![LOGO](https://capedge.com/proxy/DEFA14A/0001193125-22-093625/g287450pc0001.jpg) P.O. BOX 8016, CARY, NC 27512-9903 | | Repare Therapeutics Inc. Important Notice Regarding the Availability of Proxy Materials Shareholders Meeting to be held on May 13, 2022 For Shareholders of record as of March 21, 2022 This communication presents only an overview of the more complete proxy materials that are available to you on the Internet. This is not a ballot. You cannot use this notice to vote your shares. We encourage you to access and review all of the important information contained in the proxy materials before voting. To appoint a third party proxyholder, a shareholder of record must return its proxy card by mail in accordance with the instructions provided in the proxy materials by no later than by 10:00 A.M., Eastern Time, on May 11, 2022. To view the proxy materials, and to obtain directions to attend the meeting, go to: www.proxydocs.com/RPTX To vote your proxy while visiting this site, you will need the 12 digit control number in the box below. Under United States Securities and Exchange Commission rules, proxy materials do not have to be delivered in paper. Proxy materials can be distributed by making them available on the internet. |