assets by Location (Details) - USD ($) $ in Thousands | Dec. 31, 2021 | Dec. 31, 2020 |
Segment Reporting Information [Line Items] | ||
Operating lease right-of-use assets | $ 7,491 | $ 4,674 |
Canada | ||
Segment Reporting Information [Line Items] | ||
Operating lease right-of-use assets | 4,939 | 4,483 |
United States | ||
Segment Reporting Information [Line Items] | ||
Operating lease right-of-use assets | $ 2,552 | $ 191 |
Geographic Information - Additi
Geographic Information - Additional Information (Details) - USD ($) $ in Millions | 12 Months Ended | ||
Dec. 31, 2021 | Dec. 31, 2020 | Dec. 31, 2019 | |
United States | Customer | |||
Segment Reporting Information [Line Items] | |||
Revenue | $ 7.6 | $ 0.1 |