| Document and Entity Information | May 09, 2022 |
| Cover [Abstract] | |
| Document Type | 8-K |
| Amendment Flag | false |
| Document Period End Date | May 9, 2022 |
| Entity Registrant Name | ALX ONCOLOGY HOLDINGS INC. |
| Entity Central Index Key | 0001810182 |
| Entity Emerging Growth Company | false |
| Entity File Number | 001-39386 |
| Entity Incorporation, State or Country Code | DE |
| Entity Tax Identification Number | 85-0642577 |
| Entity Address, Address Line One | 323 Allerton Avenue |
| Entity Address, City or Town | South San Francisco |
| Entity Address, State or Province | CA |
| Entity Address, Postal Zip Code | 94080 |
| City Area Code | 650 |
| Local Phone Number | 466-7125 |
| Written Communications | false |
| Soliciting Material | false |
| Pre-commencement Tender Offer | false |
| Pre-commencement Issuer Tender Offer | false |
| Security 12b Title | Common Stock, $0.001 par value per share |
| Trading Symbol | ALXO |
| Security Exchange Name | NASDAQ |
