Exhibit 23.1
Consent of Independent Registered Public Accounting Firm
We consent to the incorporation by reference in the Registration Statement (Form S-8) pertaining to the Repare Therapeutics 2020 Equity Incentive Plan and the Repare Therapeutics 2020 Employee Share Purchase Plan of our report dated March 4, 2021, with respect to the consolidated financial statements of Repare Therapeutics Inc. included in its Annual Report (Form 10-K) for the year ended December 31, 2020, filed with the Securities and Exchange Commission.
/s/ Ernst & Young LLP
Montreal, Canada
April 5, 2021