COMPASS Pathways (CMPS) F-3ASR Automatic shelf registration (foreign)

Exhibit 23.1

CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

We hereby consent to the incorporation by reference in this Registration Statement on Form F-3 of COMPASS Pathways plc of our report dated March 9, 2021relating to the financial statements, which appears in COMPASS Pathways plc's Annual Report on Form 20-F- for the year ended December 31, 2020. We also consent to the reference to us under the heading “Experts” in such Registration Statement.

/s/ PricewaterhouseCoopers LLP

Reading, United Kingdom

October 8, 2021