Document and Entity Information
Document and Entity Information - shares | 6 Months Ended | |
Jun. 30, 2020 | Aug. 21, 2020 | |
Cover [Abstract] | ||
Document Type | 10-Q | |
Amendment Flag | false | |
Document Period End Date | Jun. 30, 2020 | |
Document Fiscal Year Focus | 2020 | |
Document Fiscal Period Focus | Q2 | |
Current Fiscal Year End Date | --12-31 | |
Entity Registrant Name | ALX ONCOLOGY HOLDINGS INC | |
Entity Central Index Key | 0001810182 | |
Entity File Number | 001-39386 | |
Entity Tax Identification Number | 85-0642577 | |
Entity Incorporation, State or Country Code | DE | |
Entity Address, Address Line One | 866 Malcolm Road | |
Entity Address, Address Line Two | Suite 100 | |
Entity Address, City or Town | Burlingame | |
Entity Address, State or Province | CA | |
Entity Address, Postal Zip Code | 94010 | |
City Area Code | 650 | |
Local Phone Number | 466-7125 | |
Entity Current Reporting Status | No | |
Entity Interactive Data Current | Yes | |
Entity Filer Category | Non-accelerated Filer | |
Entity Small Business | false | |
Entity Emerging Growth Company | true | |
Entity Ex Transition Period | false | |
Entity Common Stock, Shares Outstanding | 36,967,320 | |
Entity Shell Company | false | |
Title of 12(b) Security | Common Stock, par value $0.001 per share | |
Trading Symbol | ALXO | |
Security Exchange Name | NASDAQ | |
Document Quarterly Report | true | |
Document Transition Report | false |
Condensed Consolidated Balance
Condensed Consolidated Balance Sheets (Unaudited) - USD ($) $ in Thousands | Jun. 30, 2020 | Dec. 31, 2019 |
Current assets: | ||
Cash and cash equivalents | $ 98,103 | $ 9,017 |
Receivables due from related-party | 527 | 536 |
Prepaid expenses and other current assets | 1,393 | 256 |
Assets held for sale | 641 | |
Total current assets | 100,664 | 9,809 |
Property and equipment, net | 37 | 860 |
Other assets | 2,411 | 7 |
Total assets | 103,112 | 10,676 |
Current liabilities: | ||
Accounts payable | 1,865 | 3,748 |
Accrued expenses and other current liabilities | 4,140 | 1,236 |
Term loan - current | 1,714 | |
Total current liabilities | 7,719 | 4,984 |
Term loan - non-current | 3,928 | 5,421 |
Other non-current liabilities | 820 | 412 |
Deferred rent | 135 | |
Total liabilities | 12,467 | 10,952 |
Commitments and contingencies (Note 11) | ||
Convertible preferred stock | 175,043 | 70,363 |
Stockholders’ deficit | ||
Common stock, $0.001 par value; 1,519,618,271 shares authorized; 3,166,946 shares issued and outstanding at June 30, 2020 and December 31, 2019, respectively | 3 | 3 |
Additional paid-in capital | 5,166 | 2,140 |
Accumulated deficit | (89,567) | (72,782) |
Total stockholders’ deficit | (84,398) | (70,639) |
Total liabilities, convertible preferred stock and stockholders’ deficit | 103,112 | 10,676 |
Series A Convertible Preferred Stock | ||
Current liabilities: | ||
Convertible preferred stock | 60,933 | 60,933 |
Series B Convertible Preferred Stock | ||
Current liabilities: | ||
Convertible preferred stock | 9,430 | $ 9,430 |
Series C Convertible Preferred Stock | ||
Current liabilities: | ||
Convertible preferred stock | $ 104,680 |
Condensed Consolidated Balanc_2
Condensed Consolidated Balance Sheets (Unaudited) (Parenthetical) - USD ($) $ in Thousands | Jun. 30, 2020 | Dec. 31, 2019 |
Convertible preferred stock, shares authorized | 21,461,756 | 11,567,003 |
Convertible preferred stock, liquidation preference | $ 193,220 | $ 83,585 |
Common stock, par value | $ 0.001 | $ 0.001 |
Common stock, shares authorized | 1,519,618,271 | 1,519,618,271 |
Common stock, shares issued | 3,166,946 | 3,166,946 |
Common stock, shares outstanding | 3,166,946 | 3,166,946 |
Series A Convertible Preferred Stock | ||
Convertible preferred stock, par value | $ 0.001 | $ 0.001 |
Convertible preferred stock, shares authorized | 9,297,100 | 9,421,633 |
Convertible preferred stock, shares issued | 9,297,081 | 9,297,081 |
Convertible preferred stock, shares outstanding | 9,297,081 | 9,297,081 |
Convertible preferred stock, liquidation preference | $ 75,412 | $ 73,571 |
Series B Convertible Preferred Stock | ||
Convertible preferred stock, par value | $ 0.001 | $ 0.001 |
Convertible preferred stock, shares authorized | 1,108,675 | 2,145,370 |
Convertible preferred stock, shares issued | 1,016,727 | 1,016,727 |
Convertible preferred stock, shares outstanding | 1,016,727 | 1,016,727 |
Convertible preferred stock, liquidation preference | $ 10,304 | $ 10,014 |
Series C Convertible Preferred Stock | ||
Convertible preferred stock, par value | $ 0.001 | $ 0.001 |
Convertible preferred stock, shares authorized | 11,055,981 | 0 |
Convertible preferred stock, shares issued | 11,055,966 | 0 |
Convertible preferred stock, shares outstanding | 11,055,966 | 0 |
Convertible preferred stock, liquidation preference | $ 107,504 | $ 0 |
Condensed Consolidated Statemen
Condensed Consolidated Statements of Operations and Comprehensive Loss (unaudited) - USD ($) $ in Thousands | 3 Months Ended | 6 Months Ended | ||
Jun. 30, 2020 | Jun. 30, 2019 | Jun. 30, 2020 | Jun. 30, 2019 | |
Income Statement [Abstract] | ||||
Related-party revenue | $ 527 | $ 1,295 | $ 1,182 | $ 2,327 |
Type of Revenue [Extensible List] | alxo:RelatedPartyMember | alxo:RelatedPartyMember | alxo:RelatedPartyMember | alxo:RelatedPartyMember |
Operating expenses: | ||||
Research and development | $ 7,663 | $ 3,628 | $ 11,491 | $ 7,361 |
General and administrative | 3,172 | 679 | 4,645 | 1,267 |
Cost of services for related-party revenue | 479 | 1,177 | 1,075 | 2,115 |
Total operating expenses | 11,314 | 5,484 | 17,211 | 10,743 |
Loss from operations | (10,787) | (4,189) | (16,029) | (8,416) |
Interest expense | (219) | (434) | ||
Other expense, net | (305) | (298) | (2) | |
Loss before income taxes | (11,311) | (4,189) | (16,761) | (8,418) |
Income tax provision | (20) | (8) | (24) | (17) |
Net loss and comprehensive loss | (11,331) | (4,197) | (16,785) | (8,435) |
Cumulative dividends allocated to preferred stockholders | (2,641) | (981) | (4,624) | (1,886) |
Net loss attributable to common stockholders | $ (13,972) | $ (5,178) | $ (21,409) | $ (10,321) |
Net loss per share attributable to common stockholders, basic and diluted | $ (4.41) | $ (1.68) | $ (6.78) | $ (3.39) |
Weighted-average shares of common stock used to compute net loss per share attributable to common stockholders, basic and diluted | 3,164,707 | 3,087,355 | 3,157,387 | 3,047,924 |
Condensed Consolidated Statem_2
Condensed Consolidated Statements of Convertible Preferred Stock and Stockholders' Deficit (Unaudited) - USD ($) $ in Thousands | Total | Convertible Preferred Stock | Common Stock | Additional Paid-In Capital | Accumulated Deficit |
Balance at Dec. 31, 2018 | $ (51,778) | $ 3 | $ 1,758 | $ (53,539) | |
Temporary equity, shares at Dec. 31, 2018 | 9,297,081 | ||||
Temporary equity, balance at Dec. 31, 2018 | $ 60,933 | ||||
Balance, shares at Dec. 31, 2018 | 3,161,747 | ||||
Vesting of early exercised stock options | 21 | 21 | |||
Stock-based compensation | 76 | 76 | |||
Net loss | (4,238) | (4,238) | |||
Balance at Mar. 31, 2019 | (55,919) | $ 3 | 1,855 | (57,777) | |
Temporary equity, shares at Mar. 31, 2019 | 9,297,081 | ||||
Temporary equity, balance at Mar. 31, 2019 | $ 60,933 | ||||
Balance, shares at Mar. 31, 2019 | 3,161,747 | ||||
Balance at Dec. 31, 2018 | (51,778) | $ 3 | 1,758 | (53,539) | |
Temporary equity, shares at Dec. 31, 2018 | 9,297,081 | ||||
Temporary equity, balance at Dec. 31, 2018 | $ 60,933 | ||||
Balance, shares at Dec. 31, 2018 | 3,161,747 | ||||
Net loss | (8,435) | ||||
Balance at Jun. 30, 2019 | (60,036) | $ 3 | 1,935 | (61,974) | |
Temporary equity, shares at Jun. 30, 2019 | 10,313,808 | ||||
Temporary equity, balance at Jun. 30, 2019 | $ 70,363 | ||||
Balance, shares at Jun. 30, 2019 | 3,161,747 | ||||
Balance at Mar. 31, 2019 | (55,919) | $ 3 | 1,855 | (57,777) | |
Temporary equity, shares at Mar. 31, 2019 | 9,297,081 | ||||
Temporary equity, balance at Mar. 31, 2019 | $ 60,933 | ||||
Balance, shares at Mar. 31, 2019 | 3,161,747 | ||||
Vesting of early exercised stock options | 20 | 20 | |||
Stock-based compensation | 60 | 60 | |||
Net loss | (4,197) | (4,197) | |||
Issuance of convertible preferred stock, net of issuance costs | $ 9,430 | ||||
Issuance of convertible preferred stock, net of issuance costs, shares | 1,016,727 | ||||
Balance at Jun. 30, 2019 | (60,036) | $ 3 | 1,935 | (61,974) | |
Temporary equity, shares at Jun. 30, 2019 | 10,313,808 | ||||
Temporary equity, balance at Jun. 30, 2019 | $ 70,363 | ||||
Balance, shares at Jun. 30, 2019 | 3,161,747 | ||||
Balance at Dec. 31, 2019 | (70,639) | $ 3 | 2,140 | (72,782) | |
Temporary equity, shares at Dec. 31, 2019 | 10,313,808 | ||||
Temporary equity, balance at Dec. 31, 2019 | 70,363 | $ 70,363 | |||
Balance, shares at Dec. 31, 2019 | 3,166,946 | ||||
Vesting of early exercised stock options | 16 | 16 | |||
Stock-based compensation | 151 | 151 | |||
Net loss | (5,454) | (5,454) | |||
Issuance of convertible preferred stock, net of issuance costs | $ 104,680 | ||||
Issuance of convertible preferred stock, net of issuance costs, shares | 11,055,966 | ||||
Balance at Mar. 31, 2020 | (75,926) | $ 3 | 2,307 | (78,236) | |
Temporary equity, shares at Mar. 31, 2020 | 21,369,774 | ||||
Temporary equity, balance at Mar. 31, 2020 | $ 175,043 | ||||
Balance, shares at Mar. 31, 2020 | 3,166,946 | ||||
Balance at Dec. 31, 2019 | (70,639) | $ 3 | 2,140 | (72,782) | |
Temporary equity, shares at Dec. 31, 2019 | 10,313,808 | ||||
Temporary equity, balance at Dec. 31, 2019 | 70,363 | $ 70,363 | |||
Balance, shares at Dec. 31, 2019 | 3,166,946 | ||||
Net loss | (16,785) | ||||
Balance at Jun. 30, 2020 | (84,398) | $ 3 | 5,166 | (89,567) | |
Temporary equity, shares at Jun. 30, 2020 | 21,369,774 | ||||
Temporary equity, balance at Jun. 30, 2020 | 175,043 | $ 175,043 | |||
Balance, shares at Jun. 30, 2020 | 3,166,946 | ||||
Balance at Mar. 31, 2020 | (75,926) | $ 3 | 2,307 | (78,236) | |
Temporary equity, shares at Mar. 31, 2020 | 21,369,774 | ||||
Temporary equity, balance at Mar. 31, 2020 | $ 175,043 | ||||
Balance, shares at Mar. 31, 2020 | 3,166,946 | ||||
Vesting of early exercised stock options | 6 | 6 | |||
Stock-based compensation | 2,853 | 2,853 | |||
Net loss | (11,331) | (11,331) | |||
Balance at Jun. 30, 2020 | (84,398) | $ 3 | $ 5,166 | $ (89,567) | |
Temporary equity, shares at Jun. 30, 2020 | 21,369,774 | ||||
Temporary equity, balance at Jun. 30, 2020 | $ 175,043 | $ 175,043 | |||
Balance, shares at Jun. 30, 2020 | 3,166,946 |
Condensed Consolidated Statem_3
Condensed Consolidated Statements of Cash Flows (unaudited) - USD ($) $ in Thousands | 6 Months Ended | |
Jun. 30, 2020 | Jun. 30, 2019 | |
Operating activities | ||
Net loss | $ (16,785) | $ (8,435) |
Adjustments to reconcile net loss to net cash used in operating activities: | ||
Depreciation and amortization | 192 | 206 |
Stock-based compensation | 3,004 | 136 |
Amortization of term loan discount and issuance costs | 221 | |
Changes in fair value of compound derivative liability and warrants | 408 | |
Changes in operating assets and liabilities | ||
Receivables due from related-party | 9 | (418) |
Prepaid expenses and other current assets | (1,137) | 327 |
Accounts payable | (2,003) | 476 |
Accrued expenses and other current liabilities | 1,100 | (483) |
Deferred rent | (135) | 2 |
Net cash used in operating activities | (15,126) | (8,189) |
Investing activities | ||
Purchase of property and equipment | (10) | (415) |
Net cash used in investing activities | (10) | (415) |
Financing activities | ||
Proceeds from related parties for issuance of convertible preferred stock, net of issuance costs | 68,452 | 6,829 |
Proceeds from issuance of convertible preferred stock, net of issuance costs | 36,228 | 2,601 |
Deferred offering costs | (458) | |
Net cash provided by financing activities | 104,222 | 9,430 |
Net increase in cash and cash equivalents | 89,086 | 826 |
Cash and cash equivalents at beginning of period | 9,017 | 8,262 |
Cash and cash equivalents at end of period | 98,103 | 9,088 |
Supplemental disclosure | ||
Cash paid for interest | 188 | |
Supplemental disclosure of non-cash investing and financing activities | ||
Vesting of early exercised stock options | 22 | $ 41 |
Deferred offering costs incurred but not paid | $ 1,953 |
Organization
Organization | 6 Months Ended |
Jun. 30, 2020 | |
Accounting Policies [Abstract] | |
ORGANIZATION | (1) ORGANIZATION Organization ALX Oncology Holdings Inc., or the Company, was formed as a Delaware corporation on April 1, 2020, or Inception. The Company was formed for the purpose of completing the Company’s initial public offering of its common stock and related transactions in order to carry on the business of ALX Oncology Limited. After Inception, ALX Oncology Limited became a wholly-owned subsidiary of the Company as a result of the internal reorganization. As part of the internal reorganization, all of the equity, option and warrant holders of ALX Oncology Limited became equity, option and warrant holders of the Company, holding the same number of corresponding shares, options and/or warrants in the Company as they did in ALX Oncology Limited immediately prior to the internal reorganization. The information included herein is presented as that of ALX Oncology Holdings Inc. unless such information refers to a date prior to April 1, 2020, in which case it will reflect that of ALX Oncology Limited, the predecessor company. The Company is a clinical-stage immuno-oncology company focused on helping patients fight cancer by developing therapies that block the CD47 checkpoint pathway and bridge the innate and adaptive immune system. The Company owns subsidiaries, consisting of ALX Oncology Limited, incorporated in Ireland; ALX Oncology Inc., incorporated in the United States, and Alexo International Holdings Ltd, incorporated in Malta; Alexo Therapeutics International, incorporated in the Cayman Islands, which is a wholly-owned subsidiary of Alexo International Holdings Ltd. and Sirpant Therapeutics, incorporated in the Cayman Islands, which is a wholly-owned subsidiary of Alexo Therapeutics International, or collectively, the Subsidiaries. As of June 30, 2020, the Company has devoted substantially all of its efforts to the formation and financing of the Company, as well as product development, and has not realized product revenues from its planned principal operations. The Company has no manufacturing facilities and all manufacturing related activities are contracted out to third-party service providers. Liquidity and Capital Resources In July 2020, the Company consummated its initial public offering and issued 9,775,000 shares of common stock for net proceeds of approximately $172.7 million, after deducting underwriting discounts and commissions of $13.0 million and before deducting offering-related expenses. Upon the closing of the initial public offering, all shares of convertible preferred stock outstanding and accrued cumulative dividends were automatically converted into 23,934,533 shares of common stock. See Note 12 to these condensed consolidated financial statements for additional details. As of June 30, 2020, the Company had cash and cash equivalents of $98.1 million, together with net proceeds from the Company’s initial public offering of $172.7 million, will be sufficient to fund its planned operations for a period of at least twelve months following the issuance of these financial statements. Management expects to incur additional losses in the future to conduct product candidate research and development and to conduct pre-commercialization activities and recognizes the need to raise additional capital to fully implement its business plan. The Company intends to raise such capital through the sale of additional equity, debt financings or strategic alliances with third parties. However, there can be no assurance that the Company will be successful in acquiring additional funding at levels sufficient to fund its operations or on terms acceptable to the Company. If the Company is unsuccessful in its efforts to raise additional financing, the Company could be required to significantly reduce operating expenses and delay, reduce the scope of or eliminate some of its development programs or its future commercialization efforts, out-license intellectual property rights to its product candidates and sell unsecured assets, or a combination of the above, any of which may have a material adverse effect on the Company’s business, results of operations, financial condition and/or its ability to fund its scheduled obligations on a timely basis or at all. |
Significant Accounting Policies
Significant Accounting Policies | 6 Months Ended |
Jun. 30, 2020 | |
Accounting Policies [Abstract] | |
SIGNIFICANT ACCOUNTING POLICIES | (2) SIGNIFICANT ACCOUNTING POLICIES Basis of Preparation These condensed consolidated financial statements have been prepared in accordance with accounting principles generally accepted in the United States of America, or U.S. GAAP, and the applicable rules and regulations of the U.S. Securities and Exchange Commission, or SEC, for interim reporting. Principles of Consolidation All intercompany balances and transactions have been eliminated in consolidation. Unaudited Condensed Consolidated Financial Statements The condensed consolidated balance sheet as of June 30, 2020, the condensed consolidated statements of operations and comprehensive loss for the three and six months ended June 30, 2020 and 2019, the condensed consolidated statements of convertible preferred stock and stockholders' deficit for the three and six months ended June 30, 2020 and 2019, and the condensed consolidated statements of cash flows for the six months ended June 30, 2020 and 2019, are unaudited. These unaudited condensed consolidated financial statements have been prepared on the same basis as the annual consolidated financial statements and, in the opinion of management, reflect all adjustments, which include only normal recurring adjustments, necessary to present fairly the Company’s financial position as of June 30, 2020, and its results of operations for the periods presented. The results of operations for the three and six months ended June 30, 2020, are not necessarily indicative of the results to be expected for any subsequent periods, including the year ended December 31, 2020, and therefore should not be relied upon as an indicator of future results. The condensed consolidated balance sheet as of December 31, 2019 included herein was derived from the audited consolidated financial statements as of that date. The accompanying condensed consolidated financial statements and related notes should be read in conjunction with the audited consolidated financial statements for the year ended December 31, 2019 and the notes thereto, which are included in the Company’s final prospectus for the Company’s initial public offering filed pursuant to Rule 424(b)(4) under the Securities Act of 1933, as amended, with the SEC on July 17, 2020. Reverse Stock Split On July 8, 2020, the Company’s board of directors approved an amendment to the Company’s certificate of incorporation to effect a 1-for-6.5806 reverse split of its common stock and convertible preferred stock. The par values of the common and convertible preferred stock were not adjusted as a result of the reverse stock split. All authorized, issued and outstanding common stock, convertible preferred stock, stock options, warrants, and related per share amounts contained in the condensed consolidated financial statements have been retroactively adjusted to reflect this reverse stock split for all periods presented. The reverse stock split was effected on July 9, 2020. Use of Estimates The preparation of the condensed consolidated financial statements in conformity with U.S. GAAP requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities and disclosure of contingent assets and liabilities at the date of the condensed consolidated financial statements and the reported amounts of revenues and expenses during the reporting periods. On an ongoing basis, management evaluates its estimates, including those related to the estimated useful lives of long-lived assets, clinical trial accruals, fair value of assets and liabilities, Series B convertible preferred stock warrant liability, term loan compound derivative liability, term loan, valuation of the Company’s common stock, income taxes and stock-based compensation. Management bases its estimates on historical experience and on various other market-specific and relevant assumptions that management believes to be reasonable under the circumstances. Actual results could differ from those estimates. Cash and Cash Equivalents The Company holds its cash and cash equivalents in checking and money market accounts. The Company considers all highly liquid investments with original maturities of three months or less from the date of purchase to be cash equivalents. Cash equivalents consist primarily of amounts invested in money market accounts and are stated at fair value. Concentration of Credit Risk and Other Risks and Uncertainties Financial instruments that potentially subject the Company to a concentration of credit risk consist primarily of cash and cash equivalents. The Company maintains deposits in federally insured financial institutions in excess of federally insured limits, and invests in money market funds. The Company is exposed to credit risk in the event of default by the financial institutions holding its cash and cash equivalents. The Company has not experienced any losses on its deposits of cash and cash equivalents. The Company’s future results of operations involve a number of other risks and uncertainties. Factors that could affect the Company’s future operating results and cause actual results to vary materially from expectations include, but are not limited to, uncertainty of results of clinical trials and reaching milestones, uncertainty of regulatory approval of the Company’s potential product candidates, uncertainty of market acceptance of the Company’s product candidates, competition from substitute products and larger companies, securing and protecting proprietary technology, strategic relationships and dependence on key individuals or sole-source suppliers. The Company’s product candidates require approvals from the U.S. Food and Drug Administration, or FDA, and comparable foreign regulatory agencies prior to commercial sales in their respective jurisdictions. There can be no assurance that any product candidates will receive the necessary approvals. If the Company was denied approval, approval was delayed or the Company was unable to maintain approval for any product candidate, it could have a materially adverse impact on the Company. Property and Equipment Property and equipment are stated at cost less accumulated depreciation. Depreciation of property and equipment is provided using the straight-line method over the estimated useful lives of the assets (Note 4). Upon sale or retirement of assets, the cost and related accumulated depreciation or amortization are removed from the condensed consolidated balance sheet and the resulting gain or loss is reflected in the condensed consolidated statement of operations and comprehensive loss. Maintenance and repairs are charged to the condensed consolidated statement of operations and comprehensive loss as incurred. Deferred Offering Costs The Company capitalizes certain legal, professional accounting and other third-party fees that are directly associated with in-process equity financings as deferred offering costs until such financings are consummated. After consummation of the equity financing, these costs are recorded in stockholders’ deficit as a reduction of additional paid-in capital generated as a result of the offering. Should the in-process equity financing be abandoned, the deferred offering costs will be expensed immediately as a charge to operating expenses in the condensed consolidated statements of operations and comprehensive loss. As of June 30, 2020, $2.4 million of deferred offering costs were capitalized and recorded as other assets on the condensed consolidated balance sheet. The deferred offering costs were reclassified to additional paid-in capital upon the consummation of the Company's initial public offering in July 2020. See Note 12 to these condensed consolidated financial statements for additional details. Impairment of Long-Lived Assets The Company reviews property and equipment for impairment whenever events or changes in circumstances indicate that the carrying amount of an asset may not be recoverable. Recoverability is measured by comparison of the carrying amount to the future undiscounted net cash flows which the asset or asset group are expected to generate. If such assets are considered to be impaired, the impairment to be recognized is measured as the amount by which the carrying amount of the assets exceeds its fair value. Fair value is determined using various valuation techniques including discounted cash flow models, quoted market values and third-party independent appraisals, as considered necessary. There were no impairment charges recognized in the three and six months ended June 30, 2020 and 2019. Fair Value of Financial Instruments The Company applies fair value accounting for all financial assets and liabilities and nonfinancial assets and liabilities that are required to be recognized or disclosed at fair value in the condensed consolidated financial statements. The Company defines fair value as the price that would be received from selling an asset or paid to transfer a liability in an orderly transaction between market participants at the measurement date. Where observable prices or inputs are not available valuation models are applied. These valuation techniques involve some level of management estimation and judgment, the degree of which is dependent on the price transparency for the instruments or market and the instruments’ complexity. The Company’s financial instruments consist of cash and cash equivalents, receivables due from related-party, accounts payable, the term loan compound derivative liability and the Series B convertible preferred stock warrant liability. The term loan compound derivative liability and the Series B convertible preferred stock warrant liability are re-measured at the end of every period and carried at fair value (Note 3). The recorded value of the Company’s receivables due from related-party and accounts payable approximates its current fair value due to the relatively short-term nature of these items. Term Loan The Company accounts for the Loan and Security Agreement, dated as of December 20, 2019, as amended, with Silicon Valley Bank, or SVB, and WestRiver Innovation Lending Fund VIII, LP, or WestRiver, collectively as lenders, and SVB, as administrative agent and collateral agent, as a liability measured at net proceeds less debt discount and is accreted to the face value of the term loan over its expected term using the effective interest method. The Company considers whether there are any embedded features in its debt instruments that require bifurcation and separate accounting as derivative financial instruments pursuant to Accounting Standards Codification, or ASC, Topic 815, Derivatives and Hedging Convertible Preferred Stock The Company records convertible preferred stock net of issuance costs on the dates of issuance, which represents the carrying value. In the event of a change of control of the Company, proceeds will be distributed in accordance with the liquidation preferences set forth in its organization documents unless the holders of convertible preferred stock have converted their convertible preferred stock into common stock. Convertible preferred stock are classified outside of stockholders’ deficit on the accompanying condensed consolidated balance sheets as events triggering the liquidation preferences are not solely within the Company’s control. The Company has elected not to adjust the carrying values of the convertible preferred stock to the liquidation preferences of such shares because of the uncertainty of whether or when such an event would occur. Upon the consummation of the Company’s initial public offering in July 2020, all shares of convertible preferred stock outstanding and accrued cumulative dividends were automatically converted into 23,934,533 shares of common stock. See Note 12 to these condensed consolidated financial statements for additional details. Series B Convertible Preferred Stock Warrant Liability The Company has issued freestanding warrants to purchase its Series B convertible preferred stock. Freestanding warrants for the Company’s convertible preferred stock that are classified outside of permanent equity are recorded at fair value, and are subject to re-measurement at the end of every period until the earlier of the exercise of the warrants or the completion of a liquidation event, including the completion of an initial public offering. Upon exercise, the Series B convertible preferred stock warrant liability would be reclassified to additional paid-in capital, with any change in fair value recognized as a component of other expense, net. Following the Company’s initial public offering, the warrants were automatically converted to warrants to purchase shares of common stock. See Note 5 to these condensed consolidated financial statements for additional details. Revenue Recognition To date, the Company has derived revenue from providing research and development services on a time and materials basis to a related-party. The Company recognizes such revenues over time as services are delivered, and invoices the customer as the work is incurred in arrears. Effective January 1, 2018, the Company adopted ASC Topic 606, Revenue from Contracts with Customers To determine revenue recognition for arrangements that the Company determines are within the scope of Topic 606, the Company performs the following five steps: (i) identify the contract(s) with a customer; (ii) identify the performance obligations in the contract; (iii) determine the transaction price; (iv) allocate the transaction price to the performance obligations in the contract; and (v) recognize revenue when (or as) the Company satisfies a performance obligation. As part of the Company’s consideration as to whether the Company has entered into a contract with a customer, it considers whether it is probable that it will collect the consideration it is entitled to in exchange for the goods and services it transfers to the customer. At contract inception, the Company assesses the goods or services promised within each contract that falls under the scope of Topic 606, determines those that are performance obligations, and assesses whether each promised good or service is distinct. The Company then recognizes as revenue the amount of the transaction price that is allocated to the respective performance obligation when (or as) the performance obligation is satisfied. Cost of Services for Related-Party Revenue The Company incurs costs associated with related-party services including direct labor and associated employee benefits, laboratory supplies, and other expenses. These costs are recorded in cost of services for related-party revenue as a component of total operating expenses in the accompanying condensed consolidated statements of operations and comprehensive loss. Research and Development Costs Research and development costs are expensed as incurred and consist primarily of salaries and benefits, stock-based compensation expense, lab supplies and facility costs, as well as fees paid to nonemployees and entities that conduct certain research and development activities on behalf of the Company and expenses incurred in connection with license agreements (Note 8). Nonrefundable advance payments for goods or services to be received in the future for use in research and development activities are capitalized and recorded in prepaid expenses and other current assets, and then expensed as the related goods are delivered or the services are performed. Clinical and Manufacturing Accruals The Company records accruals for estimated costs of research, preclinical studies and clinical trials, and manufacturing development, which are a significant component of research and development expenses. A substantial portion of the Company’s ongoing research and development activities are conducted by third-party service providers, including contract research organizations, or CROs, and contract manufacturing organizations, or CMOs. The Company’s contracts with CROs generally include pass-through fees such as regulatory expenses, investigator fees, travel costs and other miscellaneous costs, including shipping and printing fees. The financial terms of these contracts are subject to negotiations, which vary from contract to contract and may result in payment flows that do not match the periods over which materials or services are provided to the Company under such contracts. The Company accrues the costs incurred under agreements with these third parties based on estimates of actual work completed in accordance with the respective agreements. The Company determines the estimated costs through discussions with internal personnel and external service providers as to the progress or stage of completion of the services and the agreed-upon fees to be paid for such services. The Company makes significant judgments and estimates in determining the accrual balance at the end of each reporting period. As actual costs become known, the Company adjusts its accruals. Although the Company does not expect its estimates to be materially different from amounts actually incurred, the Company’s understanding of the status and timing of services performed relative to the actual status and timing of services performed may vary and could result in the Company reporting amounts that are too high or too low in any particular period. To assist in its estimates the Company relies upon the receipt of timely and accurate reporting from its clinical and non-clinical studies and other third-party vendors. Through June 30, 2020, there have been no material differences from the Company’s accrued estimated expenses to the actual clinical trial expenses. However, variations in the assumptions used to estimate accruals, including, but not limited to, the number of patients enrolled, the rate of patient enrollment, and the actual services performed, and related costs may vary from the Company’s estimates, resulting in adjustments to clinical trial expense in future periods. Changes in these estimates that result in material changes to the Company’s accruals could materially affect its financial position and results of operations. Stock-based Compensation Expense The Company accounts for stock-based compensation by measuring and recognizing compensation expense for all stock-based payments made to employees, directors and non-employees based on estimated grant-date fair values. The Company uses the straight-line method to allocate compensation expense to reporting periods over each optionee’s requisite service period, which is generally the vesting period, and estimates the fair value of stock-based awards to employees and directors using the Black-Scholes option-pricing model. The Black-Scholes model requires the input of subjective assumptions, including expected volatility, expected dividend yield, expected term, risk-free rate of return and the estimated fair value of the underlying common stock on the date of grant. The Company accounts for the effect of forfeitures as they occur. Segment Reporting The Company manages its operations as a single operating segment for the purposes of assessing performance and making operating decisions. Foreign Currency Transactions The functional currency of the Company’s operation and each of its subsidiaries is U.S. dollars. All assets and liabilities denominated in a foreign currency are translated into U.S. dollars at the exchange rate prevailing on the balance sheet date. Expenses are translated at the average exchange rates prevailing during the applicable period. Foreign currency transaction gains and losses are included in the consolidated statement of operations and comprehensive loss and recorded in other expense, net, and were immaterial for the three and six months ended June 30, 2020 and 2019, respectively. Income Taxes The Company accounts for income taxes under the asset and liability method, which requires the recognition of deferred tax assets and liabilities for the expected future tax consequences of events that have been included in the condensed consolidated financial statements. Under this method, deferred tax assets and liabilities are determined on the basis of the differences between the condensed consolidated financial statement carrying amounts and tax bases of assets and liabilities using enacted tax rates in effect for the period in which the temporary differences are expected to reverse. The effect of a change in tax rates on deferred tax assets and liabilities is recognized in the condensed consolidated statements of operations and comprehensive loss in the period that includes the enactment date. The Company recognizes deferred tax assets to the extent that it believes these assets are more likely than not to be realized. In making such a determination, the Company considers all available positive and negative evidence, including future reversals of existing taxable temporary differences, projected future taxable income, tax-planning strategies and results of recent operations. If the Company determines that it would be able to realize its deferred tax assets in the future in excess of their net recorded amount, it would make an adjustment to the deferred tax asset valuation allowance, which would reduce the provision for income taxes. The Company recognizes benefits of uncertain tax positions if it is more likely than not that such positions will be sustained upon examination based solely on their technical merits, as the largest amount of benefit that is more likely than not to be realized upon the ultimate settlement. The Company’s policy is to recognize interest and penalties related to the underpayment of income taxes as a component of income tax expense or benefit. Comprehensive Loss Comprehensive loss is equal to net loss for all periods presented. Net Loss Per Share Attributable to Common Stockholders Basic net loss per share is calculated by dividing the net loss attributable to common stockholders by the weighted-average number of shares of common stock outstanding during the period, without consideration for common stock equivalents. Diluted net loss per share is the same as basic net loss per share, since the effects of potentially dilutive securities are antidilutive given the net loss for each period presented. The Company applies the two-class method to compute basic and diluted net loss per share when it has issued shares that meet the definition of participating securities. The two-class method determines net loss per share for each class of common stock and participating securities according to dividends declared or accumulated and participation rights in undistributed earnings. The two-class method requires net loss available to common stockholders for the period to be allocated between common and participating securities based upon their respective rights to share in the earnings as if all net loss for the period had been distributed. The Company’s convertible preferred stock participate in any dividends declared by the Company and are therefore considered to be participating securities. The participating securities are not required to participate in the losses of the Company, and therefore during periods of loss there is no allocation required under the two-class method. Recent Accounting Pronouncements In February 2016, the FASB issued ASU No. 2016-02 (Topic 842), Leases In December 2019, the FASB issued ASU No. 2019-12, Income Taxes (Topic 740): Simplifying the Accounting for Income Taxes, which is intended to simplify various aspects related to accounting for income taxes. The pronouncement is effective for fiscal years, and for interim periods within those fiscal years, beginning after December 15, 2021. ASU 2019-12 is effective for the Company beginning January 1, 2022. Early adoption is permitted. The Company is currently in the process of evaluating the effects of the adoption of this guidance on the Company’s financial statements and does not expect it to have a material impact on its condensed consolidated financial statements. New Accounting Pronouncements Recently Adopted In June 2016, the FASB issued ASU No. 2016-13, Financial Instruments-Credit Losses (Topic 326), which requires entities to measure all expected credit losses for financial assets held at the reporting date based on historical experience, current conditions, and reasonable and supportable forecasts. This replaces the existing incurred loss model and is applicable to the measurement of credit losses on financial assets measured at amortized cost. The Company early adopted this guidance on January 1, 2020. The adoption of this guidance did not have a material impact on the Company’s condensed consolidated financial statements. In September 2018, the FASB issued ASU No. 2018-13, Fair Value Measurement (Topic 820): Disclosure Framework—Changes to the Disclosure Requirements for Fair Value Measurement. The FASB issued final guidance that eliminates, adds and modifies certain disclosure requirements for fair value measurements as part of its disclosure framework project. Under the ASU, entities will no longer be required to disclose the amount of transfers between Level 1 and Level 2 of the fair value hierarchy. Public companies will be required to disclose changes in unrealized gains and losses for the period included in other comprehensive income for recurring Level 3 fair value measurements held at the end of the reporting period and the range and weighted average used to develop significant unobservable inputs for Level 3 fair value measurements. ASU 2018-13 is effective for public business entities for annual reporting periods, and interim periods within those annual periods, beginning after December 15, 2019, with early adoption permitted. The Company adopted this guidance on January 1, 2020. The adoption of ASU 2018-13 did not have a material impact on its condensed consolidated financial statements. |
Fair Value of Financial Instrum
Fair Value of Financial Instruments | 6 Months Ended |
Jun. 30, 2020 | |
Fair Value Disclosures [Abstract] | |
FAIR VALUE OF FINANCIAL INSTRUMENTS | (3) FAIR VALUE OF FINANCIAL INSTRUMENTS The fair value of the Company’s financial assets and liabilities are determined in accordance with the fair value hierarchy established in ASC Topic 820, Fair Value Measurements and Disclosures. ASC Topic 820 defines fair value as the exchange price that would be received for an asset or paid to transfer a liability (an exit price) in the principal or most advantageous market for the asset or liability in an orderly transaction between market participants on the measurement date. The fair value hierarchy of ASC Topic 820 requires an entity to maximize the use of observable inputs when measuring fair value and classifies those inputs into three levels: Level 1—Observable inputs, such as quoted prices in active markets Level 2—Inputs, other than the quoted prices in active markets, which are observable either directly or indirectly such as quoted prices for similar assets or liabilities; quoted prices in markets that are not active; or other inputs that are observable or can be corroborated by observable market data for substantially the full term of the instrument’s anticipated life Level 3—Unobservable inputs in which there is little or no market data, which require the reporting entity to develop its own assumptions The Company’s financial instruments consist of cash and cash equivalents, receivables due from related-party, accounts payable, the term loan compound derivative liability and the Series B convertible preferred stock warrant liability. Cash and cash equivalents are reported at their respective fair values on the Company’s condensed consolidated balance sheets. Where quoted prices are available in an active market, securities are classified as Level 1. The Company classifies money market funds as Level 1. When quoted market prices are not available for the specific security, then the Company estimates fair value by using quoted prices for identical or similar instruments in markets that are not active and model-based valuation techniques for which all significant inputs are observable in the market or can be corroborated by observable market data for substantially the full term of the assets. Where applicable, these models project future cash flows and discount the future amounts to a present value using market-based observable inputs obtained from various third-party data providers, including but not limited to benchmark yields, reported trades and broker/dealer quotes. Where applicable the market approach utilizes prices and information from market transactions for similar or identical assets. The Company measures its Series B convertible preferred stock warrant liability and term loan compound derivative liability at fair value on a recurring basis and these are classified as Level 3 liabilities. The fair value of the Series B convertible preferred stock warrant liability was determined using an option-pricing model. The Company calculated the fair value of the term loan compound derivative liability by computing the difference between the fair value of the term loan with the compound derivative using the “with and without” method under the income approach, and the fair value of the term loan without the compound derivative. The valuation methodology and underlying assumptions are discussed further in Note 5. The following table sets forth the Company’s financial liabilities that are measured at fair value on a recurring basis by level within the fair value hierarchy (in thousands): As of June 30, 2020 Level 1 Level 2 Level 3 Fair Value Financial assets Cash equivalents Money market funds $ 90,110 — — $ 90,110 Financial liabilities Non-current liabilities Compound derivative liability $ — — 64 $ 64 Warrant liability $ — — 756 $ 756 As of December 31, 2019 Level 1 Level 2 Level 3 Fair Value Financial liabilities Non-current liabilities Compound derivative liability $ — — 51 $ 51 Warrant liability $ — — 361 $ 361 The following table is a reconciliation of all financial liabilities measured at fair value using Level 3 unobservable inputs (in thousands): Compound Warrant Derivative Liability Liability Fair value at December 31, 2019 $ 361 $ 51 Change in fair value 395 13 Fair value at June 30, 2020 $ 756 $ 64 The Company did not have any outstanding financial assets or liabilities to be re-measured on a recurring basis as of June 30, 2019. There were no transfers of assets or liabilities between the fair value measurement levels during the six months ended June 30, 2020 and the year ended December 31, 2019. The carrying values of the Company’s financial instruments, such as accounts payable and accrued expenses and other current liabilities, approximate fair value due to the short-term nature of these items. Term Loan The estimated fair value of the Term Loan was $5.8 million as of June 30, 2020, which approximates the carrying value and is classified as Level 3. The Company utilized a market yield analysis and income approach to estimate a value for the Term Loan. The key valuation assumptions used consist of the discount rate of 16.5% and the probability of the occurrence of a change in control event of 10.0%. |
Balance Sheet Components
Balance Sheet Components | 6 Months Ended |
Jun. 30, 2020 | |
Balance Sheet Related Disclosures [Abstract] | |
BALANCE SHEET COMPONENTS | (4) BALANCE SHEET COMPONENTS Property and Equipment, Net The following table presents the components of property and equipment, net as of June 30, 2020 and December 31, 2019 (in thousands): June 30, December 31, 2020 2019 Computer hardware and software $ 61 $ 146 Machinery and equipment 41 1,698 Furniture and fixtures 9 36 Leasehold improvements 18 429 129 2,309 Less: accumulated depreciation and amortization (92 ) (1,449 ) Total property and equipment, net $ 37 $ 860 Depreciation and amortization expense was $0.1 million for the three months ended June 30, 2020 and 2019, and $0.2 million for the six months ended June 30, 2020 and 2019. At June 30, 2020, certain lab equipment and other assets for an aggregated net book value of $0.6 million relating to the asset transfer with Tallac Therapeutics, Inc. (formerly known as Tollnine, Inc., or Tollnine), or Tallac Therapeutics, met the criteria as assets held for sale. Those assets are reported at the lower of carrying value or fair value less costs to sell. Accrued Expenses and Other Current Liabilities The following table presents the components of accrued expenses and other current liabilities as of June 30, 2020 and December 31, 2019 (in thousands): June 30, December 31, 2020 2019 Accrued professional fees $ 2,219 $ 122 Accrued compensation 671 924 Accrued clinical and nonclinical study costs 800 — Accrued contract manufacturing 149 53 Other 301 137 Total accrued expenses and other current liabilities $ 4,140 $ 1,236 |
Term Loan
Term Loan | 6 Months Ended |
Jun. 30, 2020 | |
Debt Disclosure [Abstract] | |
TERM LOAN | (5) TERM LOAN The Company’s wholly-owned subsidiaries Alexo Therapeutics International and Sirpant Therapeutics, as borrowers, entered into a Loan and Security Agreement, or the Loan Agreement, dated as of December 20, 2019, with SVB and WestRiver, collectively as lenders, and SVB, as administrative agent and collateral agent. As a result of the internal reorganization, in May 2020 the Company entered into a Joinder and First Amendment to the Loan and Security Agreement, or the Joinder Amendment, and Amended and Restated Warrants to Purchase Stock, or the Amended Warrants. The purpose for entering into the Joinder Amendment was to add the newly established ALX Oncology Holdings Inc. as additional borrower to the Term Loan. Concurrently, the Company modified the Amended Warrants to change the issuer from ALX Oncology Limited to ALX Oncology Holdings Inc. The Company accounted for the First Amendment to the Loan and Security Agreement as a modification. The Loan Agreement provides for term loans in an aggregate principal amount of up to $10.0 million funded in two tranches, subject to the satisfaction of a certain milestone. The first tranche, in the amount of $6.0 million, was funded on the closing date of the Loan Agreement in December 2019. A second tranche of $4.0 million was available on or before March 31, 2020, upon the Company’s achievement of an equity financing resulting in net cash proceeds in an amount of at least $30.0 million to the Company. The Company elected not to draw down on the second tranche, which is no longer available. The loans under the Loan Agreement bear interest at a floating per annum interest rate equal to the greater of 7.0% or 2.0% plus the prime rate as reported in The Wall Street Journal. The Wall Street Journal prime rate was 3.25% as of June 30, 2020. Therefore, the rate applicable to the Company as of June 30, 2020 was 7.0%. The Company is required to make interest-only payments for the first 12 months after the closing of the Loan Agreement, followed by consecutive equal monthly payments of principal and interest commencing on January 1, 2021 and continuing through the maturity date of September 1, 2022. The Loan Agreement also provides for a final payment equal to 6.0% multiplied by the aggregate principal amount of the term loans funded, which is due on the maturity date, upon the acceleration of the term loans, or upon prepayment of the term loans. If the Company elects to prepay the term loans, there is also a prepayment fee of between 1.0% and 3.0% of the principal amount being prepaid depending on the timing and circumstances of prepayment. In conjunction with the Loan Agreement, the Company has issued warrants to purchase 61,292 Series B convertible preferred stock to SVB and WestRiver with an exercise price of $9.4972 per share. Following the Company’s initial public offering, these warrants were automatically converted to warrants to purchase 61,292 shares of common stock at an exercise price of $9.4972 per share. The estimated fair value of the warrants at the date of issuance was approximately $0.4 million. The fair value of the Series B convertible preferred stock warrant liability was determined using the Black-Scholes option-pricing model. As of June 30, 2020, the various assumptions used in the option-pricing model were time to liquidity of 2.0 to 9.5 years, volatility of 99.9% and risk-free rate of 0.6%. It was recorded at its fair value at inception and is being re-measured at each financial reporting period with any changes in fair value being recognized as a component of other expense, net in the accompanying condensed consolidated statement of operations and comprehensive loss. As of June 30, 2020, the fair value of the Series B convertible preferred stock warrant liability was approximately $0.8 million and was recorded in other non-current liabilities on the condensed consolidated balance sheets. The loans under the Loan Agreement are secured by substantially all of the Company’s assets, except the Company’s intellectual property, which is the subject of a negative pledge. The Company determined that certain loan features were embedded derivatives requiring bifurcation and separate accounting. Those embedded derivatives were bundled together as a single, compound embedded derivative and then bifurcated and accounted for separately from the host contract. The Company recorded a term loan compound derivative liability of approximately $51,000 which will be marked-to-market in future periods. The Company calculated the fair value of the compound derivative by computing the difference between the fair value of the term loan with the compound derivative using the “with and without” method under the income approach, and the fair value of the term loan without the compound derivative. The Company calculated the fair values using a probability-weighted discounted cash flow analysis. The key valuation assumptions used consist of the discount rate and the probability of the occurrence of a change in control event. The term loan compound derivative liability is being re-measured at each financial reporting period with any changes in fair value being recognized as a component of other expense, net in the condensed consolidated statement of operations and comprehensive loss. As of June 30, 2020, the fair value of the compound derivative liability was approximately $64,000 and was recorded in other non-current liabilities on the condensed consolidated balance sheets. The fair value of Series B convertible preferred stock warrant liability at issuance, fair value of embedded derivatives which were bifurcated and other debt issuance costs have been treated as debt discounts on the Company’s condensed consolidated balance sheet and together with the final payment are being amortized to interest expense throughout the life of the term loan using the effective interest rate method. As of June 30, 2020, there were unamortized issuance costs and debt discounts of $0.4 million, which were recorded as a direct deduction from the term loan on the condensed consolidated balance sheet. Interest expense for the term loan was $0.2 million and $0.4 million for the three months and six months ended June 30, 2020, respectively. The following table presents future payments of principal and interest as of June 30, 2020 is as follows (in thousands): June 30, 2020 2020 (remaining six months) $ 214 2021 3,743 2022 3,007 6,964 Less: amount representing interest $ (604 ) Less: amount representing final payment (360 ) Term loan, gross 6,000 Less: unamortized issuance costs and debt discounts (358 ) Less: current portion (1,714 ) Non-current portion of term loan $ 3,928 |
Capital Structure
Capital Structure | 6 Months Ended |
Jun. 30, 2020 | |
Equity [Abstract] | |
CAPITAL STRUCTURE | (6) CAPITAL STRUCTURE Common Stock Common stock reserved for future issuance, on an as if converted basis, as of June 30, 2020 and December 31, 2019, consists of the following and have been adjusted for the 1-for-6.5806 reverse split: June 30, December 31, 2020 2019 Convertible preferred stock issued and outstanding 21,369,774 10,313,808 Stock options issued and outstanding 3,874,815 1,183,745 Stock options authorized for future issuance 111,869 566,900 Warrants issued and outstanding 61,292 61,292 Warrants authorized for future issuance — 30,646 Total 25,417,750 12,156,391 Convertible Preferred Stock As of June 30, 2020 and December 31, 2019, the Company’s convertible preferred stock consisted of the following and have been adjusted for the 1-for-6.5806 reverse split (in thousands, except share amounts): June 30, 2020 Shares Aggregate Authorized Issued And Net Liquidation Shares Outstanding Proceeds (1) Preference Shares designated as: Series A convertible preferred stock 9,297,100 9,297,081 $ 60,933 $ 75,412 Series B convertible preferred stock 1,108,675 1,016,727 9,430 10,304 Series C convertible preferred stock 11,055,981 11,055,966 104,680 107,504 Total 21,461,756 21,369,774 $ 175,043 $ 193,220 December 31, 2019 Shares Aggregate Authorized Issued And Net Liquidation Shares Outstanding Proceeds (1) Preference Shares designated as: Series A convertible preferred stock 9,421,633 9,297,081 $ 60,933 $ 73,571 Series B convertible preferred stock 2,145,370 1,016,727 9,430 10,014 Total 11,567,003 10,313,808 $ 70,363 $ 83,585 (1) Net proceeds are gross proceeds from the offerings net of issuance costs. |
Stock-Based Compensation
Stock-Based Compensation | 6 Months Ended |
Jun. 30, 2020 | |
Disclosure Of Compensation Related Costs Sharebased Payments [Abstract] | |
STOCK-BASED COMPENSATION | (7) STOCK-BASED COMPENSATION 2020 Amended and Restated Equity Incentive Plan On April 1, 2020, the board of directors approved a new equity incentive plan, or the 2020 Equity Incentive Plan, that replaced the 2015 Share Award Scheme. In July 2020, the Company adopted the Amended and Restated 2020 Equity Incentive Plan, or the 2020 Plan. The 2020 Plan replaced the Company’s 2020 Equity Incentive Plan and a total of 7,874,862 shares were reserved under the 2020 Plan. Stock Option Modification In connection with the transfer of employees to Tallac Therapeutics, Dr. Hong Wan, the Company’s former Chief Scientific Officer, and eight of the Company’s employees, or Transferred Employees, terminated their employment with the Company effective as of June 30, 2020 and became employees of Tallac Therapeutics effective as of July 1, 2020. The options to purchase shares of the Company’s common stock that were previously granted to the Transferred Employees will continue to vest and be exercisable subject to the Transferred Employees remaining service providers under the original terms of the award. See Note 12 to these condensed consolidated financial statements for additional details. The Company evaluated the change in status from an employee to a consultant in accordance with ASC 718. While the Company concluded that the change in status did not affect the vesting condition, or the classification of the initial awards, the significant reduction in the level of services that the grantees were expected to provide under the original awards as compared to the level of services expected under the Tallac Services Agreement will no longer meet the substantive service condition requirements and therefore the compensation cost for the unvested awards was recognized immediately with no future service requirement. The Company recorded $2.3 million in stock-based compensation expenses related to the modification for the three months period ended June 30, 2020. Stock-based Compensation Expense Total stock-based compensation expense recognized in the condensed consolidated statements of operations and comprehensive loss was as follows (in thousands): Three Months Ended June 30, Six Months Ended June 30, 2020 2019 2020 2019 Research and development $ 2,284 $ 19 $ 2,367 $ 54 General and administrative 569 7 637 14 Cost of services for related-party revenue — 34 — 68 $ 2,853 $ 60 $ 3,004 $ 136 |
License Agreement
License Agreement | 6 Months Ended |
Jun. 30, 2020 | |
Organization Consolidation And Presentation Of Financial Statements [Abstract] | |
LICENSE AGREEMENT | (8) LICENSE AGREEMENT Exclusive (Equity) Agreement with The Board of Trustees of the Leland Stanford Junior University In March 2015, the Company entered into a license agreement, or the Stanford Agreement, with the Board of Trustees of the Leland Stanford Junior University, or Stanford, under which the Company obtained a worldwide, royalty-bearing, sublicensable license under certain patents relating to the Company’s current product candidates, to develop, manufacture and commercialize products for use in certain licensed fields, the scope of which would include the application of the licensed intellectual property in oncology. The license granted to the Company in the Stanford Agreement includes an exclusive grant, subject to certain pre-existing non-exclusive or exclusive rights that Stanford retained for grant to third parties with respect to certain categories of the licensed patents in certain fields of use and retained rights by Stanford and all other nonprofit institutions to use and practice the licensed patents and technology for internal research and other nonprofit purposes. The license granted to the Company in the Stanford Agreement also includes non-exclusive grants to certain Stanford patents. In consideration for the rights granted to the Company under the Stanford Agreement, the Company paid Stanford a nonrefundable license royalty and reimbursed Stanford for past patent expenses, together totaling less than $0.1 million, and granted Stanford a specified number of shares of common stock of the Company. In addition, the Company is obligated to pay Stanford ongoing patent expenses and an annual license maintenance fee, which are nominal and will be creditable against any royalties payable to Stanford in the applicable year. The Company is required to make milestone payments up to an aggregate of $5.0 million in respect of a specified number of licensed products that successfully satisfy certain clinical and regulatory milestones. No milestone payments have been made through June 30, 2020. The Company also agreed to pay Stanford tiered royalties on a specified percentage of net sales made by the Company, its affiliates and its sublicensees of licensed products at rates ranging within low single-digit percentages, subject to certain reductions and offsets. The license, on a licensed product-by-licensed product and country-by-country basis, shall become royalty-free and fully paid-up upon the later of the date on which the last valid claim included in the exclusively or non-exclusively licensed patents expires and ten years after the first commercial sale of the licensed product in such country. The Company may terminate the Stanford Agreement, on a licensed product-by-licensed product basis, at any time for any reason by providing at least 60 days’ written notice to Stanford. Stanford may terminate the Stanford Agreement, if the Company is in breach of any provision of the Stanford Agreement and fails to remedy such breach within 60 days after written notice of such breach by Stanford. In addition, Stanford has the right to terminate the Stanford Agreement, on a licensed product-by-licensed product basis, if the Company is not diligently developing and commercializing such licensed product under certain conditions or if the Company fails to achieve specified development milestones for such licensed product by certain dates, subject to the Company’s extension rights. Commercial License Agreement with Selexis SA In June 2016, the Company entered into a license agreement with Selexis SA, or Selexis, under which the Company obtained a worldwide, royalty-bearing, sublicensable license under certain patents, know-how and other intellectual property, to use Selexis generated cell lines to manufacture ALX148 and to make, use and sell licensed product containing such compound in all fields of use. The rights granted under this agreement include the rights to grant sublicenses to contractors or other collaboration partners, in each case to develop production processes or manufacture licensed product containing ALX148. In consideration for the rights granted to the Company under the agreement, the Company paid Selexis a nominal one-time fee and will pay Selexis an annual maintenance fee. The Company also agreed to pay Selexis milestone payments up to an aggregate of 1.2 million Swiss Francs in respect of all licensed products developed and/or commercialized under the grant that successfully satisfies certain milestone events. The Company also agreed to pay Selexis a flat royalty of a very low single-digit percentage on net sales made by the Company, its affiliates and sublicensees of products. This royalty obligation, on a product-by-product and country-by-country basis, shall terminate and become fully paid-up upon the passing of ten years after the first commercial sale of the product in such country, or the Company’s exercise of the royalty buyout option exercisable at any time prior to the first commercial sale of a licensed product. The Company may terminate the license agreement at any time for any reason with at least 60 days’ written notice to Selexis. Either party may terminate the license agreement if the other party enters into a bankruptcy event or in the event of a material breach of the agreement (that cannot be cured or remains uncured for 60 days after the date that the defaulting party is provided with written notice of such breach). The Company’s obligations to pay royalties that are accrued or accruable will survive any termination of the agreement, and in certain circumstances the licenses granted under the agreement will terminate unless they have become fully paid up as described in the previous paragraph. Commercial Antibody Agreement with Crystal Bioscience Inc. (Now a Subsidiary of Ligand Pharmaceuticals Incorporated) In March 2017, the Company entered into an agreement with Crystal Bioscience Inc. (now a subsidiary of Ligand Pharmaceuticals Incorporated), or Crystal, under which the Company obtained an assignment of certain patents, covering certain SIRPα antibodies. Under this agreement, the Company also received a worldwide, royalty-bearing non-exclusive license, with the right to grant sublicenses through multiple tiers of sublicenses, under certain of Crystal’s background patents and know-how necessary to commercialize the rights under the assigned patents. In consideration for the rights granted to the Company under the agreement, it agreed to pay Crystal milestone payments up to $11.1 million in respect of all licensed products developed under the assigned patents, that successfully satisfy certain clinical and regulatory milestones, each milestone being paid only once for all products. The Company also agreed to pay Crystal tiered royalties on net sales made by the Company, its affiliates and sublicensees of products at rates ranging within low single-digit percentages, subject to certain potential reductions. This royalty obligation, on a product-by-product and country-by-country basis, shall terminate and become fully paid-up upon the later of the date on which the last valid claim included in the licensed patents expires and ten years after the first commercial sale of the product in such country. The Company agreed to use commercially reasonable efforts to develop and commercialize licensed products, including meeting defined development milestones by certain specified dates. The Company may terminate the agreement at any time for any reason with at least 60 days’ written notice to Crystal. Either party may terminate the agreement if the other party enters into a bankruptcy event or in the event of material breach of the agreement (that remains uncured for 60 days after the date that it is provided with written notice of such breach). The Company’s obligations to pay royalties and milestone payments which accrued pre-termination or accrue post-termination will survive any termination. |
Related-Party Transactions
Related-Party Transactions | 6 Months Ended |
Jun. 30, 2020 | |
Related Party Transactions [Abstract] | |
RELATED-PARTY TRANSACTIONS | (9) RELATED-PARTY TRANSACTIONS Related-party revenue In June 2018, the Company entered into a Research and Development Services Agreement, or Tollnine Agreement, with Tollnine, a related-party of the Company, to provide research and development services to Tollnine. The Company’s Chief Executive Officer was also the Chief Executive Officer of Tollnine until April 2020 and two of the Company’s investors are also investors in Tollnine. As such, Tollnine was deemed to be a related-party. The Tollnine Agreement has an initial term of 3 years, to be automatically renewed for additional one-year terms unless terminated by either party. The services are to be provided at a price based on the costs incurred by the Company plus a mark-up equal to 10% of such costs. The Company recognizes revenue when Tollnine, as the Company’s customer, obtains control of promised goods or services, in an amount that reflects the consideration which the Company expects to receive in exchange for those goods or services. The Company recognized related-party revenues of $0.5 million and $1.3 million for the three months ended June 30, 2020 and 2019, respectively, and $1.2 million and $2.3 million for the six months ended June 30, 2020 and 2019, respectively, under the Tollnine Agreement. Effective as of July 1, 2020, the Company terminated the Tollnine Agreement and entered into the Tallac Services Agreement with Tallac Therapeutics. See Note 12 to these condensed consolidated financial statements for additional details. Receivables due from related-party As of June 30, 2020 and December 31, 2019, the Company had outstanding related-party receivables from Tollnine of $0.5 million and $0.5 million, respectively. |
Net Loss Per Share Attributable
Net Loss Per Share Attributable to Common Stockholders | 6 Months Ended |
Jun. 30, 2020 | |
Earnings Per Share [Abstract] | |
NET LOSS PER SHARE ATTRIBUTABLE TO COMMON STOCKHOLDERS | (10) NET LOSS PER SHARE ATTRIBUTABLE TO COMMON STOCKHOLDERS The following table sets forth the computation of the basic and diluted net loss per share attributable to common stockholders (in thousands, except share and per share data): Three Months Ended June 30, Six Months Ended June 30, 2020 2019 2020 2019 Numerator: Net loss $ (11,331 ) $ (4,197 ) $ (16,785 ) $ (8,435 ) Less: cumulative preferred dividends allocated to preferred stockholders (2,641 ) (981 ) (4,624 ) (1,886 ) Net loss attributable to common stockholders $ (13,972 ) $ (5,178 ) $ (21,409 ) $ (10,321 ) Denominator: Weighted-average shares of common stock outstanding 3,164,707 3,087,355 3,157,387 3,047,924 Net loss per share attributable to common stockholders, basic and diluted $ (4.41 ) $ (1.68 ) $ (6.78 ) $ (3.39 ) Since the Company was in a loss position for all periods presented, basic net loss per share is the same as diluted net loss per share for all periods presented as the inclusion of all potential common stock outstanding would have been anti-dilutive. The following outstanding potentially dilutive securities were excluded from the computation of diluted net loss per share for the periods presented because including them would have been anti-dilutive: June 30, 2020 2019 Convertible preferred stock 21,369,774 10,313,808 Warrants to purchase convertible preferred stock 61,292 — Common stock subject to repurchase 3,908 72,714 Options issued and outstanding 3,874,815 924,043 Total 25,309,789 11,310,565 |
Commitments and Contingencies
Commitments and Contingencies | 6 Months Ended |
Jun. 30, 2020 | |
Commitments And Contingencies Disclosure [Abstract] | |
COMMITMENTS AND CONTINGENCIES | (11) COMMITMENTS AND CONTINGENCIES Guarantees and Indemnifications In the normal course of business, the Company enters into contracts and agreements that contain a variety of representations and warranties and provide for general indemnifications. The Company’s exposure under these agreements is unknown because it involves claims that may be made against the Company in the future but have not yet been made. To date, the Company has not paid any claims or been required to defend any action related to its indemnification obligations. However, the Company may record charges in the future as a result of these indemnification obligations. The Company also has indemnification obligations to its officers and directors for specified events or occurrences, subject to some limits, while they are serving at the Company’s request in such capacities. There have been no claims to date and the Company has director and officer insurance that may enable the Company to recover a portion of any amounts paid for future potential claims. The Company believes the fair value of these indemnification agreements is minimal. Accordingly, the Company has not recorded any liabilities for these agreements as of June 30, 2020. Contingencies From time to time, the Company may be a party to various claims in the normal course of business. Legal fees and other costs associated with such actions will be expensed as incurred. The Company will assess, in conjunction with its legal counsel, the need to record a liability for litigation and contingencies. Reserve estimates will be recorded when and if it is determined that a loss related matter is both probable and reasonably estimable. For the six months ended June 30, 2020 the Company had no pending or threatened litigation. Contractual Obligations and Other Commitments The following table summarizes the Company’s commitments and contractual obligations as of June 30, 2020 (in thousands): Year Ended December 31: Operating lease obligations (1) Manufacturing and service contracts (2) Term loan (3) 2020 (remaining six months) $ 273 $ 4,511 $ 214 2021 560 1,563 3,743 2022 577 298 3,007 2023 247 — — Total $ 1,657 $ 6,372 $ 6,964 (1) Payments due for the office and laboratory space in Burlingame, California under a single operating lease agreement that expires in 2023. In July 2020, the Company assigned this lease to Tallac Therapeutics, and the Company received a sublease for such premises from Tallac Therapeutics. See Note 12 to these condensed consolidated financial statements for additional details. (2) In November 2015, the Company entered into a Master Service Agreement, or the MSA, with KBI Biopharma, Inc. relating to formulation development, process development and cGMP manufacturing of ALX148 for use in clinical trials on a project basis. The MSA had an initial term of three years with successive one-year renewal periods, is cancellable upon notice and is non-exclusive. Statements of work under the MSA commit the Company to certain purchase obligations of approximately $6.1 million. In addition, the Company has commitments with a second drug product manufacturer that commits the Company to certain purchase obligations of approximately $0.3 million. These amounts are based on non-cancellable commitments and forecasts that include estimates of future market demand, quantity discounts and manufacturing efficiencies that may impact timing of purchases. (3) On December 20, 2019, the Company borrowed a loan pursuant to the Loan Agreement. See Note 5 to these condensed consolidated financial statements for additional details. The Company enters into contracts in the normal course of business with various third parties for clinical trials, preclinical research studies and testing, manufacturing and other services and products for operating purposes. These contracts generally provide for termination upon notice. Payments due upon cancellation consist only of payments for services provided or expenses incurred, including non-cancellable obligations of our service providers, up to the date of cancellation. These payments are not included in the table of contractual obligations above. Facilities In 2017, the Company entered into a lease agreement for office space for a period of five years and four months, commencing February 1, 2018 and ending May 31, 2023. Minimum rent payments under operating leases are recognized on a straight-line basis over the term of the lease including any periods of free rent. Rent expense for the three months ended June 30, 2020 and 2019 was $0.2 million. Rent expense for the six months ended June 30, 2020 and 2019 was $0.4 million. Cumulative Dividends As of June 30, 2020, there were $17.4 million of accrued cumulative dividends on the Series A, Series B and Series C convertible preferred stock, which are payable upon the occurrence of certain change of control and liquidation events and upon the conversion of such convertible preferred stock. Upon closing of the initial public offering, the accrued cumulative dividends were automatically converted into shares of common stock. See Note 12 to these condensed consolidated financial statements for additional details. |
Subsequent Events
Subsequent Events | 6 Months Ended |
Jun. 30, 2020 | |
Subsequent Events [Abstract] | |
SUBSEQUENT EVENTS | (12) SUBSEQUENT EVENTS Tallac Therapeutics As of July 1, 2020, the Company terminated the Tollnine Agreement and entered into a series of transactions with Tallac Therapeutics and Dr. Hong Wan as described below. • Entry into the Tallac Services Agreement : The Company entered into a research and development services agreement, or the Tallac Services Agreement, with Tallac Therapeutics effective as of July 1, 2020. The Tallac Services Agreement provides that Tallac Therapeutics will provide certain preclinical research services to the Company for a service fee based on the costs incurred by Tallac Therapeutics plus a mark-up equal to 10.0% of such costs. The Tallac Services Agreement has an initial term of four years and is renewed automatically for additional one year terms thereafter. • Resignation of Dr. Hong Wan and entry into Consulting Agreement : Dr. Hong Wan resigned from her position as the Company’s Chief Scientific Officer and ceased to be the Company’s employee effective as of June 30, 2020. In connection with her resignation, the Company entered into a Consulting Agreement with Dr. Hong Wan effective as of July 1, 2020. Under the Consulting Agreement, Dr. Hong Wan will serve as the Company’s Chief Science Consultant and, among other things, spend approximately 20% of her time performing activities typically performed by a consulting scientific adviser in the biotechnology industry. In exchange for such services, the options to purchase shares of the Company’s common stock that were previously granted to Dr. Hong Wan will continue to vest and be exercisable subject to Dr. Hong Wan remaining a service provider under the Consulting Agreement or the Tallac Services Agreement. The Consulting Agreement has an initial term of four years and is renewed automatically for additional one-year terms thereafter. • Transfer of employees to Tallac Therapeutics : In addition to Dr. Hong Wan, eight of the Company’s employees, or Transferred Employees, also terminated their employment with the Company effective as of June 30, 2020 and became employees of Tallac Therapeutics effective as of July 1, 2020. The options to purchase shares of the Company’s common stock that were previously granted to the Transferred Employees will continue to vest and be exercisable subject to the Transferred Employees remaining service providers under the original terms of their option awards. • Entry into Asset Transfer Agreement : ALX Oncology Inc. entered into an Asset Transfer Agreement with Tallac Therapeutics effective as of July 3, 2020, pursuant to which Tallac Therapeutics purchased certain lab equipment and other assets from ALX Oncology Inc. for a cash consideration of $0.6 million representing the aggregate net book value of such assets. In July 2020, the Company received $0.6 million cash in exchange for the transfer of such assets. On July 8, 2020, the Company also (i) assigned to Tallac Therapeutics the Company’s lease with respect to the premises located at 866 Malcolm Road, Burlingame, California, and (ii) received a sub-lease for premises from Tallac Therapeutics. Initial Public Offering In July 2020, the Company consummated its initial public offering and issued a total of 9,775,000 shares of common stock, which includes the overallotment option of 1,275,000 shares exercised by the underwriters in the initial public offering, at an offering price of $19.00 per share. In aggregate, the Company received net proceeds of approximately $172.7 million, after deducting underwriting discounts and commissions of $13.0 million and before deducting offering-related expenses. In connection with the initial public offering, the following events occurred subsequent to June 30, 2020: • • In July 2020, upon consummation of the Company’s initial public offering, total shares of common stock outstanding were 36,876,479, which includes shares of common stock outstanding as of June 30, 2020, shares of common stock issued in the initial public offering and convertible preferred stock and accrued cumulative dividends converted and reclassified into common stock; and • In July 2020, the Company’s amended and restated certificate of incorporation became effective, authorizing 1,000,000,000 shares of common stock and 100,000,000 shares of undesignated preferred stock. The table below shows, on a pro forma basis, the impact of the Company’s initial public offering on certain condensed consolidated balance sheet items as if all of the transactions occurred on June 30, 2020 (in thousands): Pro Forma June 30, 2020 June 30, 2020 Cash and cash equivalents $ 98,103 $ 270,827 Deferred offering costs 2,411 — Convertible preferred stock 175,043 — Common stock 3 37 Additional paid-in capital 5,166 351,244 Total stockholders' equity (deficit) $ (84,398 ) $ 261,714 |
Significant Accounting Polici_2
Significant Accounting Policies (Policies) | 6 Months Ended |
Jun. 30, 2020 | |
Basis of Presentation | Basis of Preparation These condensed consolidated financial statements have been prepared in accordance with accounting principles generally accepted in the United States of America, or U.S. GAAP, and the applicable rules and regulations of the U.S. Securities and Exchange Commission, or SEC, for interim reporting. |
Principles of Consolidation | Principles of Consolidation All intercompany balances and transactions have been eliminated in consolidation. |
Unaudited Condensed Consolidated Financial Statements | Unaudited Condensed Consolidated Financial Statements The condensed consolidated balance sheet as of June 30, 2020, the condensed consolidated statements of operations and comprehensive loss for the three and six months ended June 30, 2020 and 2019, the condensed consolidated statements of convertible preferred stock and stockholders' deficit for the three and six months ended June 30, 2020 and 2019, and the condensed consolidated statements of cash flows for the six months ended June 30, 2020 and 2019, are unaudited. These unaudited condensed consolidated financial statements have been prepared on the same basis as the annual consolidated financial statements and, in the opinion of management, reflect all adjustments, which include only normal recurring adjustments, necessary to present fairly the Company’s financial position as of June 30, 2020, and its results of operations for the periods presented. The results of operations for the three and six months ended June 30, 2020, are not necessarily indicative of the results to be expected for any subsequent periods, including the year ended December 31, 2020, and therefore should not be relied upon as an indicator of future results. The condensed consolidated balance sheet as of December 31, 2019 included herein was derived from the audited consolidated financial statements as of that date. The accompanying condensed consolidated financial statements and related notes should be read in conjunction with the audited consolidated financial statements for the year ended December 31, 2019 and the notes thereto, which are included in the Company’s final prospectus for the Company’s initial public offering filed pursuant to Rule 424(b)(4) under the Securities Act of 1933, as amended, with the SEC on July 17, 2020. |
Reverse Stock Split | Reverse Stock Split On July 8, 2020, the Company’s board of directors approved an amendment to the Company’s certificate of incorporation to effect a 1-for-6.5806 reverse split of its common stock and convertible preferred stock. The par values of the common and convertible preferred stock were not adjusted as a result of the reverse stock split. All authorized, issued and outstanding common stock, convertible preferred stock, stock options, warrants, and related per share amounts contained in the condensed consolidated financial statements have been retroactively adjusted to reflect this reverse stock split for all periods presented. The reverse stock split was effected on July 9, 2020. |
Use of Estimates | Use of Estimates The preparation of the condensed consolidated financial statements in conformity with U.S. GAAP requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities and disclosure of contingent assets and liabilities at the date of the condensed consolidated financial statements and the reported amounts of revenues and expenses during the reporting periods. On an ongoing basis, management evaluates its estimates, including those related to the estimated useful lives of long-lived assets, clinical trial accruals, fair value of assets and liabilities, Series B convertible preferred stock warrant liability, term loan compound derivative liability, term loan, valuation of the Company’s common stock, income taxes and stock-based compensation. Management bases its estimates on historical experience and on various other market-specific and relevant assumptions that management believes to be reasonable under the circumstances. Actual results could differ from those estimates. |
Cash and Cash Equivalents | Cash and Cash Equivalents The Company holds its cash and cash equivalents in checking and money market accounts. The Company considers all highly liquid investments with original maturities of three months or less from the date of purchase to be cash equivalents. Cash equivalents consist primarily of amounts invested in money market accounts and are stated at fair value. |
Concentration of Credit Risk and Other Risks and Uncertainties | Concentration of Credit Risk and Other Risks and Uncertainties Financial instruments that potentially subject the Company to a concentration of credit risk consist primarily of cash and cash equivalents. The Company maintains deposits in federally insured financial institutions in excess of federally insured limits, and invests in money market funds. The Company is exposed to credit risk in the event of default by the financial institutions holding its cash and cash equivalents. The Company has not experienced any losses on its deposits of cash and cash equivalents. The Company’s future results of operations involve a number of other risks and uncertainties. Factors that could affect the Company’s future operating results and cause actual results to vary materially from expectations include, but are not limited to, uncertainty of results of clinical trials and reaching milestones, uncertainty of regulatory approval of the Company’s potential product candidates, uncertainty of market acceptance of the Company’s product candidates, competition from substitute products and larger companies, securing and protecting proprietary technology, strategic relationships and dependence on key individuals or sole-source suppliers. The Company’s product candidates require approvals from the U.S. Food and Drug Administration, or FDA, and comparable foreign regulatory agencies prior to commercial sales in their respective jurisdictions. There can be no assurance that any product candidates will receive the necessary approvals. If the Company was denied approval, approval was delayed or the Company was unable to maintain approval for any product candidate, it could have a materially adverse impact on the Company. |
Property and Equipment | Property and Equipment Property and equipment are stated at cost less accumulated depreciation. Depreciation of property and equipment is provided using the straight-line method over the estimated useful lives of the assets (Note 4). Upon sale or retirement of assets, the cost and related accumulated depreciation or amortization are removed from the condensed consolidated balance sheet and the resulting gain or loss is reflected in the condensed consolidated statement of operations and comprehensive loss. Maintenance and repairs are charged to the condensed consolidated statement of operations and comprehensive loss as incurred. |
Deferred Offering Costs | Deferred Offering Costs The Company capitalizes certain legal, professional accounting and other third-party fees that are directly associated with in-process equity financings as deferred offering costs until such financings are consummated. After consummation of the equity financing, these costs are recorded in stockholders’ deficit as a reduction of additional paid-in capital generated as a result of the offering. Should the in-process equity financing be abandoned, the deferred offering costs will be expensed immediately as a charge to operating expenses in the condensed consolidated statements of operations and comprehensive loss. As of June 30, 2020, $2.4 million of deferred offering costs were capitalized and recorded as other assets on the condensed consolidated balance sheet. The deferred offering costs were reclassified to additional paid-in capital upon the consummation of the Company's initial public offering in July 2020. See Note 12 to these condensed consolidated financial statements for additional details. |
Impairment of Long-Lived Assets | Impairment of Long-Lived Assets |
Fair Value of Financial Instruments | Fair Value of Financial Instruments The Company applies fair value accounting for all financial assets and liabilities and nonfinancial assets and liabilities that are required to be recognized or disclosed at fair value in the condensed consolidated financial statements. The Company defines fair value as the price that would be received from selling an asset or paid to transfer a liability in an orderly transaction between market participants at the measurement date. Where observable prices or inputs are not available valuation models are applied. These valuation techniques involve some level of management estimation and judgment, the degree of which is dependent on the price transparency for the instruments or market and the instruments’ complexity. The Company’s financial instruments consist of cash and cash equivalents, receivables due from related-party, accounts payable, the term loan compound derivative liability and the Series B convertible preferred stock warrant liability. The term loan compound derivative liability and the Series B convertible preferred stock warrant liability are re-measured at the end of every period and carried at fair value (Note 3). The recorded value of the Company’s receivables due from related-party and accounts payable approximates its current fair value due to the relatively short-term nature of these items. |
Term Loan | Term Loan The Company accounts for the Loan and Security Agreement, dated as of December 20, 2019, as amended, with Silicon Valley Bank, or SVB, and WestRiver Innovation Lending Fund VIII, LP, or WestRiver, collectively as lenders, and SVB, as administrative agent and collateral agent, as a liability measured at net proceeds less debt discount and is accreted to the face value of the term loan over its expected term using the effective interest method. The Company considers whether there are any embedded features in its debt instruments that require bifurcation and separate accounting as derivative financial instruments pursuant to Accounting Standards Codification, or ASC, Topic 815, Derivatives and Hedging |
Convertible Preferred Stock | Convertible Preferred Stock The Company records convertible preferred stock net of issuance costs on the dates of issuance, which represents the carrying value. In the event of a change of control of the Company, proceeds will be distributed in accordance with the liquidation preferences set forth in its organization documents unless the holders of convertible preferred stock have converted their convertible preferred stock into common stock. Convertible preferred stock are classified outside of stockholders’ deficit on the accompanying condensed consolidated balance sheets as events triggering the liquidation preferences are not solely within the Company’s control. The Company has elected not to adjust the carrying values of the convertible preferred stock to the liquidation preferences of such shares because of the uncertainty of whether or when such an event would occur. Upon the consummation of the Company’s initial public offering in July 2020, all shares of convertible preferred stock outstanding and accrued cumulative dividends were automatically converted into 23,934,533 shares of common stock. See Note 12 to these condensed consolidated financial statements for additional details. |
Revenue Recognition | Revenue Recognition To date, the Company has derived revenue from providing research and development services on a time and materials basis to a related-party. The Company recognizes such revenues over time as services are delivered, and invoices the customer as the work is incurred in arrears. Effective January 1, 2018, the Company adopted ASC Topic 606, Revenue from Contracts with Customers To determine revenue recognition for arrangements that the Company determines are within the scope of Topic 606, the Company performs the following five steps: (i) identify the contract(s) with a customer; (ii) identify the performance obligations in the contract; (iii) determine the transaction price; (iv) allocate the transaction price to the performance obligations in the contract; and (v) recognize revenue when (or as) the Company satisfies a performance obligation. As part of the Company’s consideration as to whether the Company has entered into a contract with a customer, it considers whether it is probable that it will collect the consideration it is entitled to in exchange for the goods and services it transfers to the customer. At contract inception, the Company assesses the goods or services promised within each contract that falls under the scope of Topic 606, determines those that are performance obligations, and assesses whether each promised good or service is distinct. The Company then recognizes as revenue the amount of the transaction price that is allocated to the respective performance obligation when (or as) the performance obligation is satisfied. |
Cost of Services for Related Party Revenue | Cost of Services for Related-Party Revenue The Company incurs costs associated with related-party services including direct labor and associated employee benefits, laboratory supplies, and other expenses. These costs are recorded in cost of services for related-party revenue as a component of total operating expenses in the accompanying condensed consolidated statements of operations and comprehensive loss. |
Research and Development Costs | Research and Development Costs Research and development costs are expensed as incurred and consist primarily of salaries and benefits, stock-based compensation expense, lab supplies and facility costs, as well as fees paid to nonemployees and entities that conduct certain research and development activities on behalf of the Company and expenses incurred in connection with license agreements (Note 8). Nonrefundable advance payments for goods or services to be received in the future for use in research and development activities are capitalized and recorded in prepaid expenses and other current assets, and then expensed as the related goods are delivered or the services are performed. |
Clinical and Manufacturing Accruals | Clinical and Manufacturing Accruals The Company records accruals for estimated costs of research, preclinical studies and clinical trials, and manufacturing development, which are a significant component of research and development expenses. A substantial portion of the Company’s ongoing research and development activities are conducted by third-party service providers, including contract research organizations, or CROs, and contract manufacturing organizations, or CMOs. The Company’s contracts with CROs generally include pass-through fees such as regulatory expenses, investigator fees, travel costs and other miscellaneous costs, including shipping and printing fees. The financial terms of these contracts are subject to negotiations, which vary from contract to contract and may result in payment flows that do not match the periods over which materials or services are provided to the Company under such contracts. The Company accrues the costs incurred under agreements with these third parties based on estimates of actual work completed in accordance with the respective agreements. The Company determines the estimated costs through discussions with internal personnel and external service providers as to the progress or stage of completion of the services and the agreed-upon fees to be paid for such services. The Company makes significant judgments and estimates in determining the accrual balance at the end of each reporting period. As actual costs become known, the Company adjusts its accruals. Although the Company does not expect its estimates to be materially different from amounts actually incurred, the Company’s understanding of the status and timing of services performed relative to the actual status and timing of services performed may vary and could result in the Company reporting amounts that are too high or too low in any particular period. To assist in its estimates the Company relies upon the receipt of timely and accurate reporting from its clinical and non-clinical studies and other third-party vendors. Through June 30, 2020, there have been no material differences from the Company’s accrued estimated expenses to the actual clinical trial expenses. However, variations in the assumptions used to estimate accruals, including, but not limited to, the number of patients enrolled, the rate of patient enrollment, and the actual services performed, and related costs may vary from the Company’s estimates, resulting in adjustments to clinical trial expense in future periods. Changes in these estimates that result in material changes to the Company’s accruals could materially affect its financial position and results of operations. |
Stock-Based Compensation | Stock-based Compensation Expense The Company accounts for stock-based compensation by measuring and recognizing compensation expense for all stock-based payments made to employees, directors and non-employees based on estimated grant-date fair values. The Company uses the straight-line method to allocate compensation expense to reporting periods over each optionee’s requisite service period, which is generally the vesting period, and estimates the fair value of stock-based awards to employees and directors using the Black-Scholes option-pricing model. The Black-Scholes model requires the input of subjective assumptions, including expected volatility, expected dividend yield, expected term, risk-free rate of return and the estimated fair value of the underlying common stock on the date of grant. The Company accounts for the effect of forfeitures as they occur. |
Segment Reporting | Segment Reporting |
Foreign Currency Transactions | Foreign Currency Transactions The functional currency of the Company’s operation and each of its subsidiaries is U.S. dollars. All assets and liabilities denominated in a foreign currency are translated into U.S. dollars at the exchange rate prevailing on the balance sheet date. Expenses are translated at the average exchange rates prevailing during the applicable period. Foreign currency transaction gains and losses are included in the consolidated statement of operations and comprehensive loss and recorded in other expense, net, and were immaterial for the three and six months ended June 30, 2020 and 2019, respectively. |
Income Taxes | Income Taxes The Company accounts for income taxes under the asset and liability method, which requires the recognition of deferred tax assets and liabilities for the expected future tax consequences of events that have been included in the condensed consolidated financial statements. Under this method, deferred tax assets and liabilities are determined on the basis of the differences between the condensed consolidated financial statement carrying amounts and tax bases of assets and liabilities using enacted tax rates in effect for the period in which the temporary differences are expected to reverse. The effect of a change in tax rates on deferred tax assets and liabilities is recognized in the condensed consolidated statements of operations and comprehensive loss in the period that includes the enactment date. The Company recognizes deferred tax assets to the extent that it believes these assets are more likely than not to be realized. In making such a determination, the Company considers all available positive and negative evidence, including future reversals of existing taxable temporary differences, projected future taxable income, tax-planning strategies and results of recent operations. If the Company determines that it would be able to realize its deferred tax assets in the future in excess of their net recorded amount, it would make an adjustment to the deferred tax asset valuation allowance, which would reduce the provision for income taxes. The Company recognizes benefits of uncertain tax positions if it is more likely than not that such positions will be sustained upon examination based solely on their technical merits, as the largest amount of benefit that is more likely than not to be realized upon the ultimate settlement. The Company’s policy is to recognize interest and penalties related to the underpayment of income taxes as a component of income tax expense or benefit. |
Comprehensive Loss | Comprehensive Loss Comprehensive loss is equal to net loss for all periods presented. |
Net Loss Per Share Attributable to Common Stockholders | Net Loss Per Share Attributable to Common Stockholders Basic net loss per share is calculated by dividing the net loss attributable to common stockholders by the weighted-average number of shares of common stock outstanding during the period, without consideration for common stock equivalents. Diluted net loss per share is the same as basic net loss per share, since the effects of potentially dilutive securities are antidilutive given the net loss for each period presented. The Company applies the two-class method to compute basic and diluted net loss per share when it has issued shares that meet the definition of participating securities. The two-class method determines net loss per share for each class of common stock and participating securities according to dividends declared or accumulated and participation rights in undistributed earnings. The two-class method requires net loss available to common stockholders for the period to be allocated between common and participating securities based upon their respective rights to share in the earnings as if all net loss for the period had been distributed. The Company’s convertible preferred stock participate in any dividends declared by the Company and are therefore considered to be participating securities. The participating securities are not required to participate in the losses of the Company, and therefore during periods of loss there is no allocation required under the two-class method. |
Recently Issued Accounting Pronouncements | Recent Accounting Pronouncements In February 2016, the FASB issued ASU No. 2016-02 (Topic 842), Leases In December 2019, the FASB issued ASU No. 2019-12, Income Taxes (Topic 740): Simplifying the Accounting for Income Taxes, which is intended to simplify various aspects related to accounting for income taxes. The pronouncement is effective for fiscal years, and for interim periods within those fiscal years, beginning after December 15, 2021. ASU 2019-12 is effective for the Company beginning January 1, 2022. Early adoption is permitted. The Company is currently in the process of evaluating the effects of the adoption of this guidance on the Company’s financial statements and does not expect it to have a material impact on its condensed consolidated financial statements. |
New Accounting Pronouncements Recently Adopted | New Accounting Pronouncements Recently Adopted In June 2016, the FASB issued ASU No. 2016-13, Financial Instruments-Credit Losses (Topic 326), which requires entities to measure all expected credit losses for financial assets held at the reporting date based on historical experience, current conditions, and reasonable and supportable forecasts. This replaces the existing incurred loss model and is applicable to the measurement of credit losses on financial assets measured at amortized cost. The Company early adopted this guidance on January 1, 2020. The adoption of this guidance did not have a material impact on the Company’s condensed consolidated financial statements. In September 2018, the FASB issued ASU No. 2018-13, Fair Value Measurement (Topic 820): Disclosure Framework—Changes to the Disclosure Requirements for Fair Value Measurement. The FASB issued final guidance that eliminates, adds and modifies certain disclosure requirements for fair value measurements as part of its disclosure framework project. Under the ASU, entities will no longer be required to disclose the amount of transfers between Level 1 and Level 2 of the fair value hierarchy. Public companies will be required to disclose changes in unrealized gains and losses for the period included in other comprehensive income for recurring Level 3 fair value measurements held at the end of the reporting period and the range and weighted average used to develop significant unobservable inputs for Level 3 fair value measurements. ASU 2018-13 is effective for public business entities for annual reporting periods, and interim periods within those annual periods, beginning after December 15, 2019, with early adoption permitted. The Company adopted this guidance on January 1, 2020. The adoption of ASU 2018-13 did not have a material impact on its condensed consolidated financial statements. |
Series B Preferred Stock | |
Convertible Preferred Stock Warrant Liability | Series B Convertible Preferred Stock Warrant Liability The Company has issued freestanding warrants to purchase its Series B convertible preferred stock. Freestanding warrants for the Company’s convertible preferred stock that are classified outside of permanent equity are recorded at fair value, and are subject to re-measurement at the end of every period until the earlier of the exercise of the warrants or the completion of a liquidation event, including the completion of an initial public offering. Upon exercise, the Series B convertible preferred stock warrant liability would be reclassified to additional paid-in capital, with any change in fair value recognized as a component of other expense, net. Following the Company’s initial public offering, the warrants were automatically converted to warrants to purchase shares of common stock. See Note 5 to these condensed consolidated financial statements for additional details. |
Fair Value of Financial Instr_2
Fair Value of Financial Instruments (Tables) | 6 Months Ended |
Jun. 30, 2020 | |
Fair Value Disclosures [Abstract] | |
Financial Liabilities Measured at Fair Value on Recurring Basis | The following table sets forth the Company’s financial liabilities that are measured at fair value on a recurring basis by level within the fair value hierarchy (in thousands): As of June 30, 2020 Level 1 Level 2 Level 3 Fair Value Financial assets Cash equivalents Money market funds $ 90,110 — — $ 90,110 Financial liabilities Non-current liabilities Compound derivative liability $ — — 64 $ 64 Warrant liability $ — — 756 $ 756 As of December 31, 2019 Level 1 Level 2 Level 3 Fair Value Financial liabilities Non-current liabilities Compound derivative liability $ — — 51 $ 51 Warrant liability $ — — 361 $ 361 |
Reconciliation of Financial Liabilities Measured at Fair Value Using Level 3 Unobservable Inputs | The following table is a reconciliation of all financial liabilities measured at fair value using Level 3 unobservable inputs (in thousands): Compound Warrant Derivative Liability Liability Fair value at December 31, 2019 $ 361 $ 51 Change in fair value 395 13 Fair value at June 30, 2020 $ 756 $ 64 |
Balance Sheet Components (Table
Balance Sheet Components (Tables) | 6 Months Ended |
Jun. 30, 2020 | |
Balance Sheet Related Disclosures [Abstract] | |
Schedule of Components of Property and Equipment | The following table presents the components of property and equipment, net as of June 30, 2020 and December 31, 2019 (in thousands): June 30, December 31, 2020 2019 Computer hardware and software $ 61 $ 146 Machinery and equipment 41 1,698 Furniture and fixtures 9 36 Leasehold improvements 18 429 129 2,309 Less: accumulated depreciation and amortization (92 ) (1,449 ) Total property and equipment, net $ 37 $ 860 |
Components of Accrued Expenses and Other Current Liabilities | The following table presents the components of accrued expenses and other current liabilities as of June 30, 2020 and December 31, 2019 (in thousands): June 30, December 31, 2020 2019 Accrued professional fees $ 2,219 $ 122 Accrued compensation 671 924 Accrued clinical and nonclinical study costs 800 — Accrued contract manufacturing 149 53 Other 301 137 Total accrued expenses and other current liabilities $ 4,140 $ 1,236 |
Term Loan (Tables)
Term Loan (Tables) | 6 Months Ended |
Jun. 30, 2020 | |
Debt Disclosure [Abstract] | |
Schedule of Future Payments of Principal and Interest | The following table presents future payments of principal and interest as of June 30, 2020 is as follows (in thousands): June 30, 2020 2020 (remaining six months) $ 214 2021 3,743 2022 3,007 6,964 Less: amount representing interest $ (604 ) Less: amount representing final payment (360 ) Term loan, gross 6,000 Less: unamortized issuance costs and debt discounts (358 ) Less: current portion (1,714 ) Non-current portion of term loan $ 3,928 |
Capital Structure (Tables)
Capital Structure (Tables) | 6 Months Ended |
Jun. 30, 2020 | |
Equity [Abstract] | |
Common Stock Reserved for Future Issuance on Converted Basis | Common stock reserved for future issuance, on an as if converted basis, as of June 30, 2020 and December 31, 2019, consists of the following and have been adjusted for the 1-for-6.5806 reverse split: June 30, December 31, 2020 2019 Convertible preferred stock issued and outstanding 21,369,774 10,313,808 Stock options issued and outstanding 3,874,815 1,183,745 Stock options authorized for future issuance 111,869 566,900 Warrants issued and outstanding 61,292 61,292 Warrants authorized for future issuance — 30,646 Total 25,417,750 12,156,391 |
Summary of Convertible Preferred Stock | As of June 30, 2020 and December 31, 2019, the Company’s convertible preferred stock consisted of the following and have been adjusted for the 1-for-6.5806 reverse split (in thousands, except share amounts): June 30, 2020 Shares Aggregate Authorized Issued And Net Liquidation Shares Outstanding Proceeds (1) Preference Shares designated as: Series A convertible preferred stock 9,297,100 9,297,081 $ 60,933 $ 75,412 Series B convertible preferred stock 1,108,675 1,016,727 9,430 10,304 Series C convertible preferred stock 11,055,981 11,055,966 104,680 107,504 Total 21,461,756 21,369,774 $ 175,043 $ 193,220 December 31, 2019 Shares Aggregate Authorized Issued And Net Liquidation Shares Outstanding Proceeds (1) Preference Shares designated as: Series A convertible preferred stock 9,421,633 9,297,081 $ 60,933 $ 73,571 Series B convertible preferred stock 2,145,370 1,016,727 9,430 10,014 Total 11,567,003 10,313,808 $ 70,363 $ 83,585 (1) Net proceeds are gross proceeds from the offerings net of issuance costs. |
Stock-Based Compensation (Table
Stock-Based Compensation (Tables) | 6 Months Ended |
Jun. 30, 2020 | |
Disclosure Of Compensation Related Costs Sharebased Payments [Abstract] | |
Summary of Total Stock Based Compensation Expense | Total stock-based compensation expense recognized in the condensed consolidated statements of operations and comprehensive loss was as follows (in thousands): Three Months Ended June 30, Six Months Ended June 30, 2020 2019 2020 2019 Research and development $ 2,284 $ 19 $ 2,367 $ 54 General and administrative 569 7 637 14 Cost of services for related-party revenue — 34 — 68 $ 2,853 $ 60 $ 3,004 $ 136 |
Net Loss Per Share Attributab_2
Net Loss Per Share Attributable to Common Stockholders (Tables) | 6 Months Ended |
Jun. 30, 2020 | |
Earnings Per Share [Abstract] | |
Computation of Basic and Diluted Net Loss per Share | The following table sets forth the computation of the basic and diluted net loss per share attributable to common stockholders (in thousands, except share and per share data): Three Months Ended June 30, Six Months Ended June 30, 2020 2019 2020 2019 Numerator: Net loss $ (11,331 ) $ (4,197 ) $ (16,785 ) $ (8,435 ) Less: cumulative preferred dividends allocated to preferred stockholders (2,641 ) (981 ) (4,624 ) (1,886 ) Net loss attributable to common stockholders $ (13,972 ) $ (5,178 ) $ (21,409 ) $ (10,321 ) Denominator: Weighted-average shares of common stock outstanding 3,164,707 3,087,355 3,157,387 3,047,924 Net loss per share attributable to common stockholders, basic and diluted $ (4.41 ) $ (1.68 ) $ (6.78 ) $ (3.39 ) |
Summary of Outstanding Potentially Dilutive Securities Were Excluded from Computation of Diluted Net Loss Per Share | The following outstanding potentially dilutive securities were excluded from the computation of diluted net loss per share for the periods presented because including them would have been anti-dilutive: June 30, 2020 2019 Convertible preferred stock 21,369,774 10,313,808 Warrants to purchase convertible preferred stock 61,292 — Common stock subject to repurchase 3,908 72,714 Options issued and outstanding 3,874,815 924,043 Total 25,309,789 11,310,565 |
Commitments and Contingencies (
Commitments and Contingencies (Tables) | 6 Months Ended |
Jun. 30, 2020 | |
Commitments And Contingencies Disclosure [Abstract] | |
Summary of Company's Commitments and Contractual Obligations | The following table summarizes the Company’s commitments and contractual obligations as of June 30, 2020 (in thousands): Year Ended December 31: Operating lease obligations (1) Manufacturing and service contracts (2) Term loan (3) 2020 (remaining six months) $ 273 $ 4,511 $ 214 2021 560 1,563 3,743 2022 577 298 3,007 2023 247 — — Total $ 1,657 $ 6,372 $ 6,964 (1) Payments due for the office and laboratory space in Burlingame, California under a single operating lease agreement that expires in 2023. In July 2020, the Company assigned this lease to Tallac Therapeutics, and the Company received a sublease for such premises from Tallac Therapeutics. See Note 12 to these condensed consolidated financial statements for additional details. (2) In November 2015, the Company entered into a Master Service Agreement, or the MSA, with KBI Biopharma, Inc. relating to formulation development, process development and cGMP manufacturing of ALX148 for use in clinical trials on a project basis. The MSA had an initial term of three years with successive one-year renewal periods, is cancellable upon notice and is non-exclusive. Statements of work under the MSA commit the Company to certain purchase obligations of approximately $6.1 million. In addition, the Company has commitments with a second drug product manufacturer that commits the Company to certain purchase obligations of approximately $0.3 million. These amounts are based on non-cancellable commitments and forecasts that include estimates of future market demand, quantity discounts and manufacturing efficiencies that may impact timing of purchases. (3) On December 20, 2019, the Company borrowed a loan pursuant to the Loan Agreement. See Note 5 to these condensed consolidated financial statements for additional details. |
Subsequent Events (Tables)
Subsequent Events (Tables) | 6 Months Ended |
Jun. 30, 2020 | |
Pro Forma | |
Impact of Initial Public Offering on Condensed Consolidated Balance Sheet Items | The table below shows, on a pro forma basis, the impact of the Company’s initial public offering on certain condensed consolidated balance sheet items as if all of the transactions occurred on June 30, 2020 (in thousands): Pro Forma June 30, 2020 June 30, 2020 Cash and cash equivalents $ 98,103 $ 270,827 Deferred offering costs 2,411 — Convertible preferred stock 175,043 — Common stock 3 37 Additional paid-in capital 5,166 351,244 Total stockholders' equity (deficit) $ (84,398 ) $ 261,714 |
Organization - Additional Infor
Organization - Additional Information (Details) - USD ($) $ in Thousands | 1 Months Ended | 6 Months Ended | |
Jul. 31, 2020 | Jun. 30, 2020 | Dec. 31, 2019 | |
Organization [Line Items] | |||
Cash and cash equivalents | $ 98,103 | $ 9,017 | |
Initial Public Offering | Common Stock | |||
Organization [Line Items] | |||
Net proceeds from initial public offering | $ 172,700 | ||
Initial Public Offering | Subsequent Event | Common Stock | |||
Organization [Line Items] | |||
Shares issued | 9,775,000 | ||
Net proceeds from initial public offering | $ 172,700 | ||
Underwriting discounts and commissions paid | $ 13,000 | ||
Convertible shares converted into common stock | 23,934,533 |
Significant Accounting Polici_3
Significant Accounting Policies - Additional Information (Details) | Jul. 08, 2020 | Jun. 30, 2020USD ($) | Jun. 30, 2019USD ($) | Jun. 30, 2020USD ($)Segment | Jun. 30, 2019USD ($) | Jul. 31, 2020shares |
Significant Accounting Policies [Line Items] | ||||||
Reverse stock split, description | On July 8, 2020, the Company’s board of directors approved an amendment to the Company’s certificate of incorporation to effect a 1-for-6.5806 reverse split of its common stock and convertible preferred stock. | |||||
Deferred offering costs | $ 2,411,000 | $ 2,411,000 | ||||
Impairment charges | $ 0 | $ 0 | $ 0 | $ 0 | ||
Number of operating segment | Segment | 1 | |||||
ASU 2016-13 | ||||||
Significant Accounting Policies [Line Items] | ||||||
Change in Accounting Principle, Accounting Standards Update, Adopted [true false] | true | true | ||||
Change in Accounting Principle, Accounting Standards Update, Adoption Date | Jan. 1, 2020 | Jan. 1, 2020 | ||||
Change in Accounting Principle, Accounting Standards Update, Immaterial Effect [true false] | true | true | ||||
ASU 2018-13 | ||||||
Significant Accounting Policies [Line Items] | ||||||
Change in Accounting Principle, Accounting Standards Update, Adopted [true false] | true | true | ||||
Change in Accounting Principle, Accounting Standards Update, Adoption Date | Jan. 1, 2020 | Jan. 1, 2020 | ||||
Change in Accounting Principle, Accounting Standards Update, Immaterial Effect [true false] | true | true | ||||
Common Stock | ||||||
Significant Accounting Policies [Line Items] | ||||||
Reverse stock split, description | 1-for-6.5806 reverse split | |||||
Subsequent Event | ||||||
Significant Accounting Policies [Line Items] | ||||||
Reverse stock split, conversion ratio | 0.151961827 | |||||
Subsequent Event | Initial Public Offering | Common Stock | ||||||
Significant Accounting Policies [Line Items] | ||||||
Convertible shares converted into common stock | shares | 23,934,533 |
Fair Value of Financial Instr_3
Fair Value of Financial Instruments - Financial Liabilities Measured at Fair Value on Recurring Basis (Details) - Fair Value on Recurring Basis - USD ($) $ in Thousands | Jun. 30, 2020 | Dec. 31, 2019 |
Financial liabilities | ||
Compound derivative liability | $ 64 | $ 51 |
Warrant liability | 756 | 361 |
Money Market Funds | ||
Financial assets | ||
Cash equivalents | 90,110 | |
Level 1 | Money Market Funds | ||
Financial assets | ||
Cash equivalents | 90,110 | |
Level 3 | ||
Financial liabilities | ||
Compound derivative liability | 64 | 51 |
Warrant liability | $ 756 | $ 361 |
Fair Value of Financial Instr_4
Fair Value of Financial Instruments - Reconciliation of Financial Liabilities Measured at Fair Value Using Level 3 Unobservable Inputs (Details) - Level 3 $ in Thousands | 6 Months Ended |
Jun. 30, 2020USD ($) | |
Warrant Liability | |
Fair Value Liabilities Measured On Recurring Basis Unobservable Input Reconciliation [Line Items] | |
Fair value at December 31, 2019 | $ 361 |
Change in fair value | 395 |
Fair value at June 30, 2020 | 756 |
Compound Derivative Liability | |
Fair Value Liabilities Measured On Recurring Basis Unobservable Input Reconciliation [Line Items] | |
Fair value at December 31, 2019 | 51 |
Change in fair value | 13 |
Fair value at June 30, 2020 | $ 64 |
Fair Value of Financial Instr_5
Fair Value of Financial Instruments - Additional Information (Details) | 6 Months Ended | 12 Months Ended |
Jun. 30, 2020USD ($) | Dec. 31, 2019USD ($) | |
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items] | ||
Fair value assets transferred from level 1 to level 2 | $ 0 | $ 0 |
Fair value assets transferred from level 2 to level 1 | 0 | 0 |
Fair value liabilities transferred from level 1 to level 2 | 0 | 0 |
Fair value liabilities transferred from level 2 to level 1 | 0 | 0 |
Fair value assets transferred into level 3 | 0 | 0 |
Fair value assets transferred out of level 3 | 0 | 0 |
Fair value liabilities transferred into level 3 | 0 | 0 |
Fair value liabilities transferred out of level 3 | $ 0 | $ 0 |
Discount Rate | Term Loan | ||
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items] | ||
Valuation assumptions rate | 16.5 | |
Probability of Occurrence | Term Loan | ||
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items] | ||
Valuation assumptions rate | 10 | |
Level 3 | Market Yield Analysis and Income Approach | Term Loan | ||
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items] | ||
Estimated fair value | $ 5,800,000 |
Balance Sheet Components - Sche
Balance Sheet Components - Schedule of Components of Property and Equipment (Details) - USD ($) $ in Thousands | Jun. 30, 2020 | Dec. 31, 2019 |
Property Plant And Equipment [Line Items] | ||
Property and equipment, gross | $ 129 | $ 2,309 |
Less: accumulated depreciation and amortization | (92) | (1,449) |
Total property and equipment, net | 37 | 860 |
Computer Hardware and Software | ||
Property Plant And Equipment [Line Items] | ||
Property and equipment, gross | 61 | 146 |
Machinery and Equipment | ||
Property Plant And Equipment [Line Items] | ||
Property and equipment, gross | 41 | 1,698 |
Furniture and Fixtures | ||
Property Plant And Equipment [Line Items] | ||
Property and equipment, gross | 9 | 36 |
Leasehold Improvements | ||
Property Plant And Equipment [Line Items] | ||
Property and equipment, gross | $ 18 | $ 429 |
Balance Sheet Components - Addi
Balance Sheet Components - Additional Information (Details) - USD ($) $ in Thousands | 1 Months Ended | 3 Months Ended | 6 Months Ended | |||
Jul. 31, 2020 | Jun. 30, 2020 | Jun. 30, 2019 | Jun. 30, 2020 | Jun. 30, 2019 | Dec. 31, 2019 | |
Schedule Of Balance Sheet Components [Line Items] | ||||||
Depreciation and amortization expense | $ 100 | $ 100 | $ 200 | $ 200 | ||
Property and equipment | 37 | 37 | $ 860 | |||
Lab Equipment and Other Assets | ||||||
Schedule Of Balance Sheet Components [Line Items] | ||||||
Property and equipment | $ 600 | $ 600 | ||||
Lab Equipment and Other Assets | Subsequent Event | ||||||
Schedule Of Balance Sheet Components [Line Items] | ||||||
Proceeds from transfer of assets for cash | $ 600 |
Balance Sheet Components - Comp
Balance Sheet Components - Components of Accrued Expenses and Other Current Liabilities (Details) - USD ($) $ in Thousands | Jun. 30, 2020 | Dec. 31, 2019 |
Balance Sheet Related Disclosures [Abstract] | ||
Accrued professional fees | $ 2,219 | $ 122 |
Accrued compensation | 671 | 924 |
Accrued clinical and nonclinical study costs | 800 | |
Accrued contract manufacturing | 149 | 53 |
Other | 301 | 137 |
Total accrued expenses and other current liabilities | $ 4,140 | $ 1,236 |
Term Loan - Additional Informat
Term Loan - Additional Information (Details) | Dec. 20, 2019USD ($)$ / sharesshares | Jun. 30, 2020USD ($) | Mar. 31, 2020USD ($) | Jun. 30, 2020USD ($) | Dec. 31, 2019USD ($) |
Debt Instrument [Line Items] | |||||
Unamortized issuance costs and debt discounts | $ 358,000 | $ 358,000 | |||
Interest expense for term loan | 200,000 | 400,000 | |||
Compound Derivative Liability | |||||
Debt Instrument [Line Items] | |||||
Fair value of compound derivative liability | $ 51,000 | ||||
Other Non-current Liabilities | Compound Derivative Liability | |||||
Debt Instrument [Line Items] | |||||
Fair value of compound derivative liability | 64,000 | $ 64,000 | |||
Loan Agreement | |||||
Debt Instrument [Line Items] | |||||
Debt instrument, description of variable rate basis | The loans under the Loan Agreement bear interest at a floating per annum interest rate equal to the greater of 7.0% or 2.0% plus the prime rate as reported in The Wall Street Journal. The Wall Street Journal prime rate was 3.25% as of June 30, 2020. Therefore, the rate applicable to the Company as of June 30, 2020 was 7.0%. | ||||
Term loan, annual floating interest rate | 7.00% | ||||
Term loan, interest rate | 7.00% | ||||
Term loan interest-only payments, term | Interest-only payments for the first 12 months after the closing of the Loan Agreement | ||||
Frequency of periodic payment | monthly | ||||
Term loan principal and interest payment commencement date | Jan. 1, 2021 | ||||
Term loan maturity date | Sep. 1, 2022 | ||||
Percentage of principal amount as final payment | 6.00% | ||||
Loan Agreement | Common Stock | |||||
Debt Instrument [Line Items] | |||||
Warrants to purchase common stock | shares | 61,292 | ||||
Common stock exercise price per share | $ / shares | $ 9.4972 | ||||
Loan Agreement | Series B Convertible Preferred Stock | |||||
Debt Instrument [Line Items] | |||||
Warrants issued to purchase | shares | 61,292 | ||||
Warrant exercise price per share | $ / shares | $ 9.4972 | ||||
Estimated fair value of warrants | $ 400,000 | ||||
Loan Agreement | Other Non-current Liabilities | Series B Convertible Preferred Stock | |||||
Debt Instrument [Line Items] | |||||
Fair value of warrant liability | $ 800,000 | $ 800,000 | |||
Loan Agreement | Volatility | Series B Convertible Preferred Stock | |||||
Debt Instrument [Line Items] | |||||
Warrants and rights outstanding, measurement input | 99.9 | 99.9 | |||
Loan Agreement | Risk-free Rate | Series B Convertible Preferred Stock | |||||
Debt Instrument [Line Items] | |||||
Warrants and rights outstanding, measurement input | 0.6 | 0.6 | |||
Loan Agreement | Prime Rate | |||||
Debt Instrument [Line Items] | |||||
Term loan, interest rate above prime rate | 2.00% | ||||
Percentage of prime rate | 3.25% | ||||
Loan Agreement | Maximum | |||||
Debt Instrument [Line Items] | |||||
Term loan, principal amount | $ 10,000,000 | ||||
Prepayment fee percentage | 3.00% | ||||
Loan Agreement | Maximum | Time to Liquidity | Series B Convertible Preferred Stock | |||||
Debt Instrument [Line Items] | |||||
Warrants and rights outstanding, measurement input term | 9 years 6 months | 9 years 6 months | |||
Loan Agreement | Minimum | |||||
Debt Instrument [Line Items] | |||||
Proceeds from equity financing | $ 30,000,000 | ||||
Prepayment fee percentage | 1.00% | ||||
Loan Agreement | Minimum | Time to Liquidity | Series B Convertible Preferred Stock | |||||
Debt Instrument [Line Items] | |||||
Warrants and rights outstanding, measurement input term | 2 years | 2 years | |||
First Tranche | Loan Agreement | |||||
Debt Instrument [Line Items] | |||||
Term loan, principal amount | $ 6,000,000 | ||||
Second Tranche | Loan Agreement | |||||
Debt Instrument [Line Items] | |||||
Term loan, principal amount | $ 4,000,000 |
Term Loan - Schedule of Future
Term Loan - Schedule of Future Payments of Principal and Interest (Details) - USD ($) $ in Thousands | Jun. 30, 2020 | Dec. 31, 2019 |
Debt Disclosure [Abstract] | ||
2020 (remaining six months) | $ 214 | |
2021 | 3,743 | |
2022 | 3,007 | |
Future payments of principal and interest | 6,964 | |
Less: amount representing interest | (604) | |
Less: amount representing final payment | (360) | |
Term loan, gross | 6,000 | |
Less: unamortized issuance costs and debt discounts | (358) | |
Less: current portion | (1,714) | |
Non-current portion of term loan | $ 3,928 | $ 5,421 |
Capital Structure - Additional
Capital Structure - Additional Information (Details) | 6 Months Ended |
Jun. 30, 2020 | |
Class Of Stock [Line Items] | |
Reverse stock split, description | On July 8, 2020, the Company’s board of directors approved an amendment to the Company’s certificate of incorporation to effect a 1-for-6.5806 reverse split of its common stock and convertible preferred stock. |
Convertible Preferred Stock | |
Class Of Stock [Line Items] | |
Reverse stock split, description | 1-for-6.5806 reverse split |
Common Stock | |
Class Of Stock [Line Items] | |
Reverse stock split, description | 1-for-6.5806 reverse split |
Capital Structure - Common Stoc
Capital Structure - Common Stock Reserved for Future Issuance on Converted Basis (Details) - shares | Jun. 30, 2020 | Dec. 31, 2019 |
Class Of Stock [Line Items] | ||
Common stock reserved for future issuance | 25,417,750 | 12,156,391 |
Convertible Preferred Stock Issued and Outstanding | ||
Class Of Stock [Line Items] | ||
Common stock reserved for future issuance | 21,369,774 | 10,313,808 |
Stock Options Issued and Outstanding | ||
Class Of Stock [Line Items] | ||
Common stock reserved for future issuance | 3,874,815 | 1,183,745 |
Stock Options Authorized for Future Issuance | ||
Class Of Stock [Line Items] | ||
Common stock reserved for future issuance | 111,869 | 566,900 |
Warrants Issued and Outstanding | ||
Class Of Stock [Line Items] | ||
Common stock reserved for future issuance | 61,292 | 61,292 |
Warrants Authorized for Future Issuance | ||
Class Of Stock [Line Items] | ||
Common stock reserved for future issuance | 30,646 |
Capital Structure - Summary of
Capital Structure - Summary of Convertible Preferred Stock (Details) - USD ($) $ in Thousands | Jun. 30, 2020 | Dec. 31, 2019 |
Class Of Stock [Line Items] | ||
Authorized Shares | 21,461,756 | 11,567,003 |
Shares Issued And Outstanding | 21,369,774 | 10,313,808 |
Net Proceeds | $ 175,043 | $ 70,363 |
Aggregate Liquidation Preference | $ 193,220 | $ 83,585 |
Series A Convertible Preferred Stock | ||
Class Of Stock [Line Items] | ||
Authorized Shares | 9,297,100 | 9,421,633 |
Shares Issued And Outstanding | 9,297,081 | 9,297,081 |
Net Proceeds | $ 60,933 | $ 60,933 |
Aggregate Liquidation Preference | $ 75,412 | $ 73,571 |
Series B Convertible Preferred Stock | ||
Class Of Stock [Line Items] | ||
Authorized Shares | 1,108,675 | 2,145,370 |
Shares Issued And Outstanding | 1,016,727 | 1,016,727 |
Net Proceeds | $ 9,430 | $ 9,430 |
Aggregate Liquidation Preference | $ 10,304 | $ 10,014 |
Series C Convertible Preferred Stock | ||
Class Of Stock [Line Items] | ||
Authorized Shares | 11,055,981 | 0 |
Shares Issued And Outstanding | 11,055,966 | |
Net Proceeds | $ 104,680 | |
Aggregate Liquidation Preference | $ 107,504 | $ 0 |
Stock-Based Compensation - Addi
Stock-Based Compensation - Additional Information (Details) - USD ($) $ in Thousands | 3 Months Ended | 6 Months Ended | ||||
Jun. 30, 2020 | Jun. 30, 2019 | Jun. 30, 2020 | Jun. 30, 2019 | Jul. 31, 2020 | Dec. 31, 2019 | |
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] | ||||||
Shares reserved for future issuance | 25,417,750 | 25,417,750 | 12,156,391 | |||
Stock-based compensation expenses | $ 2,853 | $ 60 | $ 3,004 | $ 136 | ||
Stock Option Modification | ||||||
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] | ||||||
Stock-based compensation expenses | $ 2,300 | |||||
2020 Plan | Subsequent Event | ||||||
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] | ||||||
Shares reserved for future issuance | 7,874,862 |
Stock-Based Compensation - Summ
Stock-Based Compensation - Summary of Total Stock Based Compensation Expense (Details) - USD ($) $ in Thousands | 3 Months Ended | 6 Months Ended | ||
Jun. 30, 2020 | Jun. 30, 2019 | Jun. 30, 2020 | Jun. 30, 2019 | |
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] | ||||
Total stock-based compensation expense | $ 2,853 | $ 60 | $ 3,004 | $ 136 |
Research and Development | ||||
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] | ||||
Total stock-based compensation expense | 2,284 | 19 | 2,367 | 54 |
General and Administrative | ||||
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] | ||||
Total stock-based compensation expense | $ 569 | 7 | $ 637 | 14 |
Cost of Services for Related-party Revenue | ||||
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] | ||||
Total stock-based compensation expense | $ 34 | $ 68 |
License Agreement - Additional
License Agreement - Additional Information (Details) $ in Millions | 6 Months Ended |
Jun. 30, 2020USD ($) | |
Exclusive Equity Agreement | Stanford Junior University | |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] | |
Nonrefundable license royalty and patent expenses | $ 0.1 |
Clinical and regulatory milestones payments | $ 5 |
Agreement expiry description | licensed patents expires and ten years after the first commercial sale of the licensed product in such country |
Termination of agreement written notice period | 60 days |
Notice period to remedy the breach of agreement | 60 days |
Commercial License Agreement | Selexis SA | |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] | |
Clinical and regulatory milestones payments | $ 1.2 |
Agreement expiry description | shall terminate and become fully paid-up upon the passing of ten years after the first commercial sale of the product in such country, or the Company’s exercise of the royalty buyout option exercisable at any time prior to the first commercial sale of a licensed product |
Termination of agreement written notice period | 60 days |
Notice period to remedy the breach of agreement | 60 days |
Commercial Antibody Agreement | Crystal Bioscience Inc | |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] | |
Clinical and regulatory milestones payments | $ 11.1 |
Agreement expiry description | licensed patents expires and ten years after the first commercial sale of the product in such country |
Termination of agreement written notice period | 60 days |
Notice period to remedy the breach of agreement | 60 days |
Related-Party Transactions - Ad
Related-Party Transactions - Additional Information (Details) $ in Thousands | 1 Months Ended | 3 Months Ended | 6 Months Ended | |||
Jun. 30, 2018 | Jun. 30, 2020USD ($) | Jun. 30, 2019USD ($) | Jun. 30, 2020USD ($)Investor | Jun. 30, 2019USD ($) | Dec. 31, 2019USD ($) | |
Related Party Transaction [Line Items] | ||||||
Related-party revenue | $ 527 | $ 1,295 | $ 1,182 | $ 2,327 | ||
Tollnine | ||||||
Related Party Transaction [Line Items] | ||||||
Outstanding related-party receivables | 500 | $ 500 | $ 500 | |||
Tollnine | Research and Development Services Agreement | ||||||
Related Party Transaction [Line Items] | ||||||
Number of company's investors who are investors in related party as well | Investor | 2 | |||||
Related-party revenue | $ 500 | $ 1,300 | $ 1,200 | $ 2,300 | ||
Initial term of agreement with related party | 3 years | |||||
Agreement automatically renewal additional term unless terminated | 1 year | |||||
Markup cost in percentage | 10.00% |
Net Loss Per Share Attributab_3
Net Loss Per Share Attributable to Common Stockholders - Computation of Basic and Diluted Net Loss per Share (Details) - USD ($) $ / shares in Units, $ in Thousands | 3 Months Ended | 6 Months Ended | ||||
Jun. 30, 2020 | Mar. 31, 2020 | Jun. 30, 2019 | Mar. 31, 2019 | Jun. 30, 2020 | Jun. 30, 2019 | |
Numerator: | ||||||
Net loss | $ (11,331) | $ (5,454) | $ (4,197) | $ (4,238) | $ (16,785) | $ (8,435) |
Less: cumulative preferred dividends allocated to preferred stockholders | (2,641) | (981) | (4,624) | (1,886) | ||
Net loss attributable to common stockholders | $ (13,972) | $ (5,178) | $ (21,409) | $ (10,321) | ||
Denominator: | ||||||
Weighted-average shares of common stock outstanding | 3,164,707 | 3,087,355 | 3,157,387 | 3,047,924 | ||
Net loss per share attributable to common stockholders, basic and diluted | $ (4.41) | $ (1.68) | $ (6.78) | $ (3.39) |
Net Loss Per Share Attributab_4
Net Loss Per Share Attributable to Common Stockholders - Summary of Outstanding Potentially Dilutive Securities Were Excluded from Computation of Diluted Net Loss Per Share (Details) - shares | 6 Months Ended | |
Jun. 30, 2020 | Jun. 30, 2019 | |
Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items] | ||
Antidilutive securities excluded from computation of earnings per share | 25,309,789 | 11,310,565 |
Convertible Preferred Stock | ||
Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items] | ||
Antidilutive securities excluded from computation of earnings per share | 21,369,774 | 10,313,808 |
Warrants to Purchase Convertible Preferred Stock | ||
Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items] | ||
Antidilutive securities excluded from computation of earnings per share | 61,292 | |
Common Stock Subject to Repurchase | ||
Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items] | ||
Antidilutive securities excluded from computation of earnings per share | 3,908 | 72,714 |
Options Issued and Outstanding | ||
Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items] | ||
Antidilutive securities excluded from computation of earnings per share | 3,874,815 | 924,043 |
Commitments and Contingencies -
Commitments and Contingencies - Summary of Company's Commitments and Contractual Obligations (Details) $ in Thousands | Jun. 30, 2020USD ($) |
Operating lease obligations | |
2020 (remaining six months) | $ 273 |
2021 | 560 |
2022 | 577 |
2023 | 247 |
Total | 1,657 |
Manufacturing and service contracts | |
2020 (remaining six months) | 4,511 |
2021 | 1,563 |
2022 | 298 |
Total | 6,372 |
Term loan | |
2020 (remaining six months) | 214 |
2021 | 3,743 |
2022 | 3,007 |
Total | $ 6,964 |
Commitments and Contingencies_2
Commitments and Contingencies - Summary of Company's Commitments and Contractual Obligations (Parenthetical) (Details) - USD ($) $ in Thousands | 1 Months Ended | 6 Months Ended |
Nov. 30, 2015 | Jun. 30, 2020 | |
Commitments And Contingencies [Line Items] | ||
Purchase obligations | $ 6,372 | |
Master Service Agreement | ||
Commitments And Contingencies [Line Items] | ||
Initial term of agreement | 3 years | |
Renewal periods of agreement | 1 year | |
Purchase obligations | $ 6,100 | |
Office and Laboratory Space | Burlingame, California | ||
Commitments And Contingencies [Line Items] | ||
Operating lease expiration year | 2023 | |
Second Drug Product Manufacturer | Master Service Agreement | ||
Commitments And Contingencies [Line Items] | ||
Purchase obligations | $ 300 |
Commitments and Contingencies_3
Commitments and Contingencies - Additional Information (Details) - USD ($) $ in Millions | 3 Months Ended | 6 Months Ended | 12 Months Ended | ||
Jun. 30, 2020 | Jun. 30, 2019 | Jun. 30, 2020 | Jun. 30, 2019 | Dec. 31, 2017 | |
Commitments And Contingencies [Line Items] | |||||
Rent expense | $ 0.2 | $ 0.2 | $ 0.4 | $ 0.4 | |
Series A, Series B and Series C Convertible Preferred Stock | |||||
Commitments And Contingencies [Line Items] | |||||
Accrued cumulative dividends | $ 17.4 | $ 17.4 | |||
Office Space | |||||
Commitments And Contingencies [Line Items] | |||||
Lessee, operating lease, term of contract | 5 years 4 months | ||||
Lessee, operating lease commencing end date | May 31, 2023 |
Subsequent Events - Additional
Subsequent Events - Additional Information (Details) - USD ($) $ / shares in Units, $ in Millions | Jul. 01, 2020 | Jul. 31, 2020 | Jun. 30, 2020 | Mar. 31, 2020 | Dec. 31, 2019 | Jun. 30, 2019 | Mar. 31, 2019 | Dec. 31, 2018 |
Subsequent Event [Line Items] | ||||||||
Common stock, shares outstanding | 3,166,946 | 3,166,946 | ||||||
Common stock, shares authorized | 1,519,618,271 | 1,519,618,271 | ||||||
Convertible preferred stock, shares authorized | 21,461,756 | 11,567,003 | ||||||
Convertible Preferred Stock | ||||||||
Subsequent Event [Line Items] | ||||||||
Convertible preferred stock, shares outstanding | 21,369,774 | 21,369,774 | 10,313,808 | 10,313,808 | 9,297,081 | 9,297,081 | ||
Initial Public Offering | Common Stock | ||||||||
Subsequent Event [Line Items] | ||||||||
Net proceeds from initial public offering | $ 172.7 | |||||||
Subsequent Event | ||||||||
Subsequent Event [Line Items] | ||||||||
Common stock, shares authorized | 1,000,000,000 | |||||||
Subsequent Event | Convertible Preferred Stock | ||||||||
Subsequent Event [Line Items] | ||||||||
Convertible preferred stock, shares outstanding | 21,369,774 | |||||||
Temporary equity accrued cumulative dividends shares | 2,564,759 | |||||||
Subsequent Event | Undesignated Preferred Stock | ||||||||
Subsequent Event [Line Items] | ||||||||
Convertible preferred stock, shares authorized | 100,000,000 | |||||||
Subsequent Event | Common Stock | ||||||||
Subsequent Event [Line Items] | ||||||||
Conversion of stock shares issued | 23,934,533 | |||||||
Subsequent Event | Initial Public Offering | ||||||||
Subsequent Event [Line Items] | ||||||||
Common stock, shares outstanding | 36,876,479 | |||||||
Subsequent Event | Initial Public Offering | Common Stock | ||||||||
Subsequent Event [Line Items] | ||||||||
Shares of common stock issued | 9,775,000 | |||||||
Offering price per share | $ 19 | |||||||
Net proceeds from initial public offering | $ 172.7 | |||||||
Underwriting discounts and commissions | $ 13 | |||||||
Subsequent Event | Over-Allotment Option | Common Stock | ||||||||
Subsequent Event [Line Items] | ||||||||
Shares of common stock issued | 1,275,000 | |||||||
Subsequent Event | Tallac Services Agreement | ||||||||
Subsequent Event [Line Items] | ||||||||
Percentage of service fee based costs incurred | 10.00% | |||||||
Services agreements, initial term | 4 years | |||||||
Services agreement automatically renewed | 1 year | |||||||
Subsequent Event | Dr. Wan Consulting Agreement | ||||||||
Subsequent Event [Line Items] | ||||||||
Percentage of time performing activities | 20.00% | |||||||
Consulting agreements, initial term | 4 years | |||||||
Consulting agreement automatically renewed | 4 years | |||||||
Subsequent Event | Asset Transfer Agreement | ||||||||
Subsequent Event [Line Items] | ||||||||
Sale of lab equipment and other assets | $ 0.6 | |||||||
Cash in exchange for transfer of assets | $ 0.6 |
Subsequent Events - Impact of I
Subsequent Events - Impact of Initial Public Offering on Condensed Consolidated Balance Sheet Items (Details) - USD ($) $ in Thousands | Jun. 30, 2020 | Mar. 31, 2020 | Dec. 31, 2019 | Jun. 30, 2019 | Mar. 31, 2019 | Dec. 31, 2018 |
Subsequent Event [Line Items] | ||||||
Cash and cash equivalents | $ 98,103 | $ 9,017 | ||||
Deferred offering costs | 2,411 | |||||
Convertible preferred stock | 175,043 | 70,363 | ||||
Common stock | 3 | 3 | ||||
Additional paid-in capital | 5,166 | 2,140 | ||||
Total stockholders' equity (deficit) | (84,398) | $ (75,926) | (70,639) | $ (60,036) | $ (55,919) | $ (51,778) |
Pro Forma | ||||||
Subsequent Event [Line Items] | ||||||
Cash and cash equivalents | 270,827 | |||||
Common stock | 37 | |||||
Additional paid-in capital | 351,244 | |||||
Total stockholders' equity (deficit) | 261,714 | |||||
Convertible Preferred Stock | ||||||
Subsequent Event [Line Items] | ||||||
Convertible preferred stock | $ 175,043 | $ 175,043 | $ 70,363 | $ 70,363 | $ 60,933 | $ 60,933 |