(F) the failure, in and of itself, of POINT to meet any internal or external projections, forecasts, estimates or predictions in respect of any financial or operating metrics before, on or after October 2, 2023, or changes in the market price or trading volume of POINT common stock or the credit rating of POINT (it being understood that the underlying facts giving rise or contributing to such failure or change may be taken into account in determining whether there has been a Company Material Adverse Effect if such facts are not otherwise excluded under this definition);
(G) the announcement, pendency or performance of any of the Transactions, including the identity of, or any facts or circumstances relating to, Lilly, Purchaser or their respective affiliates, any stockholder proceeding (direct or derivative) in respect of the Merger Agreement or any of the Transactions and any loss of or change in relationship, contractual or otherwise, with any Governmental Entity, supplier, vendor, service provider, collaboration partner, licensor, licensee or any other party having business dealings with POINT or any POINT Subsidiary (including the exercise, or prospective exercise, by any party of any rights that arise upon a change of control), or departure of any employees or officers, of POINT or any POINT Subsidiary;
(H) POINT’s compliance with the covenants contained in the Merger Agreement;
(I) any action taken by POINT or any POINT Subsidiary at Lilly’s written request or with Lilly’s written consent;
(J) any matter described in the Disclosure Letter, to the extent the effects of such matter were known or reasonably foreseeable by Lilly;
(K) any change, event, condition, development, circumstance, state of facts, effect or occurrence that occur in connection with POINT’s, any POINT Subsidiary’s, or their competitors’ or potential competitors’, preclinical or clinical studies or the results of, or data derived from, such studies or announcements thereof or in connection therewith, or approval by the U.S. Food and Drug Administration (the “FDA”) or any other Governmental Entity (or other preclinical or clinical or regulatory developments), market entry or threatened market entry of any products competitive with any of POINT’s or any POINT Subsidiary’s products or product candidates (including POINT’s study (NCT04647526) evaluating metastatic castration-resistant prostate cancer using 177Lu-PNT2002 PSMA therapy after second-line hormonal treatment); or
(L) any recommendations, statements, decisions or other pronouncements made, published or proposed by professional medical organizations or payors, or any Governmental Entity or representative thereof, or any panel or advisory body empowered or appointed by any of the foregoing, relating to any products or product candidates of POINT or any POINT Subsidiary, or any competitors or potential competitors of POINT or any POINT Subsidiary, or the pricing, reimbursement or insurance coverage thereof,
except (x) in the case of clauses (A), (B), (C), (D) or (E), to the extent that POINT and the POINT Subsidiaries, taken as a whole, are disproportionately affected thereby as compared with other participants in the industries in which POINT and the POINT Subsidiaries operate (in which case the incremental disproportionate impact or impacts may be taken into account in determining whether there has been a Company Material Adverse Effect) and (y) in the case of clauses (K) or (L), to the extent such change, event, condition, development, circumstance, state of facts, effect or occurrence results from (1) fraud by POINT or any POINT Subsidiary or (2) the FDA issuing one or more orders that impose a clinical hold on the investigation of all of POINT’s compounds in the PNT-2001, PNT-2002, PNT-2003, and PNT-2004 programs, including 177- Lu-PNT2002, Ac-255-PSMA-62, 177Lu-DOTATATE, and 177-LuPNT6555 and 255Ac-PNT6555, respectively, the result of which would reasonably be likely to result in a termination of, or a delay of 12 months or more in dosing patients in such investigation (in which case such change, event, condition, development, circumstance, state of facts, effect or occurrence, to the extent resulting from such fraud or order, may be taken into account in determining whether there has been a Company Material Adverse Effect).
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